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页码: 132/1028 每页显示数量

Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation

Authors: Leena Halim, Kushal K Das, Daniel Larcombe-Young, Adam Ajina, Andrea Candelli, Reuben Benjamin, Richard Dillon, David M Davies, John Maher

Journal: Front Immunol

PubMed ID: 35222427

Doi: 10.3389/fimmu.2022.836549

Products & Services: Mutagenesis Services

The suppressor of copper sensitivity protein C from Caulobacter crescentus is a trimeric disulfide isomerase that binds copper(I) with subpicomolar affinity

Authors: Guillaume A Petit, Yaoqin Hong, Karrera Y Djoko, Andrew E Whitten, Emily J Furlong, Airlie J McCoy, Jacqueline M Gulbis, Makrina Totsika, Jennifer L Martin, Maria A Halili

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35234148

Doi: 10.1107/S2059798322000729

Products & Services: Bacterial Expression

Bioinformatic characterization of a triacylglycerol lipase produced by isolated from the decaying seed of

Authors: Benjamin O Ezema, Kingsley O Omeje, Roslyn M Bill, Alan D Goddard, Sabinus Oscar O Eze, Alfred Fernandez-Castane

Journal: J Biomol Struct Dyn

PubMed ID: 35147487

Doi: 10.1080/07391102.2022.2035821

Products & Services: Codon Optimization

Identification and mapping of post-transcriptional modifications on the HIV-1 antisense transcript Ast in human cells

Authors: Mariana Estevez, Rui Li, Biplab Paul, Kaveh Daneshvar, Alan C Mullen, Fabio Romerio, Balasubrahmanyam Addepalli

Journal: RNA

PubMed ID: 35168996

Doi: 10.1261/rna.079043.121

Products & Services: Gene Synthesis

IL-4 plays an essential role in DnaJ-ΔA146Ply-mediated immunoprotection against Streptococcus pneumoniae in mice

Authors: Yi Hu, Lian Li, Wenchun Xu, Kaifeng Wu, Jiangming Xiao, Yang Peng, Yusi Liu, Yibing Yin, Xuemei Zhang

Journal: Mol Immunol

PubMed ID: 35114487

Doi: 10.1016/j.molimm.2022.01.010

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Islet Regeneration and Pancreatic Duct Glands in Human and Experimental Diabetes

Authors: Diletta Overi, Guido Carpino, Marta Moretti, Antonio Franchitto, Lorenzo Nevi, Paolo Onori, Enrico De Smaele, Luca Federici, Daniele Santorelli, Marella Maroder, Lola M Reid, Vincenzo Cardinale, Domenico Alvaro, Eugenio Gaudio

Journal: Front Cell Dev Biol

PubMed ID: 35186929

Doi: 10.3389/fcell.2022.814165

Products & Services: Bacterial Expression

IL-9/STAT3/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity

Authors: Liuling Xiao, Xingzhe Ma, Lingqun Ye, Pan Su, Wei Xiong, Enguang Bi, Qiang Wang, Miao Xian, Maojie Yang, Jianfei Qian, Qing Yi

Journal: J Clin Invest

PubMed ID: 35192544

Doi: 10.1172/JCI153247

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Enhanced transglycosylation activity of an Endo-F3 mutant by ligand-directed localization

Authors: Xiangman Zou, Zhi Liu, Liya Liu, Wei Shi, Wanzhen Li, Zifen Guo, Feng Tang, Wei Huang

Journal: Org Biomol Chem

PubMed ID: 35166761

Doi: 10.1039/d2ob00030j

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RNA interference targeting UL25 gene as a gene therapy approach against BHV-1

Authors: Elaheh Amjadimanesh, Azam Mokhtari, Behnaz Saffar

Journal: Res Vet Sci

PubMed ID: 35182967

Doi: 10.1016/j.rvsc.2022.02.007

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SARS-CoV-2 Variants Increase Kinetic Stability of Open Spike Conformations as an Evolutionary Strategy

Authors: Ziwei Yang, Yang Han, Shilei Ding, Wei Shi, Tongqing Zhou, Andrés Finzi, Peter D Kwong, Walther Mothes, Maolin Lu

Journal: MBio

PubMed ID: 35164561

Doi: 10.1128/mbio.03227-21

Products & Services: Gene Synthesis

Germinal centre-driven maturation of B cell response to mRNA vaccination

Authors: Wooseob Kim, Julian Q Zhou, Stephen C Horvath, Aaron J Schmitz, Alexandria J Sturtz, Tingting Lei, Zhuoming Liu, Elizaveta Kalaidina, Mahima Thapa, Wafaa B Alsoussi, Alem Haile, Michael K Klebert, Teresa Suessen, Luis Parra-Rodriguez, Philip A Mudd, Sean P J Whelan, William D Middleton, Sharlene A Teefey, Iskra Pusic, Jane A O'Halloran, Rachel M Presti, Jackson S Turner, Ali H Ellebedy

Journal: Nature

PubMed ID: 35168246

Doi: 10.1038/s41586-022-04527-1

Products & Services: Plasmid DNA Preparation

Disentangling the recognition complexity of a protein hub using a nanopore

Authors: Lauren Ashley Mayse, Ali Imran, Motahareh Ghahari Larimi, Michael S Cosgrove, Aaron James Wolfe, Liviu Movileanu

Journal: Nat Commun

PubMed ID: 35190547

Doi: 10.1038/s41467-022-28465-8

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Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy

Authors: Sheng-Han Kuo, Inmaculada Tasset, Melody M Cheng, Antonio Diaz, Ming-Kai Pan, Ori J Lieberman, Samantha J Hutten, Roy N Alcalay, Sangjun Kim, Pilar Ximénez-Embún, Li Fan, Donghoon Kim, Han Seok Ko, Talene Yacoubian, Ellen Kanter, Ling Liu, Guomei Tang, Javier Muñoz, Sergio Pablo Sardi, Aiqun Li, Li Gan, Ana Maria Cuervo, David Sulzer

Journal: Sci Adv

PubMed ID: 35138901

Doi: 10.1126/sciadv.abm6393

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Humoral Immunity to Allogeneic Immunoproteasome-Expressing Mesenchymal Stromal Cells Requires Efferocytosis by Endogenous Phagocytes

Authors: Jean-Pierre Bikorimana, Jamilah Abusarah, Natasha Salame, Nehme El-Hachem, Riam Shammaa, Moutih Rafei

Journal: Cells

PubMed ID: 35203247

Doi: 10.3390/cells11040596

Products & Services: Peptide Synthesis

CNOT6: A Novel Regulator of DNA Mismatch Repair

Authors: Peng Song, Shaojun Liu, Dekang Liu, Guido Keijzers, Daniela Bakula, Shunlei Duan, Niels de Wind, Zilu Ye, Sergey Y Vakhrushev, Morten Scheibye-Knudsen, Lene Juel Rasmussen

Journal: Cells

PubMed ID: 35159331

Doi: 10.3390/cells11030521

Products & Services: Plasmid DNA Preparation

mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients

Authors: Elena Azzolini, Chiara Pozzi, Luca Germagnoli, Bianca Oresta, Nicola Carriglio, Mariella Calleri, Carlo Selmi, Maria De Santis, Silvia Finazzi, Carmelo Carlo-Stella, Alexia Bertuzzi, Francesca Motta, Angela Ceribelli, Alberto Mantovani, Fabrizio Bonelli, Maria Rescigno

Journal: Life Sci Alliance

PubMed ID: 35169017

Doi: 10.26508/lsa.202201381

Alteration of the translational readthrough isoform AQP4ex induces redistribution and downregulation of AQP4 in human glioblastoma

Authors: Onofrio Valente, Raffaella Messina, Giuseppe Ingravallo, Emilio Bellitti, Domenico Sergio Zimatore, Luigi de Gennaro, Pasqua Abbrescia, Roberta Pati, Claudia Palazzo, Grazia Paola Nicchia, Maria Trojano, Francesco Signorelli, Antonio Frigeri

Journal: Cell Mol Life Sci

PubMed ID: 35187599

Doi: 10.1007/s00018-021-04123-y

Products & Services: Gene Synthesis

Overexpression of m6A-factors METTL3, ALKBH5, and YTHDC1 alters HPV16 mRNA splicing

Authors: Xiaoxu Cui, Kersti Nilsson, Naoko Kajitani, Stefan Schwartz

Journal: Virus Genes

PubMed ID: 35190939

Doi: 10.1007/s11262-022-01889-6

Products & Services: Gene Synthesis

Enzyme immunoassays (EIA) for serodiagnosis of human leptospirosis: specific IgG3/IgG1 isotyping may further inform diagnosis of acute disease

Authors: Elsa Fortes-Gabriel, Mariana Soares Guedes, Advait Shetty, Charles Klazer Gomes, Teresa Carreira, Maria Luísa Vieira, Lisa Esteves, Luísa Mota-Vieira, Maria Gomes-Solecki

Journal: PLoS Negl Trop Dis

PubMed ID: 35196321

Doi: 10.1371/journal.pntd.0010241

Products & Services: Gene Synthesis

Collection of Monoclonal Antibodies Targeting SARS-CoV-2 Proteins

Authors: Marina Pribanić Matešić, Paola Kučan Brlić, Tihana Lenac Roviš, Željka Mačak Šafranko, Abigael Eva Chaouat, Karmela Miklić, Suzana Malić, Nina Ivanković, Maren Schubert, Federico Bertoglio, Alemka Markotić, Ofer Mandelboim, Stipan Jonjić, Ilija Brizić

Journal: Viruses

PubMed ID: 35216036

Doi: 10.3390/v14020443

Products & Services: Bacterial Expression

Zinc finger protein 277 is an intestinal transit-amplifying cell marker and colon cancer oncogene

Authors: Guofeng Xie, Zhongsheng Peng, Jinqing Liang, Shannon M Larabee, Cinthia B Drachenberg, Harris Yfantis, Jean-Pierre Raufman

Journal: JCI Insight

PubMed ID: 35015732

Doi: 10.1172/jci.insight.150894

Products & Services: Catalog Antibody

The cell adhesion protein dystroglycan affects the structural remodeling of dendritic spines

Authors: Izabela Figiel, Ewa Bączyńska, Tomasz Wójtowicz, Marta Magnowska, Anna Buszka, Monika Bijata, Jakub Włodarczyk

Journal: Sci Rep

PubMed ID: 35169214

Doi: 10.1038/s41598-022-06462-7

Products & Services: PCR Cloning and Subcloning

ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation

Authors: Xiuyuan Zhang, Qijian Zheng, Xiuying Yue, Zhanna Yuan, Jiming Ling, Yanzhi Yuan, Yanying Liang, Aihua Sun, Yuchen Liu, Hui Li, Kaikun Xu, Fuchu He, Jian Wang, Jin Wu, Chunling Zhao, Chunyan Tian

Journal: J Exp Clin Cancer Res

PubMed ID: 35227287

Doi: 10.1186/s13046-022-02288-3

Products & Services: Mammalian Expression

Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange Factor, Disrupts Corticogenesis in Neurodevelopmental Phenotypes

Authors: Masashi Nishikawa, Hidenori Ito, Hidenori Tabata, Hiroshi Ueda, Koh-Ichi Nagata

Journal: Cells

PubMed ID: 35203342

Doi: 10.3390/cells11040696

Products & Services: Custom Vector Construction

Characterization of adenine phosphoribosyltransferase (APRT) activity in Trypanosoma brucei brucei: Only one of the two isoforms is kinetically active

Authors: Kayla Glockzin, Thomas D Meek, Ardala Katzfuss

Journal: PLoS Negl Trop Dis

PubMed ID: 35104286

Doi: 10.1371/journal.pntd.0009926

Products & Services: Custom Vector Construction

Immunogenicity and safety of an intradermal fractional third dose of ChAdOx1 nCoV-19/AZD1222 vaccine compared with those of a standard intramuscular third dose in volunteers who previously received two doses of CoronaVac: A randomized controlled trial

Authors: Kriangkrai Tawinprai, Taweegrit Siripongboonsitti, Thachanun Porntharukchareon, Kasiruck Wittayasak, Nawarat Thonwirak, Kamonwan Soonklang, Gaidganok Sornsamdang, Chirayu Auewarakul, Nithi Mahanonda

Journal: Vaccine

PubMed ID: 35210118

Doi: 10.1016/j.vaccine.2022.02.019

Leveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors

Authors: Xiyao Cheng, Rong Chen, Ting Zhou, Bailing Zhang, Zichun Li, Meng Gao, Yongqi Huang, Huili Liu, Zhengding Su

Journal: Nat Commun

PubMed ID: 35228542

Doi: 10.1038/s41467-022-28721-x

Products & Services: Plasmid DNA Preparation

Reduced α-galactosidase A activity in zebrafish ( mirrors distinct features of Fabry nephropathy phenotype

Authors: Hassan O A Elsaid, Jessica Furriol, Maria Blomqvist, Mette Diswall, Sabine Leh, Naouel Gharbi, Jan Haug Anonsen, Janka Babickova, Camilla Tøndel, Einar Svarstad, Hans-Peter Marti, Maximilian Krause

Journal: Mol Genet Metab Rep

PubMed ID: 35242583

Doi: 10.1016/j.ymgmr.2022.100851

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Characterization of a Group of UDP-Glycosyltransferases Involved in the Biosynthesis of Triterpenoid Saponins of

Authors: Yanting Li, Jianxiu Li, Mengxue Diao, Longyun Peng, Shihai Huang, Nengzhong Xie

Journal: ACS Synth Biol

PubMed ID: 35107265

Doi: 10.1021/acssynbio.1c00469

Products & Services: Gene Synthesis

miR-AB, a miRNA-based shRNA viral toolkit for multicolor-barcoded multiplex RNAi at a single-cell level

Authors: Dapeng Wang, Jianbo Xiu, Jiangyue Zhao, Junli Luo

Journal: EMBO Rep

PubMed ID: 35201651

Doi: 10.15252/embr.202153691

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Changes in Non-Deamidated versus Deamidated Epitope Targeting and Disease Prediction during the Antibody Response to Gliadin and Transglutaminase of Infants at Risk for Celiac Disease

Authors: Ádám Diós, Bharani Srinivasan, Judit Gyimesi, Katharina Werkstetter, Rudolf Valenta, Sibylle Koletzko, Ilma R Korponay-Szabó

Journal: Int J Mol Sci

PubMed ID: 35269639

Doi: 10.3390/ijms23052498

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Poly(ADP-ribose) drives condensation of FUS via a transient interaction

Authors: Kevin Rhine, Morgan Dasovich, Joseph Yoniles, Mohsen Badiee, Sophie Skanchy, Laura R Ganser, Yingda Ge, Charlotte M Fare, James Shorter, Anthony K L Leung, Sua Myong

Journal: Mol Cell

PubMed ID: 35182479

Doi: 10.1016/j.molcel.2022.01.018

Products & Services: Plasmid DNA Preparation

Affibody Modified G-quadruplex DNA Micelles Incorporating Polymeric 5-Fluorodeoxyuridine for Targeted Delivery of Curcumin to Enhance Synergetic Therapy of HER2 Positive Gastric Cancer

Authors: Chao Zhang, Shuangqing Fu, Fanghua Zhang, Mengnan Han, Xuming Wang, Jie Du, Honglei Zhang, Wei Li

Journal: Nanomaterials (Basel)

PubMed ID: 35215023

Doi: 10.3390/nano12040696

Products & Services: Custom DNA/RNA Oligos

KIF18B promotes breast cancer cell proliferation, migration and invasion by targeting TRIP13 and activating the Wnt/β-catenin signaling pathway

Authors: Lan Liu, Zhaofeng Zhang, Xiulin Xia, Jing Lei

Journal: Oncol Lett

PubMed ID: 35251343

Doi: 10.3892/ol.2022.13232

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A CRISPR-based nucleic acid detection method for severe fever with thrombocytopenia syndrome virus

Authors: Yansong Zhang, Xuanyang Bai, Jinhui Li, Jing Xie, Huan Li, Lang Yang, Peihan Li, Peng Li, Hao Dong, Qichao Chen, Xinyan Hu, Yun Wang, Tingting Jiang, Hongbin Song, Leili Jia, Lizhong Li

Journal: Virus Res

PubMed ID: 35143909

Doi: 10.1016/j.virusres.2022.198691

Products & Services: Proteins, Expression, Isolation and Analysis

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

Authors: Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, François Ferron, Bruno Canard

Journal: Nat Commun

PubMed ID: 35110538

Doi: 10.1038/s41467-022-28113-1

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Lack of Induction of RBD-Specific Neutralizing Antibodies despite Repeated Heterologous SARS-CoV-2 Vaccination Leading to Seroconversion and Establishment of T Cell-Specific Memory in a Patient in Remission of Multiple Myeloma

Authors: Bernhard Kratzer, Doris Trapin, Pia Gattinger, Teresa Oberhofer, Al Nasar Ahmed Sehgal, Petra Waidhofer-Söllner, Arno Rottal, Ulrike Körmöczi, Katharina Grabmeier-Pfistershammer, Gerhard H Kopetzky, Franz Tischer, Rudolf Valenta, Winfried F Pickl

Journal: Vaccines (Basel)

PubMed ID: 35335006

Doi: 10.3390/vaccines10030374

Products & Services: Proteins, Expression, Isolation and Analysis

Myricetin reverses epithelial-endothelial transition and inhibits vasculogenic mimicry and angiogenesis of hepatocellular carcinoma by directly targeting PAR1

Authors: Ming Wang, Shanfa Ren, Zhun Bi, Liang Zhang, Mengqi Cui, Ronghao Sun, Jiali Bao, Dandi Gao, Bo Yang, Xiaoping Li, Mingjiang Li, Ting Xiao, Hong-Gang Zhou, Cheng Yang

Journal: Phytother Res

PubMed ID: 35229382

Doi: 10.1002/ptr.7427

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Extended β-Strands Contribute to Reversible Amyloid Formation

Authors: Kevin A Murray, Declan Evans, Michael P Hughes, Michael R Sawaya, Carolyn J Hu, Kendall N Houk, David Eisenberg

Journal: ACS Nano

PubMed ID: 35132852

Doi: 10.1021/acsnano.1c08043

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Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors

Authors: Nishanth Belugali Nataraj, Ashish Noronha, Joo Sang Lee, Soma Ghosh, Harsha Raj Mohan Raju, Arunachalam Sekar, Binyamin Zuckerman, Moshit Lindzen, Emilio Tarcitano, Swati Srivastava, Michael Selitrennik, Ido Livneh, Diana Drago-Garcia, Oscar Rueda, Carlos Caldas, Sima Lev, Tamar Geiger, Aaron Ciechanover, Igor Ulitsky, Rony Seger, Eytan Ruppin, Yosef Yarden

Journal: Cell Rep

PubMed ID: 35196484

Doi: 10.1016/j.celrep.2022.110418

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Blockage of NDUFB9‑SCD1 pathway inhibits adipogenesis

Authors: Shenglong Zhu, Jingwei Zhang, Wei Wang, Xuan Jiang, Yong Q Chen

Journal: J Physiol Biochem

PubMed ID: 35122619

Doi: 10.1007/s13105-022-00876-7

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Omicron adopts a different strategy from Delta and other variants to adapt to host

Authors: Xiaohong Du , Haijun Tang , Long Gao , Zhao Wu , Fang Meng , Ruhong Yan , Shigang Qiao, Jianzhong An , Chen Wang , F Xiao-Feng Qin

Journal: Signal Transduct Target Ther

PubMed ID: 35145066

Doi: 10.1038/s41392-022-00903-5

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Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila

Authors: Jung-Wan Mok , Kwang-Wook Choi

Journal: Cell Death Dis

PubMed ID: 35110540

Doi: 10.1038/s41419-022-04532-2

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Targeting IFN-λ Signaling Promotes Recovery from Central Nervous System Autoimmunity

Authors: Sindhu Manivasagam, Jessica L Williams, Lauren L Vollmer, Bryan Bollman, Juliet M Bartleson, Shenjian Ai, Gregory F Wu, Robyn S Klein

Journal: J Immunol

PubMed ID: 35181638

Doi: 10.4049/jimmunol.2101041

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Dynamic Interplay between Cockayne Syndrome Protein B and Poly(ADP-Ribose) Polymerase 1 during Oxidative DNA Damage Repair

Authors: Robert J Lake, Rabeya Bilkis, Hua-Ying Fan

Journal: Biomedicines

PubMed ID: 35203571

Doi: 10.3390/biomedicines10020361

Products & Services: Proteins, Expression, Isolation and Analysis

Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platform

Authors: Christopher Chevillard, Axelle Amen, Solène Besson, Dalil Hannani, Isabelle Bally, Valentin Dettling, Evelyne Gout, Christophe J Moreau, Marlyse Buisson, Salomé Gallet, Daphna Fenel, Emilie Vassal-Stermann, Guy Schoehn, Pascal Poignard, Marie-Claire Dagher, Pascal Fender

Journal: Mol Ther

PubMed ID: 35151843

Doi: 10.1016/j.ymthe.2022.02.011

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FRAGILE CULM 18 encodes a UDP-glucuronic acid decarboxylase required for xylan biosynthesis and plant growth in rice

Authors: Nan Ruan, Zhengjun Dang, Meihan Wang, Liyu Cao, Ye Wang, Sitong Liu, Yijun Tang, Yuwei Huang, Qun Zhang, Quan Xu, Wenfu Chen, Fengcheng Li

Journal: J Exp Bot

PubMed ID: 35104839

Doi: 10.1093/jxb/erac036

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Proteasome 26S subunit, non-ATPase 1 (PSMD1) facilitated the progression of lung adenocarcinoma by the de-ubiquitination and stability of PTEN-induced kinase 1 (PINK1)

Authors: Lihua Liu, Aihua Liu, Jun Dong, Zhongfu Zuo, Xuezheng Liu

Journal: Exp Cell Res

PubMed ID: 35192838

Doi: 10.1016/j.yexcr.2022.113075

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Differential escape of neutralizing antibodies by SARS-CoV-2 Omicron and pre-emergent sarbecoviruses

Authors: Lin-Fa Wang, Chee Wah Tan, Wan Ni Chia, Feng Zhu, Barnaby Young, Napaporn Chantasrisawad, Shi-Hsia Hwa, Aileen Ying-Yan Yeoh, Beng Lee Lim, Wee Chee Yap, Surinder Kaur Pada, Seow Yen Tan, Watsamon Jantarabenjakul, Shiwei Chen, Jinyan Zhang, Yun Yan Mah, Vivian Chen, Mark Chen, Supaporn Wacharapluesadee, Commit-Kzn Team, Opass Putcharoen, David Lye

Journal: Res Sq

PubMed ID: 35233568

Doi: 10.21203/rs.3.rs-1362541/v1

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Identification and Expression Analysis of WRKY Gene Family in Response to Abiotic Stress in

Authors: Tingting Zhang, Ying Xu, Yadan Ding, Wengang Yu, Jian Wang, Hanggui Lai, Yang Zhou

Journal: Front Genet

PubMed ID: 35186030

Doi: 10.3389/fgene.2022.800019

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