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Novel method for detecting complement C3 deposition on Staphylococcus aureus

Authors: Toska Wonfor, Shuxian Li, Rhys W Dunphy, Alex Macpherson, Jean van den Elsen, Maisem Laabei

Journal: Sci Rep

PubMed ID: 36130996

Doi: 10.1038/s41598-022-20098-7

Products & Services: Gene Fragments

Phospholipase C-related catalytically inactive protein enhances cisplatin-induced apoptotic cell death

Authors: Satoshi Asano, Yuka Maetani, Yukio Ago, Takashi Kanematsu

Journal: Eur J Pharmacol

PubMed ID: 36108738

Doi: 10.1016/j.ejphar.2022.175273

Products & Services: Gene Synthesis

TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy

Authors: Chengyang Li, Patrick Duckney, Tong Zhang, Yanshu Fu, Xin Li, Johan Kroon, Geert De Jaeger, Yunjiang Cheng, Patrick J Hussey, Pengwei Wang

Journal: Nat Commun

PubMed ID: 36163196

Doi: 10.1038/s41467-022-33402-w

Products & Services: Custom DNA/RNA Oligos

Removal of redox-sensitive Rubisco Activase does not alter Rubisco regulation in soybean

Authors: Christopher M Harvey, Amanda P Cavanagh, Sang Yeol Kim, David A Wright, Ron G Edquilang, Kayla S Shreeves, Juan Alejandro Perdomo, Martin H Spalding, Donald R Ort, Carl J Bernacchi, Steven C Huber

Journal: Photosynth Res

PubMed ID: 36163583

Doi: 10.1007/s11120-022-00962-3

Products & Services: Polyclonal Antibody Services

Nuclear Factor Kappa B Promotes Ferritin Heavy Chain Expression in in Response to Nucleopolyhedrovirus Infection

Authors: Linbao Zhu, Yingxue Liu, Ancheng Wang, Xiya Chen, Handan Zhu, Zhihao Huang, Huihua Cao, Shihuo Liu, Jiaping Xu

Journal: Int J Mol Sci

PubMed ID: 36142290

Doi: 10.3390/ijms231810380

Products & Services: Recombinant Antibody Expression

Tumor-Intrinsic PD-L1 Exerts an Oncogenic Function through the Activation of the Wnt/β-Catenin Pathway in Human Non-Small Cell Lung Cancer

Authors: Yunxia Ma, Rumyana Marinkova, Miljana Nenkov, Lai Jin, Otmar Huber, Jürgen Sonnemann, Natália Peca, Nikolaus Gaßler, Yuan Chen

Journal: Int J Mol Sci

PubMed ID: 36232331

Doi: 10.3390/ijms231911031

Products & Services: Mammalian Expression

A review post-vaccination SARS-CoV-2 serological test: Method and antibody titer response

Authors: Melania Janisha Devi, Shabarni Gaffar, Yeni Wahyuni Hartati

Journal: Anal Biochem

PubMed ID: 36122603

Doi: 10.1016/j.ab.2022.114902

Products & Services: Recombinant Proteins

Targeting of palpable B16-F10 melanoma tumors with polyclonal antibodies on white blood cells

Authors: Girja S Shukla, Stephanie C Pero, Linda Mei, Yu-Jing Sun, David N Krag

Journal: J Immunol Methods

PubMed ID: 36174735

Doi: 10.1016/j.jim.2022.113362

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Preclinical evaluation of new C-11 labeled benzo-1,4-dioxane PET radiotracers for brain α2C adrenergic receptors

Authors: Santosh Alluri，Seth M. Eisenberg，Laurel A. Grisanti，Miles Tanner，Nora D. Volkow，Sung Won Kim，Kun-Eek Kil

Journal: European Journal of Medicinal Chemistry

Doi: doi.org/10.1016/j.ejmech.2022.114764

Products & Services: ORF cDNA Clones/MolecularCloud

E2/E3‐independent ubiquitin‐like protein conjugation by Urm1 is directly coupled to cysteine persulfidation

Authors: Keerthiraju E Ravichandran , Lars Kaduhr , Bozena Skupien-Rabian , Ekaterina Shvetsova , Mikołaj Sokołowski , Ros Cisław Krutyhołowa ,Dominika Kwasna , Cindy Brachmann , Sean Lin , Sebastian Guzman Perez , Piotr Wilk , Manuel Kösters , Przemysław Grudnik , Urszula Jankowska , Sebastian A Leidel , Raffael Schaffrath , Sebastian Glatt

Journal: EMBO J

PubMed ID: 36102610

Doi: 10.15252/embj.2022111318

Products & Services: Gene Synthesis

Engineering a powerful green cell factory for robust photoautotrophic diterpenoid production

Authors: Alexander Einhaus , Jasmin Steube , Robert Ansgar Freudenberg , Jonas Barczyk , Thomas Baier , Olaf Kruse

Journal: Metab Eng

PubMed ID: 35717002

Doi: 10.1016/j.ymben.2022.06.002

Products & Services: Gene Synthesis

Sodium Accumulation in Infected Cells and Ion Transporters Mistargeting in Nodules of : Two Ugly Items That Hinder Coping with Salt Stress Effects

Authors: Natalia A Trifonova, Roman Kamyshinsky, Teodoro Coba de la Peña, Maria I Koroleva, Olga Kulikova, Victoria Lara-Dampier, Pavel Pashkovskiy, Mikhail Presniakov, José J Pueyo, M Mercedes Lucas, Elena E Fedorova

Journal: Int J Mol Sci

PubMed ID: 36142539

Doi: 10.3390/ijms231810618

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Characterizing the Contributions of Various Clostridium perfringens Enterotoxin Properties to and Permeability Effects

Authors: Archana Shrestha, Mauricio A Navarro, Juliann Beingesser, Anibal G Armien, Francisco A Uzal, Bruce A McClane

Journal: mSphere

PubMed ID: 36069435

Doi: 10.1128/msphere.00276-22

Products & Services: Plasmid DNA Preparation

Mechanistic understanding of human SLFN11

Authors: Felix J Metzner, Simon J Wenzl, Michael Kugler, Stefan Krebs, Karl-Peter Hopfner, Katja Lammens

Journal: Nat Commun

PubMed ID: 36115853

Doi: 10.1038/s41467-022-33123-0

Products & Services: Protein and Antibody Isolation

Effect of Foot-and-Mouth Disease Virus 2B Viroporin on Expression and Extraction of Mammalian Cell Culture Produced Foot-and-Mouth Disease Virus-like Particles

Authors: Victoria Primavera, Janine Simmons, Benjamin A Clark, John G Neilan, Michael Puckette

Journal: Vaccines (Basel)

PubMed ID: 36146583

Doi: 10.3390/vaccines10091506

Products & Services: Custom Vector Construction

Automated model-predictive design of synthetic promoters to control transcriptional profiles in bacteria

Authors: Travis L LaFleur, Ayaan Hossain, Howard M Salis

Journal: Nat Commun

PubMed ID: 36056029

Doi: 10.1038/s41467-022-32829-5

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Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variants

Authors: Zhaochun Chen, Peng Zhang, Yumiko Matsuoka, Yaroslav Tsybovsky, Kamille West, Celia Santos, Lisa F Boyd, Hanh Nguyen, Anna Pomerenke, Tyler Stephens, Adam S Olia, Baoshan Zhang, Valeria De Giorgi, Michael R Holbrook, Robin Gross, Elena Postnikova, Nicole L Garza, Reed F Johnson, David H Margulies, Peter D Kwong, Harvey J Alter, Ursula J Buchholz, Paolo Lusso, Patrizia Farci

Journal: Cell Rep

PubMed ID: 36302375

Doi: 10.1016/j.celrep.2022.111528

Products & Services: Mammalian Expression

Enhanced and Potency of a T Cell Epitope in the Ebola Virus Glycoprotein Following Amino Acid Replacement at HLA-A*02:01 Binding Positions

Authors: Sylvie Chabot, Yusra Gimie, Karam Obeid, Jaekwan Kim, Clement A Meseda, Krishnamurthy Konduru, Gerardo Kaplan, Li Sheng Fowler, Jerry P Weir, Keith Peden, Marian E Major

Journal: J Virol

PubMed ID: 36069549

Doi: 10.1128/jvi.01166-21

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An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension

Authors: Elisabeth Fuchs, Imke Rudnik-Jansen, Anders Dinesen, Denis Selnihhin, Ole Aalund Mandrup, Kader Thiam, Jørgen Kjems, Finn Skou Pedersen, Kenneth A Howard

Journal: Acta Biomater

PubMed ID: 36162760

Doi: 10.1016/j.actbio.2022.09.048

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Relaxin-2-secreting CAR-T cells exhibit enhanced efficacy in stromal-rich xenograft tumors

Authors: Hisataka Ogawa; Tomoya Ekawa; Yu Mizote; Takashi Akazawa; Hideaki Tahara

Journal: Frontiers in Immunology

PubMed ID: 40666525

Doi: 10.3389/fimmu.2025.1506204

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Relaxin-2-secreting CAR-T cells exhibit enhanced efficacy in stromal-rich xenograft tumors

Authors: Hisataka Ogawa; Tomoya Ekawa; Yu Mizote; Takashi Akazawa; Hideaki Tahara

Journal: Frontiers in Immunology

PubMed ID: 40666525

Doi: 10.3389/fimmu.2025.1506204

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Relaxin-2-secreting CAR-T cells exhibit enhanced efficacy in stromal-rich xenograft tumors

Authors: Hisataka Ogawa; Tomoya Ekawa; Yu Mizote; Takashi Akazawa; Hideaki Tahara

Journal: Frontiers in Immunology

PubMed ID: 40666525

Doi: 10.3389/fimmu.2025.1506204

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Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1

Authors: Callum Beach; David MacLean; Dominika Majorova; Stavros Melemenidis; Dhanya K. Nambiar; Ryan K. Kim; Gabriel N. Valbuena; Silvia Guglietta; Carsten Krieg; Mahnaz Darvish-Damavandi; Tatsuya Suwa; Alistair Easton; Lily V.S. Hillson; Ashley K. McCulloch; Ross K. McMahon; Kathryn Pennel; Joanne Edwards; Sean M. O Cathail; Campbell S. Roxburgh; Enric Domingo; Eui Jung Moon; Dadi Jiang; Yanyan Jiang; Qingyang Zhang; Albert C. Koong; Trent M. Woodruff; Edward E. Graves; Tim Maughan; Simon J.A. Buczacki; Manuel Stucki; Quynh-Thu Le; Simon J. Leedham; Amato J. Giaccia; Monica M. Olcina

Journal: The Journal of clinical investigation

PubMed ID: 37824211

Doi: 10.1172/JCI168277

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Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide

Authors: Laetitia Coassolo; Niels B. Danneskiold-Sams e; Quennie Nguyen; Amanda Wiggenhorn; Meng Zhao; David Cheng-Hao Wang; David Toomer; Jameel Lone; Yichao Wei; Aayan Patel; Irene Liparulo; Deniz Kavi; Lianna W. Wat; Saranya Chidambaranathan Reghupaty; Julie Jae Kim; Tina Asemi; Ewa Bielczyk-Maczynska; Veronica L. Li; Maria Dolores Moya-Garzon; Nicole A. J. Krentz; Andreas Stahl; Danny Hung-Chieh Chou; Liqun Luo; Katrin J. Svensson

Journal: Nature

PubMed ID: 40044869

Doi: 10.1038/s41586-025-08683-y

H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity

Authors: Huasong Ai , Maoshen Sun , Aijun Liu , Zixian Sun , Tingting Liu , Lin Cao , Lujun Liang , Qian Qu , Zichen Li , Zhiheng Deng , Zebin Tong , Guochao Chu , Xiaolin Tian , Haiteng Deng , Suwen Zhao , Jia-Bin Li , Zhiyong Lou , Lei Liu

Journal: Nat Chem Biol

PubMed ID: 35739357

Doi: 10.1038/s41589-022-01067-7

Products & Services: Gene Synthesis

The SOS response-associated peptidase (SRAP) domain of YedK catalyzes ring opening of abasic sites and reversal of its DNA–protein cross-link

Authors: Katherine A Paulin , David Cortez , Brandt F Eichman

Journal: J Biol Chem

PubMed ID: 35934051

Doi: 10.1016/j.jbc.2022.102307

Products & Services: Peptide Synthesis

Guide RNA engineering enables efficient CRISPR editing with a miniature Syntrophomonas palmitatica Cas12f1 nuclease

Authors: Yujue Wang , Yannan Wang ， Deng Pan , Haopeng Yu , Yifei Zhang , Weizhong Chen , Fan Li , Zhaowei Wu , Quanjiang Ji

Journal: Cell Rep

PubMed ID: 36170834

Doi: doi.org/10.1016/j.celrep.2022.111418

Products & Services: Molecular Biology Reagents

PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design

Authors: Jeetendra Kumar Nag, Hodaya Malka, Shoshana Sedley, Priyanga Appasamy, Tatyana Rudina, Tgst Levi, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, Rachel Bar-Shavit

Journal: Mol Cancer Ther

PubMed ID: 36066448

Doi: 10.1158/1535-7163.MCT-21-0946

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Vaspin Ameliorates Cardiac Remodeling by Suppressing Phosphoinositide 3-Kinase/Protein Kinase B Pathway to Improve Oxidative Stress in Heart Failure Rats

Authors: Mingyue Ji, Yong Li, Yun Liu, Genshan Ma

Journal: J Cardiovasc Pharmacol

PubMed ID: 36067399

Doi: 10.1097/FJC.0000000000001291

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Boosting the Cannabidiol Production in Engineered by Harnessing the Vacuolar Transporter BPT1

Authors: Jie Qiu, Kangxin Hou, Qiang Li, Jialin Chen, Xiwen Li, Hongping Hou, Liqiang Wang, Jia Liu, Qiang Xue, Caixia Wang

Journal: J Agric Food Chem

PubMed ID: 36122349

Doi: 10.1021/acs.jafc.2c05468

Products & Services: Protein and Antibody Isolation

The Musashi proteins direct post-transcriptional control of protein expression and alternate exon splicing in vertebrate photoreceptors

Authors: Fatimah Matalkah, Bohye Jeong, Macie Sheridan, Eric Horstick, Visvanathan Ramamurthy, Peter Stoilov

Journal: Commun Biol

PubMed ID: 36153373

Doi: 10.1038/s42003-022-03990-w

Products & Services: Gene Synthesis

Disease-associated inosine misincorporation into RNA hinders translation

Authors: Jacob H Schroader, Lindsey A Jones, Ryan Meng, Hannah K Shorrock, Jared I Richardson, Sharon M Shaughnessy, Qishan Lin, Thomas J Begley, J Andrew Berglund, Gabriele Fuchs, Mark T Handley, Kaalak Reddy

Journal: Nucleic Acids Res

PubMed ID: 35979951

Doi: 10.1093/nar/gkac709

Products & Services: Custom DNA/RNA Oligos

mRNA-1273 but not BNT162b2 induces antibodies against polyethylene glycol (PEG) contained in mRNA-based vaccine formulations

Authors: Juan Manuel Carreño, Gagandeep Singh, Johnstone Tcheou, Komal Srivastava, Charles Gleason, Hiromi Muramatsu, Parnavi Desai, Judith A Aberg, Rachel L Miller, Paris Study Group, Norbert Pardi, Viviana Simon, Florian Krammer

Journal: Vaccine

PubMed ID: 36115801

Doi: 10.1016/j.vaccine.2022.08.024

Products & Services: Codon Optimization

Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern

Authors: Peifang Sun, Irene Ramos, Camila H Coelho, Alba Grifoni, Corey A Balinsky, Sindhu Vangeti, Alison Tarke, Nathaniel I Bloom, Vihasi Jani, Silvia J Jakubski, David A Boulifard, Elizabeth Cooper, Carl W Goforth, Jan Marayag, Amethyst Marrone, Edgar Nunez, Lindsey White, Chad K Porter, Victor A Sugiharto, Megan Schilling, Avinash S Mahajan, Charmagne Beckett, Alessandro Sette, Stuart C Sealfon, Shane Crotty, Andrew G Letizia

Journal: iScience

PubMed ID: 36168391

Doi: 10.1016/j.isci.2022.105202

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Overexpression of NDST1 Attenuates Fibrotic Response in Murine Adipose-Derived Stem Cells

Authors: Takayoshi Otsuka, Ho-Man Kan, Timothy D Mason, Lakshmi S Nair, Cato T Laurencin

Journal: Stem Cells Dev

PubMed ID: 35920108

Doi: 10.1089/scd.2022.0053

Products & Services: Plasmid DNA Preparation

Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish

Authors: Josiah D Zoodsma, Emma J Keegan, Gabrielle R Moody, Ashwin A Bhandiwad, Amalia J Napoli, Harold A Burgess, Lonnie P Wollmuth, Howard I Sirotkin

Journal: Mol Autism

PubMed ID: 36138431

Doi: 10.1186/s13229-022-00516-3

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Development and optimization of biologically contained Marburg virus for high-throughput antiviral screening

Authors: Bert Vanmechelen, Joren Stroobants, Winston Chiu, Lieve Naesens, Joost Schepers, Kurt Vermeire, Piet Maes

Journal: Antiviral Res

PubMed ID: 36183903

Doi: 10.1016/j.antiviral.2022.105426

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Bombyx mori transcription factor, E74A, beneficially affects BmNPV infection through direct interaction

Authors: Xin Wang, Jun-Li Lv, Shuang Cheng, Zhi-Hao Su, Sheng Qin, Xia Sun, Xu-Dong Tang, Qiu-Ning Liu, Mu-Wang Li, Xue-Yang Wang

Journal: Pest Manag Sci

PubMed ID: 36054174

Doi: 10.1002/ps.7152

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Utilization of the Abbott SARS-CoV-2 IgG II Quant Assay To Identify High-Titer Anti-SARS-CoV-2 Neutralizing Plasma against Wild-Type and Variant SARS-CoV-2 Viruses

Authors: Yi-Chan J Lin, David H Evans, Ninette F Robbins, Guillermo Orjuela, Queenie Hu, Reuben Samson, Kento T Abe, Bhavisha Rathod, Karen Colwill, Anne-Claude Gingras, Ashleigh Tuite, Qi-Long Yi, Sheila F O'Brien, Steven J Drews

Journal: Microbiol Spectr

PubMed ID: 36125288

Doi: 10.1128/spectrum.02811-22

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SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins

Authors: Tyler D R Vance, Patrick Yip, Elisabet Jiménez, Sheng Li, Diana Gawol, James Byrnes, Isabel Usón, Ahmed Ziyyat, Jeffrey E Lee

Journal: Commun Biol

PubMed ID: 36115925

Doi: 10.1038/s42003-022-03883-y

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EuRBG10 involved in indole alkaloids biosynthesis in Eucommia ulmoides induced by drought and salt stresses

Authors: Yanjun Zuo, Bairu Li, Suixia Guan, Jingyu Jia, Xinjie Xu, Zilong Zhang, Zheng Lu, Xin Li, Xinyue Pang

Journal: J Plant Physiol

PubMed ID: 36179396

Doi: 10.1016/j.jplph.2022.153813

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Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia

Authors: Houfang Long, Shengnan Zhang, Shuyi Zeng, Yilun Tong, Jun Liu, Cong Liu, Dan Li

Journal: Cell Rep

PubMed ID: 36130498

Doi: 10.1016/j.celrep.2022.111401

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Protein Stabilization by Alginate Binding and Suppression of Thermal Aggregation

Authors: Roger Chang, Martin Gruebele, Deborah E Leckband

Journal: Biomacromolecules

PubMed ID: 36054903

Doi: 10.1021/acs.biomac.2c00297

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Small Molecule Antibiotics Inhibit Distinct Stages of Bacterial Outer Membrane Protein Assembly

Authors: Janine H Peterson, Matthew Thomas Doyle, Harris D Bernstein

Journal: MBio

PubMed ID: 36165532

Doi: 10.1128/mbio.02286-22

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De Novo design of a humanized antiCD33 antibody-oridonin conjugate for acute myeloid leukemia therapy

Authors: Hui Feng, Yi Liu, Mengyao Zhang, Ruimin Liu, Jincheng Wang, Wenjuan Wang, Pengcheng He, Penghui Zhang, Fan Niu

Journal: Biochem Biophys Res Commun

PubMed ID: 36122452

Doi: 10.1016/j.bbrc.2022.09.032

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Unveiling the Essential Role of Arkadia's Non-RING Elements in the Ubiquitination Process

Authors: Maria Birkou, Georgia N Delegkou, Konstantinos D Marousis, Nefeli Fragkaki, Tamara Toro, Vasso Episkopou, Georgios A Spyroulias

Journal: Int J Mol Sci

PubMed ID: 36142504

Doi: 10.3390/ijms231810585

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Cutaneous kinase activity correlates with treatment outcomes following PI3K delta inhibition in mice with experimental pemphigoid diseases

Authors: Saeedeh Ghorbanalipoor, Shirin Emtenani, Melissa Parker, Mayumi Kamaguchi, Colin Osterloh, Manuela Pigors, Natalie Gross, Stanislav Khil'chenko, Anika Kasprick, Sabrina Patzelt, Diana Wortmann, Ibrahim O Ibrahim, Kentaro Izumi, Stephanie Goletz, Katharina Boch, Kathrin Kalies, Katja Bieber, Paul Smith, Enno Schmidt, Ralf J Ludwig

Journal: Front Immunol

PubMed ID: 36248903

Doi: 10.3389/fimmu.2022.865241

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A bead-based method for high-throughput mapping of the sequence- and force-dependence of T cell activation

Authors: Yinnian Feng, Xiang Zhao, Adam K White, K Christopher Garcia, Polly M Fordyce

Journal: Nat Methods

PubMed ID: 36064771

Doi: 10.1038/s41592-022-01592-2

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A new blocking ELISA for detection of foot-and-mouth disease non-structural protein (NSP) antibodies in a broad host range

Authors: Madhusudan Hosamani, Shreya Gopinath, B P Sreenivasa, Subhasmita Behera, Suresh H Basagoudanavar, Ashok Boora, Durlav P Bora, Pankaj Deka, Veerakyathappa Bhanuprakash, Raj Kumar Singh, Aniket Sanyal, Klaas Weerdmeester, Aldo Dekker

Journal: Appl Microbiol Biotechnol

PubMed ID: 36089639

Doi: 10.1007/s00253-022-12151-2

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Synthetic evolution of herbicide resistance using a T7 RNAP-based random DNA base editor

Authors: Haroon Butt, Jose Luis Moreno Ramirez, Magdy Mahfouz

Journal: Life Sci Alliance

PubMed ID: 36171140

Doi: 10.26508/lsa.202201538

Products & Services: Mutagenesis Services