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Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex

Authors: Markella Konstantinidou, Marios Zingiridis, Marloes A M Pennings, Michael Fragkiadakis, Johanna M Virta, Jezrael L Revalde, Emira J Visser, Christian Ottmann, Luc Brunsveld, Constantinos G Neochoritis, Michelle R Arkin

Journal: Nature Communications

PubMed ID: 40659654

Doi: 10.1038/s41467-025-61176-4

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Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC)

Authors: Raghuvir Viswanatha, Samuel Entwisle, Yanhui Hu, Ah-Ram Kim, Kelly Reap, Matthew Butnaru, Mujeeb Qadiri, Stephanie E Mohr, Norbert Perrimon

Journal: Nature Communications

PubMed ID: 40659672

Doi: 10.1038/s41467-025-61692-3

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Systematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology

Authors: De Xing, Tao Bai, Ozlem Neyisci, Seyedeh Zahra Paylakhi, Alexander J Duval, Yasemin Tekin, Mazhar Adli

Journal: Nature Communications

PubMed ID: 40681502

Doi: 10.1038/s41467-025-61848-1

Products & Services: Gene Synthesis

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Authors: Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S Yarla, Lu Wang, Jindan Yu, Jonathan C Zhao, Ivet Bahar, Yong Wan

Journal: Advanced Science

PubMed ID: 40671262

Doi: 10.1002/advs.202415585

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Non-antibiotics disrupt colonization resistance against enteropathogens

Authors: Anne Grießhammer, Jacobo de la Cuesta-Zuluaga, Patrick Müller, Cordula Gekeler, Jan Homolak, Hsuan Chang, Katharina Schmitt, Chiara Planker, Verena Schmidtchen, Suchira Gallage, Erwin Bohn, Taylor H Nguyen, Jenny Hetzer, Mathias Heikenwälder, Kerwyn Casey Huang, Taiyeb Zahir, Lisa Maier

Journal: Nature

PubMed ID: 40670795

Doi: 10.1038/s41586-025-09217-2

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Natural variation of an E3 ubiquitin ligase encoding gene Chalk9 regulates grain chalkiness in rice

Authors: Zhi Hu, Hongchun Liu, Min Guo, Xiang Han, Youguang Li, Rujia Chen, Yifan Guo, Yihao Yang, Shengyuan Sun, Yong Zhou, Minghong Gu, Changjie Yan

Journal: Nature Communications

PubMed ID: 40683885

Doi: 10.1038/s41467-025-61683-4

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CRISPRi screen identifies FprB as a synergistic target for gallium therapy in Pseudomonas aeruginosa

Authors: Yu Zhang, Tingting Zhang, Xue Xiao, Yejun Wang, Adam Kawalek, Jinzhao Ou, Anmin Ren, Wenhao Sun, Vincent de Bakker, Yujie Liu, Yuelong Li, Liang Yang, Liang Ye, Ning Jia, Jan-Willem Veening, Xue Liu

Journal: Nature Communications

PubMed ID: 40595632

Doi: 10.1038/s41467-025-61208-z

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DRAM1 promotes the stability of lysosomal VAMP8 to enhance autolysosome formation and facilitates the extravasation

Authors: Rui Zhang, Xin Zhang, Hua Bai, Qiuyu Cheng, Xia Yao, Shi Li, Vincenzo Torraca, Chaojun Yan, Xueying Dong, Siyi Miao, Xueyuan Hu, Yeping Yu, Yueyan Wu, Hongfei Tan, Xin Chen, Shicheng Liu, Hao Lyu, Shuai Xiao, Dong Guo, Qi Zhang, Xing-Zhen Chen, Zhiyin Song, Cefan Zhou, Jingfeng Tang

Journal: Nature Communications

PubMed ID: 40595569

Doi: 10.1038/s41467-025-60887-y

Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation

Authors: Xiaoman Ju, Eva Maria Putz, Yaqi Liu, Dongchen Yuan, Guowei Sun, Stephane Koda, Zhuo Fu, Simin Shao, Chunrong Tong, Biping Deng, Jing Hu, Juming Yan

Journal: Nature Communications

PubMed ID: 40593670

Doi: 10.1038/s41467-025-60922-y.

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Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial

Authors: Mangalakumari Jeyanathan, Sam Afkhami, Michael R D'Agostino, Imran Satia, Dominik K Fritz, Kate Miyasaki, Jann C Ang, Anna Zganiacz, Karen J Howie, Marilyn Swinton, Emilio Aguirre, Michael B Zheng, Natallia Kazhdan, Anna Dvorkin-Gheva, Lawrence Mbuagbaw, Maria Fe C Medina, Nermin Diab, Danica L Brister, Gail M Gauvreau, Brian D Lichty, Matthew S Miller, Fiona Smaill, Zhou Xing

Journal: Nature Communications

PubMed ID: 40603330

Doi: 10.1038/s41467-025-60726-0

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PPP2R1A mutations portend improved survival after cancer immunotherapy

Authors: Yibo Dai, Anne Knisely, Mitsutake Yano, Minghao Dang, Emily M Hinchcliff, Sanghoon Lee, Annalyn Welp, Manoj Chelvanambi, Matthew Lastrapes, Heng Liu, Zhe Yuan, Chen Wang, Hao Nie, Stephanie Jean, Luis J Montaner, Jiakai Hou, Ami Patel, Shrina Patel, Bryan Fellman, Ying Yuan, Baohua Sun, Renganayaki Krishna Pandurengan, Edwin Roger Parra Cuentas, Joseph Celestino, Yan Liu, Jinsong Liu, R Tyler Hillman, Shannon N Westin, Anil K Sood, Pamela T Soliman, Aaron Shafer, Larissa A Meyer, David M Gershenson, David Vining, Dhakshinamoorthy Ganeshan, Karen Lu, Jennifer A Wargo, Weiyi Peng, Rugang Zhang, Linghua Wang, Amir A Jazaeri

Journal: Nature

PubMed ID: 40604275

Doi: 10.1038/s41586-025-09203-8

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Analysis of the Rehmannia chingii geneome identifies RcCYP72H7 as an epoxidase in iridoid glycoside biosynthesis

Authors: Fengqing Wang, Zhennan Jiang, Junge Gao, Chunyan Miao, Ci Song, Yahe Yang, Ning Ding, Yajing Li, Hongzheng Sun, Caixia Xie, Bao Zhang, Pengyu Zhang, Li Gu, Qiuwen Hao, Zhongyi Zhang, Luqi Huang, Yuan Yuan

Journal: Nature Communications

PubMed ID: 40593652

Doi: 10.1038/s41467-025-60909-9

Products & Services: Protein Electrophoresis and Western

Human neutrophil α-defensin HNP1 interacts with bacterial OmpA to promote Acinetobacter baumannii biofilm formation

Authors: Chongbing Liao, Qihui Liu, Gan Luo, Yinyue Luo, Dan Yao, Qingxia Wang, Jue Zhang, Yang Wu, Jialin Jin, Dan Xu, Wuyuan Lu

Journal: Nature Communications

PubMed ID: 40595622

Doi: 10.1038/s41467-025-60935-7

Products & Services: Protein Electrophoresis and Western

HIV-1 vif mediates ubiquitination of the proximal protomer in the APOBEC3H dimer to induce degradation

Authors: Katarzyna A Skorupka, Kazuhiro Matsuoka, Bakar Hassan, Rodolfo Ghirlando, Vanivilasini Balachandran, Ting-Hua Chen, Kylie J Walters, Celia A Schiffer, Matthias Wolf, Yasumasa Iwatani, Hiroshi Matsuo

Journal: Nature Communications

PubMed ID: 40593686

Doi: 10.1038/s41467-025-60984-y

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The haplotype-resolved telomere-to-telomere genome and OMICS analyses reveal genetic responses to tapping in rubber tree

Authors: Chaochao Li, Yuan Yuan, Zhiyi Nie, Tingkai Wu, Zhiyuan Wang, Jiangxia Qiao, Zhi Deng, Xiaobo Wang, Dong Xu, Xu Wang, Shuo Cao, Bingqin Li, Zewei An, Wenguan Wu, Zhongxin Jin, Huasun Huang, Wei Hu, Yongfeng Zhou, Han Cheng

Journal: Nature Communications

PubMed ID: 40624070

Doi: 10.1038/s41467-025-61527-1

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Structural basis for engagement of Western Equine Encephalitis Virus with the PCDH10 receptor

Authors: Shengjian Liang, Yan Yang, Yixiao Liu, Zhili Xu, Jichao Hou, Donghan Li, Lixin Zhao, Chuyu Hu, Xiaoke Liu, Zihe Rao, Yanyi Wang, Zhiyong Lou

Journal: Nature Communications

PubMed ID: 40628733

Doi: 10.1038/s41467-025-61659-4

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The defensome of prokaryotes in aquifers

Authors: Pengwei Li, Zongzhi Wu, Tang Liu, Chunfang Deng, Quan Liu, Jinren Ni

Journal: Nature Communications

PubMed ID: 40659683

Doi: 10.1038/s41467-025-61467-w

Products & Services: PCR Cloning and Subcloning

Staphylococcus aureus LukMF' targets neutrophils to promote skin and soft tissue infection

Authors: Daiane Boff, Ravishankar Chandrasekaran, Gregory Putzel, Rachel M Kratofil, Xuhui Zheng, Ashley Castellaw, Kody Mansfield, Ikjot Sidhu, Avantika Dhabaria, Keenan A Lacey, Sandra Gonzalez, Filadelfia Tadjibaeva, Beatrix Ueberheide, Cynthia Loomis, Alejandro Pironti, Silva Holtfreter, Shruti Naik, Victor J Torres

Journal: SCIENCE ADVANCES

PubMed ID: 40614206

Doi: 10.1126/sciadv.adr5240

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Optimizing a human monoclonal antibody for better neutralization of SARS-CoV-2

Authors: Qian Wang, Yicheng Guo, Ryan G Casner, Jian Yu, Manoj S Nair, Jerren Ho, Eswar R Reddem, Ian A Mellis, Madeline Wu, Chih-Chen Tzang, Hsiang Hong, Yaoxing Huang, Lawrence Shapiro, Lihong Liu, David D Ho

Journal: Nature Communications

PubMed ID: 40615407

Doi: 10.1038/s41467-025-61472-z

Products & Services: Gene Synthesis

Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in bacteria

Authors: Belen Sotomayor, Thomas C Donahue, Sai Pooja Mahajan, May N Taw, Sophia W Hulbert, Erik J Bidstrup, D Natasha Owitipana, Alexandra Pang, Xu Yang, Souvik Ghosal, Christopher A Alabi, Parastoo Azadi, Jeffrey J Gray, Michael C Jewett, Lai-Xi Wang, Matthew P DeLisa

Journal: Nature Communications

PubMed ID: 40610439

Doi: 10.1038/s41467-025-61440-7

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Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses

Authors: Tobias Plowman, Tom Hofland, Callum Hall, Rachael Thompson, Judith Pape, Kevin W Ng, Laura Doglio, George Kassiotis

Journal: SCIENCE ADVANCES

PubMed ID: 40614216

Doi: 10.1126/sciimmunol.adr1105

Products & Services: Gene Synthesis

The mitotic chromosome periphery modulates chromosome mechanics

Authors: Tania Mendonca, Roman Urban, Kellie Lucken, George Coney, Neil M Kad, Manlio Tassieri, Amanda J Wright, Daniel G Booth

Journal: Nature Communications

PubMed ID: 40640170

Doi: 10.1038/s41467-025-61755-5

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Structure-guided engineering of snake toxins for selective modulation of adrenergic and muscarinic receptors

Authors: Yixuan Zhong, Huihui Tao, Yu Zhang, Binbin He, Haizhan Jiao, Dandan Wang, Maikun Teng, Hongli Hu, Qiong Guo, Yuyong Tao

Journal: Nature Communications

PubMed ID: 40659608

Doi: 10.1038/s41467-025-61695-0

Phosphorylation-activated G protein signaling stabilizes TCP14 and JAZ3 to repress JA signaling and enhance plant immunity

Authors: Haiyan Jia, Natalie Hewitt, Lucía Jordá, Tigran M Abramyan, Josh Tolliver, Janice L Jones, Kinya Nomura, Jing Yang, Sheng-Yang He, Alexander Tropsha, Antonio Molina, Henrik G Dohlman, Alan M Jones

Journal: Molecular plant

PubMed ID: 40509595

Doi: 10.1016/j.molp.2025.06.004

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Rice E3 ubiquitin ligase BLAST AND BTH-INDUCED 1 targets jasmonic acid signaling co-repressors to release Myelocytomatosis protein 2 for modulating immune responses against blast fungus

Authors: Yan Bi , Yuqing Yan , Hui Wang , Leeza Tariq , Dayong Li , Fengming Song

Journal: International Journal of Biological Macromolecules

PubMed ID: 40543771

Doi: doi.org/10.1016/j.ijbiomac.2025.145363

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LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Authors: Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng

Journal: Advanced Science

Doi: doi.org/10.1002/advs.202416809

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Activation of mechanosensitive ion channel Piezo1 linking metabolic reprogramming and pro-inflammatory responses in hepatocellular carcinoma

Authors: Juanfen Mo, YuXuan Zhang, Chenxi Cao, WeiLi Zheng, Li Zheng, Xiaoguang Wang, Shiyue Wang, Jiayuan Wu, Yi Bao

Journal: Cell Communication and Signaling

PubMed ID: 40514668

Doi: 10.1186/s12964-025-02289-7

Products & Services: Protein and Antibody Isolation

Topical delivery of a human single-domain antibody targeting IL-33 to inhibit mucosal inflammation

Authors: Keke Huang, Yuqing Wu, Yu Kong, Qingyuan Xu, Mingwei Lv, Yirou Zhang, Yiteng Lu, Quanxiao Li, Cheng Li, Wenping Song, Xiaoyi Zhu, Zhenlin Yang, Changchang Xin, Xujiao Zhou, Tianlei Ying, Yanling Wu, Jiaxu Hong

Journal: Cellular & molecular immunology

PubMed ID: 40500403

Doi: 10.1038/s41423-025-01305-7

Products & Services: Protein and Antibody Isolation

An all-silk-based functional system promotes tendon regeneration by regulating the cell fate of TSPCs in an inflammatory microenvironment

Authors: Qingyun Mo, Haotian Zheng, Chuanquan Liu, Yuzhi Sun, Zhicheng Cao, Renwang Sheng, Yanan Zhang, Mingyue Wang, Baian Kuang, Ludvig J Backman, Jiaxiang Li, Wei Zhang, Jialin Chen

Journal: Acta Biomaterialia

PubMed ID: 40409996

Doi: 10.1016/j.actbio.2025.05.040

Products & Services: Recombinant Proteins

AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition

Authors: Keyu Kong, Li Liu, Renfang Zhang, Yongyun Chang, Yueming Shao, Chen Zhao, Hua Qiao, Minghao Jin, Xuzhuo Chen, Wentao Shi, Xinru Wu, Wenxuan Fan, Yuehao Hu, Kewei Rong, Pu Zhang, Baixing Li, Jingwei Zhang, Peixiang Ma, Xiaoling Zhang, Huiwu Li, Zanjing Zhai

Journal: Bone Research

PubMed ID: 40461512

Doi: 10.1038/s41413-025-00431-2

Products & Services: Recombinant Proteins

Functionalized Annealed Microgels for Spatial Control of Osteogenic and Chondrogenic Differentiation

Authors: Jeremy M. Lowen, Erika E. Wheeler, Nathan K. Shimamoto, David H. Ramos-Rodriguez, Katherine H. Griffin, Gabriella C. Bond, J. Kent Leach

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202311017

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The scaffold protein RACK1 regulates root growth and gravitropic response by recruiting PINOID to phosphorylate the auxin efflux transporter PIN-FORMED2

Authors: Shujuan Zhang, Qi Liao, Jiale Li, Wenbao Liu, Xinwen Zhang, Xindi Tian, Shucai Wang, Qun Zhang

Journal: Journal of integrative plant biology

PubMed ID: 39912541

Doi: 10.1111/jipb.13858

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Circulating myeloid-derived suppressor cell load and disease severity are associated to an enhanced oligodendroglial production in a murine model of multiple sclerosis

Authors: Mari Paz Serrano-Regal, Celia Camacho-Toledano, Inmaculada Alonso-García, María Cristina Ortega, Isabel Machín-Díaz, Rafael Lebrón-Galán, Jénnifer García-Arocha, Leticia Calahorra, Manuel Nieto-Díaz, Diego Clemente

Journal: Neurobiology of disease

PubMed ID: 40250717

Doi: 10.1016/j.nbd.2025.106919

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Epitope-Optimized Influenza Hemagglutinin Nanoparticle Vaccine Provides Broad Cross- Reactive Immunity against H9N2 Influenza Virus

Authors: Mengchan Hao, Yanhai Wang, Wenxue Yang, Meng Xu, Yiwei Guan, Yuan Zhang, JianJun Chen

Journal: ACS Nano

PubMed ID: 40452158

Doi: 10.1021/acsnano.5c03199

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Polyketide synthase-derived sphingolipids mediate microbiota protection against a bacterial pathogen in C. elegans

Authors: Lena Peters, Moritz Drechsler, Michael A Herrera, Jing Liu, Barbara Pees, Johanna Jarstorff, Anna Czerwinski, Francesca Lubbock, Georgia Angelidou, Liesa Salzer, Karlis Arturs Moors, Nicole Paczia, Yi-Ming Shi, Hinrich Schulenburg, Christoph Kaleta, Michael Witting, Manuel Liebeke, Dominic J Campopiano, Helge B Bode, Katja Dierking

Journal: Nature Communications

PubMed ID: 40461452

Doi: 10.1038/s41467-025-60234-1

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Antigen persistence and TLR stimulation contribute to induction of a durable HIV-1-specific neutralizing antibody response

Authors: Kenta Matsuda, Mitra Harrison, Eleanor Wettstein, Jessica Pederson, Alyssa A Pullano, Lyuba Bolkhovitinov, Breanna Kim, Isabel Steinberg, Trevor Griesman, Sarah Stuccio, Daniel Rogan, Andy Patamawenu, Tulley Shofner, Nathaniel E Wright, Jonathan D Webber, Freya Van't Veer, Rachel Roenicke, Emma Koory, Peyton M Roeder, Ellison Ober, Benjamin Leach, Yaroslav Tsybovsky, Tyler Stephens, Ivan Del Moral-Sanchez, Ilja Bontjer, Lori W McGinnes-Cullen, Eric Chu, Jason Liang, Jonathan L Torres, Ryan N Lin, Andy S Tran, Gabrielle Dziubla, Leonid Serebryannyy, Sandeep Narpala, Bob Lin, Mike Castro, Gabriel Ozorowski, Andrew B Ward, Rogier W Sanders, Peter D Kwong, Javier Guenaga, Richard Wyatt, Trudy Morrison, Mark Connors

Journal: Nature Communications

PubMed ID: 40461490

Doi: 10.1038/s41467-025-60481-2

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Structural and molecular mechanisms of an Ro60 homolog from a Thermus bacteriophage

Authors: Zetao Hu, Zhaohui Jin, Lulu Guo, Ling Zeng, Xuanjia Dong, Lin Jiang, Wenting Dai, Jinbiao Ma, Ying Huang

Journal: Nucleic Acids Research

PubMed ID: 40464688

Doi: 10.1093/nar/gkaf470

A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent

Authors: Misha Klein, Arnab Das, Subhas C Bera, Thomas K Anderson, Dana Kocincova, Hery W Lee, Bing Wang, Flavia S Papini, John C Marecki, Jamie J Arnold, Craig E Cameron, Kevin D Raney, Irina Artsimovitch, Mathias Götte, Robert N Kirchdoerfer, Martin Depken, David Dulin

Journal: Nucleic Acids Research

PubMed ID: 40464687

Doi: 10.1093/nar/gkaf450

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CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma

Authors: Yin Wang, Fen Chang, Zinan Li, Chengcheng Duan, Xiangkai Sun, Siyu Wang, Dongmin Wei, Wenming Li, Ye Qian, Shengda Cao, Juan Zhao, Dapeng Lei

Journal: Advanced Science

PubMed ID: 40464594

Doi: 10.1002/advs.202414961

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H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells

Authors: S Arfè, T Karagyozova, A Forest, D Bingham, H Hmidan, D Mazaud, M Garnier, P Le Baccon, E Meshorer, J-P Quivy, G Almouzni

Journal: Nature Communications

PubMed ID: 40461574

Doi: 10.1038/s41467-025-60430-z

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Primer-Disk-Enabled DNA Data Storage System with Index and Record-Many-Read-Many Features

Authors: Jiaxiang Ma, Yu Yang, Ben Pei, Shengli Mi, Zhuo Xiong, Liliang Ouyang

Journal: Advanced Science

PubMed ID: 40464608

Doi: 10.1002/advs.202502367

O-GalNAc Glycosylation Activates MBL-Mediated Complement and Coagulation Cascades to Drive Organotropic Metastasis

Authors: Xinyu Chen, Wei Bao, Kaiyuan Liu, Na Jing, Genyu Du, Luyao Jiang, Qian You, Yingchao Zhang, Penghui Xu, Chaping Cheng, Nan Wang, Xialian Xi, Mingyue Wang, Yiyun Liu, Jinming Wang, Huifang Zhao, Shilei Zhang, Dinglan Wu, Chi-Fai Ng, Jiahua Pan, Wei Xue, Wei-Qiang Gao, Pengcheng Zhang, Kai Zhang, Helen He Zhu

Journal: Advanced Science

PubMed ID: 40492591

Doi: 10.1002/advs.202504809

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CPK28-mediated Ca2+ signaling regulates STOP1 localization and accumulation to facilitate plant aluminum resistance

Authors: Yingtang Ma, Hailiang Zheng, Ina Schmitz-Thom, Jiawen Wang, Fanglin Zhou, Chongyang Li, Yaling Zhang, Yiqiu Cheng, Daisuke Miki, Jörg Kudla, Chao-Feng Huang

Journal: Nature Communications

PubMed ID: 40473612

Doi: 10.1038/s41467-025-60427-8

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ZmSSRP1, transactivated by OPAQUE11, positively regulates starch biosynthesis in maize endosperm

Authors: Long Chen, Chengyun Wu, Quanzhi Li, Ming Du, Yan Li, Beijiu Cheng, Xiaoyu Li, Jiandong Wu

Journal: Plant Biotechnology Journal.

PubMed ID: 40517398

Doi: 10.1111/pbi.70191

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KIF2C condensation concentrates PLK1 and phosphorylated BRCA2 on kinetochore microtubules in mitosis

Authors: Anastasiia Skobelkina, Manon Julien, Sylvain Jeannin, Simona Miron, Tom Egger, Rady Chaaban, Guillaume Bouvignies, Emile Alghoul, Rania Ghouil, Claire Friel, Didier Busso, Juan C Cañas, François-Xavier Theillet, Romain Le Bars, Aura Carreira, Angelos Constantinou, Jihane Basbous, Sophie Zinn-Justin

Journal: Nucleic Acids Research

PubMed ID: 40498077

Doi: 10.1093/nar/gkaf476

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A four-in-one replicase integrating key enzymatic activities for DNA replication

Authors: Yuxin Zhang , Xueling Lu , Bin Zhu , Fengtao Huang

Journal: Nucleic Acids Research

PubMed ID: 40548937

Doi: 10.1093/nar/gkaf542

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TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family

Authors: Philip Schmiege, Dawid Jaślan, Michael Fine, Nidish Ponath Sadanandan, Alexandra Hatton, Nadia Elghobashi-Meinhardt, Christian Grimm, Xiaochun Li

Journal: Nature Communications

PubMed ID: 40527873

Doi: 10.1038/s41467-025-60710-8

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PAM-free hairpin target binding activates trans-cleavage activity of Cas12a

Authors: Xiaolong Li, Zixuan Zhu, Jiani Wu, Changjiang Li, Zhujun Liu, Jinjin Wang, Pu Li, Zhen Zhang, Yongming Huang, Jiaxin Hong, Tongbo Wu

Journal: Nucleic Acids Research

PubMed ID: 40557869

Doi: 10.1093/nar/gkaf596

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An Antagonism Between Ethylene Signaling and DNA Methylation Orchestrates the Progression of Leaf Senescence in Non-heading Chinese Cabbage

Authors: Dingyu Zhang, Yong Luo, Han Wang, Xiaofeng Li, Liming Miao, Lu Gao, Haibo Hao, Xinman Wang, Benke Kuai, Hongfang Zhu, Guodong Ren

Journal: Advanced Science

PubMed ID: 40549976

Doi: 10.1002/advs.202414954

An Il12 mRNA-LNP adjuvant enhances mRNA vaccine-induced CD8 T cell responses

Authors: Emily A Aunins, Anthony T Phan, Mohamad-Gabriel Alameh, Garima Dwivedi, Elisa Cruz-Morales, David A Christian, Ying Tam, Molly E Bunkofske, Anabel Zabala Peñafiel, Keenan M O'Dea, Maria Merolle, Colleen Furey, Phillip Scott, Robert H Vonderheide, Scott E Hensley, Ross M Kedl, Drew Weissman, Christopher A Hunter

Journal: Science immunology

PubMed ID: 40478935

Doi: 10.1126/sciimmunol.ads1328