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页码: 121/1027 每页显示数量

Nup98 Is Subverted from Annulate Lamellae by Hepatitis C Virus Core Protein to Foster Viral Assembly

Authors: Bertrand Boson, Chloé Mialon, Konstanze Schichl, Solène Denolly, François-Loïc Cosset

Journal: MBio

PubMed ID: 35258330

Doi: 10.1128/mbio.02923-21

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Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

Authors: Eva Mittler, Anna Z Wec, Janne Tynell, Pablo Guardado-Calvo, Julia Wigren-Byström, Laura C Polanco, Cecilia M O'Brien, Megan M Slough, Dafna M Abelson, Alexandra Serris, Mrunal Sakharkar, Gerard Pehau-Arnaudet, Russell R Bakken, James C Geoghegan, Rohit K Jangra, Markus Keller, Larry Zeitlin, Olli Vapalahti, Rainer G Ulrich, Zachary A Bornholdt, Clas Ahlm, Felix A Rey, John M Dye, Steven B Bradfute, Tomas Strandin, Andrew S Herbert, Mattias N E Forsell, Laura M Walker, Kartik Chandran

Journal: Sci Transl Med

PubMed ID: 35294259

Doi: 10.1126/scitranslmed.abl5399

Products & Services: Codon Optimization

Structural and mechanistic basis for redox sensing by the cyanobacterial transcription regulator RexT

Authors: Bin Li, Minshik Jo, Jianxin Liu, Jiayi Tian, Robert Canfield, Jennifer Bridwell-Rabb

Journal: Commun Biol

PubMed ID: 35347217

Doi: 10.1038/s42003-022-03226-x

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HSV-2-Specific Human Female Reproductive Tract Tissue Resident Memory T Cells Recognize Diverse HSV Antigens

Authors: David M Koelle, Lichun Dong, Lichen Jing, Kerry J Laing, Jia Zhu, Lei Jin, Stacy Selke, Anna Wald, Dana Varon, Meei-Li Huang, Christine Johnston, Lawrence Corey, Christine M Posavad

Journal: Front Immunol

PubMed ID: 35432373

Doi: 10.3389/fimmu.2022.867962

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Accurate positioning of functional residues with robotics-inspired computational protein design

Authors: Cody Krivacic, Kale Kundert, Xingjie Pan, Roland A Pache, Lin Liu, Shane O Conchúir, Jeliazko R Jeliazkov, Jeffrey J Gray, Michael C Thompson, James S Fraser, Tanja Kortemme

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35254891

Doi: 10.1073/pnas.2115480119

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Robust, Durable Gene Activation In Vivo via mRNA-Encoded Activators

Authors: Jared P Beyersdorf, Swapnil Bawage, Nahid Iglesias, Hannah E Peck, Ryan A Hobbs, Jay A Wroe, Chiara Zurla, Charles A Gersbach, Philip J Santangelo

Journal: ACS Nano

PubMed ID: 35357116

Doi: 10.1021/acsnano.1c10631

Products & Services: Gene Synthesis

Magnetic field-assisted aligned patterning in an alginate-silk fibroin/nanocellulose composite for guided wound healing

Authors: Keya Ganguly, Hexiu Jin, Sayan Deb Dutta, Dinesh K Patel, Tejal V Patil, Ki-Taek Lim

Journal: Carbohydr Polym

PubMed ID: 35422287

Doi: 10.1016/j.carbpol.2022.119321

Products & Services: Mammalian Expression

Characterization of SARS-CoV-2 Variants B16171 (Kappa), B16172 (Delta), and B1618 by Cell Entry and Immune Evasion

Authors: Wenlin Ren, Xiaohui Ju, Mingli Gong, Jun Lan, Yanying Yu, Quanxin Long, Devin J Kenney, Aoife K O'Connell, Yu Zhang, Jin Zhong, Guocai Zhong, Florian Douam, Xinquan Wang, Ailong Huang, Rong Zhang, Qiang Ding

Journal: MBio

PubMed ID: 35266815

Doi: 10.1128/mbio.00099-22

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A Novel Anti-CD73 Antibody That Selectively Inhibits Membrane CD73 Shows Antitumor Activity and Induces Tumor Immune Escape

Authors: Markus Kellner, Bettina von Neubeck, Bastian Czogalla, Regina Feederle, Binje Vick, Irmela Jeremias, Reinhard Zeidler

Journal: Biomedicines

PubMed ID: 35453575

Doi: 10.3390/biomedicines10040825

Products & Services: Gene Synthesis

Design of protein-binding proteins from the target structure alone

Authors: Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, William Sheffler, Joon Sung Park, Kevin M Jude, Iva Marković, Rameshwar U Kadam, Koen H G Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora Picton, Lauren Miller, Eva-Maria Strauch, Nicholas D DeBouver, Allison Pires, Asim K Bera, Samer Halabiya, Bradley Hammerson, Wei Yang, Steffen Bernard, Lance Stewart, Ian A Wilson, Hannele Ruohola-Baker, Joseph Schlessinger, Sangwon Lee, Savvas N Savvides, K Christopher Garcia, David Baker

Journal: Nature

PubMed ID: 35332283

Doi: 10.1038/s41586-022-04654-9

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Regulator of Actin-Based Motility (RoaM) Downregulates Actin Tail Formation by Rickettsia rickettsii and Is Negatively Selected in Mammalian Cell Culture

Authors: Adam M Nock, Tina R Clark, Ted Hackstadt

Journal: MBio

PubMed ID: 35285700

Doi: 10.1128/mbio.00353-22

Products & Services: Gene Synthesis

Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor

Authors: Haozhou Tan, Chunlong Ma, Jun Wang

Journal: Res Sq

PubMed ID: 35378761

Doi: 10.21203/rs.3.rs-1490282/v1

Products & Services: Codon Optimization

Interleukin-19 Aggravates Pulmonary Fibrosis via Activating Fibroblast through TGF-/Smad Pathway

Authors: Yu Wang, Sibo Sun, Kai Wang, Mingjiong Zhang, Min Li, Yumin Zan, Qiqing Huang, Shuangshuang Wu, Weihong Zhao, Wei Xu, Jianqing Wu

Journal: Mediators Inflamm

PubMed ID: 35281428

Doi: 10.1155/2022/6755407

Products & Services: Gene Synthesis

Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3-mediated regulation of actin filament assembly into the erythroblast membrane skeleton

Authors: Arit Ghosh, Megan Coffin, Richard West, Velia M Fowler

Journal: FASEB J

PubMed ID: 35195928

Doi: 10.1096/fj.202101011R

Products & Services: Catalog Peptides

Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine

Authors: Chung-Yi Wu, Cheng-Wei Cheng, Chih-Chuan Kung, Kuo-Shiang Liao, Jia-Tsrong Jan, Che Ma, Chi-Huey Wong

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35149556

Doi: 10.1073/pnas.2119995119

Products & Services: Codon Optimization

Superior antitumor immunotherapy efficacy of kynureninase modified CAR-T cells through targeting kynurenine metabolism

Authors: Quanjun Yang, Juan Hao, Mengyi Chi, Yaxian Wang, Bo Xin, Jinglu Huang, Jin Lu, Jie Li, Xipeng Sun, Chunyan Li, Yan Huo, Jianping Zhang, Yonglong Han, Cheng Guo

Journal: Oncoimmunology

PubMed ID: 35355679

Doi: 10.1080/2162402X.2022.2055703

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VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir41/51 Inward Rectifier Potassium Channels

Authors: Samantha J McClenahan, Caitlin N Kent, Sujay V Kharade, Elena Isaeva, Jade C Williams, Changho Han, Andrew Terker, Robert Gresham, Roman M Lazarenko, Emily L Days, Ian M Romaine, Joshua A Bauer, Olivier Boutaud, Gary A Sulikowski, Raymond Harris, C David Weaver, Alexander Staruschenko, Craig W Lindsley, Jerod S Denton

Journal: Mol Pharmacol

PubMed ID: 35246480

Doi: 10.1124/molpharm.121.000464

Products & Services: Gene Synthesis

Atomic resolution dynamics of cohesive interactions in phase-separated Nup98 FG domains

Authors: Eszter E Najbauer, Sheung Chun Ng, Christian Griesinger, Dirk Görlich, Loren B Andreas

Journal: Nat Commun

PubMed ID: 35314668

Doi: 10.1038/s41467-022-28821-8

Products & Services: GenParts™ DNA Fragments

Bmi-1 directly upregulates glucose transporter 1 in human gastric adenocarcinoma

Authors: Ying Guo, Guangyu Zhou, Qingjie Ma, Li Zhang, Jiwei Chen

Journal: Open Life Sci

PubMed ID: 35415241

Doi: 10.1515/biol-2022-0024

Products & Services: Gene Synthesis

Targeting lipophagy in macrophages improves repair in multiple sclerosis

Authors: Mansour Haidar, Melanie Loix, Sam Vanherle, Tess Dierckx, Tim Vangansewinkel, Pascal Gervois, Esther Wolfs, Ivo Lambrichts, Jeroen F J Bogie, Jerome J A Hendriks

Journal: Autophagy

PubMed ID: 35282773

Doi: 10.1080/15548627.2022.2047343

Products & Services: Endotoxin Detection & Removal System

Generation of Gal-enhanced bifunctional tumor vaccine

Authors: Jian He, Yu Huo, Zhikun Zhang, Yiqun Luo, Xiuli Liu, Qiaoying Chen, Pan Wu, Wei Shi, Tao Wu, Chao Tang, Huixue Wang, Lan Li, Xiyu Liu, Yong Huang, Yongxiang Zhao, Lu Gan, Bing Wang, Liping Zhong

Journal: Acta Pharm Sin B

PubMed ID: 35865091

Doi: 10.1016/j.apsb.2022.03.002

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Genome sequencing of a novel Microbacterium camelliasinensis CIAB417 identified potential mannan hydrolysing enzymes

Authors: Anjali Purohit, Sudesh Kumar Yadav

Journal: Int J Biol Macromol

PubMed ID: 35331789

Doi: 10.1016/j.ijbiomac.2022.03.093

Products & Services: Gene Synthesis

A rationally designed synthetic antimicrobial peptide against Pseudomonas-associated corneal keratitis: Structure-function correlation

Authors: Sk Abdul Mohid, Prerana Sharma, Amani Alghalayini, Tripti Saini, Debarun Datta, Mark D P Willcox, Haydar Ali, Sreyan Raha, Achintya Singha, DongKuk Lee, Nirakar Sahoo, Charles G Cranfield, Sanhita Roy, Anirban Bhunia

Journal: Biophys Chem

PubMed ID: 35605494

Doi: 10.1016/j.bpc.2022.106802

Products & Services: Catalog Peptides

Biodiversity and infrastructure interact to drive tourism to and within Costa Rica

Authors: Alejandra Echeverri, Jeffrey R Smith, Dylan MacArthur-Waltz, Katherine S Lauck, Christopher B Anderson, Rafael Monge Vargas, Irene Alvarado Quesada, Spencer A Wood, Rebecca Chaplin-Kramer, Gretchen C Daily

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35245152

Doi: 10.1073/pnas.2107662119

Products & Services: Plasmid DNA Preparation

Circ_0007611 stimulates IL-1 receptor accessory protein to inhibit trophoblast cell proliferation and induce cell apoptosis

Authors: Haiyan Xing, Qing Ding, Hong Lu, Qun Li

Journal: Biol Reprod

PubMed ID: 35238896

Doi: 10.1093/biolre/ioac028

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Enantioselectivity and key residue of Herbaspirillum huttiense monooxygenase in asymmetric epoxidation of styrenes

Authors: Shuang Dong, Donglin Fan, Qian Liu, Yinyin Meng, Xinyu Liu, Sen Yang, Hui Lin, Na Li, Hongge Chen

Journal: Appl Microbiol Biotechnol

PubMed ID: 35230494

Doi: 10.1007/s00253-022-11843-z

Products & Services: Proteins, Expression, Isolation and Analysis

Structural polymorphism of coiled-coils from the stalk domain of SARS-CoV-2 spike protein

Authors: Zala Živič, Žiga Strmšek, Marko Novinec, Jurij Lah, San Hadži

Journal: FASEB J

PubMed ID: 35157347

Doi: 10.1096/fj.202101670R

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Heat Shock Protein A6 Is Especially Involved in Enterovirus 71 Infection

Authors: Jiaoyan Jia, Ge Liu, Jianfeng Zhong, Ran Yan, Xun Song, Kai Zheng, Zhe Ren, Zhendan He, Qinchang Zhu

Journal: Front Microbiol

PubMed ID: 35308396

Doi: 10.3389/fmicb.2022.865644

Products & Services: Proteins, Expression, Isolation and Analysis

Pervasive translation in

Authors: Carol Smith, Jill G Canestrari, Archer J Wang, Matthew M Champion, Keith M Derbyshire, Todd A Gray, Joseph T Wade

Journal: Elife

PubMed ID: 35343439

Doi: 10.7554/eLife.73980

Products & Services: Proteins, Expression, Isolation and Analysis

Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior

Authors: Mikkel Bloss Carstensen, Adar Medvetzky, Alon Weinberger, Wolfgang Driever, Yoav Gothilf, Martin Fredensborg Rath

Journal: J Pineal Res

PubMed ID: 35249239

Doi: 10.1111/jpi.12795

Products & Services: Plasmid DNA Preparation

oligosaccharides increase serotonin in the brain and ameliorate depression promoting 5-hydroxytryptophan production in the gut microbiota

Authors: Zheng-Wei Zhang, Chun-Sheng Gao, Heng Zhang, Jian Yang, Ya-Ping Wang, Li-Bin Pan, Hang Yu, Chi-Yu He, Hai-Bin Luo, Zhen-Xiong Zhao, Xin-Bo Zhou, Yu-Li Wang, Jie Fu, Pei Han, Yu-Hui Dong, Gang Wang, Song Li, Yan Wang, Jian-Dong Jiang, Wu Zhong

Journal: Acta Pharm Sin B

PubMed ID: 35967282

Doi: 10.1016/j.apsb.2022.02.032

Products & Services: PCR Cloning and Subcloning

Activation mechanism of the class D fungal GPCR dimer Ste2

Authors: Vaithish Velazhahan, Ning Ma, Nagarajan Vaidehi, Christopher G Tate

Journal: Nature

PubMed ID: 35296853

Doi: 10.1038/s41586-022-04498-3

Products & Services: Proteins, Expression, Isolation and Analysis

Nephronectin-integrin α8 signaling is required for proper migration of periocular neural crest cells during chick corneal development

Authors: Justin Ma, Lian Bi, James Spurlin, Peter Lwigale

Journal: Elife

PubMed ID: 35238772

Doi: 10.7554/eLife.74307

Products & Services: PCR Cloning and Subcloning

Antibodies Targeting KSHV gH/gL Reveal Distinct Neutralization Mechanisms

Authors: Thomas Fricke, Anna K Großkopf, Armin Ensser, Marija Backovic, Alexander S Hahn

Journal: Viruses

PubMed ID: 35336948

Doi: 10.3390/v14030541

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Directed evolution of adeno-associated virus 5 capsid enables specific liver tropism

Authors: Yuqiu Wang, Chen Yang, Hanyang Hu, Chen Chen, Mengdi Yan, Feixiang Ling, Kathy Cheng Wang, Xintao Wang, Zhe Deng, Xinyue Zhou, Feixu Zhang, Sen Lin, Zengmin Du, Kai Zhao, Xiao Xiao

Journal: Mol Ther Nucleic Acids

PubMed ID: 35474733

Doi: 10.1016/j.omtn.2022.03.017

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Specificity and Reactivity of Serine/Threonine Kinases PknG and PknB

Authors: Osvaldo Burastero, Marisol Cabrera, Elias D Lopez, Lucas A Defelipe, Juan Pablo Arcon, Rosario Durán, Marcelo A Marti, Adrian G Turjanski

Journal: J Chem Inf Model

PubMed ID: 35319884

Doi: 10.1021/acs.jcim.1c01358

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A novel silk fibroin protein-based fusion system for enhancing the expression of nanobodies in Escherichia coli

Authors: Jianli Yu, Yang Guo, Yi Gu, Xiying Fan, Fei Li, Haipeng Song, Rui Nian, Wenshuai Liu

Journal: Appl Microbiol Biotechnol

PubMed ID: 35243528

Doi: 10.1007/s00253-022-11857-7

Products & Services: Proteins, Expression, Isolation and Analysis

Treatment Regimens for Transplant-Ineligible Patients With Newly Diagnosed Multiple Myeloma: A Systematic Literature Review and Network Meta-analysis

Authors: Thierry Facon, Jesús San-Miguel, Meletios A Dimopoulos, Maria-Victoria Mateos, Michele Cavo, Sophie van Beekhuizen, Zijiao Yuan, João Mendes, Annette Lam, Jianming He, Eric Ammann, Shaji Kumar

Journal: Adv Ther

PubMed ID: 35246820

Doi: 10.1007/s12325-022-02083-8

Products & Services: Gene Synthesis

Molnupiravir and Nirmatrelvir-Ritonavir: Oral COVID Antiviral Drugs

Authors: Louis D Saravolatz, Shawn Depcinski, Mamta Sharma

Journal: Clin Infect Dis

PubMed ID: 35245942

Doi: 10.1093/cid/ciac180

Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane Fusion

Authors: Chia-Jung Li, Tai-Ling Chao, Ting-Yu Chang, Chia-Chun Hsiao, De-Chao Lu, Yi-Wei Chiang, Guan-Chun Lai, Ya-Min Tsai, Jun-Tung Fang, Siman Ieong, Jann-Tay Wang, Sui-Yuan Chang, Shih-Chung Chang

Journal: Microbiol Spectr

PubMed ID: 35293796

Doi: 10.1128/spectrum.01814-21

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Characterization of UDP-glycosyltransferase family members reveals how major flavonoid glycoside accumulates in the roots of Scutellaria baicalensis

Authors: Tianlin Pei, Mengxiao Yan, Tian Li, Xiaoqiang Li, Yijia Yin, Mengying Cui, Yumin Fang, Jie Liu, Yu Kong, Ping Xu, Qing Zhao

Journal: BMC Genomics

PubMed ID: 35232374

Doi: 10.1186/s12864-022-08391-1

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Two independent cis-acting elements are required for the guard cell-specific expression of SCAP1, which is essential for late stomatal development

Authors: Kosuke Moriwaki, Shuichi Yanagisawa, Koh Iba, Juntaro Negi

Journal: Plant J

PubMed ID: 35061307

Doi: 10.1111/tpj.15679

Products & Services: GenParts™ DNA Fragments

Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model

Authors: Julie A Zorn, Matthew L Wheeler, Ralston M Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y-C Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop

Journal: Sci Rep

PubMed ID: 35241687

Doi: 10.1038/s41598-022-06953-7

Products & Services: Plasmid DNA Preparation

Theileria equi RAP-1a and RAP-1b proteins contain immunoreactive epitopes and are suitable candidates for vaccine and diagnostics development

Authors: Cynthia K Onzere, Lindsay M Fry, Richard P Bishop, Marta Da Silva, Sally A Madsen-Bouterse, Reginaldo G Bastos, Donald P Knowles, Carlos E Suarez

Journal: Int J Parasitol

PubMed ID: 35318949

Doi: 10.1016/j.ijpara.2022.01.004

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Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF melanoma

Authors: Lorey K Smith, Tiffany Parmenter, Margarete Kleinschmidt, Eric P Kusnadi, Jian Kang, Claire A Martin, Peter Lau, Riyaben Patel, Julie Lorent, David Papadopoli, Anna Trigos, Teresa Ward, Aparna D Rao, Emily J Lelliott, Karen E Sheppard, David Goode, Rodney J Hicks, Tony Tiganis, Kaylene J Simpson, Ola Larsson, Benjamin Blythe, Carleen Cullinane, Vihandha O Wickramasinghe, Richard B Pearson, Grant A McArthur

Journal: Nat Commun

PubMed ID: 35232962

Doi: 10.1038/s41467-022-28705-x

Products & Services: Mutant Libraries

Development of a p72 trimer-based colloidal gold strip for detection of antibodies against African swine fever virus

Authors: Rui Geng, Yaning Sun, Rui Li, Jifei Yang, Hongfang Ma, Zixuan Qiao, Qingxia Lu, Songlin Qiao, Gaiping Zhang

Journal: Appl Microbiol Biotechnol

PubMed ID: 35291024

Doi: 10.1007/s00253-022-11851-z

Products & Services: Proteins, Expression, Isolation and Analysis

Baohuoside I Inhibits Tumor Angiogenesis in Multiple Myeloma the Peroxisome Proliferator-Activated Receptor γ/Vascular Endothelial Growth Factor Signaling Pathway

Authors: Ying Chen, Lina Zhang, Xiaoyan Zang, Xuxing Shen, Jianyong Li, Lijuan Chen

Journal: Front Pharmacol

PubMed ID: 35341213

Doi: 10.3389/fphar.2022.822082

Products & Services: Plasmid DNA Preparation

Development and Validation of a Competitive ELISA Based on Bovine Monoclonal Antibodies for the Detection of Neutralizing Antibodies against Foot-and-Mouth Disease Virus Serotype A

Authors: Yimei Cao, Kun Li, Xiangchuan Xing, Guoqiang Zhu, Yuanfang Fu, Huifang Bao, Xingwen Bai, Pu Sun, Pinghua Li, Jing Zhang, Xueqing Ma, Jian Wang, Zhixun Zhao, Dong Li, Zaixin Liu, Zengjun Lu

Journal: J Clin Microbiol

PubMed ID: 35254106

Doi: 10.1128/jcm.02142-21

Products & Services: Recombinant Proteins

Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy

Authors: Juan Qin, Jingfeng Zhang, Lianyun Lin, Omid Haji-Ghassemi, Zhi Lin, Kenneth J Woycechowsky, Filip Van Petegem, Yan Zhang, Zhiguang Yuchi

Journal: Elife

PubMed ID: 35297759

Doi: 10.7554/eLife.75346

Products & Services: Mutant Libraries

ClpX/P-Dependent Degradation of Novel Substrates in Streptococcus mutans

Authors: Vivek Gurung, Indranil Biswas

Journal: J Bacteriol

PubMed ID: 35343773

Doi: 10.1128/jb.00594-21

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