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Fluorescence Sensing of Eclampsia Biomarkers via the Immunosorbent Atom Transfer Radical Polymerization Assay

Authors: Nan Ma, Jian Zhang, Jinming Kong, Xueji Zhang

Journal: Anal Chem

PubMed ID: 38728011

Doi: 10.1021/acs.analchem.4c00110

Products & Services: Proteins, Expression, Isolation and Analysis

Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement

Authors: Seiji Watanabe, Kangsa Amporndanai, Raheela Awais, Caroline Latham, Muhammad Awais, Paul M O'Neill, Koji Yamanaka, S Samar Hasnain

Journal: Sci Rep

PubMed ID: 38802492

Doi: 10.1038/s41598-024-62903-5

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Molecular characteristics of Echinococcus multilocularis FABP1 and its regulatory functions on murine macrophages

Authors: Xiang Li, Peng Liao, Wenjing Zhou, Xinqi Yang, Bin Ye

Journal: Acta Trop

PubMed ID: 38729330

Doi: 10.1016/j.actatropica.2024.107247

Products & Services: Proteins, Expression, Isolation and Analysis

Development and application of a cycleave dual-probe fluorescence quantitative PCR method for simultaneous detection of Mycoplasma gallisepticum ts-11 vaccine strain and non-ts-11 strains

Authors: Xue Wang, Nana Sun, Meng Wang, Hui Wang, Yuhan Liu, Hao Shi, Hao Zhu, Peidong Li, Fuyou Zhang, Tianyao Yang, Zhaoyang Li, Chunguo Liu

Journal: Poult Sci

PubMed ID: 38878745

Doi: 10.1016/j.psj.2024.103907

Products & Services: PCR Cloning and Subcloning

Identification of a novel neurovirulence factor encoded by the cryptic orphan gene UL316 of herpes simplex virus 1

Authors: Akihisa Kato, Ryoji Iwasaki, Kousuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Tohru Natsume, Hideo Kusano, Shungo Adachi, Shuichi Kawano, Yasushi Kawaguchi

Journal: J Virol

PubMed ID: 38819171

Doi: 10.1128/jvi.00747-24

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Structural insights into the molecular mechanism of phytoplasma immunodominant membrane protein

Authors: Chang Yi Liu, Han Pin Cheng, Chan Pin Lin, Yi Ting Liao, Tzu Ping Ko, Shin Jen Lin, Shih Shun Lin, Hao Ching Wang

Journal: IUCrJ

PubMed ID: 38656311

Doi: 10.1107/S2052252524003075

Products & Services: Molecular Biology Reagents

Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo

Authors: Anke Vermehren-Schmaedick, Myron Peto, Wendy Wagoner, Kami E Chiotti, Elizabeth Ramsey, Xiaoyan Wang, Shauna Rakshe, Jessica Minnier, Rosalie Sears, Paul Spellman, Shiuh-Wen Luoh

Journal: PLoS ONE

PubMed ID: 38722955

Doi: 10.1371/journal.pone.0302856

Products & Services: PCR Cloning and Subcloning

A new strategy to generate nanobodies for the coumaphos based on the synthesized nanobody libraries

Authors: Ruyu Fang, Yingxue Li, Fei Liu, Yifan Liang, Yu Wang, Guohua Zhong, Zhenlin Xu, Bruce D Hammock, Hong Wang

Journal: Food Chem

PubMed ID: 38833869

Doi: 10.1016/j.foodchem.2024.139684

Imprinted lncRNA KCNQ1OT1 regulates CDKN1C expression through promoter binding and chromatin folding in pigs

Authors: Yongfeng Zhou, Hao Yu, Daoyu Zhang, Zhengzhu Wang, Qi Li, Xinglan An, Sheng Zhang, Ziyi Li

Journal: Gene

PubMed ID: 38772516

Doi: 10.1016/j.gene.2024.148590

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of phosphorylated small ORF-encoded peptides in Hep3B cells by LC/MS/MS

Authors: Mingbo Peng, Yutian Zhou, Cuihong Wan

Journal: J Proteomics

PubMed ID: 38823442

Doi: 10.1016/j.jprot.2024.105214

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Analysis of the molecular basis for the non-amylolytic and non-proteolytic nature of Aspergillus vadensis CBS 113365

Authors: Dujuan Liu, Sandra Garrigues, Helena Culleton, Vincent A McKie, Ronald P de Vries

Journal: N Biotechnol

PubMed ID: 38697469

Doi: 10.1016/j.nbt.2024.04.003

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Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis

Authors: Zhixin Ma, Yu Sun, Yang Yu, Wenjun Xiao, Zhijie Xiao, Tianyu Zhong, Xi Xiang, Zhigang Li

Journal: Cell Commun Signal

PubMed ID: 38802814

Doi: 10.1186/s12964-024-01669-9

Identification and characterisation of novel CAR-T cells to target IL13Rα2 positive human glioma in vitro and in vivo

Authors: Pamela Leland, Heba Degheidy, Ashley Lea, Steven R Bauer, Raj K Puri, Bharat H Joshi

Journal: Clin Transl Med

PubMed ID: 38685487

Doi: 10.1002/ctm2.1664

Products & Services: Codon Optimization

A potent Henipavirus cross-neutralizing antibody reveals a dynamic fusion-triggering pattern of the G-tetramer

Authors: Pengfei Fan, Mengmeng Sun, Xinghai Zhang, Huajun Zhang, Yujiao Liu, Yanfeng Yao, Ming Li, Ting Fang, Bingjie Sun, Zhengshan Chen, Xiangyang Chi, Li Chen, Cheng Peng, Zhen Chen, Guanying Zhang, Yi Ren, Zixuan Liu, Yaohui Li, Jianmin Li, Entao Li, Wuxiang Guan, Shanshan Li, Rui Gong, Kaiming Zhang, …Sandra Chiu

Journal: Nat Commun

PubMed ID: 38773072

Doi: 10.1038/s41467-024-48601-w

Products & Services: Proteins, Expression, Isolation and Analysis

Poc1 bridges basal body inner junctions to promote triplet microtubule integrity and connections

Authors: Marisa D Ruehle, Sam Li, David A Agard, Chad G Pearson

Journal: J Cell Biol

PubMed ID: 38743010

Doi: 10.1083/jcb.202311104

Products & Services: Molecular Biology Reagents

CRISPR/Cas9-Mediated Knockout of the Lycopene ε-Cyclase for Efficient Astaxanthin Production in the Green Microalga

Authors: Jacob Sebastian Kneip, Niklas Kniepkamp, Junhwan Jang, Maria Grazia Mortaro, EonSeon Jin, Olaf Kruse, Thomas Baier

Journal: Plants (Basel)

PubMed ID: 38794462

Doi: 10.3390/plants13101393

Products & Services: PCR Cloning and Subcloning Gene Synthesis

Structure and genome editing of type I-B CRISPR-Cas

Authors: Meiling Lu, Chenlin Yu, Yuwen Zhang, Wenjun Ju, Zhi Ye, Chenyang Hua, Jinze Mao, Chunyi Hu, Zhenhuang Yang & Yibei Xiao

Journal: Nat Commun

PubMed ID: 38750051

Doi: 10.1038/s41467-024-48598-2

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Quercetin induces itaconic acid-mediated M1/M2 alveolar macrophages polarization in respiratory syncytial virus infection

Authors: Li An , Qianwen Zhai , Keyu Tao , Yingcai Xiong , Weiying Ou , Ziwei Yu , Xingyu Yang , Jianjian Ji , Mengjiang Lu

Journal: Phytomedicine

PubMed ID: 38797031

Doi: 10.1016/j.phymed.2024.155761

Products & Services: Proteins, Expression, Isolation and Analysis

Imaging the dynamics of messenger RNA with a bright and stable green fluorescent RNA

Authors: Fangting Zuo, Li Jiang, Ni Su, Yaqiang Zhang, Bingkun Bao, Limei Wang, Yajie Shi, Huimin Yang, Xinyi Huang, Ruilong Li, Qingmei Zeng, Zhengda Chen, Qiuning Lin, Yingping Zhuang, Yuzheng Zhao, Xianjun Chen, Linyong Zhu & Yi Yang

Journal: nature chemical biology

PubMed ID: 38783134

Doi: 10.1038/s41589-024-01629-x

Products & Services: Single-Stranded DNA Synthesis

Novel Multi-Antigen Orf-Virus-Derived Vaccine Elicits Protective Anti-SARS-CoV-2 Response in Monovalent and Bivalent Formats

Authors: Dominique Julien Burri, Louis Renz, Melanie Mueller, Felix Pagallies, Ute Klinkhardt, Ralf Amann, Madiha Derouazi

Journal: Vaccines (Basel)

PubMed ID: 38793740

Doi: 10.3390/vaccines12050490

Products & Services: Recombinant Proteins

A fluorescence anisotropy-based competition assay to identify inhibitors against ricin and Shiga toxin ribosome interactions

Authors: Arkajyoti Dutta, Zoltan Szekely, Hakan Guven, Xiao-Ping Li, John E McLaughlin, Nilgun E Tumer

Journal: Anal Biochem

PubMed ID: 38825159

Doi: 10.1016/j.ab.2024.115580

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM

Authors: Weicheng Li, Haoyun Yang, Kye Stachowski, Andrew S Norris, Katie Lichtenthal, Skyler Kelly, Paul Gollnick, Vicki H Wysocki, Mark P Foster

Journal: biorxiv

PubMed ID: 38746386

Doi: 10.1101/2024.05.02.592192

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Citrus psorosis virus 24K protein inhibits the processing of miRNA precursors by interacting with components of the biogenesis machinery

Authors: Facundo E Marmisolle, María B Borniego, Damián A Cambiagno, Lucia Gonzalo, María L García, Pablo A Manavella, Carmen Hernández, Carina A Reyes

Journal: Microbiol Spectr

PubMed ID: 38785434

Doi: 10.1128/spectrum.03513-23

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LINE-1 retrotransposons contribute to mouse PV interneuron development

Authors: Gabriela O Bodea, Juan M Botto, Maria E Ferreiro, Francisco J Sanchez-Luque, Jose de Los Rios Barreda, Jay Rasmussen, Muhammed A Rahman, Laura R Fenlon, Natasha Jansz, Carolina Gubert, Patricia Gerdes, Liviu-Gabriel Bodea, Prabha Ajjikuttira, Darwin J Da Costa Guevara, Linda Cumner, Charles C Bell, Peter Kozulin, Victor Billon, Santiago Morell, Marie-Jeanne H C Kempen, Chloe J Love, Karabi Saha, Lucy M Palmer, Adam D Ewing, Dhanisha J Jhaveri, Sandra R Richardson, Anthony J Hannan, Geoffrey J Faulkner

Journal: Nat Neurosci

PubMed ID: 38773348

Doi: 10.1038/s41593-024-01650-2

Products & Services: Molecular Biology Reagents

Multifunctional bispecific nanovesicles targeting SLAMF7 trigger potent antitumor immunity

Authors: Manman Zhu, Yongjian Wu, Tianchuan Zhu, Jian Chen, Zhenxing Chen, Hanxi Ding, Siyi Tan, Jianzhong He, Qi Zeng, Xi Huang

Journal: Cancer Immunol Res

PubMed ID: 38819238

Doi: 10.1158/2326-6066.CIR-23-1102

Products & Services: DNA Sequencing

Anti-HIV Humoral Response Induced by Different Anti-Idiotype Antibody Formats: An In Silico and In Vivo Approach

Authors: Valeria Caputo, Ilaria Negri, Louiza Moudoud, Martina Libera, Luigi Bonizzi, Massimo Clementi, Roberta Antonia Diotti

Journal: Int J Mol Sci

PubMed ID: 38891926

Doi: 10.3390/ijms25115737

Products & Services: Molecular Biology Reagents

Cross-reactivity of hantavirus antibodies after immunization with PUUV antigens

Authors: Layaly Shkair, Diksha Sharma, Shaimaa Hamza, Ekaterina Garanina, Venara Shakirova, Ilsiyar Khaertynova, Maria Markelova, Vera Pavelkina, Albert Rizvanov, Svetlana Khaiboullina, Manoj Baranwal, Ekaterina Martynova

Journal: Biotechnol Appl Biochem

PubMed ID: 38779849

Doi: 10.1002/bab.2604

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Elucidation of the Catalytic Sequence of Dihydroorotate Dehydrogenase B from : Evidence for Accumulation of a Flavin Bisemiquinone State in Catalysis

Authors: Corine O Smith, Graham R Moran

Journal: Biochemistry

PubMed ID: 38691339

Doi: 10.1021/acs.biochem.4c00025

Products & Services: Gene Synthesis

Delivery of endolysin across outer membrane of Gram-negative bacteria using translocation domain of botulinum neurotoxin

Authors: Wonbeom Park, Myungseo Park, Jihwan Chun, Jaehyeon Hwang, Suhyun Kim, Nayoon Choi, Soo Min Kim, SeungJoo Kim, Sangwon Jung, Kwan Soo Ko, Dae-Hyuk Kweon

Journal: Int J Antimicrob Agents

PubMed ID: 38795926

Doi: 10.1016/j.ijantimicag.2024.107216

Products & Services: DNA Sequencing

Transcriptome Analysis Reveals the Induction of Apoptosis-Related Genes by a Monoclonal Antibody against a New Epitope of CD99 on T-Acute Lymphoblastic Leukemia

Authors: Nuchjira Takheaw, Kamonporn Kotemul, Ratthakorn Chaiwut, Supansa Pata, Witida Laopajon, Kuntalee Rangnoi, Montarop Yamabhai, Watchara Kasinrerk

Journal: Antibodies (Basel)

PubMed ID: 38804310

Doi: 10.3390/antib13020042

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Development of a Plant-Expressed Subunit Vaccine against Brucellosis

Authors: Daria A Rutkowska, Lissinda H Du Plessis, Essa Suleman, Martha M O'Kennedy, Deepak B Thimiri Govinda Raj, Yolandy Lemmer

Journal: Microorganisms

PubMed ID: 38930429

Doi: 10.3390/microorganisms12061047

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Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations

Authors: Jeannette L Tenthorey, Serena Del Banco, Ishrak Ramzan, Hayley Klingenberg, Chang Liu, Michael Emerman, Harmit S Malik

Journal: biorxiv

PubMed ID: 38765965

Doi: 10.1101/2024.05.07.592993

Products & Services: PCR Cloning and Subcloning

Exploring Syndecan-4 and MLP and Their Interaction in Primary Cardiomyocytes and H9c2 Cells

Authors: Thea Parsberg Støle, Marianne Lunde, Katja Gehmlich, Geir Christensen, William E Louch, Cathrine Rein Carlson

Journal: Cells

PubMed ID: 38891079

Doi: 10.3390/cells13110947

Products & Services: Recombinant Proteins

The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and limits fibrosis by suppressing GPNMB-mediated TGF-β signaling

Authors: Muneera Vakayil, Aisha Y Madani, Maha V Agha, Yasser Majeed, Shahina Hayat, Shameem Yonuskunju, Yasmin Ali Mohamoud, Joel Malek, Karsten Suhre, Nayef A Mazloum

Journal: Sci Rep

PubMed ID: 38789534

Doi: 10.1038/s41598-024-62508-y

Products & Services: Molecular Biology Reagents

Development of a nucleoside-modified mRNA vaccine against clade 2344b H5 highly pathogenic avian influenza virus

Authors: Colleen Furey, Gabrielle Scher, Naiqing Ye, Lisa Kercher, Jennifer DeBeauchamp, Jeri Carol Crumpton, Trushar Jeevan, Christopher Patton, John Franks, Adam Rubrum, Mohamad-Gabriel Alameh, Steven H Y Fan, Anthony T Phan, Christopher A Hunter, Richard J Webby, Drew Weissman, Scott E Hensley

Journal: Nat Commun

PubMed ID: 38782954

Doi: 10.1038/s41467-024-48555-z

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Safety, immunogenicity and efficacy of the self-amplifying mRNA ARCT-154 COVID-19 vaccine: pooled phase 1, 2, 3a and 3b randomized, controlled trials

Authors: Nhân Thị Hồ, Steven G Hughes, Van Thanh Ta, Lân Trọng Phan, Quyết Đỗ, Thượng Vũ Nguyễn, Anh Thị Văn Phạm, Mai Thị Ngọc Đặng, Lượng Viết Nguyễn, Quang Vinh Trịnh, Hùng Ngọc Phạm, Mến Văn Chử, Toàn Trọng Nguyễn, Quang Chấn Lương, Vy Thị Tường Lê, Thắng Văn Nguyễn, Lý-Thi-Lê Trần, Anh Thi Van Luu, Anh Ngoc Nguyen, Nhung-Thi-Hong Nguyen, Hai-Son Vu, Jonathan M Edelman, Suezanne Parker, Brian Sullivan, Sean Sullivan, Qian Ruan, Brenda Clemente, Brian Luk, Kelly Lindert, Dina Berdieva, Kat Murphy, Rose Sekulovich, Benjamin Greener, Igor Smolenov, Pad Chivukula, Vân Thu Nguyễn, Xuan-Hung Nguyen

Journal: Nat Commun

PubMed ID: 38744844

Doi: 10.1038/s41467-024-47905-1

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Substrate Affinity Is Not Crucial for Therapeutic L-Asparaginases: Antileukemic Activity of Novel Bacterial Enzymes

Authors: Anna Ściuk, Kinga Wątor, Izabela Staroń, Paulina Worsztynowicz, Kinga Pokrywka, Joanna Sliwiak, Marta Kilichowska, Kamila Pietruszewska, Zofia Mazurek, Anna Skalniak, Krzysztof Lewandowski, Mariusz Jaskolski, Joanna I Loch, Marcin Surmiak

Journal: Molecules

PubMed ID: 38792133

Doi: 10.3390/molecules29102272

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Biophysical insights into the dimer formation of human Sirtuin 2

Authors: Noa Suzuki, Tsuyoshi Konuma, Takahisa Ikegami, Satoko Akashi

Journal: Protein Sci

PubMed ID: 38647411

Doi: 10.1002/pro.4994

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A Piecewise Design Approach to Engineering a Miniature ACE2 Mimic to Bind SARS-CoV-2

Authors: Yashavantha L Vishweshwaraiah, Brianna Hnath, Jian Wang, Morgan Chandler, Arnab Mukherjee, Neela H Yennawar, Squire J Booker, Kirill A Afonin, Nikolay V Dokholyan

Journal: ACS Appl Bio Mater

PubMed ID: 38700999

Doi: 10.1021/acsabm.4c00222

Products & Services: Proteins, Expression, Isolation and Analysis

Combined effect of SAR-endolysin LysKpV475 with polymyxin B and bacteriophage phSE-5

Authors: Marco Gontijo, Mateus Pereira Teles, Hugo Martins Correia, Genesy Pérez Jorge, Isabella Carolina Rodrigues Santos Goes, Anthony Jhoao Fasabi Flores, Márcia Braz, Lucas de Moraes Ceseti, Priscila Zonzini Ramos, Ivan Rosa E Silva, Pedro Marcus Pereira Vidigal, Jörg Kobarg, Rafael Miguez Couñago, Cristina Elisa Alvarez-Martinez, Carla Pereira, Carmen S R Freire, Adelaide Almeida, Marcelo Brocchi

Journal: Microbiology (Reading)

PubMed ID: 38739436

Doi: 10.1099/mic.0.001462

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Construction and in vitro characterisation of virus-vectored immunocontraceptive candidates derived from felid alphaherpesvirus 1

Authors: Ellen Cottingham, Thurid Johnstone, Paola K Vaz, Carol A Hartley, Joanne M Devlin

Journal: Vaccine

PubMed ID: 38824082

Doi: 10.1016/j.vaccine.2024.05.047

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Amplifiable protein identification via residue-resolved barcoding and composition code counting

Authors: Weiming Guo , Yuan Liu , Yu Han , Huan Tang , Xinyuan Fan , Chu Wang , Peng R Chen

Journal: National Science Review

PubMed ID: 39055168

Doi: 10.1093/nsr/nwae183

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A converged ubiquitin‐proteasome pathway for the degradation of TOC and TOM tail‐anchored receptors

Authors: Meijing Yang , Shuai Chen , Shey-Li Lim , Lang Yang , Jia Yi Zhong , Koon Chuen Chan , Zhizhu Zhao , Kam-Bo Wong , Junqi Wang , Boon Leong Lim

Journal: Journal of integrative plant biology

PubMed ID: 38501483

Doi: doi.org/10.1111/jipb.13645

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Impact of N-Glycosylation on Protein Structure and Dynamics Linked to Enzymatic C–H Activation in the M. oryzae Lipoxygenase

Authors: Chris Whittington, Ajay Sharma, S Gage Hill, Anthony T Iavarone, Brian M Hoffman, Adam R Offenbacher

Journal: Biochemistry

PubMed ID: 38690768

Doi: 10.1021/acs.biochem.4c00109

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Manganese-dependent transcription regulation by MntR and PerR in Thermus thermophilus HB8

Authors: John K Barrows, Kamya A Stubbs, Irina F Padilla-Montoya, Thomas C Leeper, Michael W Van Dyke

Journal: Mol Microbiol

PubMed ID: 38735869

Products & Services: Nucleic Acid Purification & Analysis

Delineating organizational principles of the endogenous L-A virus by cryo-EM and computational analysis of native cell extracts

Authors: Lisa Schmidt, Christian Tüting, Fotis L Kyrilis, Farzad Hamdi, Dmitry A Semchonok, Gerd Hause, Annette Meister, Christian Ihling, Milton T Stubbs, Andrea Sinz, Panagiotis L Kastritis

Journal: Commun Biol

PubMed ID: 38730276

Doi: 10.1038/s42003-024-06204-7

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TALEN-mediated homologous-recombination-based fibroin light chain in-fusion expression system in

Authors: Shihua Yu, Huoqing Zheng, Xiaogang Ye, Xiangping Dai, Xinqiu Wang, Shuo Zhao, Xiaoyan Dai, Boxiong Zhong

Journal: Front Bioeng Biotechnol

PubMed ID: 38832132

Doi: 10.3389/fbioe.2024.1399629

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Identification of Fibrinogen as a Plasma Protein Binding Partner for Lecanemab Biosimilar IgG: Implications for Alzheimer's Disease Therapy

Authors: Jean-Pierre Bellier, Andrea Roman, Caitlyn Christiano, Juliana Au Anzai, Stephanie Moreno, Emily C Campbell, Lucas Godwin, Amy Li, Alan Chen, Sarah M Alan, Adriana Saba, Han Bin Yoo, Hyun-Sik Yang, Jasmeer P Chhatwal, Dennis J Selkoe, Lei Liu

Journal: biorxiv

PubMed ID: 38746192

Doi: 10.1101/2024.05.01.591892

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Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren's syndrome in mice by promoting TEC kinase degradation

Authors: Ya-Qi Yang, Yi-Jun Liu, Wen-Xuan Qiao, Wei Jin, Shun-Wei Zhu, Yu-Xi Yan, Qiong Luo, Qiang Xu

Journal: Acta Pharmacol Sin

PubMed ID: 38744938

Doi: 10.1038/s41401-024-01288-7

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A ferritin nanoparticle vaccine based on the hemagglutinin extracellular domain of swine influenza A (H1N1) virus elicits protective immune responses in mice and pigs

Authors: Pan Tang, Enhui Cui, Jinghua Cheng, Benqiang Li, Jie Tao, Ying Shi, Jiajie Jiao, Enqi Du, Jingyu Wang, Huili Liu

Journal: Front Immunol

PubMed ID: 38835763

Doi: 10.3389/fimmu.2024.1361323

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Radiation-primed TGF-β trapping by engineered extracellular vesicles for targeted glioblastoma therapy

Authors: Ruyu Liang, Hongyu Lu, Haifeng Zhu, Gaofeng Liang, Junxia Zhang, Jun Gao, Tian Tian

Journal: J Control Release

PubMed ID: 38740092

Doi: 10.1016/j.jconrel.2024.05.022

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Library Screening, In Vivo Confirmation, and Structural and Bioinformatic Analysis of Pentapeptide Sequences as Substrates for Protein Farnesyltransferase

Authors: Garrett L Schey, Emily R Hildebrandt, You Wang, Safwan Diwan, Holly A Passetti, Gavin W Potts, Andrea M Sprague-Getsy, Ethan R Leoni, Taylor S Kuebler, Yuk Y Sham, James L Hougland, Lorena S Beese, Walter K Schmidt, Mark D Distefano

Journal: Int J Mol Sci

PubMed ID: 38791363

Doi: 10.3390/ijms25105324

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Production of VP3-only virus-like particles of Adeno-associated virus 2 in E coli cells

Authors: Chengyu Fu, Shruthi Gobbooru, Ashley T Martino, Woon-Kai Low

Journal: Protein Expr Purif

PubMed ID: 38754753

Doi: 10.1016/j.pep.2024.106502

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Scanning mutagenesis of the voltage-gated sodium channel Na12 using base editing

Authors: Juan Lorenzo B Pablo, Savannah L Cornett, Lei A Wang, Sooyeon Jo, Tobias Brünger, Nikita Budnik, Mudra Hegde, Jean-Marc DeKeyser, Christopher H Thompson, John G Doench, Dennis Lal, Alfred L George, Jen Q Pan

Journal: Cell Rep

PubMed ID: 38823014

Doi: 10.1016/j.celrep.2024.114327

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Automated characterization and analysis of expression compatibility between regulatory sequences and metabolic genes in

Authors: Xiao Wen, Jiawei Lin, Chunhe Yang, Ying Li, Haijiao Cheng, Ye Liu, Yue Zhang, Hongwu Ma, Yufeng Mao, Xiaoping Liao, Meng Wang

Journal: Synth Syst Biotechnol

PubMed ID: 38817827

Doi: 10.1016/j.synbio.2024.05.010

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The pioneer transcription factor Zelda facilitates the exit from regeneration and restoration of patterning in

Authors: Anish Bose, Keaton Schuster, Chandril Kodali, Surabhi Sonam, Rachel Smith-Bolton

Journal: biorxiv

PubMed ID: 38854062

Doi: 10.1101/2024.05.30.596672

Products & Services: Proteins, Expression, Isolation and Analysis

Optimization of quenched fluorescent peptide substrates of SARS-CoV-2 3CL main protease (Mpro) from proteomic identification of P6-P6' active site specificity

Authors: Hugo Cesar Ramos de Jesus, Nestor Solis, Yoan Machado, Isabel Pablos, Peter A Bell, Reinhild Kappelhoff, Peter M Grin, Carlos A Sorgi, Georgina S Butler, Christopher M Overall

Journal: J Virol

PubMed ID: 38742901

Doi: 10.1128/jvi.00049-24

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How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism

Authors: David Eisenberg, Ke Hou, Peng Ge, Michael Sawaya, Joshua Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli Feigon

Journal: Res Sq

PubMed ID: 38766197

Doi: 10.21203/rs.3.rs-4152095/v1

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A vector system for single and tandem expression of cloned genes and multi-colour fluorescent tagging in

Authors: Solenne Ithurbide, Roshali T de Silva, Hannah J Brown, Vinaya Shinde, Iain G Duggin

Journal: Microbiology (Reading)

PubMed ID: 38787390

Doi: 10.1099/mic.0.001461

Products & Services: Proteins, Expression, Isolation and Analysis

Plasmodium falciparum Glutamic Acid-Rich Protein-Independent Polyclonal Antibodies Inhibit Malaria Parasite Growth in Human Erythrocytes

Authors: Christopher J Schwake, Rachel M Krueger, Toshihiko Hanada, Athar H Chishti

Journal: J Infect Dis

PubMed ID: 38298126

Doi: 10.1093/infdis/jiae050

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mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models

Authors: Xuesong Wang, Christopher A Cottrell, Xiaozhen Hu, Rashmi Ray, Maria Bottermann, Paula Maldonado Villavicencio, Yu Yan, Zhenfei Xie, John E Warner, Jordan Renae Ellis-Pugh, Oleksandr Kalyuzhniy, Alessia Liguori, Jordan R Willis, Sergey Menis, Sebastian Rämisch, Saman Eskandarzade, Michael Kubitz, Ryan Tingle Nicole Phelps, Bettina Groschel, Sunny Himansu, Andrea Carfi, Kathrin H Kirsch, Stephanie R Weldon, Usha Nair, William R Schief, Facundo D Batista

Journal: Science immunology

PubMed ID: 38753808

Doi: 10.1126/sciimmunol.adn0622

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Single-molecule assay guided crRNA optimization enhances specific microRNA detection by CRISPR-Cas12a

Authors: Kaizhao Chen, Wenjun Sun, Mingtian Zhong, Jiaqi Xie, Yongkun Huo, Xiuqi Lu, Ziting Chen, Bo Sun, Xingxu Huang, Xinjie Wang， Ming Liu , Xiaodong Ma, Peixiang Ma

Journal: Sensors and Actuators B: Chemical

Doi: 10.1016/j.snb.2024.135389

Products & Services: Proteins, Expression, Isolation and Analysis

A Customized Biohybrid presenting Cascade Responses to Tumor Microenvironment

Authors: Feiyu Li, Peipei Zhu, Bingzhu Zheng, Zijie Lu, Chao Fang, Yike Fu, Xiang Li

Journal: Adv Mater

PubMed ID: 38723206

Doi: 10.1002/adma.202404901

Products & Services: Molecular Biology Reagents

Thalidomide derivatives degrade BCL-2 by reprogramming the binding surface of CRBN

Authors: Jianhui Wang (王建辉) , Marcel Heinz, Kang Han (韩康), Varun J. Shah, Sebastian Hasselbeck, Martin P. Schwalm, Rajeshwari Rathore, Gerhard Hummer, Jun Zhou (周俊), Ivan Dikic, Xinlai Cheng (承辛来)

Journal: Cell Reports Physical Science

Doi: doi.org/10.1016/j.xcrp.2024.101960

Products & Services: Molecular Biology Reagents

C9orf72-Associated Dipeptide Repeat Expansions Perturb ER-Golgi Vesicular Trafficking, Inducing Golgi Fragmentation and ER Stress, in ALS/FTD

Authors: Jessica Sultana, Audrey M G Ragagnin, Sonam Parakh, Sayanthooran Saravanabavan, Kai Ying Soo, Marta Vidal, Cyril Jones Jagaraj, Kunjie Ding, Sharlynn Wu, Sina Shadfar, Emily K Don, Anand Deva, Garth Nicholson, Dominic B Rowe, Ian Blair, Shu Yang, Julie D Atkin

Journal: Mol Neurobiol

PubMed ID: 38722513

Doi: 10.1007/s12035-024-04187-4

Products & Services: PCR Cloning and Subcloning

Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools Monitoring Targeted Protein Degradation

Authors: Hanfeng Lin, Kristin Riching, May Poh Lai, Dong Lu, Ran Cheng, Xiaoli Qi, Jin Wang

Journal: biorxiv

PubMed ID: 38798562

Doi: 10.1101/2024.05.14.594249

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Two-point immobilization of M3 muscarinic receptor: a method for recognizing receptor antagonists in natural products

Authors: Xiaomin Huang, Ting Wang, Ludan Wang, Yantao Sun, Ziru Zhang, Yajun Zhang

Journal: BMC Chem

PubMed ID: 38702791

Doi: 10.1186/s13065-024-01198-z

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for Deciphering Selenium-Encoded Peptide and a Pyrolysis-Thermolysis Dietary Model for Minimizing Loss of "KKSe(M)R" during Processing

Authors: Xin Wang, Wei Jia

Journal: J Agric Food Chem

PubMed ID: 38770928

Doi: 10.1021/acs.jafc.4c01638

Products & Services: Catalog Peptides

Cloning and functional characterization of novel human neutralizing anti-interferon-alpha and anti-interferon-beta antibodies

Authors: Emmanouil Papasavvas, Lily Lu, Matthew Fair, Isabela Oliva, Joel Cassel, Sonali Majumdar, Karam Mounzer, Jay R Kostman, Pablo Tebas, Amit Bar-Or, Kar Muthumani, Luis J Montaner

Journal: biorxiv

PubMed ID: 38746170

Doi: 10.1101/2024.05.05.591636

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Na,K-ATPase activity promotes macropinocytosis in colon cancer via Wnt signaling

Authors: Nydia Tejeda-Muñoz, Yagmur Azbazdar, Eric A Sosa, Julia Monka, Pu-Sheng Wei, Grace Binder, Kuo-Ching Mei, Yerbol Z Kurmangaliyev, Edward M De Robertis

Journal: Biol Open

PubMed ID: 38713004

Doi: 10.1242/bio.060269

Products & Services: PCR Cloning and Subcloning

E3 ubiquitin ligase RNF2 protects polymerase ι from destabilization

Authors: Mikolaj Fedorowicz, Agnieszka Halas, Matylda Macias, Ewa Sledziewska-Gojska, Roger Woodgate, Justyna McIntyre

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 38705361

Doi: 10.1016/j.bbamcr.2024.119743

Products & Services: Molecular Biology Reagents

Disulfidptosis in head and neck squamous carcinoma: Integrative bioinformatic and in-vitro analysis

Authors: Xufeng Huang, Jinyan Yang, Qi Wang, Rao Fu, Xutao Wen, Zhengrui Li, Ling Zhang

Journal: Oral Dis

PubMed ID: 38696646

Doi: 10.1111/odi.14977

Products & Services: Molecular Biology Reagents

A PACAP-activated network for secretion requires coordination of Ca influx and Ca mobilization

Authors: Xiaohuan Chen, Nicole A Bell, Breanna L Coffman, Agustin A Rabino, Rafael Garcia-Mata, Paul J Kammermeier, David I Yule, Daniel Axelrod, Alan V Smrcka, David R Giovannucci, Arun Anantharam

Journal: Mol Biol Cell

PubMed ID: 38758660

Doi: 10.1091/mbc.E24-02-0083

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Polyglutamine-mediated ribotoxicity disrupts proteostasis and stress responses in Huntington's disease

Authors: Ranen Aviner, Ting-Ting Lee, Vincent B Masto, Kathy H Li, Raul Andino, Judith Frydman

Journal: Nat Cell Biol

PubMed ID: 38741019

Doi: 10.1038/s41556-024-01414-x

Products & Services: ORF cDNA Clones/MolecularCloud

Arg-biodynamers as antibiotic potentiators through interacting with Gram-negative outer membrane lipopolysaccharides

Authors: Mohamed A M Kamal, Justine Bassil, Brigitta Loretz, Anna K H Hirsch, Sangeun Lee, Claus-Michael Lehr

Journal: Eur J Pharm Biopharm

PubMed ID: 38795784

Doi: 10.1016/j.ejpb.2024.114336

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Novel enzymes for biodegradation of polycyclic aromatic hydrocarbons identified by metagenomics and functional analysis in short-term soil microcosm experiments

Authors: Kinga K Nagy, Kristóf Takács, Imre Németh, Bálint Varga, Vince Grolmusz, Mónika Molnár, Beáta G Vértessy

Journal: Sci Rep

PubMed ID: 38773163

Doi: 10.1038/s41598-024-61566-6

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Nonspecific phospholipases C3 and C4 interact with PIN-FORMED2 to regulate growth and tropic responses in Arabidopsis

Authors: Teng Li, Shujuan Zhang, Shuaibing Yao, Xuebing Li, Qianru Jia, Jingya Yuan, Wenhua Zhang, Xuemin Wang, Qun Zhang

Journal: Plant Cell

PubMed ID: 38442314

Doi: 10.1093/plcell/koae071

Products & Services: Proteins, Expression, Isolation and Analysis

Structural characterization of E22G Aβ fibrils H detected MAS NMR

Authors: Natalie C Golota, Brian Michael, Edward P Saliba, Sara Linse, Robert G Griffin

Journal: Phys Chem Chem Phys

PubMed ID: 38715538

Doi: 10.1039/d4cp00553h

Products & Services: Molecular Biology Reagents

Cysteine, sodium metabisulfite, and glutathione enhance crosslinking between proteins during high moisture meat analog extrusion processing and may improve the fibrousness of the products

Authors: Jana K Richter, Preston Watanabe, Josh Bernin, Brennan Smith, Rachel Mitacek, Girish M Ganjyal

Journal: J Sci Food Agric

PubMed ID: 38804791

Doi: 10.1002/jsfa.13569

Products & Services: Proteins, Expression, Isolation and Analysis

Nanobody-based immunosensor for the detection of H pylori in saliva

Authors: Mohammad Ia Ahmad, Célia G Amorim, Luay F Abu Qatouseh, Maria C B S M Montenegro

Journal: Biosens Bioelectron

PubMed ID: 38810413

Doi: 10.1016/j.bios.2024.116423

Products & Services: Gene Synthesis

Deletion of Asb15b gene can lead to a significant decrease in zebrafish intermuscular bone

Authors: Minghui Niu, Huamin Whang, Zhichao Wu, Shouwen Jiang, Liangbiao Chen

Journal: Gene

PubMed ID: 38754570

Doi: 10.1016/j.gene.2024.148561

CYP116B5-SOX: An artificial peroxygenase for drug metabolites production and bioremediation

Authors: Daniele Giuriato, Gianluca Catucci, Danilo Correddu, Giovanna Di Nardo, Gianfranco Gilardi

Journal: Biotechnol J

PubMed ID: 38719620

Doi: 10.1002/biot.202300664

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Cellular metabolism of substance P produces neurokinin-1 receptor peptide agonists with diminished cyclic AMP signaling

Authors: Tamas Kriska, Jayashree Natarajan, Anja Herrnreiter, Sang-Kyu Park, Sandra L Pfister, Michael J Thomas, Alexander Widiapradja, Scott P Levick, William B Campbell

Journal: Am J Physiol Cell Physiol

PubMed ID: 38798270

Doi: 10.1152/ajpcell.00103.2024

Products & Services: Molecular Biology Reagents

Single-shot dendritic cell targeting SARS-CoV-2 vaccine candidate induces broad, durable and protective systemic and mucosal immunity in mice

Authors: Nicholas You Zhi Cheang, Kai Sen Tan, Peck Szee Tan, Kiren Purushotorma, Wee Chee Yap, Kirsteen McInnes Tullett, Benson Yen Leong Chua, Aileen Ying-Yan Yeoh, Caris Qi Hui Tan, Xinlei Qian, Huixin Chen, Douglas Jie Wen Tay, Irina Caminschi, Yee Joo Tan, Paul Anthony Macary, Chee Wah Tan, Mireille Hanna Lahoud, Sylvie Alonso

Journal: Mol Ther

PubMed ID: 38715364

Doi: 10.1016/j.ymthe.2024.05.003

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Nanoemulsions and nanocapsules as carriers for the development of intranasal mRNA vaccines

Authors: Mireya L Borrajo, Gustavo Lou, Shubaash Anthiya, Philipp Lapuhs, David Moreira Álvarez, Araceli Tobío, María Isabel Loza, Anxo Vidal, María José Alonso

Journal: Drug Deliv Transl Res

PubMed ID: 38811465

Doi: 10.1007/s13346-024-01635-5

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An integrated multi-omics approach reveals polymethoxylated flavonoid biosynthesis in Citrus reticulata cv Chachiensis

Authors: Jiawen Wen, Yayu Wang, Xu Lu, Huimin Pan, Dian Jin, Jialing Wen, Canzhi Jin, Sunil Kumar Sahu, Jianmu Su, Xinyue Luo, Xiaohuan Jin, Jiao Zhao, Hong Wu, E-Hu Liu, Huan Liu

Journal: Nat Commun

PubMed ID: 38734724

Doi: 10.1038/s41467-024-48235-y

Products & Services: Recombinant Proteins

Early Animal Origin of BACE1 APP/Aβ Proteolytic Function

Authors: James A Langeland, Lillian Baumann, Eva M DeYoung, Raphaela Angelina Varella, Nkatha Mwenda, Alejandro Aguirre, D Blaine Moore

Journal: Biology (Basel)

PubMed ID: 38785802

Doi: 10.3390/biology13050320

Products & Services: Gene Synthesis

Three in one: An effective and universal vaccine expressing heterologous tandem RBD trimer by rabies virus vector protects mice against SARS-CoV-2

Authors: Jingbo Huang, Weiqi Wang, Hailun Li, Yujie Bai, Yumeng Song, Cuicui Jiao, Hongli Jin, Pei Huang, Haili Zhang, Xianzhu Xia, Feihu Yan, Yuanyuan Li, Hualei Wang

Journal: Antiviral Res

PubMed ID: 38740191

Doi: 10.1016/j.antiviral.2024.105905

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Generation and evaluation of cancer binding capacity of HLA-A2-WT1 complex-targeting antibody

Authors: Xue Yao, Sandro Matosevic

Journal: Immunol Lett

PubMed ID: 38810886

Doi: 10.1016/j.imlet.2024.106881

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Transcriptome dynamics of the BHK21 cell line in response to human coronavirus OC43 infection

Authors: Mianhuan Li, Yang Yang, Pusen Wang, Weitao Que, Lin Zhong, Zhao Cai, Yang Liu, Liang Yang, Yingxia Liu

Journal: Microbiol Res

PubMed ID: 38761489

Doi: 10.1016/j.micres.2024.127750

Products & Services: Proteins, Expression, Isolation and Analysis

TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer

Authors: Yanting Lin, Rui Gao, Dongquan Jing, Yiming Liu, Huijuan Da, Lutz Birnbaumer, Yong Yang, Xinghua Gao, Zhenhua Gao, Qiuhua Cao

Journal: Front Pharmacol

PubMed ID: 38835669

Doi: 10.3389/fphar.2024.1392328

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Crystal structure of human peptidylarginine deiminase type VI (PAD6) provides insights into its inactivity

Authors: Fanomezana M Ranaivoson, Rieke Bande, Isabell Cardaun, Antonio De Riso, Annette Gärtner, Pui Loke, Christina Reinisch, Prasuna Vogirala, Edward Beaumont

Journal: IUCrJ

PubMed ID: 38656308

Doi: 10.1107/S2052252524002549

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CXCR3 participates in asymmetric division of mouse oocytes by modulating actin dynamics

Authors: Wei-Jian Li, Rong-Yang Li, Da-Yu Wang, Ming Shen, Hong-Lin Liu

Journal: Theriogenology

PubMed ID: 38788628

Doi: 10.1016/j.theriogenology.2024.05.028

Products & Services: Proteins, Expression, Isolation and Analysis

Intranasal Vaccination with a Respiratory-Syncytial-Virus-Based Virus-like Particle Displaying the G Protein Conserved Region Induces Severe Weight Loss and Pathology upon Challenge with Wildtype Respiratory Syncytial Virus

Authors: Megolhubino Terhüja, Manjunath Siddappa, Pramila Lamichhane, Chetan D Meshram, Timothy A Snider, Jerry W Ritchey, Antonius G P Oomens

Journal: Viruses

PubMed ID: 38932136

Doi: 10.3390/v16060843

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Modified Zhenwu Tang delays chronic renal failure progression by modulating oxidative stress and hypoxic responses in renal proximal tubular epithelial cells

Authors: Yuan-Yuan Zhang, Pei-Pei Jin, Deng-Zhou Guo, Dong Bian

Journal: Heliyon

PubMed ID: 38803876

Doi: 10.1016/j.heliyon.2024.e31265

Products & Services: Proteins, Expression, Isolation and Analysis

Systemic LPS Administration Stimulates the Activation of Non-Neuronal Cells in an Experimental Model of Spinal Muscular Atrophy

Authors: Eleni Karafoulidou, Evangelia Kesidou, Paschalis Theotokis, Chrystalla Konstantinou, Maria-Konstantina Nella, Iliana Michailidou, Olga Touloumi, Eleni Polyzoidou, Ilias Salamotas, Ofira Einstein, Athanasios Chatzisotiriou, Marina-Kleopatra Boziki, Nikolaos Grigoriadis

Journal: Cells

PubMed ID: 38727321

Doi: 10.3390/cells13090785

Products & Services: Proteins, Expression, Isolation and Analysis

Investigating the Antimicrobial Effects of a Novel Peptide Derived From Listeriolysin S on , and : An In Silico and In Vitro Study

Authors: Mojgan Sarabi Nobakht, Kaveh Bazyar, Mohammad Sadegh Ghalyanchi Langeroudi, Mandana Mirzaei, Mehdi Goudarzi, Ali Shivaee

Journal: Bioinform Biol Insights

PubMed ID: 38765021

Doi: 10.1177/11779322241252513

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SARS-CoV-2 Surveillance of Wild Mice and Rats in North American Cities

Authors: Lisa K F Lee, Chelsea G Himsworth, Natalie Prystajecky, Antonia Dibernardo, L Robbin Lindsay, Theresa M Albers, Rajeev Dhawan, Ken Henderson, Guy Mulder, Harveen K Atwal, Imara Beattie, Bruce K Wobeser, Michael H Parsons, Kaylee A Byers

Journal: Ecohealth

PubMed ID: 38748281

Doi: 10.1007/s10393-024-01679-6

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Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes

Authors: Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Zhiya Yu, Sivasish Sindiri, Jared J Gartner, Maria Parkhurst, Sri Krishna, Frank J Lowery, Nikolaos Zacharakis, Lior Levy, Todd D Prickett, Tiffany Benzine, Satyajit Ray, Robert V Masi, Billel Gasmi, Yong Li, Rafiqul Islam, Alakesh Bera, Stephanie L Goff, Paul F Robbins, Steven A Rosenberg

Journal: J Immunother Cancer

PubMed ID: 38816232

Doi: 10.1136/jitc-2023-008645

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Application of MALDI-MS for characterization of fucoidan hydrolysates and screening of endo-fucoidanase activity

Authors: Diego S Reyes-Weiss, Margot Bligh, Nanna Rhein-Knudsen, Jan-Hendrik Hehemann, Manuel Liebeke, Bjørge Westereng, Svein Jarle Horn

Journal: Carbohydr Polym

PubMed ID: 38858030

Doi: 10.1016/j.carbpol.2024.122317

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