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Detection of SARS-CoV-2 Omicron variant (B11529) infection of white-tailed deer

Authors: Kurt J Vandegrift, Michele Yon, Meera Surendran-Nair, Abhinay Gontu, Saranya Amirthalingam, Ruth H Nissly, Nicole Levine, Tod Stuber, Anthony J DeNicola, Jason R Boulanger, Nathan Kotschwar, Sarah Grimké Aucoin, Richard Simon, Katrina Toal, Randall J Olsen, James J Davis, Dashzeveg Bold, Natasha N Gaudreault, Juergen A Richt, James M Musser, Peter J Hudson, Vivek Kapur, Suresh V Kuchipudi

Journal: biorxiv

PubMed ID: 35169802

Doi: 10.1101/2022.02.04.479189

Lectin galactoside-binding soluble 3 binding protein mediates methotrexate resistance in choriocarcinoma cell lines

Authors: XiaoJing Chen, Yite Xue, Lingfang Wang, Yang Weng, Sen Li, Weiguo Lü, Xing Xie, Xiaodong Cheng

Journal: Bioengineered

PubMed ID: 35038949

Doi: 10.1080/21655979.2021.2022844

Products & Services: Proteins, Expression, Isolation and Analysis

Dimer dissociation is a key energetic event in the fold-switch pathway of KaiB

Authors: Maira Rivera, Pablo Galaz-Davison, Ignacio Retamal-Farfán, Elizabeth A Komives, César A Ramírez-Sarmiento

Journal: Biophys J

PubMed ID: 35151633

Doi: 10.1016/j.bpj.2022.02.012

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Ca Signaling Augmented by ORAI1 Trafficking Regulates the Pathogenic State of Effector T Cells

Authors: Beibei Wu, Jin Seok Woo, Zuoming Sun, Sonal Srikanth, Yousang Gwack

Journal: J Immunol

PubMed ID: 35217583

Doi: 10.4049/jimmunol.2100871

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Genome-wide identification and characterization of AINTEGUMENTA-LIKE (AIL) family genes in apple (Malus domestica Borkh)

Authors: Xiaolei Han, Kai Liu, Gaopeng Yuan, Shanshan He, Peihua Cong, Caixia Zhang

Journal: Genomics

PubMed ID: 35151838

Doi: 10.1016/j.ygeno.2022.110313

Products & Services: Protein Tools

Polycystin-1 and hydrostatic pressure are implicated in glioblastoma pathogenesis in vitro

Authors: Ilianna Zoi, Antonios N Gargalionis, Kostas A Papavassiliou, Narjes Nasiri-Ansari, Christina Piperi, Efthimia K Basdra, Athanasios G Papavassiliou

Journal: J Cell Mol Med

PubMed ID: 35106909

Doi: 10.1111/jcmm.17212

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ROCK2 Polymorphism and Expression Contribute to Increased Susceptibility and Poor Prognosis in Hepatocellular Carcinoma

Authors: Lifeng Qin, Xin Liu, Li'na Lan, Xiaoping Lv

Journal: Int J Gen Med

PubMed ID: 35173468

Doi: 10.2147/IJGM.S343968

Products & Services: GenParts™ DNA Fragments

Safety and immunogenicity of heterologous and homologous inactivated and adenoviral-vectored COVID-19 vaccine regimens in healthy adults: a prospective cohort study

Authors: Nasamon Wanlapakorn, Nungruthai Suntronwong, Harit Phowatthanasathian, Ritthideach Yorsaeng, Preeyaporn Vichaiwattana, Thanunrat Thongmee, Chompoonut Auphimai, Donchida Srimuan, Thaksaporn Thatsanatorn, Suvichada Assawakosri, Sitthichai Kanokudom, Yong Poovorawan

Journal: Hum Vaccin Immunother

PubMed ID: 35209809

Doi: 10.1080/21645515.2022.2029111

High-throughput split-protein profiling by combining transposon mutagenesis and regulated protein-protein interactions with deep sequencing

Authors: Kai Zhou, Thomas Litfin, Md Solayman, Huijun Zhao, Yaoqi Zhou, Jian Zhan

Journal: Int J Biol Macromol

PubMed ID: 35120933

Doi: 10.1016/j.ijbiomac.2022.01.173

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Silencing of IGF2BP1 restrains ox-LDL-induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages

Authors: Mingxin Liu, Guizhou Tao, Yiming Cao, Yu Hu, Zhe Zhang

Journal: J Biochem Mol Toxicol

PubMed ID: 35179253

Doi: 10.1002/jbt.22994

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Inhibition of the Interaction of TREM-1 and eCIRP Attenuates Inflammation and Improves Survival in Hepatic Ischemia/Reperfusion

Authors: Timothy Borjas, Asha Jacob, HaoTing Yen, Vihas Patel, Gene F Coppa, Monowar Aziz, Ping Wang

Journal: Shock

PubMed ID: 34864782

Doi: 10.1097/SHK.0000000000001894

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Cytolysin A-mediated protein exportation efficiency and its role in enhancing the fitness of live recombinant Salmonella Typhi vaccine strain

Authors: F-K Loh, S Nathan, S-C Chow, C-M Fang

Journal: Lett Appl Microbiol

PubMed ID: 35138654

Doi: 10.1111/lam.13669

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Distinct Homologous and Variant-Specific Memory B-Cell and Antibody Response Over Time after SARS-CoV-2 mRNA Vaccination

Authors: Iana H Haralambieva, Jonathon M Monroe, Inna G Ovsyannikova, Diane E Grill, Gregory A Poland, Richard B Kennedy

Journal: J Infect Dis

PubMed ID: 35137144

Doi: 10.1093/infdis/jiac042

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Distinct Homologous and Variant-Specific Memory B-Cell and Antibody Response Over Time after SARS-CoV-2 mRNA Vaccination

Authors: Iana H Haralambieva, Jonathon M Monroe, Inna G Ovsyannikova, Diane E Grill, Gregory A Poland, Richard B Kennedy

Journal: J Infect Dis

PubMed ID: 35137144

Doi: 10.1093/infdis/jiac042

Products & Services: Recombinant Proteins

Ultrasensitive Label-Free DNA Detection Based on Solution-Gated Graphene Transistors Functionalized with Carbon Quantum Dots

Authors: Minghua Deng, Jinhua Li, Bichen Xiao, Zhanpeng Ren, Ziqin Li, Haiyang Yu, Jiashen Li, Jianying Wang, Zhaowei Chen, Xianbao Wang

Journal: Anal Chem

PubMed ID: 35147418

Doi: 10.1021/acs.analchem.1c05309

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Comparison of Neutralizing Antibody Responses at 6 Months Post Vaccination with BNT162b2 and AZD1222

Authors: Evangelos Terpos, Vangelis Karalis, Ioannis Ntanasis-Stathopoulos, Zoi Evangelakou, Maria Gavriatopoulou, Maria S Manola, Panagiotis Malandrakis, Despoina D Gianniou, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Biomedicines

PubMed ID: 35203547

Doi: 10.3390/biomedicines10020338

Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance

Authors: Jacqueto Zephyr, Desaboini Nageswara Rao, Sang V Vo, Mina Henes, Klajdi Kosovrasti, Ashley N Matthew, Adam K Hedger, Jennifer Timm, Elise T Chan, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer

Journal: J Mol Biol

PubMed ID: 35183560

Doi: 10.1016/j.jmb.2022.167503

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An Enhanced Hybrid Screening Approach to Identify Potent Inhibitors for the SARS-CoV-2 Main Protease From the NCI Compound Library

Authors: Shuhua G Li, Kai S Yang, Lauren R Blankenship, Chia-Chuan D Cho, Shiqing Xu, Hongbin Wang, Wenshe Ray Liu

Journal: Front Chem

PubMed ID: 35252116

Doi: 10.3389/fchem.2022.816576

Products & Services: Proteins, Expression, Isolation and Analysis

DNA Vaccines Expressing the Envelope and Membrane Proteins Provide Partial Protection Against SARS-CoV-2 in Mice

Authors: Jinni Chen, Yao Deng, Baoying Huang, Di Han, Wen Wang, Mengjing Huang, Chengcheng Zhai, Zhimin Zhao, Ren Yang, Ying Zhao, Wenling Wang, Desheng Zhai, Wenjie Tan

Journal: Front Immunol

PubMed ID: 35281016

Doi: 10.3389/fimmu.2022.827605

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From In Vitro Data to In Vivo Interspecies Danger Communication: A Study of Chemosensing via the Mouse Grueneberg Ganglion

Authors: Ana Catarina Lopes, Julien Brechbühl, Flavio Ferreira, Marjorie Amez-Droz, Marie-Christine Broillet

Journal: Animals (Basel)

PubMed ID: 35158677

Doi: 10.3390/ani12030356

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Challenges of expressing recombinant human tissue factor as a secreted protein in

Authors: Mohammad Jalili-Nik, Mohammad Soukhtanloo, Majid Mojarrad, Mohammad Hadi Sadeghian, Baratali Mashkani

Journal: Prep Biochem Biotechnol

PubMed ID: 35133942

Doi: 10.1080/10826068.2021.2023823

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Longitudinal analysis of antibody dynamics in COVID-19 convalescents reveals neutralizing responses up to 16 months after infection

Authors: Yang Yang, Minghui Yang, Yun Peng, Yanhua Liang, Jinli Wei, Li Xing, Liping Guo, Xiaohe Li, Jie Li, Jun Wang, Mianhuan Li, Zhixiang Xu, Mingxia Zhang, Fuxiang Wang, Yi Shi, Jing Yuan, Yingxia Liu

Journal: Nat Microbiol

PubMed ID: 35132197

Doi: 10.1038/s41564-021-01051-2

Products & Services: Gene Synthesis

encoding GDP-D-mannose pyrophosphorylase from celery enhanced the accumulation of ascorbic acid and resistance to drought stress in

Authors: Yan-Hua Liu, Hao Wang, Jie-Xia Liu, Sheng Shu, Guo-Fei Tan, Meng-Yao Li, Ao-Qi Duan, Hui Liu, Ai-Sheng Xiong

Journal: PeerJ

PubMed ID: 35233296

Doi: 10.7717/peerj.12976

Products & Services: Recombinant Proteins

encoding GDP-D-mannose pyrophosphorylase from celery enhanced the accumulation of ascorbic acid and resistance to drought stress in

Authors: Yan-Hua Liu, Hao Wang, Jie-Xia Liu, Sheng Shu, Guo-Fei Tan, Meng-Yao Li, Ao-Qi Duan, Hui Liu, Ai-Sheng Xiong

Journal: PeerJ

PubMed ID: 35233296

Doi: 10.7717/peerj.12976

Products & Services: Recombinant Proteins

Rapid, Visual, and Sequence-Specific Detection of in Egg Liquid with vis-NEAA, a CRISPR/Cas12 Empowered New Strategy

Authors: Linlin Bai, Liu Wang, Shuqin Huang, Rong Bai, Xucong Lv, Liping Sun, Fang Zhang, Xiahong Xu

Journal: J Agric Food Chem

PubMed ID: 35138842

Doi: 10.1021/acs.jafc.1c06715

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Immunological characterization of chicken tumor necrosis factor-α (TNF-α) using new sets of monoclonal antibodies specific for poultry TNF-α

Authors: Mingmin Lu, Youngsub Lee, Charles Li, Hyun S Lillehoj

Journal: Dev Comp Immunol

PubMed ID: 35157961

Doi: 10.1016/j.dci.2022.104374

Products & Services: Proteins, Expression, Isolation and Analysis

A broad-spectrum nanobody targeting the C-terminus of the hepatitis B surface antigen for chronic hepatitis B infection therapy

Authors: Yue Wang, Yaxian Mei, Zhenghong Ao, Yuanzhi Chen, Yichao Jiang, Xiaoqing Chen, Ruoyao Qi, Baorong Fu, Jixian Tang, Mujin Fang, Min You, Tianying Zhang, Quan Yuan, Wenxin Luo, Ningshao Xia

Journal: Antiviral Res

PubMed ID: 35183645

Doi: 10.1016/j.antiviral.2022.105265

Products & Services: Proteins, Expression, Isolation and Analysis

Metal Dependence and Functional Diversity of Type I Cas3 Nucleases

Authors: Sining Sun, Zunyu He, Paul Jiang, Rishika Baral, Maria-Eirini Pandelia

Journal: Biochemistry

PubMed ID: 35184547

Doi: 10.1021/acs.biochem.1c00779

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Impact of the clinically approved Petasites hybridus extract Ze 339 on intestinal mechanisms involved in the handling of histamine

Authors: Lina G Mettler, Karin Brecht, Veronika Butterweck, Henriette E Meyer Zu Schwabedissen

Journal: Biomed Pharmacother

PubMed ID: 35149385

Doi: 10.1016/j.biopha.2022.112698

Products & Services: Proteins, Expression, Isolation and Analysis

Aluminum nanoparticles deliver a dual-epitope peptide for enhanced anti-tumor immunotherapy

Authors: Shuting Bai, Hao Jiang, Yuanshuai Song, Yining Zhu, Ming Qin, Chunting He, Guangsheng Du, Xun Sun

Journal: J Control Release

PubMed ID: 35217098

Doi: 10.1016/j.jconrel.2022.02.027

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Calcium and integrin-binding protein 1-like interacting with an integrin α-cytoplasmic domain facilitates cellular immunity in Helicoverpa armigera

Authors: Ming-Ming Zhang, Ling-Ling Luo, Yu Liu, Gui-Jie Wang, Huan-Huan Zheng, Xu-Sheng Liu, Jia-Lin Wang

Journal: Dev Comp Immunol

PubMed ID: 35231466

Doi: 10.1016/j.dci.2022.104379

Products & Services: Recombinant Antibody Expression

IL-9/STAT3/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity

Authors: Liuling Xiao, Xingzhe Ma, Lingqun Ye, Pan Su, Wei Xiong, Enguang Bi, Qiang Wang, Miao Xian, Maojie Yang, Jianfei Qian, Qing Yi

Journal: J Clin Invest

PubMed ID: 35192544

Doi: 10.1172/JCI153247

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TAMpepK Suppresses Metastasis through the Elimination of M2-Like Tumor-Associated Macrophages in Triple-Negative Breast Cancer

Authors: Chanju Lee, Soyoung Kim, Chanmi Jeong, Inhee Cho, Juyeon Jo, Ik-Hwan Han, Hyunsu Bae

Journal: Int J Mol Sci

PubMed ID: 35216272

Doi: 10.3390/ijms23042157

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A genome-wide CRISPR screen identifies HuR as a regulator of apoptosis induced by dsRNA and virus

Authors: Huixin Gao, Yuxia Lin, Changbai Huang, Xiaobo Li, Michael S Diamond, Chao Liu, Rong Zhang, Ping Zhang

Journal: J Cell Sci

PubMed ID: 35112703

Doi: 10.1242/jcs.258855

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WIN site inhibition disrupts a subset of WDR5 function

Authors: Andrew J Siladi, Jing Wang, Andrea C Florian, Lance R Thomas, Joy H Creighton, Brittany K Matlock, David K Flaherty, Shelly L Lorey, Gregory C Howard, Stephen W Fesik, April M Weissmiller, Qi Liu, William P Tansey

Journal: Sci Rep

PubMed ID: 35115608

Doi: 10.1038/s41598-022-05947-9

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TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A

Authors: X Rosa Ma, Mercedes Prudencio, Yuka Koike, Sarat C Vatsavayai, Garam Kim, Fred Harbinski, Adam Briner, Caitlin M Rodriguez, Caiwei Guo, Tetsuya Akiyama, H Broder Schmidt, Beryl B Cummings, David W Wyatt, Katherine Kurylo, Georgiana Miller, Shila Mekhoubad, Nathan Sallee, Gemechu Mekonnen, Laura Ganser, Jack D Rubien, Karen Jansen-West, Casey N Cook, Sarah Pickles, Björn Oskarsson, Neill R Graff-Radford, Bradley F Boeve, David S Knopman, Ronald C Petersen, Dennis W Dickson, James Shorter, Sua Myong, Eric M Green, William W Seeley, Leonard Petrucelli, Aaron D Gitler

Journal: Nature

PubMed ID: 35197626

Doi: 10.1038/s41586-022-04424-7

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In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles

Authors: Fang-Yi Su, Qingyang Henry Zhao, Shreyas N Dahotre, Lena Gamboa, Swapnil Subhash Bawage, Aaron D Silva Trenkle, Ali Zamat, Hathaichanok Phuengkham, Rafi Ahmed, Philip J Santangelo, Gabriel A Kwong

Journal: Sci Adv

PubMed ID: 35196075

Doi: 10.1126/sciadv.abm7950

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Distribution of non-synonymous Vkorc1 mutations in roof rats (Rattus rattus) in France and in Spain - consequences for management

Authors: Marlène Damin-Pernik, Abdessalem Hammed, Ludivine Giraud, Joffrey Goulois, Etienne Benoît, Virginie Lattard

Journal: Pestic Biochem Physiol

PubMed ID: 35430058

Doi: 10.1016/j.pestbp.2022.105052

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A Novel TRIM9 Protein Promotes NF-κB Activation Through Interacting With LvIMD in Shrimp During WSSV Infection

Authors: Mingzhe Sun, Shihao Li, Songjun Jin, Xuechun Li, Jianhai Xiang, Fuhua Li

Journal: Front Immunol

PubMed ID: 35281067

Doi: 10.3389/fimmu.2022.819881

Products & Services: Proteins, Expression, Isolation and Analysis

Non-clinical immunogenicity, biodistribution and toxicology evaluation of a chimpanzee adenovirus-based COVID-19 vaccine in rat and rhesus macaque

Authors: Xuedong Dai, Weijun Zhao, Xin Tong, Wei Liu, Xianhuan Zeng, Xiaohui Duan, Hua Wu, Lili Wang, Zhen Huang, Xinying Tang, Yong Yang

Journal: Arch Toxicol

PubMed ID: 35226134

Doi: 10.1007/s00204-021-03221-x

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SARS-CoV2 variant-specific replicating RNA vaccines protect from disease and pathology and reduce viral shedding following challenge with heterologous SARS-CoV2 variants of concern

Authors: David W Hawman, Kimberly Meade-White, Jacob Archer, Shanna S Leventhal, Drew Wilson, Carl Shaia, Samantha Randall, Amit P Khandhar, Kyle Krieger, Tien-Ying Hsiang, Michael Gale, Peter Berglund, Deborah Heydenburg Fuller, Heinz Feldmann, Jesse Erasmus

Journal: Elife

PubMed ID: 35191378

Doi: 10.7554/eLife.75537

Products & Services: Proteins, Expression, Isolation and Analysis

Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease

Authors: Richard G Lee, Shanti Balasubramaniam, Maike Stentenbach, Tom Kralj, Timothy McCubbin, Benjamin Padman, Janine Smith, Lisa G Riley, Archana Priyadarshi, Liuyu Peng, Madison R Nuske, Richard Webster, Ken Peacock, Philip Roberts, Zornitza Stark, Gabrielle Lemire, Yoko A Ito, Kym M Boycott, Michael T Geraghty, Jan Bert Klinken, Sacha Ferdinandusse, Ying Zhou, Rebecca Walsh, Esteban Marcellin, David R Thorburn, Tony Rosciolli, Janice Fletcher, Oliver Rackham, Frédéric M Vaz, Gavin E Reid, Aleksandra Filipovska

Journal: Hum Mol Genet

PubMed ID: 35147173

Doi: 10.1093/hmg/ddac040

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Functional characterization of tyrosine decarboxylase genes that contribute to acteoside biosynthesis in Rehmannia glutinosa

Authors: Yan Hui Yang, Mu Rong Yang, Jian Yu Zhu, Ke Wei Dong, Yan Jie Yi, Rui Fang Li, Lei Zeng, Chang Fu Zhang

Journal: Planta

PubMed ID: 35147783

Doi: 10.1007/s00425-022-03849-8

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Crp/fnr family protein binds to promoters of atxA and sodmn genes that regulate the expression of exotoxins in Bacillus anthracis

Authors: Divya Goel, Sudhir Kumar, Gopal Krishna Joshi, Prashant Rai, Rakesh Bhatnagar

Journal: Protein Expr Purif

PubMed ID: 35114377

Doi: 10.1016/j.pep.2022.106059

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Genome-wide association study and functional follow-up identifies 14q12 as a candidate risk locus for cervical cancer

Authors: Dhanya Ramachandran, Joe Dennis, Laura Fachal, Peter Schürmann, Kristine Bousset, Fabienne Hülse, Qianqian Mao, Yingying Wang, Matthias Jentschke, Gerd Böhmer, Hans-Georg Strauß, Christine Hirchenhain, Monika Schmidmayr, Florian Müller, Ingo Runnebaum, Alexander Hein, Frederik Stübs, Martin Koch, Matthias Ruebner, Matthias W Beckmann, Peter A Fasching, Alexander Luyten, Matthias Dürst, Peter Hillemanns, Douglas F Easton, Thilo Dörk

Journal: Hum Mol Genet

PubMed ID: 35157032

Doi: 10.1093/hmg/ddac031

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Discovery and Mechanism of Small Molecule Inhibitors Selective for the Chromatin-Binding Domains of Oncogenic UHRF1

Authors: Wallace H Liu, Robert E Miner, Brittany N Albaugh, Gene E Ananiev, Scott A Wildman, John M Denu

Journal: Biochemistry

PubMed ID: 35143176

Doi: 10.1021/acs.biochem.1c00698

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Tetrahymena thermophila granule lattice protein 3 improves solubility of sexual stage malaria antigens expressed in Escherichia coli

Authors: Cengiz Akkale, Donna Marie Cassidy-Hanley, Theodore G Clark

Journal: Protein Expr Purif

PubMed ID: 35134517

Doi: 10.1016/j.pep.2022.106060

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Immunoaffinity monoliths for multiplexed extraction of preterm birth biomarkers from human blood serum in 3D printed microfluidic devices

Authors: Haifa M Almughamsi, Makella K Howell, Samuel R Parry, Joule E Esene, Jacob B Nielsen, Gregory P Nordin, Adam T Woolley

Journal: Analyst

PubMed ID: 35103723

Doi: 10.1039/d1an01365c

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Quantifying Neutralizing Antibodies in Patients with COVID-19 by a Two-Variable Generalized Additive Model

Authors: Kuan-Ting Liu, Yu-Nong Gong, Chung-Guei Huang, Peng-Nien Huang, Kar-Yee Yu, Hou-Chen Lee, Sun-Che Lee, Huan-Jung Chiang, Yu-An Kung, Yueh-Te Lin, Mei-Jen Hsiao, Po-Wei Huang, Sheng-Yu Huang, Hsin-Tai Wu, Chih-Ching Wu, Rei-Lin Kuo, Kuan-Fu Chen, Chuan-Tien Hung, Kasopefoluwa Y Oguntuyo, Christian S Stevens, Shreyas Kowdle, Hsin-Ping Chiu, Benhur Lee, Guang-Wu Chen, Shin-Ru Shih

Journal: mSphere

PubMed ID: 35107336

Doi: 10.1128/msphere.00883-21

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Islet Regeneration and Pancreatic Duct Glands in Human and Experimental Diabetes

Authors: Diletta Overi, Guido Carpino, Marta Moretti, Antonio Franchitto, Lorenzo Nevi, Paolo Onori, Enrico De Smaele, Luca Federici, Daniele Santorelli, Marella Maroder, Lola M Reid, Vincenzo Cardinale, Domenico Alvaro, Eugenio Gaudio

Journal: Front Cell Dev Biol

PubMed ID: 35186929

Doi: 10.3389/fcell.2022.814165

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