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Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties

Authors: Hannah N Corman, Jessica N Ross, Francisco R Fields, Douglas A Shoue, Shaun W Lee, Mary Ann McDowell

Journal: Microbiol Spectr

PubMed ID: 36342284

Doi: 10.1128/spectrum.02658-22

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Pathogenic Interleukin-10 Receptor Alpha Variants in Humans - Balancing Natural Selection and Clinical Implications

Authors: Dominik Aschenbrenner, Ziqing Ye, Ying Zhou, Wenhui Hu, Isabel Brooks, Isabelle Williams, Melania Capitani, Lisa Gartner, Daniel Kotlarz, Scott B Snapper, Christoph Klein, Aleixo M Muise, Brian D Marsden, Ying Huang, Holm H Uhlig

Journal: J Clin Immunol

PubMed ID: 36370291

Doi: 10.1007/s10875-022-01366-7

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An engineered (CAGA)-EGFP cell-based biosensor for high-content and accurate detection of active TGF-β

Authors: Qian Ruan, Xuezhen Lin, Lixia Wang, Niu Wang, Yu Zhao, Hao Wang, Fu-Ying Tian, Ning Hu, Ying Li, Bo Zhao

Journal: Biosens Bioelectron

PubMed ID: 36403492

Doi: 10.1016/j.bios.2022.114884

Products & Services: Protein and Antibody Isolation

Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism

Authors: Jie Shen, Qian Zha, Qian-Hua Yang, Yue-Qian Zhou, Xiao Liang, Ying-Jie Chen, Gui-Xia Qi, Xiao-Jin Zhang, Wen-Bing Yao, Xiang-Dong Gao, Song Chen

Journal: Acta Pharmacol Sin

PubMed ID: 36357669

Doi: 10.1038/s41401-022-01014-1

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Sustained Activation of CLR/RAMP Receptors by Gel-Forming Agonists

Authors: Chia Lin Chang, Zheqing Cai, Sheau Yu Teddy Hsu

Journal: Int J Mol Sci

PubMed ID: 36362188

Doi: 10.3390/ijms232113408

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Structure-based engineering of minimal Proline dehydrogenase domains for inhibitor discovery

Authors: Alexandra N Bogner, Juan Ji, John J Tanner

Journal: Protein Eng Des Sel

PubMed ID: 36448708

Doi: 10.1093/protein/gzac016

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The effect of mutations on binding interactions between the SARS-CoV-2 receptor binding domain and neutralizing antibodies B38 and CB6

Authors: Jonathan E Barnes, Peik K Lund-Andersen, Jagdish Suresh Patel, F Marty Ytreberg

Journal: Sci Rep

PubMed ID: 36335244

Doi: 10.1038/s41598-022-23482-5

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Design and optimization of enzymatic activity in a de novo β-barrel scaffold

Authors: Yakov Kipnis, Anissa Ouald Chaib, Anastassia A Vorobieva, Guangyang Cai, Gabriella Reggiano, Benjamin Basanta, Eshan Kumar, Peer R E Mittl, Donald Hilvert, David Baker

Journal: Protein Sci

PubMed ID: 36305767

Doi: 10.1002/pro.4405

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Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomes

Authors: Neil Berry, Deborah Ferguson, Sarah Kempster, Jo Hall, Claire Ham, Adrian Jenkins, Vicky Rannow, Elaine Giles, Rose Leahy, Sara Goulding, Arturo Fernandez, Yemisi Adedeji, Sandrine Vessillier, Deepa Rajagopal, Sandra Prior, Yann Le Duff, Matthew Hurley, Sarah Gilbert, Martin Fritzsche, Ryan Mate, Nicola Rose, Robert J Francis, Kirsty MacLellan-Gibson, Alejandro Suarez-Bonnet, Simon Priestnall, Neil Almond

Journal: Sci Rep

PubMed ID: 36333445

Doi: 10.1038/s41598-022-23339-x

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Identification of a novel ALDH1A3-selective inhibitor by a chemical probe with unrelated bioactivity: An approach to affinity-based drug target discovery

Authors: Hiroshi Kamiyama, Masayuki Miyano, Daisuke Ito, Takayuki Kimura, Koji Hagiwara, Hiroyuki Kogai, Yosuke Kaburagi, Yoshihiko Kotake, Yasutaka Takase

Journal: Chem Biol Drug Des

PubMed ID: 36334047

Doi: 10.1111/cbdd.14176

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Base-editing-mediated dissection of a γ-globin cis-regulatory element for the therapeutic reactivation of fetal hemoglobin expression

Authors: Panagiotis Antoniou, Giulia Hardouin, Pierre Martinucci, Giacomo Frati, Tristan Felix, Anne Chalumeau, Letizia Fontana, Jeanne Martin, Cecile Masson, Megane Brusson, Giulia Maule, Marion Rosello, Carine Giovannangeli, Vincent Abramowski, Jean-Pierre de Villartay, Jean-Paul Concordet, Filippo Del Bene, Wassim El Nemer, Mario Amendola, Marina Cavazzana, Anna Cereseto, Oriana Romano, Annarita Miccio

Journal: Nat Commun

PubMed ID: 36333351

Doi: 10.1038/s41467-022-34493-1

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Association of neutrophil extracellular traps with fistula healing in patients with complex perianal fistulising Crohn's disease

Authors: Dongxing Cao, Keyu Qian, Ying Zhao, Jie Hong, Haoyan Chen, Xiaohui Wang, Nailin Yang, Cheng Zhang, Jingkai Cao, Keyu Jia, Guangyu Wu, Mingming Zhu, Jun Shen, Ye Zhang, Zhe Cui, Zheng Wang

Journal: J Crohns Colitis

PubMed ID: 36322703

Doi: 10.1093/ecco-jcc/jjac171

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Ectopic circSTK39 expression ameliorates hydrogen peroxide-induced human lens epithelial cell apoptosis and oxidative stress through the miR-125a-5p/ERCC6 pathway

Authors: Ming Guo, Fanfan Su, Yao Chen, Bo Su

Journal: Curr Eye Res

PubMed ID: 36322706

Doi: 10.1080/02713683.2022.2143529

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Developmentally regulated mitochondrial biogenesis and cell death competence in maize pollen

Authors: Karen C Chamusco, May N Milazzo, Kanchan S Bhan, Terry L Kamps, Prestina Smith, Modupeoluwa Durojaiye, Cristina D Moreira, Maria Gallo, Christine D Chase

Journal: BMC Plant Biol

PubMed ID: 36316635

Doi: 10.1186/s12870-022-03897-y

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A microbial transporter of the dietary antioxidant ergothioneine

Authors: Daniel G Dumitrescu, Elizabeth M Gordon, Yekaterina Kovalyova, Anna B Seminara, Brianna Duncan-Lowey, Emily R Forster, Wen Zhou, Carmen J Booth, Aimee Shen, Philip J Kranzusch, Stavroula K Hatzios

Journal: Cell

PubMed ID: 36347253

Doi: 10.1016/j.cell.2022.10.008

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Detection of concentration-dependent conformational changes in SARS-CoV-2 nucleoprotein by agarose native gel electrophoresis

Authors: Ryo Sato, Yui Tomioka, Chiaki Sakuma, Masataka Nakagawa, Yasunori Kurosawa, Kohei Shiba, Tsutomu Arakawa, Teruo Akuta

Journal: Anal Biochem

PubMed ID: 36427555

Doi: 10.1016/j.ab.2022.114995

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Selection of Brucella abortus mimetic epitopes for fast diagnostic purposes in cattle

Authors: Fabiana de Almeida Araújo Santos, Patrícia Tiemi Fujimura, Emília Rezende Vaz, Ana Cristina Honorato de Castro, Ana Graci Brito-Madurro, Vivian Alonso-Goulart, Luciana Machado Bastos, Belchiolina Beatriz Fonseca, Anna Monteiro Correia Lima, Luiz Ricardo Goulart

Journal: Vet Res Commun

PubMed ID: 36445603

Doi: 10.1007/s11259-022-10043-4

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Sequestration of a dual function DNA-binding protein by Vibrio cholerae CRP

Authors: Jacob A Gibson, Michael J Gebhardt, Renato E R S Santos, Simon L Dove, Paula I Watnick

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36343262

Doi: 10.1073/pnas.2210115119

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A glutamine-based single α-helix scaffold to target globular proteins

Authors: Albert Escobedo, Jonathan Piccirillo, Juan Aranda, Tammo Diercks, Borja Mateos, Carla Garcia-Cabau, Macarena Sánchez-Navarro, Busra Topal, Mateusz Biesaga, Lasse Staby, Birthe B Kragelund, Jesús García, Oscar Millet, Modesto Orozco, Murray Coles, Ramon Crehuet, Xavier Salvatella

Journal: Nat Commun

PubMed ID: 36400768

Doi: 10.1038/s41467-022-34793-6

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Bovine milk exosomes affected proliferation of macrophages under hypoxia

Authors: Svjetlana Matic, Vermont P Dia

Journal: Curr Res Food Sci

PubMed ID: 36387601

Doi: 10.1016/j.crfs.2022.11.002

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Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Authors: Liang Chen, Biyun Zhu, Gaomeng Ru, Haowei Meng, Yongchang Yan, Mengjia Hong, Dan Zhang, Changming Luan, Shun Zhang, Hao Wu, Hongyi Gao, Sijia Bai, Changqing Li, Ruoyi Ding, Niannian Xue, Zhixin Lei, Yuting Chen, Yuting Guan, Stefan Siwko, Yiyun Cheng, Gaojie Song, Liren Wang, Chengqi Yi, Mingyao Liu, Dali Li

Journal: Nat Biotechnol

PubMed ID: 36357717

Doi: 10.1038/s41587-022-01532-7

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Insights into glycosidic bond specificity of an engineered selective α-L-rhamnosidase N12-Rha via activity assays and molecular modelling

Authors: Bo Yu, Shiyu Luo, Yuhan Ding, Zijie Gong, Ting Nie

Journal: AMB Express

PubMed ID: 36370155

Doi: 10.1186/s13568-022-01489-5

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A Vaccine of SARS-CoV-2 S Protein RBD Induces Protective Immunity

Authors: Qiaoqiao Qu, Pengfei Hao, Wang Xu, Letian Li, Yuhang Jiang, Zhiqiang Xu, Jing Chen, Zihan Gao, Zhaoxia Pang, Ningyi Jin, Chang Li

Journal: Int J Mol Sci

PubMed ID: 36430190

Doi: 10.3390/ijms232213716

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Fitness Costs of pfhrp2 and pfhrp3 Deletions Underlying Diagnostic Evasion in Malaria Parasites

Authors: Shalini Nair, Xue Li, Standwell C Nkhoma, Tim Anderson

Journal: J Infect Dis

PubMed ID: 35709327

Doi: 10.1093/infdis/jiac240

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Proteomic Landscape and Deduced Functions of the Cardiac 14-3-3 Protein Interactome

Authors: Jia-Hua Qu, Kirill V Tarasov, Khalid Chakir, Yelena S Tarasova, Daniel R Riordon, Edward G Lakatta

Journal: Cells

PubMed ID: 36359893

Doi: 10.3390/cells11213496

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Evaluation of commercially available fully automated and ELISA-based assays for detecting anti-SARS-CoV-2 neutralizing antibodies

Authors: Hadeel T Zedan, Hadi M Yassine, Duaa W Al-Sadeq, Na Liu, Hamda Qotba, Eleonora Nicolai, Massimo Pieri, Sergio Bernardini, Laith J Abu-Raddad, Gheyath K Nasrallah

Journal: Sci Rep

PubMed ID: 36347859

Doi: 10.1038/s41598-022-21317-x

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Chaperoning activity of the cyclophilin family prevents tau aggregation

Authors: Shannon E Hill , Abigail R Esquivel , Santiago Rodriguez Ospina , Lauren M Rahal , Chad A Dickey , Laura J Blair

Journal: Protein Sci

PubMed ID: 36305768

Doi: 10.1002/pro.4448

Products & Services: PCR Cloning and Subcloning

Structure/function studies on the activation motif of two non-mammalian Mrap1 orthologs, and observations on the phylogeny of Mrap1, including a novel characterization of an Mrap1 from the chondrostean fish, Polyodon spathula.

Authors: Robert M. Dores , Greer McKinley, Audrey Meyers, Morgan Martin and Ciaran A. Shaughnessy

Journal: Biomolecules

Doi: 10.3390/biom12111681

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Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes

Authors: Zeyu Jin , Li Wan , Yuqi Zhang , Xuecheng Li , Yong Cao , Haobin Liu , Shengyao Fan , Du Cao , Zhengmao Wang , Xiaobo Li , Junmin Pan , Meng-Qiu Dong , Jianping Wu , Zhen Yan

Journal: Cell

PubMed ID: 36413996

Doi: 10.1016/j.cell.2022.10.030

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Rice FLOURY ENDOSPERM22, encoding a pentatricopeptide repeat protein, is involved in both mitochondrial RNA splicing and editing and is crucial for endosperm development

Authors: Hang Yang , Yunlong Wang , Yunlu Tian , Xuan Teng , Zehui Lv , Jie Lei , Erchao Duan , Hui Dong , Xue Yang , Yuanyan Zhang , Yinglun Sun , Xiaoli Chen , Xiuhao Bao , Rongbo Chen , Chuanwei Gu , Yipeng Zhang , Xiaokang Jiang , Wenyu Ma , Pengcheng Zhang , Yi Ji , Yu Zhang , Yihua Wang , Jianmin Wan

Journal: J Integr Plant Biol

PubMed ID: 36333887

Doi: 10.1111/jipb.13402

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Estrogen receptor β activation inhibits colitis by promoting NLRP6-mediated autophagy

Authors: Wentao Fan, Chenchen Ding, Shuhui Liu, Xiaona Gao, Xiaofei Shen, Marthe De Boevre, Zhangshan Gao, Mengcong Li, Shuo Zhang, Yufan Miao, Wenxian Guan, Guangliang Liu, Liping Yan, Sarah De Saeger, Suquan Song

Journal: Cell Rep

PubMed ID: 36223738

Doi: 10.1016/j.celrep.2022.111454

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Duration of antiretroviral therapy impacts the degree of residual SIV infection in the gut in long-term non-progressing Chinese rhesus macaques

Authors: Antonio Solis-Leal, Ann-Marie May, Mahesh Mohan, Jason P Dufour, Binhua Ling

Journal: J Med Virol

PubMed ID: 36181356

Doi: 10.1002/jmv.28185

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Recombinant acetylxylan esterase of Halalkalibacterium halodurans NAH-Egypt: molecular and biochemical study.

Authors: Amira M Embaby , Hoda E Mahmoud

Journal: AMB Express .

PubMed ID: 36289146

Doi: A10.1186/s13568-022-01476-w.

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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PDL1 bias-dependent way

Authors: Xiaolu Yu, Yiru Long , Binfan Chen , Yongliang Tong , Mengwen Shan , Xiaomin Jia , Chao Hu , Meng Liu , Ji Zhou , Feng Tang , Henglei Lu , Runqiu Chen , Pan Xu , Wei Huang , Jin Ren , Yakun Wan , Jianhua Sun , Jia Li , Guangyi Jin , Likun Gong

Journal: J Immunother Cancer .

PubMed ID: 36253000

Doi: 10.1136/jitc-2022-004590

Products & Services: Recombinant Proteins

Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease

Authors: Hangchen Hu, Qian Wang, Haixia Su, Qiang Shao, Wenfeng Zhao, Guofeng Chen, Minjun Li, Yechun Xu

Journal: Angew Chem Int Ed Engl

PubMed ID: 36308706

Doi: 10.1002/anie.202212378

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Molecular Effects of Iodine-Biofortified Lettuce in Human Gastrointestinal Cancer Cells

Authors: Olga Sularz, Aneta Koronowicz, Cayla Boycott, Sylwester Smoleń, Barbara Stefanska

Journal: Nutrients

PubMed ID: 36296971

Doi: 10.3390/nu14204287

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TMT-Based Quantitative Proteomic Analysis Reveals Downregulation of ITGAL and Syk by the Effects of Cycloastragenol in OVA-Induced Asthmatic Mice

Authors: Xueyi Zhu, Baojun Liu, Zhenhui Ruan, Mengmeng Chen, Congcong Li, Hanlin Shi, Xi Huang, Hang Yu, Yaolong Zhou, Hehua Zhu, Jing Sun, Ying Wei, Weifang Xu, Jingcheng Dong

Journal: Oxid Med Cell Longev

PubMed ID: 36329800

Doi: 10.1155/2022/6842530

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Photoprotective Effects of Cannabidiol against Ultraviolet-B-Induced DNA Damage and Autophagy in Human Keratinocyte Cells and Mouse Skin Tissue

Authors: Yanmei Li, Dan Hao, Danfeng Wei, Yue Xiao, Lian Liu, Xiaoxue Li, Lian Wang, Yu Gan, Wei Yan, Bowen Ke, Xian Jiang

Journal: Molecules

PubMed ID: 36235276

Doi: 10.3390/molecules27196740

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Molecular characterization of peptidoglycan recognition proteins from Mytilus coruscus

Authors: Zhi Liao, Zongxin Yang, Ying Wang, Jianyu He, Zhijiang He, Xiaolin Zhang, Isabella Buttino, Pengzhi Qi, Meihua Fan, Baoying Guo, Xiaojun Yan, Menglan He

Journal: Fish Shellfish Immunol

PubMed ID: 36272520

Doi: 10.1016/j.fsi.2022.10.018

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Regulation of Prolactin Release at the End Stage of Chicken Embryogenesis

Authors: Norio Kansaku, Shin Wakui, Tomohiro Sasanami, Takeshi Ohkubo

Journal: J Poult Sci

PubMed ID: 36382060

Doi: 10.2141/jpsa.0220023

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TBC1D18 is a Rab5-GAP that coordinates endosome maturation together with Mon1

Authors: Shu Hiragi, Takahide Matsui, Yuriko Sakamaki, Mitsunori Fukuda

Journal: J Cell Biol

PubMed ID: 36197338

Doi: 10.1083/jcb.202201114

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The diurnal emission of floral scent in Oncidium hybrid orchid is controlled by CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) through the direct regulation on terpene synthase

Authors: Chao-Wei Yeh, Hui-Qin Zhong, Yung-Feng Ho, Zhi-Hong Tian, Kai-Wun Yeh

Journal: BMC Plant Biol

PubMed ID: 36195835

Doi: 10.1186/s12870-022-03850-z

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Highly efficient hybridoma generation and screening strategy for anti-PD-1 monoclonal antibody development

Authors: Tanapati Phakham, Chatikorn Boonkrai, Tossapon Wongtangprasert, Thittaya Audomsun, Chadaporn Attakitbancha, Pijitra Saelao, Phijitra Muanwien, Sarintip Sooksai, Nattiya Hirankarn, Trairak Pisitkun

Journal: Sci Rep

PubMed ID: 36273231

Doi: 10.1038/s41598-022-20560-6

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Hydrogen-bonds mediate liquid-liquid phase separation of mussel derived adhesive peptides

Authors: Qi Guo, Guijin Zou, Xuliang Qian, Shujun Chen, Huajian Gao, Jing Yu

Journal: Nat Commun

PubMed ID: 36182948

Doi: 10.1038/s41467-022-33545-w

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An experimental test of the nicotinic hypothesis of COVID-19

Authors: Nicole E Godellas, Gisela D Cymes, Claudio Grosman

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36279466

Doi: 10.1073/pnas.2204242119

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Ultra-sensitive molecular detection of gene fusions from RNA using ASPYRE

Authors: Eleanor R Gray, Justyna M Mordaka, Efthimia R Christoforou, Kristine von Bargen, Nicola D Potts, Christina Xyrafaki, Ana-Luisa Silva, Magdalena Stolarek-Januszkiewicz, Katarzyna Anton, Paulina K Powalowska, Simonetta Andreazza, Alessandro Tomassini, Rebecca N Palmer, Aishling Cooke, Robert J Osborne, Barnaby W Balmforth

Journal: BMC Med Genomics

PubMed ID: 36224552

Doi: 10.1186/s12920-022-01363-0

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Long noncoding RNA-mediated activation of PROTOR1/PRR5-AKT signaling shunt downstream of PI3K in triple-negative breast cancer

Authors: Zhenbo Tu, Yi Hu, Devesh Raizada, Mahmoud A Bassal, Daniel G Tenen, Antoine E Karnoub

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36269860

Doi: 10.1073/pnas.2203180119

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AlphaFold version 20 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys-Cys) formation of functional significance for VIPR2

Authors: Kotaro Sakamoto, Satoshi Asano, Yukio Ago, Takatsugu Hirokawa

Journal: Biochem Biophys Res Commun

PubMed ID: 36332470

Doi: 10.1016/j.bbrc.2022.10.071

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Presence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies Among Vietnamese Healthcare Workers by Dosing Interval for ChAdOx1 nCoV-19 Vaccine

Authors: Dien M Vu, Diep T B Vu, Thuy T T Do, Allison E Olmsted, Bach H Dao, Truc T Thai, Chi L Nguyen, Nhung T T Le, Tuan A Le, Hien T T Bui, Thach N Pham, Matthew R Moore

Journal: Clin Infect Dis

PubMed ID: 35723271

Doi: 10.1093/cid/ciac493

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Systemic and Mucosal Humoral Immune Response Induced by Three Doses of the BNT162b2 SARS-CoV-2 mRNA Vaccines

Authors: Roberta Mancuso, Simone Agostini, Lorenzo Agostino Citterio, Debora Chiarini, Maria Antonia Santangelo, Mario Clerici

Journal: Vaccines (Basel)

PubMed ID: 36298514

Doi: 10.3390/vaccines10101649

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