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Accurate Mapping of 5-Glyceryl-methylcytosine Using Nanopore Sequencing
Authors: Linting Wang, Baodan He, Zixin Wang, Liting Kang, Jianhuang Xue, Shuanghong Yan
Journal: Anal Chem
PubMed ID: 40314134
Doi: 10.1021/acs.analchem.5c00845
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De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses
Authors: Xiao-Qi Liu, Pan Li, Bao-Qing Gao, Heng-Le Zhu, Liang-Zhong Yang, Yang Wang, Yu-Yao Zhang, Hao Wu, Yu-Hang Pan, Lin Shan, Hongtao Yu, Li Yang, Ling-Ling Chen
Journal: Cell
PubMed ID: 40436014
Doi: 10.1016/j.cell.2025.05.003
Products & Services: Custom RNAi Services   
Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring
Authors: Xiangwei Wu, Huasong Ai, Junxiong Mao, Hongyi Cai, Lu-Jun Liang, Zebin Tong, Zhiheng Deng, Qingyun Zheng, Lei Liu, Man Pan
Journal: nature COMMUNICATION
PubMed ID: 40341121
Doi: doi.org/10.1038/s41467-025-59569-6
PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma
Authors: Binfeng Liu, Wei Li, Wenchao Zhang, Chengyao Feng, Lu Wan, Shasha He, Ruiling Xu, Zheng Fu, Zhongyue Liu, Haodong Xu, Xin Jin, Chao Tu, Zhihong Li
Journal: Signal Transduct Target Ther
PubMed ID: 40393983
Doi: 10.1038/s41392-025-02250-7
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Fe(III)−H2O2 as an Alternative Oxidant for Catalytic Sulfoxidation in Cytochrome P450 Enzymes: Combined Theoretical and Experimental Evidence
Authors: Musen Li, Langxing Liao, Zhihui Jiang, Zongyu Bao, Shengbiao Ji, Binju Wang
Journal: ACS Catalysis
Doi: doi.org/10.1021/acscatal.5c01673
Products & Services: Gene Synthesis   Codon Optimization   
A general assay platform to study protein pharmacology using ligand-dependent structural dynamics
Authors: Daniel A Ciulla, Patricia K Dranchak, Mahesh Aitha, Renier H P van Neer, Divia Shah, Ravi Tharakan, Kelli M Wilson, Yuhong Wang, John C Braisted, James Inglese
Journal: Nature Communication
PubMed ID: 40346061
Doi: 10.1038/s41467-025-59658-6
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Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites
Authors: Thomas H Ambrosi, Sahar Taheri, Kun Chen, Rahul Sinha, Yuting Wang, Ethan J Hunt, L Henry Goodnough, Matthew P Murphy, Holly M Steininger, Malachia Y Hoover, Franco Felix, Kelly C Weldon, Lauren S Koepke, Jan Sokol, Daniel Dan Liu, Liming Zhao, Stephanie D Conley, Wan-Jin Lu, Maurizio Morri, Norma F Neff, Noelle L Van Rysselberghe, Erika E Wheeler, Yongheng Wang, J Kent Leach, Augustine Saiz, Aijun Wang, George P Yang, Stuart Goodman, Julius A Bishop, Michael J Gardner, Derrick C Wan, Irving L Weissman, Michael T Longaker, Debashis Sahoo, Charles K F Chan
Journal: Cell Stem Cell
PubMed ID: 40118065
Doi: 10.1016/j.stem.2025.02.013
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DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway
Authors: Chunyang Cai, Chufeng Gu, Chunren Meng, Yujie Wang, Qingquan Wei, Shuai He, Dongwei Lai, Xingyun Wang, Tengfei Wang, Qinghua Qiu
Journal: Clinical epigenetics
PubMed ID: 40380281
Doi: 10.1186/s13148-025-01874-4
TrkC protects against osteoarthritis progression by maintaining articular cartilage homeostasis
Authors: Yongyun Chang, Keyu Kong, Hua Qiao, Minghao Jin, Xinru Wu, Wenxuan Fan, Jingwei Zhang, Yansong Qi, Yongsheng Xu, An Qin, Zanjing Zhai, Huiwu Li
Journal: International journal of biological sciences
PubMed ID: 40520017
Doi: 10.7150/ijbs.108832
Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1
Authors: Seow Theng Ong, Young-Woo Nam, Joshua A Nasburg, Alena Ramanishka, Xuan Rui Ng, Zhong Zhuang, Stephanie Shee Min Goay, Hai M Nguyen, Latika Singh, Vikrant Singh, Alicia Rivera, M Elaine Eyster, Yang Xu, Seth L Alper, Heike Wulff, Miao Zhang, K George Chandy
Journal: Proc Natl Acad Sci U S A
PubMed ID: 40294255
Doi: 10.1073/pnas.2425494122
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BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner
Authors: Xianyang Liu, Shuhao Zeng, Jiayu Meng, Qian Zhou, Fan Cao, Baorui Chu, Chao Wu, Yakun Wang, Hui Feng, Xiaorui Bi, Xinyuan Chen, Wenxian Yang, Meng Tian, Hui Yang, Ke Hu, Shengping Hou
Journal: Theranostics
Doi: 10.7150/thno.110122
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Teleost GSDMEc regulates GSDMEa-mediated pyroptos
Authors: Hang Xu, Meng Wu, Yujian Wang, Yaoming Jiao, Yuan Chen, Zihao Yuan, Li Sun
Journal: J Adv Res
PubMed ID: 40210150
Doi: doi.org/10.1016/j.jare.2025.04.007
Development of a highly sensitive C1QC-targeting aptamer and its application in a modified antibody-aptamer sandwich biosensor for C1QC biomarker detection
Authors: Wenwei Wu, Lixia Qian, Jie Shen, Hongmei Li, Liang-cheng Li
Journal: Sensors and Actuators: B. Chemical
Doi: doi.org/10.1016/j.snb.2025.137828
Products & Services: Single-Stranded DNA Synthesis   
Developmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition
Authors: Meihui Tao, Li Wang, Chaoyue Chen, Mengfan Tang, Yanping Wang, Jingyue Zhang, Xi Zhao, Qinyu Feng, Junfa Chen, Wei Yan, Rong Lin, Yu Fu
Journal: Journal of Advanced Research
PubMed ID: 40288675
Doi: 10.1016/j.jare.2025.04.030
Products & Services: Mammalian Expression   Recombinant Proteins   
An evolutionarily unique viral RdRP suggests a common dual-function feature of the priming element
Authors: Hengxia Jia, Shunli Liu, Guibo Rao, Qiaojie Liu, Jiqin Wu, Sheng Cao, Peng Gong
Journal: Sci Adv
PubMed ID: 40249801
Doi: 10.1126/sciadv.adv9640
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Identification of RC3H1 as antiviral host factor binding to the non-structural protein 1 of Influenza A virus via a 3-stage computational pipeline and cell-based analysis
Authors: Swee Teng Teo , Shamima Rashid , Kong Yen Liew , Kah Man Lai , Teng Ann Ng , Jifeng Jiao , Chee Keong Kwoh , Yee-Joo Tan
Journal: Virology Journal
PubMed ID: 40287742
Doi: 10.1186/s12985-025-02746-2
Products & Services: ORF cDNA Clones/MolecularCloud   
Fused exosomal targeted therapy in periprosthetic osteolysis through regulation of bone metabolic homeostasis
Authors: Tianliang Ma, Qimeng Liu, Zheyu Zhang, Jiangyu Nan, Guanzhi Liu, Yute Yang, Yihe Hu, Jie Xie
Journal: Bioactive Materials
PubMed ID: 40248188
Doi: doi.org/10.1016/j.bioactmat.2025.04.006
N-Terminal random curl-tandam α-helical peptide 7W: A potent antibacterial and anti-inflammatory dual-effect agent through tryptophan substitution
Authors: Jietao Lou, Xinyi Wu, Wenwen Ji, Jiaye Yu, Yanyan Xu, Wanyang Xiao, Weijie Lu, Kaiyun Xin, Tianbao Chen, Qidong Tang, Guang Liang, Yitian Gao, Di Wu
Journal: Eur J Med Chem
PubMed ID: 40319576
Doi: 10.1016/j.ejmech.2025.117686
Products & Services: Peptide Synthesis   
Phosphorylation dependent charge block regulate the relaxation of nuclear speckle networks
Authors: Mengjun Zhang, Zhuang Gu, Yingtian Sun, Yichen Dong, Junlin Chen, Li Shu, Suibin Ma, Jierui Guo, Yuhang Liang, Qingming Qu, Ning Fang, Chuan-Qi Zhong, Yifan Ge, Zhongwen Chen, Shaohui Huang, Xin Zhang, Bo Wang
Journal: Mol Cell
PubMed ID: 40233760
Doi: 10.1016/j.molcel.2025.03.016
Targeted Delivery of mRNA with Polymer−Lipid Nanoparticles for In Vivo Base Editing
Authors: Qimingxing Chen, Yan Chang, Xiaoyan He, Yan Ding, Runyuan Wang, Ran Luo, Jialu Yuan, Jiabei Chen, Guisheng Zhong, Huiying Yang, Jia Chen, Jianfeng Li
Journal: ACS Nano
PubMed ID: 39962883
Doi: 10.1021/acsnano.4c14041
Fullerol Initiates Stem Cell–Nanomaterials Interactions for Enhanced Tissue Regeneration via Clathrin-Mediated Endocytosis and Nuclear Factor Erythroid 2-Related Factor 2 Signaling
Authors: Haoyang Liu, Yue Zhu, Weixu Chen, Renwang Sheng, Chuanquan Liu, Yuzhi Sun, Jia Liu, Mingyue Wang, Jun Lu, Jialin Chen, Wei Zhang
Journal: ACS Applied Materials & Interfaces
Doi: 10.1021/acsami.5c01731
Products & Services: Recombinant Proteins   
PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance
Authors: Anoop S Chauhan, Matthew J W Mackintosh, Joseph Cassar, Alexander J Lanz, Mohammed Jamshad, Hannah L Mackay, Alexander J Garvin, Alexandra K Walker, Satpal S Jhujh, Teresa Carlomagno, Aneika C Leney, Grant S Stewart, Joanna R Morris
Journal: Nature Communication
PubMed ID: 40229270
Doi: 10.1038/s41467-025-56974-9
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Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration
Authors: Zhuo Li, Zhengnan Guo, Zhengmeng Yang, Boguang Yang, Yuan Hu, Xian Xie, Zhixian Zong, Zekun Chen, Kunyu Zhang, Pengchao Zhao, Gang Li, Xuefeng Yang, Liming Bian
Journal: Cell Rep
PubMed ID: 40272981
Doi: 10.1016/j.celrep.2025.115611
Products & Services: Peptide Synthesis   
Inhibiting Chemotherapy Immune Tolerance and Reversing Tumor Microenvironment by Macrophage-Targeted Nanohybrid Systems for Enhancing Tumor Chemo-Immunotherapy
Authors: You-Teng Qin, Zhi-Yong Rao, Jia-Xin An, Shi-Man Zhang, Yu-Zhang Wang, Ting Pan, and Xian-Zheng Zhang
Journal: Advanced Functional Materials
Doi: doi.org/10.1002/adfm.202501954
Products & Services: Recombinant Proteins   
Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs
Authors: Canrong Wu, Chao Zhang, Sanshan Jin, James Jiqi Wang, Antao Dai, Jiuyin Xu, Heng Zhang, Xuemei Yang, Xinheng He, Qingning Yuan, Wen Hu, Youwei Xu, Mingwei Wang, Yi Jiang, Dehua Yang, H Eric Xu
Journal: Cell Discov
PubMed ID: 11962085
Doi: 10.1038/s41421-025-00779-z
Products & Services: Catalog Peptides   
Using Regular Porous Membrane-Based Blood−Brain Barrier Model to Screen Brain-Targeted Drugs with Nanochannel Electrochemistry
Authors: Yafeng Wu,Zixuan Chen,Fengxiang Chen,Juan Su,Jianyu Han,Songqin Liu
Journal: Anal Chem
PubMed ID: 40183921
Doi: 10.1021/acs.analchem.5c00365
Products & Services: Peptide Synthesis   
Molecular mechanisms of the viral encoded chaperone 100K in capsid folding and assembly of adenovirus
Authors: Haining Li , Luyuan Shao , Zhe Liu , Qi Liu , Ye Xiang
Journal: Nat Commun
PubMed ID: 40301360
Doi: 10.1038/s41467-025-59301-4
Molecular determinants for the association of human hormone-sensitive lipase with lipid droplets
Authors: Han Peng, Qikui Xu, Ting Zhang, Jiakai Zhu, Jinheng Pan, Xiaoyu Guan, Shan Feng, Jianping Wu, Qi Hu
Journal: Nature Communication
PubMed ID: 40221426
Doi: 10.1038/s41467-025-58887-z
Self-oxygenating nanoplatform integrating CRISPR/Cas9 gene editing and immune activation for highly efficient photodynamic therapy
Authors: Shi-Cheng Tian, Xun-Huan Song, Ke-Ke Feng, Cheng-Lei Li, Yi-Fan Tu, Yong-Shan Hu, Jing-Wei Shao
Journal: JOURNAL OF COLLOID AND INTERFACE SCIENCE
PubMed ID: 40262200
Doi: 10.1016/j.jcis.2025.137632
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The Atypical Pectin Methylesterase Family Member PME31 Promotes Seedling Lipid Droplet Utilization
Authors: Sarah Hamade, Melissa S Traver , Bonnie Bartel
Journal: Plant Direct
PubMed ID: 40212536
Doi: doi.org/10.1002/pld3.70054
Products & Services: Catalog Antibody   
Peptide-conjugated alginate fiber: A skeletal muscle regenerative scaffold
Authors: Yajun Li, Yueren Wu, Tong Wu, Can Zhang, Jianwu Dai, Jianping Tang, Lin Li, Liyang Shi
Journal: Carbohydrate Polymers
PubMed ID: 39978892
Doi: 10.1016/j.carbpol.2025.123299
Products & Services: Catalog Peptides   
Nanosized Shikonin Disrupts Tumor-cell Mismatch Repair and Synergizes with Manganese to Sensitize Squamous Carcinoma to Immunotherapy
Authors: Shan Yu, Jingyuan Li, Jie Zhang, Guozhong Zeng, Bin Zeng, Shuyuan Song, Zhentao Lao, Haolin Chen, Zhenfu Wen, Zeyu Yang, Xiang Li, Kan Li, Le Yang, Hong Liu, Lixin Liu, Guiqing Liao, Yongming Chen, Yujie Liang
Journal: ACS Nano
PubMed ID: 40190094
Doi: 10.1021/acsnano.4c17090.
Cryo-EM structures of the small-conductance Ca2+-activated KCa2.2 channel
Authors: Young-Woo Nam, Dohyun Im, Ana Santa Cruz Garcia, Marios L Tringides, Hai Minh Nguyen, Yan Liu, Razan Orfali, Alena Ramanishka, Grigore Pintilie, Chih-Chia Su, Meng Cui, Diomedes E Logothetis, Edward W Yu, Heike Wulff, K George Chandy, Miao Zhang
Journal: Nat Commun
PubMed ID: 40246884
Doi: /10.1038/s41467-025-59061-1
Products & Services: Gene Synthesis   
Inhibition of CHI3L1 attenuates excessive autophagy in intestinal epithelial cells to reduce the severity of necrotizing enterocolitis
Authors: Yihui Li, Wenqiang Sun, Xinyun Jin, Huiwen Li, Xue Liu, Jingtao Bian, Xueping Zhu
Journal: Cell Death Discov
PubMed ID: 40188090
Doi: 10.1038/s41420-025-02443-7.
2A-biohydrogels accelerate diabetic wound healing by promoting M2 macrophage polarization and functionalized mitochondrial transfer to endothelial cells
Authors: Hao Wang, Min Zhou, Yifeng Ruan, Yifei Shen, Ziqi Qin, Xingbo Wu, Huiling Ling, Wushuang Ye, Yongfu Wang, Xueqi Gan
Journal: Chemical Engineering Journal
Doi: 10.1016/j.cej.2025.163130
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Astragalus Polysaccharides Ameliorate Diabetic Bladder Dysfunction via Normalization of Neuromuscular Conduction
Authors: Shaochan Liang, Siyuan Xu, Shenglian Ye, Lang Liang, Hongliang Li, Jiaye Liu, Yao Zhang, Feng Zou, Xiaodan Liang, Bo Tan, Hongying Cao
Journal: J Agric Food Chem
PubMed ID: 40032633
Doi: 10.1021/acs.jafc.4c11577
The E3 ubiquitin ligase SlATL2 suppresses tomato immunity by promoting SlCSN5a degradation during Pseudomonas syringae pv. tomato DC3000 infection
Authors: Yujie Dai, Xiaodan Li, Yeling He, Liya Zhu, Yan Bi, Fengming Song, Dayong Li
Journal: Horticulture research
PubMed ID: 40303438
Doi: 10.1093/hr/uhaf078
Products & Services: Glutathione Resin   
Expediting Genome Synthesis of Corynebacterium glutamicum with An Artificial Chromosome Vector
Authors: Zhanhua Zhang, Peixiong Hong, Zebin Li, Baitao Li, Tai Chen, Yue Shen, Xiaofeng Yang, Yanrui Ye, Yun Wang, Zhanglin Lin
Journal: Trends Biotechnol
PubMed ID: 40155267
Doi: 10.1016/j.tibtech.2025.02.019
The structure and function of the ghrelin receptor coding for drug actions
Authors: Yuki Shiimura, Dohyun Im, Ryosuke Tany, Hidetsugu Asada, Ryoji Kise, Eon Kurumiya, Hideko Wakasugi-Masuho, Satoshi Yasuda, Kazuma Matsui, Jun-Ichi Kishikawa, Takayuki Kato, Takeshi Murata, Masayasu Kojima, So Iwata, Ikuo Masuho
Journal: Nat Struct Mol Biol
PubMed ID: 39833471
Doi: 39833471
Products & Services: Gene Synthesis   
Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator
Authors: Demeng Sun, Xiang Li, Qingning Yuan, Yuanxia Wang, Pan Shi, Huanhuan Zhang, Tao Wang, Wenjing Sun, Shenglong Ling, Yuanchun Liu, Jinglin Lai, Wenqin Xie, Wanchao Yin, Lei Liu, H. Eric Xu, Changlin Tian
Journal: Cell Res
PubMed ID: 40118988
Doi: doi.org/10.1038/s41422-025-01095-7
Enhancing the Anticancer Activity of a Carcinoma-Directed Peptide–HLA-I Fusion Protein by Armoring with Mutein IFNα
Authors: Douwe Freerk Samplonius , Anne Paulien van Wijngaarden , Lisanne Koll , Xiurong Ke , Wijnand Helfrich
Journal: Int J Mol Sci
PubMed ID: 40243928
Doi: ijms26073178
Products & Services: Gene Synthesis   
A Functional 3D Biomimetic Osteon Accelerates Bone Regeneration
Authors: Chenxu Zhu, Zexi Li, Xubin Qiu, Baizhen Zhao, Huan Wang, Lijie Wang, Ming Zhuang, Jinbo Liu, Fengxuan Han, Bin Li
Journal: ADVANCED FUNCTIONAL MATERIALS
Doi: 10.1002/adfm.202500603
Machine Learning-Aided Identification of Fecal Extracellular Vesicle microRNA Signatures for Noninvasive Detection of Colorectal Cancer
Authors: Zhaowei Zhang, Xuyang Liu, Chuanyue Peng, Rui Du, Xiaoqin Hong, Jia Xu, Jiaming Chen, Xiaomin Li, Yujing Tang, Yuwei Li, Yang Liu, Chen Xu, Dingbin Liu
Journal: ACS Nano
PubMed ID: 40033785
Doi: 10.1021/acsnano.4c16698
GPR132 regulates the function of NK cells through the Gαs/CSK/ZAP70/NF-κB signaling pathway as a potential immune checkpoint
Authors: Xinhui Hui, Min Xue, Yaojun Ren, Yiran Chen, Xuenan Chen, Muhammad Asad Farooq, Yuzhou Ji, Weirong Zhan, Yunhe Huang, Bingtan Du, Jie Yao, Yixin Duan, Wenzheng Jiang
Journal: Sci Adv
PubMed ID: 40043109
Doi: doi/10.1126/sciadv.adr9395
Manganese-Driven Plasmid Nanofibers Formed In Situ for Cancer Gene Delivery and Metalloimmunotherapy
Authors: Jiexin Li, Ruiqi Yang, Chen Zhang, Jonathan F Lovell, Yumiao Zhang
Journal: J Am Chem Soc
PubMed ID: 40065259
Doi: 10.1021/jacs.4c18511
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Examining the Role of Threonine Phosphorylation in Ubiquitin’s Function Using Chemical Protein Synthesis
Authors: Bingji Wang, Chuntong Li, Fangyu Zhao, Luyu Shi, Xu Li, Yijie Liu, Shuzhe Sun, Ligong Yuan, Maoshen Sun, Yingyue Zhang, Jing Shi, Lu-Jun Liang
Journal: JACS Au
Doi: doi/10.1021/jacsau.5c00067
Meiotic crossovers revealed by differential visualization of homologous chromosomes using enhanced haplotype oligo-painting in cucumber
Authors: Yafeng Wu,Zixuan Chen,Fengxiang Chen,Juan Su,Jianyu Han,Songqin Liu
Journal: Plant Biotechnol J
PubMed ID: 39661709
Doi: 10.1111/pbi.14546
Products & Services: Oligo pool   
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants
Authors: Shouya Feng, Matthew C Wierzbowski, Katja Hrovat-Schaale, Andreas Dumortier, Yaoyuan Zhang, Maria Zyulina, Paul J Baker, Thomas Reygaerts, Annemarie Steiner, Dominic De Nardo, Dhanya Lakshmi Narayanan, Florian Milhavet, Alberto Pinzon-Charry, Juan Ignacio Arostegui, Raju P Khubchandani, Matthias Geyer, Guilaine Boursier, Seth L Masters
Journal: Nature Immunology
PubMed ID: 39930093
Doi: 10.1038/s41590-025-02088-9
Products & Services: Mutagenesis Services   
SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair
Authors: Alexander J Garvin, Alexander J Lanz, George E Ronson, Matthew J W Mackintosh, Katarzyna Starowicz, Alexandra K Walker, Yara Aghabi, Hannah MacKay, Ruth M Densham, Jai S Bhachoo, Aneika C Leney, Joanna R Morris
Journal: Mol Cell
PubMed ID: 40054443
Doi: 10.1016/j.molcel.2025.02.004

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