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TBC1D18 is a Rab5-GAP that coordinates endosome maturation together with Mon1

Authors: Shu Hiragi, Takahide Matsui, Yuriko Sakamaki, Mitsunori Fukuda

Journal: J Cell Biol

PubMed ID: 36197338

Doi: 10.1083/jcb.202201114

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The diurnal emission of floral scent in Oncidium hybrid orchid is controlled by CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) through the direct regulation on terpene synthase

Authors: Chao-Wei Yeh, Hui-Qin Zhong, Yung-Feng Ho, Zhi-Hong Tian, Kai-Wun Yeh

Journal: BMC Plant Biol

PubMed ID: 36195835

Doi: 10.1186/s12870-022-03850-z

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Highly efficient hybridoma generation and screening strategy for anti-PD-1 monoclonal antibody development

Authors: Tanapati Phakham, Chatikorn Boonkrai, Tossapon Wongtangprasert, Thittaya Audomsun, Chadaporn Attakitbancha, Pijitra Saelao, Phijitra Muanwien, Sarintip Sooksai, Nattiya Hirankarn, Trairak Pisitkun

Journal: Sci Rep

PubMed ID: 36273231

Doi: 10.1038/s41598-022-20560-6

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Proline-Rich Region II (PRR2) Plays an Important Role in Tau-Glycan Interaction: An NMR Study

Authors: Anqesha Murray, Lufeng Yan, James M Gibson, Jian Liu, David Eliezer, Guy Lippens, Fuming Zhang, Robert J Linhardt, Jing Zhao, Chunyu Wang

Journal: Biomolecules

PubMed ID: 36358923

Doi: 10.3390/biom12111573

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Durability of antibodies post vaccination with two doses of inactivated BBIBP-CorV vaccine

Authors: Sally Mahmoud, Subhashini Ganesan, Narjes Saheb Sharif-Askari, Flavia Cantarutti, Hannah Wilson, Pauline Ogrodzki, Rabih Halwani, Nawal Alkaabi, Walid Abbas Zaher

Journal: Curr Med Res Opin

PubMed ID: 36274640

Doi: 10.1080/03007995.2022.2139969

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The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation

Authors: Radwa E Mahgoub, Feda E Mohamed, Lara Alzyoud, Bassam R Ali, Juliana Ferreira, Wael M Rabeh, Shaikha S AlNeyadi, Noor Atatreh, Mohammad A Ghattas

Journal: Molecules

PubMed ID: 36235244

Doi: 10.3390/molecules27196710

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Quantum Dot-Based Screening Identifies F3 Peptide and Reveals Cell Surface Nucleolin as a Therapeutic Target for Rhabdomyosarcoma

Authors: Dzhangar Dzhumashev, Andrea Timpanaro, Safa Ali, Andrea J De Micheli, Kamel Mamchaoui, Ilaria Cascone, Jochen Rössler, Michele Bernasconi

Journal: Cancers (Basel)

PubMed ID: 36291832

Doi: 10.3390/cancers14205048

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Establishment of a protocol for preventive vaccination against equine insect bite hypersensitivity

Authors: Sara Bjork Stefansdottir, Sigridur Jonsdottir, Holmfridur Kristjansdottir, Vilhjalmur Svansson, Eliane Marti, Sigurbjorg Torsteinsdottir

Journal: Vet Immunol Immunopathol

PubMed ID: 36272211

Doi: 10.1016/j.vetimm.2022.110502

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Development and in vitro characterization of a humanized scFv against fungal infections

Authors: Tomas Di Mambro, Tania Vanzolini, Marzia Bianchi, Rita Crinelli, Barbara Canonico, Filippo Tasini, Michele Menotta, Mauro Magnani

Journal: PLoS ONE

PubMed ID: 36315567

Doi: 10.1371/journal.pone.0276786

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De novo design of anti-tuberculosis agents using a structure-based deep learning method

Authors: Sowmya Ramaswamy Krishnan, Navneet Bung, Siladitya Padhi, Gopalakrishnan Bulusu, Parimal Misra, Manojit Pal, Srinivas Oruganti, Rajgopal Srinivasan, Arijit Roy

Journal: J Mol Graph Model

PubMed ID: 36257148

Doi: 10.1016/j.jmgm.2022.108361

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Prostaglandin E synchronizes lunar-regulated beach spawning in grass puffers

Authors: Junfeng Chen, Yuma Katada, Kousuke Okimura, Taiki Yamaguchi, Ying-Jey Guh, Tomoya Nakayama, Michiyo Maruyama, Yuko Furukawa, Yusuke Nakane, Naoyuki Yamamoto, Yoshikatsu Sato, Hironori Ando, Asako Sugimura, Kazufumi Tabata, Ayato Sato, Takashi Yoshimura

Journal: Curr Biol

PubMed ID: 36306789

Doi: 10.1016/j.cub.2022.09.062

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Deciphering the virulence potential of Listeria monocytogenes in the Norwegian meat and salmon processing industry by combining whole genome sequencing and in vitro data

Authors: Eva Wagner, Annette Fagerlund, Sarah Thalguter, Merete Rusås Jensen, Even Heir, Trond Møretrø, Birgitte Moen, Solveig Langsrud, Kathrin Rychli

Journal: Int J Food Microbiol

PubMed ID: 36240603

Doi: 10.1016/j.ijfoodmicro.2022.109962

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Hydrogen-bonds mediate liquid-liquid phase separation of mussel derived adhesive peptides

Authors: Qi Guo, Guijin Zou, Xuliang Qian, Shujun Chen, Huajian Gao, Jing Yu

Journal: Nat Commun

PubMed ID: 36182948

Doi: 10.1038/s41467-022-33545-w

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An experimental test of the nicotinic hypothesis of COVID-19

Authors: Nicole E Godellas, Gisela D Cymes, Claudio Grosman

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36279466

Doi: 10.1073/pnas.2204242119

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Ultra-sensitive molecular detection of gene fusions from RNA using ASPYRE

Authors: Eleanor R Gray, Justyna M Mordaka, Efthimia R Christoforou, Kristine von Bargen, Nicola D Potts, Christina Xyrafaki, Ana-Luisa Silva, Magdalena Stolarek-Januszkiewicz, Katarzyna Anton, Paulina K Powalowska, Simonetta Andreazza, Alessandro Tomassini, Rebecca N Palmer, Aishling Cooke, Robert J Osborne, Barnaby W Balmforth

Journal: BMC Med Genomics

PubMed ID: 36224552

Doi: 10.1186/s12920-022-01363-0

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Long noncoding RNA-mediated activation of PROTOR1/PRR5-AKT signaling shunt downstream of PI3K in triple-negative breast cancer

Authors: Zhenbo Tu, Yi Hu, Devesh Raizada, Mahmoud A Bassal, Daniel G Tenen, Antoine E Karnoub

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36269860

Doi: 10.1073/pnas.2203180119

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AlphaFold version 20 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys-Cys) formation of functional significance for VIPR2

Authors: Kotaro Sakamoto, Satoshi Asano, Yukio Ago, Takatsugu Hirokawa

Journal: Biochem Biophys Res Commun

PubMed ID: 36332470

Doi: 10.1016/j.bbrc.2022.10.071

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Presence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies Among Vietnamese Healthcare Workers by Dosing Interval for ChAdOx1 nCoV-19 Vaccine

Authors: Dien M Vu, Diep T B Vu, Thuy T T Do, Allison E Olmsted, Bach H Dao, Truc T Thai, Chi L Nguyen, Nhung T T Le, Tuan A Le, Hien T T Bui, Thach N Pham, Matthew R Moore

Journal: Clin Infect Dis

PubMed ID: 35723271

Doi: 10.1093/cid/ciac493

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Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease

Authors: Hangchen Hu, Qian Wang, Haixia Su, Qiang Shao, Wenfeng Zhao, Guofeng Chen, Minjun Li, Yechun Xu

Journal: Angew Chem Int Ed Engl

PubMed ID: 36308706

Doi: 10.1002/anie.202212378

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A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding

Authors: Shanelle Shillingford, Lei Zhang, Yulia Surovtseva, Sam Dorry, Elias Lolis, Anton M Bennett

Journal: J Biol Chem

PubMed ID: 36272649

Doi: 10.1016/j.jbc.2022.102617

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SCF regulates G2-M progression through control of CCNL1 ubiquitination

Authors: Siobhan O'Brien, Susan Kelso, Zachary Steinhart, Stephen Orlicky, Monika Mis, Yunhye Kim, Sichun Lin, Frank Sicheri, Stephane Angers

Journal: EMBO Rep

PubMed ID: 36278408

Doi: 10.15252/embr.202255044

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Rat Group IIA Secreted Phospholipase A Binds to Cytochrome c Oxidase and Inhibits Its Activity: A Possible Episode in the Development of Alzheimer's Disease

Authors: Adrijan Ivanušec, Jernej Šribar, Adrijana Leonardi, Maja Zorović, Marko Živin, Igor Križaj

Journal: Int J Mol Sci

PubMed ID: 36293221

Doi: 10.3390/ijms232012368

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CD4 T cell epitope abundance in ferritin core potentiates responses to hemagglutinin nanoparticle vaccines

Authors: Sean A Nelson, Katherine A Richards, Maryah A Glover, Francisco A Chaves, Michelle C Crank, Barney S Graham, Masaru Kanekiyo, Andrea J Sant

Journal: npj Vaccines

PubMed ID: 36289232

Doi: 10.1038/s41541-022-00547-0

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Structure of the core human NADPH oxidase NOX2

Authors: Sigrid Noreng, Naruhisa Ota, Yonglian Sun, Hoangdung Ho, Matthew Johnson, Christopher P Arthur, Kellen Schneider, Isabelle Lehoux, Christopher W Davies, Kyle Mortara, Kit Wong, Dhaya Seshasayee, Matthieu Masureel, Jian Payandeh, Tangsheng Yi, James T Koerber

Journal: Nat Commun

PubMed ID: 36241643

Doi: 10.1038/s41467-022-33711-0

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Sorting nexin-dependent therapeutic targeting of oncogenic epidermal growth factor receptor

Authors: Benjamin Atwell, Cheng-Yu Chen, Matthew Christofferson, William R Montfort, Joyce Schroeder

Journal: Cancer Gene Ther

PubMed ID: 36253541

Doi: 10.1038/s41417-022-00541-7

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Target RNA activates the protease activity of Craspase to confer antiviral defense

Authors: Xi Liu, Laixing Zhang, Hao Wang, Yu Xiu, Ling Huang, Zhengyu Gao, Ningning Li, Feixue Li, Weijia Xiong, Teng Gao, Yi Zhang, Maojun Yang, Yue Feng

Journal: Mol Cell

PubMed ID: 36306795

Doi: 10.1016/j.molcel.2022.10.007

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Fructose-6-phosphate-2-kinase/fructose-2,6-bisphosphatase regulates energy metabolism and synthesis of storage products in developing rice endosperm

Authors: Xiaoli Chen , Yi Ji , Weiying Zhao , Huanying Niu , Xue Yang , Xiaokang Jiang , Yipeng Zhang , Jie Lei , Hang Yang , Rongbo Chen , Chuanwei Gu , Hongyi Xu , Hui Dong , Erchao Duan , Xuan Teng , Yunlong Wang , Yuanyan Zhang , Wenwei Zhang , Yihua Wang , Jianmin Wan

Journal: Plant Sci

PubMed ID: 36270512

Doi: 10.1016/j.plantsci.2022.111503

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Isobutanol production by combined and metabolic engineering

Authors: Mamta Gupta, Matthew Wong, Kamran Jawed, Kamil Gedeon, Hannah Barrett, Marcelo Bassalo, Clifford Morrison, Danish Eqbal, Syed Shams Yazdani, Ryan T Gill, Jiaqi Huang, Marc Douaisi, Jonathan Dordick, Georges Belfort, Mattheos A G Koffas

Journal: Metab Eng Commun

PubMed ID: 36325486

Doi: 10.1016/j.mec.2022.e00210

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The Detection of Immunity against WT1 and SMAD4 of EpCAM Cancer Cells in Malignant Pleural Effusion

Authors: Terutsugu Koya, Yo Niida, Misa Togi, Kenichi Yoshida, Takuya Sakamoto, Hiroki Ura, Sumihito Togi, Tomohisa Kato, Sohsuke Yamada, Haruo Sugiyama, Shigeo Koido, Shigetaka Shimodaira

Journal: Int J Mol Sci

PubMed ID: 36293034

Doi: 10.3390/ijms232012177

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DNA damage-induced nuclear import of HSP90α is promoted by Aha1

Authors: Nupur Fangaria, Khushboo Rani, Priyanka Singh, Sandeep Dey, Kota Arun Kumar, Sunanda Bhattacharyya

Journal: Mol Biol Cell

PubMed ID: 36260391

Doi: 10.1091/mbc.E21-11-0554

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Identification of human MHC-I HPV18 E6/E7-specific CD8 + T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice

Authors: Shiwen Peng, Deyin Xing, Louise Ferrall, Ya-Chea Tsai, Chien-Fu Hung, T-C Wu

Journal: J Biomed Sci

PubMed ID: 36224625

Doi: 10.1186/s12929-022-00864-5

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A broadly protective vaccine against cutaneous human papillomaviruses

Authors: Filipe Colaco Mariz, Kathrin Balz, Manuela Dittrich, Yueru Zhang, Fan Yang, Xueer Zhao, Angelo Bolchi, Simone Ottonello, Martin Müller

Journal: npj Vaccines

PubMed ID: 36216845

Doi: 10.1038/s41541-022-00539-0

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Comparison of the kinetics and magnitude of antibody responses to different SARS-CoV-2 proteins in Sinopharm/BBIBP-CorV vaccinees following the BNT162b2 booster or natural infection

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Shashika Dayarathna, Thashmi Nimasha, Thushali Ranasinghe, Jeewantha Jayamali, Achala Kamaladasa, Maneshka Karunanada, Lahiru Perera, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: PLoS ONE

PubMed ID: 36227884

Doi: 10.1371/journal.pone.0274845

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Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination

Authors: Jia Xin Chua, Lindy Gillian Durrant, Yin Ling Chok, Oi Ming Lai

Journal: iScience

PubMed ID: 36277260

Doi: 10.1016/j.isci.2022.105379

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A novel rhesus macaque model of Huntington's disease recapitulates key neuropathological changes along with motor and cognitive decline

Authors: Alison R Weiss, William A Liguore, Kristin Brandon, Xiaojie Wang, Zheng Liu, Jacqueline S Domire, Dana Button, Sathya Srinivasan, Christopher D Kroenke, Jodi L McBride

Journal: Elife

PubMed ID: 36205397

Doi: 10.7554/eLife.77568

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Comparative proteomic analysis reveals novel insights into the continuous cropping induced response in Scrophularia ningpoensis

Authors: Jiachen Sun, Xuejiao Li, Zhuo Qu, Huairui Wang, Yao Cheng, Shengjie Dong, Hui Zhao

Journal: J Sci Food Agric

PubMed ID: 36271763

Doi: 10.1002/jsfa.12284

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A dataset comprised of binding interactions for 104,972 antibodies against a SARS-CoV-2 peptide

Authors: Emily Engelhart, Ryan Emerson, Leslie Shing, Chelsea Lennartz, Daniel Guion, Mary Kelley, Charles Lin, Randolph Lopez, David Younger, Matthew E Walsh

Journal: Sci Data

PubMed ID: 36289234

Doi: 10.1038/s41597-022-01779-4

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Autophagic flux restoration enhances the antitumor efficacy of tumor infiltrating lymphocytes

Authors: Chaoting Zhang, Yizhe Sun, Shance Li, Luyan Shen, Xia Teng, Yefei Xiao, Nan Wu, Zheming Lu

Journal: J Immunother Cancer

PubMed ID: 36307150

Doi: 10.1136/jitc-2022-004868

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ICG-Dimeric Her2-Specific Affibody Conjugates for Tumor Imaging and Photothermal Therapy for Her2-Positive Tumors

Authors: Dianlong Jia, Huimin Liu, Shuhui Zheng, Dandan Yuan, Ruohan Sun, Fei Wang, Yang Li, Hui Li, Fengjiao Yuan, Qing Fan, Zhenxiong Zhao

Journal: Mol Pharm

PubMed ID: 36315025

Doi: 10.1021/acs.molpharmaceut.2c00708

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A method for targeting a specified segment of DNA to a bacterial microorganelle

Authors: Jan Otoničar, Maja Hostnik, Maja Grundner, Rok Kostanjšek, Tajda Gredar, Maja Garvas, Zoran Arsov, Zdravko Podlesek, Cene Gostinčar, Jernej Jakše, Stephen J W Busby, Matej Butala

Journal: Nucleic Acids Res

PubMed ID: 36029110

Doi: 10.1093/nar/gkac714

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An inducible gene from glycoside hydrolase one family of decreases larval survival when feeding on host plant

Authors: Wei Chen, Yuhong Dong, Ling Zheng, Yingfang Lai, Feifei Li, Li Zhou, Beibei Wang, Minsheng You, Weiyi He

Journal: Front Physiol

PubMed ID: 36338470

Doi: 10.3389/fphys.2022.1013092

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Combating the SARS-CoV-2 Omicron (BA1) and BA2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies

Authors: Yingdan Wang, Xiang Zhang, Yunping Ma, Yanqun Wang, Wuqiang Zhan, Qinwen Zheng, Meng Zhang, Ping Ji, Mei Liu, Qianying Liu, Tingting Sun, Tongyu Zhu, Yumei Wen, Lei Sun, Jincun Zhao, Fan Wu, Zhenguo Chen, Jinghe Huang

Journal: Cell Discov

PubMed ID: 36207299

Doi: 10.1038/s41421-022-00463-6

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Active Pharmaceutical Ingredient Uptake by Zebrafish (Danio rerio) Oct2 (slc22a2) Transporter Expressed in Xenopus laevis Oocytes

Authors: Elisabeth D Chang, Stewart F Owen, Christer Hogstrand, Nic R Bury

Journal: Environ Toxicol Chem

PubMed ID: 36102855

Doi: 10.1002/etc.5480

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Transient State Kinetics of Apicoplast DNA Polymerase Suggests the Involvement of Accessory Factors for Efficient and Accurate DNA Synthesis

Authors: Anamika Kumari, Anjali Yadav, Indrajit Lahiri

Journal: Biochemistry

PubMed ID: 36251801

Doi: 10.1021/acs.biochem.2c00446

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A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction

Authors: John T Happ, Corvin D Arveseth, Jessica Bruystens, Daniela Bertinetti, Isaac B Nelson, Cristina Olivieri, Jingyi Zhang, Danielle S Hedeen, Ju-Fen Zhu, Jacob L Capener, Jan W Bröckel, Lily Vu, C C King, Victor L Ruiz-Perez, Xuecai Ge, Gianluigi Veglia, Friedrich W Herberg, Susan S Taylor, Benjamin R Myers

Journal: Nat Struct Mol Biol

PubMed ID: 36202993

Doi: 10.1038/s41594-022-00838-z

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Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation

Authors: Wen-Hsin Lee, Xiaorui Chen, I-Ju Liu, Jiin-Horng Lee, Chun-Mei Hu, Han-Chung Wu, Sheng-Kai Wang, Wen-Hwa Lee, Che Ma

Journal: Cell Rep

PubMed ID: 36288706

Doi: 10.1016/j.celrep.2022.111555

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Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity

Authors: Brett H Pogostin, Marina H Yu, Alon R Azares, Erin M Euliano, Cheuk Sun Edwin Lai, Gabriel Saenz, Samuel X Wu, Adam C Farsheed, Sarah M Melhorn, Tyler P Graf, Darren G Woodside, Jeffrey D Hartgerink, Kevin J McHugh

Journal: Biomater Sci

PubMed ID: 36102692

Doi: 10.1039/d2bm01242a

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Evasion of cGAS and TRIM5 defines pandemic HIV

Authors: Lorena Zuliani-Alvarez, Morten L Govasli, Jane Rasaiyaah, Chris Monit, Stephen O Perry, Rebecca P Sumner, Simon McAlpine-Scott, Claire Dickson, K M Rifat Faysal, Laura Hilditch, Richard J Miles, Frederic Bibollet-Ruche, Beatrice H Hahn, Till Boecking, Nikos Pinotsis, Leo C James, David A Jacques, Greg J Towers

Journal: Nat Microbiol

PubMed ID: 36289397

Doi: 10.1038/s41564-022-01247-0

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Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

Authors: Tilman L B Hölting, Florencia Cidre-Aranaz, Dana Matzek, Bastian Popper, Severin J Jacobi, Cornelius M Funk, Florian H Geyer, Jing Li, Ignazio Piseddu, Bruno L Cadilha, Stephan Ledderose, Jennifer Zwilling, Shunya Ohmura, David Anz, Annette Künkele, Frederick Klauschen, Thomas G P Grünewald, Maximilian M L Knott

Journal: Mol Cancer

PubMed ID: 36229873

Doi: 10.1186/s12943-022-01641-6

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Cancer stem cell antigen nanodisc cocktail elicits anti-tumor immune responses in melanoma

Authors: Marisa E Aikins, You Qin, Hannah E Dobson, Alireza Hassani Najafabadi, Kexing Lyu, Yao Xu, Ying Xin, Anna Schwendeman, Max S Wicha, Alfred E Chang, Qiao Li, James J Moon

Journal: J Control Release

PubMed ID: 36206945

Doi: 10.1016/j.jconrel.2022.09.061

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