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Vaccination after SARS-CoV-2 infection increased antibody avidity against the Omicron variant compared to vaccination alone

Authors: Cas LeMaster, Eric S Geanes, Elizabeth R Fraley, Rangaraj Selvarangan, Todd Bradley

Journal: J Infect Dis

PubMed ID: 35714328

Doi: 10.1093/infdis/jiac247

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miR-452-3p Targets HDAC3 to Inhibit p65 Deacetylation and Activate the NF-κB Signaling Pathway in Early Brain Injury after Subarachnoid Hemorrhage

Authors: Junti Lu, Xiaodong Huang, Aiping Deng, Hong Yao, Gao Wu, Na Wang, Hui Gui, Mojie Ren, Shiwen Guo

Journal: Neurocrit Care

PubMed ID: 35641805

Doi: 10.1007/s12028-022-01509-z

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Disease-linked mutations cause exposure of a protein quality control degron

Authors: Caroline Kampmeyer, Sven Larsen-Ledet, Morten Rose Wagnkilde, Mathias Michelsen, Henriette K M Iversen, Sofie V Nielsen, Søren Lindemose, Alberto Caregnato, Tommer Ravid, Amelie Stein, Kaare Teilum, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen

Journal: Structure

PubMed ID: 35700725

Doi: 10.1016/j.str.2022.05.016

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Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx

Authors: Tae Gun Kang, Kee Woong Kwon, Kyungsoo Kim, Insuk Lee, Myeong Joon Kim, Sang-Jun Ha, Sung Jae Shin

Journal: Nat Commun

PubMed ID: 35672321

Doi: 10.1038/s41467-022-30914-3

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Senescent cells limit p53 activity via multiple mechanisms to remain viable

Authors: Ines Sturmlechner, Chance C Sine, Karthik B Jeganathan, Cheng Zhang, Raul O Fierro Velasco, Darren J Baker, Hu Li, Jan M van Deursen

Journal: Nat Commun

PubMed ID: 35764649

Doi: 10.1038/s41467-022-31239-x

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The Pre-Existing Human Antibody Repertoire to Computationally Optimized Influenza H1 Hemagglutinin Vaccines

Authors: Kaito Nagashima, John V Dzimianski, Julianna Han, Nada Abbadi, Aaron D Gingerich, Fredejah Royer, Sara O'Rourke, Giuseppe A Sautto, Ted M Ross, Andrew B Ward, Rebecca M DuBois, Jarrod J Mousa

Journal: J Immunol

PubMed ID: 35697384

Doi: 10.4049/jimmunol.2101171

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Characterization of inositol lipid metabolism in gut-associated Bacteroidetes

Authors: Stacey L Heaver, Henry H Le, Peijun Tang, Arnaud Baslé, Claudia Mirretta Barone, Dai Long Vu, Jillian L Waters, Jon Marles-Wright, Elizabeth L Johnson, Dominic J Campopiano, Ruth E Ley

Journal: Nat Microbiol

PubMed ID: 35725777

Doi: 10.1038/s41564-022-01152-6

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SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebraﬁsh

Authors: Fang Liang, Yu Zhang, Lin Li, Yexin Yang, Ji-Feng Fei, Yanmei Liu, Wei Qin

Journal: Nat Commun

PubMed ID: 35701400

Doi: 10.1038/s41467-022-31034-8

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Structure−Function Analysis of a Quinone-Dependent Dehydrogenase Capable of Deoxynivalenol Detoxification

Authors: Hua Yang , Ruxue Yan , Yue Li , Zhaoxin Lu , Xiaomei Bie , Haizhen Zhao , Fengxia Lu , Meirong Chen

Journal: J Agric Food Chem

PubMed ID: 35613468

Doi: 10.1021/acs.jafc.2c01083

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Effect of Multivalency on Phase-Separated Droplets Consisting of Poly(PR) Dipeptide Repeats and RNA at the Solid/Liquid Interface

Authors: Chen Chen, Han Jia, Yoshiki Nakamura, Kohsuke Kanekura, Yuhei Hayamizu

Journal: ACS Omega

PubMed ID: 35721931

Doi: 10.1021/acsomega.2c00811

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Template-Assisted Sequencing of SARS-CoV-2 and Influenza Monoclonal Antibodies by Mass Spectrometry

Authors: Michelle V Gadush, Giuseppe A Sautto, Hamssika Chandrasekaran, Alena Bensussan, Ted M Ross, Gregory C Ippolito, Maria D Person

Journal: J Proteome Res

PubMed ID: 35653804

Doi: 10.1021/acs.jproteome.1c00913

Products & Services: Mammalian Expression

Integrating In Vitro and In Silico Analysis of a Cationic Antimicrobial Peptide Interaction with Model Membranes of Colistin-Resistant Strains

Authors: Sandra Patricia Rivera-Sanchez, Iván Darío Ocampo-Ibáñez, Yamil Liscano, Natalia Martínez, Isamar Muñoz, Marcela Manrique-Moreno, Luis Martinez-Martinez, José Oñate-Garzon

Journal: Pharmaceutics

PubMed ID: 35745820

Doi: 10.3390/pharmaceutics14061248

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Author Correction: Development of spirulina for the manufacture and oral delivery of protein therapeutics

Authors: Benjamin W Jester, Hui Zhao, Mesfin Gewe, Thomas Adame, Lisa Perruzza, David T Bolick, Jan Agosti, Nhi Khuong, Rolf Kuestner, Caitlin Gamble, Kendra Cruickshank, Jeremy Ferrara, Rachelle Lim, Troy Paddock, Colin Brady, Stacey Ertel, Miaohua Zhang, Alex Pollock, Jamie Lee, Jian Xiong, Michael Tasch, Tracy Saveria, David Doughty, Jacob Marshall, Damian Carrieri, Lauren Goetsch, Jason Dang, Nathaniel Sanjaya, David Fletcher, Anissa Martinez, Bryce Kadis, Kristjan Sigmar, Esha Afreen, Tammy Nguyen, Amanda Randolph, Alexandria Taber, Ashley Krzeszowski, Brittney Robinett, David B Volkin, Fabio Grassi, Richard Guerrant, Ryo Takeuchi, Brian Finrow, Craig Behnke, James Roberts

Journal: Nat Biotechnol

PubMed ID: 35440781

Doi: 10.1038/s41587-022-01323-0

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The Bufei Jianpi Formula Improves Mucosal Immune Function by Remodeling Gut Microbiota Through the SCFAs/GPR43/NLRP3 Pathway in Chronic Obstructive Pulmonary Disease Rats

Authors: Jing Mao, Ya Li, Qingqing Bian, Yinshuang Xuan, Jingmei Li, Zhikun Wang, Suxiang Feng, Xuefang Liu, Yange Tian, Suyun Li

Journal: Int J Chron Obstruct Pulmon Dis

PubMed ID: 35673595

Doi: 10.2147/COPD.S359428

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Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors

Authors: Jiayue Su, Desheng Liu, Fan Yang, Mei-Qing Zuo, Chang Li, Meng-Qiu Dong, Shan Sun, Sen-Fang Sui

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35733257

Doi: 10.1073/pnas.2200158119

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Increased resistance of SARS-CoV-2 Lambda variant to antibody neutralization

Authors: Huimin Guo, Qing Fan, Shuo Song, Senlin Shen, Bing Zhou, Haiyan Wang, Lin Cheng, Xiangyang Ge, Bin Ju, Zheng Zhang

Journal: JOURNAL OF CLINICAL VIROLOGY

PubMed ID: 35461042

Doi: 10.1016/j.jcv.2022.105162

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Successful Preservation of Native BCR::ABL1 in Chronic Myeloid Leukemia Primary Leukocytes Reveals a Reduced Kinase Activity

Authors: Christian Boni, Massimiliano Bonifacio, Marzia Vezzalini, Luigi Scaffidi, Luisa Tomasello, Laurie L Parker, Diego Boscarino, Dino Paladin, Mauro Krampera, Claudio Sorio

Journal: Front Oncol

PubMed ID: 35756686

Doi: 10.3389/fonc.2022.904510

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Comparative Characterization of Different Molecular Formats of Bispecific Antibodies Targeting EGFR and PD-L1

Authors: Nishant Mohan, Atul Agrawal, Yi Shen, Katie L Winarski, Yukinori Endo, Milos Dokmanovic, Deborah Schmiel, Jiwen Zheng, David S Rotstein, Lorraine C Pelosof, Wen Jin Wu

Journal: Pharmaceutics

PubMed ID: 35890277

Doi: 10.3390/pharmaceutics14071381

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Individual and Synergistic Anti-Coronavirus Activities of SOCS1/3 Antagonist and Interferon α1 Peptides

Authors: Chulbul M Ahmed, Tristan R Grams, David C Bloom, Howard M Johnson, Alfred S Lewin

Journal: Front Immunol

PubMed ID: 35799776

Doi: 10.3389/fimmu.2022.902956

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The Use of Endo-Cellulase and Endo-Xylanase for the Extraction of Apple Pectins as Factors Modifying Their Anticancer Properties and Affecting Their Synergy with the Active Form of Irinotecan

Authors: Jerzy Maksymowicz, Anna Palko-Łabuz, Beata Sobieszczańska, Mateusz Chmielarz, Mirosława Ferens-Sieczkowska, Magdalena Skonieczna, Agnieszka Wikiera, Olga Wesołowska, Kamila Środa-Pomianek

Journal: Pharmaceuticals (Basel)

PubMed ID: 35745651

Doi: 10.3390/ph15060732

Products & Services: Recombinant Proteins

SASH1 knockdown suppresses TRAF6 ubiquitination to regulate hemangioma progression by mediating EZH2 degradation

Authors: Xueyuan Yu, Nuonuo Cong, Xiangyu Liu, Rui Wang, Daxu Li

Journal: Exp Cell Res

PubMed ID: 35772492

Doi: 10.1016/j.yexcr.2022.113270

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Inhibition of histone acetyltransferase GCN5 by a transcription factor FgPacC controls fungal adaption to host-derived iron stress

Authors: Qin Gu, Yujie Wang, Xiaozhen Zhao, Bingqin Yuan, Mengxuan Zhang, Zheng Tan, Xinyue Zhang, Yun Chen, Huijun Wu, Yuming Luo, Nancy P Keller, Xuewen Gao, Zhonghua Ma

Journal: Nucleic Acids Res

PubMed ID: 35687128

Doi: 10.1093/nar/gkac498

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Immunogenicity of Varicella Zoster Virus DNA Vaccines Encoding Glycoprotein E and Immediate Early Protein 63 in Mice

Authors: Jie Liu, Junyang Lin, Linjun Cai, Jie Sun, Xue Ding, Cenrong Wang, Yanchun Wu, Xiaoling Gao, Weiheng Su, Chunlai Jiang

Journal: Viruses

PubMed ID: 35746685

Doi: 10.3390/v14061214

Products & Services: Mammalian Expression

LncRNA RAD51-AS1 Regulates Human Bone Marrow Mesenchymal Stem Cells via Interaction with YBX1 to Ameliorate Osteoporosis

Authors: Beichen Li, Jing Wang, Fangrong Xu, Qinjue Wang, Quan Liu, Guantong Wang, Dengshun Miao, Qiang Sun

Journal: Stem Cell Rev Rep

PubMed ID: 35727431

Doi: 10.1007/s12015-022-10408-x

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Investigating the specificity of endothelin-traps as a potential therapeutic tool for endothelin-1 related disorders

Authors: Arjun Jain, Kristof Bozovicar, Vidhi Mehrotra, Tomaz Bratkovic, Martin H Johnson, Ira Jha

Journal: World J Diabetes

PubMed ID: 35800412

Doi: 10.4239/wjd.v13.i6.434

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Arabidopsis HOPS subunit VPS41 carries out plant-specific roles in vacuolar transport and vegetative growth

Authors: Dong Jiang, Yilin He, Xiangui Zhou, Zhiran Cao, Lei Pang, Sheng Zhong, Liwen Jiang, Ruixi Li

Journal: Plant Physiol

PubMed ID: 35417008

Doi: 10.1093/plphys/kiac167

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A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine

Authors: Jeeva Subbiah, Judy Oh, Ki-Hye Kim, Chong-Hyun Shin, Bo Ryoung Park, Noopur Bhatnagar, Baik-Lin Seong, Bao-Zhong Wang, Sang-Moo Kang

Journal: npj Vaccines

PubMed ID: 35768475

Doi: 10.1038/s41541-022-00498-6

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Sequence-specific H, C and N backbone NMR assignments for the N-terminal IgV-like domain (D1) and full extracellular region (D1D2) of PD-L1

Authors: Kayleigh Walker, Lorna C Waters, Geoff Kelly, Frederick W Muskett, Mark D Carr

Journal: Biomol NMR Assign

PubMed ID: 35675028

Doi: 10.1007/s12104-022-10092-5

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Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses

Authors: Ghizlane Maarifi, Marie-France Martin, Abderezak Zebboudj, Aude Boulay, Pierre Nouaux, Juliette Fernandez, Justine Lagisquet, Dominique Garcin, Raphael Gaudin, Nathalie J Arhel, Sébastien Nisole

Journal: Cell Chem Biol

PubMed ID: 35728599

Doi: 10.1016/j.chembiol.2022.05.009

Products & Services: Recombinant Proteins

Immunological characteristics of MAV/06 strain of varicella-zoster virus vaccine in an animal model

Authors: Duckhyang Shin, Younchul Shin, Eunmi Kim, Hyojung Nam, Haiyan Nan, Jaewoo Lee

Journal: BMC Immunol

PubMed ID: 35658899

Doi: 10.1186/s12865-022-00503-6

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The optimal docking strength for reversibly tethered kinases

Authors: Mateusz Dyla, Nicolás S González Foutel, Daniel E Otzen, Magnus Kjaergaard

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35696590

Doi: 10.1073/pnas.2203098119

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Rnd3 Expression is Necessary to Maintain Mitochondrial Homeostasis but Dispensable for Autophagy

Authors: Cristina Cueto-Ureña, Enric Mocholí, Josep Escrivá-Fernández, Susana González-Granero, Sabina Sánchez-Hernández, Amalia Solana-Orts, Begoña Ballester-Lurbe, Karim Benabdellah, Rosa M Guasch, José Manuel García-Verdugo, Francisco Martín, Paul J Coffer, Ignacio Pérez-Roger, Enric Poch

Journal: Front Cell Dev Biol

PubMed ID: 35832788

Doi: 10.3389/fcell.2022.834561

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The Effects of Qinghao-Kushen and Its Active Compounds on the Biological Characteristics of Liver Cancer Cells

Authors: Jingmin Ji, Zhiqin Zhang, Qing Peng, Liyuan Hao, Yinglin Guo, Yu Xue, Yiwei Liu, Caige Li, Xinli Shi

Journal: Evid Based Complement Alternat Med

PubMed ID: 35722140

Doi: 10.1155/2022/8763510

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Towards a general approach for tailoring the hydrophobic binding site of phenylalanine ammonia-lyases

Authors: Souad Diana Tork, Mădălina Elena Moisă, Lilla Cserepes, Alina Filip, Levente Csaba Nagy, Florin Dan Irimie, László Csaba Bencze

Journal: Sci Rep

PubMed ID: 35739148

Doi: 10.1038/s41598-022-14585-0

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Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes

Authors: Lucy C Walters, Daniel Rozbesky, Karl Harlos, Max Quastel, Hong Sun, Sebastian Springer, Robert P Rambo, Fiyaz Mohammed, E Yvonne Jones, Andrew J McMichael, Geraldine M Gillespie

Journal: Cell Rep

PubMed ID: 35705051

Doi: 10.1016/j.celrep.2022.110959

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Microfluidic T Cell Selection by Cellular Avidity

Authors: Julian F Ashby, Julien Schmidt, Neelima Kc, Armand Kurum, Caroline Koch, Alexandre Harari, Li Tang, Sam H Au

Journal: Adv Healthc Mater

PubMed ID: 35657072

Doi: 10.1002/adhm.202200169

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Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant

Authors: Kirsten E Lyke, Robert L Atmar, Clara Dominguez Islas, Christine M Posavad, Daniel Szydlo, Rahul Paul Chourdhury, Meagan E Deming, Amanda Eaton, Lisa A Jackson, Angela R Branche, Hana M El Sahly, Christina A Rostad, Judith M Martin, Christine Johnston, Richard E Rupp, Mark J Mulligan, Rebecca C Brady, Robert W Frenck, Martín Bäcker, Angelica C Kottkamp, Tara M Babu, Kumaravel Rajakumar, Srilatha Edupuganti, David Dobrzynski, Rhea N Coler, Janet I Archer, Sonja Crandon, Jillian A Zemanek, Elizabeth R Brown, Kathleen M Neuzil, David S Stephens, Diane J Post, Seema U Nayak, Mehul S Suthar, Paul C Roberts, John H Beigel, David C Montefiori

Journal: Cell Rep Med

PubMed ID: 35798000

Doi: 10.1016/j.xcrm.2022.100679

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Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2

Authors: Maria Martinez-Molledo, Emmanuel Nji, Nicolas Reyes

Journal: Nat Struct Mol Biol

PubMed ID: 35710838

Doi: 10.1038/s41594-022-00786-8

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Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity-Making Mutations

Authors: Juan Luis Pacheco-Garcia, Dmitry S Loginov, Ernesto Anoz-Carbonell, Pavla Vankova, Rogelio Palomino-Morales, Eduardo Salido, Petr Man, Milagros Medina, Athi N Naganathan, Angel L Pey

Journal: Antioxidants (Basel)

PubMed ID: 35740007

Doi: 10.3390/antiox11061110

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Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in

Authors: Xiaolu Tai, Yaqun Zhang, Jindong Yao, Xuan Li, Jun Liu, Jiazhen Han, Jianjun Lyu, Gufa Lin, Chao Zhang

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35795143

Doi: 10.3389/fendo.2022.892407

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Deletion of COM donor and acceptor domains and the interaction between modules in bacillomycin D produced by

Authors: Ziyan Lv, Wenjie Ma, Ping Zhang, Zhaoxin Lu, Libang Zhou, Fanqiang Meng, Zuwei Wang, Xiaomei Bie

Journal: Synth Syst Biotechnol

PubMed ID: 35782484

Doi: 10.1016/j.synbio.2022.05.007

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Altered gut microbiota and metabolites profile are associated with reduced bone metabolism in ethanol-induced osteoporosis

Authors: Zhao Liu, Xilin Xu, Yiwei Shen, Yuanyuan Hao, Wenwen Cui, Wenyan Li, Xin Zhang, Hang Lv, Xiaodong Li, Yunlong Hou, Xiaofeng Zhang

Journal: Cell Prolif

PubMed ID: 35688648

Doi: 10.1111/cpr.13245

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mRNA Booster Vaccination Enhances Antibody Responses against SARS-CoV2 Omicron Variant in Individuals Primed with mRNA or Inactivated Virus Vaccines

Authors: Biyan Zhang, Jianxin Huo, Yuhan Huang, Shuan Yong Teo, Kaibo Duan, Yanfeng Li, Lim Kai Toh, Kong Peng Lam, Shengli Xu

Journal: Vaccines (Basel)

PubMed ID: 35891221

Doi: 10.3390/vaccines10071057

RNA Polymerase II Transcription in : TFIIB from Can Replace the Transcriptional Functions of Fission Yeast TFIIB In Vivo and In Vitro

Authors: Diego A Rojas, Fabiola Urbina, Aldo Solari, Edio Maldonado

Journal: Int J Mol Sci

PubMed ID: 35743306

Doi: 10.3390/ijms23126865

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Dynamic transcriptome profiling reveals essential roles of the receptor tyrosine kinases (RTK) family in feather development of duck

Authors: H Liu, Q Xu, Y Xi, S Ma, J Wang, L Bai, C Han, H He, L Li

Journal: Br Poult Sci

PubMed ID: 35383522

Doi: 10.1080/00071668.2022.2061839

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An in-library ligation strategy and its application in CRISPR/Cas9 screening of high-order gRNA combinations

Authors: Zhike Lu, Ke Ni, Yingying Wang, Yangfan Zhou, Yini Li, Jianfeng Yan, Qingkai Song, Min Liu, Yujun Xu, Zhenxing Yu, Tiannan Guo and Lijia Ma

Journal: Nucleic Acids Res

PubMed ID: 35670669

Doi: 10.1093/nar/gkac458

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Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376

Authors: Xiao-dong Luan, Bin-xian Chen, Wei-juan Shang , Wan-chao Yin , Ye Jin , Lei-ke Zhang , H. Eric Xu and Shu-yang Zhang

Journal: Acta pharmacologica Sinica

Doi: 10.1038/s41401-022-00929-z

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Engineering substrate specificity of HAD phosphatases and multienzyme systems development for the thermodynamic-driven manufacturing sugars

Authors: Chaoyu Tian , Jiangang Yang , Cui Liu , Peng Chen , Tong Zhang , Yan Men , Hongwu Ma , Yuanxia Sun, Yanhe Ma

Journal: Nat Commun

PubMed ID: 35739124

Doi: doi.org/10.1038/s41467-022-31371-8

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WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage

Authors: Seong-Su Han , Kuo-Kuang Wen , María L García-Rubio , Marc S Wold , Andrés Aguilera , Wojciech Niedzwiedz , Yatin M Vyas

Journal: Nat Commun

PubMed ID: 35768435

Doi: 10.1038/s41467-022-31415-z.

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Preclinical study of formulated recombinant nucleocapsid protein, the receptor binding domain of the spike protein, and truncated spike (S1) protein as vaccine candidates against COVID-19 in animal models

Authors: Shahram Nazarian, Gholamreza Olad, Raziyeh Abdolhamidi, Mohammad Javad Motamedi, Rouhollah Kazemi, Emad Kordbacheh, Alireza Felagari, Hanieh Olad, Ali Ahmadi, Alireza Bahiraee, Parisa Farahani, Leila Haghighi, Faezeh Hassani, Vahideh Hajhassan, Mona Nadi, Abdolkarim Sheikhi, Jafar Salimian, Jafar Amani

Journal: Mol Immunol

PubMed ID: 35802999

Doi: 10.1016/j.molimm.2022.06.007

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