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Ablation of CD8 T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA1, BA2 and BA3

Authors: Srividhya Swaminathan, Katie E Lineburg, Archana Panikkar, Jyothy Raju, Lawton D Murdolo, Christopher Szeto, Pauline Crooks, Laetitia Le Texier, Sweera Rehan, Michael J Dewar-Oldis, Peter J Barnard, George R Ambalathingal, Michelle A Neller, Kirsty R Short, Stephanie Gras, Rajiv Khanna, Corey Smith

Journal: Nat Commun

PubMed ID: 36302758

Doi: 10.1038/s41467-022-34180-1

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The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

Authors: Lavanya Moparthi, Viktor Sinica, Vamsi K Moparthi, Mohamed Kreir, Thibaut Vignane, Milos R Filipovic, Viktorie Vlachova, Peter M Zygmunt

Journal: Nat Commun

PubMed ID: 36253390

Doi: 10.1038/s41467-022-33876-8

Products & Services: Insect Expression

Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif

Authors: Wenwen Ru, Tomoyuki Koga, Xiaoyang Wang, Qiong Guo, Micah D Gearhart, Shidong Zhao, Mark Murphy, Hiroko Kawakami, Dylan Corcoran, Jiahai Zhang, Zhongliang Zhu, Xuebiao Yao, Yasuhiko Kawakami, Chao Xu

Journal: J Biol Chem

PubMed ID: 36257403

Doi: 10.1016/j.jbc.2022.102607

Products & Services: Mammalian Expression

Tannin Reduces the Incidence of Polyspermic Penetration in Porcine Oocytes

Authors: Jing-Tao Sun, Jia-Hui Liu, Xi-Qing Jiang, Xin Luo, Jin-Dong Yuan, Qi Zhang, Xin-Yue Qi, Sanghoon Lee, Zhong-Hua Liu, Jun-Xue Jin

Journal: Antioxidants (Basel)

PubMed ID: 36290750

Doi: 10.3390/antiox11102027

Products & Services: Protein and Antibody Isolation

Immunization with CRT-Induced Protective Immunity against Infection in BALB/c Mice

Authors: Lujuan Chen, Zhe Cheng, Siqi Xian, Bin Zhan, Zhijian Xu, Yan Yan, Jianfang Chen, Yanhai Wang, Limei Zhao

Journal: Trop Med Infect Dis

PubMed ID: 36288020

Doi: 10.3390/tropicalmed7100279

Products & Services: Endotoxin Detection & Removal System

Genetic variation in gene linked to predisposition of T2DM: A case control study

Authors: Archna Bhargave, Kiran Devi, Imteyaz Ahmad, Anita Yadav, Ranjan Gupta

Journal: J Diabetes Metab Disord

PubMed ID: 36249912

Doi: 10.1007/s40200-022-01131-y

Products & Services: Molecular Biology Tools

Molecular cloning and characterization of a novel bifunctional cellobiohydrolase/β-xylosidase from a metagenomic library of mangrove soil

Authors: Yi-De Liu, Ge Yuan, Yu-Ting An, Zi-Ran Zhu, Gang Li

Journal: Enzyme Microb Technol

PubMed ID: 36265247

Doi: 10.1016/j.enzmictec.2022.110141

Products & Services: Recombinant Proteins

Efficacy and Safety of a Brain-Penetrant Biologic TNF-α Inhibitor in Aged APP/PS1 Mice

Authors: Weijun Ou, Yuu Ohno, Joshua Yang, Devaraj V Chandrashekar, Tamara Abdullah, Jiahong Sun, Riley Murphy, Chuli Roules, Nataraj Jagadeesan, David H Cribbs, Rachita K Sumbria

Journal: Pharmaceutics

PubMed ID: 36297637

Doi: 10.3390/pharmaceutics14102200

Products & Services: Protein and Antibody Isolation

Phytoremediation of isoproturon-contaminated sites by transgenic soybean

Authors: Xiangkun Kong, Na Lv, Songmeng Liu, Hui Xu, Junwei Huang, Xiangting Xie, Qing Tao, Baozhan Wang, Rong Ji, Qun Zhang, Jiandong Jiang

Journal: Plant Biotechnol J

PubMed ID: 36278914

Doi: 10.1111/pbi.13951

Products & Services: Protein and Antibody Isolation

Supramolecular Assembly and Small-Molecule Binding by Protein-Engineered Coiled-Coil Fibers

Authors: Dustin Britton, Julia Monkovic, Sihan Jia, Chengliang Liu, Farbod Mahmoudinobar, Michael Meleties, P Douglas Renfrew, Richard Bonneau, Jin Kim Montclare

Journal: Biomacromolecules

PubMed ID: 36227640

Doi: 10.1021/acs.biomac.2c01031

Products & Services: Plasmid DNA Preparation

Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology

Authors: Anika Heinze, Cara Schuldt, Sharof Khudayberdiev, Bas van Bommel, Daniela Hacker, Toni G Schulz, Ramona Stringhi, Elena Marcello, Marina Mikhaylova, Marco B Rust

Journal: Cell Mol Life Sci

PubMed ID: 36264429

Doi: 10.1007/s00018-022-04593-8

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The seroprevalence of neutralizing antibodies against the adeno-associated virus capsids in Japanese hemophiliacs

Authors: Yuji Kashiwakura, Nemekhbayar Baatartsogt, Shoji Yamazaki, Azusa Nagao, Kagehiro Amano, Nobuaki Suzuki, Tadashi Matsushita, Akihiro Sawada, Satoshi Higasa, Naoya Yamasaki, Teruhisa Fujii, Taemi Ogura, Hideyuki Takedani, Masashi Taki, Takeshi Matsumoto, Jun Yamanouchi, Michio Sakai, Masako Nishikawa, Yutaka Yatomi, Koji Yada, Keiji Nogami, Ryota Watano, Takafumi Hiramoto, Morisada Hayakawa, Nobuhiko Kamoshita, Akihiro Kume, Hiroaki Mizukami, Shizukiyo Ishikawa, Yoichi Sakata, Tsukasa Ohmori

Journal: Mol Ther Methods Clin Dev

PubMed ID: 36381300

Doi: 10.1016/j.omtm.2022.10.014

Products & Services: Plasmid DNA Preparation

Development of a Factor VII Activating Protease (FSAP) generation assay and its application in studying FSAP in venous thrombosis

Authors: Michael Etscheid, Kay-Martin Hanschmann, Per Morten Sandset, Sandip M Kanse

Journal: Thromb Res

PubMed ID: 36265411

Doi: 10.1016/j.thromres.2022.09.027

Products & Services: Gene Synthesis

Intrinsically disordered protein regions are required for cell wall homeostasis in

Authors: Yannick R Brunet, Cameron Habib, Anna P Brogan, Lior Artzi, David Z Rudner

Journal: Genes Dev

PubMed ID: 36265902

Doi: 10.1101/gad.349895.122

Products & Services: Protein and Antibody Isolation

Achieving regioselective materials binding using multidomain peptides

Authors: Ruitao Jin, Nermina Brljak, Robert Sangrigoli, Tiffany R Walsh, Marc R Knecht

Journal: Nanoscale

PubMed ID: 36073151

Doi: 10.1039/d2nr03169h

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Mediator subunit MED1 differentially modulates mutant thyroid hormone receptor intracellular dynamics in Resistance to Thyroid Hormone syndrome

Authors: Moyao Wang, Vincent R Roggero, Lizabeth A Allison

Journal: Mol Cell Endocrinol

PubMed ID: 36191835

Doi: 10.1016/j.mce.2022.111781

Products & Services: Protein and Antibody Isolation

Rational Design of a Thermostable 2' -Deoxyribosyltransferase for Nelarabine Production by Prediction of Disulfide Bond Engineering Sites

Authors: Guillermo Cruz, Javier Acosta, Jose Miguel Mancheño, Jon Del Arco, Jesús Fernández-Lucas

Journal: Int J Mol Sci

PubMed ID: 36233108

Doi: 10.3390/ijms231911806

Products & Services: Gene Synthesis

Paracatalytic induction: Subverting specificity in hedgehog protein autoprocessing with small molecules

Authors: Daniel A. Ciulla; Zihan Xu; John L. Pezzullo; Patricia Dranchak; Chunyu Wang; Jos -Luis Giner; James Inglese; Brian P. Callahan

Journal: Methods in enzymology

PubMed ID: 37245899

Doi: 10.1016/bs.mie.2023.03.001

Products & Services: Protein Electrophoresis and Western

Microarray-guided evaluation of the frequency, B-cell origins, and selectivity of human glycan-binding antibodies reveals new insights and novel antibodies

Authors: J Sebastian Temme, Jennifer A Crainic, Laura M Walker, Weizhun Yang, Zibin Tan, Xuefei Huang, Jeffrey C Gildersleeve

Journal: J Biol Chem

PubMed ID: 36087840

Doi: 10.1016/j.jbc.2022.102468

Products & Services: Plasmid DNA Preparation

Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor

Authors: Xiyuan Zhang, Hannah E Lou, Vishaka Gopalan, Zhihui Liu, Hilda M Jafarah, Haiyan Lei, Paige Jones, Carly M Sayers, Marielle E Yohe, Prashant Chittiboina, Brigitte C Widemann, Carol J Thiele, Michael C Kelly, Sridhar Hannenhalli, Jack F Shern

Journal: Cell Rep

PubMed ID: 36130486

Doi: 10.1016/j.celrep.2022.111363

Products & Services: Custom Vector Construction

Alamandine alleviated heart failure and fibrosis in myocardial infarction mice

Authors: Kun Zhao, Tianhua Xu, Yukang Mao, Xiaoguang Wu, Dongxu Hua, Yanhui Sheng, Peng Li

Journal: Biol Direct

PubMed ID: 36167556

Doi: 10.1186/s13062-022-00338-6

Products & Services: Custom DNA/RNA Oligos

Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors

Authors: Jordan R Willis, Zachary T Berndsen, Krystal M Ma, Jon M Steichen, Torben Schiffner, Elise Landais, Alessia Liguori, Oleksandr Kalyuzhniy, Joel D Allen, Sabyasachi Baboo, Oluwarotimi Omorodion, Jolene K Diedrich, Xiaozhen Hu, Erik Georgeson, Nicole Phelps, Saman Eskandarzadeh, Bettina Groschel, Michael Kubitz, Yumiko Adachi, Tina-Marie Mullin, Nushin B Alavi, Samantha Falcone, Sunny Himansu, Andrea Carfi, Ian A Wilson, John R Yates, James C Paulson, Max Crispin, Andrew B Ward, William R Schief

Journal: Immunity

PubMed ID: 36179689

Doi: 10.1016/j.immuni.2022.09.001

Products & Services: Recombinant Antibody Expression

Intranasal Immunization with Liposome-Displayed Receptor-Binding Domain Induces Mucosal Immunity and Protection against SARS-CoV-2

Authors: Wei-Chiao Huang, Kevin Chiem, Luis Martinez-Sobrido, Jonathan F Lovell

Journal: Pathogens

PubMed ID: 36145467

Doi: 10.3390/pathogens11091035

Products & Services: Catalog Antibodies

Inactivated COVID-19 vaccines: durability of Covaxin/BBV152 induced immunity against variants of concern

Authors: Nathella Pavan Kumar, V V Banurekha, C P Girish Kumar, Arul Nancy, Chandrasekaran Padmapriyadarsini, Sakila Shankar, Luke Elizabeth Hanna, Manoj Murhekar, K R Uma Devi, Subash Babu

Journal: J Travel Med

PubMed ID: 35900009

Doi: 10.1093/jtm/taac088

Products & Services: Recombinant Proteins

High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity

Authors: Rodrigo Vazquez-Lombardi, Johanna S Jung, Fabrice S Schlatter, Anna Mei, Natalia Rodrigues Mantuano, Florian Bieberich, Kai-Lin Hong, Jakub Kucharczyk, Edo Kapetanovic, Erik Aznauryan, Cédric R Weber, Alfred Zippelius, Heinz Läubli, Sai T Reddy

Journal: Immunity

PubMed ID: 36174557

Doi: 10.1016/j.immuni.2022.09.004

Products & Services: Peptide Synthesis

Ras GTPase-activating proteins control neuronal circuit development in barrel cortex layer 4

Authors: Madhura S Rao, Hiromi Mizuno, Takuji Iwasato, Hidenobu Mizuno

Journal: Front Neurosci

PubMed ID: 36188467

Doi: 10.3389/fnins.2022.901774

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Engineered flavivirus vaccines control induction of crossreactive infection-enhancing and -neutralizing antibodies

Authors: Atsushi Yamanaka, Pimploy Rattanaamnuaychai, Mami Matsuda, Ryosuke Suzuki, Yoshiharu Matsuura, Masashi Tatsumi, Eiji Konishi

Journal: Vaccine

PubMed ID: 36109279

Doi: 10.1016/j.vaccine.2022.09.012

Products & Services: Mutagenesis Services

An alternative angiosperm DGAT1 topology and potential motifs in the N-terminus

Authors: Somrutai Winichayakul, Amy Curran, Roger Moraga, Ruth Cookson, Hong Xue, Tracey Crowther, Marissa Roldan, Greg Bryan, Nick Roberts

Journal: Front Plant Sci

PubMed ID: 36186081

Doi: 10.3389/fpls.2022.951389

Products & Services: PCR Cloning and Subcloning

Color-Switchable Nanosilicon Fluorescent Probes

Authors: Huai Chen, Jiang Xu, Yaping Wang, Da Wang, Raquel Ferrer-Espada, Yutong Wang, Jingjian Zhou, Adrián Pedrazo-Tardajos, Mei Yang, Jia-Heng Tan, Xiaoyu Yang, Lei Zhang, Ilya Sychugov, Shoudeng Chen, Sara Bals, Johan Paulsson, Zhenyu Yang

Journal: ACS Nano

PubMed ID: 36107985

Doi: 10.1021/acsnano.2c07443

Products & Services: Catalog Peptides

Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens

Authors: John C Kraft, Minh N Pham, Laila Shehata, Mitch Brinkkemper, Seyhan Boyoglu-Barnum, Kaitlin R Sprouse, Alexandra C Walls, Suna Cheng, Mike Murphy, Deleah Pettie, Maggie Ahlrichs, Claire Sydeman, Max Johnson, Alyssa Blackstone, Daniel Ellis, Rashmi Ravichandran, Brooke Fiala, Samuel Wrenn, Marcos Miranda, Kwinten Sliepen, Philip J M Brouwer, Aleksandar Antanasijevic, David Veesler, Andrew B Ward, Masaru Kanekiyo, Marion Pepper, Rogier W Sanders, Neil P King

Journal: Cell Rep Med

PubMed ID: 36206752

Doi: 10.1016/j.xcrm.2022.100780

Products & Services: Mammalian Expression

The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling

Authors: Manoshi Gayen, Marc R Benoit, Qingyuan Fan, Jacob Hudobenko, Riqiang Yan

Journal: J Biol Chem

PubMed ID: 36162508

Doi: 10.1016/j.jbc.2022.102532

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mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts

Authors: Denzil Furtado, Christina Cortez-Jugo, Ya Hui Hung, Ashley I Bush, Frank Caruso

Journal: Mol Pharm

PubMed ID: 36125338

Doi: 10.1021/acs.molpharmaceut.2c00463

Products & Services: Gene Fragments

A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity

Authors: Lian-Sheng Cheng, Yong-Feng Cheng, Wen-Ting Liu, Aolin Shen, Dayan Zhang, Tingjuan Xu, Wu Yin, Min Cheng, Xiaopeng Ma, Fengrong Wang, Qun Zhao, Xiaoli Zeng, Yan Zhang, Guodong Shen

Journal: J Transl Med

PubMed ID: 36076251

Doi: 10.1186/s12967-022-03619-w

Products & Services: Mammalian Expression

Translation inhibition efficacy does not determine the Plasmodium berghei liver stage antiplasmodial efficacy of protein synthesis inhibitors

Authors: James L. McLellan; Kirsten K. Hanson

Journal: biorxiv

PubMed ID: 38106175

Doi: 10.1101/2023.12.07.570699

Relaxin-2-secreting CAR-T cells exhibit enhanced efficacy in stromal-rich xenograft tumors

Authors: Hisataka Ogawa; Tomoya Ekawa; Yu Mizote; Takashi Akazawa; Hideaki Tahara

Journal: Frontiers in Immunology

PubMed ID: 40666525

Doi: 10.3389/fimmu.2025.1506204

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Relaxin-2-secreting CAR-T cells exhibit enhanced efficacy in stromal-rich xenograft tumors

Authors: Hisataka Ogawa; Tomoya Ekawa; Yu Mizote; Takashi Akazawa; Hideaki Tahara

Journal: Frontiers in Immunology

PubMed ID: 40666525

Doi: 10.3389/fimmu.2025.1506204

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Relaxin-2-secreting CAR-T cells exhibit enhanced efficacy in stromal-rich xenograft tumors

Authors: Hisataka Ogawa; Tomoya Ekawa; Yu Mizote; Takashi Akazawa; Hideaki Tahara

Journal: Frontiers in Immunology

PubMed ID: 40666525

Doi: 10.3389/fimmu.2025.1506204

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Viruses inhibit TIR gcADPR signaling to overcome bacterial defense

Authors: Azita Leavitt, Erez Yirmiya, Gil Amitai, Allen Lu, Jeremy Garb, Ehud Herbst, Benjamin R Morehouse, Samuel J Hobbs, Sadie P Antine, Zhen-Yu J Sun, Philip J Kranzusch, Rotem Sorek

Journal: Nature

PubMed ID: 36174646

Doi: 10.1038/s41586-022-05375-9

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Glycosyltransferase engineering and multi-glycosylation routes development facilitating synthesis of high-intensity sweetener mogrosides

Authors: Jiao Li, Shicheng Mu, Jiangang Yang, Cui Liu, Yanfei Zhang, Peng Chen, Yan Zeng, Yueming Zhu, Yuanxia Sun

Journal: iScience

PubMed ID: 36248741

Doi: 10.1016/j.isci.2022.105222

Products & Services: Mutant Libraries

Evaluating Primary Endpoints for COVID-19 Therapeutic Trials to Assess Recovery

Authors: David J Douin, Lianne Siegel, Greg Grandits, Andrew Phillips, Neil R Aggarwal, Jason Baker, Samuel M Brown, Christina C Chang, Anna L Goodman, Birgit Grund, Elizabeth S Higgs, Catherine L Hough, Daniel D Murray, Roger Paredes, Mahesh Parmar, Sarah Pett, Mark N Polizzotto, Uriel Sandkovsky, Wesley H Self, Barnaby E Young, Abdel G Babiker, Victoria J Davey, Virginia Kan, Annetine C Gelijns, Gail Matthews, B Taylor Thompson, H Clifford Lane, James D Neaton, Jens D Lundgren, Adit A Ginde

Journal: Am J Respir Crit Care Med

PubMed ID: 35580040

Doi: 10.1164/rccm.202112-2836OC

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Impact of hypertension on long-term humoral and cellular response to SARS-CoV-2 infection

Authors: Chang Chu, Anne Schönbrunn, Kristin Klemm, Volker von Baehr, Bernhard K Krämer, Saban Elitok, Berthold Hocher

Journal: Front Immunol

PubMed ID: 36119050

Doi: 10.3389/fimmu.2022.915001

The first molecular identification and phylogenetic analysis of tick-borne pathogens in captive wild animals from Lohi Bher zoo, Pakistan

Authors: Muhammad Uzair Mukhtar, Naveed Iqbal, Jifei Yang, Zeeshan Nawaz, Tan Li Peng

Journal: Parasitol Res

PubMed ID: 36114837

Doi: 10.1007/s00436-022-07666-6

Products & Services: DNA Sequencing

DNA Prime and Recombinant Protein Boost Vaccination Confers Chickens with Enhanced Protection against Chicken Infectious Anemia Virus

Authors: Ling Liu, Mingrong Yin, Yang Li, Hong Su, Lichun Fang, Xiaolong Sun, Shuang Chang, Peng Zhao, Yixin Wang

Journal: Viruses

PubMed ID: 36298670

Doi: 10.3390/v14102115

Products & Services: Protein and Antibody Isolation

Preclinical evaluation of new C-11 labeled benzo-1,4-dioxane PET radiotracers for brain α2C adrenergic receptors

Authors: Santosh Alluri，Seth M. Eisenberg，Laurel A. Grisanti，Miles Tanner，Nora D. Volkow，Sung Won Kim，Kun-Eek Kil

Journal: European Journal of Medicinal Chemistry

Doi: doi.org/10.1016/j.ejmech.2022.114764

Products & Services: ORF cDNA Clones/MolecularCloud

E2/E3‐independent ubiquitin‐like protein conjugation by Urm1 is directly coupled to cysteine persulfidation

Authors: Keerthiraju E Ravichandran , Lars Kaduhr , Bozena Skupien-Rabian , Ekaterina Shvetsova , Mikołaj Sokołowski , Ros Cisław Krutyhołowa ,Dominika Kwasna , Cindy Brachmann , Sean Lin , Sebastian Guzman Perez , Piotr Wilk , Manuel Kösters , Przemysław Grudnik , Urszula Jankowska , Sebastian A Leidel , Raffael Schaffrath , Sebastian Glatt

Journal: EMBO J

PubMed ID: 36102610

Doi: 10.15252/embj.2022111318

Products & Services: Gene Synthesis

Engineering a powerful green cell factory for robust photoautotrophic diterpenoid production

Authors: Alexander Einhaus , Jasmin Steube , Robert Ansgar Freudenberg , Jonas Barczyk , Thomas Baier , Olaf Kruse

Journal: Metab Eng

PubMed ID: 35717002

Doi: 10.1016/j.ymben.2022.06.002

Products & Services: Gene Synthesis

Gene Promotes Muscle Growth and Development in Meat Ducks

Authors: Tingting Zhou, Yijing Wu, Yulin Bi, Hao Bai, Yong Jiang, Guohong Chen, Guobin Chang, Zhixiu Wang

Journal: Genes (Basel)

PubMed ID: 36140742

Doi: 10.3390/genes13091574

Products & Services: DNA Sequencing

Chaperonin CCT5 binding with porcine parvovirus NS1 promotes the interaction of NS1 and COPƐ to facilitate viral replication

Authors: Qian Du, Xuezhi Zhang, Ning Xu, Mengyu Ma, Bicheng Miao, Yong Huang, Dewen Tong

Journal: Vet Microbiol

PubMed ID: 36126504

Doi: 10.1016/j.vetmic.2022.109574

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Near Infrared Emitting Semiconductor Polymer Dots for Bioimaging and Sensing

Authors: Connor Riahin, Kushani Mendis, Brandon Busick, Marcin Ptaszek, Mengran Yang, Gary Stacey, Amar Parvate, James E Evans, Jeremiah Traeger, Dehong Hu, Galya Orr, Zeev Rosenzweig

Journal: Sensors (Basel)

PubMed ID: 36236328

Doi: 10.3390/s22197218

Products & Services: Protein and Antibody Isolation

High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development

Authors: Shalev Gihaz, Peter Gareiss, Jae-Yeon Choi, Isaline Renard, Anasuya Chattopadhyay Pal, Yulia Surovsteva, Joy E Chiu, Jose Thekkiniath, Mark Plummer, William Hungerford, Micaela L Montgomery, Alanah Hosford, Emily M Adams, Jorge D Lightfoot, David Fox, Kayode K Ojo, Bart L Staker, Kevin Fuller, Choukri Ben Mamoun

Journal: Structure

PubMed ID: 36167065

Doi: 10.1016/j.str.2022.09.001

Products & Services: Plasmid DNA Preparation