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Structural decoding of reversible covalent linkage of odorants in human olfactory receptor OR6A2

Authors: Tian Wang, Yiran Wu, Ling Wang, Shanshan Li, Fei Zhao, Lijie Wu, Yue Liu, Jingzi Qin, Qiwen Tan, Junlin Liu, Liting Zeng, Yilin Chen, Shenyuan Gao, Wenqing Shui, Suwen Zhao, Tian Hua, Zhi-Jie Liu

Journal: Cell

PubMed ID: 41570822

Doi: 10.1016/j.cell.2025.12.017

Products & Services: Protein Electrophoresis and Western

SPARK-seq: A high-throughput platform for aptamer discovery and kinetic profiling

Authors: Guoyan Luo, Jia Song, Yongbo Fu, Yuanjie Jiang, Yuan Gao, Zhixing Zhong, Ling Li, Yong Wei, Hao-Ran Jia, Lu Guo, Ting Fu, Qin Wu, Weihong Tan

Journal: Science (New York, N.Y.)

PubMed ID: 41477891

Doi: 10.1126/science.adv6127

Products & Services: Protein Electrophoresis and Western

Phage-associated Cas12p nucleases require binding to bacterial thioredoxin for activation and cleavage of target DNA

Authors: Zhipeng Wang, Yujue Wang, Hui Gao, Jiani Dai, Na Tang, Yannan Wang, Quanjiang Ji

Journal: Nature Microbiology

PubMed ID: 41492065

Doi: 10.1038/s41564-025-02224-z

Products & Services: Protein Electrophoresis and Western

Antibody-induced internalization and degradation of PLA2R amplifies CD4+ T cell activation

Authors: Yuning Liu, Yinyin Li, Hui Zhou, Jieli Yu, Pei Deng, Weiwei Xu, Bingqian Pan, Lei Zhang, Hong Zhou, Jing Zhang, Xiaohan Liu, Min Shi, Xianchi Dong, Bei Tong, Enguang Bi, Nannan Guo, Yu Hu

Journal: Theranostics

PubMed ID: 41328348

Doi: 10.7150/thno.123035

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Schwann cell-derived extracellular vesicles inhibit osteoclastogenesis through the PTEN/AKT axis in peripheral nerve-bone crosstalk.

Authors: Huijian Yang, Biao Yu, Ruiyang Li, Yang Hong, Mingzhu Shen, Tianzhuo Shen, Xiuhui Wang, Han Liu, Guangchao Wang, Ke Xu, Yuhai Ma, Mengmeng Li, Jiacan Su

Journal: Journal of nanobiotechnology

PubMed ID: 41530784

Doi: 10.1186/s12951-026-04021-0

Products & Services: Protein Electrophoresis and Western

WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity

Authors: Duo Wang, Xianle Shi, Jiaying Xie, Lijie Zhao, Bin Wu, Qiman Dong, Yaoguang Huang, Jinlong Suo, Xinyu Wang, Beixuan He, Shukun Yan, Hongjuan Xue, Yuheng Shi, Yingbin Liu, Jianlong Wang, Yong Chen, Yanjing Li

Journal: Nature Communications

PubMed ID: 41565645

Doi: 10.1038/s41467-026-68623-w

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An integrated valved microfluidic platform for rapid and simultaneous nucleic acid detection

Authors: Zihan Wang, Fuwan Yang, Shuai Zeng, Rui Sun, Qifei Hu, Yichen Du

Journal: Lab on a chip

PubMed ID: 41439322

Doi: 10.1039/D5LC01096A

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Stress controls heterochromatin inheritance via histone H3 ubiquitylation

Authors: Bharat Bhatt, Yi Wei, Ashis Kumar Pradhan, Jothy Dhakshnamoorthy, Martin Zofall, Hua Xiao, Drisya Vijayakumari, Shweta Jain, Hernan Diego Folco, Hongyun Qi, David A Ball, Tatiana S Karpova, David Wheeler, Jiemin Wong, Shiv I S Grewal

Journal: Nature

PubMed ID: 41501458

Doi: 10.1038/s41586-025-09899-8

Products & Services: Protein and Antibody Isolation

Microbiota-induced T cell plasticity enables immune-mediated tumour control

Authors: Tariq A Najar, Yuan Hao, Yuhan Hao, Gabriela Romero-Meza, Alexandra Dolynuk, Emma Almo, Dan R Littman

Journal: Nature

PubMed ID: 41535459

Doi: 10.1038/s41586-025-09913-z

Products & Services: Codon Optimization

TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength

Authors: Martina Spiga, Alessia Potenza, Zulma Magnani, Stefano Beretta, Barbara Camisa, Laura Conte, Alessia Airaghi, Neda Mohammadi, Laura Perani, Claudio Doglioni, Maurilio Ponzoni, Francesca Sanvito, Chiara Balestrieri, Lucia Sergi Sergi, Oronza A Botrugno, Giulio Giovannoni, Giovanni Tonon, Danilo Abbati, Chiara Iozzi, Maximilian Reichert, Hana Algul, Arianna Pocaterra, Martina Fiumara, Samuele Ferrari, Alessia Ugolini, Alice Grometto, Giulia Di Lullo, Giovanni Sitia, Giulio Belfiori, Maria Pia Protti, Renato Ostuni, Anna Mondino, Michele Reni, Stefano Crippa, Massimo Falconi, Luigi Naldini, Eliana Ruggiero, Chiara Bonini

Journal: Nature Communications

PubMed ID: 41507193

Doi: 10.1038/s41467-025-67263-w

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Arboviruses manipulate rice’s volatile emissions, protecting insect vectors from natural enemies in the field

Authors: Qing Liu, Qian Wang, Qiong Li, Weiran Wang, Qi Li, Ziyuan Peng, Yuling Jiao, Feng Cui, Ian T Baldwin, Xiaoming Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 41499511

Doi: 10.1126/sciadv.aeb5215

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Cooperativity and communication between the active sites of the dimeric SARS-CoV-2 main protease

Authors: Sarah N Zvornicanin, Ala M Shaqra, Julia Flynn, Lauren E Intravaia, Heidi Carias Martinez, Weiping Jia, Devendra Kumar Gupta, Stephanie Moquin, Dustin Dovala, Daniel N Bolon, Brian A Kelch, Celia A Schiffer, Nese Kurt Yilmaz

Journal: SCIENCE ADVANCES

PubMed ID: 41544157

Doi: 10.1126/sciadv.aeb0769

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FLIPs: Genetically encoded molecular biosensors for functional imaging of cell signaling by linear dichroism microscopy

Authors: Paul Miclea, Vendula Nagy-Marková, Robin Van den Eynde, Wim Vandenberg, Alina Sakhi, Alexey Bondar, Jitka Myšková, Peter Dedecker, Josef Lazar

Journal: SCIENCE ADVANCES

PubMed ID: 41544164

Doi: 10.1126/sciadv.adz5662

Products & Services: Gene Synthesis

Optimally engineered HLA/peptide-specific CAR-T cells outperform TCR-T cells to eradicate solid tumors

Authors: Corinne E Decker, Jacqueline Idun, Katja Mohrs, Thomas Craig Meagher, Iryna Petriv, Jonathon Golas, Robert Salzler, Timothy Helms, Dharani Ajithdoss, Suhasini Avvaru, Jiaxi Wu, Tong Zhang, Eric Smith, Gavin Thurston, John C Lin, Jessica R Kirshner, David J DiLillo

Journal: SCIENCE ADVANCES

PubMed ID: 41564177

Doi: 10.1126/sciadv.adx9371

Products & Services: Gene Synthesis

Human cytomegalovirus regulates host DNA repair machinery for viral genome integrity

Authors: Pierce Longmire, Sebastian Zeltzer, Kristen Zarrella, Olivia Daigle, Marek Svoboda, Justin M Reitsma, Scott S Terhune, Carly Bobak, Giovanni Bosco, Felicia Goodrum

Journal: Nucleic Acids Research

PubMed ID: 41533576

Doi: 10.1093/nar/gkaf1445

Products & Services: Protein Electrophoresis and Western

Staufen dsRNA-binding domain as modules to design bifunctional antibodies for siRNA delivery

Authors: Yahui Liu, Yan Zheng, Ruolin Xu, Yanan Quan, Wanyi Tai

Journal: Nucleic Acids Research

PubMed ID: 41569158

Doi: 10.1093/nar/gkaf1539

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All-PEG-Like Block Copolymers Self-Assemble into Stealth Nanocarriers for Drug Delivery

Authors: Parul Sirohi, Brooke E Silverstein, Yulia Shmidov, Sonal Deshpande, Joy Tong, Yvonne Y Ma, Chinmay S Potnis, Soumen Saha, Xinghai Li, Max R Ney, Sarah Y Kim, Joshua J Milligan, Lixin Fan, Matthew L Becker, Daniel Reker, Ashutosh Chilkoti

Journal: Advanced Science

PubMed ID: 41549226

Doi: 10.1002/advs.202517048

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Dyslipidaemia-associated natural IgM improves oncolytic virus TILT-123 efficacy through antibody-dependent enhancement in solid tumours.

Authors: James Hugo Armstrong Clubb, Santeri Artturi Pakola, Sakari Joenväärä, Tatiana Viktorovna Kudling, Tiialotta Tohmola, Victor Arias, Elise Jirovec, Mirte van der Heijden, Dafne Carolina Alves Quixabeira, Annukka Pasanen, Lyna Haybout, Nea Ojala, Saru Basnet, Arianna Eleuteri, Julia Davila Ferrero, Stella Hirvenoja, Inge Marie Svane, Johanna Mäenpää, Katriina Jalkanen, Matthew Stephen Block, Tuomo Alanko, Tine Monberg, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Natasha Salmelin, Claudia Kistler, Riikka Havunen, Suvi Sorsa, João Manuel Dos Santos, Victor Cervera-Carrascon, Anna Kanerva, Otto Hemminki, Risto Renkonen, Akseli Hemminki

Journal: Molecular Therapy

PubMed ID: 41566775

Doi: 10.1016/j.ymthe.2026.01.019

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Genetic engineering of systemically injectable oncolytic viruses for pyroptosis-accelerated cancer virotherapy

Authors: Xiaohong Chen, Minqi Yang, Yuxuan Chen, Yao Zhang, Shuang Wang, Jiaqi Meng, Zunqiao Zhu, Wen Li, Wei Wei, Yuan Ping, Tingbo Liang

Journal: Nature cancer

PubMed ID: 41545714

Doi: 10.1038/s43018-025-01078-y

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Protection against lethal canine distemper virus infection by a dual epitope-targeting synthetic antibody

Authors: Melanie Scherer, Nadia Djabeur, Oliver Siering, Jean-Marc Jeckelmann, Marianne Wyss, Marina Cresci, Morgane Di Palma Subran, Rainer Riedl, Patrick Chames, Christian K Pfaller, Bevan Sawatsky, Dimitrios Fotiadis, Philippe Plattet

Journal: Nature Communications

PubMed ID: 41501035

Doi: 10.1038/s41467-025-67600-z

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ERECTA genes and their ligands regulate shoot and inflorescence architecture in maize

Authors: Xiao Liu, Jinbiao Wang, Jipeng Li, Lu Kang, Mengyan Wang, Zhaoyu Huang, Jarrett Man, Xuxu Huang, Zhiming Zhang, Fang Yang, Madelaine Bartlett, Liuji Wu, Zhaobin Dong, David Jackson, Fang Xu

Journal: Nature Communications

PubMed ID: 41526346

Doi: 10.1038/s41467-025-67634-3

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Mechanism of trans-envelope bacterial polysaccharide secretion in Class-3 outer-membrane polysaccharide export (OPX) protein systems

Authors: Abdelkader Mellouk, Kenny Ngo, Ahmad A Kezzo, Cyrielle Martini, Tanos C C França, Steven R Laplante, Salim T Islam, Charles Calmettes

Journal: Nature Communications

PubMed ID: 41545361

Doi: 10.1038/s41467-025-67321-3

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Metal ions govern coronavirus endoribonuclease activity

Authors: Xionglue Wang, Jing Li, Zhichao Liu, Longfei Wang, Bin Zhu

Journal: Nucleic Acids Research

PubMed ID: 41533565

Doi: 10.1093/nar/gkaf1508

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Substituent-Based Modulation of Self-Assembly and Immunogenicity of Amphipathic Peptides

Authors: Anirban Das, Ushasi Pramanik, Elise M Brown, Chih-Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E Jackrel, Mark A White, Jai S Rudra

Journal: Advanced Science

PubMed ID: 41560329

Doi: 10.1002/advs.202518567

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Pan2-Pan3 Complex-Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus

Authors: Ziwei Lv, Junting Feng, Shenxian Zhou, Zhiguang Qu, Jun Peng, Xiao-Lin Chen, Deng Chen

Journal: Advanced Science

PubMed ID: 41556236

Doi: 10.1002/advs.202518269

Targeting WTAP/ROR1/WNT5A-Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Authors: Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai

Journal: Advanced Science

PubMed ID: 41562250

Doi: 10.1002/advs.202520661

Products & Services: Protein Electrophoresis and Western

Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation

Authors: Jun Nagai, Madeline M Hastings, Airi Nishida, Sreyashi Majumdar, Kendall Zaleski, Sofia A Marshall, Junrui Lin, Mira A S Saliman, Yumi Tani, Yamato Murakami, Chunli Feng, Alexander Perniss, Caitlin Wong, Lora G Bankova, Asuka Inoue, Nora A Barrett, Joshua A Boyce

Journal: Cell Reports

PubMed ID: 41422505

Doi: 10.1016/j.celrep.2025.116758

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Cooked meat-derived extracellular vesicles ssc-miR-1 induces metabolic disorders in the mice liver via PI3k/AKT pathway

Authors: Linyuan Shen, Jianfeng Ma, Shuang Liang, Yiting Yang, Tianci Liao, Yuhang Lei, Lei Chen, Yan Wang, Ye Zhao, Lili Niu, Mailin Gan, Li Zhu

Journal: NPJ science of food

PubMed ID: 41577711

Doi: 10.1038/s41538-026-00709-7

Products & Services: Protein Electrophoresis and Western

DUSP22 dephosphorylates LGALS1 to enhance T cell-driven antitumor immunity

Authors: Lijian Wang, Yutong Guo, Yujie Dai, Wangsheng Sun, Xiaoying Huang, Haipeng Lei, Aiping Zhang, Shuwen Chen, Yiting Li, Jiani Pan, Yangjian Hong, Lingchuan Ma, Yangyang Feng, Fangyuan Shao, Jianming Zeng, Peng Luo, Junqi Li, Weiting Chen, Na Zhou, Yang Li, Heng Sun, Xiaoling Xu, Chu-Xia Deng, Kai Miao

Journal: Journal for ImmunoTherapy of Cancer

PubMed ID: 41611244

Doi: 10.1136/jitc-2025-013142

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CATSPERε extracellular domains are essential for sperm calcium channel assembly and activity modulation

Authors: Jae Yeon Hwang, Huafeng Wang, Jong-Nam Oh, Jingon Kim, Sarah F Finnegan, Niels E Skakkebaek, Jean-Ju Chung

Journal: Science advances

PubMed ID: 41604475

Doi: 10.1126/sciadv.adw341

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IgG-Bridging–Seeded Synergistic Aggregation of SARS-CoV-2 Spikes Underlies Potent Neutralization by a Low-Affinity Antibody

Authors: Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li-Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

PubMed ID: 41355083

Doi: 10.1002/advs.202517192. Online ahead of print.

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Thermodynamic Profiling Reveals DNA Polymerase Template Binding, Substrate Incorporation, and Exonuclease Function

Authors: Yaping Sun, Wu Lin, Kang Fu, Jie Gao, Xianhui Zhao, Yun He, Hui Tian

Journal: International Journal of Molecular Sciences

Doi: doi.org/10.3390/ijms262411909

Products & Services: Gene Synthesis Plasmid DNA Preparation Protein Electrophoresis and Western CRISPR KI Templates

Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity

Authors: Christopher R Horne, Tingting Wang, Samuel N Young, Toby A Dite, Hunter G Nyvall, Sushant Suresh, Katherine A Davies, Abner Gonzalez Castro, Vineet Vaibhav, Lucy J Mather, Laura F Dagley, Matthew J Belousoff, Gerard Manning, Anthony R Means, John E Burke, Janni Petersen, John W Scott, James M Murphy

Journal: The Biochemical journal

PubMed ID: 41003242

Doi: doi.org/10.1042/BCJ20253431

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Iterative Epitope Expansion Enables Structure-Guided de novo Design of IgE-Binding Miniproteins Targeting the FcεRI Interface

Authors: Ido Calman, Hamed Shaykhalishahi, Puwanat Sangkhapreecha, Sharrol Bachas

Journal: biorxiv

Doi: 10.64898/2025.12.27.696647

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A Multimodal Ensemble Framework for Optimal Mutant Prediction and Computational Enzyme Engineering

Authors: Ding Luo, Huining Ji, Baodong Hu, Jinxing Cai, Kaiqi Wen, Xiaoyang Qu, Mingfeng Cao, Xinrui Zhao, Binju Wang

Journal: ANGEWANDTE CHEMIE

PubMed ID: 41410226

Doi: 10.1002/anie.202521396

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Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Authors: Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong-Hui Zheng

Journal: Advanced Science

PubMed ID: 41324484

Doi: 10.1002/advs.202519256

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U-Shaped Response of Flowering Time to Low and High Nitrogen via a Transcription Feedback Loop in Rice

Authors: Shunan Zhang, Guanzhong Shou, Xianping Li, Xuemin Song, Xuesong Li, Junjie Guo, Jiaqiang Lu, Yi Jin, Hongye Qu, Ming Yan, Wona Ding, Ying Liu, Guohua Xu

Journal: Advanced Science

PubMed ID: 41354635

Doi: 10.1002/advs.202508498

Tuning CAR-T cells by targeting cancer-associated glycan in pancreatic cancer

Authors: Sangwoo Park, Cassidy E Ho, Eli P Darnell, Alexandra N Wolff, Hana Takei, Filippo Birocchi, Amanda A Bouffard, Diego Salas-Benito, Giulia Escobar, Mark B Leick, Adele Mucci, Trisha R Berger, Marcela V Maus

Journal: Nature Communications

PubMed ID: 41372740

Doi: 10.1038/s41467-025-66102-2

A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription

Authors: Anna Minello, Jesus Gomez-Escudero, Sreerama Chaitanya Sridhara, Charlotte Martin, Elodie Girard, Juan C Cañas, Yasin Memari, Maria Rose Bustos, Antonio Galarreta, Virginie Boucherit, Evgeny Imyanitov, Sigridur Klara Bodvarsdottir, Sylvain Baulande, Anne Vincent-Salomon, Nicolas Servant, Matthias Altmeyer, Stefan Sigurdsson, Dominique Stoppa-Lyonnet, Serena Nik-Zainal, Aura Carreira

Journal: Nature Communications

PubMed ID: 41372141

Doi: 10.1038/s41467-025-67209-2

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HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA

Authors: Alfred M Lentzsch, Ziyi Fan, Inayat U Irshad, Edward P O'Brien, Ajeet K Sharma, Rachel Green, Shu-Ou Shan

Journal: Molecular Cell

PubMed ID: 41380682

Doi: 10.1016/j.molcel.2025.11.017

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Collision-induced ribosome degradation driven by ribosome competition and translational perturbations

Authors: Sihan Li, Okuto Shounai, Misaki Kato, Ken Ikeuchi, Toshifumi Inada

Journal: Nature Communications

PubMed ID: 41387539

Doi: 10.1038/s41467-025-66026-x

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Gut Microbe-Driven Resistance Mechanisms in Propylea Japonica: Insights from Horizontal Gene Transfer and Oxidative Phosphorylation

Authors: Ningbo HuangFu, Xiangzhen Zhu, Zhijuan Tang, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Jinjie Cui, Zhaojiang Guo, Junyu Luo, Xueke Gao

Journal: Advanced Science

PubMed ID: 41386783

Doi: 10.1002/advs.202520326

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Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery

Authors: Ming-You Shie, Shi-Wei Huang, Yeh Chen, Mei-Chih Chen, Chih-Ming Pan, Cheng-Yu Chen, Yen-Hong Lin, Min-Hua Yu, Kai-Wen Kan, Shao-Chih Chiu, Hui-Chun Ho, Yi-Wen Chen, Der-Yang Cho

Journal: Nature Communications

PubMed ID: 41390497

Doi: 10.1038/s41467-025-66451-y

The Human T-cell Leukemia Virus capsid protein is a potential drug target

Authors: Ruijie Yu, Prabhjeet Phalora, Nan Li, Till Böcking, David Anthony Jacques

Journal: Nature Communications

PubMed ID: 41345105

Doi: 10.1038/s41467-025-65899-2

Structure-Based Development of Ultra-Broad-Spectrum 3C-Like Protease Inhibitors

Authors: Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu

Journal: Advanced Science

PubMed ID: 41388583

Doi: 10.1002/advs.202512342

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Protein-nucleic acid language model-assisted design of precise and compact adenine base editor

Authors: Jingxuan Ren, Jiawei Yao, Qiuyu Cao, Yinuo Li, Yang Li, Ziyi Zhang, Xiyu Ge, Shengfang Wang, Yang Zhang, Xiaogang Wang, Xiaohui Zhang

Journal: Nature Communications

PubMed ID: 41390734

Doi: 10.1038/s41467-025-65311-z

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Organ-specific delivery of an mRNA-encoded bispecific T cell engager targeting glypican-3 in hepatocellular carcinoma

Authors: Yan Huang, Shaoli Liu, Xiaoju Zhang, Bingxu Zhang, Feng Shi, Jia Zhang, Shuaibo Shao, Hongya Han, Xiaoyun Ma, Jing Xie, Jianqi Zhang, Hongxiaoying Yu, Yongchao Zhao, Jiazheng Jin, Dong Xu, Liang Liu, Jianing Wang, Yu Tan, Kelu Xu, Lushuai Jin, Quanjun Du, Yifeng Geng, Andong Liu, Wei Xu

Journal: Nature Communications

PubMed ID: 41397962

Doi: 10.1038/s41467-025-66087-y

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Molecular insights into ligand recognition and signaling of OXGR1

Authors: Aijun Liu, Yezhou Liu, Yuanzhengyang Long, Richard D Ye

Journal: Nature Communications

PubMed ID: 41413034

Doi: 10.1038/s41467-025-67101-z

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Cynarin as a potent anti‑osteolytic agent: Targeting MAPK and Nrf2‑Keap1 pathways for osteoclast inhibition and bone protection

Authors: Rui Chao, Yexin Wang, Zhan Liu, Tianhao Wan, Yi Mao, Xinru Xie, Lei Sun, Weifeng Xu, Xuzhuo Chen, Shanyong Zhang

Journal: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PubMed ID: PMC12488209

Doi: 10.3892/ijmm.2025.5647

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Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender

Authors: Yan Huang, Biao Hu, Ya Liu, Ling-Qi Xie, Yu Dai, Yu-Ze An, Xin-Yi Peng, Ya-Lun Cheng, Yi-Fan Guo, Wei-Hong Kuang, Yao Xiao, Xin Chen, Yong-Jun Zheng, Gen-Qing Xie, Jian-Ping Wang, Hui Peng, Xiang-Hang Luo

Journal: Cell metabolism

PubMed ID: 41344322

Doi: doi.org/10.1016/j.cmet.2025.11.002

Products & Services: Nucleic Acid Purification