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页码: 126/1028 每页显示数量

Current Status and Future Perspectives on MRNA Drug Manufacturing

Authors: Cameron Webb, Shell Ip, Nuthan V Bathula, Petya Popova, Shekinah K V Soriano, Han Han Ly, Burcu Eryilmaz, Viet Anh Nguyen Huu, Richard Broadhead, Martin Rabel, Ian Villamagna, Suraj Abraham, Vahid Raeesi, Anitha Thomas, Samuel Clarke, Euan C Ramsay, Yvonne Perrie, Anna K Blakney

Journal: Mol Pharm

PubMed ID: 35238565

Doi: 10.1021/acs.molpharmaceut.2c00010

Products & Services: Gene Synthesis

Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention

Authors: Yan-Ruide Li, Zachary Spencer Dunn, Gustavo Garcia, Camille Carmona, Yang Zhou, Derek Lee, Jiaji Yu, Jie Huang, Jocelyn T Kim, Vaithilingaraja Arumugaswami, Pin Wang, Lili Yang

Journal: Stem Cell Res Ther

PubMed ID: 35313965

Doi: 10.1186/s13287-022-02787-2

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SARS-CoV-2 mRNA vaccine induced higher antibody affinity and IgG titers against variants of concern in post-partum vs non-post-partum women

Authors: Youri Lee, Gabrielle Grubbs, Sabrina C Ramelli, Andrea R Levine, Allison Bathula, Kapil Saharia, Madeleine Purcell, Shreya Singireddy, Colleen L Dugan, Lindsey Kirchoff, Allison Lankford, Sarah Cipriano, Ryan A Curto, Jocelyn Wu, Katherine Raja, Emily Kelley, Daniel Herr, Kevin M Vannella, Supriya Ravichandran, Juanjie Tang, Anthony Harris, Mohammad Sajadi, Daniel S Chertow, Alison Grazioli, Surender Khurana

Journal: EBioMedicine

PubMed ID: 35301181

Doi: 10.1016/j.ebiom.2022.103940

Products & Services: Catalog Antibody

The receptor-like cytosolic kinase RIPK activates NADP-malic enzyme 2 to generate NADPH for fueling ROS production

Authors: Binyan Wu, Ping Li, Xiufang Hong, Cuihong Xu, Ran Wang, Yan Liang

Journal: Mol Plant

PubMed ID: 35276409

Doi: 10.1016/j.molp.2022.03.003

Products & Services: Gene Synthesis

Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue

Authors: Federico Cerullo, Sebastian Filbeck, Pratik Rajendra Patil, Hao-Chih Hung, Haifei Xu, Julia Vornberger, Florian W Hofer, Jaro Schmitt, Guenter Kramer, Bernd Bukau, Kay Hofmann, Stefan Pfeffer, Claudio A P Joazeiro

Journal: Nature

PubMed ID: 35264791

Doi: 10.1038/s41586-022-04487-6

Products & Services: Proteins, Expression, Isolation and Analysis

Peptide-based simple detection of SARS-CoV-2 with electrochemical readout

Authors: Dayana Soto, Jahir Orozco

Journal: Anal Chim Acta

PubMed ID: 35414399

Doi: 10.1016/j.aca.2022.339739

Products & Services: Recombinant Antibody Expression

Aquaporin OsPIP2;2 links the H2O2 signal and a membrane-anchored transcription factor to promote plant defense

Authors: Mou Zhang, Haotian Shi, Ningning Li, Nana Wei, Yan Tian, Jinfeng Peng, Xiaochen Chen, Liyuan Zhang, Meixiang Zhang, Hansong Dong

Journal: Plant Physiol

PubMed ID: 34958388

Doi: 10.1093/plphys/kiab604

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Combined Subcutaneous-Intranasal Immunization With Epitope-Based Antigens Elicits Binding and Neutralizing Antibody Responses in Serum and Mucosae Against PRRSV-2 and SARS-CoV-2

Authors: Mario Fragoso-Saavedra, Carmen Ramírez-Estudillo, Diana L Peláez-González, Jorge O Ramos-Flores, Gustavo Torres-Franco, Leandro Núñez-Muñoz, Gabriel Marcelino-Pérez, María G Segura-Covarrubias, Rogelio González-González, Roberto Ruiz-Medrano, Beatriz Xoconostle-Cázares, Amanda Gayosso-Vázquez, Silvia Reyes-Maya, Vianey Ramírez-Andoney, Rogelio A Alonso-Morales, Marco A Vega-López

Journal: Front Immunol

PubMed ID: 35432364

Doi: 10.3389/fimmu.2022.848054

Genetically engineered pH-responsive silk sericin nanospheres with efficient therapeutic effect on ulcerative colitis

Authors: Sheng Xu, Qianqian Yang, Riyuan Wang, Chi Tian, Yanting Ji, Huanhuan Tan, Ping Zhao, David L Kaplan, Feng Wang, Qingyou Xia

Journal: Acta Biomater

PubMed ID: 35288310

Doi: 10.1016/j.actbio.2022.03.012

Products & Services: Proteins, Expression, Isolation and Analysis

Protein chain collapse modulation and folding stimulation by GroEL-ES

Authors: Mohsin M Naqvi, Mario J Avellaneda, Andrew Roth, Eline J Koers, Antoine Roland, Vanda Sunderlikova, Günter Kramer, Hays S Rye, Sander J Tans

Journal: Sci Adv

PubMed ID: 35245117

Doi: 10.1126/sciadv.abl6293

Products & Services: Recombinant Proteins

CTNNBL1 restricts HIV-1 replication by suppressing viral DNA integration into the cell genome

Authors: Guoxin Liang, Yang He, Li Zhao, Jiayue Ouyang, Wenqing Geng, Xiaowei Zhang, Xiaoxu Han, Yongjun Jiang, Haibo Ding, Ying Xiong, Jinxiu Dong, Mei Liu, Hong Shang

Journal: Cell Rep

PubMed ID: 35294870

Doi: 10.1016/j.celrep.2022.110533

Products & Services: Plasmid DNA Preparation

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

Authors: Rachid Essalmani, Jaspreet Jain, Delia Susan-Resiga, Ursula Andréo, Alexandra Evagelidis, Rabeb Mouna Derbali, David N Huynh, Frédéric Dallaire, Mélanie Laporte, Adrien Delpal, Priscila Sutto-Ortiz, Bruno Coutard, Claudine Mapa, Keith Wilcoxen, Etienne Decroly, Tram Nq Pham, Éric A Cohen, Nabil G Seidah

Journal: J Virol

PubMed ID: 35343766

Doi: 10.1128/jvi.00128-22

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CD4+ T cells from COVID-19 mRNA vaccine recipients recognize a conserved epitope present in diverse coronaviruses

Authors: Bezawit A Woldemeskel, Arbor G Dykema, Caroline C Garliss, Saphira Cherfils, Kellie N Smith, Joel N Blankson

Journal: J Clin Invest

PubMed ID: 35061630

Doi: 10.1172/JCI156083

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Therapeutic Effect of Extracellular Vesicles Derived from HIF Prolyl Hydroxylase Domain Enzyme Inhibitor-Treated Cells on Renal Ischemia/Reperfusion Injury

Authors: Zhao-Ying Ding, Tao-Tao Tang, Zuo-Lin Li, Jing-Yuan Cao, Lin-Li Lv, Yi Wen, Bin Wang, Bi-Cheng Liu

Journal: Kidney Dis (Basel)

PubMed ID: 35702708

Doi: 10.1159/000522584

Products & Services: Proteins, Expression, Isolation and Analysis

KIR3DL05 and KIR3DS02 Recognition of a Nonclassical MHC Class I Molecule in the Rhesus Macaque Implicated in Pregnancy Success

Authors: Rachel E Nicholas, Kjell Sandstrom, Jennifer L Anderson, Willow R Smith, Molly Wetzel, Priyankana Banerjee, Sanath Kumar Janaka, David T Evans

Journal: Front Immunol

PubMed ID: 35401580

Doi: 10.3389/fimmu.2022.841136

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RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants

Authors: Qingtai Liang, Yifeng Wang, Shuyuan Zhang, Jing Sun, Wenbo Sun, Jizhou Li, Yaping Liu, Mingxi Li, Lin Cheng, Yuhang Jiang, Ruoke Wang, Rui Zhang, Zihan Yang, Yifei Ren, Peng Chen, Peng Gao, Huayuan Yan, Zheng Zhang, Qi Zhang, Xuanling Shi, Jianbin Wang, Wanli Liu, Xinquan Wang, Bo Ying, Jincun Zhao, Hai Qi, Linqi Zhang

Journal: iScience

PubMed ID: 35291264

Doi: 10.1016/j.isci.2022.104043

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AcrIF5 specifically targets DNA-bound CRISPR-Cas surveillance complex for inhibition

Authors: Yongchao Xie, Laixing Zhang, Zhengyu Gao, Peipei Yin, Hao Wang, Hang Li, Zeliang Chen, Yi Zhang, Maojun Yang, Yue Feng

Journal: Nat Chem Biol

PubMed ID: 35301482

Doi: 10.1038/s41589-022-00995-8

Products & Services: PCR and Cloning

RACK1 Associates with RNA-Binding Proteins Vigilin and SERBP1 to Facilitate Dengue Virus Replication

Authors: Alexis Brugier, Mohamed Lamine Hafirrassou, Marie Pourcelot, Morgane Baldaccini, Vasiliya Kril, Laurine Couture, Beate M Kümmerer, Sarah Gallois-Montbrun, Lucie Bonnet-Madin, Pierre-Olivier Vidalain, Constance Delaugerre, Sébastien Pfeffer, Laurent Meertens, Ali Amara

Journal: J Virol

PubMed ID: 35266803

Doi: 10.1128/jvi.01962-21

Products & Services: Mammalian Expression

FSH blockade improves cognition in mice with Alzheimer's disease

Authors: Jing Xiong, Seong Su Kang, Zhihao Wang, Xia Liu, Tan-Chun Kuo, Funda Korkmaz, Ashley Padilla, Sari Miyashita, Pokman Chan, Zhaohui Zhang, Pavel Katsel, Jocoll Burgess, Anisa Gumerova, Kseniia Ievleva, Damini Sant, Shan-Ping Yu, Valeriia Muradova, Tal Frolinger, Daria Lizneva, Jameel Iqbal, Ki A Goosens, Sakshi Gera, Clifford J Rosen, Vahram Haroutunian, Vitaly Ryu, Tony Yuen, Mone Zaidi, Keqiang Ye

Journal: Nature

PubMed ID: 35236988

Doi: 10.1038/s41586-022-04463-0

Products & Services: Gene Synthesis

Protein Electrostatics Investigated through Paramagnetic NMR for Nonpolar Groups

Authors: Binhan Yu, Channing C Pletka, Junji Iwahara

Journal: J Phys Chem B

PubMed ID: 35266708

Doi: 10.1021/acs.jpcb.1c10930

Products & Services: Mammalian Expression

Melatonin Regulates Lipid Metabolism in Porcine Cumulus-Oocyte Complexes via the Melatonin Receptor 2

Authors: Jun-Xue Jin, Jing-Tao Sun, Chao-Qian Jiang, Hong-Di Cui, Ya Bian, Sanghoon Lee, Lianjin Zhang, Byeong Chun Lee, Zhong-Hua Liu

Journal: Antioxidants (Basel)

PubMed ID: 35453372

Doi: 10.3390/antiox11040687

Products & Services: Proteins, Expression, Isolation and Analysis

Albumin Nanoparticle Endocytosing Subset of Neutrophils for Precision Therapeutic Targeting of Inflammatory Tissue Injury

Authors: Kurt Bachmaier, Andrew Stuart, Abhalaxmi Singh, Amitabha Mukhopadhyay, Sreeparna Chakraborty, Zhigang Hong, Li Wang, Yoshikazu Tsukasaki, Mark Maienschein-Cline, Balaji B Ganesh, Prasad Kanteti, Jalees Rehman, Asrar B Malik

Journal: ACS Nano

PubMed ID: 35230826

Doi: 10.1021/acsnano.1c09762

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Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels

Authors: Neha Singh, András Zeke, Attila Reményi

Journal: Int J Mol Sci

PubMed ID: 35328741

Doi: 10.3390/ijms23063320

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Neddylation is essential for β-catenin degradation in Wnt signaling pathway

Authors: Bojun Wang, Tiantian Wang, Huimin Zhu, Rong Yan, Xinru Li, Chengqian Zhang, Wanyu Tao, Xisong Ke, Piliang Hao, Yi Qu

Journal: Cell Rep

PubMed ID: 35320710

Doi: 10.1016/j.celrep.2022.110538

Products & Services: Plasmid DNA Preparation

Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice

Authors: Saurav S Rout, Yunyun Di, Ulf Dittmer, Kathrin Sutter, Kerry J Lavender

Journal: AIDS

PubMed ID: 35084382

Doi: 10.1097/QAD.0000000000003111

Products & Services: Endotoxin Detection & Removal System

Inhibition of avian influenza virus H9N2 infection by antiviral hexapeptides that target viral attachment to epithelial cells

Authors: Marwa Arbi, Imen Larbi, Jihen Nsiri, Imen El Behi, Ahmed Rejeb, Khaled Miled, Adeljelil Ghram, Mehdi Houimel

Journal: Virus Res

PubMed ID: 35306102

Doi: 10.1016/j.virusres.2022.198745

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Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion

Authors: Nian Jiang, Bowen Xie, Wenwu Xiao, Ming Fan, Shanxiu Xu, Yixin Duan, Yamah Hamsafar, Angela C Evans, Jie Huang, Weibing Zhou, Xuelei Lin, Ningrong Ye, Siyi Wanggou, Wen Chen, Di Jing, Ruben C Fragoso, Brittany N Dugger, Paul F Wilson, Matthew A Coleman, Shuli Xia, Xuejun Li, Lun-Quan Sun, Arta M Monjazeb, Aijun Wang, William J Murphy, Hsing-Jien Kung, Kit S Lam, Hong-Wu Chen, Jian Jian Li

Journal: Nat Commun

PubMed ID: 35314680

Doi: 10.1038/s41467-022-29137-3

Products & Services: Mammalian Expression

Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria

Authors: Huan Yang, Caroline Sibilla, Raymond Liu, Jina Yun, Bruce A Hay, Craig Blackstone, David C Chan, Robert J Harvey, Ming Guo

Journal: Nat Commun

PubMed ID: 35332133

Doi: 10.1038/s41467-022-29071-4

Products & Services: Proteins, Expression, Isolation and Analysis

DNA methylation in Friedreich ataxia silences expression of frataxin isoform E

Authors: Layne N Rodden, Kaitlyn M Gilliam, Christina Lam, Teerapat Rojsajjakul, Clementina Mesaros, Chiara Dionisi, Mark Pook, Massimo Pandolfo, David R Lynch, Ian A Blair, Sanjay I Bidichandani

Journal: Sci Rep

PubMed ID: 35322126

Doi: 10.1038/s41598-022-09002-5

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Identifying Function Determining Residues in Neuroimmune Semaphorin 4A

Authors: Svetlana P Chapoval, Mariah Lee, Aaron Lemmer, Oluwaseyi Ajayi, Xiulan Qi, Andrew F Neuwald, Achsah D Keegan

Journal: Int J Mol Sci

PubMed ID: 35328445

Doi: 10.3390/ijms23063024

Products & Services: Mutant Libraries

Structure of BrxA from Staphylococcus aureus, a bacilliredoxin involved in redox homeostasis in Firmicutes

Authors: Colin S McHugh, Paul D Cook

Journal: Acta Crystallogr F Struct Biol Commun

PubMed ID: 35400666

Doi: 10.1107/S2053230X22002400

Products & Services: Mutant Libraries

MicroRNA-378 contributes to osteoarthritis by regulating chondrocyte autophagy and bone marrow mesenchymal stem cell chondrogenesis

Authors: Lu Feng, Zhengmeng Yang, Yucong Li, Qi Pan, Xiaoting Zhang, Xiaomin Wu, Jessica Hiu Tung Lo, Haixing Wang, Shanshan Bai, Xuan Lu, Ming Wang, Sien Lin, Xiaohua Pan, Gang Li

Journal: Mol Ther Nucleic Acids

PubMed ID: 35474736

Doi: 10.1016/j.omtn.2022.03.016

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Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

Authors: Zi-Wei Ye, Chon Phin Ong, Kaiming Tang, Yilan Fan, Cuiting Luo, Runhong Zhou, Peng Luo, Yun Cheng, Victor Sebastien Gray, Pui Wang, Hin Chu, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Honglin Chen, Zhiwei Chen, Kwok-Yung Yuen, Guang Sheng Ling, Shuofeng Yuan, Dong-Yan Jin

Journal: Cell Mol Immunol

PubMed ID: 35352010

Doi: 10.1038/s41423-022-00855-4

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Use of a Novel Detection Tool to Survey Orthohantaviruses in Wild-Caught Rodent Populations

Authors: Samuel M Goodfellow, Robert A Nofchissey, Chunyan Ye, Jonathan L Dunnum, Joseph A Cook, Steven B Bradfute

Journal: Viruses

PubMed ID: 35458412

Doi: 10.3390/v14040682

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Method for quantification of porcine type I interferon activity using luminescence, by direct and indirect means

Authors: Michael Puckette, J Barrera, M Schwarz, M Rasmussen

Journal: BMC Biotechnol

PubMed ID: 35351081

Doi: 10.1186/s12896-022-00743-9

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Monomodular Pseudomonas aeruginosa phage JG004 lysozyme (Pae87) contains a bacterial surface-active antimicrobial peptide-like region and a possible substrate-binding subdomain

Authors: Roberto Vázquez, Mateo Seoane-Blanco, Virginia Rivero-Buceta, Susana Ruiz, Mark J van Raaij, Pedro García

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35362467

Doi: 10.1107/S2059798322000936

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An ArsRC fusion protein enhances arsenate sensing and detoxification

Authors: Jian Chen, Adriana E Galván, Venkadesh Sarkarai Nadar, Masafumi Yoshinaga, Barry P Rosen

Journal: Environ Microbiol

PubMed ID: 35229439

Doi: 10.1111/1462-2920.15957

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Role of polyphenols in combating Type 2 Diabetes and insulin resistance

Authors: Moyad Shahwan, Fahad Alhumaydhi, Ghulam Md Ashraf, Prince M Z Hasan, Anas Shamsi

Journal: Int J Biol Macromol

PubMed ID: 35247420

Doi: 10.1016/j.ijbiomac.2022.03.004

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Role of polyphenols in combating Type 2 Diabetes and insulin resistance

Authors: Moyad Shahwan, Fahad Alhumaydhi, Ghulam Md Ashraf, Prince M Z Hasan, Anas Shamsi

Journal: Int J Biol Macromol

PubMed ID: 35247420

Doi: 10.1016/j.ijbiomac.2022.03.004

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Resveratrol Blunts Mitochondrial Loss in Slow and Mixed Skeletal Muscle Phenotypes of Non-Human Primates following a Long-Term High Fat/Sugar Diet

Authors: Jon-Philippe K Hyatt, Rafael de Cabo, Julie A Mattison

Journal: J Diet Suppl

PubMed ID: 35229700

Doi: 10.1080/19390211.2022.2039340

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The insecticide β-Cyfluthrin induces acute arrhythmic cardiotoxicity through interaction with NaV15 and ranolazine reverses the phenotype

Authors: Maria Vitoria da Silva, Artur Santos-Miranda, Julliane V Joviano-Santos, Diego Santos Souza, Leisiane Pereira Marques, Jaqueline Oliveira Sarmento, Samuel Santos Beserra, Danilo Roman-Campos

Journal: Clin Sci (Lond)

PubMed ID: 35190819

Doi: 10.1042/CS20211151

Products & Services: Mammalian Expression

ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma

Authors: Ji-Ye Kim, Entaz Bahar, Jung-Yun Lee, Sunhee Chang, Se Hoon Kim, Eun Young Park, Sung-Im Do, Hyonok Yoon, Hyun-Soo Kim

Journal: Cell Death Dis

PubMed ID: 35293383

Doi: 10.1038/s41419-022-04568-4

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A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis

Authors: Yun Ji Park, Richard J Jodts, Jeffrey W Slater, Reyvin M Reyes, Valerie J Winton, Rana A Montaser, Paul M Thomas, William B Dowdle, Anahi Ruiz, Neil L Kelleher, J Martin Bollinger, Carsten Krebs, Brian M Hoffman, Amy C Rosenzweig

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35320042

Doi: 10.1073/pnas.2123566119

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OvoA from ovothiol biosynthesis is a bifunction enzyme: thiol oxygenase and sulfoxide synthase activities

Authors: Ronghai Cheng, Andrew C Weitz, Jared Paris, Yijie Tang, Jingyu Zhang, Heng Song, Nathchar Naowarojna, Kelin Li, Lu Qiao, Juan Lopez, Mark W Grinstaff, Lixin Zhang, Yisong Guo, Sean Elliott, Pinghua Liu

Journal: Chem Sci

PubMed ID: 35432880

Doi: 10.1039/d1sc05479a

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miR-2055 regulates lipid metabolism via fatty acid synthase expression

Authors: Yang Cheng, Tengfei Lu, Junliang Guo, Zhe Lin, Qiao Jin, Xiaoming Zhang, Zhen Zou

Journal: Open Biol

PubMed ID: 35232249

Doi: 10.1098/rsob.210307

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Osteopontin aggravates acute lung injury in influenza virus infection by promoting macrophages necroptosis

Authors: Jinping Wang, Xuehui Li, Yuchong Wang, Yuyu Li, Fan Shi, Hongyan Diao

Journal: Cell Death Discov

PubMed ID: 35246529

Doi: 10.1038/s41420-022-00904-x

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Hepatitis B and Hepatitis C Virus Infection Promote Liver Fibrogenesis through a TGF-b1Induced OCT4/Nanog Pathway

Authors: Wenting Li, Xiaoqiong Duan, Chuanlong Zhu, Xiao Liu, Andre J Jeyarajan, Min Xu, Zeng Tu, Qiuju Sheng, Dong Chen, Chuanwu Zhu, Tuo Shao, Zhimeng Cheng, Shadi Salloum, Esperance A Schaefer, Annie J Kruger, Jacinta A Holmes, Raymond T Chung, Wenyu Lin

Journal: J Immunol

PubMed ID: 35022275

Doi: doi/10.4049/jimmunol.2001453

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CD137 Agonists Targeting CD137-Mediated Negative Regulation Show Enhanced Antitumor Efficacy in Lung Cancer

Authors: Ling Yi , Xin Jin , Jinghui Wang , Zhuohong Yan , Xu Cheng , Tao Wen , Bin Yang , Xiaojue Wang , Nanying Che , Zhidong Liu and Hongtao Zhang

Journal: Frontiers in Immunology

Doi: 10.3389/fimmu.2022.771809

Products & Services: Insect Expression

Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family

Authors: Jianmei Hou , Elizabeth V Nguyen , Minglyanna Surudoi , Michael J Roy , Onisha Patel , Isabelle S Lucet , Xiuquan Ma , Roger J Daly

Journal: Sci Signal

PubMed ID: 35192416

Doi: 10.1126/scisignal.abj3

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Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells

Authors: Shenglong Zhu , Wei Wang , Jingwei Zhang , Siyu Ji , Zhe Jing , Yong Q Chen

Journal: Cell Mol Biol Lett

PubMed ID: 35109789

Doi: 10.1186/s11658-022-00314-y

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