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页码: 124/1027 每页显示数量

CRISPR/Cas9 Approach to Generate an Auxotrophic BCG Strain for Unmarked Expression of LTAK63 Adjuvant: A Tuberculosis Vaccine Candidate

Authors: Luana Moraes, Monalisa Martins Trentini, Dimitrios Fousteris, Silas Fernandes Eto, Ana Marisa Chudzinski-Tavassi, Luciana Cezar de Cerqueira Leite, Alex Issamu Kanno

Journal: Front Immunol

PubMed ID: 35432328

Doi: 10.3389/fimmu.2022.867195

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Multimodal evaluation of an interphotoreceptor retinoid-binding protein-induced mouse model of experimental autoimmune uveitis

Authors: Jee Myung Yang, KyungA Yun, Jehwi Jeon, Hae Young Yang, Bora Kim, Sunhong Jeong, Junyeop Lee, Wang-Yuhl Oh, Akiyoshi Uemura, Joon Seon Song, Pilhan Kim, Joo Yong Lee

Journal: Exp Mol Med

PubMed ID: 35264718

Doi: 10.1038/s12276-022-00733-z

Products & Services: Peptide Synthesis

The circular RNA circNlgnmediates doxorubicin-inducedcardiac remodeling and fibrosis

Authors: Jindong Xu, William W Du, Nan Wu, Feiya Li, Xiangmin Li, Yizhen Xie, Sheng Wang, Burton B Yang

Journal: Mol Ther Nucleic Acids

PubMed ID: 35402068

Doi: 10.1016/j.omtn.2022.03.007

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Determination of T Cell Responses in Thai Systemic Sclerosis Patients

Authors: Oranit Likhit, Worawit Louthrenoo, Sa-Nga Pattanakitsakul, Aroonroong Suttitheptumrong, Supot Hannongbua, Thanyada Rungrotmongkol, Hiroshi Noguchi, Fujio Takeuchi, Kobporn Boonnak

Journal: J Immunol Res

PubMed ID: 35310606

Doi: 10.1155/2022/5072154

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Structural and functional analysis of the human cone-rod homeobox transcription factor

Authors: Penelope-Marie B Clanor, Christine N Buchholz, Jonathan E Hayes, Michael A Friedman, Andrew M White, Ray A Enke, Christopher E Berndsen

Journal: Proteins

PubMed ID: 35255174

Doi: 10.1002/prot.26332

Products & Services: Mammalian Expression

Gestational Leucylation Suppresses Embryonic T-Box Transcription Factor 5 Signal and Causes Congenital Heart Disease

Authors: Xuan Zhang , Lian Liu , Wei-Cheng Chen , Feng Wang , Yi-Rong Cheng , Yi-Meng Liu , Yang-Fan Lai , Rui-Jia Zhang , Ya-Nan Qiao , Yi-Yuan Yuan , Yan Lin , Wei Xu , Jing Cao , Yong-Hao Gui , Jian-Yuan Zhao

Journal: Adv Sci (Weinh)

PubMed ID: 35320615

Doi: 10.1002/advs.202201034

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Milk Fat Globule Membrane Alleviates Short Bowel Syndrome-Associated Liver Injury in Rats Through Inhibiting Autophagy and NLRP3 Inflammasome Activation

Authors: Zhicai Yu , Shanshan Huang , Ying Li , Yang Niu , Honghao Chen , Jiang Wu

Journal: Front Nutr

PubMed ID: 35308293

Doi: 10.3389/fnut.2022.758762

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A novel epigenetic marker, Ten-eleven translocation family member 2 (TET2), is identified in the intractable epileptic brain and regulates ATP binding cassette subfamily B member 1 (ABCB1) in the blood-brain barrier

Authors: Fan-Cheng Kong, Li-Qin Lang, Jie Hu, Xia-Ling Zhang, Ming-Kang Zhong, Chun-Lai Ma

Journal: Bioengineered

PubMed ID: 35235761

Doi: 10.1080/21655979.2022.2045838

Products & Services: Proteins, Expression, Isolation and Analysis

The N-terminal helices of amphiphysin and endophilin have different capabilities of membrane remodeling

Authors: Chinta M Aryal, Nhat Nguyen Bui, Likai Song, Jianjun Pan

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 35247332

Doi: 10.1016/j.bbamem.2022.183907

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SARS-CoV-2's high rate of genetic mutation under immune selective pressure: from oropharyngeal B117 to intrapulmonary B1533 in a post-vaccine patient

Authors: Nicolò Musso, Jessica Giuseppina Maugeri, Dafne Bongiorno, Stefano Stracquadanio, Giovanni Bartoloni, Stefania Stefani, Emanuela Daniela Di Stefano

Journal: Int J Infect Dis

PubMed ID: 35247550

Doi: 10.1016/j.ijid.2022.02.044

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Enantioselectivity and key residue of Herbaspirillum huttiense monooxygenase in asymmetric epoxidation of styrenes

Authors: Shuang Dong, Donglin Fan, Qian Liu, Yinyin Meng, Xinyu Liu, Sen Yang, Hui Lin, Na Li, Hongge Chen

Journal: Appl Microbiol Biotechnol

PubMed ID: 35230494

Doi: 10.1007/s00253-022-11843-z

Products & Services: Proteins, Expression, Isolation and Analysis

Cryo-EM structure of a SARS-CoV-2 omicron spike protein ectodomain

Authors: Gang Ye, Bin Liu, Fang Li

Journal: Nat Commun

PubMed ID: 35241675

Doi: 10.1038/s41467-022-28882-9

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mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice

Authors: Zekun Mu, Kevin Wiehe, Kevin O Saunders, Rory Henderson, Derek W Cain, Robert Parks, Diana Martik, Katayoun Mansouri, Robert J Edwards, Amanda Newman, Xiaozhi Lu, Shi-Mao Xia, Amanda Eaton, Mattia Bonsignori, David Montefiori, Qifeng Han, Sravani Venkatayogi, Tyler Evangelous, Yunfei Wang, Wes Rountree, Bette Korber, Kshitij Wagh, Ying Tam, Christopher Barbosa, S Munir Alam, Wilton B Williams, Ming Tian, Frederick W Alt, Norbert Pardi, Drew Weissman, Barton F Haynes

Journal: Cell Rep

PubMed ID: 35294883

Doi: 10.1016/j.celrep.2022.110514

Products & Services: Gene Synthesis

Antibody-Peptide Epitope Conjugates for Personalized Cancer Therapy

Authors: Songfa Zhang, Chuan Yan, David G Millar, Qiqi Yang, James M Heather, Adam Langenbucher, Laura T Morton, Sean Sepulveda, Eric Alpert, Lauren R Whelton, Dominique T Zarrella, Mei Guo, Eleanor Minogue, Michael S Lawrence, Bo R Rueda, David R Spriggs, Weiguo Lu, David M Langenau, Mark Cobbold

Journal: Cancer Res

PubMed ID: 34965933

Doi: 10.1158/0008-5472.CAN-21-2200

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Efficient C-to-G Base Editing with Improved Target Compatibility Using Engineered Deaminase-nCas9 Fusions

Authors: Siyu Chen, Zhiquan Liu, Liangxue Lai, Zhanjun Li

Journal: CRISPR J

PubMed ID: 35238619

Doi: 10.1089/crispr.2021.0124

Products & Services: GenParts™ DNA Fragments

A rulebook for peptide control of legume-microbe endosymbioses

Authors: Sonali Roy, Lena Maria Müller

Journal: Trends Plant Sci

PubMed ID: 35246381

Doi: 10.1016/j.tplants.2022.02.002

Products & Services: Peptide Synthesis

Understanding desaturation/hydroxylation activity of castor stearoyl Δ9-Desaturase through rational mutagenesis

Authors: Michal Tupec , Martin Culka , Aleš Machara , Stanislav Machácˇek , Daniel Bím , Aleš Svatoš , Lubomír Rulíšek , Iva Pichová

Journal: Elsevier B.V.

Doi: 10.1016/j.csbj.2022.03.010

Products & Services: Gene Synthesis

Changes in genotoxic stress response, ribogenesis and PAP (3'-phosphoadenosine 5'-phosphate) levels are associated with loss of desiccation tolerance in overprimed Medicago truncatula seeds

Authors: Andrea Pagano, Lorena Zannino, Paola Pagano, Enrico Doria, Daniele Dondi, Anca Macovei, Marco Biggiogera, Susana de Sousa Araújo, Alma Balestrazzi

Journal: Plant Cell Environ

PubMed ID: 35188276

Doi: 10.1111/pce.14295

Products & Services: Custom DNA/RNA Oligos

Expression of a Cytochrome P450 Gene from Bermuda Grass in Soybean Confers Tolerance to Multiple Herbicides

Authors: Ting Zheng, Xiaoxing Yu, Yongzheng Sun, Qing Zhang, Xianwen Zhang, Mengzhen Tang, Chaoyang Lin, Zhicheng Shen

Journal: Plants (Basel)

PubMed ID: 35406929

Doi: 10.3390/plants11070949

Products & Services: Monoclonal Antibody Services

Downregulation of m A writer complex member METTL14 in bladder urothelial carcinoma suppresses tumor aggressiveness

Authors: Catarina Guimarães-Teixeira, João Lobo, Vera Miranda-Gonçalves, Daniela Barros-Silva, Cláudia Martins-Lima, Sara Monteiro-Reis, José Pedro Sequeira, Isa Carneiro, Margareta P Correia, Rui Henrique, Carmen Jerónimo

Journal: Mol Oncol

PubMed ID: 35048498

Doi: 10.1002/1878-0261.13181

Products & Services: Plasmid DNA Preparation

TNF-α stimulation enhances the neuroprotective effects of gingival MSCs derived exosomes in retinal ischemia-reperfusion injury via the MEG3/miR-21a-5p axis

Authors: Ziyu Yu, Yuwen Wen, Nan Jiang, Zhidong Li, Jieying Guan, Yingying Zhang, Caibing Deng, Ling Zhao, Song Guo Zheng, Yingting Zhu, Wenru Su, Yehong Zhuo

Journal: Biomaterials

PubMed ID: 35378413

Doi: 10.1016/j.biomaterials.2022.121484

Products & Services: Proteins, Expression, Isolation and Analysis

Robust Pharmacology of Tmod, a Synthetic Dual-Signal Integrator for Cancer Cell Therapy

Authors: Diane Manry, Kristian Bolanos, Breanna DiAndreth, Jee-Young Mock, Alexander Kamb

Journal: Front Immunol

PubMed ID: 35359952

Doi: 10.3389/fimmu.2022.826747

Products & Services: Peptide Synthesis

Current Status and Future Perspectives on MRNA Drug Manufacturing

Authors: Cameron Webb, Shell Ip, Nuthan V Bathula, Petya Popova, Shekinah K V Soriano, Han Han Ly, Burcu Eryilmaz, Viet Anh Nguyen Huu, Richard Broadhead, Martin Rabel, Ian Villamagna, Suraj Abraham, Vahid Raeesi, Anitha Thomas, Samuel Clarke, Euan C Ramsay, Yvonne Perrie, Anna K Blakney

Journal: Mol Pharm

PubMed ID: 35238565

Doi: 10.1021/acs.molpharmaceut.2c00010

Products & Services: Gene Synthesis

Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention

Authors: Yan-Ruide Li, Zachary Spencer Dunn, Gustavo Garcia, Camille Carmona, Yang Zhou, Derek Lee, Jiaji Yu, Jie Huang, Jocelyn T Kim, Vaithilingaraja Arumugaswami, Pin Wang, Lili Yang

Journal: Stem Cell Res Ther

PubMed ID: 35313965

Doi: 10.1186/s13287-022-02787-2

Products & Services: GenParts™ DNA Fragments

SARS-CoV-2 mRNA vaccine induced higher antibody affinity and IgG titers against variants of concern in post-partum vs non-post-partum women

Authors: Youri Lee, Gabrielle Grubbs, Sabrina C Ramelli, Andrea R Levine, Allison Bathula, Kapil Saharia, Madeleine Purcell, Shreya Singireddy, Colleen L Dugan, Lindsey Kirchoff, Allison Lankford, Sarah Cipriano, Ryan A Curto, Jocelyn Wu, Katherine Raja, Emily Kelley, Daniel Herr, Kevin M Vannella, Supriya Ravichandran, Juanjie Tang, Anthony Harris, Mohammad Sajadi, Daniel S Chertow, Alison Grazioli, Surender Khurana

Journal: EBioMedicine

PubMed ID: 35301181

Doi: 10.1016/j.ebiom.2022.103940

Products & Services: Catalog Antibody

Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress

Authors: Aijun Liu, Yonglin Zhang, Shucan Xun, Guangzhi Zhou, Li Lin, Yong Mei

Journal: Peptides

PubMed ID: 35304156

Doi: 10.1016/j.peptides.2022.170786

Products & Services: Custom DNA/RNA Oligos

The receptor-like cytosolic kinase RIPK activates NADP-malic enzyme 2 to generate NADPH for fueling ROS production

Authors: Binyan Wu, Ping Li, Xiufang Hong, Cuihong Xu, Ran Wang, Yan Liang

Journal: Mol Plant

PubMed ID: 35276409

Doi: 10.1016/j.molp.2022.03.003

Products & Services: Gene Synthesis

Cytoplasmic domain and enzymatic activity of ACE2 are not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cells

Authors: Hang Yang, Huijun Yuan, Xiaohui Zhao, Meng Xun, Shangrui Guo, Nan Wang, Bing Liu, Hongliang Wang

Journal: Virol Sin

PubMed ID: 35272059

Doi: 10.1016/j.virs.2022.03.003

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Aquaporin OsPIP2;2 links the H2O2 signal and a membrane-anchored transcription factor to promote plant defense

Authors: Mou Zhang, Haotian Shi, Ningning Li, Nana Wei, Yan Tian, Jinfeng Peng, Xiaochen Chen, Liyuan Zhang, Meixiang Zhang, Hansong Dong

Journal: Plant Physiol

PubMed ID: 34958388

Doi: 10.1093/plphys/kiab604

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Genetically engineered pH-responsive silk sericin nanospheres with efficient therapeutic effect on ulcerative colitis

Authors: Sheng Xu, Qianqian Yang, Riyuan Wang, Chi Tian, Yanting Ji, Huanhuan Tan, Ping Zhao, David L Kaplan, Feng Wang, Qingyou Xia

Journal: Acta Biomater

PubMed ID: 35288310

Doi: 10.1016/j.actbio.2022.03.012

Products & Services: Proteins, Expression, Isolation and Analysis

HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people

Authors: Jennifer R Habel, Andrea T Nguyen, Louise C Rowntree, Christopher Szeto, Nicole A Mifsud, E Bridie Clemens, Liyen Loh, Weisan Chen, Steve Rockman, Jane Nelson, Jane Davies, Adrian Miller, Steven Y C Tong, Jamie Rossjohn, Stephanie Gras, Anthony W Purcell, Luca Hensen, Katherine Kedzierska, Patricia T Illing

Journal: PLoS Pathog

PubMed ID: 35255101

Doi: 10.1371/journal.ppat.1010337

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Physical Interaction between Cyclin-Dependent Kinase 5 (CDK5) and Clock Factors Affects the Circadian Rhythmicity in Peripheral Oscillators

Authors: Jürgen A Ripperger, Rohit Chavan, Urs Albrecht, Andrea Brenna

Journal: Clocks Sleep

PubMed ID: 35323171

Doi: 10.3390/clockssleep4010017

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RNA chain length and stoichiometry govern surface tension and stability of protein-RNA condensates

Authors: Rabia Laghmach, Ibraheem Alshareedah, Matthew Pham, Muralikrishna Raju, Priya R Banerjee, Davit A Potoyan

Journal: iScience

PubMed ID: 35378855

Doi: 10.1016/j.isci.2022.104105

Products & Services: Proteins, Expression, Isolation and Analysis

Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue

Authors: Federico Cerullo, Sebastian Filbeck, Pratik Rajendra Patil, Hao-Chih Hung, Haifei Xu, Julia Vornberger, Florian W Hofer, Jaro Schmitt, Guenter Kramer, Bernd Bukau, Kay Hofmann, Stefan Pfeffer, Claudio A P Joazeiro

Journal: Nature

PubMed ID: 35264791

Doi: 10.1038/s41586-022-04487-6

Products & Services: Proteins, Expression, Isolation and Analysis

Peptide-based simple detection of SARS-CoV-2 with electrochemical readout

Authors: Dayana Soto, Jahir Orozco

Journal: Anal Chim Acta

PubMed ID: 35414399

Doi: 10.1016/j.aca.2022.339739

Products & Services: Recombinant Antibody Expression

Combined Subcutaneous-Intranasal Immunization With Epitope-Based Antigens Elicits Binding and Neutralizing Antibody Responses in Serum and Mucosae Against PRRSV-2 and SARS-CoV-2

Authors: Mario Fragoso-Saavedra, Carmen Ramírez-Estudillo, Diana L Peláez-González, Jorge O Ramos-Flores, Gustavo Torres-Franco, Leandro Núñez-Muñoz, Gabriel Marcelino-Pérez, María G Segura-Covarrubias, Rogelio González-González, Roberto Ruiz-Medrano, Beatriz Xoconostle-Cázares, Amanda Gayosso-Vázquez, Silvia Reyes-Maya, Vianey Ramírez-Andoney, Rogelio A Alonso-Morales, Marco A Vega-López

Journal: Front Immunol

PubMed ID: 35432364

Doi: 10.3389/fimmu.2022.848054

Protein chain collapse modulation and folding stimulation by GroEL-ES

Authors: Mohsin M Naqvi, Mario J Avellaneda, Andrew Roth, Eline J Koers, Antoine Roland, Vanda Sunderlikova, Günter Kramer, Hays S Rye, Sander J Tans

Journal: Sci Adv

PubMed ID: 35245117

Doi: 10.1126/sciadv.abl6293

Products & Services: Recombinant Proteins

CTNNBL1 restricts HIV-1 replication by suppressing viral DNA integration into the cell genome

Authors: Guoxin Liang, Yang He, Li Zhao, Jiayue Ouyang, Wenqing Geng, Xiaowei Zhang, Xiaoxu Han, Yongjun Jiang, Haibo Ding, Ying Xiong, Jinxiu Dong, Mei Liu, Hong Shang

Journal: Cell Rep

PubMed ID: 35294870

Doi: 10.1016/j.celrep.2022.110533

Products & Services: Plasmid DNA Preparation

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

Authors: Rachid Essalmani, Jaspreet Jain, Delia Susan-Resiga, Ursula Andréo, Alexandra Evagelidis, Rabeb Mouna Derbali, David N Huynh, Frédéric Dallaire, Mélanie Laporte, Adrien Delpal, Priscila Sutto-Ortiz, Bruno Coutard, Claudine Mapa, Keith Wilcoxen, Etienne Decroly, Tram Nq Pham, Éric A Cohen, Nabil G Seidah

Journal: J Virol

PubMed ID: 35343766

Doi: 10.1128/jvi.00128-22

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CD4+ T cells from COVID-19 mRNA vaccine recipients recognize a conserved epitope present in diverse coronaviruses

Authors: Bezawit A Woldemeskel, Arbor G Dykema, Caroline C Garliss, Saphira Cherfils, Kellie N Smith, Joel N Blankson

Journal: J Clin Invest

PubMed ID: 35061630

Doi: 10.1172/JCI156083

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KIR3DL05 and KIR3DS02 Recognition of a Nonclassical MHC Class I Molecule in the Rhesus Macaque Implicated in Pregnancy Success

Authors: Rachel E Nicholas, Kjell Sandstrom, Jennifer L Anderson, Willow R Smith, Molly Wetzel, Priyankana Banerjee, Sanath Kumar Janaka, David T Evans

Journal: Front Immunol

PubMed ID: 35401580

Doi: 10.3389/fimmu.2022.841136

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ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma

Authors: Ji-Ye Kim, Entaz Bahar, Jung-Yun Lee, Sunhee Chang, Se Hoon Kim, Eun Young Park, Sung-Im Do, Hyonok Yoon, Hyun-Soo Kim

Journal: Cell Death Dis

PubMed ID: 35293383

Doi: 10.1038/s41419-022-04568-4

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A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis

Authors: Yun Ji Park, Richard J Jodts, Jeffrey W Slater, Reyvin M Reyes, Valerie J Winton, Rana A Montaser, Paul M Thomas, William B Dowdle, Anahi Ruiz, Neil L Kelleher, J Martin Bollinger, Carsten Krebs, Brian M Hoffman, Amy C Rosenzweig

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35320042

Doi: 10.1073/pnas.2123566119

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AcrIF5 specifically targets DNA-bound CRISPR-Cas surveillance complex for inhibition

Authors: Yongchao Xie, Laixing Zhang, Zhengyu Gao, Peipei Yin, Hao Wang, Hang Li, Zeliang Chen, Yi Zhang, Maojun Yang, Yue Feng

Journal: Nat Chem Biol

PubMed ID: 35301482

Doi: 10.1038/s41589-022-00995-8

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RACK1 Associates with RNA-Binding Proteins Vigilin and SERBP1 to Facilitate Dengue Virus Replication

Authors: Alexis Brugier, Mohamed Lamine Hafirrassou, Marie Pourcelot, Morgane Baldaccini, Vasiliya Kril, Laurine Couture, Beate M Kümmerer, Sarah Gallois-Montbrun, Lucie Bonnet-Madin, Pierre-Olivier Vidalain, Constance Delaugerre, Sébastien Pfeffer, Laurent Meertens, Ali Amara

Journal: J Virol

PubMed ID: 35266803

Doi: 10.1128/jvi.01962-21

Products & Services: Mammalian Expression

OvoA from ovothiol biosynthesis is a bifunction enzyme: thiol oxygenase and sulfoxide synthase activities

Authors: Ronghai Cheng, Andrew C Weitz, Jared Paris, Yijie Tang, Jingyu Zhang, Heng Song, Nathchar Naowarojna, Kelin Li, Lu Qiao, Juan Lopez, Mark W Grinstaff, Lixin Zhang, Yisong Guo, Sean Elliott, Pinghua Liu

Journal: Chem Sci

PubMed ID: 35432880

Doi: 10.1039/d1sc05479a

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miR-2055 regulates lipid metabolism via fatty acid synthase expression

Authors: Yang Cheng, Tengfei Lu, Junliang Guo, Zhe Lin, Qiao Jin, Xiaoming Zhang, Zhen Zou

Journal: Open Biol

PubMed ID: 35232249

Doi: 10.1098/rsob.210307

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Role of polyphenols in combating Type 2 Diabetes and insulin resistance

Authors: Moyad Shahwan, Fahad Alhumaydhi, Ghulam Md Ashraf, Prince M Z Hasan, Anas Shamsi

Journal: Int J Biol Macromol

PubMed ID: 35247420

Doi: 10.1016/j.ijbiomac.2022.03.004

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Role of polyphenols in combating Type 2 Diabetes and insulin resistance

Authors: Moyad Shahwan, Fahad Alhumaydhi, Ghulam Md Ashraf, Prince M Z Hasan, Anas Shamsi

Journal: Int J Biol Macromol

PubMed ID: 35247420

Doi: 10.1016/j.ijbiomac.2022.03.004

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Therapeutic Effect of Extracellular Vesicles Derived from HIF Prolyl Hydroxylase Domain Enzyme Inhibitor-Treated Cells on Renal Ischemia/Reperfusion Injury

Authors: Zhao-Ying Ding, Tao-Tao Tang, Zuo-Lin Li, Jing-Yuan Cao, Lin-Li Lv, Yi Wen, Bin Wang, Bi-Cheng Liu

Journal: Kidney Dis (Basel)

PubMed ID: 35702708

Doi: 10.1159/000522584

Products & Services: Proteins, Expression, Isolation and Analysis

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