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The Therapeutic Effects of a PEDF-Derived Short Peptide on Murine Experimental Dry Eye Involves Suppression of MMP-9 and Inflammation

Authors: Tsung-Chuan Ho, Nai-Wen Fan, Shu-I Yeh, Show-Li Chen, Yeou-Ping Tsao

Journal: Transl Vis Sci Technol

PubMed ID: 36201200

Doi: 10.1167/tvst.11.10.12

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Single-cell RNA sequencing analysis of shrimp immune cells identifies macrophage-like phagocytes

Authors: Peng Yang , Yaohui Chen , Zhiqi Huang , Huidan Xia , Ling Cheng , Hao Wu , Yueling Zhang , Fan Wang

Journal: Elife

PubMed ID: 36200862

Doi: 10.7554/eLife.80127

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Intracellular infection by symbiotic bacteria requires the mitotic kinase AURORA1

Authors: Jin-Peng Gao , Suyu Jiang , Yangyang Su , Ping Xu , Junjie Wang , Wenjie Liang , Cheng-Wu Liu , Jeremy D Murray

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36252014

Doi: doi.org/10.1073/pnas.2202606119

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Structural basis for product specificities of MLL family methyltransferases

Authors: Yanjing Li , Lijie Zhao , Yuebin Zhang , Ping Wu , Ying Xu , Jun Mencius , Yongxin Zheng , Xiaoman Wang , Wancheng Xu , Naizhe Huang , Xianwen Ye , Ming Lei , Pan Shi , Changlin Tian , Chao Peng , Guohui Li , Zhijun Liu , Shu Quan , Yong Chen

Journal: Mol Cell

PubMed ID: 36108631

Doi: 10.1016/j.molcel.2022.08.022

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Human melanocortin-2 receptor: Identifying a role for residues in the TM4, EC2, and TM5 domains in activation and trafficking as a result of co-expression with the accessory protein, Mrap1 in Chinese Hamster Ovary Cells.

Authors: Perry V Davis , Ciaran A Shaughnessy , Robert M Dores

Journal: Biomolecules

PubMed ID: 36291631

Doi: 10.3390/biom12101422

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Labeling Ebola Virus with a Self-Splicing Fluorescent Reporter

Authors: Baylee Heiden , Elke Mühlberger , Christopher W Lennon , Adam J Hume

Journal: Microorganisms

PubMed ID: 36363701

Doi: 10.3390/microorganisms10112110

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Advanced pathway engineering for phototrophic putrescine production

Authors: Robert A Freudenberg , Luisa Wittemeier , Alexander Einhaus , Thomas Baier , Olaf Kruse

Journal: Plant Biotechnol J

PubMed ID: 35748533

Doi: 10.1111/pbi.13879

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Crystal structure of an L-type lectin domain from archaea

Authors: Farha Khan, Kaza Suguna

Journal: Proteins

PubMed ID: 36301308

Doi: 10.1002/prot.26440

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Authors: Eyby Leon, Claris Nde, Randall S Ray, Diego Preciado, Irene E Zohn

Journal: Am J Med Genet A

PubMed ID: 36263470

Doi: 10.1002/ajmg.a.62991

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Correction to: Selection of DNA aptamer and its application as an electrical biosensor for Zika virus detection in human serum

Authors: Goeun Park, Myoungro Lee, Jiatong Kang, Chulwhan Park, Junhong Min, Taek Lee

Journal: Nano Converg

PubMed ID: 36315359

Doi: 10.1186/s40580-022-00340-8

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Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance

Authors: Jaël S Copier , Marianne Bootsma , Chai A Ng , Arthur A M Wilde , Robin A Bertels , Hennie Bikker , Imke Christiaans , Saskia N van der Crabben , Janna A Hol , Tamara T Koopmann , Jeroen Knijnenburg , Aafke A J Lommerse , Jasper J van der Smagt , Connie R Bezzina , Jamie I Vandenberg , Arie O Verkerk , Daniela Q C M Barge-Schaapveld , Elisabeth M Lodder

Journal: Hum Mol Genet

PubMed ID: 36269083

Doi: 10.1093/hmg/ddac261

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Metabolomic analysis of rapeseed priming with H2O2 in response to germination under chilling stress

Authors: Zhiwei Gu, Duan Wang, Qingtao Gong, Juan You, Qingji Ren, Haimei An, Yongyin Zhou, Haidong Jiang

Journal: Plant Growth Regulation

Doi: 10.1007/s10725-022-00918-6

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Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair

Authors: Oguz Bolgi, Maria Silva-Garcia, Breyan Ross, Esther Pilla, Vijayalakshmi Kari, Markus Killisch, Melanie Spitzner, Nadine Stark, Christof Lenz, Konstantin Weiss, Laura Donzelli, Mark D Gorrell, Marian Grade, Jan Riemer, Henning Urlaub, Matthias Dobbelstein, Robert Huber, Ruth Geiss-Friedlander

Journal: EMBO Reports

Doi: 10.15252/embr.202154136

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Available online 28 June 2022 0925-4005/© 2022 Elsevier B.V. All rights reserved. A universal CRISPR/Cas12a-mediated AuNPs aggregation-based surface-enhanced Raman scattering (CRISPR/Cas-SERS) platform for virus gene detection

Authors: Ailing Su ， Yuan Liu , Xiumian Cao , Weiqing Xu , Chongyang Liang , Shuping Xu

Journal: Sensors and Actuators B: Chemical

Doi: 10.1016/j.snb.2022.132295

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A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin

Authors: Qiyao Chai , Shanshan Yu, Yanzhao Zhong , Zhe Lu , Changgen Qiu, Yang Yu , Xinwen Zhang , Yong Zhang, Zehui Lei, Lihua Qiang, Bing-Xi Li, Yu Pang, Xiao-Bo Qiu, Jing Wang , Cui Hua Liu

Journal: Science .

PubMed ID: 36227980

Doi: 10.1126/science.abq0132

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Deciphering the Immunogenicity of Monkeypox Proteins for Designing the Potential mRNA Vaccine

Authors: Mohibullah Shah; Samavia Jaan; Muhammad Shehroz; Asifa Sarfraz; Khamna Asad; Tehreem Ul Wara; Aqal Zaman; Riaz Ullah; Essam A. Ali; Umar Nishan; Suvash Chandra Ojha

Journal: ACS Omega

PubMed ID: 38024731

Doi: 10.1021/acsomega.3c07866

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Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein

Authors: Xiaodong Luan, Xinming Li, Yufan Li, Gengchen Su, Wanchao Yin, Yi Jiang, Ning Xu, Feng Wang, Wang Cheng, Ye Jin, Leike Zhang, H. Eric Xu, Yi Xue, Shuyang Zhang

Journal: Science Bulletin

Doi: 10.1016/j.scib.2022.10.021

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NAC Transcription Factor Improved Drought Stress Tolerance in Soybean

Authors: Chengfeng Yang, Yanzhong Huang, Peiyun Lv, Augustine Antwi-Boasiako, Naheeda Begum, Tuanjie Zhao, Jinming Zhao

Journal: Int J Mol Sci

PubMed ID: 36233329

Doi: 10.3390/ijms231912029

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Rescue of the first alphanucleorhabdovirus entirely from cloned complementary DNA: An efficient vector for systemic expression of foreign genes in maize and insect vectors

Authors: Surapathrudu Kanakala, César A D Xavier, Kathleen M Martin, Hong Hanh Tran, Margaret G Redinbaugh, Anna E Whitfield

Journal: Mol Plant Pathol

PubMed ID: 36239302

Doi: 10.1111/mpp.13273

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Oxidative Stress Amelioration of Novel Peptides Extracted from Enzymatic Hydrolysates of Chinese Pecan Cake

Authors: Jiaojiao Zhang, Shaozhen Wu, Qingqing Wang, Qinjie Yuan, Yane Li, Patricia Reboredo-Rodríguez, Alfonso Varela-López, Zhiping He, Fenghua Wu, Hao Hu, Xingquan Liu

Journal: Int J Mol Sci

PubMed ID: 36292968

Doi: 10.3390/ijms232012086

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Ubiquitin proteolysis of a CDK-related kinase regulates titan cell formation and virulence in the fungal pathogen Cryptococcus neoformans

Authors: Chengjun Cao, Keyi Wang, Yina Wang, Tong-Bao Liu, Amariliz Rivera, Chaoyang Xue

Journal: Nat Commun

PubMed ID: 36302775

Doi: 10.1038/s41467-022-34151-6

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CP12 fine-tunes the Calvin-Benson cycle and carbohydrate metabolism in cyanobacteria

Authors: Stefan Lucius, Marius Theune, Stéphanie Arrivault, Sarah Hildebrandt, Conrad W Mullineaux, Kirstin Gutekunst, Martin Hagemann

Journal: Front Plant Sci

PubMed ID: 36330266

Doi: 10.3389/fpls.2022.1028794

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Ablation of CD8 T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA1, BA2 and BA3

Authors: Srividhya Swaminathan, Katie E Lineburg, Archana Panikkar, Jyothy Raju, Lawton D Murdolo, Christopher Szeto, Pauline Crooks, Laetitia Le Texier, Sweera Rehan, Michael J Dewar-Oldis, Peter J Barnard, George R Ambalathingal, Michelle A Neller, Kirsty R Short, Stephanie Gras, Rajiv Khanna, Corey Smith

Journal: Nat Commun

PubMed ID: 36302758

Doi: 10.1038/s41467-022-34180-1

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The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

Authors: Lavanya Moparthi, Viktor Sinica, Vamsi K Moparthi, Mohamed Kreir, Thibaut Vignane, Milos R Filipovic, Viktorie Vlachova, Peter M Zygmunt

Journal: Nat Commun

PubMed ID: 36253390

Doi: 10.1038/s41467-022-33876-8

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Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology

Authors: Anika Heinze, Cara Schuldt, Sharof Khudayberdiev, Bas van Bommel, Daniela Hacker, Toni G Schulz, Ramona Stringhi, Elena Marcello, Marina Mikhaylova, Marco B Rust

Journal: Cell Mol Life Sci

PubMed ID: 36264429

Doi: 10.1007/s00018-022-04593-8

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The seroprevalence of neutralizing antibodies against the adeno-associated virus capsids in Japanese hemophiliacs

Authors: Yuji Kashiwakura, Nemekhbayar Baatartsogt, Shoji Yamazaki, Azusa Nagao, Kagehiro Amano, Nobuaki Suzuki, Tadashi Matsushita, Akihiro Sawada, Satoshi Higasa, Naoya Yamasaki, Teruhisa Fujii, Taemi Ogura, Hideyuki Takedani, Masashi Taki, Takeshi Matsumoto, Jun Yamanouchi, Michio Sakai, Masako Nishikawa, Yutaka Yatomi, Koji Yada, Keiji Nogami, Ryota Watano, Takafumi Hiramoto, Morisada Hayakawa, Nobuhiko Kamoshita, Akihiro Kume, Hiroaki Mizukami, Shizukiyo Ishikawa, Yoichi Sakata, Tsukasa Ohmori

Journal: Mol Ther Methods Clin Dev

PubMed ID: 36381300

Doi: 10.1016/j.omtm.2022.10.014

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Development of a Factor VII Activating Protease (FSAP) generation assay and its application in studying FSAP in venous thrombosis

Authors: Michael Etscheid, Kay-Martin Hanschmann, Per Morten Sandset, Sandip M Kanse

Journal: Thromb Res

PubMed ID: 36265411

Doi: 10.1016/j.thromres.2022.09.027

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Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif

Authors: Wenwen Ru, Tomoyuki Koga, Xiaoyang Wang, Qiong Guo, Micah D Gearhart, Shidong Zhao, Mark Murphy, Hiroko Kawakami, Dylan Corcoran, Jiahai Zhang, Zhongliang Zhu, Xuebiao Yao, Yasuhiko Kawakami, Chao Xu

Journal: J Biol Chem

PubMed ID: 36257403

Doi: 10.1016/j.jbc.2022.102607

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Tannin Reduces the Incidence of Polyspermic Penetration in Porcine Oocytes

Authors: Jing-Tao Sun, Jia-Hui Liu, Xi-Qing Jiang, Xin Luo, Jin-Dong Yuan, Qi Zhang, Xin-Yue Qi, Sanghoon Lee, Zhong-Hua Liu, Jun-Xue Jin

Journal: Antioxidants (Basel)

PubMed ID: 36290750

Doi: 10.3390/antiox11102027

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Immunization with CRT-Induced Protective Immunity against Infection in BALB/c Mice

Authors: Lujuan Chen, Zhe Cheng, Siqi Xian, Bin Zhan, Zhijian Xu, Yan Yan, Jianfang Chen, Yanhai Wang, Limei Zhao

Journal: Trop Med Infect Dis

PubMed ID: 36288020

Doi: 10.3390/tropicalmed7100279

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Genetic variation in gene linked to predisposition of T2DM: A case control study

Authors: Archna Bhargave, Kiran Devi, Imteyaz Ahmad, Anita Yadav, Ranjan Gupta

Journal: J Diabetes Metab Disord

PubMed ID: 36249912

Doi: 10.1007/s40200-022-01131-y

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Molecular cloning and characterization of a novel bifunctional cellobiohydrolase/β-xylosidase from a metagenomic library of mangrove soil

Authors: Yi-De Liu, Ge Yuan, Yu-Ting An, Zi-Ran Zhu, Gang Li

Journal: Enzyme Microb Technol

PubMed ID: 36265247

Doi: 10.1016/j.enzmictec.2022.110141

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Efficacy and Safety of a Brain-Penetrant Biologic TNF-α Inhibitor in Aged APP/PS1 Mice

Authors: Weijun Ou, Yuu Ohno, Joshua Yang, Devaraj V Chandrashekar, Tamara Abdullah, Jiahong Sun, Riley Murphy, Chuli Roules, Nataraj Jagadeesan, David H Cribbs, Rachita K Sumbria

Journal: Pharmaceutics

PubMed ID: 36297637

Doi: 10.3390/pharmaceutics14102200

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Phytoremediation of isoproturon-contaminated sites by transgenic soybean

Authors: Xiangkun Kong, Na Lv, Songmeng Liu, Hui Xu, Junwei Huang, Xiangting Xie, Qing Tao, Baozhan Wang, Rong Ji, Qun Zhang, Jiandong Jiang

Journal: Plant Biotechnol J

PubMed ID: 36278914

Doi: 10.1111/pbi.13951

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Supramolecular Assembly and Small-Molecule Binding by Protein-Engineered Coiled-Coil Fibers

Authors: Dustin Britton, Julia Monkovic, Sihan Jia, Chengliang Liu, Farbod Mahmoudinobar, Michael Meleties, P Douglas Renfrew, Richard Bonneau, Jin Kim Montclare

Journal: Biomacromolecules

PubMed ID: 36227640

Doi: 10.1021/acs.biomac.2c01031

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Intrinsically disordered protein regions are required for cell wall homeostasis in

Authors: Yannick R Brunet, Cameron Habib, Anna P Brogan, Lior Artzi, David Z Rudner

Journal: Genes Dev

PubMed ID: 36265902

Doi: 10.1101/gad.349895.122

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Crystal Structures of Epstein-Barr Virus Bcl-2 Homolog BHRF1 Bound to Bid and Puma BH3 Motif Peptides

Authors: Chathura D Suraweera, Mark G Hinds, Marc Kvansakul

Journal: Viruses

PubMed ID: 36298777

Doi: 10.3390/v14102222

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Greater Phosphorylation of AMPK and Multiple AMPK Substrates in the Skeletal Muscle of 24 Month-old Calorie Restricted Compared to Ad Libitum Fed Male Rats

Authors: Amy Zheng, Seong Eun Kwak, Jesper B Birk, Edward B Arias, Dominic Thorley, Jørgen F P Wojtaszewski, Gregory D Cartee

Journal: J Gerontol A Biol Sci Med Sci

PubMed ID: 36269629

Doi: 10.1093/gerona/glac218

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Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparum

Authors: Ajit Kumar Singh, Margaret Phillips, Saleh Alkrimi, Marco Tonelli, Samuel P Boyson, Kiera L Malone, Jay C Nix, Karen C Glass

Journal: Int J Biol Macromol

PubMed ID: 36328269

Doi: 10.1016/j.ijbiomac.2022.10.247

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Predicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry

Authors: Tom Dixon, Derek MacPherson, Barmak Mostofian, Taras Dauzhenka, Samuel Lotz, Dwight McGee, Sharon Shechter, Utsab R Shrestha, Rafal Wiewiora, Zachary A McDargh, Fen Pei, Rajat Pal, João V Ribeiro, Tanner Wilkerson, Vipin Sachdeva, Ning Gao, Shourya Jain, Samuel Sparks, Yunxing Li, Alexander Vinitsky, Xin Zhang, Asghar M Razavi, István Kolossváry, Jason Imbriglio, Artem Evdokimov, Louise Bergeron, Wenchang Zhou, Jagat Adhikari, Benjamin Ruprecht, Alex Dickson, Huafeng Xu, Woody Sherman, Jesus A Izaguirre

Journal: Nat Commun

PubMed ID: 36202813

Doi: 10.1038/s41467-022-33575-4

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G3BP/Rin-Binding Motifs Inserted into Flexible Regions of nsP2 Support RNA Replication of Chikungunya Virus

Authors: Sainan Wang, Andres Merits

Journal: J Virol

PubMed ID: 36226983

Doi: 10.1128/jvi.01278-22

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Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity

Authors: Sujith Rajan, Peter Hofer, Amanda Christiano, Matthew Stevenson, Louis Ragolia, Eugenia Villa-Cuesta, Susan K Fried, Raymond Lau, Collin Braithwaite, Rudolf Zechner, Gary J Schwartz, M Mahmood Hussain

Journal: Metabolism

PubMed ID: 36228741

Doi: 10.1016/j.metabol.2022.155331

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Development of CD163 receptor-based enzyme-linked immunosorbent assay for diagnosis of porcine reproductive and respiratory syndrome virus

Authors: Rajib Deb, Ajay Kumar Yadav, Gyanendra Singh Sengar, Joyshikh Sonowal, D Lalita, Seema Rani Pegu, Indra Singh, Ningthoukhongjam Linda, Pranab Jyoti Das, Satish Kumar, Prasanna Pal, Souvik Paul, Swaraj Rajkhowa, Vivek Kumar Gupta

Journal: 3 Biotech

PubMed ID: 36276438

Doi: 10.1007/s13205-022-03376-z

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LncRNA XIST from the bone marrow mesenchymal stem cell derived exosome promotes osteosarcoma growth and metastasis through miR-655/ACLY signal

Authors: Guanghui Zhu, Yu Xia, Ziyue Zhao, Aoyu Li, Hui Li, Tao Xiao

Journal: Cancer Cell Int

PubMed ID: 36309693

Doi: 10.1186/s12935-022-02746-0

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The PSI Domain of the MET Oncogene Encodes a Functional Disulfide Isomerase Essential for the Maturation of the Receptor Precursor

Authors: Dogus Murat Altintas, Simona Gallo, Cristina Basilico, Marina Cerqua, Alessio Bocedi, Annapia Vitacolonna, Orsola Botti, Elena Casanova, Ilaria Rancati, Chiara Milanese, Sara Notari, Giorgia Gambardella, Giorgio Ricci, Pier Giorgio Mastroberardino, Carla Boccaccio, Tiziana Crepaldi, Paolo Maria Comoglio

Journal: Int J Mol Sci

PubMed ID: 36293286

Doi: 10.3390/ijms232012427

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COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

Authors: Giorgia Benegiamo, Maroun Bou Sleiman, Martin Wohlwend, Sandra Rodríguez-López, Ludger J E Goeminne, Pirkka-Pekka Laurila, Marie Klevjer, Minna K Salonen, Jari Lahti, Pooja Jha, Sara Cogliati, José Antonio Enriquez, Ben M Brumpton, Anja Bye, Johan G Eriksson, Johan Auwerx

Journal: Nat Metab

PubMed ID: 36253618

Doi: 10.1038/s42255-022-00655-0

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Structural and molecular determinants of Candida glabrata metacaspase maturation and activation by calcium

Authors: Léa Conchou, Bastien Doumèche, Frédéric Galisson, Sébastien Violot, Chloé Dugelay, Eric Diesis, Adeline Page, Anne-Lise Bienvenu, Stéphane Picot, Nushin Aghajari, Lionel Ballut

Journal: Commun Biol

PubMed ID: 36316540

Doi: 10.1038/s42003-022-04091-4

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APC/CCdc20-mediated degradation of Clb4 prompts astral microtubule stabilization at anaphase onset

Authors: Federico Zucca, Clara Visintin, Jiaming Li, Steven P Gygi, Rosella Visintin

Journal: J Cell Biol

PubMed ID: 36269172

Doi: 10.1083/jcb.202203089

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EP-Pred: A Machine Learning Tool for Bioprospecting Promiscuous Ester Hydrolases

Authors: Ruite Xiang, Laura Fernandez-Lopez, Ana Robles-Martín, Manuel Ferrer, Victor Guallar

Journal: Biomolecules

PubMed ID: 36291739

Doi: 10.3390/biom12101529

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Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack

Authors: Shuang Yang, Giorgos Hiotis, Yi Wang, Junjian Chen, Jia-Huai Wang, Mikyung Kim, Ellis L Reinherz, Thomas Walz

Journal: Nat Commun

PubMed ID: 36302771

Doi: 10.1038/s41467-022-34008-y

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