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A pseudovirus-based platform to measure neutralizing antibodies in Mexico using SARS-CoV-2 as proof-of-concept

Authors: José Antonio Cruz-Cardenas, Michelle Gutierrez, Alejandra López-Arredondo, Julio Enrique Castañeda-Delgado, Augusto Rojas-Martinez, Yukio Nakamura, José Antonio Enciso-Moreno, Laura A Palomares, Marion E G Brunck

Journal: Sci Rep

PubMed ID: 36289285

Doi: 10.1038/s41598-022-22921-7

Pathobiology and dysbiosis of the respiratory and intestinal microbiota in 14 months old Golden Syrian hamsters infected with SARS-CoV-2

Authors: Brittany Seibert, C Joaquín Cáceres, Silvia Carnaccini, Stivalis Cardenas-Garcia, L Claire Gay, Lucia Ortiz, Ginger Geiger, Daniela S Rajao, Elizabeth Ottesen, Daniel R Perez

Journal: PLoS Pathog

PubMed ID: 36279276

Doi: 10.1371/journal.ppat.1010734

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A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding

Authors: Shanelle Shillingford, Lei Zhang, Yulia Surovtseva, Sam Dorry, Elias Lolis, Anton M Bennett

Journal: J Biol Chem

PubMed ID: 36272649

Doi: 10.1016/j.jbc.2022.102617

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SCF regulates G2-M progression through control of CCNL1 ubiquitination

Authors: Siobhan O'Brien, Susan Kelso, Zachary Steinhart, Stephen Orlicky, Monika Mis, Yunhye Kim, Sichun Lin, Frank Sicheri, Stephane Angers

Journal: EMBO Rep

PubMed ID: 36278408

Doi: 10.15252/embr.202255044

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Rat Group IIA Secreted Phospholipase A Binds to Cytochrome c Oxidase and Inhibits Its Activity: A Possible Episode in the Development of Alzheimer's Disease

Authors: Adrijan Ivanušec, Jernej Šribar, Adrijana Leonardi, Maja Zorović, Marko Živin, Igor Križaj

Journal: Int J Mol Sci

PubMed ID: 36293221

Doi: 10.3390/ijms232012368

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CD4 T cell epitope abundance in ferritin core potentiates responses to hemagglutinin nanoparticle vaccines

Authors: Sean A Nelson, Katherine A Richards, Maryah A Glover, Francisco A Chaves, Michelle C Crank, Barney S Graham, Masaru Kanekiyo, Andrea J Sant

Journal: npj Vaccines

PubMed ID: 36289232

Doi: 10.1038/s41541-022-00547-0

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Structure of the core human NADPH oxidase NOX2

Authors: Sigrid Noreng, Naruhisa Ota, Yonglian Sun, Hoangdung Ho, Matthew Johnson, Christopher P Arthur, Kellen Schneider, Isabelle Lehoux, Christopher W Davies, Kyle Mortara, Kit Wong, Dhaya Seshasayee, Matthieu Masureel, Jian Payandeh, Tangsheng Yi, James T Koerber

Journal: Nat Commun

PubMed ID: 36241643

Doi: 10.1038/s41467-022-33711-0

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Sorting nexin-dependent therapeutic targeting of oncogenic epidermal growth factor receptor

Authors: Benjamin Atwell, Cheng-Yu Chen, Matthew Christofferson, William R Montfort, Joyce Schroeder

Journal: Cancer Gene Ther

PubMed ID: 36253541

Doi: 10.1038/s41417-022-00541-7

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Target RNA activates the protease activity of Craspase to confer antiviral defense

Authors: Xi Liu, Laixing Zhang, Hao Wang, Yu Xiu, Ling Huang, Zhengyu Gao, Ningning Li, Feixue Li, Weijia Xiong, Teng Gao, Yi Zhang, Maojun Yang, Yue Feng

Journal: Mol Cell

PubMed ID: 36306795

Doi: 10.1016/j.molcel.2022.10.007

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Deciphering the virulence potential of Listeria monocytogenes in the Norwegian meat and salmon processing industry by combining whole genome sequencing and in vitro data

Authors: Eva Wagner, Annette Fagerlund, Sarah Thalguter, Merete Rusås Jensen, Even Heir, Trond Møretrø, Birgitte Moen, Solveig Langsrud, Kathrin Rychli

Journal: Int J Food Microbiol

PubMed ID: 36240603

Doi: 10.1016/j.ijfoodmicro.2022.109962

Products & Services: Protein and Antibody Isolation

Prostaglandin E synchronizes lunar-regulated beach spawning in grass puffers

Authors: Junfeng Chen, Yuma Katada, Kousuke Okimura, Taiki Yamaguchi, Ying-Jey Guh, Tomoya Nakayama, Michiyo Maruyama, Yuko Furukawa, Yusuke Nakane, Naoyuki Yamamoto, Yoshikatsu Sato, Hironori Ando, Asako Sugimura, Kazufumi Tabata, Ayato Sato, Takashi Yoshimura

Journal: Curr Biol

PubMed ID: 36306789

Doi: 10.1016/j.cub.2022.09.062

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Proline-Rich Region II (PRR2) Plays an Important Role in Tau-Glycan Interaction: An NMR Study

Authors: Anqesha Murray, Lufeng Yan, James M Gibson, Jian Liu, David Eliezer, Guy Lippens, Fuming Zhang, Robert J Linhardt, Jing Zhao, Chunyu Wang

Journal: Biomolecules

PubMed ID: 36358923

Doi: 10.3390/biom12111573

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Durability of antibodies post vaccination with two doses of inactivated BBIBP-CorV vaccine

Authors: Sally Mahmoud, Subhashini Ganesan, Narjes Saheb Sharif-Askari, Flavia Cantarutti, Hannah Wilson, Pauline Ogrodzki, Rabih Halwani, Nawal Alkaabi, Walid Abbas Zaher

Journal: Curr Med Res Opin

PubMed ID: 36274640

Doi: 10.1080/03007995.2022.2139969

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The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation

Authors: Radwa E Mahgoub, Feda E Mohamed, Lara Alzyoud, Bassam R Ali, Juliana Ferreira, Wael M Rabeh, Shaikha S AlNeyadi, Noor Atatreh, Mohammad A Ghattas

Journal: Molecules

PubMed ID: 36235244

Doi: 10.3390/molecules27196710

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Quantum Dot-Based Screening Identifies F3 Peptide and Reveals Cell Surface Nucleolin as a Therapeutic Target for Rhabdomyosarcoma

Authors: Dzhangar Dzhumashev, Andrea Timpanaro, Safa Ali, Andrea J De Micheli, Kamel Mamchaoui, Ilaria Cascone, Jochen Rössler, Michele Bernasconi

Journal: Cancers (Basel)

PubMed ID: 36291832

Doi: 10.3390/cancers14205048

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Establishment of a protocol for preventive vaccination against equine insect bite hypersensitivity

Authors: Sara Bjork Stefansdottir, Sigridur Jonsdottir, Holmfridur Kristjansdottir, Vilhjalmur Svansson, Eliane Marti, Sigurbjorg Torsteinsdottir

Journal: Vet Immunol Immunopathol

PubMed ID: 36272211

Doi: 10.1016/j.vetimm.2022.110502

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Development and in vitro characterization of a humanized scFv against fungal infections

Authors: Tomas Di Mambro, Tania Vanzolini, Marzia Bianchi, Rita Crinelli, Barbara Canonico, Filippo Tasini, Michele Menotta, Mauro Magnani

Journal: PLoS ONE

PubMed ID: 36315567

Doi: 10.1371/journal.pone.0276786

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PCDetection: PolyA-CRISPR/Cas12a-based miRNA detection without PAM restriction

Authors: Mingtian Zhong , Kaizhao Chen , Wenjun Sun , Xiangyang Li , Shisheng Huang , Qingzhou Meng , Bo Sun , Xingxu Huang , Xinjie Wang , Xiaodong Ma , Peixiang Ma

Journal: Biosens Bioelectron

PubMed ID: 35797934

Doi: 10.1016/j.bios.2022.114497

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A switchable Cas12a enabling CRISPR-based direct histone deacetylase activity detection

Authors: Wenyuan Kang , Lin Liu , Peihang Yu , Tianyi Zhang , Chunyang Lei , Zhou Nie

Journal: Biosens Bioelectron

PubMed ID: 35700604

Doi: doi.org/10.1016/j.bios.2022.114468

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Asymmetric Stratification-Induced Polarity Loss and Coordinated Individual Cell Movements Drive Directional Migration of Vertebrate Epithelium

Authors: Yunzhe Lu , Ruolan Deng , Huanyang You , Yishu Xu , Christopher Antos , Jianlong Sun , Ophir D Klein , Pengfei Lu

Journal: Cell Rep

PubMed ID: 33053348

Doi: 10.1016/j.celrep.2020.108246

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Epstein-Barr Virus Tegument Protein BKRF4 is a Histone Chaperone

Authors: Yongrui Liu , Yue Li , Hongyu Bao , Yanhong Liu , Liu Chen , Hongda Huang

Journal: J Mol Biol

PubMed ID: 35870648

Doi: 10.1016/j.jmb.2022.167756

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De novo design of anti-tuberculosis agents using a structure-based deep learning method

Authors: Sowmya Ramaswamy Krishnan, Navneet Bung, Siladitya Padhi, Gopalakrishnan Bulusu, Parimal Misra, Manojit Pal, Srinivas Oruganti, Rajgopal Srinivasan, Arijit Roy

Journal: J Mol Graph Model

PubMed ID: 36257148

Doi: 10.1016/j.jmgm.2022.108361

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The Detection of Immunity against WT1 and SMAD4 of EpCAM Cancer Cells in Malignant Pleural Effusion

Authors: Terutsugu Koya, Yo Niida, Misa Togi, Kenichi Yoshida, Takuya Sakamoto, Hiroki Ura, Sumihito Togi, Tomohisa Kato, Sohsuke Yamada, Haruo Sugiyama, Shigeo Koido, Shigetaka Shimodaira

Journal: Int J Mol Sci

PubMed ID: 36293034

Doi: 10.3390/ijms232012177

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Isobutanol production by combined and metabolic engineering

Authors: Mamta Gupta, Matthew Wong, Kamran Jawed, Kamil Gedeon, Hannah Barrett, Marcelo Bassalo, Clifford Morrison, Danish Eqbal, Syed Shams Yazdani, Ryan T Gill, Jiaqi Huang, Marc Douaisi, Jonathan Dordick, Georges Belfort, Mattheos A G Koffas

Journal: Metab Eng Commun

PubMed ID: 36325486

Doi: 10.1016/j.mec.2022.e00210

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The large plasmid carried class 1 integrons mediated multidrug resistance of foodborne Indiana

Authors: Xuefeng Wang, Tian Wang, Mengjiao Guo, Chengcheng Zhang, Zongyi Bo, Yantao Wu, Guoxiang Chao

Journal: Front Microbiol

PubMed ID: 36312970

Doi: 10.3389/fmicb.2022.991326

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Multifunctional chemical inhibitors of the florigen activation complex discovered by structure-based high-throughput screening

Authors: Ken-Ichiro Taoka, Ikumi Kawahara, Shoko Shinya, Ken-Ichi Harada, Eiki Yamashita, Zenpei Shimatani, Kyoko Furuita, Tomoaki Muranaka, Tokitaka Oyama, Rie Terada, Atsushi Nakagawa, Toshimichi Fujiwara, Hiroyuki Tsuji, Chojiro Kojima

Journal: Plant J

PubMed ID: 36288411

Doi: 10.1111/tpj.16008

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Development and characterization of a new monoclonal antibody against SARS-CoV-2 NSP12 (RdRp)

Authors: Wen Meng, Siying Guo, Simon Cao, Masahiro Shuda, Lindsey R Robinson-McCarthy, Kevin R McCarthy, Yoko Shuda, Alberto E Paniz Mondolfi, Clare Bryce, Zachary Grimes, Emilia M Sordillo, Carlos Cordon-Cardo, Pengfei Li, Hu Zhang, Stanley Perlman, Haitao Guo, Shou-Jiang Gao, Yuan Chang, Patrick S Moore

Journal: J Med Virol

PubMed ID: 36271490

Doi: 10.1002/jmv.28246

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A simple thermodynamic description of phase separation of Nup98 FG domains

Authors: Sheung Chun Ng, Dirk Görlich

Journal: Nat Commun

PubMed ID: 36257947

Doi: 10.1038/s41467-022-33697-9

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A novel rhesus macaque model of Huntington's disease recapitulates key neuropathological changes along with motor and cognitive decline

Authors: Alison R Weiss, William A Liguore, Kristin Brandon, Xiaojie Wang, Zheng Liu, Jacqueline S Domire, Dana Button, Sathya Srinivasan, Christopher D Kroenke, Jodi L McBride

Journal: Elife

PubMed ID: 36205397

Doi: 10.7554/eLife.77568

Products & Services: Plasmid DNA Preparation

Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

Authors: Tilman L B Hölting, Florencia Cidre-Aranaz, Dana Matzek, Bastian Popper, Severin J Jacobi, Cornelius M Funk, Florian H Geyer, Jing Li, Ignazio Piseddu, Bruno L Cadilha, Stephan Ledderose, Jennifer Zwilling, Shunya Ohmura, David Anz, Annette Künkele, Frederick Klauschen, Thomas G P Grünewald, Maximilian M L Knott

Journal: Mol Cancer

PubMed ID: 36229873

Doi: 10.1186/s12943-022-01641-6

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An inducible gene from glycoside hydrolase one family of decreases larval survival when feeding on host plant

Authors: Wei Chen, Yuhong Dong, Ling Zheng, Yingfang Lai, Feifei Li, Li Zhou, Beibei Wang, Minsheng You, Weiyi He

Journal: Front Physiol

PubMed ID: 36338470

Doi: 10.3389/fphys.2022.1013092

Products & Services: Recombinant Antibody Expression

Fructose-6-phosphate-2-kinase/fructose-2,6-bisphosphatase regulates energy metabolism and synthesis of storage products in developing rice endosperm

Authors: Xiaoli Chen , Yi Ji , Weiying Zhao , Huanying Niu , Xue Yang , Xiaokang Jiang , Yipeng Zhang , Jie Lei , Hang Yang , Rongbo Chen , Chuanwei Gu , Hongyi Xu , Hui Dong , Erchao Duan , Xuan Teng , Yunlong Wang , Yuanyan Zhang , Wenwei Zhang , Yihua Wang , Jianmin Wan

Journal: Plant Sci

PubMed ID: 36270512

Doi: 10.1016/j.plantsci.2022.111503

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Sex Difference Leads to Differential Gene Expression Patterns and Therapeutic Efficacy in Mucopolysaccharidosis IVA Murine Model Receiving AAV8 Gene Therapy

Authors: Matthew Piechnik, Paige C Amendum, Kazuki Sawamoto, Molly Stapleton, Shaukat Khan, Nidhi Fnu, Victor Álvarez, Angelica Maria Herreño Pachon, Olivier Danos, Joseph T Bruder, Subha Karumuthil-Melethil, Shunji Tomatsu

Journal: Int J Mol Sci

PubMed ID: 36293546

Doi: 10.3390/ijms232012693

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External quality assessment of SARS-CoV-2 serology in European expert laboratories, April 2021

Authors: Ramona Mögling, Francesca Colavita, Johan Reimerink, Angeliki Melidou, Katrin Leitmeyer, Maria Keramarou, Daniele Lapa, Massimo Francalancia, Jean-Luc Murk, Ann Vossen, Fabrizio Carletti, Boris Hogema, Adam Meijer, Liesbet Deprez, Antonino di Caro, Concetta Castilletti, Chantal Bem Reusken

Journal: Euro Surveill

PubMed ID: 36268736

Doi: 10.2807/1560-7917.ES.2022.27.42.2101057

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Upregulation of programmed cell death 1 by interferon gamma and its biological functions in human monocytes

Authors: Kittitach Sri-Ngern-Ngam, Pornlapat Keawvilai, Trairak Pisitkun, Tanapat Palaga

Journal: Biochem Biophys Rep

PubMed ID: 36275930

Doi: 10.1016/j.bbrep.2022.101369

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Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage

Authors: Qianying Lv, Xinli Han, Jiajia Ni, Qianqian Ma, Rufeng Dai, Jiaojiao Liu, Jialu Liu, Yihui Zhai, Qian Shen, Li Sun, Haimei Liu, Jia Rao, Hong Xu

Journal: Cell Death Dis

PubMed ID: 36229446

Doi: 10.1038/s41419-022-05313-7

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On the role of cell surface associated, mucin-like glycoproteins in the pennate diatom Craspedostauros australis (Bacillariophyceae)

Authors: Nicole Poulsen, Helene Hennig, Veikko F Geyer, Stefan Diez, Richard Wetherbee, Sorel Fitz-Gibbon, Matteo Pellegrini, Nils Kröger

Journal: J Phycol

PubMed ID: 36199194

Doi: 10.1111/jpy.13287

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A critical path to producing high quality, reproducible data from quantitative western blot experiments

Authors: Sean C Taylor, Luciana K Rosselli-Murai, Bélinda Crobeddu, Isabelle Plante

Journal: Sci Rep

PubMed ID: 36266411

Doi: 10.1038/s41598-022-22294-x

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Transient State Kinetics of Apicoplast DNA Polymerase Suggests the Involvement of Accessory Factors for Efficient and Accurate DNA Synthesis

Authors: Anamika Kumari, Anjali Yadav, Indrajit Lahiri

Journal: Biochemistry

PubMed ID: 36251801

Doi: 10.1021/acs.biochem.2c00446

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A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction

Authors: John T Happ, Corvin D Arveseth, Jessica Bruystens, Daniela Bertinetti, Isaac B Nelson, Cristina Olivieri, Jingyi Zhang, Danielle S Hedeen, Ju-Fen Zhu, Jacob L Capener, Jan W Bröckel, Lily Vu, C C King, Victor L Ruiz-Perez, Xuecai Ge, Gianluigi Veglia, Friedrich W Herberg, Susan S Taylor, Benjamin R Myers

Journal: Nat Struct Mol Biol

PubMed ID: 36202993

Doi: 10.1038/s41594-022-00838-z

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GITRL impairs the immunosuppressive function of MDSCs via PTEN-mediated signaling pathway in experimental Sjögren syndrome

Authors: Jie Tian, Beibei Zhang, Qingfang Yuan, Xueqing Sun, Na Peng, Bo Zhu, Chang Liu, Xiaoran Wang, Man Han, Meng Cao, Fan Xiao, Shengjun Wang, Ke Rui, Liwei Lu

Journal: Inflamm Res

PubMed ID: 36301339

Doi: 10.1007/s00011-022-01660-5

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An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation

Authors: Merve Avar, Daniel Heinzer, Alana M Thackray, Yingjun Liu, Marian Hruska-Plochan, Stefano Sellitto, Elke Schaper, Daniel P Pease, Jiang-An Yin, Asvin Kk Lakkaraju, Marc Emmenegger, Marco Losa, Andra Chincisan, Simone Hornemann, Magdalini Polymenidou, Raymond Bujdoso, Adriano Aguzzi

Journal: EMBO J

PubMed ID: 36254605

Doi: 10.15252/embj.2022112338

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Priming conditions shape breadth of neutralizing antibody responses to sarbecoviruses

Authors: Janice Zhirong Jia, Chee Wah Tan, Samuel M S Cheng, Haogao Gu, Aileen Ying Yan Yeoh, Chris Ka Pun Mok, Yanqun Wang, Jincun Zhao, Nancy H L Leung, Benjamin J Cowling, Leo L M Poon, David S C Hui, Linfa Wang, Malik Peiris, Sophie A Valkenburg

Journal: Nat Commun

PubMed ID: 36271047

Doi: 10.1038/s41467-022-34038-6

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Inhibition of Glypican-3 Cleavage Results in Reduced Cell Proliferation in a Liver Cancer Cell Line

Authors: Emily J Schepers, Charissa Lake, Kathryn Glaser, Alexander J Bondoc

Journal: J Surg Res

PubMed ID: 36272230

Doi: 10.1016/j.jss.2022.09.011

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Discovery and functional characterization of the oncogenicity and targetability of a novel gene fusion in pediatric angiosarcoma

Authors: Payal Jain, Sudarshan Iyer, Joshua Straka, Lea F Surrey, Jennifer Pogoriler, Harry Han, Tiffany Smith, Christine Busch, Elizabeth Fox, Marilyn Li, Angela J Waanders, Adam Resnick, Monika A Davare

Journal: Cold Spring Harb Mol Case Stud

PubMed ID: 36307212

Doi: 10.1101/mcs.a006222

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A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers

Authors: Rongjie Cheng, Fanying Li, Maolei Zhang, Xin Xia, Jianzhuang Wu, Xinya Gao, Huangkai Zhou, Zhi Zhang, Nunu Huang, Xuesong Yang, Yaliang Zhang, Shunli Shen, Tiebang Kang, Zexian Liu, Feizhe Xiao, Hongwei Yao, Jianbo Xu, Chao Yan, Nu Zhang

Journal: Cell Res

PubMed ID: 36241718

Doi: 10.1038/s41422-022-00726-7

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Comparative proteomic analysis reveals novel insights into the continuous cropping induced response in Scrophularia ningpoensis

Authors: Jiachen Sun, Xuejiao Li, Zhuo Qu, Huairui Wang, Yao Cheng, Shengjie Dong, Hui Zhao

Journal: J Sci Food Agric

PubMed ID: 36271763

Doi: 10.1002/jsfa.12284

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A dataset comprised of binding interactions for 104,972 antibodies against a SARS-CoV-2 peptide

Authors: Emily Engelhart, Ryan Emerson, Leslie Shing, Chelsea Lennartz, Daniel Guion, Mary Kelley, Charles Lin, Randolph Lopez, David Younger, Matthew E Walsh

Journal: Sci Data

PubMed ID: 36289234

Doi: 10.1038/s41597-022-01779-4

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Autophagic flux restoration enhances the antitumor efficacy of tumor infiltrating lymphocytes

Authors: Chaoting Zhang, Yizhe Sun, Shance Li, Luyan Shen, Xia Teng, Yefei Xiao, Nan Wu, Zheming Lu

Journal: J Immunother Cancer

PubMed ID: 36307150

Doi: 10.1136/jitc-2022-004868

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ICG-Dimeric Her2-Specific Affibody Conjugates for Tumor Imaging and Photothermal Therapy for Her2-Positive Tumors

Authors: Dianlong Jia, Huimin Liu, Shuhui Zheng, Dandan Yuan, Ruohan Sun, Fei Wang, Yang Li, Hui Li, Fengjiao Yuan, Qing Fan, Zhenxiong Zhao

Journal: Mol Pharm

PubMed ID: 36315025

Doi: 10.1021/acs.molpharmaceut.2c00708

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