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Single-cell RNA sequencing analysis of shrimp immune cells identifies macrophage-like phagocytes

Authors: Peng Yang , Yaohui Chen , Zhiqi Huang , Huidan Xia , Ling Cheng , Hao Wu , Yueling Zhang , Fan Wang

Journal: Elife

PubMed ID: 36200862

Doi: 10.7554/eLife.80127

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Intracellular infection by symbiotic bacteria requires the mitotic kinase AURORA1

Authors: Jin-Peng Gao , Suyu Jiang , Yangyang Su , Ping Xu , Junjie Wang , Wenjie Liang , Cheng-Wu Liu , Jeremy D Murray

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36252014

Doi: doi.org/10.1073/pnas.2202606119

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Structural basis for product specificities of MLL family methyltransferases

Authors: Yanjing Li , Lijie Zhao , Yuebin Zhang , Ping Wu , Ying Xu , Jun Mencius , Yongxin Zheng , Xiaoman Wang , Wancheng Xu , Naizhe Huang , Xianwen Ye , Ming Lei , Pan Shi , Changlin Tian , Chao Peng , Guohui Li , Zhijun Liu , Shu Quan , Yong Chen

Journal: Mol Cell

PubMed ID: 36108631

Doi: 10.1016/j.molcel.2022.08.022

Products & Services: Peptide Synthesis

Human melanocortin-2 receptor: Identifying a role for residues in the TM4, EC2, and TM5 domains in activation and trafficking as a result of co-expression with the accessory protein, Mrap1 in Chinese Hamster Ovary Cells.

Authors: Perry V Davis , Ciaran A Shaughnessy , Robert M Dores

Journal: Biomolecules

PubMed ID: 36291631

Doi: 10.3390/biom12101422

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Labeling Ebola Virus with a Self-Splicing Fluorescent Reporter

Authors: Baylee Heiden , Elke Mühlberger , Christopher W Lennon , Adam J Hume

Journal: Microorganisms

PubMed ID: 36363701

Doi: 10.3390/microorganisms10112110

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Advanced pathway engineering for phototrophic putrescine production

Authors: Robert A Freudenberg , Luisa Wittemeier , Alexander Einhaus , Thomas Baier , Olaf Kruse

Journal: Plant Biotechnol J

PubMed ID: 35748533

Doi: 10.1111/pbi.13879

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Crystal structure of an L-type lectin domain from archaea

Authors: Farha Khan, Kaza Suguna

Journal: Proteins

PubMed ID: 36301308

Doi: 10.1002/prot.26440

Products & Services: PCR Cloning and Subcloning

Authors: Eyby Leon, Claris Nde, Randall S Ray, Diego Preciado, Irene E Zohn

Journal: Am J Med Genet A

PubMed ID: 36263470

Doi: 10.1002/ajmg.a.62991

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Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2

Authors: Phillip Pymm, Samuel J Redmond, Olan Dolezal, Francesca Mordant, Ester Lopez, James P Cooney, Kathryn C Davidson, Ebene R Haycroft, Chee Wah Tan, Rebecca Seneviratna, Samantha L Grimley, Damian F J Purcell, Stephen J Kent, Adam K Wheatley, Lin-Fa Wang, Andrew Leis, Alisa Glukhova, Marc Pellegrini, Amy W Chung, Kanta Subbarao, Adam P Uldrich, Wai-Hong Tham, Dale I Godfrey, Nicholas A Gherardin

Journal: iScience

PubMed ID: 36213007

Doi: 10.1016/j.isci.2022.105259

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SARS-CoV-2 Transmission from Human to Pet and Suspected Transmission from Pet to Human, Thailand

Authors: Chutchai Piewbang, Panida Poonsin, Pattiya Lohavicharn, Sabrina Wahyu Wardhani, Wichan Dankaona, Jiratchaya Puenpa, Yong Poovorawan, Somporn Techangamsuwan

Journal: J Clin Microbiol

PubMed ID: 36314788

Doi: 10.1128/jcm.01058-22

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Divergent SARS-CoV-2-specific T cell responses in intensive care unit workers following mRNA COVID-19 vaccination

Authors: Estefanía Salgado Del Riego, María Laura Saiz, Viviana Corte-Iglesias, Blanca Leoz Gordillo, Cristina Martin-Martin, Mercedes Rodríguez-Pérez, Dolores Escudero, Carlos Lopez-Larrea, Beatriz Suarez-Alvarez

Journal: Front Immunol

PubMed ID: 36275696

Doi: 10.3389/fimmu.2022.942192

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Antibody Response to Rotavirus C Pre-Farrow Natural Planned Exposure to Gilts and Their Piglets

Authors: Deepak Kumar, Amanda V Anderson, Jeremy Pittman, Nora L Springer, Douglas G Marthaler, Waithaka Mwangi

Journal: Viruses

PubMed ID: 36298806

Doi: 10.3390/v14102250

Products & Services: Mammalian Expression

The Therapeutic Effects of a PEDF-Derived Short Peptide on Murine Experimental Dry Eye Involves Suppression of MMP-9 and Inflammation

Authors: Tsung-Chuan Ho, Nai-Wen Fan, Shu-I Yeh, Show-Li Chen, Yeou-Ping Tsao

Journal: Transl Vis Sci Technol

PubMed ID: 36201200

Doi: 10.1167/tvst.11.10.12

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CD4-1 and CD8α T lymphocytes subsets in spotted sea bass (Lateolabrax maculatus) and comparison on antigenicity of T lymphocytes subsets in other three marine fish species

Authors: Xiaoyu Jiang, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan

Journal: Fish Shellfish Immunol

PubMed ID: 36210001

Doi: 10.1016/j.fsi.2022.10.004

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Velcrin-induced selective cleavage of tRNA(TAA) by SLFN12 causes cancer cell death

Authors: Sooncheol Lee, Stephanie Hoyt, Xiaoyun Wu, Colin Garvie, Joseph McGaunn, Mrinal Shekhar, Marcus Tötzl, Matthew G Rees, Andrew D Cherniack, Matthew Meyerson, Heidi Greulich

Journal: Nat Chem Biol

PubMed ID: 36302897

Doi: 10.1038/s41589-022-01170-9

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Loss of Chemerin in Rhabdomyosarcoma Cells Polarizes Adjacent Monocytes to an Immunosuppressive Phenotype

Authors: Rui Sun, Jia Le Lin, Man Si Cheng, Kang Yi Lee, Thilo Spruss, Christa Buechler, Herbert Schwarz

Journal: Biomedicines

PubMed ID: 36289872

Doi: 10.3390/biomedicines10102610

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IFITM3 promotes NiV envelope protein-mediated entry into MDCK cells and interacts with the fusion subunit of the F protein

Authors: Wang Xu, Shou-Wen Du, Le-Tian Li, Xiao-Shuang Shi, Jia-Min Wang, Ti-Yuan Li, Ning-Yi Jin, Chang Li

Journal: Int J Biochem Cell Biol

PubMed ID: 36330888

Doi: 10.1016/j.biocel.2022.106325

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The potential effects and mechanisms of Gegen Qinlian Decoction in oxaliplatin-resistant colorectal cancer based on network pharmacology

Authors: Xiang Lin, Li Xu, Huicheng Tan, Xinyi Zhang, Huan Shao, Li Yao, Xuan Huang

Journal: Heliyon

PubMed ID: 36353164

Doi: 10.1016/j.heliyon.2022.e11305

Products & Services: Protein Electrophoresis and Western

New mescaline-related N-acylhydrazone and its unsubstituted benzoyl derivative: Promising metallophores for copper-associated deleterious effects relief in Alzheimer's disease

Authors: Alessandra Carvalho, Barbara Marinho Barbosa, Jesica S Flores, Phelippe do Carmo Gonçalves, Renata Diniz, Yraima Cordeiro, Claudio O Fernández, Daphne S Cukierman, Nicolás A Rey

Journal: J Inorg Biochem

PubMed ID: 36396525

Doi: 10.1016/j.jinorgbio.2022.112033

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Modification of Hinge/Transmembrane and Signal Transduction Domains Improves the Expression and Signaling Threshold of GXMR-CAR Specific to spp

Authors: Matheus Henrique Dos Santos, Michele Procópio Machado, Pappanaicken R Kumaresan, Thiago Aparecido da Silva

Journal: Cells

PubMed ID: 36359781

Doi: 10.3390/cells11213386

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Impairment of antiviral immune response and disruption of cellular functions by SARS-CoV-2 ORF7a and ORF7b

Authors: Tránsito García-García, Raúl Fernández-Rodríguez, Natalia Redondo, Ana de Lucas-Rius, Sara Zaldívar-López, Blanca Dies López-Ayllón, José M Suárez-Cárdenas, Ángeles Jiménez-Marín, María Montoya, Juan J Garrido

Journal: iScience

PubMed ID: 36310646

Doi: 10.1016/j.isci.2022.105444

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Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases

Authors: Gretchen L Seim, Steven V John, Nicholas L Arp, Zixiang Fang, David J Pagliarini, Jing Fan

Journal: Nat Chem Biol

PubMed ID: 36266351

Doi: 10.1038/s41589-022-01153-w

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Correction to: Selection of DNA aptamer and its application as an electrical biosensor for Zika virus detection in human serum

Authors: Goeun Park, Myoungro Lee, Jiatong Kang, Chulwhan Park, Junhong Min, Taek Lee

Journal: Nano Converg

PubMed ID: 36315359

Doi: 10.1186/s40580-022-00340-8

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Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance

Authors: Jaël S Copier , Marianne Bootsma , Chai A Ng , Arthur A M Wilde , Robin A Bertels , Hennie Bikker , Imke Christiaans , Saskia N van der Crabben , Janna A Hol , Tamara T Koopmann , Jeroen Knijnenburg , Aafke A J Lommerse , Jasper J van der Smagt , Connie R Bezzina , Jamie I Vandenberg , Arie O Verkerk , Daniela Q C M Barge-Schaapveld , Elisabeth M Lodder

Journal: Hum Mol Genet

PubMed ID: 36269083

Doi: 10.1093/hmg/ddac261

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Metabolomic analysis of rapeseed priming with H2O2 in response to germination under chilling stress

Authors: Zhiwei Gu, Duan Wang, Qingtao Gong, Juan You, Qingji Ren, Haimei An, Yongyin Zhou, Haidong Jiang

Journal: Plant Growth Regulation

Doi: 10.1007/s10725-022-00918-6

Products & Services: Gene Synthesis

Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair

Authors: Oguz Bolgi, Maria Silva-Garcia, Breyan Ross, Esther Pilla, Vijayalakshmi Kari, Markus Killisch, Melanie Spitzner, Nadine Stark, Christof Lenz, Konstantin Weiss, Laura Donzelli, Mark D Gorrell, Marian Grade, Jan Riemer, Henning Urlaub, Matthias Dobbelstein, Robert Huber, Ruth Geiss-Friedlander

Journal: EMBO Reports

Doi: 10.15252/embr.202154136

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Available online 28 June 2022 0925-4005/© 2022 Elsevier B.V. All rights reserved. A universal CRISPR/Cas12a-mediated AuNPs aggregation-based surface-enhanced Raman scattering (CRISPR/Cas-SERS) platform for virus gene detection

Authors: Ailing Su ， Yuan Liu , Xiumian Cao , Weiqing Xu , Chongyang Liang , Shuping Xu

Journal: Sensors and Actuators B: Chemical

Doi: 10.1016/j.snb.2022.132295

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A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin

Authors: Qiyao Chai , Shanshan Yu, Yanzhao Zhong , Zhe Lu , Changgen Qiu, Yang Yu , Xinwen Zhang , Yong Zhang, Zehui Lei, Lihua Qiang, Bing-Xi Li, Yu Pang, Xiao-Bo Qiu, Jing Wang , Cui Hua Liu

Journal: Science .

PubMed ID: 36227980

Doi: 10.1126/science.abq0132

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Efficacy and safety of universal (TCRKO) ARI-0001 CAR-T cells for the treatment of B-cell lymphoma

Authors: Noelia Maldonado-Pérez, María Tristán-Manzano, Pedro Justicia-Lirio, Elena Martínez-Planes, Pilar Muñoz, Kristina Pavlovic, Marina Cortijo-Gutiérrez, Carlos Blanco-Benítez, María Castella, Manel Juan, Mathias Wenes, Pedro Romero, Francisco J Molina-Estévez, Concepción Marañón, Concha Herrera, Karim Benabdellah, Francisco Martin

Journal: Front Immunol

PubMed ID: 36275777

Doi: 10.3389/fimmu.2022.1011858

Products & Services: Recombinant Antibody Expression

CD8+ T cell clonotypes from prior SARS-CoV-2 infection predominate during the cellular immune response to mRNA vaccination

Authors: Emily S Ford, Koshlan Mayer-Blackwell, Lichen Jing, Anton M Sholukh, Russell St Germain, Emily L Bossard, Hong Xie, Thomas H Pulliam, Saumya Jani, Stacy Selke, Carlissa J Burrow, Christopher L McClurkan, Anna Wald, Michael R Holbrook, Brett Eaton, Elizabeth Eudy, Michael Murphy, Elena Postnikova, Harlan S Robins, Rebecca Elyanow, Rachel M Gittelman, Matyas Ecsedi, Elise Wilcox, Aude G Chapuis, Andrew Fiore-Gartland, David M Koelle

Journal: Res Sq

PubMed ID: 36263073

Doi: 10.21203/rs.3.rs-2146712/v1

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A bZIP transcription factor (CiFD) regulates drought and low temperature induced flowering by alternative splicing in citrus

Authors: Li-Xia Ye, Yan-Mei Wu, Jin-Xia Zhang, Jin-Xin Zhang, Huan Zhou, Ren-Fang Zeng, Wei-Xuan Zheng, Mei-Qi Qiu, Jing-Jing Zhou, Zong-Zhou Xie, Chun-Gen Hu, Jin-Zhi Zhang

Journal: J Integr Plant Biol

PubMed ID: 36250511

Doi: 10.1111/jipb.13390

Products & Services: Gene Fragments

Blocking Autophagy in M1 Macrophages Enhances Virus Replication and Eye Disease in Ocularly Infected Transgenic Mice

Authors: Ujjaldeep Jaggi, Harry H Matundan, Dhong Hyun Lee, Homayon Ghiasi

Journal: J Virol

PubMed ID: 36286481

Doi: 10.1128/jvi.01401-22

Products & Services: Mammalian Expression

Epitope of antiphospholipid antibodies retrieved from peptide microarray based on R39-R43 of β2-glycoprotein I

Authors: Marc Moghbel, Aline Roth, Daniela Baptista, Kapka Miteva, Fabienne Burger, Fabrizio Montecucco, Nicolas Vuilleumier, François Mach, Karim J Brandt

Journal: Res Pract Thromb Haemost

PubMed ID: 36304483

Doi: 10.1002/rth2.12828

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Apigenin suppresses mycoplasma-induced alveolar macrophages necroptosis via enhancing the methylation of TNF-α promoter by PPARγ-Uhrf1 axis

Authors: Xiuzhen Mei, Jian Wang, Chao Zhang, Jiale Zhu, Beibei Liu, Qingyun Xie, Ting Yuan, Yuzi Wu, Rong Chen, Xing Xie, Yanna Wei, Li Wang, Guoqing Shao, Qiyan Xiong, Yefen Xu, Zhixin Feng, Zhenzhen Zhang

Journal: Phytomedicine

PubMed ID: 36332388

Doi: 10.1016/j.phymed.2022.154504

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Combining mass spectrometry and machine learning to discover bioactive peptides

Authors: Christian T Madsen, Jan C Refsgaard, Felix G Teufel, Sonny K Kjærulff, Zhe Wang, Guangjun Meng, Carsten Jessen, Petteri Heljo, Qunfeng Jiang, Xin Zhao, Bo Wu, Xueping Zhou, Yang Tang, Jacob F Jeppesen, Christian D Kelstrup, Stephen T Buckley, Søren Tullin, Jan Nygaard-Jensen, Xiaoli Chen, Fang Zhang, Jesper V Olsen, Dan Han, Mads Grønborg, Ulrik de Lichtenberg

Journal: Nat Commun

PubMed ID: 36266275

Doi: 10.1038/s41467-022-34031-z

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Observation of conformational changes that underlie the catalytic cycle of Xrn2

Authors: Jan H Overbeck, David Stelzig, Anna-Lisa Fuchs, Jan Philip Wurm, Remco Sprangers

Journal: Nature Chemical Biology

PubMed ID: 36008487

Doi: 10.1038/s41589-022-01111-6

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Functional EGF domain of the human neuregulin 1α produced in Escherichia coli with accurate disulfide bonds

Authors: Arthur Schveitzer Ferreira, Amanda Lopacinski, Michel Batista, Priscila Mazzocchi Hiraiwa, Natalia Fernanda Bueno, Beatriz Gomes Guimarães, Nilson I T Zanchin

Journal: Mol Biol Rep

PubMed ID: 36198848

Doi: 10.1007/s11033-022-07956-3

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Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation

Authors: Yoshibumi Ueda, Yuri Miura, Nario Tomishige, Naotoshi Sugimoto, Megumi Murase, Genki Kawamura, Norihiko Sasaki, Toshiyuki Ishiwata, Takeaki Ozawa

Journal: Cell Chem Biol

PubMed ID: 36288730

Doi: 10.1016/j.chembiol.2022.10.002

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The Antimicrobial Peptide LJ-hep2 from Exerting Activities against Multiple Pathogenic Bacteria and Immune Protection In Vivo

Authors: Ruihao Gong, Zhe An, Weibin Zhang, Fangyi Chen, Ke-Jian Wang

Journal: Mar Drugs

PubMed ID: 36286474

Doi: 10.3390/md20100651

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Focused B cell response to recurring gluten motif with implications for epitope spreading in celiac disease

Authors: Chunyan Zhou, Thomas Østerbye, Emil Bach, Shiva Dahal-Koirala, Lene S Høydahl, Øyvind Steinsbø, Jørgen Jahnsen, Knut E A Lundin, Søren Buus, Ludvig M Sollid, Rasmus Iversen

Journal: Cell Rep

PubMed ID: 36288703

Doi: 10.1016/j.celrep.2022.111541

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Deciphering the Key Regulatory Roles of KLF6 and Bta-miR-148a on Milk Fat Metabolism in Bovine Mammary Epithelial Cells

Authors: Ambreen Iqbal, Haibin Yu, Ping Jiang, Zhihui Zhao

Journal: Genes (Basel)

PubMed ID: 36292712

Doi: 10.3390/genes13101828

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Investigating the Role of African Horse Sickness Virus VP7 Protein Crystalline Particles on Virus Replication and Release

Authors: Shani Bekker, Christiaan A Potgieter, Vida van Staden, Jacques Theron

Journal: Viruses

PubMed ID: 36298748

Doi: 10.3390/v14102193

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Glycoside hydrolase subfamily GH5_57 features a highly redesigned catalytic interface to process complex hetero-β-mannans

Authors: Marcele P Martins, Mariana A B Morais, Gabriela F Persinoti, Rafael H Galinari, Li Yu, Yoshihisa Yoshimi, Fernanda B Passos Nunes, Tatiani B Lima, Shayla F Barbieri, Joana L M Silveira, Vincent Lombard, Nicolas Terrapon, Paul Dupree, Bernard Henrissat, Mário T Murakami

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 36322419

Doi: 10.1107/S2059798322009561

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MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases

Authors: Zahra Mohtashami, Mithalesh K Singh, Nasim Salimiaghdam, Mustafa Ozgul, M Cristina Kenney

Journal: Int J Mol Sci

PubMed ID: 36233287

Doi: 10.3390/ijms231911991

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Inhibition of intermittent calcium-activated potassium channel (SK4) attenuates Ang II-induced hypertrophy of human-induced stem cell-derived cardiomyocytes via targeting Ras-Raf-MEK1/2-ERK1/2 and CN-NFAT signaling pathways

Authors: Hongyi Zhao, Xi Wang, Yanhong Tang, Qingyan Zhao, Congxin Huang

Journal: Cell Biol Int

PubMed ID: 36273427

Doi: 10.1002/cbin.11948

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Engineering Self-Assembled Endolysin Nanoparticles against Antibiotic-Resistant Bacteria

Authors: Christian K O Dzuvor, Bhuvana K Shanbhag, Tayyaba Younas, Hsin-Hui Shen, Victoria S Haritos, Lizhong He

Journal: ACS Appl Bio Mater

PubMed ID: 36194892

Doi: 10.1021/acsabm.2c00741

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Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains

Authors: Xingxing Chen, Yize Sun, Laiqiang Chen, Xiu-Sheng Chen, Mingtian Pan, Yiran Zhang, Qi Wang, Weili Yang, Peng Yin, Dajian He, Xiangyu Guo, Su Yang, Yan Zeng, Sen Yan, Xiao-Jiang Li, Shihua Li

Journal: Cell Mol Life Sci

PubMed ID: 36251080

Doi: 10.1007/s00018-022-04577-8

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Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose)

Authors: Jijin R A Kuttiyatveetil, Heddy Soufari, Morgan Dasovich, Isabel R Uribe, Manija Mirhasan, Shang-Jung Cheng, Anthony K L Leung, John M Pascal

Journal: Cell Rep

PubMed ID: 36288691

Doi: 10.1016/j.celrep.2022.111529

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Reverse genetics based H5N2 vaccine provides clinical protection against H5N1, H5N8 and H9N2 avian influenza infection in chickens

Authors: Sivasankar Panickan, Sandeep Bhatia, Sushant Bhat, Nisha Bhandari, Atul Kumar Pateriya, Semmannan Kalaiyarasu, Richa Sood, Meghna Tripathi

Journal: Vaccine

PubMed ID: 36374710

Doi: 10.1016/j.vaccine.2022.10.018

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Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins

Authors: Michael D Healy, Joanna Sacharz, Kerrie E McNally, Calum McConville, Vikas A Tillu, Ryan J Hall, Molly Chilton, Peter J Cullen, Mehdi Mobli, Rajesh Ghai, David A Stroud, Brett M Collins

Journal: Structure

PubMed ID: 36302387

Doi: 10.1016/j.str.2022.10.001

Products & Services: Mammalian Expression