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The OsIAA3-OsARF16-OsBUL1 auxin signaling module regulates grain size in rice

Authors: Fengjun Xian, Shuya Liu, Jishuai Huang, Bin Xie, Lin Zhu, Qiannan Zhang, Chen Lv, Yimeng Xu, Xinrong Zhang, Jun Hu

Journal: Plant Physiol

PubMed ID: 40156155

Doi: 10.1093/plphys/kiaf122

Products & Services: Custom DNA/RNA Oligos

ER nests are specialized ER subdomains in Arabidopsis where peroxisomes and lipid droplets form

Authors: Zachary J Wright , Nathan E Tharp , Bonnie Bartel

Journal: Developmental cell

Doi: 10.1016/j.devcel.2025.03.005

Products & Services: Gene Synthesis Proteins, Expression, Isolation and Analysis

Active- and Allosteric-Site Cyclic Peptide Inhibitors of Secreted M. tuberculosis Chorismate Mutase

Authors: Renier H P van Neer, Patricia K Dranchak, Mahesh Aitha, Lijun Liu, Emma K Carlson, Isabella E Jacobsen, Kevin Battaile, Yuhong Fang, Dingyin Tao, Ganesha Rai, Janak Padia, Scott Lovell, Hiroaki Suga, James Inglese

Journal: ACS Infectious Diseases

PubMed ID: 39903128

Doi: 10.1021/acsinfecdis.4c00798

Products & Services: Peptide Synthesis Plasmid DNA Preparation

Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus

Authors: Yansi Xian, Bin Liu, Tao Shen, Lin Yang, Rui Peng, Hongdou Shen, Xueying An, Yutian Wang, Yu Ben, Qing Jiang, Baosheng Guo

Journal: Bone Res

PubMed ID: 40025004

Doi: 10.1038/s41413-024-00399-5

Products & Services: Proteins, Expression, Isolation and Analysis

Structure-Guided Development of Chemically Tailored Peptide Binders of RNF43/ZNRF3 to Enable Versatile Design of Membrane Protein-Targeting PROTACs

Authors: Jibin Cui , Qingyun Zheng , Yicheng Weng , Xiaoguo Zhai , Zhen Su , Yunxiang Du , Xiaoxiong Wei , Yuanyuan Yu , Qian Qu , Man Pan

Journal: ANALYTICAL CHEMISTRY

PubMed ID: 40000409

Doi: doi.org/10.1002/anie.202501488

Products & Services: Codon Optimization Gene Synthesis

Rational Design Assisted by Evolutionary Engineering Allows (De)Construction and Optimization of Complex Phenotypes in Pseudomonas putida KT2440

Authors: Blas Blázquez, Juan Nogales

Journal: Microbial Biotechnology

PubMed ID: 40126873

Doi: 10.1111/1751-7915.70132

Products & Services: Gene Synthesis

Deciphering molecular specificity in MCL-1/BAK interaction and its implications for designing potent MCL-1 inhibitors

Authors: Hudie Wei, Haolan Wang, Shuang Xiang, Jiaqi Wang, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Xiaoyun Lu, Yongheng Chen

Journal: Cell Death Differ

PubMed ID: 39901037

Doi: 10.1038/s41418-025-01454-2

Products & Services: Peptide Synthesis

Expanding Cas12a Activity Control with an RNA G-Quadruplex at the 5′ end of CRISPR RNA

Authors: Wenjuan Huang, Jiaqi Wang, Cheng Wang, Yuanfang Liu, Wentao Li, Qiaozhen Chen, Junqiu Zhai, Zhenyang Xiang, Chaoxing Liu

Journal: Advanced Science

PubMed ID: 39721016

Doi: 10.1002/advs.202411305

Products & Services: GenCrispr Cas9 Genome Editing

Self-assembly GSH response based Buforin IIb-Olaparib nanocombination synergistically promotes DNA damage for prostate cancer immunotherapy

Authors: Maosong Hu , Yuyu Zhu , Xinyi Tang , Jing Xu , Hanbin Ma , Zhihan Chen , Duo Chen , Wenyuan Wu , Xialin Chen , Rongrong He , Jing Zhou , Jinao Duan , Weiguo Chen , Hongyue Ma

Journal: Chemical Engineering Journal

Doi: 10.1016/j.cej.2025.160862

Products & Services: Peptide Synthesis

EXPERT expands prime editing efficiency and range of large fragment edits

Authors: Youcai Xiong , Yinyu Su , Ruigao He , Xiaosong Han , Sheng Li , Minghuan Liu , Xiaoning Xi , Zijia Liu , Heng Wang , Shengsong Xie , Xuewen Xu , Kui Li , Jifeng Zhang , Jie Xu , Xinyun Li , Shuhong Zhao , Jinxue Ruan

Journal: Nat Commun

PubMed ID: 39939583

Doi: 10.1038/s41467-025-56734-9

Products & Services: Gene Synthesis

Oral delivery of therapeutic proteins by engineered bacterial type zero secretion system

Authors: Xu Gong , Shan Liu , Bozhang Xia , Yichen Wan , Shuyi Zhang , Baoyan Zhang , Zehao Wang , Junge Chen , Fei Xiao , Xing-Jie Liang , Yun Yang

Journal: Nat Commun

PubMed ID: 39984501

Doi: 10.1038/s41467-025-57153-6

Products & Services: Gene Synthesis

Enhancing mRNA translation efficiency by introducing sequence optimized AU-rich elements in 3′ UTR via HuR anchorage

Authors: Xinghuan Ma , Sujia Liu , Bangda Fan , Danni Jin , Lei Miao , Lin Liu , Shubo Du , Jiaqi Lin

Journal: Mol Ther Nucleic Acids

PubMed ID: 40125272

Doi: doi.org/10.1016/j.omtn.2025.102485

Products & Services: Gene Synthesis

Controllable intein splicing and N-terminal cleavage at mesophilic temperatures

Authors: Taylor A McNeal, Joel Weinberger, Geraldy L S Liman, Tia M Ariagno, David W Wood, Thomas J Santangelo, Christopher W Lennon

Journal: Front Bioeng Biotechnol

PubMed ID: 39991137

Doi: 10.3389/fbioe.2025.1543573

Products & Services: Gene Synthesis Mutagenesis Services

PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins

Authors: Christopher R Horne, Toby A Dite, Samuel N Young, Lucy J Mather, Laura F Dagley, Jared L Johnson, Tomer M Yaron-Barir, Emily M Huntsman, Leonard A Daly, Dominic P Byrne, Antonia L Cadell, Boaz H Ng, Jumana Yousef, Dylan H Multari, Lianju Shen, Luke M McAloon, Gerard Manning, Mark A Febbraio, Anthony R Means, Lewis C Cantley, Maria C Tanzer, David R Croucher, Claire E Eyers, Patrick A Eyers, John W Scott, James M Murphy

Journal: Proc Natl Acad Sci U S A

PubMed ID: 39964718

Doi: 10.1073/pnas.2420961122

Products & Services: Peptide Synthesis

Double antibody sandwich ELISA based on rabbit monoclonal antibody targeting gD protein for the detection of bovine herpesvirus 1

Authors: Qiang Liu, Xiaoxia Niu, Lingling Jiang, Gang Zhang, Pu Wang, Sinong Zhang, Weifeng Gao, Huichen Guo, Yujiong Wang, Yong Li

Journal: Int J Biol Macromol

PubMed ID: 39929469

Doi: 10.1016/j.ijbiomac.2025.140671

Products & Services: Gene Synthesis

DNA tetrahedron nanomedicine for enhanced antitumor and antimetastatic effect through the amplification of mitochondrial oxidative stress

Authors: Zixuan Chen , Zhaoyan Tian , Yafeng Wu , Songqin Liu

Journal: Acta Biomater

PubMed ID: 39922515

Doi: 10.1016/j.actbio.2025.02.011

Products & Services: Proteins, Expression, Isolation and Analysis

Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK

Authors: Chang Peng, Haowen Jiang, Liya Jing, Wenhua Yang, Xiaotong Guan, Hanlin Wang, Sike Yu, Yutang Cao, Min Wang, Huan Ma, Zan Lv, Hongyu Gu, Chunmei Xia, Xiaozhen Guo, Bin Sun, Aili Wang, Cen Xie, Wenbiao Wu, Luyiyi Lu, Jiayi Song, Saifei Lei, Rui Wu, Yi Zang, Erjiang Tang, Jia Li

Journal: Nat Commun

PubMed ID: 39966410

Doi: 10.1038/s41467-025-57044-w

Products & Services: Peptide Synthesis

Distinct immunogenicity outcomes of DNA vaccines encoding malaria transmission-blocking vaccine target antigens Pfs230D1M and Pvs230D1

Authors: Yi Cao , Maisa da Silva Araujo , Cynthia G Lorang , Najara Akira Costa Dos Santos , Abhai Tripathi , Joseph Vinetz , Nirbhay Kumar

Journal: Vaccine

PubMed ID: 39787798

Doi: 10.1016/j.vaccine.2024.126696

Products & Services: Gene Synthesis Plasmid DNA Preparation

Identifying Exifone as a Dual-Target Agent Targeting Both SARS-CoV-2 3CL Protease and the ACE2/S-RBD Interaction Among Clinical Polyphenolic Compounds

Authors: Jiani Lu、Yan Tang、Hongtao Li、Xixiang Chen、Pengcheng Qin、Jianrong Xu、Weihua Li 和 Lili Chen

Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Doi: doi.org/10.3390/ijms26052243

Products & Services: Plasmid DNA Preparation

Polyamine-Depleting Hydrogen-Bond Organic Frameworks Unleash Dendritic Cell and T Cell Vigor for Targeted CRISPR/Cas-Assisted Cancer Immunotherapy

Authors: Yongchun Pan, Fei Zeng, Xiaowei Luan, Guanzhong He, Shurong Qin, Qianglan Lu, Bangshun He, Xin Han, Yujun Song

Journal: Adv Mater

PubMed ID: 39972681

Doi: 10.1002/adma.202411886

Products & Services: Recombinant Proteins

Establishment of an indirect ELISA method for detecting bovine coronavirus antibodies based on N protein

Authors: Qiang Liu , Xiaoxia Niu , Lingling Jiang , Gang Zhang , Pu Wang , Sinong Zhang , Weifeng Gao , Huichen Guo, Yujiong Wang and Yong Li

Journal: Frontiers in Veterinary Science

Doi: 10.3389/fvets.2025.1530870

Products & Services: Plasmid DNA Preparation

In vitro reconstitution of meiotic DNA double-strand-break formation

Authors: Xinzhe Tang , Zetao Hu , Jian Ding , Meixia Wu , Pin Guan , Yawei Song , Yue Yin , Wei Wu , Jinbiao Ma , Ying Huang , Ming-Han Tong

Journal: Nature

PubMed ID: 39972125

Doi: doi.org/10.1038/s41586-024-08551-1

Products & Services: Custom DNA/RNA Oligos

A truncated pre-F protein mRNA vaccine elicits an enhanced immune response and protection against respiratory syncytial virus

Authors: Min Lin, Yifan Yin, Xiaomeng Zhao, Chen Wang, Xueqing Zhu, Letao Zhan, Li Chen, Siling Wang, Xue Lin, Jun Zhang, Ningshao Xia, Zizheng Zheng

Journal: Nat Commun

PubMed ID: 39910047

Doi: 10.1038/s41467-025-56302-1

Products & Services: Proteins, Expression, Isolation and Analysis

Perturbing Organelle-Level K+/Ca2+ Homeostasis by Nanotherapeutics for Enhancing Ion-Mediated Cancer Immunotherapy

Authors: Jun-Long Liang , Qian-Xiao Huang , Qi-Wen Chen , Xiao-Kang Jin , Zi-Yi Han 1, Ping Ji , Si-Xue Cheng , Wei-Hai Chen , Xian-Zheng Zhang

Journal: Adv Mater

PubMed ID: 39955648

Doi: 10.1002/adma.202416574

Products & Services: Recombinant Proteins

Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival

Authors: Wen Wei, Xueqin Gao, Jiawei Qian, Lei Li, Chen Zhao, Li Xu, Yanfei Zhu, Zhenzhen Liu, Nengrong Liu, Xueqing Wang, Zhicong Jin, Bowen Liu, Lan Xu, Jin Dong, Suping Zhang, Jiarong Wang, Yumu Zhang, Yao Yu, Zhanjun Yan, Yanjun Yang, Jie Lu, Yixuan Fang, Na Yuan, Jianrong Wang

Journal: Journal of Clinical Investigation

PubMed ID: 39589832

Doi: 10.1172/JCI177375.

Products & Services: Proteins, Expression, Isolation and Analysis

A Granzyme B‑Cleavable T Cell-Targeted Bispecific Cell Vesicle Connector for Reversing New-Onset Type 1 Diabetes

Authors: Yanfang Wang, Yanping Sun, Xiuwen Zhang, Shenqiang Wang, Xuehui Huang, Kairui Xu, Yun Liu, Yingqi Huang, Jianchang Xu, Xinwei Wei, Hao Cheng, Liqiang Pan, Jinqiang Wang, Zhen Gu

Journal: Journal of the American Chemical Society

PubMed ID: 39869523

Doi: 10.1021/jacs.4c13644

Products & Services: Gene Synthesis

Elastin-like polypeptide: A novel titanification biomacromolecule for green and ultrafast synthesis of biotitania nanoparticles via biomimetic mineralization

Authors: Lixi Cai, Jinlin Zheng, Lixing Liu, Guangya Zhang, Yuanqing Lin

Journal: Int J Biol Macromol

PubMed ID: 40015400

Doi: 10.1016/j.ijbiomac.2025.141449

Products & Services: Gene Synthesis

Macrophage-specific in vivo RNA editing promotes phagocytosis and antitumor immunity in mice

Authors: Yuxuan Chen , Xiaohong Chen , Yao Zhang , Meng Wang , Minqi Yang , Ruiji Wang , Xiaojie Yan , Shiyi Shao , Huhu Xin , Qida Hu , Wei Wei , Yuan Ping

Journal: Sci Transl Med

PubMed ID: 39813319

Doi: 10.1126/scitranslmed.adl5800

Products & Services: Recombinant Proteins

Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues

Authors: Fenghou Yuan, Huitang Qi, Binghui Song, Yuntian Cui, Junsheng Zhang, Huan Liu, Bo Liu, Hai Lei, Tian Liu

Journal: nature COMMUNICATION

PubMed ID: 39870637

Doi: doi.org/10.1038/s41467-025-56422-8

Products & Services: Gene Synthesis

Phosphorylation of PIP2;7 by CPK28 or Phytophthora kinase effectors dampens pattern-triggered immunity in Arabidopsis

Authors: Hai Zhu, Yazhou Bao, Hao Peng, Xianglan Li, Weiye Pan, Yufeng Yang, Zifei Kuang, Peiyun Ji, Jinding Liu, Danyu Shen, Gan Ai, Daolong Dou

Journal: Plant Communications

PubMed ID: 39277790

Doi: 10.1016/j.xplc.2024.101135

Products & Services: Catalog Peptides

Delivery of FGF18 using mRNA-LNP protects the cartilage against degeneration via alleviating chondrocyte senescence

Authors: Keyu Kong, Baixing Li, Yongyun Chang, Chen Zhao, Hua Qiao, Minghao Jin, Xinru Wu, Wenxuan Fan, Liao Wang, Yansong Qi, Yongsheng Xu, Zanjing Zhai, Peixiang Ma, Huiwu Li

Journal: Journal of nanobiotechnology

PubMed ID: 39844298

Doi: 10.1186/s12951-025-03103-9

Products & Services: Recombinant Proteins

The Silkworm (Bombyx mori) Neuropeptide Orcokinin's Efficiency in Whitening and Skincare

Authors: Pingyang Wang, Xiao Xiao, Ya Yang, Guiqiu Liang, Shengtao Lu, Liang Tang, Hongyan Huang, Ji He, Xiaoling Tong

Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PubMed ID: 39940730

Doi: 10.3390/ijms26030961.

Products & Services: Peptide Synthesis

Structural insights into RNA cleavage by PIWI Argonaute

Authors: Zhiqing Li , Qikui Xu , Jing Zhong , Yan Zhang , Tianxiang Zhang , Xiaoze Ying , Xiaoli Lu , Xiaoyi Li , Li Wan , Junchao Xue , Jing Huang , Ying Zhen , Zhao Zhang， Jianping Wu , En-Zhi Shen

Journal: Nature

PubMed ID: 39814893

Doi: 10.1038/s41586-024-08438-1

Products & Services: Plasmid DNA Preparation

Access to Axially Chiral Biaryl Benzylamines via Ancestral Enzyme- Enabled Reductive Amination Desymmetrization

Authors: Wen-Qing, ZhengXin-Xin, ZhuZheng, ZhuTairan, YangLifen, ZhengRui, PanShenlin, WangLixin, ZhangQi, ChenJian-He, XuYongtao Xie, Yongtao Xie

Journal: ACS catalysis

Doi: 10.1021/acscatal.4c06881

Products & Services: Plasmid DNA Preparation

TMT-Based Quantitative Proteomic Profiling of Human Esophageal Cancer Cells Reveals the Potential Mechanism and Potential Therapeutic Targets Associated With Radioresistance

Authors: Aidi Gao , Chao He , Hengrui Chen , Qianlin Liu , Yin Chen , Jianying Sun , Chuanfeng Wu , Ya Pan , Sonia Rocha , Mu Wang , Jundong Zhou

Journal: Proteomics Clin Appl

PubMed ID: 39375892

Doi: 10.1002/prca.202400010

Products & Services: Proteins, Expression, Isolation and Analysis

Ligand-Responsive Artificial Protein–Protein Communication for Field-Deployable Cell-Free Biosensing

Authors: Ke Wang , Siqian Liu , Shuqi Zhou , Aori Qileng , Dingyi Wang , Yingju Liu , Chunlai Chen , Chunyang Lei , Zhou Nie

Journal: Angew Chem Int Ed Engl

PubMed ID: 39558180

Doi: 10.1002/anie.202416671

Products & Services: PCR Cloning and Subcloning

A high-definition spatiotemporal transcriptomic atlas of mammalian kidney development

Authors: Shan Jiang, Hao Yu, Ting Zhao, Yao Lu, Xuesong Li, Lei Gao, Jie Mi, Wenzhe Xia, Lanjun Geng, Panpan Li, Mingyue Chen, Mengyao Kang, Jiang Liu, Yuwen Ke

Journal: The innovation

Doi: doi.org/10.1016/j.xinn.2024.100767

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson’s disease model mice

Authors: Wei Song, Zi-Ming Zhou, Le-le Zhang, Hai-Feng Shu, Jin-Ru Xia, Xia Qin, Rong Hua, Yong-Mei Zhang

Journal: Cell Death Dis

PubMed ID: 39809747

Doi: 10.1038/s41419-025-07333-5

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Mouse totipotent blastomere-like cells model embryogenesis from zygotic genome activation to post implantation

Authors: Bing Peng , Qingyi Wang , Feixiang Zhang , Hui Shen , Peng Du

Journal: Cell Stem Cell

PubMed ID: 39826539

Doi: doi.org/10.1016/j.stem.2024.12.006

Products & Services: Proteins, Expression, Isolation and Analysis

Systematic functional characterization of non-coding regulatory SNPs associated with central obesity

Authors: Shan-Shan Dong, Yuan-Yuan Duan, Ren-Jie Zhu, Ying-Ying Jia, Jia-Xin Chen, Xiao-Ting Huang, Shi-Hao Tang, Ke Yu, Wei Shi, Xiao-Feng Chen, Feng Jiang, Ruo-Han Hao, Yunlong Liu, Zhongbo Liu, Yan Guo, and Tie-Lin Yang

Journal: The American Journal of Human Genetics

Doi: doi.org/10.1016/j.ajhg.2024.11.005

Products & Services: Custom DNA/RNA Oligos Oligo pool

Mismatch prime editing gRNA increased efficiency and reduced indels

Authors: Jidong Fei , Dongdong Zhao , Caiyi Pang , Ju Li , Siwei Li , Wentao Qiao , Juan Tan , Changhao Bi , Xueli Zhang

Journal: Nat Commun

PubMed ID: 39747083

Doi: 10.1038/s41467-024-55578-z

Products & Services: Synthetic sgRNA and crRNA Service

Salivary elicitor disulffde isomerase from Nilaparvata lugens targets host rice UDP-glucose epimerase 2 to induce plant defenses

Authors: Jianmei Fu , Zhichang Zhao , Jichao Fang , Rui Ji

Journal: Plant Stress

Doi: doi.org/10.1016/j.stress.2025.100744

Products & Services: Polyclonal Antibody Services

Energy-guided accumulated mutation strategy achieves a highly efficient polyethylene terephthalate-degrading enzyme

Authors: Zhi Wang, Jiaxing Zhang, Shengping You, Rongxin Su, Wei Qi

Journal: Biochemical Engineering Journal

Doi: 10.1016/j.bej.2025.109708

Products & Services: Proteins, Expression, Isolation and Analysis

A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by C-type lectin pathway-mediated tumor associated macrophages repolarizing

Authors: Yongliang Tong , Runqiu Chen , Xinrong Lu , Cuiying Chen , Guiqin Sun , Xiaolu Yu , Shaoxian Lyu , Meiqing Feng , Yiru Long , Likun Gong , Li Chen

Journal: Int J Biol Macromol

PubMed ID: 39824395

Doi: 10.1016/j.ijbiomac.2025.139953

Products & Services: Gene Synthesis

Restoring tumor antigenicity activates the “bystander” T cell immune cycle

Authors: Yifan Yang , Qiumin Yu , Haoyu Zhang , Yuchen Liu , Hexuan Wang , Ningyi Yang , Yulian Shi , Wanli Zhang , Zijie Wu , Shitong Huang , Wenbin Xie , Ran Duan , Qiuli Mao , Xupeiyao Shi , Zheng Gao , Xiaoning Wang , Hanlin Guo , Lingxiao Chen , Yi Han , Ximing Li , Liyuan Chen , Siqi Tang , Ying Fan , Wenbing Yao , Hong Tian , Xiangdong Gao

Journal: J Control Release

PubMed ID: 39894265

Doi: 10.1016/j.jconrel.2025.01.094

Products & Services: Gene Synthesis

Developing orthogonal fluorescent RNAs for photoactive dual-color imaging of RNAs in live cells

Authors: Peng Yin , Chunzheng Huang , Li Zhang , Zhenzhen Li , Caijun Zhong , Shi Kuang , Chunyang Lei , Yan Huang , Zhou Nie

Journal: Angew Chem Int Ed Engl

PubMed ID: 39801450

Doi: 10.1002/anie.202424060

Products & Services: Plasmid DNA Preparation

Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy

Authors: Nailin Yang , Shumin Sun , Jiachen Xu , Fei Gong, Huali Lei , Yu Hao , Zifan Pei , Chenya Wang , Qiao Yu , Jihu Nie , Nan Jiang , Caifang Ni , Liang Cheng

Journal: Adv Mater

PubMed ID: 10.1002/adma.202414929

Doi: 10.1002/adma.202414929

Products & Services: Proteins, Expression, Isolation and Analysis

Computational design, expression, and characterization of a Plasmodium falciparum multi-epitope, multi-stage vaccine candidate (PfCTMAG)

Authors: Joan A Chick, Nadege N Abongdia, Robert A Shey, Tobias O Apinjoh

Journal: Heliyon

PubMed ID: 39906795

Doi: 10.1016/j.heliyon.2025.e42014

Products & Services: Bacterial Expression

TET2-mediated ECM1 hypomethylation promotes the neovascularization in active proliferative diabetic retinopathy

Authors: Chunyang Cai, Chufeng Gu, Shuai He, Chunren Meng, Dongwei Lai, Jingfa Zhang, Qinghua Qiu