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Comparison of the immunogenicity of five COVID-19 vaccines in Sri Lanka

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Saubhagya Danasekara, Laksiri Gomes, Suranga Fernando, Dinuka Guruge, Thushali Ranasinghe, Banuri Gunasekera, Achala Kamaladasa, Heshan Kuruppu, Gayasha Somathilake, Jeewantha Jayamali, Deshni Jayathilaka, Helanka Dinesh Kumara Wijayatilake, Pradeep Darshana Pushpakumara, Michael Harvie, Thashmi Nimasha, Shiromi Devika Grace de Silva, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Jack Tan, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: Immunology

PubMed ID: 35751563

Doi: 10.1111/imm.13535

Products & Services: Recombinant Antibody Expression

Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins

Authors: David Moi, Shunsuke Nishio, Xiaohui Li, Clari Valansi, Mauricio Langleib, Nicolas G Brukman, Kateryna Flyak, Christophe Dessimoz, Daniele de Sanctis, Kathryn Tunyasuvunakool, John Jumper, Martin Graña, Héctor Romero, Pablo S Aguilar, Luca Jovine, Benjamin Podbilewicz

Journal: Nat Commun

PubMed ID: 35794124

Doi: 10.1038/s41467-022-31564-1

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A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes

Authors: Khyati Girdhar, Qian Huang, I-Ting Chow, Tommi Vatanen, Claudia Brady, Amol Raisingani, Patrick Autissier, Mark A Atkinson, William W Kwok, C Ronald Kahn, Emrah Altindis

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35878027

Doi: 10.1073/pnas.2120028119

Products & Services: Proteins, Expression, Isolation and Analysis

Anti-Ischemic Effects of PIK3IP1 Are Mediated through Its Interactions with the ET-PI3Kγ-AKT Axis

Authors: Jei Hyoung Park, Kyoung Jin Nho, Ji Young Lee, Yung Joon Yoo, Woo Jin Park, Chunghee Cho, Do Han Kim

Journal: Cells

PubMed ID: 35883611

Doi: 10.3390/cells11142162

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Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission

Authors: Sash Lopaticki, Robyn McConville, Alan John, Niall Geoghegan, Shihab Deen Mohamed, Lisa Verzier, Ryan W J Steel, Cindy Evelyn, Matthew T O'Neill, Niccolay Madiedo Soler, Nichollas E Scott, Kelly L Rogers, Ethan D Goddard-Borger, Justin A Boddey

Journal: Nat Commun

PubMed ID: 35906227

Doi: 10.1038/s41467-022-32076-8

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Inactive and active state structures template selective tools for the human 5-HT receptor

Authors: Shicheng Zhang, He Chen, Chengwei Zhang, Ying Yang, Petr Popov, Jing Liu, Brian E Krumm, Can Cao, Kuglae Kim, Yan Xiong, Vsevolod Katritch, Brian K Shoichet, Jian Jin, Jonathan F Fay, Bryan L Roth

Journal: Nat Struct Mol Biol

PubMed ID: 35835867

Doi: 10.1038/s41594-022-00796-6

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 Delta spike protein enhances the viral fusogenicity and inflammatory cytokine production

Authors: Zhujun Ao, Maggie Jing Ouyang, Titus Abiola Olukitibi, Xiaojian Yao

Journal: iScience

PubMed ID: 35854977

Doi: 10.1016/j.isci.2022.104759

Products & Services: Plasmid DNA Preparation

gC1qR/C1qBP/HABP-1: Structural Analysis of the Trimeric Core Region, Interactions With a Novel Panel of Monoclonal Antibodies, and Their Influence on Binding to FXII

Authors: Ying Zhang, Alexander J Vontz, Ethan M Kallenberger, Xin Xu, Nicoleta T Ploscariu, Kasra X Ramyar, Brandon L Garcia, Berhane Ghebrehiwet, Brian V Geisbrecht

Journal: Front Immunol

PubMed ID: 35865516

Doi: 10.3389/fimmu.2022.887742

Products & Services: Mammalian Expression

Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected Individuals

Authors: Zehra Karakoese, Mara Schwerdtfeger, Christina B Karsten, Stefan Esser, Ulf Dittmer, Kathrin Sutter

Journal: Front Immunol

PubMed ID: 35911692

Doi: 10.3389/fimmu.2022.936918

Products & Services: Mammalian Expression

Orphan nuclear receptor NUR77 relieves insulin resistance in HTR-8/SVneo trophoblast cells through activation of autophagy and insulin signaling

Authors: Ling Li, Yu Bai, Runyu Du, Lei Tang, Ling Li

Journal: J Physiol Biochem

PubMed ID: 35902547

Doi: 10.1007/s13105-022-00901-9

Products & Services: Proteins, Expression, Isolation and Analysis

Transcriptional response to VZV infection is modulated by RNA polymerase III in lung epithelial cell lines

Authors: Brianna M Doratt, Elizabeth Vance, Delphine C Malherbe, Mark T W Ebbert, Ilhem Messaoudi

Journal: Front Cell Infect Microbiol

PubMed ID: 35959363

Doi: 10.3389/fcimb.2022.943587

Products & Services: Proteins, Expression, Isolation and Analysis

Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter

Authors: Deepthi Joseph, Smruti Ranjan Nayak, Aravind Penmatsa

Journal: EMBO J

PubMed ID: 35796008

Doi: 10.15252/embj.2022110735

Products & Services: Gene Synthesis

A recombinant VSV-vectored vaccine rapidly protects nonhuman primates against heterologous lethal Lassa fever

Authors: Robert W Cross, Courtney Woolsey, Abhishek N Prasad, Viktoriya Borisevich, Krystle N Agans, Daniel J Deer, Joan B Geisbert, Natalie S Dobias, Karla A Fenton, Thomas W Geisbert

Journal: Cell Rep

PubMed ID: 35858566

Doi: 10.1016/j.celrep.2022.111094

Products & Services: Peptide Synthesis

Low molecular weight fucoidan alleviates cerebrovascular damage by promoting angiogenesis in type 2 diabetes mice

Authors: Zhi Li, Ning Wu, Jing Wang, Yang Yue, Lihua Geng, Quanbin Zhang

Journal: Int J Biol Macromol

PubMed ID: 35841956

Doi: doi.org/10.1016/j.ijbiomac.2022.07.053

Products & Services: Proteins, Expression, Isolation and Analysis

Structural insight into apelin receptor-G protein stoichiometry

Authors: Yang Yue , Lier Liu , Li-Jie Wu , Yiran Wu , Ling Wang , Fei Li , Junlin Liu , Gye-Won Han , Bo Chen , Xi Lin , Rebecca L Brouillette , Émile Breault , Jean-Michel Longpré , Songting Shi , Hui Lei , Philippe Sarret , Raymond C Stevens , Michael A Hanson , Fei Xu

Journal: Nat Struct Mol Biol

PubMed ID: 35817871

Doi: 10.1038/s41594-022-00797-5

Products & Services: Peptide Synthesis

Endothelial PHD2 deficiency induces nitrative stress suppression of caveolin-1 in pulmonary hypertension

Authors: Bin Liu, Yi Peng, Dan Yi, Narsa Machireddy, Daoyin Dong, Karina Ramirez, Jingbo Dai, Rebecca Vanderpool, Maggie M Zhu, Zhiyu Dai, You-Yang Zhao

Journal: Eur Respir J

PubMed ID: 35798360

Doi: 10.1183/13993003.02643-2021

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Purification, characterization, and preliminary serial crystallography diffraction advances structure determination of full-length human particulate guanylyl cyclase A receptor

Authors: Shangji Zhang, Debra T Hansen, Jose M Martin-Garcia, James D Zook, Shuchong Pan, Felicia M Craciunescu, John C Burnett, Petra Fromme

Journal: Sci Rep

PubMed ID: 35821229

Doi: 10.1038/s41598-022-15798-z

Products & Services: Insect Expression

Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes.

Authors: Uxue Ballesteros , Asier Etxaniz , Marina N Iriondo , Yaiza R Varela , Melisa Lázaro , Ana R Viguera , L Ruth Montes , Mikel Valle , Félix M Goñi , Alicia Alonso

Journal: Int J Biol Macromol

PubMed ID: 35618088

Doi: 10.1016/j.ijbiomac.2022.05.129.

Products & Services: Mutagenesis Services

Heterologous mRNA vaccine booster increases neutralization of SARS-CoV-2 Omicron BA.2 variant

Authors: Gen Li , Zhongcheng Zhou , Peng Du , Meixiao Zhan , Ning Li 1、, Xinxin Xiong , Shengjun Tang , Miao Man, Daniel T Baptista-Hon, Ligong Lu

Journal: Signal Transduct Target Ther

PubMed ID: 35853864

Doi: 10.1038/s41392-022-01062-3.

Products & Services: Gene Synthesis

Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions

Authors: Xingxing Li , Liuqing He , Jianhua Luo , Yangling Zheng , Yao Zhou , Danyang Li , Yuanyuan Zhang , Zhenrui Pan , Yanyan Li , Liang Tao

Journal: Nat Commun

PubMed ID: 35882856

Doi: 10.1038/s41467-022-31994-x

Products & Services: Gene Synthesis Monoclonal Antibody Services

Effective Functional Immunogenicity of a DNA Vaccine Combination Delivered via In Vivo Electroporation Targeting Malaria Infection and Transmission

Authors: Yi Cao , Clifford T H Hayashi , Fidel Zavala , Abhai K Tripathi , Hayk Simonyan , Colin N Young , Leor C Clark , Yukari Usuda , Jacob M Van Parys , Nirbhay Kumar

Journal: Vaccines (Basel)

PubMed ID: 35891298

Doi: 10.3390/vaccines10071134

Products & Services: Plasmid DNA Preparation

One-pot isothermal LAMP-CRISPR-based assay for Klebsiella pneumoniae detection

Authors: Xiaotong Qiu , Xueping Liu , Xiao Ma , Ruixue Wang , Shenglin Chen , Fang Li , Zhenjun Li

Journal: Microbiol Spectr

PubMed ID: 35856669

Doi: 10.1128/spectrum.01545-22

Products & Services: Synthetic sgRNA and crRNA Service

Direct adenylation from 5?-OH-terminated oligonucleotides by a fusion enzyme containing Pfu RNA ligase and T4 polynucleotide kinase

Authors: Zhengquan Yang , Chengliang Zhang , Guojun Lian , Shijie Dong , Menghui Song , Hengrong Shao , Jingmei Wang , Tao Zhong , Zhenni Luo , Shengnan Jin , Chunming Ding

Journal: Nucleic Acids Res

PubMed ID: 35819229

Doi: org/10.1093/nar/gkac604

Products & Services: Custom DNA/RNA Oligos

Structural insights into the activation of neurokinin 2 receptor by neurokinin A

Authors: Wenjing Sun , Qingning Yuan , Huanhuan Zhang , Fan Yang , Shenglong Ling , Yifan Luo , Pei Lv , H Eric Xu , Changlin Tian , Wanchao Yin , Pan Shi

Journal: Cell Discov

PubMed ID: 35882833

Doi: 10.1038/s41421-022-00437-8

Products & Services: Gene Synthesis

Discrimination between Different DNA Lesions by Monitoring Single-Molecule Polymerase Stalling Kinetics during Nanopore Sequencing

Authors: Jinyue Zhang , Yu Wang , Yuqin Wang , Panke Zhang , Hong-Yuan Chen , Shuo Huang

Journal: Nano Lett

PubMed ID: 35713465

Doi: 10.1021/acs.nanolett.2c01833

Products & Services: Custom DNA/RNA Oligos

Development of a Multi-Epitope Vaccine for and Evaluation of Its Immune Responses in Mice and Piglets

Authors: Gaojian Li, Jinqi Shu, Jing Jin, Jianhong Shu, Huapeng Feng, Jian Chen, Yulong He

Journal: Int J Mol Sci

PubMed ID: 35887246

Doi: 10.3390/ijms23147899

Products & Services: Codon Optimization

A cell-free paper-based biosensor dependent on allosteric transcription factors (aTFs) for on-site detection of harmful metals Hg and Pb in water

Authors: Yongkang Zhang, Chen Zhao, Huaixiu Bi, Xi Zhang, Bin Xue, Chenyu Li, Shang Wang, Xiaobo Yang, Zhigang Qiu, Jingfeng Wang, Zhiqiang Shen

Journal: J Hazard Mater

PubMed ID: 35816794

Doi: 10.1016/j.jhazmat.2022.129499

Products & Services: Plasmid DNA Preparation

BioWF: A Naturally-Fused, Di-Domain Biocatalyst from Biotin Biosynthesis Displays an Unexpectedly Broad Substrate Scope

Authors: Shona M Richardson, Peter J Harrison, Michael A Herrera, Menglu Wang, Rebecca Verez, Gustavo Perez Ortiz, Dominic J Campopiano

Journal: Chembiochem

PubMed ID: 35695820

Doi: 10.1002/cbic.202200171

Products & Services: Plasmid DNA Preparation

PLAA suppresses ovarian cancer metastasis via METTL3-mediated mA modification of TRPC3 mRNA

Authors: Zhangjin Shen, Lingkai Gu, Yuwan Liu, Lingfang Wang, Jiawei Zhu, Sangsang Tang, Xinyi Wei, Jiaying Wang, Songfa Zhang, Xinyu Wang, Xiaodong Cheng, Xing Xie, Weiguo Lu

Journal: Oncogene

PubMed ID: 35869392

Doi: 10.1038/s41388-022-02411-w

Products & Services: Proteins, Expression, Isolation and Analysis

Membrane Permeabilization and Antimicrobial Activity of Recombinant Defensin-d2 and Actifensin against Multidrug-Resistant and

Authors: Ifeoluwa D Gbala, Rosaline W Macharia, Joel L Bargul, Gabriel Magoma

Journal: Molecules

PubMed ID: 35889198

Doi: 10.3390/molecules27144325

Products & Services: Plasmid DNA Preparation

Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells

Authors: Dave Francisco, Ying Wang, Craig Marshall, Michelle Conway, Kenneth J Addison, Dean Billheimer, Hiroki Kimura, Mari Numata, Hong W Chu, Dennis R Voelker, Monica Kraft, Julie G Ledford

Journal: Front Immunol

PubMed ID: 35874703

Doi: 10.3389/fimmu.2022.900022

Products & Services: Catalog Peptides

Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis

Authors: Clint M Upchurch, Scott Yeudall, Caitlin M Pavelec, Dennis Merk, Jan Greulich, Mohan Manjegowda, Shyam S Raghavan, Irina M Bochkis, Michael M Scott, Edward Perez-Reyes, Norbert Leitinger

Journal: Sci Adv

PubMed ID: 35857497

Doi: 10.1126/sciadv.abn0050

Products & Services: Gene Synthesis

A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis

Authors: Namrata Bora-Singhal, Biswarup Saha, Durairaj Mohankumar, Jaya Padmanabhan, Domenico Coppola, Srikumar Chellappan

Journal: Cancer Res Commun

PubMed ID: 35937460

Doi: 10.1158/2767-9764.crc-21-0084

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Assessment of neutralizing antibody responses after natural SARS-CoV-2 infection and vaccination in congolese individuals

Authors: Armel Landry Batchi-Bouyou, Jean Claude Djontu, Jeannhey Christevy Vouvoungui, Claujens Chastel Mfoutou Mapanguy, Line Lobaloba Ingoba, Jiré Séphora Mougany, Kamal Rauchelvy Boumpoutou, Steve Diafouka-Kietela, Raoul Ampa, Francine Ntoumi

Journal: BMC Infect Dis

PubMed ID: 35831798

Doi: 10.1186/s12879-022-07593-y

Products & Services: Recombinant Proteins

The two-domain elevator-type mechanism of zinc-transporting ZIP proteins

Authors: Anders Wiuf, Jonas Hyld Steffen, Eva Ramos Becares, Christina Grønberg, Dhani Ram Mahato, Søren G F Rasmussen, Magnus Andersson, Tristan Croll, Kamil Gotfryd, Pontus Gourdon

Journal: Sci Adv

PubMed ID: 35857505

Doi: 10.1126/sciadv.abn4331

Products & Services: Mutagenesis Services

Development of Highly Sensitive Sandwich ELISA for the Early-Phase Diagnosis of Chikungunya Virus Utilizing rE2-E1 Protein

Authors: Mohammad Islamuddin, Abuzer Ali, Wajihul Hasan Khan, Amena Ali, Syed Kazim Hasan, Mohd Abdullah, Kentaro Kato, Malik Zainul Abdin, Shama Parveen

Journal: Infect Drug Resist

PubMed ID: 35924014

Doi: 10.2147/IDR.S347545

Products & Services: Gene Synthesis

Cutting Edge: Promoting T Cell Factor 1 T Cell Self-Renewal to Improve Programmed Cell Death Protein 1 Blockade

Authors: Peter H Wang, Robert Washburn, Rohan Maniar, Michael Mu, Olivia Ringham, Radomir Kratchmarov, Brian S Henick, Steven L Reiner

Journal: J Immunol

PubMed ID: 35905999

Doi: 10.4049/jimmunol.2200317

Products & Services: Mammalian Expression

Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal

Authors: Huiyun Liu, Daniel Heller-Trulli, Claire L Moore

Journal: iScience

PubMed ID: 35992060

Doi: 10.1016/j.isci.2022.104804

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Combined strategies for suppressing nonspecific cationic adduction to G-quadruplexes in electrospray ionization mass spectrometry

Authors: Wen Lei, Jun Hu, Hong-Yuan Chen, Jing-Juan Xu

Journal: Anal Chim Acta

PubMed ID: 35868693

Doi: 10.1016/j.aca.2022.340146

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Effects of SPA4 peptide on lipopolysaccharide-disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury

Authors: Asif Alam Chowdhury, Nachiket M Godbole, Neha Chataut, Stanley Kosanke, Karla Rodgers, Shanjana Awasthi

Journal: Physiol Rep

PubMed ID: 35838161

Doi: 10.14814/phy2.15353

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Generation of a Soluble African Horse Sickness Virus VP7 Protein Capable of Forming Core-like Particles

Authors: Shani Bekker, Henk Huismans, Vida van Staden

Journal: Viruses

PubMed ID: 35893692

Doi: 10.3390/v14081624

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Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance

Authors: Xinlei Zhuang, Zhe Wang, Jiansheng Fan, Xuefei Bai, Yingchun Xu, James J Chou, Tingjun Hou, Shuqing Chen, Liqiang Pan

Journal: Nat Commun

PubMed ID: 35907884

Doi: 10.1038/s41467-022-32159-6

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Proteomic Network of Antibiotic-Induced Outer Membrane Vesicles Released by Extensively Drug-Resistant Elizabethkingia anophelis

Authors: Ming-Hsien Chiang, Fang-Ju Chang, Dinesh Kumar Kesavan, Aparna Vasudevan, Huaxi Xu, Kuo-Lun Lan, Shu-Wei Huang, Hung-Sheng Shang, Yi-Ping Chuang, Ya-Sung Yang, Te-Li Chen

Journal: Microbiol Spectr

PubMed ID: 35852325

Doi: 10.1128/spectrum.00262-22

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HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics

Authors: Matthew D Surette, Nicholas Waglechner, Kalinka Koteva, Gerard D Wright

Journal: Mol Cell

PubMed ID: 35907401

Doi: 10.1016/j.molcel.2022.06.019

Products & Services: Proteins, Expression, Isolation and Analysis

CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1

Authors: Yixuan Lu, Yongxin Mu, Ju Chen, Xinyuan Guan, Ling Guo, Chuanyue Wu

Journal: Theranostics

PubMed ID: 35836803

Doi: 10.7150/thno.72365

Products & Services: Recombinant Proteins

Optimized peptide extraction method for analysis of antimicrobial peptide Kn2-7/dKn2-7 stability in human serum by LC-MS

Authors: Wen Chen, Dickson Kirui, Nancy J Millenbaugh

Journal: Future Sci OA

PubMed ID: 35909998

Doi: 10.2144/fsoa-2022-0013

Products & Services: Recombinant Proteins

Differences in Linear Epitopes of Ara h 9 Recognition in Peanut Allergic and Tolerant, Peach Allergic Patients

Authors: L Sánchez-Ruano, C Fernández-Lozano, M Ferrer, F Gómez, B de la Hoz, J Martínez-Botas, M J Goikoetxea

Journal: Front Allergy

PubMed ID: 35935018

Doi: 10.3389/falgy.2022.896617

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A multiple-target mRNA-LNP vaccine induces protective immunity against experimental multi-serotype DENV in mice

Authors: Lihong He, Wenqiang Sun, Limin Yang, Wenjun Liu, Jing Li

Journal: Virol Sin

PubMed ID: 35835315

Doi: 10.1016/j.virs.2022.07.003

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Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ

Authors: Qian Zhou, Wan-Wan Sun, Jia-Cong Chen, Hui-Lu Zhang, Jie Liu, Yan Lin, Peng-Cheng Lin, Bai-Xing Wu, Yan-Peng An, Lin Huang, Wen-Xing Sun, Xin-Wen Zhou, Yi-Ming Li, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao

Journal: Nat Commun

PubMed ID: 35879296

Doi: 10.1038/s41467-022-32000-0

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Comparing methods for immobilizing HIV-1 SOSIPs in ELISAs that evaluate antibody binding

Authors: Kim-Marie A Dam, Patricia S Mutia, Pamela J Bjorkman

Journal: Sci Rep

PubMed ID: 35778473

Doi: 10.1038/s41598-022-15506-x

Products & Services: Mammalian Expression

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