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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI

Authors: Benjamin Bourgeois, Emil Spreitzer, Daniel Platero-Rochart, Margret Paar, Qishun Zhou, Sinem Usluer, Peter L J de Keizer, Boudewijn M T Burgering, Pedro A Sánchez-Murcia, Tobias Madl

Journal: Nature Communications

PubMed ID: 40593617

Doi: 10.1038/s41467-025-60844-9

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Pericyte pannexin1 controls cerebral capillary diameter and supports memory function

Authors: Sandra Mai-Morente, Eugenia Isasi, Alberto Rafael, Gonzalo Budelli, Silvia Olivera-Bravo, Nathalia Vitureira, Verónica Abudara

Journal: Nature Communications

PubMed ID: 40610448

Doi: 10.1038/s41467-025-61312-0

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Oropouche virus infects human trophoblasts and placenta explants

Authors: Christina J Megli, Rebecca K Zack, Jackson J McGaughey, Ryan M Hoehl, Taylor Snisky, Amy L Hartman, Cynthia M McMillen

Journal: Nature Communications

PubMed ID: 40593852

Doi: 10.1038/s41467-025-61138-w

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An adaptive peptide-binding site in ubiquitin receptor hRpn13 revealed by structural studies

Authors: Bakar Hassan, Monika Chandravanshi, Martin Y Ng, Hitendra Negi, Brice A P Wilson, Kylie J Walters

Journal: Nature Communications

PubMed ID: 40595513

Doi: 10.1038/s41467-025-60843-w

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Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors

Authors: Kevin Sek, Amanda X Y Chen, Thomas Cole, Jesse D Armitage, Junming Tong, Kah Min Yap, Isabelle Munoz, Phoebe A Dunbar, Shiyi Wu, Marit J van Elsas, Olivia Hidajat, Christina Scheffler, Lauren Giuffrida, Melissa A Henderson, Deborah Meyran, Fernando Souza-Fonseca-Guimaraes, Dat Nguyen, Yu-Kuan Huang, Maria N de Menezes, Emily B Derrick, Cheok Weng Chan, Kirsten L Todd, Jack D Chan, Jasmine Li, Junyun Lai, Emma V Petley, Sherly Mardiana, Anthony Bosco, Jason Waithman, Ian A Parish, Christina Mølck, Gregory D Stewart, Lev Kats, Imran G House, Phillip K Darcy, Paul A Beavis

Journal: Nature Communications

PubMed ID: 40610421

Doi: 10.1038/s41467-025-59021-9

Single-cell RNA sequencing and PANDORA-seq reveal the pivotal role of piRNA in heat stress-induced testicular injury

Authors: Mailin Gan, Jianfeng Ma, Yuhang Lei, Yiting Yang, Yuheng Pan, Shuang Wu, Siyu Chen, Jiaxin Li, Linyuan Shen, Li Zhu

Journal: International Journal of Biological Macromolecules

PubMed ID: 40609925

Doi: 10.1016/j.ijbiomac.2025.145674

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A novel and sensitive AuNPs/tetracystein-glucose dehydrogenase(GDH)/ screen-printed electrode(SPE)-based electrochemical glucose biosensor

Authors: Ting Zhang , Danni Ma , Fuman Cai

Journal: Microchemical Journal

Doi: doi.org/10.1016/j.microc.2025.114629

Products & Services: Codon Optimization Gene Synthesis Molecular Biology Reagents

Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation

Authors: Rajamanikkam Kamaraj, Ivana Mejdrová, Maria Krutakova, Tomas Smutny, Kryštof Škach, Klara Dohnalova, Lucie Smutna, Dharani Sai Sreekanth Nellore, Jan Dusek, Karel Chalupsky, Jana Hricová, Thales Kronenberger, Aaron Stahl, Markus Templin, Albert Braeuning, Radim Nencka, Petr Pavek

Journal: Journal of Medicinal Chemistry

PubMed ID: 40650588

Doi: 10.1021/acs.jmedchem.4c03134

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Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma

Authors: Bartimée Galvan, Loïc Ongena, Jonathan Bruyr, Gregory Fettweis, Eva Lucarelli, Arnaud Lavergne, Emeline Mariavelle, Tina M O'Grady, Zahrat El Oula Hassoun, Margaux Claes, Laurence Dubois, Kevin A W Lee, Véronique Kruys, Cyril Gueydan, Jules Durand, Eric Hervouet, Florian H Geyer, Ana Banito, Roland Imle, Lianghao Mao, Ashok K Jayavelu, Thomas G P Grünewald, Florencia Cidre-Aranaz, Jean-Claude Twizere, Franck Dequiedt

Journal: Nature Communications

PubMed ID: 40664627

Doi: 10.1038/s41467-025-61725-x

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Mice with a diverse human T cell receptor repertoire selected on multiple HLA class I molecules

Authors: Arunraj Dhamodaran, Xiaojing Chen, Niklas Fellmer, Deepti Agrawal, Eric Danner, Ralf Kühn, Thomas Blankenstein

Journal: Nature Communications

PubMed ID: 40593800

Doi: 10.1038/s41467-025-61306-y

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A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma

Authors: Christophe-Sébastien Arnold, Anna-Maria Alazzi, Serena Shunmugam, Jan Janouškovec, Laurence Berry, Sarah Charital, Thierry Gautier, Samuel Duley, Delphine Jublot, Catherine Lemaire-Vieille, Marie-France Cesbron-Delauw, Pierre Cavailles, Jérôme Govin, Nicholas J Katris, Yoshiki Yamaryo-Botté, Cyrille Y Botté

Journal: Nature Communications

PubMed ID: 40595705

Doi: 10.1038/s41467-025-61155-9

Structural-functional characterization of the MIRO1-TRAK1 complex

Authors: Erika E Ravitch, Elana E Baltrusaitis, Tania A Perez, Kyle R Barrie, Adam R Fenton, Erika L F Holzbaur, Roberto Dominguez

Journal: Nature Communications

PubMed ID: 40615373

Doi: 10.1038/s41467-025-61174-6

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Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes

Authors: Markéta Novotná, Michele Tinti, Joana R C Faria, David Horn

Journal: Nature Communications

PubMed ID: 40615444

Doi: 10.1038/s41467-025-61480-z

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Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail

Authors: J Atherton, M S Chegkazi, M Leusciatti, M Di Palma, E Peirano, L S Pozzer, M V A Meli, S Pasqualato, T Foran, G Morra, R A Steiner

Journal: Nature Communications

PubMed ID: 40617823

Doi: 10.1038/s41467-025-61498-3

Products & Services: Mammalian Expression

Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy

Authors: Meijun Si, Jingpeng Fu, Mengting Fang, Yunfei Lu, Junxuan Huang, Haojie Li, Peiyi Wang, Maofu Liao, Jian Zhu, Peiyao Li, Wenzhao Zhong, Zhifei Guo, Wei Yang, Zhiming Ye, Hongli Hu, Xueqing Yu

Journal: Nature Communications

PubMed ID: 40593574

Doi: 10.1038/s41467-025-60819-w

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Myosin-dependent short actin filaments contribute to peripheral widening in developing stereocilia

Authors: Xiayi Liao, Chun-Yu Tung, Jocelyn F Krey, Ghazaleh Behnammanesh, Joseph A Cirilo Jr, Mert Colpan, Christopher M Yengo, Peter G Barr-Gillespie, Jonathan E Bird, Benjamin J Perrin

Journal: Nature Communications

PubMed ID: 40593742

Doi: 10.1038/s41467-025-60976-y

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Continuous in situ synthesis of a complete set of tRNAs sustains steady-state translation in a recombinant cell-free system

Authors: Fanjun Li , Amogh Kumar Baranwal , Sebastian J Maerkl

Journal: Nature Communications

PubMed ID: 40617857

Doi: 10.1038/s41467-025-61671-8

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Pol θ-mediated end-joining uses microhomologies containing mismatches

Authors: Yuzhen Li, Ngoc K Dang, Wei He, Mark Returan, Denisse Carvajal-Maldonado, Adele T Guerin, Han Xu, Bin Liu, Richard D Wood

Journal: Nature Communications

PubMed ID: 40603872

Doi: 10.1038/s41467-025-61258-3

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FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses

Authors: Choah Kim, Katlyn R Gabriel, Dylan Boone, Matthew R Brown, Katherine Oppenheimer, Maria Kost-Alimova, Juan Lorenzo B Pablo, Anna Greka

Journal: SCIENCE ADVANCES

PubMed ID: 40601736

Doi: 10.1126/sciadv.adu9104

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Rim4-seeded stress granules connect temperature sensing to meiotic regulation

Authors: Rudian Zhang, Shunjin Li, Wenzhi Feng, Suhong Qian, Akshay John Chellappa, Fei Wang

Journal: Nature Communications

PubMed ID: 40593583

Doi: 10.1038/s41467-025-60645-0

Products & Services: Protein Electrophoresis and Western

Engineered Nano-micro Pyroptosis Generators: A Magnetic-Metallo-Immunotherapeutic Strategy to Reinforce Transarterial Embolization

Authors: Di Wang, Linzhu Zhang, Jihu Nie, Nailin Yang, Shumin Sun, Chunjie Wang, Zifan Pei, Fei Gong, Xingwei Sun, Yong Jin, Liang Cheng

Journal: Journal of the American Chemical Society

PubMed ID: 40644662

Doi: 10.1021/jacs.5c06039

β-catenin functions as a molecular adapter for disordered cBAF interactions

Authors: Yuen San Chan, Qinyu Gao, Sarah A Robinson, Wenzhi Wang, Ruzena Filandrova, Lisa-Maria Weinhold, Mario Loeza Cabrera, Miao Zhang, Chandra Shekar R Ambati, Antonio M Lerario, Nagireddy Putluri, Katja Kiseljak-Vassiliades, Margaret E Wierman, Mouhammed Amir Habra, Gary D Hammer, Vaclav Veverka, Katerina Cermakova, H Courtney Hodges

Journal: Molecular Cell

PubMed ID: 40695292

Products & Services: Recombinant Proteins

Formation and centromere inactivation of fusion chromosomes in two allotetraploid species from the Saccharum complex

Authors: Zehuai Yu, Yongji Huang, Xikai Yu, Zuhu Deng, Jin Chai, Jiarui Liu, Zhiyun Gong, Wei Yao, Jisen Zhang, Muqing Zhang, Fan Yu, Jiming Jiang

Journal: New Phytologist

PubMed ID: 40726300

Doi: 10.1111/nph.70369

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Therapeutic circRNA aptamer alleviates PKR-associated osteoarthritis

Authors: Si-Kun Guo, Jinlong Suo, Youkui Huang, Xubin Yin, Jinghui Wang, Ling Li, Shaokun Sun, Weiguo Zou, Ling-Ling Chen

Journal: Science Bulletin

PubMed ID: 40021383

Doi: 10.1016/j.scib.2025.02.027

Whole-genome identification, evolutionary decipherment, and expression profiling analyses of alcohol dehydrogenase family members in soybean (Glycine max (L.) Merr.)

Authors: Liang Wang, Jing Wang, Xianqin Wen, Wenhua Dongchen, Yumei Dong, Yuanyuan Li, Quan Liang, Yaqiong Zhang

Journal: Plant Stress

Doi: 10.1016/j.stress.2025.100975

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Modifying recombinant purple acid phosphatase using computational design

Authors: Aishwarya Venkatramani, Montader Ali, Olga Predeina, Jennifer C Molloy, Pietro Sormanni, Elizabeth A H Hall

Journal: European Biophysics Journal

PubMed ID: 40650743

Doi: 10.1007/s00249-025-01779-3

Products & Services: Protein and Antibody Isolation

NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis

Authors: Ann-Kristin Dicke, Ammar Ahmedani, Lin Ma, Leonie Herrmann, Godfried W van der Heijden, Sophie A Koser, Claudia Krallmann, Oguzhan Kalyon, Miguel J Xavier, Joris A Veltman, Sabine Kliesch, Nina Neuhaus, Noora Kotaja, Frank Tüttelmann, Birgit Stallmeyer

Journal: Nature Communications

PubMed ID: 40624043

Doi: 10.1038/s41467-025-61463-0

Products & Services: PCR Cloning and Subcloning

A single main-chain hydrogen bond required to keep GABAA receptors closed

Authors: Cecilia M Borghese, Jason D Galpin, Samuel Eriksson Lidbrink, Yuxuan Zhuang, Netrang G Desai, Rebecca J Howard, Erik Lindahl, Christopher A Ahern, Marcel P Goldschen-Ohm

Journal: Nature Communications

PubMed ID: 40603861

Doi: 10.1038/s41467-025-61447-0

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Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses

Authors: Arne Matthys, Jan Felix, Joao Paulo Portela Catani, Kenny Roose, Wim Nerinckx, Benthe Van Buyten, Daria Fijalkowska, Nico Callewaert, Savvas N Savvides, Xavier Saelens

Journal: Nature Communications

PubMed ID: 40593518

Doi: 10.1038/s41467-025-60232-3

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Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery

Authors: Amanda X Y Chen, Kah Min Yap, Joelle S Kim, Kevin Sek, Yu-Kuan Huang, Phoebe A Dunbar, Volker Wiebking, Jesse D Armitage, Isabelle Munoz, Kirsten L Todd, Emily B Derrick, Dat Nguyen, Junming Tong, Cheok Weng Chan, Thang X Hoang, Katherine M Audsley, Marit J van Elsas, Jim Middelburg, Joel N Lee, Maria N de Menezes, Thomas J Cole, Jasmine Li, Christina Scheffler, Andrew M Scott, Laura K Mackay, Jason Waithman, Jane Oliaro, Simon J Harrison, Ian A Parish, Junyun Lai, Matthew H Porteus, Imran G House, Phillip K Darcy, Paul A Beavis

Journal: Nature

PubMed ID: 40604285

Doi: 10.1038/s41586-025-09212-7

Products & Services: PCR Cloning and Subcloning

Molecular architecture and catalytic mechanism of human glycogen debranching enzyme

Authors: Huiyi Guan, Huan Chen, He Geng, Ruifang Ma, Zhongmin Liu, Yong Wang, Yifang Chen, Kaige Yan

Journal: Nature Communications

PubMed ID: 40593796

Doi: 10.1038/s41467-025-61077-6

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Visualization of a multi-turnover Cas9 after product release

Authors: Kaitlyn A. Kiernan & David W. Taylor

Journal: Nature Communications

PubMed ID: 40593576

Doi: 10.1038/s41467-025-60668-7

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Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ

Authors: K S Beckwith, Ø Ødegård-Fougner, N R Morero, C Barton, F Schueder, W Tang, S Alexander, J-M Peters, R Jungmann, E Birney, J Ellenberg

Journal: Nature Communications

PubMed ID: 40683887

Doi: 10.1038/s41467-025-61689-y

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Rationally Designed TadA-Derived Cytosine Editors Enable Context-Independent Zebrafish Genome Editing

Authors: Wei Qin, Sheng-Jia Lin, Yu Zhang, Kevin Huang, Cassidy Petree, Kevin Boyd, Pratishtha Varshney, Gaurav K Varshney

Journal: Advanced Science

PubMed ID: 40685751

Doi: 10.1002/advs.202509800

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Structural insights into the roles of PARP4 and NAD+ binding in the human vault cage

Authors: Jane E Lodwick, Rong Shen, Satchal Erramilli, Yuan Xie, Karolina Roganowicz, Simone Ritchey, Anthony A Kossiakoff, Minglei Zhao

Journal: Nature Communications

PubMed ID: 40691181

Doi: 10.1038/s41467-025-61981-x

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Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination

Authors: Jaigeeth Deveryshetty, Ayush Mistry, Sushil Pangeni, Mohamed Ghoneim, Monica Tokmina-Lukaszewska, Steven K Gore, Jie Liu, Vikas Kaushik, Simrithaa Karunakaran, Angela Taddei, Wolf-Dietrich Heyer, Taekjip Ha, Brian Bothner, Edwin Antony

Journal: Nature Communications

PubMed ID: 40691144

Doi: 10.1038/s41467-025-61811-0

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Human Schlafen 14 Cleavage of Short Double-Stranded RNAs Underpins its Antiviral Activity

Authors: Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui

Journal: Advanced Science

PubMed ID: 40642785

Doi: 10.1002/advs.202501727

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Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury

Authors: Zhiqiang Zhao, Xinzhu Shan, Jing Ding, Bin Ma, Buyao Li, Wendi Huang, Qingqing Yang, Yian Fang, Junhe Chen, Chenglin Song, Chenlong Wei, Shuai Liu, Xingdi Cheng, Shengran Zhang, Yunxuan Liu, Hongkun Wu, Cong Luo, Shaokun Shu, Xue Qiao, Zefeng Wang, Xueguang Lu, Lei Miao

Journal: Nature Communications

PubMed ID: 40659631

Doi: 10.1038/s41467-025-61688-z

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Adipose tissue-derived PRXL2A suppresses hepatic lipogenesis in a study with male mice

Authors: Zhiyuan Li, Zheng Tian, Xiaoliu Shi, Aijun Long, Yazhuo Wang, Yan Yang, Yaqi Wang, Jingjing Zhang, Yiguo Wang

Journal: Nature Communications

PubMed ID: 40670400

Doi: 10.1038/s41467-025-61963-z

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Deep-tissue high-sensitivity multimodal imaging and optogenetic manipulation enabled by biliverdin reductase knockout

Authors: Ludmila A Kasatkina, Chenshuo Ma, Huaxin Sheng, Matthew Lowerison, Luca Menozzi, Mikhail Baloban, Yuqi Tang, Yirui Xu, Lucas Humayun, Tri Vu, Pengfei Song, Junjie Yao, Vladislav V Verkhusha

Journal: Nature Communications

PubMed ID: 40659617

Doi: 10.1038/s41467-025-61532-4

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Ion channel structure and function of the MERS coronavirus E protein

Authors: Iva Sučec, Bingqing Xia, Noah H Somberg, Yi Wang, Hyunil Jo, Shuangqu Li, Barbara Perrone, Zhaobing Gao, Mei Hong

Journal: SCIENCE ADVANCES

PubMed ID: 40632851

Doi: 10.1126/sciadv.adx1788

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Supramolecular Lubricating Hydrogel Microspheres Reshape Damaged Matrix Regeneration

Authors: Hui Yuan 1, Pengcheng Xiao 2, Wei Huang 2, Wenguo Cui 1

Journal: Advanced Science

PubMed ID: 40667608

Doi: 10.1002/advs.202504319

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Nucleosome spacing can fine-tune higher-order chromatin assembly

Authors: Lifeng Chen, M Julia Maristany, Stephen E Farr, Jinyue Luo, Bryan A Gibson, Lynda K Doolittle, Jorge R Espinosa, Jan Huertas, Sy Redding, Rosana Collepardo-Guevara, Michael K Rosen

Journal: Nature Communications

PubMed ID: 40628730

Doi: 10.1038/s41467-025-61482-x

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A Complementarity-Based Approach to De Novo Binder Design

Authors: Kateryna Maksymenko, Valeriia Hatskovska, Murray Coles, Narges Aghaallaei, Natalia Pashkovskaia, Natalia Borbarán-Bravo, Matteo Pilz, Philip Bucher, Mareike Volz, Joana Pereira, Marcus D Hartmann, Ghazaleh Tabatabai, Judith Feucht, Stefan Liebau, Patrick Müller, Andrei N Lupas, Julia Skokowa, Mohammad ElGamacy

Journal: Advanced Science

PubMed ID: 40686280

Doi: 10.1002/advs.202502015

Products & Services: Protein and Antibody Isolation

Co‑treatment with triptolide and RSL3 induces hepatocellular carcinoma cell apoptosis and ferroptosis

Authors: Weixia Liu , Guodi Wu , Jing Wang , Shanshan Wu , Zhi Chen

Journal: Molecular Medicine Reports

PubMed ID: 40376993

Doi: 10.3892/mmr.2025.13567

Products & Services: Protein Electrophoresis and Western

The crystal structure of coronavirus RBD-TMPRSS2 complex provides basis for the discovery of therapeutic antibodies

Authors: Zhuoqian Zhao, Qi Yang, Xiaoce Liu, Mengfei Li, Yinkai Duan, Mingjuan Du, Anqi Zhou, Huanzhen Liu, Yujia He, Wei Wang, Yuchi Lu, Xiaoyu Zhang, Haofeng Wang, Xiuna Yang, Hongkai Zhang, Xinwen Chen, Zihe Rao, Haitao Yang

Journal: nature COMMUNICATION

PubMed ID: 40681508

Doi: 10.1038/s41467-025-62023-2

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Metabolic modulation-driven self-reinforcing pyroptosis-STING nanoadjuvant for potentiated metalloimmunotherapy

Authors: Linzhu Zhang, Di Wang, Yiming Liu, Nailin Yang, Shumin Sun, Chunjie Wang, Duo Wang, Jihu Nie, Juan Qin, Lei Zhang, Liang Cheng, Haidong Zhu

Journal: Bioactive Materials

PubMed ID: 40792115

Doi: 10.1016/j.bioactmat.2025.07.040

Products & Services: Protein and Antibody Isolation

Chromosome-specific oligo-painting provides insights into the cytogenetic basis of karyotypic stasis in paleo-allotetraploid Cucurbita

Authors: Qinzheng Zhao, Yulin Bai, Yuhui Wang, Chunyan Cheng, Xiaqing Yu, Qunfeng Lou, Jinfeng Chen