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Structural characterization of the Myxococcus xanthus encapsulin and ferritin-like cargo system gives insight into its iron storage mechanism

Authors: Elif Eren, Bing Wang, Dennis C Winkler, Norman R Watts, Alasdair C Steven, Paul T Wingfield

Journal: Structure

PubMed ID: 35150605

Doi: 10.1016/j.str.2022.01.008

Products & Services: Bacterial Expression

Optical Sensors and Actuators for Probing Proximity-Dependent Biotinylation in Living Cells

Authors: Rui Chen, Ningxia Zhang, Yubin Zhou, Ji Jing

Journal: Front Cell Neurosci

PubMed ID: 35250484

Doi: 10.3389/fncel.2022.801644

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Robust and Functional Immune Memory Up to 9 Months After SARS-CoV-2 Infection: A Southeast Asian Longitudinal Cohort

Authors: Hoa Thi My Vo, Alvino Maestri, Heidi Auerswald, Sopheak Sorn, Sokchea Lay, Heng Seng, Sotheary Sann, Nisa Ya, Polidy Pean, Philippe Dussart, Olivier Schwartz, Sovann Ly, Timothée Bruel, Sowath Ly, Veasna Duong, Erik A Karlsson, Tineke Cantaert

Journal: Front Immunol

PubMed ID: 35185909

Doi: 10.3389/fimmu.2022.817905

Products & Services: Proteins, Expression, Isolation and Analysis

Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates

Authors: Remkes A Scheele, Laurens H Lindenburg, Maya Petek, Markus Schober, Kevin N Dalby, Florian Hollfelder

Journal: Nat Commun

PubMed ID: 35149678

Doi: 10.1038/s41467-022-28396-4

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Defining molecular glues with a dual-nanobody cannabidiol sensor

Authors: Shiyun Cao, Shoukai Kang, Haibin Mao, Jiayu Yao, Liangcai Gu, Ning Zheng

Journal: Nat Commun

PubMed ID: 35145136

Doi: 10.1038/s41467-022-28507-1

Products & Services: Mammalian Expression

Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions

Authors: Fin J Milder, Mandy Jongeneelen, Tina Ritschel, Pascale Bouchier, Ilona J M Bisschop, Martijn de Man, Daniel Veldman, Lam Le, Baerbel Kaufmann, Mark J G Bakkers, Jarek Juraszek, Boerries Brandenburg, Johannes P M Langedijk

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35131851

Doi: 10.1073/pnas.2115379119

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T cell receptors employ diverse strategies to target a p53 cancer neoantigen

Authors: Daichao Wu, Ragul Gowathaman, Brian G Pierce, Roy A Mariuzza

Journal: J Biol Chem

PubMed ID: 35124005

Doi: 10.1016/j.jbc.2022.101684

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Evolution and conserved functionality of organ size and shape regulator PEAPOD

Authors: Ruth Cookson, Somrutai Winichayakul, Hong Xue, Kim Richardson, Roger Moraga, Aurelie Laugraud, Ambarish Biswas, Greg Bryan, Nick Roberts

Journal: PLoS ONE

PubMed ID: 35148336

Doi: 10.1371/journal.pone.0263928

Products & Services: Gene Synthesis

Two-week methotrexate discontinuation in patients with rheumatoid arthritis vaccinated with inactivated SARS-CoV-2 vaccine: a randomised clinical trial

Authors: Carlo Scognamiglio Renner Araujo, Ana Cristina Medeiros-Ribeiro, Carla G S Saad, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Matheus Santos Rodrigues Silva, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Tatiana Pedrosa, Leonard de Vinci Kanda Kupa, Gioanna Zou, Rosa M R Pereira, Clóvis Artur Silva, Nádia Emi Aikawa, Eloisa Bonfa

Journal: Ann Rheum Dis

PubMed ID: 35193873

Doi: 10.1136/annrheumdis-2021-221916

Products & Services: Proteins, Expression, Isolation and Analysis

Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events

Authors: Siew C Ng, Ye Peng, Lin Zhang, Chris Kp Mok, Shilin Zhao, Amy Li, Jessica Yl Ching, Yingzhi Liu, Shuai Yan, Dream L S Chan, Jie Zhu, Chunke Chen, Adrian Ch Fung, Kenneth Ky Wong, David Sc Hui, Francis Kl Chan, Hein M Tun

Journal: Gut

PubMed ID: 35140064

Doi: 10.1136/gutjnl-2021-326563

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Inhibition of base editors with anti-deaminases derived from viruses

Authors: Zhiquan Liu, Siyu Chen, Liangxue Lai, Zhanjun Li

Journal: Nat Commun

PubMed ID: 35105899

Doi: 10.1038/s41467-022-28300-0

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Differences in mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) SARS-CoV-2 vaccine immunogenicity among patients undergoing dialysis

Authors: Kevin Yau, Christopher T Chan, Kento T Abe, Yidi Jiang, Mohammad Atiquzzaman, Sarah I Mullin, Ellen Shadowitz, Lisa Liu, Ema Kostadinovic, Tatjana Sukovic, Anny Gonzalez, Margaret E McGrath-Chong, Matthew J Oliver, Jeffrey Perl, Jerome A Leis, Shelly Bolotin, Vanessa Tran, Adeera Levin, Peter G Blake, Karen Colwill, Anne-Claude Gingras, Michelle A Hladunewich

Journal: CMAJ

PubMed ID: 35115375

Doi: 10.1503/cmaj.211881

Products & Services: Mammalian Expression

The nsp15 Nuclease as a Good Target to Combat SARS-CoV-2: Mechanism of Action and Its Inactivation with FDA-Approved Drugs

Authors: Margarida Saramago, Vanessa G Costa, Caio S Souza, Cátia Bárria, Susana Domingues, Sandra C Viegas, Diana Lousa, Cláudio M Soares, Cecília M Arraiano, Rute G Matos

Journal: Microorganisms

PubMed ID: 35208797

Doi: 10.3390/microorganisms10020342

Products & Services: Gene Synthesis

Intensity and Dynamics of Anti-SARS-CoV-2 Immune Responses after BNT162b2 mRNA Vaccination: Implications for Public Health Vaccination Strategies

Authors: Matthaios Speletas, Ioanna Voulgaridi, Styliani Sarrou, Aikaterini Dadouli, Varvara A Mouchtouri, Dimitrios J Nikoulis, Maria Tsakona, Maria A Kyritsi, Athanasia-Marina Peristeri, Ioanna Avakian, Asimina Nasika, Paraskevi C Fragkou, Charalampos D Moschopoulos, Stamatia Zoubouneli, Ilias Onoufriadis, Lemonia Anagnostopoulos, Alexia Matziri, Georgia Papadamou, Aikaterini Theodoridou, Sotirios Tsiodras, Christos Hadjichristodoulou

Journal: Vaccines (Basel)

PubMed ID: 35214774

Doi: 10.3390/vaccines10020316

The IGFBP3/TMEM219 pathway regulates beta cell homeostasis

Authors: Francesca D'Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F Markmann, Emanuela Orsi, Jan Škrha, Maria Gabriella Camboni, Reza Abdi, A M James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zuccotti, Paolo Fiorina

Journal: Nat Commun

PubMed ID: 35115561

Doi: 10.1038/s41467-022-28360-2

Products & Services: Gene Synthesis

Sensitivity of eight types of ALK fusion variant to alectinib in ALK-transformed cells

Authors: Koh Furugaki, Naoki Harada, Yasushi Yoshimura

Journal: Anticancer Drugs

PubMed ID: 34520436

Doi: 10.1097/CAD.0000000000001249

Products & Services: Mammalian Expression

Chloroplast translational regulation uncovers nonessential photosynthesis genes as key players in plant cold acclimation

Authors: Yang Gao, Wolfram Thiele, Omar Saleh, Federico Scossa, Fayezeh Arabi, Hongmou Zhang, Arun Sampathkumar, Kristina Kühn, Alisdair Fernie, Ralph Bock, Mark A Schöttler, Reimo Zoschke

Journal: Plant Cell

PubMed ID: 35171295

Doi: 10.1093/plcell/koac056

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Olfactory Information Storage Engages Subcortical and Cortical Brain Regions That Support Valence Determination

Authors: Christina Strauch, Thu-Huong Hoang, Frank Angenstein, Denise Manahan-Vaughan

Journal: Cereb Cortex

PubMed ID: 34379749

Doi: 10.1093/cercor/bhab226

Products & Services: Plasmid DNA Preparation

Vaccine Candidate Double Mutant Variants of Enterotoxigenic Heat-Stable Toxin

Authors: Ephrem Debebe Zegeye, Yuleima Diaz, Pål Puntervoll

Journal: Vaccines (Basel)

PubMed ID: 35214698

Doi: 10.3390/vaccines10020241

Products & Services: Mutant Libraries

Structural characterization of a new subclass of panicum mosaic virus-like 3' cap-independent translation enhancer

Authors: Philip Z Johnson, Wojciech K Kasprzak, Bruce A Shapiro, Anne E Simon

Journal: Nucleic Acids Res

PubMed ID: 35104872

Doi: 10.1093/nar/gkac007

Products & Services: Plasmid DNA Preparation

Performance evaluation of four surrogate Virus Neutralization Tests (sVNTs) in comparison to the gold standard test

Authors: Massimo Pieri, Maria Infantino, Mariangela Manfredi, Marzia Nuccetelli, Valentina Grossi, Barbara Lari, Flaminia Tomassetti, Serena Sarubbi, Edda Russo, Amedeo Amedei, Maurizio Benucci, Patrizia Casprini, Lorenzo Stacchini, Concetta Castilletti, Sergio Bernardini

Journal: Front Biosci (Landmark Ed)

PubMed ID: 35227017

Doi: 10.31083/j.fbl2702074

IL-11 Is Elevated and Drives the Profibrotic Phenotype Transition of Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy

Authors: Pengsen Wu, Bingying Lin, Siyu Huang, Jie Meng, Fan Zhang, Min Zhou, Xiangqing Hei, Yu Ke, Huasheng Yang, Danping Huang

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35273577

Doi: 10.3389/fendo.2022.846106

Products & Services: Proteins, Expression, Isolation and Analysis

Nonswelling and Hydrolytically Stable Hydrogels Uncover Cellular Mechanosensing in 3D

Authors: Hongyan Long, Bart E Vos, Timo Betz, Brendon M Baker, Britta Trappmann

Journal: Adv Sci (Weinh)

PubMed ID: 35187856

Doi: 10.1002/advs.202105325

Products & Services: Recombinant Proteins

The Cdc42 GTPase-activating protein Rga6 promotes the cortical localization of septin

Authors: Shengnan Zheng, Biyu Zheng, Zhenbang Liu, Xiaopeng Ma, Xing Liu, Xuebiao Yao, Wenfan Wei, Chuanhai Fu

Journal: J Cell Sci

PubMed ID: 35048989

Doi: 10.1242/jcs.259228

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Fine mapping and cloning of the major seed protein quantitative trait loci on soybean chromosome 20

Authors: Christina E Fliege, Russell A Ward, Pamela Vogel, Hanh Nguyen, Truyen Quach, Ming Guo, João Paulo Gomes Viana, Lucas Borges Dos Santos, James E Specht, Tom E Clemente, Matthew E Hudson, Brian W Diers

Journal: Plant J

PubMed ID: 34978122

Doi: 10.1111/tpj.15658

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Induced ligno-suberin vascular coating and tyramine-derived hydroxycinnamic acid amides restrict Ralstonia solanacearum colonization in resistant tomato

Authors: Anurag Kashyap, Álvaro Luis Jiménez-Jiménez, Weiqi Zhang, Montserrat Capellades, Sumithra Srinivasan, Anna Laromaine, Olga Serra, Mercè Figueras, Jorge Rencoret, Ana Gutiérrez, Marc Valls, Nuria S Coll

Journal: New Phytol

PubMed ID: 35152435

Doi: 10.1111/nph.17982

Products & Services: Monoclonal Antibody Services

Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein

Authors: Oskar Staufer, Kapil Gupta, Jochen Estebano Hernandez Bücher, Fabian Kohler, Christian Sigl, Gunjita Singh, Kate Vasileiou, Ana Yagüe Relimpio, Meline Macher, Sebastian Fabritz, Hendrik Dietz, Elisabetta Ada Cavalcanti Adam, Christiane Schaffitzel, Alessia Ruggieri, Ilia Platzman, Imre Berger, Joachim P Spatz

Journal: Nat Commun

PubMed ID: 35165285

Doi: 10.1038/s41467-022-28446-x

Products & Services: Plasmid DNA Preparation

A Lateral Flow Immunoassay Coupled with a Spectrum-Based Reader for SARS-CoV-2 Neutralizing Antibody Detection

Authors: Rui-Lin Huang, Yi-Chen Fu, Yung-Chih Wang, Chitsung Hong, Wei-Chieh Yang, I-Jen Wang, Jun-Ren Sun, Yunching Chen, Ching-Fen Shen, Chao-Min Cheng

Journal: Vaccines (Basel)

PubMed ID: 35214731

Doi: 10.3390/vaccines10020271

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Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2

Authors: Youwen Zhuang, Lei Wang, Jia Guo, Dapeng Sun, Yue Wang, Weiyi Liu, H Eric Xu, Cheng Zhang

Journal: Nat Commun

PubMed ID: 35217703

Doi: 10.1038/s41467-022-28586-0

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N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum

Authors: Samuel Pazicky, Arne Alder, Haydyn Mertens, Dmitri Svergun, Tim Gilberger, Christian Löw

Journal: Biochem J

PubMed ID: 35023554

Doi: 10.1042/BCJ20210829

Products & Services: Mutant Libraries

Cotranslational interaction of human EBP50 and ezrin overcomes masked binding site during complex assembly

Authors: Krishnendu Khan, Briana Long, Camelia Baleanu-Gogonea, Valentin Gogonea, Gauravi M Deshpande, Kommireddy Vasu, Paul L Fox

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35140182

Doi: 10.1073/pnas.2115799119

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Hot Hydrogen Atom Irradiation of Protonated/Deprotonated Peptide in an Ion Trap Facilitates Fragmentation through Heated Radical Formation

Authors: Daiki Asakawa, Hidenori Takahashi, Shinichi Iwamoto, Koichi Tanaka

Journal: J Am Chem Soc

PubMed ID: 35138819

Doi: 10.1021/jacs.1c11081

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Molecular Characterization and Gene Expression Analysis of Aquaporin in

Authors: Qingli Niu, Rongzeng Hao, Yuping Pan, Zhijie Liu, Jifei Yang, Guiquan Guan, Jianxun Luo, Hong Yin

Journal: Front Physiol

PubMed ID: 35250616

Doi: 10.3389/fphys.2022.811628

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Systemic and Lower Respiratory Tract Immunity to SARS-CoV-2 Omicron and Variants in Pediatric Severe COVID-19 and Mis-C

Authors: Juanjie Tang, Adrienne G Randolph, Tanya Novak, Tracie C Walker, Laura L Loftis, Matt S Zinter, Katherine Irby, Surender Khurana

Journal: Vaccines (Basel)

PubMed ID: 35214728

Doi: 10.3390/vaccines10020270

Products & Services: Mammalian Expression

Endothelial Phospholipase Cγ2 Improves Outcomes of Diabetic Ischemic Limb Rescue Following VEGF Therapy

Authors: Yashika Rustagi, Ahmed S Abouhashem, Priyanka Verma, Sumit S Verma, Edward Hernandez, Sheng Liu, Manishekhar Kumar, Poornachander R Guda, Rajneesh Srivastava, Sujit K Mohanty, Sedat Kacar, Sanskruti Mahajan, Kristen E Wanczyk, Savita Khanna, Michael P Murphy, Gayle M Gordillo, Sashwati Roy, Jun Wan, Chandan K Sen, Kanhaiya Singh

Journal: Diabetes

PubMed ID: 35192691

Doi: 10.2337/db21-0830

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Ratiometric Imaging of Mitochondrial Hydrogen Peroxide in Aβ-Mediated Neurotoxicity

Authors: Xinyu Li, Yiyu Zhang, Hui-Wang Ai

Journal: ACS Sens

PubMed ID: 35226474

Doi: 10.1021/acssensors.1c01381

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Polarized epithelium-sperm co-culture system reveals stimulatory factors for the secretion of mouse epididymal quiescin sulfhydryl oxidase 1

Authors: Yu-Syuan Wei, Wan-Zhen Lin, Tse-En Wang, Wei-Yun Lee, Sheng-Hsiang Li, Fu-Jung Lin, Brett Nixon, Petra Sipilä, Pei-Shiue Tsai

Journal: J Reprod Dev

PubMed ID: 35228412

Doi: 10.1262/jrd.2021-128

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Hsa_circ_0007059 promotes apoptosis and inflammation in cardiomyocytes during ischemia by targeting microRNA-378 and microRNA-383

Authors: Chaorui Xu, Zhuowen Jia, Xuefei Cao, Sha Wang, Jipeng Wang, Liping An

Journal: Cell Cycle

PubMed ID: 35192424

Doi: 10.1080/15384101.2022.2040122

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Rapid colloidal gold immunochromatographic assay for the detection of SARS-CoV-2 total antibodies after vaccination

Authors: Liya Ye, Xinxin Xu, Shanshan Song, Liguang Xu, Hua Kuang, Chuanlai Xu

Journal: J Mater Chem B

PubMed ID: 35212337

Doi: 10.1039/d1tb02521j

Products & Services: Proteins, Expression, Isolation and Analysis

Adaptive evolution of Methylotuvimicrobium alcaliphilum to grow in the presence of rhamnolipids improves fatty acid and rhamnolipid production from CH4

Authors: Deepika Awasthi, Yung-Hsu Tang, Bashar Amer, Edward E K Baidoo, Jennifer Gin, Yan Chen, Christopher J Petzold, Marina Kalyuzhnaya, Steven W Singer

Journal: J Ind Microbiol Biotechnol

PubMed ID: 35134957

Doi: 10.1093/jimb/kuac002

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PAD-2-mediated citrullination of nucleophosmin provides an effective target for tumor immunotherapy

Authors: Ruhul H Choudhury, Peter Symonds, Samantha J Paston, Ian Daniels, Katherine W Cook, Mohamed Gijon, Rachael L Metheringham, Victoria A Brentville, Lindy G Durrant

Journal: J Immunother Cancer

PubMed ID: 35140112

Doi: 10.1136/jitc-2021-003526

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Human cardiac myosin-binding protein C phosphorylation- and mutation-dependent structural dynamics monitored by time-resolved FRET

Authors: Rhye-Samuel Kanassatega, Thomas A Bunch, Victoria C Lepak, Christopher Wang, Brett A Colson

Journal: J Mol Cell Cardiol

PubMed ID: 35227736

Doi: 10.1016/j.yjmcc.2022.02.005

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Highly Stable Buffer-Based Zinc Oxide/Reduced Graphene Oxide Nanosurface Chemistry for Rapid Immunosensing of SARS-CoV-2 Antigens

Authors: Fatemeh Haghayegh, Razieh Salahandish, Mohsen Hassani, Amir Sanati-Nezhad

Journal: ACS Appl Mater Interfaces

PubMed ID: 35172574

Doi: 10.1021/acsami.1c24475

Products & Services: Proteins, Expression, Isolation and Analysis

Identification and mapping of post-transcriptional modifications on the HIV-1 antisense transcript Ast in human cells

Authors: Mariana Estevez, Rui Li, Biplab Paul, Kaveh Daneshvar, Alan C Mullen, Fabio Romerio, Balasubrahmanyam Addepalli

Journal: RNA

PubMed ID: 35168996

Doi: 10.1261/rna.079043.121

Products & Services: Gene Synthesis

APLNR Regulates IFN-γ signaling via β-arrestin 1 mediated JAK-STAT1 pathway in melanoma cells

Authors: Yingying Liu, Xiaochuan Ma, Hui Yang, Xun Li, Yingli Ma, Brandon Ason, Suling Liu, Liaoyuan A Hu

Journal: Biochem J

PubMed ID: 35084016

Doi: 10.1042/BCJ20210813

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Genome-wide identification and functional characterization of gene family reveal their involvement in response to drought stress in

Authors: Guangzhen Shi, Xinxia Zhu

Journal: PeerJ

PubMed ID: 35186477

Doi: 10.7717/peerj.12883

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CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling

Authors: Dan Chen, Yi Zhang, Lian Ji, Yubin Wu

Journal: Cell Biol Int

PubMed ID: 35143104

Doi: 10.1002/cbin.11777

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CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling

Authors: Dan Chen, Yi Zhang, Lian Ji, Yubin Wu

Journal: Cell Biol Int

PubMed ID: 35143104

Doi: 10.1002/cbin.11777

Products & Services: Gene Synthesis

Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance

Authors: Xiaorong Chen, Noah P Bradley, Wei Lu, Katherine L Wahl, Mei Zhang, Hua Yuan, Xian-Feng Hou, Brandt F Eichman, Gong-Li Tang

Journal: Nucleic Acids Res

PubMed ID: 35191495

Doi: 10.1093/nar/gkac085

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Cathepsin B inhibitor alleviates Th1, Th17, and Th22 transcription factor signaling dysregulation in experimental autoimmune encephalomyelitis

Authors: Mushtaq A Ansari, Ahmed Nadeem, Musaad A Alshammari, Sabry M Attia, Saleh A Bakheet, Mohammad R Khan, Thamer H Albekairi, Abdullah F Alasmari, Khaled Alhosaini, Faleh Alqahtani, Haneen A Al-Mazroua, Sheikh F Ahmad

Journal: Exp Neurol

PubMed ID: 35122866

Doi: 10.1016/j.expneurol.2022.113997

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