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The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 - Results from a prospective cohort of outpatient COVID-19 cases
Authors: Kerstin Puchinger, Noemi Castelletti, Raquel Rubio-Acero, Christof Geldmacher, Tabea M Eser, Flora Deák, Ivana Paunovic, Abhishek Bakuli, Elmar Saathoff, Alexander von Meyer, Alisa Markgraf, Philine Falk, Jakob Reich, Friedrich Riess, Philipp Girl, Katharina Müller, Katja Radon, Jessica Michelle Guggenbuehl Noller, Roman Wölfel, Michael Hoelscher, Inge Kroidl, Andreas Wieser, Laura Olbrich
Journal: Virology
PubMed ID: 35245784
Doi: 10.1016/j.virol.2022.02.002
Knockdown of long non‑coding RNA DDX11‑AS1 inhibits the proliferation, migration and paclitaxel resistance of breast cancer cells by upregulating microRNA‑497 expression
Authors: Meng Liang, Beibei Zhu, Min Wang, Ju Jin
Journal: Mol Med Rep
PubMed ID: 35169864
Doi: 10.3892/mmr.2022.12639
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Knockdown of long non‑coding RNA DDX11‑AS1 inhibits the proliferation, migration and paclitaxel resistance of breast cancer cells by upregulating microRNA‑497 expression
Authors: Meng Liang, Beibei Zhu, Min Wang, Ju Jin
Journal: Mol Med Rep
PubMed ID: 35169864
Doi: 10.3892/mmr.2022.12639
Products & Services: Gene Synthesis   
Biochemical Screening of Potent Zika Virus Protease Inhibitors
Authors: Camila Coelho, Gloria Gallo, Leon Hardy, Maria Elena Bottazzi, Claudia Campos, Martin Würtele
Journal: ChemMedChem
PubMed ID: 35104396
Doi: 10.1002/cmdc.202100695
Circular dichroism spectroscopic assessment of structural changes upon protein thermal unfolding at contrasting pH: Comparison with molecular dynamics simulations
Authors: Ponciano García-Gutiérrez, Menandro Camarillo-Cadena, Liliana I Vera-Robles, Rafael A Zubillaga, Andrés Hernández-Arana
Journal: Spectrochim Acta A Mol Biomol Spectrosc
PubMed ID: 35245803
Doi: 10.1016/j.saa.2022.121039
Products & Services: Gene Synthesis   
Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines
Authors: Noëmi Johanna Roos, Riccardo Vincenzo Mancuso, Gerda Mawududzi Sanvee, Jamal Bouitbir, Stephan Krähenbühl
Journal: Food Chem Toxicol
PubMed ID: 35182693
Doi: 10.1016/j.fct.2022.112869
Molecular characterization of the serotonergic transporter from the cestode Echinococcus granulosus: pharmacology and potential role in the nervous system
Authors: Federico Camicia, Hugo R Vaca, Ines Guarnaschelli, Uriel Koziol, Ole V Mortensen, Andreia C K Fontana
Journal: Parasitol Res
PubMed ID: 35169884
Doi: 10.1007/s00436-022-07466-y
Products & Services: Mammalian Expression   
Molecular characterization of the serotonergic transporter from the cestode Echinococcus granulosus: pharmacology and potential role in the nervous system
Authors: Federico Camicia, Hugo R Vaca, Ines Guarnaschelli, Uriel Koziol, Ole V Mortensen, Andreia C K Fontana
Journal: Parasitol Res
PubMed ID: 35169884
Doi: 10.1007/s00436-022-07466-y
Products & Services: Mammalian Expression   
Alterations in calmodulin-cardiac ryanodine receptor molecular recognition in congenital arrhythmias
Authors: Giuditta Dal Cortivo , Carlo Giorgio Barracchia , Valerio Marino , Mariapina D'Onofrio , Daniele Dell'Orco
Journal: Cell Mol Life Sci
PubMed ID: 35133504
Doi: 10.1007/s00018-022-04165-w
Products & Services: Plasmid DNA Preparation   
The Structure of the Arabidopsis PEX4-PEX22 Peroxin Complex—Insights Into Ubiquitination at the Peroxisomal Membrane
Authors: Melissa S Traver , Sarah E Bradford , Jose Luis Olmos Jr , Zachary J Wright , Mitchell D Miller , Weijun Xu , George N Phillips Jr , Bonnie Bartel
Journal: Front Cell Dev Biol
PubMed ID: 35300425
Doi: 10.3389/fcell.2022.838923
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A continuous assay set to screen and characterize novel protein N-acetyltransferases unveils rice GNAT2 activity
Authors: Thomas Asensio , Cyril Dian , Jean-Baptiste Boyer , Frédéric Rivière, Thierry Meinnel , Carmela Giglione
Journal: Front Plant Sci
PubMed ID: 35273627
Doi: 10.3389/fpls.2022.832144
Products & Services: Peptide Synthesis   
Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses
Authors: Brendan T Freitas, Daniil A Ahiadorme, Rahul S Bagul, Ian A Durie, Samir Ghosh, Jarvis Hill, Naomi E Kramer, Jackelyn Murray, Brady M O'Boyle, Emmanuel Onobun, Michael G Pirrone, Justin D Shepard, Suzanne Enos, Yagya P Subedi, Kapil Upadhyaya, Ralph A Tripp, Brian S Cummings, David Crich, Scott D Pegan
Journal: ACS Infect Dis
PubMed ID: 35199517
Doi: 10.1021/acsinfecdis.1c00631
Products & Services: PCR Cloning and Subcloning   
Biochemical and Biophysical Characterisation of the Hepatitis E Virus Guanine-7-Methyltransferase
Authors: Preeti Hooda, Mohd Ishtikhar, Shweta Saraswat, Pooja Bhatia, Deepali Mishra, Aditya Trivedi, Rajkumar Kulandaisamy, Soumya Aggarwal, Manoj Munde, Nemat Ali, Abdullah F AlAsmari, Mohd A Rauf, Krishna K Inampudi, Deepak Sehgal
Journal: Molecules
PubMed ID: 35268608
Doi: 10.3390/molecules27051505
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DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and Developmental Etiology of Mitral Valve Prolapse
Authors: Kelsey S Moore, Reece Moore, Diana B Fulmer, Lilong Guo, Cortney Gensemer, Rebecca Stairley, Janiece Glover, Tyler C Beck, Jordan E Morningstar, Rachel Biggs, Rupak Muhkerjee, Alexander Awgulewitsch, Russell A Norris
Journal: J Cardiovasc Dev Dis
PubMed ID: 35200715
Doi: 10.3390/jcdd9020062
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Comprehensive mapping of SARS-CoV-2 peptide epitopes for development of a highly sensitive serological test for total and neutralizing antibodies
Authors: Garima Kumar, Sarah Sterrett, Lucinda Hall, Edlue Tabengwa, Kazuhito Honjo, Michael Larimer, Randall S Davis, Paul A Goepfert, Benjamin M Larimer
Journal: Protein Eng Des Sel
PubMed ID: 35174857
Doi: 10.1093/protein/gzab033
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Systematic profiling of antigen bias in humoral response against SARS-CoV-2
Authors: Nana Wei, Qiujing Wang, Zhibing Lin, Liyun Xu, Zheen Zhang, Yan Wang, Zhejuan Yang, Lue Li, Tingxiao Zhao, Lu Wang, Haifei Lou, Mingfang Han, Mingliang Ma, Yaosheng Jiang, Jinmiao Lu, Shilan Zhu, Li Cui, Shibo Li
Journal: Virus Res
PubMed ID: 35176329
Doi: 10.1016/j.virusres.2022.198711
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Non-Invasive Monitoring for Rejection in Kidney Transplant Recipients After SARS-CoV-2 mRNA Vaccination
Authors: Ayman Al Jurdi, Rodrigo B Gassen, Thiago J Borges, Zhabiz Solhjou, Frank E Hullekes, Isadora T Lape, Orhan Efe, Areej Alghamdi, Poojan Patel, John Y Choi, Mostafa T Mohammed, Brigid Bohan, Vikram Pattanayak, Ivy Rosales, Paolo Cravedi, Camille N Kotton, Jamil R Azzi, Leonardo V Riella
Journal: Front Immunol
PubMed ID: 35281011
Doi: 10.3389/fimmu.2022.838985
miR-145-5p inhibits the proliferation of glioma stem cells by targeting translationally controlled tumor protein
Authors: Qiujian Zhang, Zhe Cheng, Lei Shi, Gengsheng Mao
Journal: J Cancer
PubMed ID: 35371310
Doi: 10.7150/jca.65543
A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination
Authors: Sarah F Andrews, Julie E Raab, Jason Gorman, Rebecca A Gillespie, Crystal S F Cheung, Reda Rawi, Lauren Y Cominsky, Jeffrey C Boyington, Adrian Creanga, Chen-Hsiang Shen, Darcy R Harris, Adam S Olia, Alexandra F Nazzari, Tongqing Zhou, Katherine V Houser, Grace L Chen, John R Mascola, Barney S Graham, Masaru Kanekiyo, Julie E Ledgerwood, Peter D Kwong, Adrian B McDermott
Journal: Nat Med
PubMed ID: 35115707
Doi: 10.1038/s41591-021-01636-8
Products & Services: Recombinant Antibody Expression   
Enrofloxacin Promotes Plasmid-Mediated Conjugation Transfer of Fluoroquinolone-Resistance Gene
Authors: Yue Zhao, Zhengzheng Cao, Luqing Cui, Tianyu Hu, Kaixuan Guo, Fan Zhang, Xiangru Wang, Zhong Peng, Quan Liu, Menghong Dai
Journal: Front Microbiol
PubMed ID: 35250901
Doi: 10.3389/fmicb.2021.773664
A Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Protects Pigs against PCV2b Challenge and Induces Serum Neutralizing Antibody Response against CSFV
Authors: Selvaraj Pavulraj, Katrin Pannhorst, Rhett W Stout, Daniel B Paulsen, Mariano Carossino, Denise Meyer, Paul Becher, Shafiqul I Chowdhury
Journal: Vaccines (Basel)
PubMed ID: 35214763
Doi: 10.3390/vaccines10020305
Products & Services: Bacterial Expression   
Selective Detection of Serogroup 1 and 5 with a Digital Photocorrosion Biosensor Using Antimicrobial Peptide-Antibody Sandwich Strategy
Authors: M Amirul Islam, Walid M Hassen, Ishika Ishika, Azam F Tayabali, Jan J Dubowski
Journal: Biosensors (Basel)
PubMed ID: 35200365
Doi: 10.3390/bios12020105
Products & Services: Gene Synthesis   
Molecular basis of receptor binding and antibody neutralization of Omicron
Authors: Qin Hong, Wenyu Han, Jiawei Li, Shiqi Xu, Yifan Wang, Cong Xu, Zuyang Li, Yanxing Wang, Chao Zhang, Zhong Huang, Yao Cong
Journal: Nature
PubMed ID: 35228716
Doi: 10.1038/s41586-022-04581-9
Products & Services: Mammalian Expression   
Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress
Authors: Mark Stoneley, Robert F Harvey, Thomas E Mulroney, Ryan Mordue, Rebekah Jukes-Jones, Kelvin Cain, Kathryn S Lilley, Ritwick Sawarkar, Anne E Willis
Journal: Mol Cell
PubMed ID: 35180429
Doi: 10.1016/j.molcel.2022.01.019
Products & Services: Plasmid DNA Preparation   
Far-Red Light Triggered Production of Bispecific T Cell Engagers (BiTEs) from Engineered Cells for Antitumor Application
Authors: Cuilin Zhang, Yingjun Shi, Lingjie Wu, Chenyi Wang, Naishun Liao, Fei Wang, Bixing Zhao, Yingchao Wang, Xiaolong Liu
Journal: ACS Synth Biol
PubMed ID: 35113526
Doi: 10.1021/acssynbio.1c00523
The small heat shock protein HSPB5 attenuates the severity of lupus nephritis in lupus-prone mice
Authors: Spencer Iner Thomas Berg, Justin Knapp, Marsela Braunstein, Cody Shirriff
Journal: Autoimmunity
PubMed ID: 35137667
Doi: 10.1080/08916934.2022.2027921
Products & Services: Endotoxin Detection & Removal System   
Highly Stable Buffer-Based Zinc Oxide/Reduced Graphene Oxide Nanosurface Chemistry for Rapid Immunosensing of SARS-CoV-2 Antigens
Authors: Fatemeh Haghayegh, Razieh Salahandish, Mohsen Hassani, Amir Sanati-Nezhad
Journal: ACS Appl Mater Interfaces
PubMed ID: 35172574
Doi: 10.1021/acsami.1c24475
Development of a Nanoparticle Multiepitope DNA Vaccine against Virulent Infectious Bronchitis Virus Challenge
Authors: Yifeng Qin, Qingyuan Teng, Delan Feng, Yu Pei, Ye Zhao, Guozhong Zhang
Journal: J Immunol
PubMed ID: 35217582
Doi: 10.4049/jimmunol.2100909
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Higher SARS-CoV-2 Spike Binding Antibody Levels and Neutralization Capacity 6 Months after Heterologous Vaccination with AZD1222 and BNT162b2
Authors: Brigitte Müller-Hilke, Franz Mai, Michael Müller, Johann Volzke, Emil C Reisinger
Journal: Vaccines (Basel)
PubMed ID: 35214780
Doi: 10.3390/vaccines10020322
Products & Services: Catalog Peptides   
Development of a Test Card Based on Colloidal Gold Immunochromatographic Strips for Rapid Detection of Antibodies against Theileria equi and Babesia caballi
Authors: Guangpu Yang, Kewei Chen, Wei Guo, Zhe Hu, Ting Qi, Diqiu Liu, Yaoxin Wang, Cheng Du, Xiaojun Wang
Journal: Microbiol Spectr
PubMed ID: 35196786
Doi: 10.1128/spectrum.02411-21
Genome-wide identification and characterization of aquaporins in mangrove plant Kandelia obovata and its role in response to the intertidal environment
Authors: Zejun Guo, Dongna Ma, Jing Li, Mingyue Wei, Ludan Zhang, Lichun Zhou, Xiaoxuan Zhou, Shanshan He, Lin Wang, Yingjia Shen, Qingshun Quinn Li, Hai-Lei Zheng
Journal: Plant Cell Environ
PubMed ID: 35141923
Doi: 10.1111/pce.14286
Products & Services: Protein Tools   
SARS-CoV-2 Infectivity and Antibody Titer Reduction for 6 Months After Second Dose of BNT162b2 mRNA Vaccine in Healthcare Workers: A Prospective Cohort Study
Authors: Namhee Kim, Sue Shin, Dohsik Minn, Seungman Park, Dongheui An, Jae Hyeon Park, Eun Youn Roh, Jong Hyun Yoon, Hyunwoong Park
Journal: J Infect Dis
PubMed ID: 35104871
Doi: 10.1093/infdis/jiac035
SARS-CoV-2 Infectivity and Antibody Titer Reduction for 6 Months After Second Dose of BNT162b2 mRNA Vaccine in Healthcare Workers: A Prospective Cohort Study
Authors: Namhee Kim, Sue Shin, Dohsik Minn, Seungman Park, Dongheui An, Jae Hyeon Park, Eun Youn Roh, Jong Hyun Yoon, Hyunwoong Park
Journal: J Infect Dis
PubMed ID: 35104871
Doi: 10.1093/infdis/jiac035
Biochemical Screening of Potent Zika Virus Protease Inhibitors
Authors: Camila Coelho, Gloria Gallo, Leon Hardy, Maria Elena Bottazzi, Claudia Campos, Martin Würtele
Journal: ChemMedChem
PubMed ID: 35104396
Doi: 10.1002/cmdc.202100695
RNA modifications stabilize the tertiary structure of tRNAfMet by locally increasing conformational dynamics
Authors: Thomas Biedenbänder, Vanessa de Jesus, Martina Schmidt-Dengler, Mark Helm, Björn Corzilius, Boris Fürtig
Journal: Nucleic Acids Res
PubMed ID: 35137185
Doi: 10.1093/nar/gkac040
Products & Services: Plasmid DNA Preparation   
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation
Authors: Prasidda Khadka, Zachary J Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, Frank Dubois, Diana M Carvalho, Juliann Shih, Shu Zhang, Noah F Greenwald, Travis Zack, Ofer Shapira, Kristine Pelton, Rachel Hartley, Heather Bear, Yohanna Georgis, Spandana Jarmale, Randy Melanson, Kevin Bonanno, Kathleen Schoolcraft, Peter G Miller, Alexandra L Condurat, Elizabeth M Gonzalez, Kenin Qian, Eric Morin, Jaldeep Langhnoja, Leslie E Lupien, Veronica Rendo, Jeromy Digiacomo, Dayle Wang, Kevin Zhou, Rushil Kumbhani, Maria E Guerra Garcia, Claire E Sinai, Sarah Becker, Rachel Schneider, Jayne Vogelzang, Karsten Krug, Amy Goodale, Tanaz Abid, Zohra Kalani, Federica Piccioni, Rameen Beroukhim, Nicole S Persky, David E Root, Angel M Carcaboso, Benjamin L Ebert, Christine Fuller, Ozgun Babur, Mark W Kieran, Chris Jones, Hasmik Keshishian, Keith L Ligon, Steven A Carr, Timothy N Phoenix, Pratiti Bandopadhayay
Journal: Nat Commun
PubMed ID: 35105861
Doi: 10.1038/s41467-022-28198-8
Products & Services: Gene Synthesis   
Non-ionic detergent assists formation of supercharged nanodiscs and insertion of membrane proteins
Authors: Frederik G Tidemand, Sara Blemmer, Nicolai T Johansen, Lise Arleth, Martin Cramer Pedersen
Journal: Biochim Biophys Acta Biomembr
PubMed ID: 35182589
Doi: 10.1016/j.bbamem.2022.183884
Products & Services: Custom Vector Construction   
Development of an efficient and precise adenine base editor (ABE) with expanded target range in allotetraploid cotton (Gossypium hirsutum)
Authors: Guanying Wang, Zhongping Xu, Fuqiu Wang, Yuefan Huang, Yanfeng Xin, Sijia Liang, Bo Li, Huan Si, Lin Sun, Qiongqiong Wang, Xiao Ding, Xiangqian Zhu, Luo Chen, Lu Yu, Keith Lindsey, Xianlong Zhang, Shuangxia Jin
Journal: BMC Biol
PubMed ID: 35164736
Doi: 10.1186/s12915-022-01232-3
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Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration
Authors: Elena I Ilina, Camille Cialini, Dietlind L Gerloff, Maitane Duarte Garcia-Escudero, Céline Jeanty, Marie-Laëtitia Thézénas, Antoine Lesur, Vincent Puard, François Bernardin, Alina Moter, Anne Schuster, Monika Dieterle, Anna Golebiewska, Jean-Jacques Gérardy, Gunnar Dittmar, Simone P Niclou, Tanja Müller, Michel Mittelbronn
Journal: iScience
PubMed ID: 35198895
Doi: 10.1016/j.isci.2022.103842
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Characterization and Interaction Analysis of the Secondary Cell Wall Synthesis-Related Transcription Factor in Lamb
Authors: Peizhen Chen, Rong Li, Lingzhi Zhu, Qingqing Hao, Sheng Yao, Jiahe Liu, Kongshu Ji
Journal: Int J Mol Sci
PubMed ID: 35216196
Doi: 10.3390/ijms23042079
Products & Services: Protein Tools   
Structure of a thylakoid-anchored contractile injection system in multicellular cyanobacteria
Authors: Gregor L Weiss, Fabian Eisenstein, Ann-Katrin Kieninger, Jingwei Xu, Hannah A Minas, Milena Gerber, Miki Feldmüller, Iris Maldener, Karl Forchhammer, Martin Pilhofer
Journal: Nat Microbiol
PubMed ID: 35165386
Doi: 10.1038/s41564-021-01055-y
Products & Services: Catalog Antibody   
CD19-targeted BiTE expression by an oncolytic vaccinia virus significantly augments therapeutic efficacy against B-cell lymphoma
Authors: Wen Lei, Qian Ye, Yuanyuan Hao, Jie Chen, Yu Huang, Liu Yang, Shibing Wang, Wenbin Qian
Journal: Blood Cancer J
PubMed ID: 35228544
Doi: 10.1038/s41408-022-00634-4
Products & Services: Plasmid DNA Preparation   
Establishment of a lncRNA-miRNA-mRNA network in a rat model of atrial fibrosis by whole transcriptome sequencing
Authors: Bo Zhao, Weiding Wang, Yu Liu, Siyu Guan, Manman Wang, Fang Song, Wenfeng Shangguan, Shuai Miao, Xiaowei Zhang, Huijia Liu, Enzhao Liu, Xue Liang
Journal: J Interv Card Electrophysiol
PubMed ID: 35124782
Doi: 10.1007/s10840-022-01120-4
Products & Services: Custom DNA/RNA Oligos   
Evaluation of Hydroxycarboxylic Acid Receptor 1 (HCAR1) as a Building Block for Genetically Encoded Extracellular Lactate Biosensors
Authors: Joel Wellbourne-Wood, Marc Briquet, Maxime Alessandri, Francesca Binda, Maylis Touya, Jean-Yves Chatton
Journal: Biosensors (Basel)
PubMed ID: 35323413
Doi: 10.3390/bios12030143
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Immunodominant conformational and linear IgE epitopes lie in a single segment of Ara h 2
Authors: Stéphane Hazebrouck, Sarita U Patil, Blanche Guillon, Nicole Lahood, Stephen C Dreskin, Karine Adel-Patient, Hervé Bernard
Journal: J Allergy Clin Immunol
PubMed ID: 35150723
Doi: 10.1016/j.jaci.2021.12.796
Products & Services: Plasmid DNA Preparation   
Characterization of the antibody response to SARS-CoV-2 in a mildly affected pediatric population
Authors: Sonja Kopanja, Pia Gattinger, Klara Schmidthaler, Justyna Sieber, Katarzyna Niepodziana, Thomas Schlederer, Lukas Weseslindtner, Karin Stiasny, Florian Götzinger, Winfried F Pickl, Thomas Frischer, Rudolf Valenta, Zsolt Szépfalusi
Journal: Pediatr Allergy Immunol
PubMed ID: 35212039
Doi: 10.1111/pai.13737
Products & Services: Bacterial Expression   
From musk to body odor: Decoding olfaction through genetic variation
Authors: Bingjie Li, Marissa L Kamarck, Qianqian Peng, Fei-Ling Lim, Andreas Keller, Monique A M Smeets, Joel D Mainland, Sijia Wang
Journal: PLoS Genet
PubMed ID: 35113854
Doi: 10.1371/journal.pgen.1009564
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Human Milk SARS-CoV-2 Antibodies up to 6 Months After Vaccination
Authors: Stephanie E Perez, Luis Diego Luna Centeno, Wesley A Cheng, Carolyn Jennifer Marentes Ruiz, Yesun Lee, Zion Congrave-Wilson, Rebecca L Powell, Lisa Stellwagen, Pia S Pannaraj
Journal: Pediatrics
PubMed ID: 34981122
Doi: 10.1542/peds.2021-054260
Products & Services: Mammalian Expression   
Identification, functional characterization, assembly and structure of ToxIN type III toxin-antitoxin complex from E coli
Authors: Parthasarathy Manikandan, Sankaran Sandhya, Kavyashree Nadig, Souradip Paul, Narayanaswamy Srinivasan, Ulli Rothweiler, Mahavir Singh
Journal: Nucleic Acids Res
PubMed ID: 35018473
Doi: 10.1093/nar/gkab1264
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