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Proline-Rich Region II (PRR2) Plays an Important Role in Tau-Glycan Interaction: An NMR Study

Authors: Anqesha Murray, Lufeng Yan, James M Gibson, Jian Liu, David Eliezer, Guy Lippens, Fuming Zhang, Robert J Linhardt, Jing Zhao, Chunyu Wang

Journal: Biomolecules

PubMed ID: 36358923

Doi: 10.3390/biom12111573

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Durability of antibodies post vaccination with two doses of inactivated BBIBP-CorV vaccine

Authors: Sally Mahmoud, Subhashini Ganesan, Narjes Saheb Sharif-Askari, Flavia Cantarutti, Hannah Wilson, Pauline Ogrodzki, Rabih Halwani, Nawal Alkaabi, Walid Abbas Zaher

Journal: Curr Med Res Opin

PubMed ID: 36274640

Doi: 10.1080/03007995.2022.2139969

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The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation

Authors: Radwa E Mahgoub, Feda E Mohamed, Lara Alzyoud, Bassam R Ali, Juliana Ferreira, Wael M Rabeh, Shaikha S AlNeyadi, Noor Atatreh, Mohammad A Ghattas

Journal: Molecules

PubMed ID: 36235244

Doi: 10.3390/molecules27196710

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Quantum Dot-Based Screening Identifies F3 Peptide and Reveals Cell Surface Nucleolin as a Therapeutic Target for Rhabdomyosarcoma

Authors: Dzhangar Dzhumashev, Andrea Timpanaro, Safa Ali, Andrea J De Micheli, Kamel Mamchaoui, Ilaria Cascone, Jochen Rössler, Michele Bernasconi

Journal: Cancers (Basel)

PubMed ID: 36291832

Doi: 10.3390/cancers14205048

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Establishment of a protocol for preventive vaccination against equine insect bite hypersensitivity

Authors: Sara Bjork Stefansdottir, Sigridur Jonsdottir, Holmfridur Kristjansdottir, Vilhjalmur Svansson, Eliane Marti, Sigurbjorg Torsteinsdottir

Journal: Vet Immunol Immunopathol

PubMed ID: 36272211

Doi: 10.1016/j.vetimm.2022.110502

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Development and in vitro characterization of a humanized scFv against fungal infections

Authors: Tomas Di Mambro, Tania Vanzolini, Marzia Bianchi, Rita Crinelli, Barbara Canonico, Filippo Tasini, Michele Menotta, Mauro Magnani

Journal: PLoS ONE

PubMed ID: 36315567

Doi: 10.1371/journal.pone.0276786

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De novo design of anti-tuberculosis agents using a structure-based deep learning method

Authors: Sowmya Ramaswamy Krishnan, Navneet Bung, Siladitya Padhi, Gopalakrishnan Bulusu, Parimal Misra, Manojit Pal, Srinivas Oruganti, Rajgopal Srinivasan, Arijit Roy

Journal: J Mol Graph Model

PubMed ID: 36257148

Doi: 10.1016/j.jmgm.2022.108361

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Prostaglandin E synchronizes lunar-regulated beach spawning in grass puffers

Authors: Junfeng Chen, Yuma Katada, Kousuke Okimura, Taiki Yamaguchi, Ying-Jey Guh, Tomoya Nakayama, Michiyo Maruyama, Yuko Furukawa, Yusuke Nakane, Naoyuki Yamamoto, Yoshikatsu Sato, Hironori Ando, Asako Sugimura, Kazufumi Tabata, Ayato Sato, Takashi Yoshimura

Journal: Curr Biol

PubMed ID: 36306789

Doi: 10.1016/j.cub.2022.09.062

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Deciphering the virulence potential of Listeria monocytogenes in the Norwegian meat and salmon processing industry by combining whole genome sequencing and in vitro data

Authors: Eva Wagner, Annette Fagerlund, Sarah Thalguter, Merete Rusås Jensen, Even Heir, Trond Møretrø, Birgitte Moen, Solveig Langsrud, Kathrin Rychli

Journal: Int J Food Microbiol

PubMed ID: 36240603

Doi: 10.1016/j.ijfoodmicro.2022.109962

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Deciphering the Immunogenicity of Monkeypox Proteins for Designing the Potential mRNA Vaccine

Authors: Mohibullah Shah; Samavia Jaan; Muhammad Shehroz; Asifa Sarfraz; Khamna Asad; Tehreem Ul Wara; Aqal Zaman; Riaz Ullah; Essam A. Ali; Umar Nishan; Suvash Chandra Ojha

Journal: ACS Omega

PubMed ID: 38024731

Doi: 10.1021/acsomega.3c07866

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Deciphering the Immunogenicity of Monkeypox Proteins for Designing the Potential mRNA Vaccine

Authors: Mohibullah Shah; Samavia Jaan; Muhammad Shehroz; Asifa Sarfraz; Khamna Asad; Tehreem Ul Wara; Aqal Zaman; Riaz Ullah; Essam A. Ali; Umar Nishan; Suvash Chandra Ojha

Journal: ACS Omega

PubMed ID: 38024731

Doi: 10.1021/acsomega.3c07866

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Fructose-6-phosphate-2-kinase/fructose-2,6-bisphosphatase regulates energy metabolism and synthesis of storage products in developing rice endosperm

Authors: Xiaoli Chen , Yi Ji , Weiying Zhao , Huanying Niu , Xue Yang , Xiaokang Jiang , Yipeng Zhang , Jie Lei , Hang Yang , Rongbo Chen , Chuanwei Gu , Hongyi Xu , Hui Dong , Erchao Duan , Xuan Teng , Yunlong Wang , Yuanyan Zhang , Wenwei Zhang , Yihua Wang , Jianmin Wan

Journal: Plant Sci

PubMed ID: 36270512

Doi: 10.1016/j.plantsci.2022.111503

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Isobutanol production by combined and metabolic engineering

Authors: Mamta Gupta, Matthew Wong, Kamran Jawed, Kamil Gedeon, Hannah Barrett, Marcelo Bassalo, Clifford Morrison, Danish Eqbal, Syed Shams Yazdani, Ryan T Gill, Jiaqi Huang, Marc Douaisi, Jonathan Dordick, Georges Belfort, Mattheos A G Koffas

Journal: Metab Eng Commun

PubMed ID: 36325486

Doi: 10.1016/j.mec.2022.e00210

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The Detection of Immunity against WT1 and SMAD4 of EpCAM Cancer Cells in Malignant Pleural Effusion

Authors: Terutsugu Koya, Yo Niida, Misa Togi, Kenichi Yoshida, Takuya Sakamoto, Hiroki Ura, Sumihito Togi, Tomohisa Kato, Sohsuke Yamada, Haruo Sugiyama, Shigeo Koido, Shigetaka Shimodaira

Journal: Int J Mol Sci

PubMed ID: 36293034

Doi: 10.3390/ijms232012177

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DNA damage-induced nuclear import of HSP90α is promoted by Aha1

Authors: Nupur Fangaria, Khushboo Rani, Priyanka Singh, Sandeep Dey, Kota Arun Kumar, Sunanda Bhattacharyya

Journal: Mol Biol Cell

PubMed ID: 36260391

Doi: 10.1091/mbc.E21-11-0554

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Identification of human MHC-I HPV18 E6/E7-specific CD8 + T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice

Authors: Shiwen Peng, Deyin Xing, Louise Ferrall, Ya-Chea Tsai, Chien-Fu Hung, T-C Wu

Journal: J Biomed Sci

PubMed ID: 36224625

Doi: 10.1186/s12929-022-00864-5

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A broadly protective vaccine against cutaneous human papillomaviruses

Authors: Filipe Colaco Mariz, Kathrin Balz, Manuela Dittrich, Yueru Zhang, Fan Yang, Xueer Zhao, Angelo Bolchi, Simone Ottonello, Martin Müller

Journal: npj Vaccines

PubMed ID: 36216845

Doi: 10.1038/s41541-022-00539-0

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Comparison of the kinetics and magnitude of antibody responses to different SARS-CoV-2 proteins in Sinopharm/BBIBP-CorV vaccinees following the BNT162b2 booster or natural infection

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Shashika Dayarathna, Thashmi Nimasha, Thushali Ranasinghe, Jeewantha Jayamali, Achala Kamaladasa, Maneshka Karunanada, Lahiru Perera, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: PLoS ONE

PubMed ID: 36227884

Doi: 10.1371/journal.pone.0274845

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Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination

Authors: Jia Xin Chua, Lindy Gillian Durrant, Yin Ling Chok, Oi Ming Lai

Journal: iScience

PubMed ID: 36277260

Doi: 10.1016/j.isci.2022.105379

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A novel rhesus macaque model of Huntington's disease recapitulates key neuropathological changes along with motor and cognitive decline

Authors: Alison R Weiss, William A Liguore, Kristin Brandon, Xiaojie Wang, Zheng Liu, Jacqueline S Domire, Dana Button, Sathya Srinivasan, Christopher D Kroenke, Jodi L McBride

Journal: Elife

PubMed ID: 36205397

Doi: 10.7554/eLife.77568

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Comparative proteomic analysis reveals novel insights into the continuous cropping induced response in Scrophularia ningpoensis

Authors: Jiachen Sun, Xuejiao Li, Zhuo Qu, Huairui Wang, Yao Cheng, Shengjie Dong, Hui Zhao

Journal: J Sci Food Agric

PubMed ID: 36271763

Doi: 10.1002/jsfa.12284

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A dataset comprised of binding interactions for 104,972 antibodies against a SARS-CoV-2 peptide

Authors: Emily Engelhart, Ryan Emerson, Leslie Shing, Chelsea Lennartz, Daniel Guion, Mary Kelley, Charles Lin, Randolph Lopez, David Younger, Matthew E Walsh

Journal: Sci Data

PubMed ID: 36289234

Doi: 10.1038/s41597-022-01779-4

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Autophagic flux restoration enhances the antitumor efficacy of tumor infiltrating lymphocytes

Authors: Chaoting Zhang, Yizhe Sun, Shance Li, Luyan Shen, Xia Teng, Yefei Xiao, Nan Wu, Zheming Lu

Journal: J Immunother Cancer

PubMed ID: 36307150

Doi: 10.1136/jitc-2022-004868

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ICG-Dimeric Her2-Specific Affibody Conjugates for Tumor Imaging and Photothermal Therapy for Her2-Positive Tumors

Authors: Dianlong Jia, Huimin Liu, Shuhui Zheng, Dandan Yuan, Ruohan Sun, Fei Wang, Yang Li, Hui Li, Fengjiao Yuan, Qing Fan, Zhenxiong Zhao

Journal: Mol Pharm

PubMed ID: 36315025

Doi: 10.1021/acs.molpharmaceut.2c00708

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A method for targeting a specified segment of DNA to a bacterial microorganelle

Authors: Jan Otoničar, Maja Hostnik, Maja Grundner, Rok Kostanjšek, Tajda Gredar, Maja Garvas, Zoran Arsov, Zdravko Podlesek, Cene Gostinčar, Jernej Jakše, Stephen J W Busby, Matej Butala

Journal: Nucleic Acids Res

PubMed ID: 36029110

Doi: 10.1093/nar/gkac714

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An inducible gene from glycoside hydrolase one family of decreases larval survival when feeding on host plant

Authors: Wei Chen, Yuhong Dong, Ling Zheng, Yingfang Lai, Feifei Li, Li Zhou, Beibei Wang, Minsheng You, Weiyi He

Journal: Front Physiol

PubMed ID: 36338470

Doi: 10.3389/fphys.2022.1013092

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Combating the SARS-CoV-2 Omicron (BA1) and BA2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies

Authors: Yingdan Wang, Xiang Zhang, Yunping Ma, Yanqun Wang, Wuqiang Zhan, Qinwen Zheng, Meng Zhang, Ping Ji, Mei Liu, Qianying Liu, Tingting Sun, Tongyu Zhu, Yumei Wen, Lei Sun, Jincun Zhao, Fan Wu, Zhenguo Chen, Jinghe Huang

Journal: Cell Discov

PubMed ID: 36207299

Doi: 10.1038/s41421-022-00463-6

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Active Pharmaceutical Ingredient Uptake by Zebrafish (Danio rerio) Oct2 (slc22a2) Transporter Expressed in Xenopus laevis Oocytes

Authors: Elisabeth D Chang, Stewart F Owen, Christer Hogstrand, Nic R Bury

Journal: Environ Toxicol Chem

PubMed ID: 36102855

Doi: 10.1002/etc.5480

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Transient State Kinetics of Apicoplast DNA Polymerase Suggests the Involvement of Accessory Factors for Efficient and Accurate DNA Synthesis

Authors: Anamika Kumari, Anjali Yadav, Indrajit Lahiri

Journal: Biochemistry

PubMed ID: 36251801

Doi: 10.1021/acs.biochem.2c00446

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A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction

Authors: John T Happ, Corvin D Arveseth, Jessica Bruystens, Daniela Bertinetti, Isaac B Nelson, Cristina Olivieri, Jingyi Zhang, Danielle S Hedeen, Ju-Fen Zhu, Jacob L Capener, Jan W Bröckel, Lily Vu, C C King, Victor L Ruiz-Perez, Xuecai Ge, Gianluigi Veglia, Friedrich W Herberg, Susan S Taylor, Benjamin R Myers

Journal: Nat Struct Mol Biol

PubMed ID: 36202993

Doi: 10.1038/s41594-022-00838-z

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Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation

Authors: Wen-Hsin Lee, Xiaorui Chen, I-Ju Liu, Jiin-Horng Lee, Chun-Mei Hu, Han-Chung Wu, Sheng-Kai Wang, Wen-Hwa Lee, Che Ma

Journal: Cell Rep

PubMed ID: 36288706

Doi: 10.1016/j.celrep.2022.111555

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Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity

Authors: Brett H Pogostin, Marina H Yu, Alon R Azares, Erin M Euliano, Cheuk Sun Edwin Lai, Gabriel Saenz, Samuel X Wu, Adam C Farsheed, Sarah M Melhorn, Tyler P Graf, Darren G Woodside, Jeffrey D Hartgerink, Kevin J McHugh

Journal: Biomater Sci

PubMed ID: 36102692

Doi: 10.1039/d2bm01242a

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Evasion of cGAS and TRIM5 defines pandemic HIV

Authors: Lorena Zuliani-Alvarez, Morten L Govasli, Jane Rasaiyaah, Chris Monit, Stephen O Perry, Rebecca P Sumner, Simon McAlpine-Scott, Claire Dickson, K M Rifat Faysal, Laura Hilditch, Richard J Miles, Frederic Bibollet-Ruche, Beatrice H Hahn, Till Boecking, Nikos Pinotsis, Leo C James, David A Jacques, Greg J Towers

Journal: Nat Microbiol

PubMed ID: 36289397

Doi: 10.1038/s41564-022-01247-0

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Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

Authors: Tilman L B Hölting, Florencia Cidre-Aranaz, Dana Matzek, Bastian Popper, Severin J Jacobi, Cornelius M Funk, Florian H Geyer, Jing Li, Ignazio Piseddu, Bruno L Cadilha, Stephan Ledderose, Jennifer Zwilling, Shunya Ohmura, David Anz, Annette Künkele, Frederick Klauschen, Thomas G P Grünewald, Maximilian M L Knott

Journal: Mol Cancer

PubMed ID: 36229873

Doi: 10.1186/s12943-022-01641-6

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Cancer stem cell antigen nanodisc cocktail elicits anti-tumor immune responses in melanoma

Authors: Marisa E Aikins, You Qin, Hannah E Dobson, Alireza Hassani Najafabadi, Kexing Lyu, Yao Xu, Ying Xin, Anna Schwendeman, Max S Wicha, Alfred E Chang, Qiao Li, James J Moon

Journal: J Control Release

PubMed ID: 36206945

Doi: 10.1016/j.jconrel.2022.09.061

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Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library

Authors: Devan J Shell, Justin M Rectenwald, Peter H Buttery, Rebecca L Johnson, Caroline A Foley, Shiva K R Guduru, Mélanie Uguen, Juanita Sanchez Rubiano, Xindi Zhang, Fengling Li, Jacqueline L Norris-Drouin, Matthew Axtman, P Brian Hardy, Masoud Vedadi, Stephen V Frye, Lindsey I James, Kenneth H Pearce

Journal: SLAS Discov

PubMed ID: 36272689

Doi: 10.1016/j.slasd.2022.10.003

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Energy landscape reshaped by strain-specific mutations underlies epistasis in NS1 evolution of influenza A virus

Authors: Iktae Kim, Alyssa Dubrow, Bryan Zuniga, Baoyu Zhao, Noah Sherer, Abhishek Bastiray, Pingwei Li, Jae-Hyun Cho

Journal: Nat Commun

PubMed ID: 36182933

Doi: 10.1038/s41467-022-33554-9

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GITRL impairs the immunosuppressive function of MDSCs via PTEN-mediated signaling pathway in experimental Sjögren syndrome

Authors: Jie Tian, Beibei Zhang, Qingfang Yuan, Xueqing Sun, Na Peng, Bo Zhu, Chang Liu, Xiaoran Wang, Man Han, Meng Cao, Fan Xiao, Shengjun Wang, Ke Rui, Liwei Lu

Journal: Inflamm Res

PubMed ID: 36301339

Doi: 10.1007/s00011-022-01660-5

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An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation

Authors: Merve Avar, Daniel Heinzer, Alana M Thackray, Yingjun Liu, Marian Hruska-Plochan, Stefano Sellitto, Elke Schaper, Daniel P Pease, Jiang-An Yin, Asvin Kk Lakkaraju, Marc Emmenegger, Marco Losa, Andra Chincisan, Simone Hornemann, Magdalini Polymenidou, Raymond Bujdoso, Adriano Aguzzi

Journal: EMBO J

PubMed ID: 36254605

Doi: 10.15252/embj.2022112338

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Priming conditions shape breadth of neutralizing antibody responses to sarbecoviruses

Authors: Janice Zhirong Jia, Chee Wah Tan, Samuel M S Cheng, Haogao Gu, Aileen Ying Yan Yeoh, Chris Ka Pun Mok, Yanqun Wang, Jincun Zhao, Nancy H L Leung, Benjamin J Cowling, Leo L M Poon, David S C Hui, Linfa Wang, Malik Peiris, Sophie A Valkenburg

Journal: Nat Commun

PubMed ID: 36271047

Doi: 10.1038/s41467-022-34038-6

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Inhibition of Glypican-3 Cleavage Results in Reduced Cell Proliferation in a Liver Cancer Cell Line

Authors: Emily J Schepers, Charissa Lake, Kathryn Glaser, Alexander J Bondoc

Journal: J Surg Res

PubMed ID: 36272230

Doi: 10.1016/j.jss.2022.09.011

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Macromolecular crowding amplifies allosteric regulation of T-Cell Protein Tyrosine Phosphatase

Authors: May Thwe Tun, Shen Yang, Fabio Luis Forti, Eugenio Santelli, Nunzio Bottini

Journal: J Biol Chem

PubMed ID: 36328244

Doi: 10.1016/j.jbc.2022.102655

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The large plasmid carried class 1 integrons mediated multidrug resistance of foodborne Indiana

Authors: Xuefeng Wang, Tian Wang, Mengjiao Guo, Chengcheng Zhang, Zongyi Bo, Yantao Wu, Guoxiang Chao

Journal: Front Microbiol

PubMed ID: 36312970

Doi: 10.3389/fmicb.2022.991326

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Multifunctional chemical inhibitors of the florigen activation complex discovered by structure-based high-throughput screening

Authors: Ken-Ichiro Taoka, Ikumi Kawahara, Shoko Shinya, Ken-Ichi Harada, Eiki Yamashita, Zenpei Shimatani, Kyoko Furuita, Tomoaki Muranaka, Tokitaka Oyama, Rie Terada, Atsushi Nakagawa, Toshimichi Fujiwara, Hiroyuki Tsuji, Chojiro Kojima

Journal: Plant J

PubMed ID: 36288411

Doi: 10.1111/tpj.16008

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Development and characterization of a new monoclonal antibody against SARS-CoV-2 NSP12 (RdRp)

Authors: Wen Meng, Siying Guo, Simon Cao, Masahiro Shuda, Lindsey R Robinson-McCarthy, Kevin R McCarthy, Yoko Shuda, Alberto E Paniz Mondolfi, Clare Bryce, Zachary Grimes, Emilia M Sordillo, Carlos Cordon-Cardo, Pengfei Li, Hu Zhang, Stanley Perlman, Haitao Guo, Shou-Jiang Gao, Yuan Chang, Patrick S Moore

Journal: J Med Virol

PubMed ID: 36271490

Doi: 10.1002/jmv.28246

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A simple thermodynamic description of phase separation of Nup98 FG domains

Authors: Sheung Chun Ng, Dirk Görlich

Journal: Nat Commun

PubMed ID: 36257947

Doi: 10.1038/s41467-022-33697-9

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Sex Difference Leads to Differential Gene Expression Patterns and Therapeutic Efficacy in Mucopolysaccharidosis IVA Murine Model Receiving AAV8 Gene Therapy

Authors: Matthew Piechnik, Paige C Amendum, Kazuki Sawamoto, Molly Stapleton, Shaukat Khan, Nidhi Fnu, Victor Álvarez, Angelica Maria Herreño Pachon, Olivier Danos, Joseph T Bruder, Subha Karumuthil-Melethil, Shunji Tomatsu

Journal: Int J Mol Sci

PubMed ID: 36293546

Doi: 10.3390/ijms232012693

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External quality assessment of SARS-CoV-2 serology in European expert laboratories, April 2021

Authors: Ramona Mögling, Francesca Colavita, Johan Reimerink, Angeliki Melidou, Katrin Leitmeyer, Maria Keramarou, Daniele Lapa, Massimo Francalancia, Jean-Luc Murk, Ann Vossen, Fabrizio Carletti, Boris Hogema, Adam Meijer, Liesbet Deprez, Antonino di Caro, Concetta Castilletti, Chantal Bem Reusken

Journal: Euro Surveill

PubMed ID: 36268736

Doi: 10.2807/1560-7917.ES.2022.27.42.2101057

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Upregulation of programmed cell death 1 by interferon gamma and its biological functions in human monocytes

Authors: Kittitach Sri-Ngern-Ngam, Pornlapat Keawvilai, Trairak Pisitkun, Tanapat Palaga

Journal: Biochem Biophys Rep

PubMed ID: 36275930

Doi: 10.1016/j.bbrep.2022.101369

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Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage

Authors: Qianying Lv, Xinli Han, Jiajia Ni, Qianqian Ma, Rufeng Dai, Jiaojiao Liu, Jialu Liu, Yihui Zhai, Qian Shen, Li Sun, Haimei Liu, Jia Rao, Hong Xu

Journal: Cell Death Dis

PubMed ID: 36229446

Doi: 10.1038/s41419-022-05313-7

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