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but not is the avirulence determinant in melon carrying the resistance against watermelon mosaic virus, although they contain a common genetic determinant

Authors: Zhen Sun, Yu-Xuan Wu, Ling-Zhi Liu, Yan-Ping Tian, Xiang-Dong Li, Chao Geng

Journal: J Virol

PubMed ID: 38775482

Doi: 10.1128/jvi.00507-24

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis of human mpox viral DNA replication inhibition by brincidofovir and cidofovir

Authors: Yunxia Xu, Yaqi Wu, Xiaoying Wu, Yuanyuan Zhang, Yaxue Yang, Danyang Li, Biao Yang, Kaiting Gao, Zhengyu Zhang, Changjiang Dong

Journal: Int J Biol Macromol

PubMed ID: 38735603

Doi: 10.1016/j.ijbiomac.2024.132231

Products & Services: Proteins, Expression, Isolation and Analysis

Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study

Authors: Tomas O Jensen, Thomas A Murray, Greg A Grandits, Mamta K Jain, Birgit Grund, Kathryn Shaw-Saliba, Michael A Matthay, Mahsa Abassi, Magdalena Ardelt, Jason V Baker, Peter Chen, Robin L Dewar, Anna L Goodman, Timothy J Hatlen, Helene C Highbarger, Mark Holodniy, Perrine Lallemand, Sylvain Laverdure, Bradley G Leshnower, David Looney, Charalampos D Moschopoulos, Henry Mugerwa, Daniel D Murray, Eleftherios Mylonakis, Stephanie Nagy-Agren, M Tauseef Rehman, Adam Rupert, Randy Stevens, Stuart Turville, Amy Weintrob, Katherine Wick, Jens Lundgren, Emily R Ko

Journal: Lancet Microbe

PubMed ID: 38815595

Doi: 10.1016/S2666-5247(24)00015-6

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Nanolevel of detection of ascorbic acid using horse-radish peroxidase inhibition assay

Authors: Bijon Kumar Sil, Mohd Raeed Jamiruddin, Md Ahsanul Haq, Nattanit Aekwattanaphol, Prem Ananth K, Limbadri Salendra, Himanshu Paliwal, Pijush Kumar Paul, Wilaiporn Buatong, Teerapol Srichana

Journal: Heliyon

PubMed ID: 38774337

Doi: 10.1016/j.heliyon.2024.e30715

Products & Services: Proteins, Expression, Isolation and Analysis

Podocyte Pathogenic Bone Morphogenetic Protein-2 Pathway and Immune Cell Behaviors in Primary Membranous Nephropathy

Authors: Anxiang Cai, Yiwei Meng, Hang Zhou, Hong Cai, Xinghua Shao, Qin Wang, Yao Xu, Yin Zhou, Wenyan Zhou, Luonan Chen, Shan Mou

Journal: Adv Sci (Weinh)

PubMed ID: 38785168

Doi: 10.1002/advs.202404151

Products & Services: Proteins, Expression, Isolation and Analysis

LncRNA CCRR maintains Ca homeostasis against myocardial infarction through the FTO-SERCA2a pathway

Authors: Hua Yang, Lina Xuan, Shengjie Wang, Huishan Luo, Xiaomeng Duan, Jianjun Guo, Shijia Cui, Jieru Xin, Junwei Hao, Xiufang Li, Jun Chen, Feihan Sun, Xiaolin Hu, Siyun Li, Ying Zhang, Lei Jiao, Baofeng Yang, Lihua Sun

Journal: Sci China Life Sci

PubMed ID: 38761356

Doi: 10.1007/s11427-023-2527-5

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Functional characterization of a novel flavin reductase from a deep-sea sediment metagenomic library and its application for indirubin production

Authors: Jikun Du, Yuanhua Li, Zhengzhuang Chen, Chang Wang, Yali Huang, Li Li

Journal: Appl Environ Microbiol

PubMed ID: 38780258

Doi: 10.1128/aem.00429-24

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and analysis reveal impact of c-Myc tag in FMC63 scFv-CD19 protein interface and CAR-T cell efficacy

Authors: Ana Julia Ferreira Lima, Karina Lobo Hajdu, Luiza Abdo, Leonardo Ribeiro Batista-Silva, Clara de Oliveira Andrade, Eduardo Mannarino Correia, Emmanuel Arthur Albuquerque Aragão, Martín Hernán Bonamino, Marcos Roberto Lourenzoni

Journal: Comput Struct Biotechnol J

PubMed ID: 38873646

Doi: 10.1016/j.csbj.2024.05.032

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CircRNA SEC24A promotes osteoarthritis through miR-107-5p/CASP3 axis

Authors: Tuerxunjiang Dadihanc, Yong Zhang, Guo-Qing Li, Hai-Kang Zhou, Jingyong Huang, Xue Zhang, Zhi-Qiang Li, Hai-Rong Ma

Journal: Regen Ther

PubMed ID: 38828010

Doi: 10.1016/j.reth.2024.04.011

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One-pot sustainable synthesis of glucosylglycerate from starch and glycerol through artificial in vitro enzymatic cascade

Authors: Juanjuan Liu, Mengfei Ren, Haoran Ma, Huilin Zhang, Xinyu Cui, Runyuan Kang, Xinming Feng, Dongdong Meng

Journal: Bioresour Technol

PubMed ID: 38508282

Doi: 10.1016/j.biortech.2024.130611

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Wheat peptide alleviates DSS-induced colitis by activating the Keap1-Nrf2 signaling pathway and maintaining the integrity of the gut barrier

Authors: Wen-Yin Xie, Zhong-Hao Ji, Wen-Zhi Ren, Pei-Sen Zhao, Fan-Hao Wei, JinPing Hu, Bao Yuan, Wei Gao

Journal: Food Funct .

PubMed ID: 38690672

Doi: 10.1039/d3fo04413k.

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The MuSK agonist antibody protects the neuromuscular junction and extends the lifespan in C9orf72-ALS mice

Authors: Shuangshuang Sun, Yihui Shen, Xu Zhang, Ning Ding, Zhe Xu, Qijie Zhang, Lei Li

Journal: Mol Ther

PubMed ID: 38734896

Doi: 10.1016/j.ymthe.2024.05.016

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Characterisation of novel influenza-derived HLA-B*18:01-restricted epitopes

Authors: Samuel Liwei Leong, Lawton Murdolo, Janesha C Maddumage, Marios Koutsakos, Katherine Kedzierska, Anthony W Purcell, Stephanie Gras, Emma J Grant

Journal: Clin Transl Immunology

PubMed ID: 38737448

Doi: 10.1002/cti2.1509

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A fluorescently-tagged tick kinin neuropeptide triggers peristalsis and labels tick midgut muscles

Authors: Jonathan R Hernandez, Caixing Xiong, Patricia V Pietrantonio

Journal: Sci Rep

PubMed ID: 38740831

Doi: 10.1038/s41598-024-61570-w

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Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation

Authors: Kaidi Chen, Seongmin Ha, Leyao Xu, Chengwu Liu, Yuanxiang Liu, Xiayi Wu, Zhipeng Li, Shiyu Wu, Bo Yang, Zhuofan Chen

Journal: J Transl Med

PubMed ID: 38720345

Doi: 10.1186/s12967-024-05261-0

Products & Services: Proteins, Expression, Isolation and Analysis

Evolution of a novel adrenal cell type that promotes parental care

Authors: Natalie Niepoth, Jennifer R Merritt, Michelle Uminski, Emily Lei, Victoria S Esquibies, Ina B Bando, Kimberly Hernandez, Christoph Gebhardt, Sarah A Wacker, Stefano Lutzu, Asmita Poudel, Kiran K Soma, Stephanie Rudolph, Andres Bendesky

Journal: Nature

PubMed ID: 38750354

Doi: 10.1038/s41586-024-07423-y

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Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Authors: Nishant Mohan, Safiat Ayinde, Hanjing Peng, Shraboni Dutta, Yi Shen, Vincent M Falkowski, Thomas G Biel, Tongzhong Ju, Wen Jin Wu

Journal: Front Immunol

PubMed ID: 38863707

Doi: 10.3389/fimmu.2024.1376096

Products & Services: Proteins, Expression, Isolation and Analysis

Context dependent activity of p63-bound gene regulatory elements

Authors: Abby A McCann, Gabriele Baniulyte, Dana L Woodstock, Morgan A Sammons

Journal: biorxiv

PubMed ID: 38766006

Doi: 10.1101/2024.05.09.593326

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Functional Application of the Single-Module NRPS-like D-Alanyltransferase in Maytansinol Biosynthesis

Authors: Zhongyue Li, Zhonghang Zhu, Guangsen Xu, Lin Wei, Jiang Liu, Haoxin Wang, Chunhua Lu, Yaoyao Li, Deyu Zhu*, and Yuemao Shen

Journal: ACS Catal

Doi: 10.1021/acscatal.4c00082

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Fibroblast growth factor 21 enhances learning and memory performance in mice by regulating hippocampal L-lactate homeostasis

Authors: Jiaojiao Xie, Jiapin Yan, Keru Ji, Yuejun Guo, Sibei Xu, Danjie Shen, Chen Li, Hongchang Gao, Liangcai Zhao

Journal: Int J Biol Macromol

PubMed ID: 38801850

Doi: 10.1016/j.ijbiomac.2024.132667

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Fungicidal Activity of New Pyrrolo[2,3-]thiazoles and Their Potential Action on the Tryptophan Metabolic Pathway and Wax Biosynthesis

Authors: Yue Zhang, Jing Li, Hongwei Yang, Kun Li, Haolin Yuan, Ziqiao Xue, Liangfu Tang, Zhijin Fan

Journal: J Agric Food Chem

PubMed ID: 38757490

Doi: 10.1021/acs.jafc.4c00930

Products & Services: DNA Sequencing

Earliest records of the Asian longhorned tick (Acari: Ixodidae) in Staten Island, New York, and subsequent population establishment, with a review of its potential medical and veterinary importance in the United States

Authors: Waheed Bajwa, Ashley Kennedy, Zachary Vincent, Garrett Heck, Shamim Riaj, Zahir Shah, Leonid Tsynman, Cory Casal, Scott Haynes, Hannah Cornman, Andrea Egizi, Ellen Stromdahl, Robyn Nadolny

Journal: J Med Entomol

PubMed ID: 38412407

Doi: 10.1093/jme/tjae019

Products & Services: Proteins, Expression, Isolation and Analysis

Nonclinical Evaluation of Single-Mutant Asparaginases Obtained by Double-Mutant Deconvolution: Improving Toxicological, Immune and Inflammatory Responses

Authors: Grace Ruiz-Lara, Tales A Costa-Silva, Jorge Javier Muso-Cachumba, Johanna Cevallos Espinel, Marina Gabriel Fontes, Mitla Garcia-Maya, Khondaker Miraz Rahman, Carlota de Oliveira Rangel-Yagui, Gisele Monteiro

Journal: Int J Mol Sci

PubMed ID: 38892196

Doi: 10.3390/ijms25116008

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Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1

Authors: Kyle Scranton, Scott John, Marina Angelini, Federica Steccanella, Soban Umar, Rui Zhang, Joshua I Goldhaber, Riccardo Olcese, Michela Ottolia

Journal: Nat Commun

PubMed ID: 38714663

Doi: 10.1038/s41467-024-47850-z

Products & Services: Proteins, Expression, Isolation and Analysis

Conditional knockdown of OsMLH1 to improve plant prime editing systems without disturbing fertility in rice

Authors: Xiaoshuang Liu, Dongfang Gu, Yiru Zhang, Yingli Jiang, Zhi Xiao, Rongfang Xu, Ruiying Qin, Juan Li, Pengcheng Wei

Journal: Genome Biol

PubMed ID: 38773623

Doi: 10.1186/s13059-024-03282-y

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Legionella maintains host cell ubiquitin homeostasis by effectors with unique catalytic mechanisms

Authors: Jiaqi Fu, Siying Li, Hongxin Guan, Chuang Li, Tao-Tao Chen, Wei Xian, Zhengrui Zhang, Yao Liu, Qingtian Guan, Jingting Wang, Qiuhua Lu, Lina Kang, Si-Ru Zheng, Jinyu Li, Shoujing Cao, Chittaranjan Das, Xiaoyun Liu, Lei Song, Songying Ouyang, Zhao-Qing Luo

Journal: Res Sq

PubMed ID: 38826349

Doi: 10.21203/rs.3.rs-4431542/v1

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Hybrid Cas12a Variants with Relaxed PAM Requirements Expand Genome Editing Compatibility

Authors: Zhenyu Liu, Huayi Liu, Chaoqun Huang, Qun Zhou, Yunzi Luo

Journal: ACS Synth Biol

PubMed ID: 38819403

Doi: 10.1021/acssynbio.4c00103

Products & Services: Proteins, Expression, Isolation and Analysis

A "One-Step" Strategy for the Global Characterization of Core-Fucosylated Glycoproteome

Authors: Yuqiu Wang, Rui Yuan, Bo Liang, Jing Zhang, Qin Wen, Hongxu Chen, Yinping Tian, Liuqing Wen, Hu Zhou

Journal: JACS Au

PubMed ID: 38818065

Doi: 10.1021/jacsau.4c00214

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Characterization of Esterase Capable of Hydrolyzing Bis(2-hydroxyethyl) Terephthalate

Authors: Sizhong Feng, Mengke Xue, Fang Xie, Hongyang Zhao, Yemin Xue

Journal: J Agric Food Chem

PubMed ID: 38753963

Doi: 10.1021/acs.jafc.4c01973

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Functional characterization of the InR/PI3K/AKT signaling pathway in female reproduction of the predatory bug Cyrtorhinus lividipennis (Hemiptera: Miridae)

Authors: Kui Hu, Rong Jin, Jianqi Liu, Jun Zhu, Wei Dai, Ying Wang, Yao Li, Fang Liu

Journal: J Econ Entomol

PubMed ID: 38783398

Doi: 10.1093/jee/toae113

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Alpha and gamma mangostins inhibit wild-type B SARS-CoV-2 more effectively than the SARS-CoV-2 variants and the major target is unlikely the 3C-like protease

Authors: Aphinya Suroengrit, Van Cao, Patcharin Wilasluck, Peerapon Deetanya, Kittikhun Wangkanont, Kowit Hengphasatporn, Ryuhei Harada, Supakarn Chamni, Asada Leelahavanichkul, Yasuteru Shigeta, Thanyada Rungrotmongkol, Supot Hannongbua, Warinthorn Chavasiri, Supaporn Wacharapluesadee, Eakachai Prompetchara, Siwaporn Boonyasuppayakorn

Journal: Heliyon

PubMed ID: 38867992

Doi: 10.1016/j.heliyon.2024.e31987

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Virus-like particle-based multipathogen vaccine of FMD and SVA elicits balanced and broad protective efficacy in mice and pigs

Authors: Hetao Song, Sahibzada Waheed Abdullah, Shuanghui Yin, Hu Dong, Yun Zhang, Shuzhen Tan, Manyuan Bai, Yaozhong Ding, Zhidong Teng, Shiqi Sun, Huichen Guo

Journal: Vaccine

PubMed ID: 38714448

Doi: 10.1016/j.vaccine.2024.04.092

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POLR2J expression promotes glioblastoma malignancy by regulating oxidative stress and the STAT3 signaling pathway

Authors: Xiao-Li Zheng, Zhi-Di Li, Kai-Zhi Luo, Yang-Ling Li, Ye-Han Liu, Shu-Ying Shen, Fei-Yan Shen, Wan-Yan Li, Guo-Qing Chen, Chong Zhang, Ling-Hui Zeng

Journal: Am J Cancer Res

PubMed ID: 38859843

Doi: 10.62347/JEWM7691

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Discrimination of Aspartic and Isoaspartic Acid Residues in Peptides by Tandem Mass Spectrometry with Hydrogen Attachment Dissociation

Authors: Daiki Asakawa, Shinich Iwamoto, Koichi Tanaka

Journal: Anal Chem

PubMed ID: 38741470

Doi: 10.1021/acs.analchem.4c00561

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SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses

Authors: Ze-Zheng Jiang, Min Chu, Li-Na Yan, Wen-Kang Zhang, Bang Li, Jiao Xu, Zhong-Xin Zhao, Hui-Ju Han, Chuan-Min Zhou, Xue-Jie Yu

Journal: Microbiol Spectr

PubMed ID: 38712963

Doi: 10.1128/spectrum.03796-23

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MiR-30a-5p isoform -1|1 promotes the progression of gastric cancer by inhibiting TMEM66 and reducing intratumoral cytotoxic T cells

Authors: Yanmiao Dai, Yudong Xu, Jie Shen, Caihong Hu, Xiaoli Li, Yongyu Chen, Yao Liu, Duanmin Hu

Journal: Exp Cell Res

PubMed ID: 38802035

Doi: 10.1016/j.yexcr.2024.114099

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Kinetic Characterization and Identification of Key Active Site Residues of the L-Aspartate N-Hydroxylase, CreE

Authors: Sydney B Johnson, Hannah Valentino, Pablo Sobrado

Journal: Chembiochem

PubMed ID: 38775737

Doi: 10.1002/cbic.202400350

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Structural Determinants of FeoB Nucleotide Promiscuity

Authors: Mark Lee, Kate Magante, Camilo Gómez-Garzón, Shelley M Payne, Aaron T Smith

Journal: biorxiv

PubMed ID: 38826458

Doi: 10.1101/2024.05.22.595361

Products & Services: Proteins, Expression, Isolation and Analysis

SUMOylated Golgin45 associates with PML-NB to transcriptionally regulate lipid metabolism genes during heat shock stress

Authors: Shuaiyang Jing, Jingkai Gao, Neeraj Tiwari, Yulei Du, Lianhui Zhu, Bopil Gim, Yi Qian, Xihua Yue, Intaek Lee

Journal: Commun Biol

PubMed ID: 38710927

Doi: 10.1038/s42003-024-06232-3

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Structural basis of substrate recognition and allosteric activation of the proapoptotic mitochondrial HtrA2 protease

Authors: Emelie E Aspholm, Jens Lidman, Björn M Burmann

Journal: Nat Commun

PubMed ID: 38816423

Doi: 10.1038/s41467-024-48997-5

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A new suite of reporter vectors and a novel landing site survey system to study cis-regulatory elements in diverse insect species

Authors: Kevin D Deem, Marc S Halfon, Yoshinori Tomoyasu

Journal: Sci Rep

PubMed ID: 38698030

Doi: 10.1038/s41598-024-60432-9

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Identification of an Immunodominant B-Cell Epitope in African Swine Fever Virus p30 Protein and Evidence of p30 Antibody-Mediated Antibody Dependent Cellular Cytotoxicity

Authors: Jessica C G Noll, Ruchi Rani, Salman L Butt, Maureen Hoch Vieira Fernandes, Gabriela Mansano do Nascimento, Mathias Martins, Leonardo C Caserta, Lina Covaleda, Diego G Diel

Journal: Viruses

PubMed ID: 38793639

Doi: 10.3390/v16050758

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Intranasal respiratory syncytial virus vaccine attenuated by codon-pair deoptimization of seven open reading frames is genetically stable and elicits mucosal and systemic immunity and protection against challenge virus replication in hamsters

Authors: Megan Levy, Jessica W Chen, Jaclyn A Kaiser, Hong-Su Park, Xueqiao Liu, Lijuan Yang, Celia Santos, Ursula J Buchholz, Cyril Le Nouën

Journal: PLoS Pathog

PubMed ID: 38739647

Doi: 10.1371/journal.ppat.1012198

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Divergent effects of olfactory receptors on transient receptor potential vanilloid 1 activation by capsaicin and eugenol

Authors: Sakura Moriyama, Yukie Takita, Shuji Hinuma, Shun'ichi Kuroda

Journal: Biosci Biotechnol Biochem

PubMed ID: 38734894

Doi: 10.1093/bbb/zbae060

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Staphylococcal peroxidase inhibitor (SPIN): Residue-level investigation of the helical bundle domain

Authors: Soheila Fatehi, Timothy J Herdendorf, Nicoleta T Ploscariu, Brian V Geisbrecht

Journal: Arch Biochem Biophys

PubMed ID: 38705227

Doi: 10.1016/j.abb.2024.110023

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Preparation and epitope analysis of monoclonal antibodies against African swine fever virus DP96R protein

Authors: Chao Li, Xuan-Ying Si, Xiao-Ge Wang, Zhi-Wei Yan, Hao-Yu Hou, Long-Qi You, Yin-Long Chen, Ang-Ke Zhang, Na Wang, Ai-Jun Sun, Yong-Kun Du, Gai-Ping Zhang

Journal: BMC Vet Res

PubMed ID: 38734611

Doi: 10.1186/s12917-024-04043-6

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Engineering and evaluation of FXa bypassing agents that restore hemostasis following Apixaban associated bleeding

Authors: Wojciech Jankowski, Stepan S. Surov, Nancy E. Hernandez, Atul Rawal, Marcos Battistel, Daron Freedberg, Mikhail V. Ovanesov & Zuben E. Sauna

Journal: Nat Commun

PubMed ID: 38724509

Doi: 10.1038/s41467-024-48278-1

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Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity

Authors: Shengjun Wang, Wei Ran, Lingyu Sun, Qingchi Fan, Yuanqi Zhao, Bowen Wang, Jinghong Yang, Yuqi He, Ying Wu, Yuanyuan Wang, Luoyi Chen, Arpaporn Chuchuay, Yuyu You, Xinhai Zhu, Xiaojuan Wang, Ye Chen, Yanqun Wang, Yao-Qing Chen, Yanqiu Yuan, Jincun Zhao & Yang Mao

Journal: Nat Commun

PubMed ID: 38755139

Doi: 10.1038/s41467-024-48503-x

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The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis

Authors: Julia Zibold, Lola E R Lessard, Flavien Picard, Lara Gruijs da Silva, Yelyzaveta Zadorozhna, Nathalie Streichenberger, Edwige Belotti, Alexis Osseni, Andréa Emerit, Elisabeth Errazuriz-Cerda, Laurence Michel-Calemard, Rita Menassa, Laurent Coudert, Manuela Wiessner, Rolf Stucka, Thomas Klopstock, Francesca Simonetti, Saskia Hutten, Takashi Nonaka, Masato Hasegawa, Tim M Strom, Emilien Bernard, Elisabeth Ollagnon, Andoni Urtizberea, Dorothee Dormann, Philippe Petiot, Laurent Schaeffer, Jan Senderek, Pascal Leblanc

Journal: Brain

PubMed ID: 38079474

Doi: 10.1093/brain/awad410

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A nutrient responsive lipase mediates gut-brain communication to regulate insulin secretion in Drosophila

Authors: Alka Singh, Kandahalli Venkataranganayaka Abhilasha, Kathya R. Acharya, Haibo Liu, Niraj K. Nirala, Velayoudame Parthibane, Govind Kunduri, Thiruvaimozhi Abimannan, Jacob Tantalla, Lihua Julie Zhu, Jairaj K. Acharya & Usha R. Acharya

Journal: Nat Commun

PubMed ID: 38782979

Doi: 10.1038/s41467-024-48851-8

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The EV71 2A protease occupies the central cleft of SETD3 and disrupts SETD3-actin interaction

Authors: Xiaopan Gao, Bei Wang, Kaixiang Zhu, Linyue Wang, Bo Qin, Kun Shang, Wei Ding, Jianwei Wang & Sheng Cui

Journal: Nat Commun

PubMed ID: 38755176

Doi: 10.1038/s41467-024-48504-w

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The translocation of a chloride channel from the Golgi to the plasma membrane helps plants adapt to salt stress

Authors: Sivamathini Rajappa, Pannaga Krishnamurthy, Hua Huang, Dejie Yu, Jiří Friml, Jian Xu & Prakash P. Kumar

Journal: Nat Commun

PubMed ID: 38729926

Doi: 10.1038/s41467-024-48234-z

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Computational design of non-porous pH-responsive antibody nanoparticles

Authors: Erin C. Yang, Robby Divine, Marcos C. Miranda, Andrew J. Borst, Will Sheffler, Jason Z. Zhang, Justin Decarreau, Amijai Saragovi, Mohamad Abedi, Nicolas Goldbach, Maggie Ahlrichs, Craig Dobbins, Alexis Hand, Suna Cheng, Mila Lamb, Paul M. Levine, Sidney Chan, Rebecca Skotheim, Jorge Fallas, George Ueda, Joshua Lubner, Masaharu Somiya, Alena Khmelinskaia, Neil P. King & David Baker

Journal: Nat Struct Mol Biol

PubMed ID: 38724718

Doi: 10.1038/s41594-024-01288-5

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Tracking single-cell evolution using clock-like chromatin accessibility loci

Authors: Yu Xiao, Wan Jin, Lingao Ju, Jie Fu, Gang Wang, Mengxue Yu, Fangjin Chen, Kaiyu Qian, Xinghuan Wang & Yi Zhang

Journal: Nature Biotechnol

PubMed ID: 38724668

Doi: 10.1038/s41587-024-02241-z

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Aβ and ROS dual-targeted multifunctional nanocomposite for combination therapy of Alzheimer's disease

Authors: Liding Zhang, Kai Cao, Jun Xie, Xiaohan Liang, Hui Gong, Qingming Luo, Haiming Luo

Journal: J Nanobiotechnology

PubMed ID: 38783363

Doi: 10.1186/s12951-024-02543-z

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Bazi Bushen alleviates reproductive aging in aged male mice

Authors: Kun Ma, Mengnan Li, Yahui Song, Xinjing Mao, Shaolan Zhang, Yaping Zhang, Yuning Jiang, Chuanyuan Ji, Kunxu Niu, Hongrong Li, Yunlong Hou, Cong Wei

Journal: Chin J Nat Med

PubMed ID: 38796215

Doi: 10.1016/S1875-5364(24)60639-4

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The 6-kilodalton peptide 1 in plant viruses of the family Potyviridae is a viroporin

Authors: Mengzhu Chai, Lei Li, Yong Li, Yingshuai Yang, Yuting Wang, Xue Jiang, Yameng Luan, Fangfang Li, Hongguang Cui, Aiming Wang, Wensheng Xiang, Xiaoyun Wu, Xiaofei Cheng

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38739789

Doi: 10.1073/pnas.2401748121

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Discovery of UMI-77 as a novel Ku70/80 inhibitor sensitizing cancer cells to DNA damaging agents in vitro and in vivo

Authors: Xuening Chen, Changkun Chen, Chengmiao Luo, Jianyong Liu, Zhonghui Lin

Journal: Eur J Pharmacol

PubMed ID: 38754534

Doi: 10.1016/j.ejphar.2024.176647

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Identification of a Fully Human Antibody VH Domain Targeting Anaplastic Lymphoma Kinase (ALK) with Applications in ALK-Positive Solid Tumor Immunotherapy

Authors: Chuan Chen, Zehua Sun, Zening Wang, Seungmin Shin, Abigail Berrios, John W Mellors, Dimiter S Dimitrov, Wei Li

Journal: Antibodies (Basel)

PubMed ID: 38804307

Doi: 10.3390/antib13020039

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Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury

Authors: Yuhao Xu, Limoran Tang, Chao Zhou, Liang Sun, Yujie Hu, Zhi Zhang, Shengnan Xia, Xinyu Bao, Haiyan Yang, Yun Xu

Journal: CNS Neurosci Ther

PubMed ID: 38715283

Doi: 10.1111/cns.14742

Products & Services: Proteins, Expression, Isolation and Analysis

YANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway

Authors: Yue Shi, Yue Cheng, Wei Wang, Liu Tang, Wensheng Li, Liyuan Zhang, Zheng Yuan, Feng Zhu, Qiuhong Duan

Journal: Sci Rep

PubMed ID: 38714727

Doi: 10.1038/s41598-024-61157-5

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Functional Characterization of F3H Gene and Optimization of Dihydrokaempferol Biosynthesis in

Authors: Qinyi Chen, Dandan Song, Xiaoyan Sun, Yulong Tian, Zecheng Yan, Ting Min, Hongxun Wang, Limei Wang

Journal: Molecules

PubMed ID: 38792058

Doi: 10.3390/molecules29102196

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Functional Analysis of the Major Pilin Proteins of Type IV Pili in CGMH010

Authors: Yi-Ywan M Chen, Yuan-Chen Yang, Hui-Ru Shieh, Yu-Juan Lin, Wan-Ju Ke, Cheng-Hsun Chiu

Journal: Int J Mol Sci

PubMed ID: 38791440

Doi: 10.3390/ijms25105402

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Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies

Authors: Roman R Schlimgen, Francis C Peterson, Raimond Heukers, Martine J Smit, John D McCorvy, Brian F Volkman

Journal: Nat Commun

PubMed ID: 38816420

Doi: 10.1038/s41467-024-49000-x

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Tardigrade secretory proteins protect biological structures from desiccation

Authors: Samuel Lim, Charles B Reilly, Zeina Barghouti, Benedetto Marelli, Jeffrey C Way, Pamela A Silver

Journal: Commun Biol

PubMed ID: 38796644

Doi: 10.1038/s42003-024-06336-w

Products & Services: Proteins, Expression, Isolation and Analysis

Dexmedetomidine enhances Mitophagy via PINK1 to alleviate hippocampal neuronal Pyroptosis and improve postoperative cognitive dysfunction in elderly rat

Authors: Yayu Chen, Gen Wei, Lieliang Zhang, Xiaojin Feng, Enjun Lei

Journal: Exp Neurol

PubMed ID: 38823674

Doi: 10.1016/j.expneurol.2024.114842

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Distinct components of nucleoside-modified messenger RNA vaccines cooperate to instruct efficient germinal center responses

Authors: Emily Bettini, Aleksey Chudnovskiy, Giulia Protti, Sandra Nakadakari-Higa, Simona Ceglia, Diana Castaño, Joy Chiu, Hiromi Muramatsu, Thandiswa Mdluli, Edit Abraham, Zoltan Lipinszki, Ivan Maillard, Ying K Tam, Andrea Reboldi, Norbert Pardi, Roberto Spreafico, Gabriel D Victora, Michela Locci

Journal: biorxiv

PubMed ID: 38798523

Doi: 10.1101/2024.05.17.594726

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Single dual-specific anti-PD-L1/TGF-β antibody synergizes with chemotherapy as neoadjuvant treatment for pancreatic ductal adenocarcinoma: a preclinical experimental study

Authors: Haoxiang Zhang, Jiaoshun Chen, Jianwei Bai, Jing Zhang, Shaoyi Huang, Liang Zeng, Pengfei Zhou, Qiang Shen, Tao Yin

Journal: Int J Surg

PubMed ID: 38489548

Doi: 10.1097/JS9.0000000000001226

Products & Services: Proteins, Expression, Isolation and Analysis

HSD17B13 liquid-liquid phase separation promotes leukocyte adhesion in chronic liver inflammation

Authors: Jing Ye, Xiyu Huang, Manman Yuan, Jinglin Wang, Ru Jia, Tianyi Wang, Yang Tan, Shun Zhu, Qiang Xu, Xingxin Wu

Journal: J Mol Cell Biol

PubMed ID: 38692847

Doi: 10.1093/jmcb/mjae018

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Establishment of an ELISA Based on a Recombinant Antigenic Protein Containing Multiple Prominent Epitopes for Detection of African Swine Fever Virus Antibodies

Authors: Dossêh Jean Apôtre Afayibo, Zhonghui Zhang, Hualin Sun, Jingsheng Fu, Yaru Zhao, Tharheer Oluwashola Amuda, Mengli Wu, Junzheng Du, Guiquan Guan, Qingli Niu, Jifei Yang, Hong Yin

Journal: Microorganisms

PubMed ID: 38792774

Doi: 10.3390/microorganisms12050943

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A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy

Authors: Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Takakuni Maki, Shu-Ichi Matsuzawa, Ryosuke Takahashi, Hodaka Yamakado

Journal: Mol Brain

PubMed ID: 38790036

Doi: 10.1186/s13041-024-01104-7

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Ser/Leu-swapped cell-free translation system constructed with natural/in vitro transcribed-hybrid tRNA set

Authors: Tomoshige Fujino, Ryogo Sonoda, Taito Higashinagata, Emi Mishiro-Sato, Keiko Kano, Hiroshi Murakami

Journal: Nat Commun

PubMed ID: 38755134

Doi: 10.1038/s41467-024-48056-z

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Oriented immobilization of antibodies through peptide ligands for ultrasensitive detection of gastrin 17 in human serum via lateral flow immunoassay

Authors: Xintong Li , Jiale Cui , Jin Li , Yulian Wang , Guoqing Shi

Journal: Microchemical Journal

Doi: j.microc.2024.110819

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Semi-rational design for enhancing thermostability of Culex pipiens acetylcholinesterase and sensitivity analysis of acephate

Authors: Shuoqi Jiang, Zhuangwei Zhang, Qiuya Gu, Xiaobin Yu

Journal: Sci Total Environ

PubMed ID: 38759926

Doi: 10.1016/j.scitotenv.2024.173282

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Saccharomyces cerevisiae oral immunization in mice using multi-antigen of the African swine fever virus elicits a robust immune response

Authors: Shuo Gao, Wenfeng Zuo, Chao Kang, Zhong Zou, Kaiqi Zhang, Jun Qiu, Xiaomin Shang, Jingjing Li, Yuanfeng Zhang, Qi Zuo, Ya Zhao, Meilin Jin

Journal: Front Immunol

PubMed ID: 38742108

Doi: 10.3389/fimmu.2024.1373656

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One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse

Authors: Marco Malatesta, Emanuele Fornasier, Martino Luigi Di Salvo, Angela Tramonti, Erika Zangelmi, Alessio Peracchi, Andrea Secchi, Eugenia Polverini, Gabriele Giachin, Roberto Battistutta, Roberto Contestabile, Riccardo Percudani

Journal: Nat Commun

PubMed ID: 38615009

Doi: 10.1038/s41467-024-47466-3

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Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase

Authors: Tao Zhang, Feiyu Zhao, Jinze Li, Xiaodi Sun, Xiyun Zhang, Hejun Wang, Peng Fan, Liangxue Lai, Zhanjun Li, Tingting Sui

Journal: Nucleic Acids Res

PubMed ID: 38366553

Doi: 10.1093/nar/gkae110

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The impact of HBx protein on mitochondrial dynamics and associated signaling pathways strongly depends on the hepatitis B virus genotype

Authors: Anja Schollmeier, Michael Basic, Mirco Glitscher, Eberhard Hildt

Journal: J Virol

PubMed ID: 38629837

Doi: 10.1128/jvi.00424-24

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Efficacy of genotype-matched vaccine against re-emerging genotype V Japanese encephalitis virus

Authors: Jae-Deog Kim, Ah-Ra Lee, Dah-Hyun Moon, Young-Uk Chung, Su-Yeon Hong, Hyo Je Cho, Tae Hyun Kang, Yo Han Jang, Myung Hyun Sohn, Baik-Lin Seong, Sang-Uk Seo

Journal: Emerg Microbes Infect

PubMed ID: 38618740

Doi: 10.1080/22221751.2024.2343910

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Efficient activity screening of new glucuronoyl esterases using a pNP-based assay

Authors: Michael S Madsen, Pedro A Martins, Jane W Agger

Journal: Enzyme Microb Technol

PubMed ID: 38581869

Doi: 10.1016/j.enzmictec.2024.110444

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Food-Grade Expression of Two Laccases in and Study on Their Enzymatic Degradation Characteristics for Mycotoxins

Authors: Zhen Sun, Yingxin You, Huidong Xu, Yang You, Wenjing He, Zhouping Wang, Aitao Li, Yu Xia

Journal: J Agric Food Chem

PubMed ID: 38600054

Doi: 10.1021/acs.jafc.4c00521

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Remotely controlled drug release in deep brain regions of non-human primates

Authors: Matthew G Wilson, Taylor D Webb, Henrik Odéen, Jan Kubanek

Journal: J Control Release

PubMed ID: 38604386

Doi: 10.1016/j.jconrel.2024.04.013

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An Elastin-Derived Composite Matrix for Enhanced Vascularized and Innervated Bone Tissue Reconstruction: From Material Development to Preclinical Evaluation

Authors: Nadia Mahmoudi, Micaela Roque, Bruno Paiva Dos Santos, Hugo Oliveira, Robin Siadous, Sylvie Rey, Elisabeth Garanger, Sébastien Lecommandoux, Sylvain Catros, Bertrand Garbay, Joëlle Amédée Vilamitjana

Journal: Adv Healthc Mater

PubMed ID: 38651610

Doi: 10.1002/adhm.202303765

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Broad-spectrum Delta-BA2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex

Authors: Pei Du, Lei Huang, Yi Fang, Fanfan Zhao, Qianyun Li, Xuehui Ma, Ruiqi Li, Qian Chen, Haifa Shen, Qihui Wang, Hangwen Li, George Fu Gao

Journal: PLoS Pathog

PubMed ID: 38557908

Doi: 10.1371/journal.ppat.1012116

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Durlobactam, a Diazabicyclooctane β-Lactamase Inhibitor, Inhibits BlaC and Peptidoglycan Transpeptidases of

Authors: Mary Nantongo, David C Nguyen, Christopher R Bethel, Magdalena A Taracila, Qing Li, Khalid M Dousa, Eunjeong Shin, Sebastian G Kurz, Liem Nguyen, Barry N Kreiswirth, W Henry Boom, Mark S Plummer, Robert A Bonomo

Journal: ACS Infect Dis

PubMed ID: 38619138

Doi: 10.1021/acsinfecdis.4c00119

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Mechanistic insights into the alternative ribosome recycling by HflXr

Authors: Savannah M Seely, Ritwika S Basu, Matthieu G Gagnon

Journal: Nucleic Acids Res

PubMed ID: 38407413

Doi: 10.1093/nar/gkae128

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Receptor-recognition and antiviral mechanisms of retrovirus-derived human proteins

Authors: Shashank Khare, Miryam I Villalba, Juan C Canul-Tec, Arantza Balsebre Cajiao, Anand Kumar, Marija Backovic, Felix A Rey, Els Pardon, Jan Steyaert, Camilo Perez, Nicolas Reyes

Journal: Nat Struct Mol Biol

PubMed ID: 38671230

Doi: 10.1038/s41594-024-01295-6

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CDK5-mediated rearrangement of vimentin during Duck Tembusu virus infection inhibits viral replication

Authors: Guangbin Bao, Shinuo Fan, Chunyan Hu, Chen Li, Fei Ma, Guijun Wang, Hongjie Fan, Qing Wang

Journal: Vet Microbiol

PubMed ID: 38574695

Doi: 10.1016/j.vetmic.2024.110071

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The Trimeric Autotransporter Adhesin SadA from spp as a Novel Bacterial Surface Display System

Authors: Shuli Sang, Wenge Song, Lu Lu, Qikun Ou, Yiyan Guan, Haoxia Tao, Yanchun Wang, Chunjie Liu

Journal: Vaccines (Basel)

PubMed ID: 38675781

Doi: 10.3390/vaccines12040399

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Plasmodium RNA triphosphatase validation as antimalarial target

Authors: Sonia Moliner-Cubel, Noemi Bahamontes-Rosa, Ane Rodriguez-Alejandre, Pamela M Nassau, Argyrides Argyrou, Anshu Bhardwaja, Rachel C Buxton, David Calvo-Vicente, Bernadette Mouzon, William McDowell, Alfonso Mendoza-Losana, Maria G Gomez-Lorenzo

Journal: Int J Parasitol Drugs Drug Resist

PubMed ID: 38810336

Doi: 10.1016/j.ijpddr.2024.100537

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Knockdown of heat shock protein family D member 1 (HSPD1) in lung cancer cell altered secretome profile and cancer-associated fibroblast induction

Authors: Siripat Aluksanasuwan, Keerakarn Somsuan, Jatuporn Ngoenkam, Wararat Chiangjong, Artitaya Rongjumnong, Atthapan Morchang, Somchai Chutipongtanate, Sutatip Pongcharoen

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 38663552

Doi: 10.1016/j.bbamcr.2024.119736

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Two mosquito salivary antigens demonstrate promise as biomarkers of recent exposure to infected mosquito bites

Authors: Sarah Lapidus, Morgan M Goheen, Mouhamad Sy, Awa B Deme, Ibrahima Mbaye Ndiaye, Younous Diedhiou, Amadou Moctar Mbaye, Kelly A Hagadorn, Seynabou Diouf Sene, Mariama Nicole Pouye, Laty Gaye Thiam, Aboubacar Ba, Noemi Guerra, Alassane Mbengue, Hamidah Raduwan, Inés Vigan-Womas, Sunil Parikh, Albert I Ko, Daouda Ndiaye, Erol Fikrig, Yu-Min Chuang, Amy K Bei

Journal: medrxiv

PubMed ID: 38712295

Doi: 10.1101/2024.04.20.24305430

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Specificity of DNA ADP-Ribosylation Reversal by NADARs

Authors: Bara Cihlova, Yang Lu, Andreja Mikoč, Marion Schuller, Ivan Ahel

Journal: Toxins (Basel)

PubMed ID: 38787060

Doi: 10.3390/toxins16050208

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Development of an isotope dilution mass spectrometry assay for the quantification of insulin based on signature peptide analysis

Authors: Shangying Ma, Rimei He, Tingting Jiang, Zhishang Hu, Zihong Ye, Wei Mi

Journal: Anal Bioanal Chem

PubMed ID: 38556594

Doi: 10.1007/s00216-024-05258-0

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Blue light induced ferroptosis via STAT3/GPX4/SLC7A11/FTH1 in conjunctiva epithelium in vivo and in vitro

Authors: Qianjie Yang, Yutong Xia, Kuangqi Chen, Yinhao Wang, Dongjie Song, Jiru Zhu, Jianping Tong, Ye Shen

Journal: J Photochem Photobiol B

PubMed ID: 38663336

Doi: 10.1016/j.jphotobiol.2024.112908

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iJAZ-based approach to engineer lepidopteran pest resistance in multiple crop species

Authors: Huijuan Mo, Huimin Chang, Ge Zhao, Guanjing Hu, Xiumei Luo, Xue Jia, Zhenlu Xu, Guangming Ren, Li Feng, Jonathan F Wendel, Xiaoya Chen, Maozhi Ren, Fuguang Li

Journal: Nat Plants

PubMed ID: 38684916

Doi: 10.1038/s41477-024-01682-3

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Specifically targeting antimicrobial peptides for inhibition of Candidatus Liberibacter asiaticus

Authors: Samavath Mallawarachchi, Haoqi Wang, Nirmitee Mulgaonkar, Sonia Irigoyen, Carmen Padilla, Kranthi Mandadi, James Borneman, Sandun Fernando

Journal: J Appl Microbiol

PubMed ID: 38509024

Doi: 10.1093/jambio/lxae061

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The transcription factor BMI1 increases hypoxic signaling in oral cavity epithelia

Authors: Jorge Baquero, Xiao-Han Tang, Annalisa Ferrotta, Tuo Zhang, Krysta M DiKun, Lorraine J Gudas

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 38599260

Doi: 10.1016/j.bbadis.2024.167161

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LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation

Authors: Meng Li, Yali Hou, Yuzheng Zhou, Zhenni Yang, Hongyu Zhao, Tao Jian, Qianxi Yu, Fuxing Zeng, Xiaotian Liu, Zheng Zhang, Yan G Zhao

Journal: J Cell Biol

PubMed ID: 38587486

Doi: 10.1083/jcb.202309140

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Combined sensory, volatilome and transcriptome analyses identify a limonene terpene synthase as a major contributor to the characteristic aroma of a Coffea arabica L specialty coffee

Authors: Lison Marie, Jean-Christophe Breitler, Pingdwende Kader Aziz Bamogo, Mélanie Bordeaux, Séverine Lacombe, Maëlle Rios, Marc Lebrun, Renaud Boulanger, Eveline Lefort, Sunao Nakamura, Yudai Motoyoshi, Delphine Mieulet, Claudine Campa, Laurent Legendre, Benoît Bertrand

Journal: BMC Plant Biol

PubMed ID: 38566027

Doi: 10.1186/s12870-024-04890-3

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