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Enhancing epitope of PEDV spike protein
Authors: Techit Thavorasak, Monrat Chulanetra, Kittirat Glab-Ampai, Kodchakorn Mahasongkram, Nawannaporn Sae-Lim, Karsidete Teeranitayatarn, Thaweesak Songserm, Rungrueang Yodsheewan, Dachrit Nilubol, Wanpen Chaicumpa, Nitat Sookrung
Journal: Front Microbiol
PubMed ID: 35935230
Doi: 10.3389/fmicb.2022.933249
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Self-Assembling Protein Surfaces for Capture of Cell-Free-Synthesized Proteins
Authors: Ella Lucille Thornton, Sarah Maria Paterson, Zoe Gidden, Mathew H Horrocks, Nadanai Laohakunakorn, Lynne Regan
Journal: Front Bioeng Biotechnol
PubMed ID: 35875503
Doi: 10.3389/fbioe.2022.915035
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Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2
Authors: Brandon Wey-Hung Liauw, Arash Foroutan, Michael R Schamber, Weifeng Lu, Hamid Samareh Afsari, Reza Vafabakhsh
Journal: Elife
PubMed ID: 35775730
Doi: 10.7554/eLife.78982
Products & Services: DNA Sequencing   
Urinary CD8+HLA-DR+ T Cell Abundance Non-invasively Predicts Kidney Transplant Rejection
Authors: Emil Grothgar, Nina Goerlich, Bjoern Samans, Christopher M Skopnik, Diana Metzke, Jan Klocke, Luka Prskalo, Paul Freund, Leonie Wagner, Michael Duerr, Mareen Matz, Sven Olek, Klemens Budde, Alexander Paliege, Philipp Enghard
Journal: Front Med (Lausanne)
PubMed ID: 35911418
Doi: 10.3389/fmed.2022.928516
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Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP
Authors: Takeshi Yokoyama, Shiho Fujii, Andreas Ostermann, Tobias E Schrader, Yuko Nabeshima, Mineyuki Mizuguchi
Journal: IUCrJ
PubMed ID: 36071806
Doi: 10.1107/S2052252522006297
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Surface cysteine to serine substitutions in IL-18 reduce aggregation and enhance activity
Authors: Jirakrit Saetang, Niran Roongsawang, Surasak Sangkhathat, Supayang Piyawan Voravuthikunchai, Natnaree Sangkaew, Napat Prompat, Teerapol Srichana, Varomyalin Tipmanee
Journal: PeerJ
PubMed ID: 35811828
Doi: 10.7717/peerj.13626
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Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA
Authors: Qiuxia Chen, You Li, Chunrong Lin, Liu Chen, Hao Luo, Shuai Xia, Chuan Liu, Xuemin Cheng, Chengzhong Liu, Jin Li, Dengfeng Dou
Journal: Nucleic Acids Res
PubMed ID: 35288754
Doi: 10.1093/nar/gkac173
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Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition
Authors: Elena G Govorunova , Yueyang Gou , Oleg A Sineshchekov , Hai Li , Xiaoyu Lu , Yumei Wang , Leonid S Brown , François St-Pierre , Mingshan Xue , John L Spudich
Journal: Nature neuroscience
PubMed ID: 35726059
Doi: 10.1038/s41593-022-01094-6
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CaMKII Inhibition Attenuates Distinct Gain-of-Function Effects Produced by Mutant Nav16 Channels and Reduces Neuronal Excitability
Authors: Agnes S Zybura, Firoj K Sahoo, Andy Hudmon, Theodore R Cummins
Journal: Cells
PubMed ID: 35805192
Doi: 10.3390/cells11132108
Products & Services: Mammalian Expression   
Ancestrally Reconstructed von Willebrand Factor Reveals Evidence for Trench Warfare Coevolution between Opossums and Pit Vipers
Authors: Danielle H Drabeck, Alexandra Rucavado, Erika Hingst-Zaher, Antony Dean, Sharon A Jansa
Journal: Mol Biol Evol
PubMed ID: 35723968
Doi: 10.1093/molbev/msac140
Products & Services: Gene Synthesis   
Efficient multiplex CRISPR/Cpf1 (Cas12a) genome editing system in Aspergillus aculeatus TBRC 277
Authors: Dede Abdulrachman, Verawat Champreda, Lily Eurwilaichitr, Duriya Chantasingh, Kusol Pootanakit
Journal: J Biotechnol
PubMed ID: 35788357
Doi: 10.1016/j.jbiotec.2022.06.011
Products & Services: Synthetic Guide RNA   
Calcium responses to external mechanical stimuli in the multicellular stage of Dictyostelium discoideum
Authors: Hidenori Hashimura, Yusuke V Morimoto, Yusei Hirayama, Masahiro Ueda
Journal: Sci Rep
PubMed ID: 35859163
Doi: 10.1038/s41598-022-16774-3
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miR-301b-5p and its target gene nfatc2ip regulate inflammatory responses in the liver of rainbow trout (Oncorhynchus mykiss) under high temperature stress
Authors: Tianqing Huang, Wei Gu, Enhui Liu, Bingqian Wang, Gaochao Wang, Fulin Dong, Fuyuan Guo, Wenlong Jiao, Yanchun Sun, Xiance Wang, Shanwei Li, Gefeng Xu
Journal: Ecotoxicol Environ Saf
PubMed ID: 35901591
Doi: 10.1016/j.ecoenv.2022.113915
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An immunodetection assay developed using cobra cytotoxin-specific antibodies: Potential diagnostics for cobra envenoming
Authors: Hui Ling Ong, Choo Hock Tan, Louisa Pernee Lee, Sook Mei Khor, Kae Yi Tan
Journal: Toxicon
PubMed ID: 35868411
Doi: 10.1016/j.toxicon.2022.07.010
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A Single Dose of Anti-HBsAg Antibody-Encoding mRNA-LNPs Suppressed HBsAg Expression: a Potential Cure of Chronic Hepatitis B Virus Infection
Authors: Binfan Chen, Yuchen Chen, Jian Li, Chunyu Wang, Wenping Song, Yumei Wen, Jinzhong Lin, Yanling Wu, Tianlei Ying
Journal: MBio
PubMed ID: 35862767
Doi: 10.1128/mbio.01612-22
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RG203KR Mutations in SARS-CoV-2 Nucleocapsid: Assessing the Impact Using a Virus-Like Particle Model System
Authors: Harsha Raheja, Soma Das, Anindita Banerjee, Dikshaya P, Deepika C, Debanjan Mukhopadhyay, Subbaraya G Ramachandra, Saumitra Das
Journal: Microbiol Spectr
PubMed ID: 35862952
Doi: 10.1128/spectrum.00781-22
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Development of an in-house quantitative ELISA for the evaluation of different Covid-19 vaccines in humans
Authors: Mariem Gdoura, Fatma Ben Ghaloum, Meriem Ben Hamida, Wafa Chamsa, Henda Triki, Chokri Bahloul
Journal: Sci Rep
PubMed ID: 35788676
Doi: 10.1038/s41598-022-15378-1
Paraneoplastic Pemphigus Autoantibodies Against C-terminus of Desmoplakin Induced Acantholysis and
Authors: Xue Wang, Rui Wang, Dingfang Bu, Leyi Wang, Yuexin Zhang, Yuan Chang, Chenyang Zhang, Xixue Chen, Xuejun Zhu, Zhi Liu, Mingyue Wang
Journal: Front Immunol
PubMed ID: 35911677
Doi: 10.3389/fimmu.2022.886226
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Core cysteine residues in the Plasminogen-Apple-Nematode (PAN) domain are critical for HGF/c-MET signaling
Authors: Debjani Pal , Kuntal De , Carly M Shanks , Kai Feng , Timothy B Yates , Jennifer Morrell-Falvey , Russell B Davidson , Jerry M Parks , Wellington Muchero
Journal: Commun Biol
PubMed ID: 35778602
Doi: 10.1038/s42003-022-03582-8
Products & Services: Protein and Antibody Isolation   
Hsp70 inhibits the replication of Fowl Adenovirous serotype 4 by suppressing viral Hexon with the assistance of DnaJC7
Authors: Jie Cao , Shuhui Liu , Meng Liu , Shuaiwen Wang , Zhenwei Bi , Wentao Fan , Zhiyu Shi , Suquan Song , Liping Yan
Journal: J Virol
PubMed ID: 35852354
Doi: 10.1128/jvi.00807-22
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Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker
Authors: Aslan Mansurov , Peyman Hosseinchi, Kevin Chang, Abigail L Lauterbach, Laura T Gray , Aaron T Alpar , Erica Budina , Anna J Slezak , Seounghun Kang, Shijie Cao, Ani Solanki , Suzana Gomes , John-Michael Williford, Melody A Swartz , Juan L Mendoza , Jun Ishihara , Jeffrey A Hubbell
Journal: Nat Biomed Eng
PubMed ID: 35534574
Doi: 10.1038/s41551-022-00888-0
Products & Services: Mammalian Expression   
Identification of nucleoside monophosphates and their epigenetic modifications using an engineered nanopore.
Authors: Yuqin Wang , Shanyu Zhang , Wendong Jia ,Pingping Fan , Liying Wang , Xinyue Li , Jialu Chen , Zhenyuan Cao , Xiaoyu Du , Yao Liu , Kefan Wang , Chengzhen Hu , Jinyue Zhang , Jun Hu , Panke Zhang , Hong-Yuan Chen , Shuo Huang
Journal: Nat Nanotechnol
PubMed ID: 35851382
Doi: 10.1038/s41565-022-01169-2
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Oncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancer
Authors: Qiuman Wang , Xinyue Ma , Huan Wu , Chen Zhao 1, Jingying Chen , Rongrong Li , Shi Yan , Yingwei Li , Qing Zhang , Kun Song , Cunzhong Yuan , Beihua Kong
Journal: Oncoimmunology
PubMed ID: 35800156
Doi: 10.1080/2162402X.2022.2096362 Free PMC article
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Developing and validating SARS-CoV-2 assays for nonhuman primate surveillance
Authors: JoAnn Yee, Amanda Carpenter, Peter Nham, Bryson Halley, Koen K A Van Rompay, Jeffrey Roberts
Journal: J Med Primatol
PubMed ID: 35794847
Doi: 10.1111/jmp.12604
Products & Services: Mammalian Expression   
Conformational landscape of the yeast SAGA complex as revealed by cryo-EM
Authors: Diana Vasyliuk, Joeseph Felt, Ellen D Zhong, Bonnie Berger, Joseph H Davis, Calvin K Yip
Journal: Sci Rep
PubMed ID: 35853968
Doi: 10.1038/s41598-022-16391-0
Products & Services: Protein and Antibody Isolation   
Rhesus rotavirus receptor-binding site affects high mobility group box 1 release, altering the pathogenesis of experimental biliary atresia
Authors: Sujit K Mohanty, Bryan Donnelly, Haley Temple, Sarah Mowery, Holly M Poling, Jaroslaw Meller, Astha Malik, Monica McNeal, Greg Tiao
Journal: Hepatol Commun
PubMed ID: 35866580
Doi: 10.1002/hep4.2024
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Development and characterization of an inducible assay system to measure Zika virus capsid interactions
Authors: Jieshi Yu, Chen Huang, Zhao Wang, Radhey S Kaushik, Zizhang Sheng, Feng Li, Dan Wang
Journal: J Med Virol
PubMed ID: 35822280
Doi: 10.1002/jmv.27991
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Development and applications of a TaqMan based quantitative real-time PCR for the rapid detection of Pigeon circovirus (PiCV)
Authors: Babu K Nath, Shubhagata Das, Tridip Das, Jade K Forwood, Shane R Raidal
Journal: J Virol Methods
PubMed ID: 35870671
Doi: 10.1016/j.jviromet.2022.114588
Products & Services: Protein and Antibody Isolation   
Protective effects of small heat shock proteins in Daphnia magna against heavy metal exposure
Authors: Muyi Li, Ting Tang, Fengyu Yuan, Yuming Zhang, Fengchao Li, Fengsong Liu
Journal: Sci Total Environ
PubMed ID: 35907523
Doi: 10.1016/j.scitotenv.2022.157565
Products & Services: Protein and Antibody Isolation   
The transient expression of recombinant proteins in plant cell packs facilitates stable isotope labelling for NMR spectroscopy
Authors: Patrick Opdensteinen, Laura E Sperl, Mariam Mohamadi, Nicole Kündgen-Redding, Franz Hagn, Johannes Felix Buyel
Journal: Plant Biotechnol J
PubMed ID: 35702941
Doi: 10.1111/pbi.13873
Products & Services: Protein and Antibody Isolation   
SARS-CoV-2 Omicron escapes mRNA vaccine booster-induced antibody neutralisation in patients with autoimmune rheumatic diseases: an observational cohort study
Authors: Woo-Joong Kim, Seong-Ho Choi, Ji Young Park, Jung Soo Song, Jin-Won Chung, Sang Tae Choi
Journal: Ann Rheum Dis
PubMed ID: 35878999
Doi: 10.1136/ard-2022-222689
Screening circular RNAs with functional potential using the RfxCas13d/BSJ-gRNA system
Authors: Siqi Li, Hao Wu, Ling-Ling Chen
Journal: Nat Protoc
PubMed ID: 35831613
Doi: 10.1038/s41596-022-00715-5
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The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency Pathway
Authors: Lindsay C Sidak-Loftis, Kristin L Rosche, Natasha Pence, Jessica K Ujczo, Joanna Hurtado, Elis A Fisk, Alan G Goodman, Susan M Noh, John W Peters, Dana K Shaw
Journal: MBio
PubMed ID: 35862781
Doi: 10.1128/mbio.00703-22
Products & Services: Mammalian Expression   
In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus
Authors: Linda B Oyama, Hamza Olleik, Ana Carolina Nery Teixeira, Matheus M Guidini, James A Pickup, Brandon Yeo Pei Hui, Nicolas Vidal, Alan R Cookson, Hannah Vallin, Toby Wilkinson, Denise M S Bazzolli, Jennifer Richards, Mandy Wootton, Ralf Mikut, Kai Hilpert, Marc Maresca, Josette Perrier, Matthias Hess, Hilario C Mantovani, Narcis Fernandez-Fuentes, Christopher J Creevey, Sharon A Huws
Journal: NPJ Biofilms Microbiomes
PubMed ID: 35835775
Doi: 10.1038/s41522-022-00320-0
Products & Services: Protein and Antibody Isolation   
Development of Melioidosis Subunit Vaccines Using an Enzymatically Inactive Burkholderia pseudomallei AhpC
Authors: Lindsey K Schmidt, Caitlyn E Orne, Teresa L Shaffer, Shane M Wilson, Nittaya Khakhum, Alfredo G Torres, Paul J Brett, Mary N Burtnick
Journal: Infect Immun
PubMed ID: 35862715
Doi: 10.1128/iai.00222-22
Products & Services: Protein and Antibody Isolation   
Sequence grammar underlying the unfolding and phase separation of globular proteins
Authors: Kiersten M Ruff, Yoon Hee Choi, Dezerae Cox, Angelique R Ormsby, Yoochan Myung, David B Ascher, Sheena E Radford, Rohit V Pappu, Danny M Hatters
Journal: Mol Cell
PubMed ID: 35853451
Doi: 10.1016/j.molcel.2022.06.024
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Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos
Authors: Fanye Meng, Chenxi Xu, Kwang-Su Park, H Ümit Kaniskan, Gang Greg Wang, Jian Jin
Journal: J Med Chem
PubMed ID: 35895319
Doi: 10.1021/acs.jmedchem.2c00807
Products & Services: Plasmid DNA Preparation   
The Patterning and Proportion of Charged Residues in the Arginine-Rich Mixed-Charge Domain Determine the Membrane-Less Organelle Targeted by the Protein
Authors: Tamami Miyagi, Rio Yamazaki, Koji Ueda, Satoshi Narumi, Yuhei Hayamizu, Hiroshi Uji-I, Masahiko Kuroda, Kohsuke Kanekura
Journal: Int J Mol Sci
PubMed ID: 35887012
Doi: 10.3390/ijms23147658
Products & Services: Bacterial Expression   
Phage defence by deaminase-mediated depletion of deoxynucleotides in bacteria
Authors: Brian Y Hsueh, Geoffrey B Severin, Clinton A Elg, Evan J Waldron, Abhiruchi Kant, Alex J Wessel, John A Dover, Christopher R Rhoades, Benjamin J Ridenhour, Kristin N Parent, Matthew B Neiditch, Janani Ravi, Eva M Top, Christopher M Waters
Journal: Nat Microbiol
PubMed ID: 35817890
Doi: 10.1038/s41564-022-01162-4
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Cholesterol Deprivation Drives DHEA Biosynthesis in Human Adrenals
Authors: Emanuele Pignatti, Emre Murat Altinkilic, Konstantin Bräutigam, Michael Grössl, Aurel Perren, Mihaela Zavolan, Christa E Flück
Journal: Endocrinology
PubMed ID: 35583599
Doi: 10.1210/endocr/bqac076
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The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE mice
Authors: Yishi Shen, Hong-Mei Gu, Lei Zhai, Binxiang Wang, Shucun Qin, Da-Wei Zhang
Journal: Biochim Biophys Acta Mol Cell Biol Lipids
PubMed ID: 35803528
Doi: 10.1016/j.bbalip.2022.159196
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SARS-CoV-2 Epitopes following Infection and Vaccination Overlap Known Neutralizing Antibody Sites
Authors: Li Yang, Te Liang, Lane M Pierson, Hongye Wang, Jesse K Fletcher, Shu Wang, Duran Bao, Lili Zhang, Zhen Huang, Wenshu Zheng, Xiaomei Zhang, Heewon Park, Yuwen Li, James E Robinson, Amy K Feehan, Christopher J Lyon, Jing Cao, Lisa A Morici, Chenzhong Li, Chad J Roy, Xiaobo Yu, Tony Hu
Journal: Research (Wash D C)
PubMed ID: 35928300
Doi: 10.34133/2022/9769803
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An Engineered λ Phage Enables Enhanced and Strain-Specific Killing of Enterohemorrhagic Escherichia coli
Authors: Menglu Jin, Jingchao Chen, Xueyang Zhao, Guoru Hu, Hailei Wang, Zhi Liu, Wei-Hua Chen
Journal: Microbiol Spectr
PubMed ID: 35876591
Doi: 10.1128/spectrum.01271-22
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Development and Assessment of Herpes Simplex Virus Type 1 (HSV-1) Amplicon Vectors with Sensory Neuron-Selective Promoters
Authors: Charles Joussain, Olivier Le Coz, Andrey Pichugin, Peggy Marconi, Filip Lim, Mariaconcetta Sicurella, Keith Foster, François Giuliano, Alberto L Epstein, Alejandro Aranda Muñoz
Journal: Int J Mol Sci
PubMed ID: 35955608
Doi: 10.3390/ijms23158474
Products & Services: Gene Synthesis   
Reprogramming of Human B Cells from Secreting IgG to IgM by Genome Editing
Authors: Guigao Lin, Kuo Zhang, Yanxi Han, Rongxue Peng, Jiawei Zhang, Dandan Li, Jinming Li
Journal: CRISPR J
PubMed ID: 35900273
Doi: 10.1089/crispr.2021.0093
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Antitumor efficacy of MUC1-derived variable epitope library treatments in a mouse model of breast cancer
Authors: Josué Odales, Rodolfo Servín-Blanco, Fernando Martínez-Cortés, Jesus Guzman Valle, Allan Noé Domínguez-Romero, Goar Gevorkian, Karen Manoutcharian
Journal: Vaccine
PubMed ID: 35788294
Doi: 10.1016/j.vaccine.2022.06.062
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O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1
Authors: Qiang Zhu, Hong Zhou, Liming Wu, Zhenyuan Lai, Didi Geng, Weiwei Yang, Jie Zhang, Zhiya Fan, Weijie Qin, Yong Wang, Ruhong Zhou, Wen Yi
Journal: Nat Chem Biol
PubMed ID: 35879546
Doi: 10.1038/s41589-022-01085-5
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Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut
Authors: Víctor Taleb, Qinghua Liao, Yoshiki Narimatsu, Ana García-García, Ismael Compañón, Rafael Junqueira Borges, Andrés Manuel González-Ramírez, Francisco Corzana, Henrik Clausen, Carme Rovira, Ramon Hurtado-Guerrero
Journal: Nat Commun
PubMed ID: 35882872
Doi: 10.1038/s41467-022-32021-9
Products & Services: Mutagenesis Services   
Phage Particles of Controlled Length and Genome for Targeted Glioblastoma Imaging and Therapeutic Delivery
Authors: Uyanga Tsedev, Ching-Wei Lin, Gaelen T Hess, Jann N Sarkaria, Fred C Lam, Angela M Belcher
Journal: ACS Nano
PubMed ID: 35830573
Doi: 10.1021/acsnano.1c08720
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