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A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes
Authors: Khyati Girdhar, Qian Huang, I-Ting Chow, Tommi Vatanen, Claudia Brady, Amol Raisingani, Patrick Autissier, Mark A Atkinson, William W Kwok, C Ronald Kahn, Emrah Altindis
Journal: Proc Natl Acad Sci U S A
PubMed ID: 35878027
Doi: 10.1073/pnas.2120028119
Anti-Ischemic Effects of PIK3IP1 Are Mediated through Its Interactions with the ET-PI3Kγ-AKT Axis
Authors: Jei Hyoung Park, Kyoung Jin Nho, Ji Young Lee, Yung Joon Yoo, Woo Jin Park, Chunghee Cho, Do Han Kim
Journal: Cells
PubMed ID: 35883611
Doi: 10.3390/cells11142162
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Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission
Authors: Sash Lopaticki, Robyn McConville, Alan John, Niall Geoghegan, Shihab Deen Mohamed, Lisa Verzier, Ryan W J Steel, Cindy Evelyn, Matthew T O'Neill, Niccolay Madiedo Soler, Nichollas E Scott, Kelly L Rogers, Ethan D Goddard-Borger, Justin A Boddey
Journal: Nat Commun
PubMed ID: 35906227
Doi: 10.1038/s41467-022-32076-8
Products & Services: Gene Synthesis   
gC1qR/C1qBP/HABP-1: Structural Analysis of the Trimeric Core Region, Interactions With a Novel Panel of Monoclonal Antibodies, and Their Influence on Binding to FXII
Authors: Ying Zhang, Alexander J Vontz, Ethan M Kallenberger, Xin Xu, Nicoleta T Ploscariu, Kasra X Ramyar, Brandon L Garcia, Berhane Ghebrehiwet, Brian V Geisbrecht
Journal: Front Immunol
PubMed ID: 35865516
Doi: 10.3389/fimmu.2022.887742
Products & Services: Mammalian Expression   
Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected Individuals
Authors: Zehra Karakoese, Mara Schwerdtfeger, Christina B Karsten, Stefan Esser, Ulf Dittmer, Kathrin Sutter
Journal: Front Immunol
PubMed ID: 35911692
Doi: 10.3389/fimmu.2022.936918
Products & Services: Mammalian Expression   
Orphan nuclear receptor NUR77 relieves insulin resistance in HTR-8/SVneo trophoblast cells through activation of autophagy and insulin signaling
Authors: Ling Li, Yu Bai, Runyu Du, Lei Tang, Ling Li
Journal: J Physiol Biochem
PubMed ID: 35902547
Doi: 10.1007/s13105-022-00901-9
Transcriptional response to VZV infection is modulated by RNA polymerase III in lung epithelial cell lines
Authors: Brianna M Doratt, Elizabeth Vance, Delphine C Malherbe, Mark T W Ebbert, Ilhem Messaoudi
Journal: Front Cell Infect Microbiol
PubMed ID: 35959363
Doi: 10.3389/fcimb.2022.943587
Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter
Authors: Deepthi Joseph, Smruti Ranjan Nayak, Aravind Penmatsa
Journal: EMBO J
PubMed ID: 35796008
Doi: 10.15252/embj.2022110735
Products & Services: Gene Synthesis   
SARS-CoV-2 Delta spike protein enhances the viral fusogenicity and inflammatory cytokine production
Authors: Zhujun Ao, Maggie Jing Ouyang, Titus Abiola Olukitibi, Xiaojian Yao
Journal: iScience
PubMed ID: 35854977
Doi: 10.1016/j.isci.2022.104759
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Inactive and active state structures template selective tools for the human 5-HT receptor
Authors: Shicheng Zhang, He Chen, Chengwei Zhang, Ying Yang, Petr Popov, Jing Liu, Brian E Krumm, Can Cao, Kuglae Kim, Yan Xiong, Vsevolod Katritch, Brian K Shoichet, Jian Jin, Jonathan F Fay, Bryan L Roth
Journal: Nat Struct Mol Biol
PubMed ID: 35835867
Doi: 10.1038/s41594-022-00796-6
A recombinant VSV-vectored vaccine rapidly protects nonhuman primates against heterologous lethal Lassa fever
Authors: Robert W Cross, Courtney Woolsey, Abhishek N Prasad, Viktoriya Borisevich, Krystle N Agans, Daniel J Deer, Joan B Geisbert, Natalie S Dobias, Karla A Fenton, Thomas W Geisbert
Journal: Cell Rep
PubMed ID: 35858566
Doi: 10.1016/j.celrep.2022.111094
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Low molecular weight fucoidan alleviates cerebrovascular damage by promoting angiogenesis in type 2 diabetes mice
Authors: Zhi Li, Ning Wu, Jing Wang, Yang Yue, Lihua Geng, Quanbin Zhang
Journal: Int J Biol Macromol
PubMed ID: 35841956
Doi: doi.org/10.1016/j.ijbiomac.2022.07.053
Structural insight into apelin receptor-G protein stoichiometry
Authors: Yang Yue , Lier Liu , Li-Jie Wu , Yiran Wu , Ling Wang , Fei Li , Junlin Liu , Gye-Won Han , Bo Chen , Xi Lin , Rebecca L Brouillette , Émile Breault , Jean-Michel Longpré , Songting Shi , Hui Lei , Philippe Sarret , Raymond C Stevens , Michael A Hanson , Fei Xu
Journal: Nat Struct Mol Biol
PubMed ID: 35817871
Doi: 10.1038/s41594-022-00797-5
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Endothelial PHD2 deficiency induces nitrative stress suppression of caveolin-1 in pulmonary hypertension
Authors: Bin Liu, Yi Peng, Dan Yi, Narsa Machireddy, Daoyin Dong, Karina Ramirez, Jingbo Dai, Rebecca Vanderpool, Maggie M Zhu, Zhiyu Dai, You-Yang Zhao
Journal: Eur Respir J
PubMed ID: 35798360
Doi: 10.1183/13993003.02643-2021
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Purification, characterization, and preliminary serial crystallography diffraction advances structure determination of full-length human particulate guanylyl cyclase A receptor
Authors: Shangji Zhang, Debra T Hansen, Jose M Martin-Garcia, James D Zook, Shuchong Pan, Felicia M Craciunescu, John C Burnett, Petra Fromme
Journal: Sci Rep
PubMed ID: 35821229
Doi: 10.1038/s41598-022-15798-z
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Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes.
Authors: Uxue Ballesteros , Asier Etxaniz , Marina N Iriondo , Yaiza R Varela , Melisa Lázaro , Ana R Viguera , L Ruth Montes , Mikel Valle , Félix M Goñi , Alicia Alonso
Journal: Int J Biol Macromol
PubMed ID: 35618088
Doi: 10.1016/j.ijbiomac.2022.05.129.
Products & Services: Mutagenesis Services   
Heterologous mRNA vaccine booster increases neutralization of SARS-CoV-2 Omicron BA.2 variant
Authors: Gen Li , Zhongcheng Zhou , Peng Du , Meixiao Zhan , Ning Li 1、, Xinxin Xiong , Shengjun Tang , Miao Man, Daniel T Baptista-Hon, Ligong Lu
Journal: Signal Transduct Target Ther
PubMed ID: 35853864
Doi: 10.1038/s41392-022-01062-3.
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Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions
Authors: Xingxing Li , Liuqing He , Jianhua Luo , Yangling Zheng , Yao Zhou , Danyang Li , Yuanyuan Zhang , Zhenrui Pan , Yanyan Li , Liang Tao
Journal: Nat Commun
PubMed ID: 35882856
Doi: 10.1038/s41467-022-31994-x
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Effective Functional Immunogenicity of a DNA Vaccine Combination Delivered via In Vivo Electroporation Targeting Malaria Infection and Transmission
Authors: Yi Cao , Clifford T H Hayashi , Fidel Zavala , Abhai K Tripathi , Hayk Simonyan , Colin N Young , Leor C Clark , Yukari Usuda , Jacob M Van Parys , Nirbhay Kumar
Journal: Vaccines (Basel)
PubMed ID: 35891298
Doi: 10.3390/vaccines10071134
Products & Services: Plasmid DNA Preparation   
One-pot isothermal LAMP-CRISPR-based assay for Klebsiella pneumoniae detection
Authors: Xiaotong Qiu , Xueping Liu , Xiao Ma , Ruixue Wang , Shenglin Chen , Fang Li , Zhenjun Li
Journal: Microbiol Spectr
PubMed ID: 35856669
Doi: 10.1128/spectrum.01545-22
Products & Services: Synthetic sgRNA and crRNA Service   
Direct adenylation from 5?-OH-terminated oligonucleotides by a fusion enzyme containing Pfu RNA ligase and T4 polynucleotide kinase
Authors: Zhengquan Yang , Chengliang Zhang , Guojun Lian , Shijie Dong , Menghui Song , Hengrong Shao , Jingmei Wang , Tao Zhong , Zhenni Luo , Shengnan Jin , Chunming Ding
Journal: Nucleic Acids Res
PubMed ID: 35819229
Doi: org/10.1093/nar/gkac604
Products & Services: Custom DNA/RNA Oligos   
Structural insights into the activation of neurokinin 2 receptor by neurokinin A
Authors: Wenjing Sun , Qingning Yuan , Huanhuan Zhang , Fan Yang , Shenglong Ling , Yifan Luo , Pei Lv , H Eric Xu , Changlin Tian , Wanchao Yin , Pan Shi
Journal: Cell Discov
PubMed ID: 35882833
Doi: 10.1038/s41421-022-00437-8
Products & Services: Gene Synthesis   
Discrimination between Different DNA Lesions by Monitoring Single-Molecule Polymerase Stalling Kinetics during Nanopore Sequencing
Authors: Jinyue Zhang , Yu Wang , Yuqin Wang , Panke Zhang , Hong-Yuan Chen , Shuo Huang
Journal: Nano Lett
PubMed ID: 35713465
Doi: 10.1021/acs.nanolett.2c01833
Products & Services: Custom DNA/RNA Oligos   
Generation of a Soluble African Horse Sickness Virus VP7 Protein Capable of Forming Core-like Particles
Authors: Shani Bekker, Henk Huismans, Vida van Staden
Journal: Viruses
PubMed ID: 35893692
Doi: 10.3390/v14081624
Products & Services: Polyclonal Antibody Services   
Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance
Authors: Xinlei Zhuang, Zhe Wang, Jiansheng Fan, Xuefei Bai, Yingchun Xu, James J Chou, Tingjun Hou, Shuqing Chen, Liqiang Pan
Journal: Nat Commun
PubMed ID: 35907884
Doi: 10.1038/s41467-022-32159-6
Products & Services: Polyclonal Antibody Services   
Effects of SPA4 peptide on lipopolysaccharide-disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury
Authors: Asif Alam Chowdhury, Nachiket M Godbole, Neha Chataut, Stanley Kosanke, Karla Rodgers, Shanjana Awasthi
Journal: Physiol Rep
PubMed ID: 35838161
Doi: 10.14814/phy2.15353
Products & Services: Peptide Synthesis   
Humanin derivative, HNG, enhances neurotransmitter release
Authors: Natsumi Ikegawa, Ayari Kozuka, Nozomi Morita, Minetaka Murakami, Nobuyuki Sasakawa, Takako Niikura
Journal: Biochim Biophys Acta Gen Subj
PubMed ID: 35843407
Doi: 10.1016/j.bbagen.2022.130204
Products & Services: Endotoxin Detection & Removal System   
Development of a Multi-Epitope Vaccine for and Evaluation of Its Immune Responses in Mice and Piglets
Authors: Gaojian Li, Jinqi Shu, Jing Jin, Jianhong Shu, Huapeng Feng, Jian Chen, Yulong He
Journal: Int J Mol Sci
PubMed ID: 35887246
Doi: 10.3390/ijms23147899
Products & Services: Codon Optimization   
BioWF: A Naturally-Fused, Di-Domain Biocatalyst from Biotin Biosynthesis Displays an Unexpectedly Broad Substrate Scope
Authors: Shona M Richardson, Peter J Harrison, Michael A Herrera, Menglu Wang, Rebecca Verez, Gustavo Perez Ortiz, Dominic J Campopiano
Journal: Chembiochem
PubMed ID: 35695820
Doi: 10.1002/cbic.202200171
Products & Services: Plasmid DNA Preparation   
A cell-free paper-based biosensor dependent on allosteric transcription factors (aTFs) for on-site detection of harmful metals Hg and Pb in water
Authors: Yongkang Zhang, Chen Zhao, Huaixiu Bi, Xi Zhang, Bin Xue, Chenyu Li, Shang Wang, Xiaobo Yang, Zhigang Qiu, Jingfeng Wang, Zhiqiang Shen
Journal: J Hazard Mater
PubMed ID: 35816794
Doi: 10.1016/j.jhazmat.2022.129499
Products & Services: Plasmid DNA Preparation   
PLAA suppresses ovarian cancer metastasis via METTL3-mediated mA modification of TRPC3 mRNA
Authors: Zhangjin Shen, Lingkai Gu, Yuwan Liu, Lingfang Wang, Jiawei Zhu, Sangsang Tang, Xinyi Wei, Jiaying Wang, Songfa Zhang, Xinyu Wang, Xiaodong Cheng, Xing Xie, Weiguo Lu
Journal: Oncogene
PubMed ID: 35869392
Doi: 10.1038/s41388-022-02411-w
Membrane Permeabilization and Antimicrobial Activity of Recombinant Defensin-d2 and Actifensin against Multidrug-Resistant and
Authors: Ifeoluwa D Gbala, Rosaline W Macharia, Joel L Bargul, Gabriel Magoma
Journal: Molecules
PubMed ID: 35889198
Doi: 10.3390/molecules27144325
Products & Services: Plasmid DNA Preparation   
Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells
Authors: Dave Francisco, Ying Wang, Craig Marshall, Michelle Conway, Kenneth J Addison, Dean Billheimer, Hiroki Kimura, Mari Numata, Hong W Chu, Dennis R Voelker, Monica Kraft, Julie G Ledford
Journal: Front Immunol
PubMed ID: 35874703
Doi: 10.3389/fimmu.2022.900022
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Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis
Authors: Clint M Upchurch, Scott Yeudall, Caitlin M Pavelec, Dennis Merk, Jan Greulich, Mohan Manjegowda, Shyam S Raghavan, Irina M Bochkis, Michael M Scott, Edward Perez-Reyes, Norbert Leitinger
Journal: Sci Adv
PubMed ID: 35857497
Doi: 10.1126/sciadv.abn0050
Products & Services: Gene Synthesis   
A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis
Authors: Namrata Bora-Singhal, Biswarup Saha, Durairaj Mohankumar, Jaya Padmanabhan, Domenico Coppola, Srikumar Chellappan
Journal: Cancer Res Commun
PubMed ID: 35937460
Doi: 10.1158/2767-9764.crc-21-0084
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Assessment of neutralizing antibody responses after natural SARS-CoV-2 infection and vaccination in congolese individuals
Authors: Armel Landry Batchi-Bouyou, Jean Claude Djontu, Jeannhey Christevy Vouvoungui, Claujens Chastel Mfoutou Mapanguy, Line Lobaloba Ingoba, Jiré Séphora Mougany, Kamal Rauchelvy Boumpoutou, Steve Diafouka-Kietela, Raoul Ampa, Francine Ntoumi
Journal: BMC Infect Dis
PubMed ID: 35831798
Doi: 10.1186/s12879-022-07593-y
Products & Services: Recombinant Proteins   
The two-domain elevator-type mechanism of zinc-transporting ZIP proteins
Authors: Anders Wiuf, Jonas Hyld Steffen, Eva Ramos Becares, Christina Grønberg, Dhani Ram Mahato, Søren G F Rasmussen, Magnus Andersson, Tristan Croll, Kamil Gotfryd, Pontus Gourdon
Journal: Sci Adv
PubMed ID: 35857505
Doi: 10.1126/sciadv.abn4331
Products & Services: Mutagenesis Services   
Development of Highly Sensitive Sandwich ELISA for the Early-Phase Diagnosis of Chikungunya Virus Utilizing rE2-E1 Protein
Authors: Mohammad Islamuddin, Abuzer Ali, Wajihul Hasan Khan, Amena Ali, Syed Kazim Hasan, Mohd Abdullah, Kentaro Kato, Malik Zainul Abdin, Shama Parveen
Journal: Infect Drug Resist
PubMed ID: 35924014
Doi: 10.2147/IDR.S347545
Products & Services: Gene Synthesis   
Cutting Edge: Promoting T Cell Factor 1 T Cell Self-Renewal to Improve Programmed Cell Death Protein 1 Blockade
Authors: Peter H Wang, Robert Washburn, Rohan Maniar, Michael Mu, Olivia Ringham, Radomir Kratchmarov, Brian S Henick, Steven L Reiner
Journal: J Immunol
PubMed ID: 35905999
Doi: 10.4049/jimmunol.2200317
Products & Services: Mammalian Expression   
Proteomic Network of Antibiotic-Induced Outer Membrane Vesicles Released by Extensively Drug-Resistant Elizabethkingia anophelis
Authors: Ming-Hsien Chiang, Fang-Ju Chang, Dinesh Kumar Kesavan, Aparna Vasudevan, Huaxi Xu, Kuo-Lun Lan, Shu-Wei Huang, Hung-Sheng Shang, Yi-Ping Chuang, Ya-Sung Yang, Te-Li Chen
Journal: Microbiol Spectr
PubMed ID: 35852325
Doi: 10.1128/spectrum.00262-22
Products & Services: Bacterial Expression   
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics
Authors: Matthew D Surette, Nicholas Waglechner, Kalinka Koteva, Gerard D Wright
Journal: Mol Cell
PubMed ID: 35907401
Doi: 10.1016/j.molcel.2022.06.019
Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal
Authors: Huiyun Liu, Daniel Heller-Trulli, Claire L Moore
Journal: iScience
PubMed ID: 35992060
Doi: 10.1016/j.isci.2022.104804
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Combined strategies for suppressing nonspecific cationic adduction to G-quadruplexes in electrospray ionization mass spectrometry
Authors: Wen Lei, Jun Hu, Hong-Yuan Chen, Jing-Juan Xu
Journal: Anal Chim Acta
PubMed ID: 35868693
Doi: 10.1016/j.aca.2022.340146
Products & Services: Custom DNA/RNA Oligos   
Optimized peptide extraction method for analysis of antimicrobial peptide Kn2-7/dKn2-7 stability in human serum by LC-MS
Authors: Wen Chen, Dickson Kirui, Nancy J Millenbaugh
Journal: Future Sci OA
PubMed ID: 35909998
Doi: 10.2144/fsoa-2022-0013
Products & Services: Recombinant Proteins   
CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1
Authors: Yixuan Lu, Yongxin Mu, Ju Chen, Xinyuan Guan, Ling Guo, Chuanyue Wu
Journal: Theranostics
PubMed ID: 35836803
Doi: 10.7150/thno.72365
Products & Services: Recombinant Proteins   
A multiple-target mRNA-LNP vaccine induces protective immunity against experimental multi-serotype DENV in mice
Authors: Lihong He, Wenqiang Sun, Limin Yang, Wenjun Liu, Jing Li
Journal: Virol Sin
PubMed ID: 35835315
Doi: 10.1016/j.virs.2022.07.003
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Comparing methods for immobilizing HIV-1 SOSIPs in ELISAs that evaluate antibody binding
Authors: Kim-Marie A Dam, Patricia S Mutia, Pamela J Bjorkman
Journal: Sci Rep
PubMed ID: 35778473
Doi: 10.1038/s41598-022-15506-x
Products & Services: Mammalian Expression   
A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding
Authors: Brooke D Huisman, Zheng Dai, David K Gifford, Michael E Birnbaum
Journal: Elife
PubMed ID: 35781135
Doi: 10.7554/eLife.78589
Products & Services: Recombinant Antibody Expression   
Pneumolysin suppresses the initial macrophage pro-inflammatory response to Streptococcus pneumoniae
Authors: Jimstan Periselneris, Carolin T Turner, Giuseppe Ercoli, Gabriella Szylar, Caroline M Weight, Teresa Thurston, Matthew Whelan, Gillian Tomlinson, Mahdad Noursadeghi, Jeremy Brown
Journal: Immunology
PubMed ID: 35835695
Doi: 10.1111/imm.13546
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