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页码: 120/1026 每页显示数量

Non-binary Encoded Nucleic Acid Barcodes Directly Readable by a Nanopore

Authors: Shuanghong Yan , Liying Wang , Yuqin Wang , Zhenyuan Cao , Shanyu Zhang , Xiaoyu Du , Pingping Fan , Panke Zhang , Hong-Yuan Chen , Shuo Huang

Journal: Angew Chem Int Ed Engl

PubMed ID: 35261129

Doi: 10.1002/anie.202116482

Products & Services: Plasmid DNA Preparation

Comparative genomics reveal the convergent evolution of CYP82D and CYP706X members related to flavone biosynthesis in Lamiaceae and Asteraceae

Authors: Ranran Gao, Qian Lou, Lijun Hao, Guihong Qi, Ya Tian, Xiangdong Pu, Chunnian He, Yu Wang, Wenjie Xu, Zhichao Xu, Jingyuan Song

Journal: Plant J

PubMed ID: 34907610

Doi: 10.1111/tpj.15634

Products & Services: Gene Synthesis

Unusual (2R,6R)-bicyclo[3.1.1]heptane ring construction in fungal a-trans-bergamotene biosynthesis

Authors: Yan-Hua Wen , Tian-Jiao Chen , Long-Yu Jiang , Li Li , Mengbo Guo , Yu Peng , Jing-Jing Chen , Fei Pei , Jin-Ling Yang , Rui-Shan Wang , Ting Gong , Ping Zhu

Journal: iScience

PubMed ID: 35345459

Doi: 10.1016/j.isci.2022.104030

Products & Services: Gene Synthesis

Structural Insight into KsBcl-2 Mediated Apoptosis Inhibition by Kaposi Sarcoma Associated Herpes Virus

Authors: Chathura D Suraweera , Mark G Hinds , Marc Kvansakul

Journal: Viruses

PubMed ID: 35458468

Doi: 10.3390/v14040738

Products & Services: Gene Synthesis

Lactobacillus murinus alleviate intestinal ischemia/reperfusion injury through promoting the release of interleukin-10 from M2 macrophages via Toll-like receptor 2 signaling

Authors: Jingjuan Hu, Fan Deng, Bingcheng Zhao, Zebin Lin, Qishun Sun, Xiao Yang, Mei Wu, Shida Qiu, Yu Chen, Zhengzheng Yan, Sidan Luo, Jin Zhao, Weifeng Liu, Cai Li, Ke Xuan Liu

Journal: Microbiome

PubMed ID: 35241180

Doi: 10.1186/s40168-022-01227-w

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular characterization, immunofluorescent localization, and expression levels of two bicarbonate anion transporters in the whitish mantle of the giant clam, Tridacna squamosa, and the implications for light-enhanced shell formation

Authors: Mel V Boo, Caryn Z Pang, Shit F Chew, Yuen K Ip

Journal: Comp Biochem Physiol A Mol Integr Physiol

PubMed ID: 35337976

Doi: 10.1016/j.cbpa.2022.111200

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Fine Mapping of the Region Identified rs7175517 as a Causal Variant Related to BMI in China and the United Kingdom Populations

Authors: Ce Lu, Hai-Jun Wang, Jie-Yun Song, Shuo Wang, Xue-Ying Li, Tao Huang, Hui Wang

Journal: Front Genet

PubMed ID: 35368675

Doi: 10.3389/fgene.2022.838685

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Dynamic observation of SARS-CoV-2 IgM, IgG, and neutralizing antibodies in the development of population immunity through COVID-19 vaccination

Authors: Ruiwei Jiang, Xiaowen Dou, Min Li, Enyun Wang, Jiwen Hu, Dan Xiong, Xiuming Zhang

Journal: J Clin Lab Anal

PubMed ID: 35235705

Doi: 10.1002/jcla.24325

Angiotensin (1-7) peptide replacement therapy with plasma transfusion in COVID-19

Authors: Hasan Onal, Nurcan Ucuncu Ergun, Bengu Arslan, Seyma Topuz, Seda Yilmaz Semerci, Osman Mutluhan Ugurel, Murat Topuzogullari, Ali Kalkan, Sengul Aydin Yoldemir, Nurettin Suner, Ali Kocatas

Journal: Transfus Apher Sci

PubMed ID: 35305923

Doi: 10.1016/j.transci.2022.103418

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Comparative Network Biology Discovers Protein Complexes That Underline Cellular Differentiation in Anabaena sp

Authors: Chen Xu, Bing Wang, Hailu Heng, Jiangmei Huang, Cuihong Wan

Journal: Mol Cell Proteomics

PubMed ID: 35288331

Doi: 10.1016/j.mcpro.2022.100224

Products & Services: Proteins, Expression, Isolation and Analysis

Nup98 Is Subverted from Annulate Lamellae by Hepatitis C Virus Core Protein to Foster Viral Assembly

Authors: Bertrand Boson, Chloé Mialon, Konstanze Schichl, Solène Denolly, François-Loïc Cosset

Journal: MBio

PubMed ID: 35258330

Doi: 10.1128/mbio.02923-21

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Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

Authors: Eva Mittler, Anna Z Wec, Janne Tynell, Pablo Guardado-Calvo, Julia Wigren-Byström, Laura C Polanco, Cecilia M O'Brien, Megan M Slough, Dafna M Abelson, Alexandra Serris, Mrunal Sakharkar, Gerard Pehau-Arnaudet, Russell R Bakken, James C Geoghegan, Rohit K Jangra, Markus Keller, Larry Zeitlin, Olli Vapalahti, Rainer G Ulrich, Zachary A Bornholdt, Clas Ahlm, Felix A Rey, John M Dye, Steven B Bradfute, Tomas Strandin, Andrew S Herbert, Mattias N E Forsell, Laura M Walker, Kartik Chandran

Journal: Sci Transl Med

PubMed ID: 35294259

Doi: 10.1126/scitranslmed.abl5399

Products & Services: Codon Optimization

Structural and mechanistic basis for redox sensing by the cyanobacterial transcription regulator RexT

Authors: Bin Li, Minshik Jo, Jianxin Liu, Jiayi Tian, Robert Canfield, Jennifer Bridwell-Rabb

Journal: Commun Biol

PubMed ID: 35347217

Doi: 10.1038/s42003-022-03226-x

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Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane Fusion

Authors: Chia-Jung Li, Tai-Ling Chao, Ting-Yu Chang, Chia-Chun Hsiao, De-Chao Lu, Yi-Wei Chiang, Guan-Chun Lai, Ya-Min Tsai, Jun-Tung Fang, Siman Ieong, Jann-Tay Wang, Sui-Yuan Chang, Shih-Chung Chang

Journal: Microbiol Spectr

PubMed ID: 35293796

Doi: 10.1128/spectrum.01814-21

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Two independent cis-acting elements are required for the guard cell-specific expression of SCAP1, which is essential for late stomatal development

Authors: Kosuke Moriwaki, Shuichi Yanagisawa, Koh Iba, Juntaro Negi

Journal: Plant J

PubMed ID: 35061307

Doi: 10.1111/tpj.15679

Products & Services: GenParts™ DNA Fragments

Magnetic field-assisted aligned patterning in an alginate-silk fibroin/nanocellulose composite for guided wound healing

Authors: Keya Ganguly, Hexiu Jin, Sayan Deb Dutta, Dinesh K Patel, Tejal V Patil, Ki-Taek Lim

Journal: Carbohydr Polym

PubMed ID: 35422287

Doi: 10.1016/j.carbpol.2022.119321

Products & Services: Mammalian Expression

A Novel Anti-CD73 Antibody That Selectively Inhibits Membrane CD73 Shows Antitumor Activity and Induces Tumor Immune Escape

Authors: Markus Kellner, Bettina von Neubeck, Bastian Czogalla, Regina Feederle, Binje Vick, Irmela Jeremias, Reinhard Zeidler

Journal: Biomedicines

PubMed ID: 35453575

Doi: 10.3390/biomedicines10040825

Products & Services: Gene Synthesis

A novel silk fibroin protein-based fusion system for enhancing the expression of nanobodies in Escherichia coli

Authors: Jianli Yu, Yang Guo, Yi Gu, Xiying Fan, Fei Li, Haipeng Song, Rui Nian, Wenshuai Liu

Journal: Appl Microbiol Biotechnol

PubMed ID: 35243528

Doi: 10.1007/s00253-022-11857-7

Products & Services: Proteins, Expression, Isolation and Analysis

Treatment Regimens for Transplant-Ineligible Patients With Newly Diagnosed Multiple Myeloma: A Systematic Literature Review and Network Meta-analysis

Authors: Thierry Facon, Jesús San-Miguel, Meletios A Dimopoulos, Maria-Victoria Mateos, Michele Cavo, Sophie van Beekhuizen, Zijiao Yuan, João Mendes, Annette Lam, Jianming He, Eric Ammann, Shaji Kumar

Journal: Adv Ther

PubMed ID: 35246820

Doi: 10.1007/s12325-022-02083-8

Products & Services: Gene Synthesis

Structural polymorphism of coiled-coils from the stalk domain of SARS-CoV-2 spike protein

Authors: Zala Živič, Žiga Strmšek, Marko Novinec, Jurij Lah, San Hadži

Journal: FASEB J

PubMed ID: 35157347

Doi: 10.1096/fj.202101670R

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Molnupiravir and Nirmatrelvir-Ritonavir: Oral COVID Antiviral Drugs

Authors: Louis D Saravolatz, Shawn Depcinski, Mamta Sharma

Journal: Clin Infect Dis

PubMed ID: 35245942

Doi: 10.1093/cid/ciac180

Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF melanoma

Authors: Lorey K Smith, Tiffany Parmenter, Margarete Kleinschmidt, Eric P Kusnadi, Jian Kang, Claire A Martin, Peter Lau, Riyaben Patel, Julie Lorent, David Papadopoli, Anna Trigos, Teresa Ward, Aparna D Rao, Emily J Lelliott, Karen E Sheppard, David Goode, Rodney J Hicks, Tony Tiganis, Kaylene J Simpson, Ola Larsson, Benjamin Blythe, Carleen Cullinane, Vihandha O Wickramasinghe, Richard B Pearson, Grant A McArthur

Journal: Nat Commun

PubMed ID: 35232962

Doi: 10.1038/s41467-022-28705-x

Products & Services: Mutant Libraries

Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine

Authors: Chung-Yi Wu, Cheng-Wei Cheng, Chih-Chuan Kung, Kuo-Shiang Liao, Jia-Tsrong Jan, Che Ma, Chi-Huey Wong

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35149556

Doi: 10.1073/pnas.2119995119

Products & Services: Codon Optimization

Heat Shock Protein A6 Is Especially Involved in Enterovirus 71 Infection

Authors: Jiaoyan Jia, Ge Liu, Jianfeng Zhong, Ran Yan, Xun Song, Kai Zheng, Zhe Ren, Zhendan He, Qinchang Zhu

Journal: Front Microbiol

PubMed ID: 35308396

Doi: 10.3389/fmicb.2022.865644

Products & Services: Proteins, Expression, Isolation and Analysis

Pervasive translation in

Authors: Carol Smith, Jill G Canestrari, Archer J Wang, Matthew M Champion, Keith M Derbyshire, Todd A Gray, Joseph T Wade

Journal: Elife

PubMed ID: 35343439

Doi: 10.7554/eLife.73980

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of UDP-glycosyltransferase family members reveals how major flavonoid glycoside accumulates in the roots of Scutellaria baicalensis

Authors: Tianlin Pei, Mengxiao Yan, Tian Li, Xiaoqiang Li, Yijia Yin, Mengying Cui, Yumin Fang, Jie Liu, Yu Kong, Ping Xu, Qing Zhao

Journal: BMC Genomics

PubMed ID: 35232374

Doi: 10.1186/s12864-022-08391-1

Products & Services: GenParts™ DNA Fragments

Generation of Gal-enhanced bifunctional tumor vaccine

Authors: Jian He, Yu Huo, Zhikun Zhang, Yiqun Luo, Xiuli Liu, Qiaoying Chen, Pan Wu, Wei Shi, Tao Wu, Chao Tang, Huixue Wang, Lan Li, Xiyu Liu, Yong Huang, Yongxiang Zhao, Lu Gan, Bing Wang, Liping Zhong

Journal: Acta Pharm Sin B

PubMed ID: 35865091

Doi: 10.1016/j.apsb.2022.03.002

Products & Services: Custom Vector Construction

Robust, Durable Gene Activation In Vivo via mRNA-Encoded Activators

Authors: Jared P Beyersdorf, Swapnil Bawage, Nahid Iglesias, Hannah E Peck, Ryan A Hobbs, Jay A Wroe, Chiara Zurla, Charles A Gersbach, Philip J Santangelo

Journal: ACS Nano

PubMed ID: 35357116

Doi: 10.1021/acsnano.1c10631

Products & Services: Gene Synthesis

Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model

Authors: Julie A Zorn, Matthew L Wheeler, Ralston M Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y-C Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop

Journal: Sci Rep

PubMed ID: 35241687

Doi: 10.1038/s41598-022-06953-7

Products & Services: Plasmid DNA Preparation

Regulator of Actin-Based Motility (RoaM) Downregulates Actin Tail Formation by Rickettsia rickettsii and Is Negatively Selected in Mammalian Cell Culture

Authors: Adam M Nock, Tina R Clark, Ted Hackstadt

Journal: MBio

PubMed ID: 35285700

Doi: 10.1128/mbio.00353-22

Products & Services: Gene Synthesis

A rationally designed synthetic antimicrobial peptide against Pseudomonas-associated corneal keratitis: Structure-function correlation

Authors: Sk Abdul Mohid, Prerana Sharma, Amani Alghalayini, Tripti Saini, Debarun Datta, Mark D P Willcox, Haydar Ali, Sreyan Raha, Achintya Singha, DongKuk Lee, Nirakar Sahoo, Charles G Cranfield, Sanhita Roy, Anirban Bhunia

Journal: Biophys Chem

PubMed ID: 35605494

Doi: 10.1016/j.bpc.2022.106802

Products & Services: Catalog Peptides

Circ_0007611 stimulates IL-1 receptor accessory protein to inhibit trophoblast cell proliferation and induce cell apoptosis

Authors: Haiyan Xing, Qing Ding, Hong Lu, Qun Li

Journal: Biol Reprod

PubMed ID: 35238896

Doi: 10.1093/biolre/ioac028

Products & Services: Catalog Antibody

Enantioselectivity and key residue of Herbaspirillum huttiense monooxygenase in asymmetric epoxidation of styrenes

Authors: Shuang Dong, Donglin Fan, Qian Liu, Yinyin Meng, Xinyu Liu, Sen Yang, Hui Lin, Na Li, Hongge Chen

Journal: Appl Microbiol Biotechnol

PubMed ID: 35230494

Doi: 10.1007/s00253-022-11843-z

Products & Services: Proteins, Expression, Isolation and Analysis

VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir41/51 Inward Rectifier Potassium Channels

Authors: Samantha J McClenahan, Caitlin N Kent, Sujay V Kharade, Elena Isaeva, Jade C Williams, Changho Han, Andrew Terker, Robert Gresham, Roman M Lazarenko, Emily L Days, Ian M Romaine, Joshua A Bauer, Olivier Boutaud, Gary A Sulikowski, Raymond Harris, C David Weaver, Alexander Staruschenko, Craig W Lindsley, Jerod S Denton

Journal: Mol Pharmacol

PubMed ID: 35246480

Doi: 10.1124/molpharm.121.000464

Products & Services: Gene Synthesis

Atomic resolution dynamics of cohesive interactions in phase-separated Nup98 FG domains

Authors: Eszter E Najbauer, Sheung Chun Ng, Christian Griesinger, Dirk Görlich, Loren B Andreas

Journal: Nat Commun

PubMed ID: 35314668

Doi: 10.1038/s41467-022-28821-8

Products & Services: GenParts™ DNA Fragments

Bmi-1 directly upregulates glucose transporter 1 in human gastric adenocarcinoma

Authors: Ying Guo, Guangyu Zhou, Qingjie Ma, Li Zhang, Jiwei Chen

Journal: Open Life Sci

PubMed ID: 35415241

Doi: 10.1515/biol-2022-0024

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Targeting lipophagy in macrophages improves repair in multiple sclerosis

Authors: Mansour Haidar, Melanie Loix, Sam Vanherle, Tess Dierckx, Tim Vangansewinkel, Pascal Gervois, Esther Wolfs, Ivo Lambrichts, Jeroen F J Bogie, Jerome J A Hendriks

Journal: Autophagy

PubMed ID: 35282773

Doi: 10.1080/15548627.2022.2047343

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Characterization of SARS-CoV-2 Variants B16171 (Kappa), B16172 (Delta), and B1618 by Cell Entry and Immune Evasion

Authors: Wenlin Ren, Xiaohui Ju, Mingli Gong, Jun Lan, Yanying Yu, Quanxin Long, Devin J Kenney, Aoife K O'Connell, Yu Zhang, Jin Zhong, Guocai Zhong, Florian Douam, Xinquan Wang, Ailong Huang, Rong Zhang, Qiang Ding

Journal: MBio

PubMed ID: 35266815

Doi: 10.1128/mbio.00099-22

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Design of protein-binding proteins from the target structure alone

Authors: Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, William Sheffler, Joon Sung Park, Kevin M Jude, Iva Marković, Rameshwar U Kadam, Koen H G Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora Picton, Lauren Miller, Eva-Maria Strauch, Nicholas D DeBouver, Allison Pires, Asim K Bera, Samer Halabiya, Bradley Hammerson, Wei Yang, Steffen Bernard, Lance Stewart, Ian A Wilson, Hannele Ruohola-Baker, Joseph Schlessinger, Sangwon Lee, Savvas N Savvides, K Christopher Garcia, David Baker

Journal: Nature

PubMed ID: 35332283

Doi: 10.1038/s41586-022-04654-9

Products & Services: Plasmid DNA Preparation

Antibodies Targeting KSHV gH/gL Reveal Distinct Neutralization Mechanisms

Authors: Thomas Fricke, Anna K Großkopf, Armin Ensser, Marija Backovic, Alexander S Hahn

Journal: Viruses

PubMed ID: 35336948

Doi: 10.3390/v14030541

Products & Services: Catalog Antibody

Theileria equi RAP-1a and RAP-1b proteins contain immunoreactive epitopes and are suitable candidates for vaccine and diagnostics development

Authors: Cynthia K Onzere, Lindsay M Fry, Richard P Bishop, Marta Da Silva, Sally A Madsen-Bouterse, Reginaldo G Bastos, Donald P Knowles, Carlos E Suarez

Journal: Int J Parasitol

PubMed ID: 35318949

Doi: 10.1016/j.ijpara.2022.01.004

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Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor

Authors: Haozhou Tan, Chunlong Ma, Jun Wang

Journal: Res Sq

PubMed ID: 35378761

Doi: 10.21203/rs.3.rs-1490282/v1

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Biodiversity and infrastructure interact to drive tourism to and within Costa Rica

Authors: Alejandra Echeverri, Jeffrey R Smith, Dylan MacArthur-Waltz, Katherine S Lauck, Christopher B Anderson, Rafael Monge Vargas, Irene Alvarado Quesada, Spencer A Wood, Rebecca Chaplin-Kramer, Gretchen C Daily

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35245152

Doi: 10.1073/pnas.2107662119

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Superior antitumor immunotherapy efficacy of kynureninase modified CAR-T cells through targeting kynurenine metabolism

Authors: Quanjun Yang, Juan Hao, Mengyi Chi, Yaxian Wang, Bo Xin, Jinglu Huang, Jin Lu, Jie Li, Xipeng Sun, Chunyan Li, Yan Huo, Jianping Zhang, Yonglong Han, Cheng Guo

Journal: Oncoimmunology

PubMed ID: 35355679

Doi: 10.1080/2162402X.2022.2055703

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HSV-2-Specific Human Female Reproductive Tract Tissue Resident Memory T Cells Recognize Diverse HSV Antigens

Authors: David M Koelle, Lichun Dong, Lichen Jing, Kerry J Laing, Jia Zhu, Lei Jin, Stacy Selke, Anna Wald, Dana Varon, Meei-Li Huang, Christine Johnston, Lawrence Corey, Christine M Posavad

Journal: Front Immunol

PubMed ID: 35432373

Doi: 10.3389/fimmu.2022.867962

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Accurate positioning of functional residues with robotics-inspired computational protein design

Authors: Cody Krivacic, Kale Kundert, Xingjie Pan, Roland A Pache, Lin Liu, Shane O Conchúir, Jeliazko R Jeliazkov, Jeffrey J Gray, Michael C Thompson, James S Fraser, Tanja Kortemme

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35254891

Doi: 10.1073/pnas.2115480119

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Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior

Authors: Mikkel Bloss Carstensen, Adar Medvetzky, Alon Weinberger, Wolfgang Driever, Yoav Gothilf, Martin Fredensborg Rath

Journal: J Pineal Res

PubMed ID: 35249239

Doi: 10.1111/jpi.12795

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oligosaccharides increase serotonin in the brain and ameliorate depression promoting 5-hydroxytryptophan production in the gut microbiota

Authors: Zheng-Wei Zhang, Chun-Sheng Gao, Heng Zhang, Jian Yang, Ya-Ping Wang, Li-Bin Pan, Hang Yu, Chi-Yu He, Hai-Bin Luo, Zhen-Xiong Zhao, Xin-Bo Zhou, Yu-Li Wang, Jie Fu, Pei Han, Yu-Hui Dong, Gang Wang, Song Li, Yan Wang, Jian-Dong Jiang, Wu Zhong

Journal: Acta Pharm Sin B

PubMed ID: 35967282

Doi: 10.1016/j.apsb.2022.02.032

Products & Services: PCR Cloning and Subcloning

Activation mechanism of the class D fungal GPCR dimer Ste2

Authors: Vaithish Velazhahan, Ning Ma, Nagarajan Vaidehi, Christopher G Tate

Journal: Nature

PubMed ID: 35296853

Doi: 10.1038/s41586-022-04498-3

Products & Services: Proteins, Expression, Isolation and Analysis

Nephronectin-integrin α8 signaling is required for proper migration of periocular neural crest cells during chick corneal development

Authors: Justin Ma, Lian Bi, James Spurlin, Peter Lwigale

Journal: Elife

PubMed ID: 35238772

Doi: 10.7554/eLife.74307

Products & Services: PCR Cloning and Subcloning

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