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SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebraﬁsh

Authors: Fang Liang, Yu Zhang, Lin Li, Yexin Yang, Ji-Feng Fei, Yanmei Liu, Wei Qin

Journal: Nat Commun

PubMed ID: 35701400

Doi: 10.1038/s41467-022-31034-8

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Structure−Function Analysis of a Quinone-Dependent Dehydrogenase Capable of Deoxynivalenol Detoxification

Authors: Hua Yang , Ruxue Yan , Yue Li , Zhaoxin Lu , Xiaomei Bie , Haizhen Zhao , Fengxia Lu , Meirong Chen

Journal: J Agric Food Chem

PubMed ID: 35613468

Doi: 10.1021/acs.jafc.2c01083

Products & Services: Gene Synthesis

The Pre-Existing Human Antibody Repertoire to Computationally Optimized Influenza H1 Hemagglutinin Vaccines

Authors: Kaito Nagashima, John V Dzimianski, Julianna Han, Nada Abbadi, Aaron D Gingerich, Fredejah Royer, Sara O'Rourke, Giuseppe A Sautto, Ted M Ross, Andrew B Ward, Rebecca M DuBois, Jarrod J Mousa

Journal: J Immunol

PubMed ID: 35697384

Doi: 10.4049/jimmunol.2101171

Products & Services: Plasmid DNA Preparation

Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx

Authors: Tae Gun Kang, Kee Woong Kwon, Kyungsoo Kim, Insuk Lee, Myeong Joon Kim, Sang-Jun Ha, Sung Jae Shin

Journal: Nat Commun

PubMed ID: 35672321

Doi: 10.1038/s41467-022-30914-3

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Senescent cells limit p53 activity via multiple mechanisms to remain viable

Authors: Ines Sturmlechner, Chance C Sine, Karthik B Jeganathan, Cheng Zhang, Raul O Fierro Velasco, Darren J Baker, Hu Li, Jan M van Deursen

Journal: Nat Commun

PubMed ID: 35764649

Doi: 10.1038/s41467-022-31239-x

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of inositol lipid metabolism in gut-associated Bacteroidetes

Authors: Stacey L Heaver, Henry H Le, Peijun Tang, Arnaud Baslé, Claudia Mirretta Barone, Dai Long Vu, Jillian L Waters, Jon Marles-Wright, Elizabeth L Johnson, Dominic J Campopiano, Ruth E Ley

Journal: Nat Microbiol

PubMed ID: 35725777

Doi: 10.1038/s41564-022-01152-6

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Production of Plant Sesquiterpene Lactone Parthenolide in the Yeast Cell Factory

Authors: Yiting Shi, Tianyu Dong, Boxuan Zeng, Mingdong Yao, Ying Wang, Zexiong Xie, Wenhai Xiao, Yingjin Yuan

Journal: ACS Synth Biol

PubMed ID: 35723427

Doi: 10.1021/acssynbio.2c00132

Products & Services: Recombinant Antibody Expression

Human Superantibodies to 3CL Inhibit Replication of SARS-CoV-2 across Variants

Authors: Kittirat Glab-Ampai, Kanasap Kaewchim, Thanatsaran Saenlom, Watayagorn Thepsawat, Kodchakorn Mahasongkram, Nitat Sookrung, Wanpen Chaicumpa, Monrat Chulanetra

Journal: Int J Mol Sci

PubMed ID: 35743031

Doi: 10.3390/ijms23126587

Products & Services: Plasmid DNA Preparation

Development of a biosensor based on a new marine luciferase fused to an affibody to assess Her2 expression in living cells

Authors: Laura Rodríguez de la Fuente, Irene Golán Cancela, Ánxela M Estévez-Salguero, Pablo Iglesias, José A Costoya

Journal: Anal Chim Acta

PubMed ID: 35934341

Doi: 10.1016/j.aca.2022.340084

Products & Services: PCR Cloning and Subcloning

A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly

Authors: Francisco Figueiredo, Mónica Lopes-Marques, Bruno Almeida, Nena Matscheko, Pedro M Martins, Alexandra Silva, Sandra Macedo-Ribeiro

Journal: Cells

PubMed ID: 35741099

Doi: 10.3390/cells11121969

Products & Services: Proteins, Expression, Isolation and Analysis

Longitudinal profile of neutralizing and binding antibodies in vaccinated and convalescent COVID-19 cohorts by chemiluminescent immunoassays

Authors: Xiaowen Dou, Enyun Wang, Ruiwei Jiang, Min Li, Dan Xiong, Baoqing Sun, Xiuming Zhang

Journal: Immun Inflamm Dis

PubMed ID: 35634960

Doi: 10.1002/iid3.612

L and L Improve Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats through Suppression of Oxidative Stress

Authors: Shujun Jiang, Quanyan Cai, Yang Gao, Hui Dong, Yan Zhao, Fan Wu, Xin Ba, Yang Luan, Xin Zou, Lijun Xu, Fuer Lu

Journal: Evid Based Complement Alternat Med

PubMed ID: 35707467

Doi: 10.1155/2022/4187359

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The Cross-Protective Immunity Landscape Among Different SARS-CoV-2 Variant RBDs

Authors: Wenqiang Sun, Lihong He, Huicong Lou, Wenhui Fan, Limin Yang, Gong Cheng, Wenjun Liu, Lei Sun

Journal: Front Immunol

PubMed ID: 35757743

Doi: 10.3389/fimmu.2022.898520

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Activated Stellate Cell Paracrine HGF Exacerbated Pancreatic Cancer Cell Ferroptosis Resistance

Authors: Qiwei Wu, Lian Song, Yaxin Guo, Sai Liu, Wenyao Wang, Huli Liu, Aihua Gong, Xiang Liao, Haitao Zhu, Dongqing Wang

Journal: Oxid Med Cell Longev

PubMed ID: 35693705

Doi: 10.1155/2022/2985249

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Preclinical evaluation of a plant-derived SARS-CoV-2 subunit vaccine: Protective efficacy, immunogenicity, safety, and toxicity

Authors: Balamurugan Shanmugaraj, Narach Khorattanakulchai, Chalisa Panapitakkul, Ashwini Malla, Rawiwan Im-Erbsin, Manutsanun Inthawong, Piyanate Sunyakumthorn, Taweewun Hunsawong, Chonticha Klungthong, Matthew C Reed, Taratorn Kemthong, Nutchanat Suttisan, Suchinda Malaivijitnond, Passaraporn Srimangkornkaew, Aekkarin Klinkhamhom, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Suthira Taychakhoonavudh, Waranyoo Phoolcharoen

Journal: Vaccine

PubMed ID: 35697573

Doi: 10.1016/j.vaccine.2022.05.087

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Uricase sensitizes hepatocellular carcinoma cells to 5-fluorouracil through uricase-uric acid-UMP synthase axis

Authors: Saihong Yu, Zhuduo Li, Linglan Tu, Yiyi Pu, Dongmei Yan, Xiaoju Wang, Xiaoliang Zheng, Jie Yu

Journal: J Physiol Biochem

PubMed ID: 35674867

Doi: 10.1007/s13105-022-00894-5

Products & Services: Plasmid DNA Preparation

Chemoproteomic identification of CO-dependent lysine carboxylation in proteins

Authors: Dustin T King, Sha Zhu, Darryl B Hardie, Jesús E Serrano-Negrón, Zarina Madden, Subramania Kolappan, David J Vocadlo

Journal: Nat Chem Biol

PubMed ID: 35710617

Doi: 10.1038/s41589-022-01043-1

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Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA

Authors: Elena S Kim, Jun Zhou, Hu Zhang, Alexander Marchetti, Maarten van de Klundert, Dawei Cai, Xiaoyang Yu, Bidisha Mitra, Yuanjie Liu, Mu Wang, Ulrike Protzer, Haitao Guo

Journal: PLoS Pathog

PubMed ID: 35679251

Doi: 10.1371/journal.ppat.1010576

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Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors

Authors: Jiayue Su, Desheng Liu, Fan Yang, Mei-Qing Zuo, Chang Li, Meng-Qiu Dong, Shan Sun, Sen-Fang Sui

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35733257

Doi: 10.1073/pnas.2200158119

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Increased resistance of SARS-CoV-2 Lambda variant to antibody neutralization

Authors: Huimin Guo, Qing Fan, Shuo Song, Senlin Shen, Bing Zhou, Haiyan Wang, Lin Cheng, Xiangyang Ge, Bin Ju, Zheng Zhang

Journal: JOURNAL OF CLINICAL VIROLOGY

PubMed ID: 35461042

Doi: 10.1016/j.jcv.2022.105162

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Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease

Authors: Nikhil Panicker, Tae-In Kam, Hu Wang, Stewart Neifert, Shih-Ching Chou, Manoj Kumar, Saurav Brahmachari, Aanishaa Jhaldiyal, Jared T Hinkle, Fatih Akkentli, Xiaobo Mao, Enquan Xu, Senthilkumar S Karuppagounder, Eric T Hsu, Sung-Ung Kang, Olga Pletnikova, Juan Troncoso, Valina L Dawson, Ted M Dawson

Journal: Neuron

PubMed ID: 35654037

Doi: 10.1016/j.neuron.2022.05.009

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Histidine Ligated Iron-Sulfur Peptides

Authors: Luca Valer, Daniele Rossetto, Taylor Parkkila, Lorenzo Sebastianelli, Graziano Guella, Amber L Hendricks, James A Cowan, Lingzi Sang, Sheref S Mansy

Journal: Chembiochem

PubMed ID: 35674331

Doi: 10.1002/cbic.202200202

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The Effects of Qinghao-Kushen and Its Active Compounds on the Biological Characteristics of Liver Cancer Cells

Authors: Jingmin Ji, Zhiqin Zhang, Qing Peng, Liyuan Hao, Yinglin Guo, Yu Xue, Yiwei Liu, Caige Li, Xinli Shi

Journal: Evid Based Complement Alternat Med

PubMed ID: 35722140

Doi: 10.1155/2022/8763510

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Towards a general approach for tailoring the hydrophobic binding site of phenylalanine ammonia-lyases

Authors: Souad Diana Tork, Mădălina Elena Moisă, Lilla Cserepes, Alina Filip, Levente Csaba Nagy, Florin Dan Irimie, László Csaba Bencze

Journal: Sci Rep

PubMed ID: 35739148

Doi: 10.1038/s41598-022-14585-0

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Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes

Authors: Lucy C Walters, Daniel Rozbesky, Karl Harlos, Max Quastel, Hong Sun, Sebastian Springer, Robert P Rambo, Fiyaz Mohammed, E Yvonne Jones, Andrew J McMichael, Geraldine M Gillespie

Journal: Cell Rep

PubMed ID: 35705051

Doi: 10.1016/j.celrep.2022.110959

Products & Services: Catalog Peptides

Microfluidic T Cell Selection by Cellular Avidity

Authors: Julian F Ashby, Julien Schmidt, Neelima Kc, Armand Kurum, Caroline Koch, Alexandre Harari, Li Tang, Sam H Au

Journal: Adv Healthc Mater

PubMed ID: 35657072

Doi: 10.1002/adhm.202200169

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Successful Preservation of Native BCR::ABL1 in Chronic Myeloid Leukemia Primary Leukocytes Reveals a Reduced Kinase Activity

Authors: Christian Boni, Massimiliano Bonifacio, Marzia Vezzalini, Luigi Scaffidi, Luisa Tomasello, Laurie L Parker, Diego Boscarino, Dino Paladin, Mauro Krampera, Claudio Sorio

Journal: Front Oncol

PubMed ID: 35756686

Doi: 10.3389/fonc.2022.904510

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Comparative Characterization of Different Molecular Formats of Bispecific Antibodies Targeting EGFR and PD-L1

Authors: Nishant Mohan, Atul Agrawal, Yi Shen, Katie L Winarski, Yukinori Endo, Milos Dokmanovic, Deborah Schmiel, Jiwen Zheng, David S Rotstein, Lorraine C Pelosof, Wen Jin Wu

Journal: Pharmaceutics

PubMed ID: 35890277

Doi: 10.3390/pharmaceutics14071381

Products & Services: Plasmid DNA Preparation

The Use of Endo-Cellulase and Endo-Xylanase for the Extraction of Apple Pectins as Factors Modifying Their Anticancer Properties and Affecting Their Synergy with the Active Form of Irinotecan

Authors: Jerzy Maksymowicz, Anna Palko-Łabuz, Beata Sobieszczańska, Mateusz Chmielarz, Mirosława Ferens-Sieczkowska, Magdalena Skonieczna, Agnieszka Wikiera, Olga Wesołowska, Kamila Środa-Pomianek

Journal: Pharmaceuticals (Basel)

PubMed ID: 35745651

Doi: 10.3390/ph15060732

Products & Services: Recombinant Proteins

Individual and Synergistic Anti-Coronavirus Activities of SOCS1/3 Antagonist and Interferon α1 Peptides

Authors: Chulbul M Ahmed, Tristan R Grams, David C Bloom, Howard M Johnson, Alfred S Lewin

Journal: Front Immunol

PubMed ID: 35799776

Doi: 10.3389/fimmu.2022.902956

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SASH1 knockdown suppresses TRAF6 ubiquitination to regulate hemangioma progression by mediating EZH2 degradation

Authors: Xueyuan Yu, Nuonuo Cong, Xiangyu Liu, Rui Wang, Daxu Li

Journal: Exp Cell Res

PubMed ID: 35772492

Doi: 10.1016/j.yexcr.2022.113270

Products & Services: Proteins, Expression, Isolation and Analysis

Inhibition of histone acetyltransferase GCN5 by a transcription factor FgPacC controls fungal adaption to host-derived iron stress

Authors: Qin Gu, Yujie Wang, Xiaozhen Zhao, Bingqin Yuan, Mengxuan Zhang, Zheng Tan, Xinyue Zhang, Yun Chen, Huijun Wu, Yuming Luo, Nancy P Keller, Xuewen Gao, Zhonghua Ma

Journal: Nucleic Acids Res

PubMed ID: 35687128

Doi: 10.1093/nar/gkac498

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Immunogenicity of Varicella Zoster Virus DNA Vaccines Encoding Glycoprotein E and Immediate Early Protein 63 in Mice

Authors: Jie Liu, Junyang Lin, Linjun Cai, Jie Sun, Xue Ding, Cenrong Wang, Yanchun Wu, Xiaoling Gao, Weiheng Su, Chunlai Jiang

Journal: Viruses

PubMed ID: 35746685

Doi: 10.3390/v14061214

Products & Services: Mammalian Expression

LncRNA RAD51-AS1 Regulates Human Bone Marrow Mesenchymal Stem Cells via Interaction with YBX1 to Ameliorate Osteoporosis

Authors: Beichen Li, Jing Wang, Fangrong Xu, Qinjue Wang, Quan Liu, Guantong Wang, Dengshun Miao, Qiang Sun

Journal: Stem Cell Rev Rep

PubMed ID: 35727431

Doi: 10.1007/s12015-022-10408-x

Products & Services: Proteins, Expression, Isolation and Analysis

Investigating the specificity of endothelin-traps as a potential therapeutic tool for endothelin-1 related disorders

Authors: Arjun Jain, Kristof Bozovicar, Vidhi Mehrotra, Tomaz Bratkovic, Martin H Johnson, Ira Jha

Journal: World J Diabetes

PubMed ID: 35800412

Doi: 10.4239/wjd.v13.i6.434

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Arabidopsis HOPS subunit VPS41 carries out plant-specific roles in vacuolar transport and vegetative growth

Authors: Dong Jiang, Yilin He, Xiangui Zhou, Zhiran Cao, Lei Pang, Sheng Zhong, Liwen Jiang, Ruixi Li

Journal: Plant Physiol

PubMed ID: 35417008

Doi: 10.1093/plphys/kiac167

Products & Services: Proteins, Expression, Isolation and Analysis

A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine

Authors: Jeeva Subbiah, Judy Oh, Ki-Hye Kim, Chong-Hyun Shin, Bo Ryoung Park, Noopur Bhatnagar, Baik-Lin Seong, Bao-Zhong Wang, Sang-Moo Kang

Journal: npj Vaccines

PubMed ID: 35768475

Doi: 10.1038/s41541-022-00498-6

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Sequence-specific H, C and N backbone NMR assignments for the N-terminal IgV-like domain (D1) and full extracellular region (D1D2) of PD-L1

Authors: Kayleigh Walker, Lorna C Waters, Geoff Kelly, Frederick W Muskett, Mark D Carr

Journal: Biomol NMR Assign

PubMed ID: 35675028

Doi: 10.1007/s12104-022-10092-5

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Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant

Authors: Kirsten E Lyke, Robert L Atmar, Clara Dominguez Islas, Christine M Posavad, Daniel Szydlo, Rahul Paul Chourdhury, Meagan E Deming, Amanda Eaton, Lisa A Jackson, Angela R Branche, Hana M El Sahly, Christina A Rostad, Judith M Martin, Christine Johnston, Richard E Rupp, Mark J Mulligan, Rebecca C Brady, Robert W Frenck, Martín Bäcker, Angelica C Kottkamp, Tara M Babu, Kumaravel Rajakumar, Srilatha Edupuganti, David Dobrzynski, Rhea N Coler, Janet I Archer, Sonja Crandon, Jillian A Zemanek, Elizabeth R Brown, Kathleen M Neuzil, David S Stephens, Diane J Post, Seema U Nayak, Mehul S Suthar, Paul C Roberts, John H Beigel, David C Montefiori

Journal: Cell Rep Med

PubMed ID: 35798000

Doi: 10.1016/j.xcrm.2022.100679

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Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses

Authors: Ghizlane Maarifi, Marie-France Martin, Abderezak Zebboudj, Aude Boulay, Pierre Nouaux, Juliette Fernandez, Justine Lagisquet, Dominique Garcin, Raphael Gaudin, Nathalie J Arhel, Sébastien Nisole

Journal: Cell Chem Biol

PubMed ID: 35728599

Doi: 10.1016/j.chembiol.2022.05.009

Products & Services: Recombinant Proteins

Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity-Making Mutations

Authors: Juan Luis Pacheco-Garcia, Dmitry S Loginov, Ernesto Anoz-Carbonell, Pavla Vankova, Rogelio Palomino-Morales, Eduardo Salido, Petr Man, Milagros Medina, Athi N Naganathan, Angel L Pey

Journal: Antioxidants (Basel)

PubMed ID: 35740007

Doi: 10.3390/antiox11061110

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Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2

Authors: Maria Martinez-Molledo, Emmanuel Nji, Nicolas Reyes

Journal: Nat Struct Mol Biol

PubMed ID: 35710838

Doi: 10.1038/s41594-022-00786-8

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Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in

Authors: Xiaolu Tai, Yaqun Zhang, Jindong Yao, Xuan Li, Jun Liu, Jiazhen Han, Jianjun Lyu, Gufa Lin, Chao Zhang