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PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer

Authors: Shoshana Sedley, Jeetendra Kumar Nag, Tatyana Rudina, Rachel Bar-Shavit

Journal: Int J Mol Sci

PubMed ID: 35955891

Doi: 10.3390/ijms23158758

Products & Services: Plasmid DNA Preparation

High-level de novo biosynthesis of cordycepin by systems metabolic engineering in Yarrowia lipolytica

Authors: Xi-Yu Duan, Yun Tian, Ze-Qi Song, Li-Ping Song, Wen-Bo Lin, Chong Wang, Hui Yang, Xiang-Yang Lu, Xiao-Jun Ji, Hu-Hu Liu

Journal: Bioresour Technol

PubMed ID: 36041680

Doi: 10.1016/j.biortech.2022.127862

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Reduced Immune Response to Inactivated Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine in a Cohort of Immunocompromised Patients in Chile

Authors: M Elvira Balcells, Nicole Le Corre, Josefina Durán, María Elena Ceballos, Cecilia Vizcaya, Sebastián Mondaca, Martín Dib, Ricardo Rabagliati, Mauricio Sarmiento, Paula I Burgos, Manuel Espinoza, Marcela Ferrés, Constanza Martinez-Valdebenito, Cinthya Ruiz-Tagle, Catalina Ortiz, Patricio Ross, Sigall Budnik, Sandra Solari, María de Los Ángeles Vizcaya, Hanns Lembach, Roslye Berrios-Rojas, Felipe Melo-González, Mariana Ríos, Alexis M Kalergis, Susan M Bueno, Bruno Nervi

Journal: Clin Infect Dis

PubMed ID: 35255140

Doi: 10.1093/cid/ciac167

Products & Services: Recombinant Proteins

Influences of miR-378a-3p on the Pathogenesis of Allergic Rhinitis via GzmB-Mediated Inflammatory Reaction

Authors: Xuping Wang, Haiqing Zhang, Long Du, Lian Zhang

Journal: Evid Based Complement Alternat Med

PubMed ID: 36072399

Doi: 10.1155/2022/5926834

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Trafficking of NMDA receptors is essential for hippocampal synaptic plasticity and memory consolidation

Authors: Xin Yang, Ru Gong, Linwei Qin, Yifei Bao, Yi Fu, Shan Gao, Hui Yang, Jinfei Ni, Ti-Fei Yuan, Wei Lu

Journal: Cell Rep

PubMed ID: 35977502

Doi: 10.1016/j.celrep.2022.111217

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Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells

Authors: Yahui Wang, Ethan Stancliffe, Ronald Fowle-Grider, Rencheng Wang, Cheng Wang, Michaela Schwaiger-Haber, Leah P Shriver, Gary J Patti

Journal: Mol Cell

PubMed ID: 35973426

Doi: 10.1016/j.molcel.2022.07.007

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Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2

Authors: Jun Lan, Peng Chen, Weiming Liu, Wenlin Ren, Linqi Zhang, Qiang Ding, Qi Zhang, Xinquan Wang, Jiwan Ge

Journal: Structure

PubMed ID: 35917815

Doi: 10.1016/j.str.2022.07.005

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High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails

Authors: Brian R Shy, Vivasvan S Vykunta, Alvin Ha, Alexis Talbot, Theodore L Roth, David N Nguyen, Wolfgang G Pfeifer, Yan Yi Chen, Franziska Blaeschke, Eric Shifrut, Shane Vedova, Murad R Mamedov, Jing-Yi Jing Chung, Hong Li, Ruby Yu, David Wu, Jeffrey Wolf, Thomas G Martin, Carlos E Castro, Lumeng Ye, Jonathan H Esensten, Justin Eyquem, Alexander Marson

Journal: Nat Biotechnol

PubMed ID: 36008610

Doi: 10.1038/s41587-022-01418-8

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Novel antiinflammatory biologics shaped by parasite-host coevolution

Authors: Stephanie M Ryan, Roland Ruscher, Wayne A Johnston, Darren A Pickering, Malcolm W Kennedy, Brian O Smith, Linda Jones, Geraldine Buitrago, Matt A Field, Adrian J Esterman, Connor P McHugh, Daniel J Browne, Martha M Cooper, Rachael Y M Ryan, Denise L Doolan, Christian R Engwerda, Kim Miles, Makedonka Mitreva, John Croese, Tony Rahman, Kirill Alexandrov, Paul R Giacomin, Alex Loukas

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36037362

Doi: 10.1073/pnas.2202795119

Products & Services: Mammalian Expression

Expedient Synthesis of Ubiquitin-like Protein ISG15 Tools Through Chemo-Enzymatic Ligation Catalyzed by a Viral Protease Lbpro

Authors: Tian Wang , Chuntong Li , Meijing Wang , Jiachen Zhang , Qingyun Zheng , Lujun Liang , Guochao Chu , Xiaolin Tian , Haiteng Deng , Wei He , Lei Liu , Jinghong Li

Journal: Angew Chem Int Ed Engl

PubMed ID: 35962463

Doi: 10.1002/anie.202206205

Products & Services: Gene Synthesis

Enhancing the Catalytic Activity of Type II L-Asparaginase from Bacillus licheniformis through Semi-Rational Design

Authors: Yawen Zhou ,Linshu Jiao ,Juan Shen ,Huibing Chi ,Zhaoxin Lu ,Huawei Liu ,Fengxia Lu ,Ping Zhu

Journal: Int J Mol Sci

Doi: 10.3390/ijms23179663

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Dry powder inhalation technology for heart targeting applied to calcium phosphate nanoparticles loaded with active substances

Authors: Eride Quarta,Lorenzo Degli Esposti, Ruggero Bettini ,Fabio Sonvico ,Daniele Catalucci , Michele Iafisco ,Claudio De Luca ,Giovanna Trevisi ,Paolo Colombo ,Alessandra Rossi ,Francesca Buttini , Gaia Colombo

Journal: Drug Delivery Science and Technology

Doi: doi.org/10.1016/j.jddst.2022.103719

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Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides

Authors: Nayeli Escudero Castelán , Dean C Semmens , Luis Alfonso Yañez Guerra , Meet Zandawala , Mario Dos Reis , Susan E Slade , James H Scrivens , Cleidiane G Zampronio , Alexandra M Jones , Olivier Mirabeau , Maurice R Elphick

Journal: BMC Biol

PubMed ID: 36002813

Doi: 10.1186/s12915-022-01387-z

Products & Services: Gene Synthesis

The neurodevelopmental gene MSANTD2 belongs to a gene family formed by recurrent molecular domestication of Harbinger transposons at the base of vertebrates

Authors: Ema Etchegaray, Dominique Baas, Magali Naville, Zofia Haftek-Terreau, Jean Nicolas Volff

Journal: Mol Biol Evol

PubMed ID: 35980103

Doi: 10.1093/molbev/msac173

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Transient Complexity of Lipidome Is Explained by Fatty Acyl Synthesis and Cyclopropanation

Authors: Nikolay V Berezhnoy, Amaury Cazenave-Gassiot, Liang Gao, Juat Chin Foo, Shanshan Ji, Viduthalai Rasheedkhan Regina, Pui Khee Peggy Yap, Markus R Wenk, Staffan Kjelleberg, Thomas William Seviour, Jamie Hinks

Journal: Metabolites

PubMed ID: 36144187

Doi: 10.3390/metabo12090784

Products & Services: Bacterial Expression

The Biosynthesis of 1-octene-3-ol by a Multifunctional Fatty Acid Dioxygenase and Hydroperoxide Lyase in

Authors: Tongfu Su, Yuannan Chen, Haohao Liu, Yuqian Gao, Jiawen Guo, Yanan Li, Yuancheng Qi, Liyou Qiu

Journal: J Fungi (Basel)

PubMed ID: 36012815

Doi: 10.3390/jof8080827

Products & Services: Protein and Antibody Isolation

Human Claudin-Derived Peptides Block the Membrane Fusion Process of Zika Virus and Are Broad Flavivirus Inhibitors

Authors: Jim Zoladek, Julien Burlaud-Gaillard, Maxime Chazal, Sophie Desgraupes, Patricia Jeannin, Antoine Gessain, Nathalie Pardigon, Mathieu Hubert, Philippe Roingeard, Nolwenn Jouvenet, Philippe V Afonso

Journal: Microbiol Spectr

PubMed ID: 36040168

Doi: 10.1128/spectrum.02989-22

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TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

Authors: Wendy Wing Sze Yue, Lin Yuan, Joao M Braz, Allan I Basbaum, David Julius

Journal: Elife

PubMed ID: 35968676

Doi: 10.7554/eLife.80139

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Secretion of collagenases by Saccharomyces cerevisiae for collagen degradation

Authors: Han Xiao, Xiufang Liu, Yunzi Feng, Lin Zheng, Mouming Zhao, Mingtao Huang

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 36031598

Doi: 10.1186/s13068-022-02186-y

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Preferential binding of DAP-PGs by major peptidoglycan recognition proteins found in cell-free hemolymph of Manduca sexta

Authors: Udeshika Kariyawasam, Mansi Gulati, Yang Wang, Haibo Bao, Tisheng Shan, Xiuru Li, Xiaolong Cao, Niranji Sumathipala, Yingxia Hu, Xiufeng Zhang, Geert-Jan Boons, Haobo Jiang

Journal: Insect Biochem Mol Biol

PubMed ID: 36007680

Doi: 10.1016/j.ibmb.2022.103827

Products & Services: Monoclonal Antibody Services

Development and application of a rapid all-in-one plasmid CRISPR-Cas9 system for iterative genome editing in Bacillus subtilis

Authors: Yu Zou, Lu Qiu, Aowen Xie, Wenyuan Han, Shangbo Zhang, Jinshan Li, Shumiao Zhao, Yingjun Li, Yunxiang Liang, Yongmei Hu

Journal: Microb Cell Fact

PubMed ID: 35999638

Doi: 10.1186/s12934-022-01896-0

Products & Services: Gene Fragments

N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products

Authors: Kyusik Q Kim, Bhagyashri D Burgute, Shin-Cheng Tzeng, Crystal Jing, Courtney Jungers, Junya Zhang, Liewei L Yan, Richard D Vierstra, Sergej Djuranovic, Bradley S Evans, Hani S Zaher

Journal: Cell Rep

PubMed ID: 35988540

Doi: 10.1016/j.celrep.2022.111300

Products & Services: Plasmid DNA Preparation

Myoglobin diet affected the colonic mucus layer and barrier by increasing the abundance of several beneficial gut bacteria

Authors: Shuai Jiang, Dejiang Xue, Miao Zhang, Qian Li, Hui Liu, Di Zhao, Guanghong Zhou, Chunbao Li

Journal: Food Funct

PubMed ID: 35943300

Doi: 10.1039/d2fo01799g

Products & Services: Protein and Antibody Isolation

Microfluidic-Derived Detection of Protein-Facilitated Copper Flux Across Lipid Membranes

Authors: Kamil Górecki, Jesper S Hansen, Ping Li, Niloofar Nayeri, Karin Lindkvist-Petersson, Pontus Gourdon

Journal: Anal Chem

PubMed ID: 35969432

Doi: 10.1021/acs.analchem.2c02081

Products & Services: Bacterial Expression

Reduced sister chromatid cohesion acts as a tumor penetrance modifier

Authors: Jun Wang, Holly R Thomas, Yu Chen, Stefanie M Percival, Stephanie C Waldrep, Ryne C Ramaker, Robert G Thompson, Sara J Cooper, Zechen Chong, John M Parant

Journal: PLoS Genet

PubMed ID: 35994499

Doi: 10.1371/journal.pgen.1010341

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Novel Hits for N-Myristoyltransferase Inhibition Discovered by Docking-Based Screening

Authors: Danislav S Spassov, Mariyana Atanasova, Irini Doytchinova

Journal: Molecules

PubMed ID: 36080246

Doi: 10.3390/molecules27175478

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An antibody from single human V-rearranging mouse neutralizes all SARS-CoV-2 variants through BA5 by inhibiting membrane fusion

Authors: Sai Luo, Jun Zhang, Alex J B Kreutzberger, Amanda Eaton, Robert J Edwards, Changbin Jing, Hai-Qiang Dai, Gregory D Sempowski, Kenneth Cronin, Robert Parks, Adam Yongxin Ye, Katayoun Mansouri, Maggie Barr, Novalia Pishesha, Aimee Chapdelaine Williams, Lucas Vieira Francisco, Anand Saminathan, Hanqin Peng, Himanshu Batra, Lorenza Bellusci, Surender Khurana, S Munir Alam, David C Montefiori, Kevin O Saunders, Ming Tian, Hidde Ploegh, Tom Kirchhausen, Bing Chen, Barton F Haynes, Frederick W Alt

Journal: Sci Immunol

PubMed ID: 35951767

Doi: 10.1126/sciimmunol.add5446

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Salvianolic acid B activates chondrocytes autophagy and reduces chondrocyte apoptosis in obese mice via the KCNQ1OT1/miR-128-3p/SIRT1 signaling pathways

Authors: Tianwen Sun, Fei Wang, Gaojian Hu, Zhizhou Li

Journal: Nutr Metab (Lond)

PubMed ID: 35922815

Doi: 10.1186/s12986-022-00686-0

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High-titre production of aromatic amines in metabolically engineered Escherichia coli

Authors: Taiwei Yang, Peiling Wu, Yang Zhang, Mingfeng Cao, Jifeng Yuan

Journal: J Appl Microbiol

PubMed ID: 35938518

Doi: 10.1111/jam.15745

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Molecular Events behind the Selectivity and Inactivation Properties of Model NaK-Derived Ion Channels

Authors: Ana Marcela Giudici, María Lourdes Renart, Ana Coutinho, Andrés Morales, José Manuel González-Ros, José Antonio Poveda

Journal: Int J Mol Sci

PubMed ID: 36012519

Doi: 10.3390/ijms23169246

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Biliverdin incorporation into the cyanobacteriochrome SPI1085g3 from

Authors: Xian-Jun Wu, Jia-Ying Qu, Chang-Tian Wang, Ya-Ping Zhang, Ping-Ping Li

Journal: Front Microbiol

PubMed ID: 35983329

Doi: 10.3389/fmicb.2022.952678

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Structures of topoisomerase V in complex with DNA reveal unusual DNA-binding mode and novel relaxation mechanism

Authors: Amy Osterman, Alfonso Mondragón

Journal: Elife

PubMed ID: 35969036

Doi: 10.7554/eLife.72702

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The Catalytic Subunit of CK2 (Cka1) Negatively Regulates RNA Polymerase II Transcription through Phosphorylation of Positive Cofactor 4 (PC4)

Authors: Diego A Rojas, Fabiola Urbina, Aldo Solari, Edio Maldonado

Journal: Int J Mol Sci

PubMed ID: 36012759

Doi: 10.3390/ijms23169499

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Transcriptional changes in LMH cells induced by rhoptry kinase family protein 17

Authors: Yi-Jing Meng, Bing-Jin Mu, Xiao-Xin Liu, Lin-Mei Yu, Wen-Bin Zheng, Shi-Chen Xie, Wen-Wei Gao, Xing-Quan Zhu, Qing Liu

Journal: Front Vet Sci

PubMed ID: 36016802

Doi: 10.3389/fvets.2022.956040

Products & Services: Protein and Antibody Isolation

Structural basis for receptor selectivity and inverse agonism in S1P receptors

Authors: Elizaveta Lyapina, Egor Marin, Anastasiia Gusach, Philipp Orekhov, Andrey Gerasimov, Aleksandra Luginina, Daniil Vakhrameev, Margarita Ergasheva, Margarita Kovaleva, Georgii Khusainov, Polina Khorn, Mikhail Shevtsov, Kirill Kovalev, Sergey Bukhdruker, Ivan Okhrimenko, Petr Popov, Hao Hu, Uwe Weierstall, Wei Liu, Yunje Cho, Ivan Gushchin, Andrey Rogachev, Gleb Bourenkov, Sehan Park, Gisu Park, Hyo Jung Hyun, Jaehyun Park, Valentin Gordeliy, Valentin Borshchevskiy, Alexey Mishin, Vadim Cherezov

Journal: Nat Commun

PubMed ID: 35961984

Doi: 10.1038/s41467-022-32447-1

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Strong T-cell activation in response to COVID-19 vaccination in multiple sclerosis patients receiving B-cell depleting therapies

Authors: Roberto Alfonso-Dunn, Jerry Lin, Vanessa Kirschner, Joyce Lei, Grant Feuer, Michaela Malin, Jiayuan Liu, Morgan Roche, Saud A Sadiq

Journal: Front Immunol

PubMed ID: 35990701

Doi: 10.3389/fimmu.2022.926318

CpG content in the Zika virus genome affects infection phenotypes in the adult brain and fetal lymph nodes

Authors: Daniel Udenze, Ivan Trus, Nathalie Berube, Uladzimir Karniychuk

Journal: Front Immunol

PubMed ID: 35983032

Doi: 10.3389/fimmu.2022.943481

Products & Services: Gene Fragments

Manipulation of peptide-fatty acid bioconjugates on graphene: effects of fatty acid chain length and attachment point

Authors: Yuliana Perdomo, Ruitao Jin, Atul D Parab, Marc R Knecht, Tiffany R Walsh

Journal: J Mater Chem B

PubMed ID: 35894139

Doi: 10.1039/d2tb01104b

Products & Services: Protein and Antibody Isolation

Dual peptide-functionalized hydrogels differentially control periodontal cell function and promote tissue regeneration

Authors: David Fraser, Danielle Benoit

Journal: Biomater Adv

PubMed ID: 36067642

Doi: 10.1016/j.bioadv.2022.213093

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Engineering an adenine base editor in human embryonic stem cells with minimal DNA and RNA off-target activities

Authors: Zhenwu Zhang, Wanyu Tao, Shisheng Huang, Wenjun Sun, Yue Wang, Wen Jiang, Xingxu Huang, Chao-Po Lin

Journal: Mol Ther Nucleic Acids

PubMed ID: 35991312

Doi: 10.1016/j.omtn.2022.07.026

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Immunogenicity and Protective Efficacy of a Recombinant Pichinde Viral-Vectored Vaccine Expressing Influenza Virus Hemagglutinin Antigen in Pigs

Authors: Sushmita Kumari, Jayeshbhai Chaudhari, Qinfeng Huang, Phillip Gauger, Marcelo Nunes De Almeida, Yuying Liang, Hinh Ly, Hiep L X Vu

Journal: Vaccines (Basel)

PubMed ID: 36146478

Doi: 10.3390/vaccines10091400

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Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure

Authors: Eva K Oernbo, Annette B Steffensen, Pooya Razzaghi Khamesi, Trine L Toft-Bertelsen, Dagne Barbuskaite, Frederik Vilhardt, Niklas J Gerkau, Katerina Tritsaris, Anja H Simonsen, Sara D Lolansen, Søren N Andreassen, Steen G Hasselbalch, Thomas Zeuthen, Christine R Rose, Vartan Kurtcuoglu, Nanna MacAulay

Journal: Fluids Barriers CNS

PubMed ID: 36038945

Doi: 10.1186/s12987-022-00358-4

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MTP18 inhibition triggers mitochondrial hyperfusion to induce apoptosis through ROS-mediated lysosomal membrane permeabilization-dependent pathway in oral cancer

Authors: Debasna Pritimanjari Panigrahi, Srimanta Patra, Bishnu Prasad Behera, Pradyota Kumar Behera, Shankargouda Patil, Birija Sankar Patro, Laxmidhar Rout, Itisam Sarangi, Sujit Kumar Bhutia

Journal: Free Radic Biol Med

PubMed ID: 35985563

Doi: 10.1016/j.freeradbiomed.2022.08.019

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A Rapid Translational Immune Response Program in CD8 Memory T Lymphocytes

Authors: Darin Salloum, Kamini Singh, Natalie R Davidson, Linlin Cao, David Kuo, Viraj R Sanghvi, Man Jiang, Maria Tello Lafoz, Agnes Viale, Gunnar Ratsch, Hans-Guido Wendel

Journal: J Immunol

PubMed ID: 36002234

Doi: 10.4049/jimmunol.2100537

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Effects of boosted mRNA and adenoviral-vectored vaccines on immune responses to omicron BA1 and BA2 following the heterologous CoronaVac/AZD1222 vaccination

Authors: Nungruthai Suntronwong, Sitthichai Kanokudom, Chompoonut Auphimai, Suvichada Assawakosri, Thanunrat Thongmee, Preeyaporn Vichaiwattana, Thaneeya Duangchinda, Warangkana Chantima, Pattarakul Pakchotanon, Jira Chansaenroj, Jiratchaya Puenpa, Pornjarim Nilyanimit, Donchida Srimuan, Thaksaporn Thatsanatorn, Natthinee Sudhinaraset, Nasamon Wanlapakorn, Juthathip Mongkolsapaya, Yong Poovorawan

Journal: J Med Virol

PubMed ID: 35924475

Doi: 10.1002/jmv.28044

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The antibody landscapes following AS03 and MF59 adjuvanted H5N1 vaccination

Authors: Johannes B Goll, Aarti Jain, Travis L Jensen, Rafael Assis, Rie Nakajima, Algis Jasinskas, Lynda Coughlan, Sami R Cherikh, Casey E Gelber, S Khan, D Huw Davies, Philip Meade, Daniel Stadlbauer, Shirin Strohmeier, Florian Krammer, Wilbur H Chen, Philip L Felgner

Journal: npj Vaccines

PubMed ID: 36042229

Doi: 10.1038/s41541-022-00524-7

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A cytoskeletal vortex drives phage nucleus rotation during jumbo phage replication in E coli

Authors: Erica A Birkholz, Thomas G Laughlin, Emily Armbruster, Sergey Suslov, Jina Lee, Johannes Wittmann, Kevin D Corbett, Elizabeth Villa, Joe Pogliano

Journal: Cell Rep

PubMed ID: 35977483

Doi: 10.1016/j.celrep.2022.111179

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Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport

Authors: Xiaopan Gao, Huabin Tian, Kaixiang Zhu, Qing Li, Wei Hao, Linyue Wang, Bo Qin, Hongyu Deng, Sheng Cui

Journal: Nat Commun

PubMed ID: 35970938

Doi: 10.1038/s41467-022-32489-5

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EmCyclinD-EmCDK4/6 complex is involved in the host EGF-mediated proliferation of germinative cells the EGFR-ERK pathway

Authors: Chonglv Feng, Zhe Cheng, Zhijian Xu, Ye Tian, Huimin Tian, Fan Liu, Damin Luo, Yanhai Wang

Journal: Front Microbiol

PubMed ID: 36033888

Doi: 10.3389/fmicb.2022.968872

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A context-dependent and disordered ubiquitin-binding motif

Authors: Jesper E Dreier, Andreas Prestel, João M Martins, Sebastian S Brøndum, Olaf Nielsen, Anna E Garbers, Hiroaki Suga, Wouter Boomsma, Joseph M Rogers, Rasmus Hartmann-Petersen, Birthe B Kragelund

Journal: Cell Mol Life Sci

PubMed ID: 35974206

Doi: 10.1007/s00018-022-04486-w

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