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Scanning mutagenesis of the voltage-gated sodium channel Na12 using base editing

Authors: Juan Lorenzo B Pablo, Savannah L Cornett, Lei A Wang, Sooyeon Jo, Tobias Brünger, Nikita Budnik, Mudra Hegde, Jean-Marc DeKeyser, Christopher H Thompson, John G Doench, Dennis Lal, Alfred L George, Jen Q Pan

Journal: Cell Rep

PubMed ID: 38823014

Doi: 10.1016/j.celrep.2024.114327

Products & Services: Gene Synthesis

Automated characterization and analysis of expression compatibility between regulatory sequences and metabolic genes in

Authors: Xiao Wen, Jiawei Lin, Chunhe Yang, Ying Li, Haijiao Cheng, Ye Liu, Yue Zhang, Hongwu Ma, Yufeng Mao, Xiaoping Liao, Meng Wang

Journal: Synth Syst Biotechnol

PubMed ID: 38817827

Doi: 10.1016/j.synbio.2024.05.010

Products & Services: Mutagenesis Services

The pioneer transcription factor Zelda facilitates the exit from regeneration and restoration of patterning in

Authors: Anish Bose, Keaton Schuster, Chandril Kodali, Surabhi Sonam, Rachel Smith-Bolton

Journal: biorxiv

PubMed ID: 38854062

Doi: 10.1101/2024.05.30.596672

Products & Services: Proteins, Expression, Isolation and Analysis

Optimization of quenched fluorescent peptide substrates of SARS-CoV-2 3CL main protease (Mpro) from proteomic identification of P6-P6' active site specificity

Authors: Hugo Cesar Ramos de Jesus, Nestor Solis, Yoan Machado, Isabel Pablos, Peter A Bell, Reinhild Kappelhoff, Peter M Grin, Carlos A Sorgi, Georgina S Butler, Christopher M Overall

Journal: J Virol

PubMed ID: 38742901

Doi: 10.1128/jvi.00049-24

Products & Services: Peptide Synthesis

How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism

Authors: David Eisenberg, Ke Hou, Peng Ge, Michael Sawaya, Joshua Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli Feigon

Journal: Res Sq

PubMed ID: 38766197

Doi: 10.21203/rs.3.rs-4152095/v1

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A vector system for single and tandem expression of cloned genes and multi-colour fluorescent tagging in

Authors: Solenne Ithurbide, Roshali T de Silva, Hannah J Brown, Vinaya Shinde, Iain G Duggin

Journal: Microbiology (Reading)

PubMed ID: 38787390

Doi: 10.1099/mic.0.001461

Products & Services: Proteins, Expression, Isolation and Analysis

Plasmodium falciparum Glutamic Acid-Rich Protein-Independent Polyclonal Antibodies Inhibit Malaria Parasite Growth in Human Erythrocytes

Authors: Christopher J Schwake, Rachel M Krueger, Toshihiko Hanada, Athar H Chishti

Journal: J Infect Dis

PubMed ID: 38298126

Doi: 10.1093/infdis/jiae050

Products & Services: Molecular Biology Reagents

mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models

Authors: Xuesong Wang, Christopher A Cottrell, Xiaozhen Hu, Rashmi Ray, Maria Bottermann, Paula Maldonado Villavicencio, Yu Yan, Zhenfei Xie, John E Warner, Jordan Renae Ellis-Pugh, Oleksandr Kalyuzhniy, Alessia Liguori, Jordan R Willis, Sergey Menis, Sebastian Rämisch, Saman Eskandarzade, Michael Kubitz, Ryan Tingle Nicole Phelps, Bettina Groschel, Sunny Himansu, Andrea Carfi, Kathrin H Kirsch, Stephanie R Weldon, Usha Nair, William R Schief, Facundo D Batista

Journal: Science immunology

PubMed ID: 38753808

Doi: 10.1126/sciimmunol.adn0622

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F Nucleatum enhances oral squamous cell carcinoma proliferation via E-cadherin/β-Catenin pathway

Authors: Zhengrui Li, Yuan Liu, Xufeng Huang, Qi Wang, Rao Fu, Xutao Wen, Ji'an Liu, Ling Zhang

Journal: BMC Oral Health

PubMed ID: 38698370

Doi: 10.1186/s12903-024-04252-3

Products & Services: Proteins, Expression, Isolation and Analysis

Immunogenicity Analysis and Identification of Potential T-Cell Epitopes in C129R Protein of African Swine Fever Virus

Authors: Wenzhu Zhai, Ying Huang, Yuheng He, Yuanyuan Chu, Chunhao Tao, Zhongbao Pang, Zhen Wang, Hongfei Zhu, Hong Jia

Journal: Microorganisms

PubMed ID: 38930438

Doi: 10.3390/microorganisms12061056

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Detection of SARS-CoV-2-Specific Secretory IgA and Neutralizing Antibodies in the Nasal Secretions of Exposed Seronegative Individuals

Authors: Jason S Chwa, Minjun Kim, Yesun Lee, Wesley A Cheng, Yunho Shin, Jaycee Jumarang, Jeffrey M Bender, Pia S Pannaraj

Journal: Viruses

PubMed ID: 38932145

Doi: 10.3390/v16060852

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and gene-edited human induced pluripotent stem cells for dissecting the functional roles of -GlcNAcylation in hematopoiesis

Authors: Sudjit Luanpitpong, Kantpitchar Tangkiettrakul, Xing Kang, Pimonwan Srisook, Jirarat Poohadsuan, Parinya Samart, Phatchanat Klaihmon, Montira Janan, Chanchao Lorthongpanich, Chuti Laowtammathron, Surapol Issaragrisil

Journal: Front Cell Dev Biol

PubMed ID: 38752196

Doi: 10.3389/fcell.2024.1361943

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Integrating cryo-OrbiSIMS with computational modelling and metadynamics simulations enhances RNA structure prediction at atomic resolution

Authors: Shannon Ward, Alex Childs, Ceri Staley, Christopher Waugh, Julie A Watts, Anna M Kotowska, Rahul Bhosale, Aditi N Borkar

Journal: Nat Commun

PubMed ID: 38777820

Doi: 10.1038/s41467-024-48694-3

Products & Services: Molecular Biology Reagents

Combinatorial Metabolic Engineering for Improving Betulinic Acid Biosynthesis in

Authors: Mei Tang, Xianhao Xu, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu

Journal: ACS Synth Biol

PubMed ID: 38748665

Doi: 10.1021/acssynbio.4c00104

Products & Services: Codon Optimization

Fluorescence Sensing of Eclampsia Biomarkers via the Immunosorbent Atom Transfer Radical Polymerization Assay

Authors: Nan Ma, Jian Zhang, Jinming Kong, Xueji Zhang

Journal: Anal Chem

PubMed ID: 38728011

Doi: 10.1021/acs.analchem.4c00110

Products & Services: Proteins, Expression, Isolation and Analysis

Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement

Authors: Seiji Watanabe, Kangsa Amporndanai, Raheela Awais, Caroline Latham, Muhammad Awais, Paul M O'Neill, Koji Yamanaka, S Samar Hasnain

Journal: Sci Rep

PubMed ID: 38802492

Doi: 10.1038/s41598-024-62903-5

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Molecular characteristics of Echinococcus multilocularis FABP1 and its regulatory functions on murine macrophages

Authors: Xiang Li, Peng Liao, Wenjing Zhou, Xinqi Yang, Bin Ye

Journal: Acta Trop

PubMed ID: 38729330

Doi: 10.1016/j.actatropica.2024.107247

Products & Services: Proteins, Expression, Isolation and Analysis

Development and application of a cycleave dual-probe fluorescence quantitative PCR method for simultaneous detection of Mycoplasma gallisepticum ts-11 vaccine strain and non-ts-11 strains

Authors: Xue Wang, Nana Sun, Meng Wang, Hui Wang, Yuhan Liu, Hao Shi, Hao Zhu, Peidong Li, Fuyou Zhang, Tianyao Yang, Zhaoyang Li, Chunguo Liu

Journal: Poult Sci

PubMed ID: 38878745

Doi: 10.1016/j.psj.2024.103907

Products & Services: PCR Cloning and Subcloning

Identification of a novel neurovirulence factor encoded by the cryptic orphan gene UL316 of herpes simplex virus 1

Authors: Akihisa Kato, Ryoji Iwasaki, Kousuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Tohru Natsume, Hideo Kusano, Shungo Adachi, Shuichi Kawano, Yasushi Kawaguchi

Journal: J Virol

PubMed ID: 38819171

Doi: 10.1128/jvi.00747-24

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Structural insights into the molecular mechanism of phytoplasma immunodominant membrane protein

Authors: Chang Yi Liu, Han Pin Cheng, Chan Pin Lin, Yi Ting Liao, Tzu Ping Ko, Shin Jen Lin, Shih Shun Lin, Hao Ching Wang

Journal: IUCrJ

PubMed ID: 38656311

Doi: 10.1107/S2052252524003075

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Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo

Authors: Anke Vermehren-Schmaedick, Myron Peto, Wendy Wagoner, Kami E Chiotti, Elizabeth Ramsey, Xiaoyan Wang, Shauna Rakshe, Jessica Minnier, Rosalie Sears, Paul Spellman, Shiuh-Wen Luoh

Journal: PLoS ONE

PubMed ID: 38722955

Doi: 10.1371/journal.pone.0302856

Products & Services: PCR Cloning and Subcloning

A new strategy to generate nanobodies for the coumaphos based on the synthesized nanobody libraries

Authors: Ruyu Fang, Yingxue Li, Fei Liu, Yifan Liang, Yu Wang, Guohua Zhong, Zhenlin Xu, Bruce D Hammock, Hong Wang

Journal: Food Chem

PubMed ID: 38833869

Doi: 10.1016/j.foodchem.2024.139684

Imprinted lncRNA KCNQ1OT1 regulates CDKN1C expression through promoter binding and chromatin folding in pigs

Authors: Yongfeng Zhou, Hao Yu, Daoyu Zhang, Zhengzhu Wang, Qi Li, Xinglan An, Sheng Zhang, Ziyi Li

Journal: Gene

PubMed ID: 38772516

Doi: 10.1016/j.gene.2024.148590

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of phosphorylated small ORF-encoded peptides in Hep3B cells by LC/MS/MS

Authors: Mingbo Peng, Yutian Zhou, Cuihong Wan

Journal: J Proteomics

PubMed ID: 38823442

Doi: 10.1016/j.jprot.2024.105214

Products & Services: Catalog Peptides

Analysis of the molecular basis for the non-amylolytic and non-proteolytic nature of Aspergillus vadensis CBS 113365

Authors: Dujuan Liu, Sandra Garrigues, Helena Culleton, Vincent A McKie, Ronald P de Vries

Journal: N Biotechnol

PubMed ID: 38697469

Doi: 10.1016/j.nbt.2024.04.003

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Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis

Authors: Zhixin Ma, Yu Sun, Yang Yu, Wenjun Xiao, Zhijie Xiao, Tianyu Zhong, Xi Xiang, Zhigang Li

Journal: Cell Commun Signal

PubMed ID: 38802814

Doi: 10.1186/s12964-024-01669-9

Identification and characterisation of novel CAR-T cells to target IL13Rα2 positive human glioma in vitro and in vivo

Authors: Pamela Leland, Heba Degheidy, Ashley Lea, Steven R Bauer, Raj K Puri, Bharat H Joshi

Journal: Clin Transl Med

PubMed ID: 38685487

Doi: 10.1002/ctm2.1664

Products & Services: Codon Optimization

A potent Henipavirus cross-neutralizing antibody reveals a dynamic fusion-triggering pattern of the G-tetramer

Authors: Pengfei Fan, Mengmeng Sun, Xinghai Zhang, Huajun Zhang, Yujiao Liu, Yanfeng Yao, Ming Li, Ting Fang, Bingjie Sun, Zhengshan Chen, Xiangyang Chi, Li Chen, Cheng Peng, Zhen Chen, Guanying Zhang, Yi Ren, Zixuan Liu, Yaohui Li, Jianmin Li, Entao Li, Wuxiang Guan, Shanshan Li, Rui Gong, Kaiming Zhang, …Sandra Chiu

Journal: Nat Commun

PubMed ID: 38773072

Doi: 10.1038/s41467-024-48601-w

Products & Services: Proteins, Expression, Isolation and Analysis

Poc1 bridges basal body inner junctions to promote triplet microtubule integrity and connections

Authors: Marisa D Ruehle, Sam Li, David A Agard, Chad G Pearson

Journal: J Cell Biol

PubMed ID: 38743010

Doi: 10.1083/jcb.202311104

Products & Services: Molecular Biology Reagents

CRISPR/Cas9-Mediated Knockout of the Lycopene ε-Cyclase for Efficient Astaxanthin Production in the Green Microalga

Authors: Jacob Sebastian Kneip, Niklas Kniepkamp, Junhwan Jang, Maria Grazia Mortaro, EonSeon Jin, Olaf Kruse, Thomas Baier

Journal: Plants (Basel)

PubMed ID: 38794462

Doi: 10.3390/plants13101393

Products & Services: PCR Cloning and Subcloning Gene Synthesis

Structure and genome editing of type I-B CRISPR-Cas

Authors: Meiling Lu, Chenlin Yu, Yuwen Zhang, Wenjun Ju, Zhi Ye, Chenyang Hua, Jinze Mao, Chunyi Hu, Zhenhuang Yang & Yibei Xiao

Journal: Nat Commun

PubMed ID: 38750051

Doi: 10.1038/s41467-024-48598-2

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Thalidomide derivatives degrade BCL-2 by reprogramming the binding surface of CRBN

Authors: Jianhui Wang (王建辉) , Marcel Heinz, Kang Han (韩康), Varun J. Shah, Sebastian Hasselbeck, Martin P. Schwalm, Rajeshwari Rathore, Gerhard Hummer, Jun Zhou (周俊), Ivan Dikic, Xinlai Cheng (承辛来)

Journal: Cell Reports Physical Science

Doi: doi.org/10.1016/j.xcrp.2024.101960

Products & Services: Molecular Biology Reagents

A PACAP-activated network for secretion requires coordination of Ca influx and Ca mobilization

Authors: Xiaohuan Chen, Nicole A Bell, Breanna L Coffman, Agustin A Rabino, Rafael Garcia-Mata, Paul J Kammermeier, David I Yule, Daniel Axelrod, Alan V Smrcka, David R Giovannucci, Arun Anantharam

Journal: Mol Biol Cell

PubMed ID: 38758660

Doi: 10.1091/mbc.E24-02-0083

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Polyglutamine-mediated ribotoxicity disrupts proteostasis and stress responses in Huntington's disease

Authors: Ranen Aviner, Ting-Ting Lee, Vincent B Masto, Kathy H Li, Raul Andino, Judith Frydman

Journal: Nat Cell Biol

PubMed ID: 38741019

Doi: 10.1038/s41556-024-01414-x

Products & Services: ORF cDNA Clones/MolecularCloud

Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools Monitoring Targeted Protein Degradation

Authors: Hanfeng Lin, Kristin Riching, May Poh Lai, Dong Lu, Ran Cheng, Xiaoli Qi, Jin Wang

Journal: biorxiv

PubMed ID: 38798562

Doi: 10.1101/2024.05.14.594249

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Two-point immobilization of M3 muscarinic receptor: a method for recognizing receptor antagonists in natural products

Authors: Xiaomin Huang, Ting Wang, Ludan Wang, Yantao Sun, Ziru Zhang, Yajun Zhang

Journal: BMC Chem

PubMed ID: 38702791

Doi: 10.1186/s13065-024-01198-z

Products & Services: DNA Sequencing

Novel enzymes for biodegradation of polycyclic aromatic hydrocarbons identified by metagenomics and functional analysis in short-term soil microcosm experiments

Authors: Kinga K Nagy, Kristóf Takács, Imre Németh, Bálint Varga, Vince Grolmusz, Mónika Molnár, Beáta G Vértessy

Journal: Sci Rep

PubMed ID: 38773163

Doi: 10.1038/s41598-024-61566-6

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Nonspecific phospholipases C3 and C4 interact with PIN-FORMED2 to regulate growth and tropic responses in Arabidopsis

Authors: Teng Li, Shujuan Zhang, Shuaibing Yao, Xuebing Li, Qianru Jia, Jingya Yuan, Wenhua Zhang, Xuemin Wang, Qun Zhang

Journal: Plant Cell

PubMed ID: 38442314

Doi: 10.1093/plcell/koae071

Products & Services: Proteins, Expression, Isolation and Analysis

Single-molecule assay guided crRNA optimization enhances specific microRNA detection by CRISPR-Cas12a

Authors: Kaizhao Chen, Wenjun Sun, Mingtian Zhong, Jiaqi Xie, Yongkun Huo, Xiuqi Lu, Ziting Chen, Bo Sun, Xingxu Huang, Xinjie Wang， Ming Liu , Xiaodong Ma, Peixiang Ma

Journal: Sensors and Actuators B: Chemical

Doi: 10.1016/j.snb.2024.135389

Products & Services: Proteins, Expression, Isolation and Analysis

A Customized Biohybrid presenting Cascade Responses to Tumor Microenvironment

Authors: Feiyu Li, Peipei Zhu, Bingzhu Zheng, Zijie Lu, Chao Fang, Yike Fu, Xiang Li

Journal: Adv Mater

PubMed ID: 38723206

Doi: 10.1002/adma.202404901

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C9orf72-Associated Dipeptide Repeat Expansions Perturb ER-Golgi Vesicular Trafficking, Inducing Golgi Fragmentation and ER Stress, in ALS/FTD

Authors: Jessica Sultana, Audrey M G Ragagnin, Sonam Parakh, Sayanthooran Saravanabavan, Kai Ying Soo, Marta Vidal, Cyril Jones Jagaraj, Kunjie Ding, Sharlynn Wu, Sina Shadfar, Emily K Don, Anand Deva, Garth Nicholson, Dominic B Rowe, Ian Blair, Shu Yang, Julie D Atkin

Journal: Mol Neurobiol

PubMed ID: 38722513

Doi: 10.1007/s12035-024-04187-4

Products & Services: PCR Cloning and Subcloning

Disulfidptosis in head and neck squamous carcinoma: Integrative bioinformatic and in-vitro analysis

Authors: Xufeng Huang, Jinyan Yang, Qi Wang, Rao Fu, Xutao Wen, Zhengrui Li, Ling Zhang

Journal: Oral Dis

PubMed ID: 38696646

Doi: 10.1111/odi.14977

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Arg-biodynamers as antibiotic potentiators through interacting with Gram-negative outer membrane lipopolysaccharides

Authors: Mohamed A M Kamal, Justine Bassil, Brigitta Loretz, Anna K H Hirsch, Sangeun Lee, Claus-Michael Lehr

Journal: Eur J Pharm Biopharm

PubMed ID: 38795784

Doi: 10.1016/j.ejpb.2024.114336

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Structural characterization of E22G Aβ fibrils H detected MAS NMR

Authors: Natalie C Golota, Brian Michael, Edward P Saliba, Sara Linse, Robert G Griffin

Journal: Phys Chem Chem Phys

PubMed ID: 38715538

Doi: 10.1039/d4cp00553h

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Cysteine, sodium metabisulfite, and glutathione enhance crosslinking between proteins during high moisture meat analog extrusion processing and may improve the fibrousness of the products

Authors: Jana K Richter, Preston Watanabe, Josh Bernin, Brennan Smith, Rachel Mitacek, Girish M Ganjyal

Journal: J Sci Food Agric

PubMed ID: 38804791

Doi: 10.1002/jsfa.13569

Products & Services: Proteins, Expression, Isolation and Analysis

Nanobody-based immunosensor for the detection of H pylori in saliva

Authors: Mohammad Ia Ahmad, Célia G Amorim, Luay F Abu Qatouseh, Maria C B S M Montenegro

Journal: Biosens Bioelectron

PubMed ID: 38810413

Doi: 10.1016/j.bios.2024.116423

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for Deciphering Selenium-Encoded Peptide and a Pyrolysis-Thermolysis Dietary Model for Minimizing Loss of "KKSe(M)R" during Processing

Authors: Xin Wang, Wei Jia

Journal: J Agric Food Chem

PubMed ID: 38770928

Doi: 10.1021/acs.jafc.4c01638

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Deletion of Asb15b gene can lead to a significant decrease in zebrafish intermuscular bone

Authors: Minghui Niu, Huamin Whang, Zhichao Wu, Shouwen Jiang, Liangbiao Chen

Journal: Gene

PubMed ID: 38754570

Doi: 10.1016/j.gene.2024.148561

CYP116B5-SOX: An artificial peroxygenase for drug metabolites production and bioremediation

Authors: Daniele Giuriato, Gianluca Catucci, Danilo Correddu, Giovanna Di Nardo, Gianfranco Gilardi

Journal: Biotechnol J

PubMed ID: 38719620

Doi: 10.1002/biot.202300664

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Cellular metabolism of substance P produces neurokinin-1 receptor peptide agonists with diminished cyclic AMP signaling

Authors: Tamas Kriska, Jayashree Natarajan, Anja Herrnreiter, Sang-Kyu Park, Sandra L Pfister, Michael J Thomas, Alexander Widiapradja, Scott P Levick, William B Campbell

Journal: Am J Physiol Cell Physiol

PubMed ID: 38798270

Doi: 10.1152/ajpcell.00103.2024

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Cloning and functional characterization of novel human neutralizing anti-interferon-alpha and anti-interferon-beta antibodies

Authors: Emmanouil Papasavvas, Lily Lu, Matthew Fair, Isabela Oliva, Joel Cassel, Sonali Majumdar, Karam Mounzer, Jay R Kostman, Pablo Tebas, Amit Bar-Or, Kar Muthumani, Luis J Montaner

Journal: biorxiv

PubMed ID: 38746170

Doi: 10.1101/2024.05.05.591636

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Na,K-ATPase activity promotes macropinocytosis in colon cancer via Wnt signaling

Authors: Nydia Tejeda-Muñoz, Yagmur Azbazdar, Eric A Sosa, Julia Monka, Pu-Sheng Wei, Grace Binder, Kuo-Ching Mei, Yerbol Z Kurmangaliyev, Edward M De Robertis

Journal: Biol Open

PubMed ID: 38713004

Doi: 10.1242/bio.060269

Products & Services: PCR Cloning and Subcloning

Single-shot dendritic cell targeting SARS-CoV-2 vaccine candidate induces broad, durable and protective systemic and mucosal immunity in mice

Authors: Nicholas You Zhi Cheang, Kai Sen Tan, Peck Szee Tan, Kiren Purushotorma, Wee Chee Yap, Kirsteen McInnes Tullett, Benson Yen Leong Chua, Aileen Ying-Yan Yeoh, Caris Qi Hui Tan, Xinlei Qian, Huixin Chen, Douglas Jie Wen Tay, Irina Caminschi, Yee Joo Tan, Paul Anthony Macary, Chee Wah Tan, Mireille Hanna Lahoud, Sylvie Alonso

Journal: Mol Ther

PubMed ID: 38715364

Doi: 10.1016/j.ymthe.2024.05.003

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Nanoemulsions and nanocapsules as carriers for the development of intranasal mRNA vaccines

Authors: Mireya L Borrajo, Gustavo Lou, Shubaash Anthiya, Philipp Lapuhs, David Moreira Álvarez, Araceli Tobío, María Isabel Loza, Anxo Vidal, María José Alonso

Journal: Drug Deliv Transl Res

PubMed ID: 38811465

Doi: 10.1007/s13346-024-01635-5

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E3 ubiquitin ligase RNF2 protects polymerase ι from destabilization

Authors: Mikolaj Fedorowicz, Agnieszka Halas, Matylda Macias, Ewa Sledziewska-Gojska, Roger Woodgate, Justyna McIntyre

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 38705361

Doi: 10.1016/j.bbamcr.2024.119743

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An integrated multi-omics approach reveals polymethoxylated flavonoid biosynthesis in Citrus reticulata cv Chachiensis

Authors: Jiawen Wen, Yayu Wang, Xu Lu, Huimin Pan, Dian Jin, Jialing Wen, Canzhi Jin, Sunil Kumar Sahu, Jianmu Su, Xinyue Luo, Xiaohuan Jin, Jiao Zhao, Hong Wu, E-Hu Liu, Huan Liu

Journal: Nat Commun

PubMed ID: 38734724

Doi: 10.1038/s41467-024-48235-y

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Early Animal Origin of BACE1 APP/Aβ Proteolytic Function

Authors: James A Langeland, Lillian Baumann, Eva M DeYoung, Raphaela Angelina Varella, Nkatha Mwenda, Alejandro Aguirre, D Blaine Moore

Journal: Biology (Basel)

PubMed ID: 38785802

Doi: 10.3390/biology13050320

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Three in one: An effective and universal vaccine expressing heterologous tandem RBD trimer by rabies virus vector protects mice against SARS-CoV-2

Authors: Jingbo Huang, Weiqi Wang, Hailun Li, Yujie Bai, Yumeng Song, Cuicui Jiao, Hongli Jin, Pei Huang, Haili Zhang, Xianzhu Xia, Feihu Yan, Yuanyuan Li, Hualei Wang

Journal: Antiviral Res

PubMed ID: 38740191

Doi: 10.1016/j.antiviral.2024.105905

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Generation and evaluation of cancer binding capacity of HLA-A2-WT1 complex-targeting antibody

Authors: Xue Yao, Sandro Matosevic

Journal: Immunol Lett

PubMed ID: 38810886

Doi: 10.1016/j.imlet.2024.106881

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Transcriptome dynamics of the BHK21 cell line in response to human coronavirus OC43 infection

Authors: Mianhuan Li, Yang Yang, Pusen Wang, Weitao Que, Lin Zhong, Zhao Cai, Yang Liu, Liang Yang, Yingxia Liu

Journal: Microbiol Res

PubMed ID: 38761489

Doi: 10.1016/j.micres.2024.127750

Products & Services: Proteins, Expression, Isolation and Analysis

TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer

Authors: Yanting Lin, Rui Gao, Dongquan Jing, Yiming Liu, Huijuan Da, Lutz Birnbaumer, Yong Yang, Xinghua Gao, Zhenhua Gao, Qiuhua Cao

Journal: Front Pharmacol

PubMed ID: 38835669

Doi: 10.3389/fphar.2024.1392328

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Crystal structure of human peptidylarginine deiminase type VI (PAD6) provides insights into its inactivity

Authors: Fanomezana M Ranaivoson, Rieke Bande, Isabell Cardaun, Antonio De Riso, Annette Gärtner, Pui Loke, Christina Reinisch, Prasuna Vogirala, Edward Beaumont

Journal: IUCrJ

PubMed ID: 38656308

Doi: 10.1107/S2052252524002549

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CXCR3 participates in asymmetric division of mouse oocytes by modulating actin dynamics

Authors: Wei-Jian Li, Rong-Yang Li, Da-Yu Wang, Ming Shen, Hong-Lin Liu

Journal: Theriogenology

PubMed ID: 38788628

Doi: 10.1016/j.theriogenology.2024.05.028

Products & Services: Proteins, Expression, Isolation and Analysis

Intranasal Vaccination with a Respiratory-Syncytial-Virus-Based Virus-like Particle Displaying the G Protein Conserved Region Induces Severe Weight Loss and Pathology upon Challenge with Wildtype Respiratory Syncytial Virus

Authors: Megolhubino Terhüja, Manjunath Siddappa, Pramila Lamichhane, Chetan D Meshram, Timothy A Snider, Jerry W Ritchey, Antonius G P Oomens

Journal: Viruses

PubMed ID: 38932136

Doi: 10.3390/v16060843

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Systemic LPS Administration Stimulates the Activation of Non-Neuronal Cells in an Experimental Model of Spinal Muscular Atrophy

Authors: Eleni Karafoulidou, Evangelia Kesidou, Paschalis Theotokis, Chrystalla Konstantinou, Maria-Konstantina Nella, Iliana Michailidou, Olga Touloumi, Eleni Polyzoidou, Ilias Salamotas, Ofira Einstein, Athanasios Chatzisotiriou, Marina-Kleopatra Boziki, Nikolaos Grigoriadis

Journal: Cells

PubMed ID: 38727321

Doi: 10.3390/cells13090785

Products & Services: Proteins, Expression, Isolation and Analysis

Investigating the Antimicrobial Effects of a Novel Peptide Derived From Listeriolysin S on , and : An In Silico and In Vitro Study

Authors: Mojgan Sarabi Nobakht, Kaveh Bazyar, Mohammad Sadegh Ghalyanchi Langeroudi, Mandana Mirzaei, Mehdi Goudarzi, Ali Shivaee

Journal: Bioinform Biol Insights

PubMed ID: 38765021

Doi: 10.1177/11779322241252513

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Modified Zhenwu Tang delays chronic renal failure progression by modulating oxidative stress and hypoxic responses in renal proximal tubular epithelial cells

Authors: Yuan-Yuan Zhang, Pei-Pei Jin, Deng-Zhou Guo, Dong Bian

Journal: Heliyon

PubMed ID: 38803876

Doi: 10.1016/j.heliyon.2024.e31265

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 Surveillance of Wild Mice and Rats in North American Cities

Authors: Lisa K F Lee, Chelsea G Himsworth, Natalie Prystajecky, Antonia Dibernardo, L Robbin Lindsay, Theresa M Albers, Rajeev Dhawan, Ken Henderson, Guy Mulder, Harveen K Atwal, Imara Beattie, Bruce K Wobeser, Michael H Parsons, Kaylee A Byers

Journal: Ecohealth

PubMed ID: 38748281

Doi: 10.1007/s10393-024-01679-6

Products & Services: Molecular Biology Reagents

Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes

Authors: Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Zhiya Yu, Sivasish Sindiri, Jared J Gartner, Maria Parkhurst, Sri Krishna, Frank J Lowery, Nikolaos Zacharakis, Lior Levy, Todd D Prickett, Tiffany Benzine, Satyajit Ray, Robert V Masi, Billel Gasmi, Yong Li, Rafiqul Islam, Alakesh Bera, Stephanie L Goff, Paul F Robbins, Steven A Rosenberg

Journal: J Immunother Cancer

PubMed ID: 38816232

Doi: 10.1136/jitc-2023-008645

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Application of MALDI-MS for characterization of fucoidan hydrolysates and screening of endo-fucoidanase activity

Authors: Diego S Reyes-Weiss, Margot Bligh, Nanna Rhein-Knudsen, Jan-Hendrik Hehemann, Manuel Liebeke, Bjørge Westereng, Svein Jarle Horn

Journal: Carbohydr Polym

PubMed ID: 38858030

Doi: 10.1016/j.carbpol.2024.122317

Products & Services: Molecular Biology Reagents

Selective activation of naïve B cells with unique epitope specificity shapes autoantibody formation in celiac disease

Authors: Saykat Das, Jorunn Stamnaes, Lene S Høydahl, Christine Skagen, Knut E A Lundin, Jørgen Jahnsen, Ludvig M Sollid, Rasmus Iversen

Journal: J Autoimmun

PubMed ID: 38754235

Doi: 10.1016/j.jaut.2024.103241

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Structural basis for raccoon dog receptor recognition by SARS-CoV-2

Authors: Fu-Chun Hsueh, Ke Shi, Alise Mendoza, Fan Bu, Wei Zhang, Hideki Aihara, Fang Li

Journal: PLoS Pathog

PubMed ID: 38709834

Doi: 10.1371/journal.ppat.1012204

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Development of multiplexed orthogonal base editor (MOBE) systems

Authors: Quinn T Cowan, Sifeng Gu, Wanjun Gu, Brodie L Ranzau, Tatum S Simonson, Alexis C Komor

Journal: Nat Biotechnol

PubMed ID: 38773305

Doi: 10.1038/s41587-024-02240-0

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Retinal organoids with X-linked retinoschisis RS1 (E72K) mutation exhibit a photoreceptor developmental delay and are rescued by gene augmentation therapy

Authors: Chunwen Duan, Chengcheng Ding, Xihao Sun, Shengru Mao, Yuqin Liang, Xinyu Liu, Xiaoyan Ding, Jiansu Chen, Shibo Tang

Journal: Stem Cell Res Ther

PubMed ID: 38816767

Doi: 10.1186/s13287-024-03767-4

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The Hansenula polymorpha mitochondrial carrier family protein Mir1 is dually localized at peroxisomes and mitochondria

Authors: Marc Pilegaard Pedersen, Justina C Wolters, Rinse de Boer, Arjen M Krikken, Ida J van der Klei

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 38702017

Doi: 10.1016/j.bbamcr.2024.119742

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Loss of a conserved C-terminal region of the AtrR transcriptional regulator leads to a gene-specific defect in target gene expression

Authors: Shivani Ror, Mark A Stamnes, W Scott Moye-Rowley

Journal: biorxiv

PubMed ID: 38826412

Doi: 10.1101/2024.05.22.595332

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Assessing the Impact of Novel Exon 11 Variants on Pre-mRNA Splicing

Authors: Halla Elshwekh, Inas M Alhudiri, Adam Elzagheid, Nabil Enattah, Yasmine Abbassi, Lubna Abou Assali, Ilenia Marino, Cristiana Stuani, Emanuele Buratti, Maurizio Romano

Journal: Cells

PubMed ID: 38786046

Doi: 10.3390/cells13100824

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The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism

Authors: Felipe Paredes, Holly C Williams, Xuesong Liu, Claire Holden, Bethany Bogan, Yu Wang, Kathryn M Crotty, Samantha M Yeligar, Alvaro A Elorza, Zhiyong Lin, Amir Rezvan, Alejandra San Martin

Journal: Redox Biol

PubMed ID: 38823208

Doi: 10.1016/j.redox.2024.103203

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Virus-like particles expressing microneme-associated antigen of Plasmodium berghei confer better protection than those expressing apical membrane antigen 1

Authors: Min-Ju Kim, Ki Back Chu, Keon-Woong Yoon, Hae-Ji Kang, Dong-Hun Lee, Eun-Kyung Moon, Fu-Shi Quan

Journal: Parasites Hosts Dis

PubMed ID: 38835260

Doi: 10.3347/PHD.24017

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Characterization of an agmatine N-acetyltransferase from Bactrocera dorsalis that modulates ovary development

Authors: Fei-Yue Teng, Ji-Mei Feng, Fu-Cai Ma, Zhuo-Xin Wang, Yong-Yue Lu, Yi-Xiang Qi

Journal: Insect Biochem Mol Biol

PubMed ID: 38734116

Doi: 10.1016/j.ibmb.2024.104130

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Prominin 1 is crucial for the early development of photoreceptor outer segments

Authors: Sila Yanardag, Scott Rhodes, Thamaraiselvi Saravanan, Tongju Guan, Visvanathan Ramamurthy

Journal: Sci Rep

PubMed ID: 38714794

Doi: 10.1038/s41598-024-60989-5

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A Naturally Active Spy Transposon Discovered from the Insect Genome of Colletes gigas as a Promising Novel Gene Transfer Tool

Authors: Mohamed Diaby, Han Wu, Bo Gao, Shasha Shi, Bingqing Wang, Saisai Wang, Yali Wang, Zherui Wu, Cai Chen, Xiaoyan Wang, Chengyi Song

Journal: Adv Sci (Weinh)

PubMed ID: 38774947

Doi: 10.1002/advs.202400969

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Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease

Authors: Alexandra M D'Ordine, Gerwald Jogl, John M Sedivy

Journal: Nat Commun

PubMed ID: 38719805

Doi: 10.1038/s41467-024-48066-x

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Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4 regulatory T cells by regulating IL2RA

Authors: Syed Bilal Ahmad Andrabi, Ubaid Ullah Kalim, Senthil Palani, Mohd Moin Khan, Meraj Hasan Khan, Jimmy Fagersund, Julius Orpana, Niklas Paulin, Kedar Batkulwar, Sini Junttila, Tanja Buchacher, Toni Grönroos, Lea Toikka, Tea Ammunet, Partho Sen, Matej Orešič, Venla Kumpulainen, Johanna E E Tuomisto, Rahul Sinha, Alexander Marson, Omid Rasool, Laura L Elo, Riitta Lahesmaa

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38805281

Doi: 10.1073/pnas.2315363121

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The G932C mutation of chitin synthase 1 gene (CHS1) mediates buprofezin resistance as confirmed by CRISPR/Cas9-mediated knock-in approach in the brown planthopper, Nilaparvata lugens

Authors: Fan Zhang, Yan-Chao Zhang, Zhi-Tao Yu, Bing Zeng, Hao Sun, Yu-Qiu Xie, Kun Yan Zhu, Cong-Fen Gao

Journal: Pestic Biochem Physiol

PubMed ID: 38879307

Doi: 10.1016/j.pestbp.2024.105953

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SLC15A3 is transcriptionally regulated by HIF1α and p65 to worsen neuroinflammation in experimental ischemic stroke

Authors: Shan Yu, Jinghui Yang, Rui Zhang, Qian Guo, Lu Wang

Journal: Mol Neurobiol

PubMed ID: 38717559

Doi: 10.1007/s12035-024-04191-8

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Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers

Authors: Sheenam Verma, Matthew J Dufort, Tayla M Olsen, Samantha Kimmel, Jasmine C Labuda, Sam Scharffenberger, Andrew T McGuire, Oliver J Harrison

Journal: Immunity

PubMed ID: 38723638

Doi: 10.1016/j.immuni.2024.04.014

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A cell cycle regulator, E2F2, and glucocorticoid receptor cooperatively transactivate the bovine alphaherpesvirus 1 immediate early transcription unit 1 promoter

Authors: Fouad S El-Mayet, Clinton Jones

Journal: J Virol

PubMed ID: 38771044

Doi: 10.1128/jvi.00423-24

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Identification of key genes affecting ventilator-induced diaphragmatic dysfunction in diabetic mice

Authors: Rongchun Xing, Haibo Yu, Jiangtao Yu, Rong Zeng, Zhijun Xiang, Haoli Ma, Gang Li, Yan Zhao

Journal: Front Genet

PubMed ID: 38784031

Doi: 10.3389/fgene.2024.1387688

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Recombinant Bile Salt Hydrolase Enhances the Inhibition Efficiency of Taurodeoxycholic Acid against Virulence

Authors: Tahrir Alenezi, Bilal Alrubaye, Ying Fu, Janashrit Shrestha, Samar Algehani, Hong Wang, Rohana Liyanage, Xiaolun Sun

Journal: Pathogens

PubMed ID: 38921762

Doi: 10.3390/pathogens13060464

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The three-dimensional structure of DapE from Enterococcus faecium reveals new insights into DapE/ArgE subfamily ligand specificity

Authors: Manuel Terrazas-López, Lilian González-Segura, Adelaida Díaz-Vilchis, Kelly Annecy Aguirre-Mendez, Naún Lobo-Galo, Alejandro Martínez-Martínez, Ángel G Díaz-Sánchez

Journal: Int J Biol Macromol

PubMed ID: 38740150

Doi: 10.1016/j.ijbiomac.2024.132281

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Overexpression of PEX14 results in mistargeting to mitochondria, accompanied by organelle fragmentation and clustering in human embryonic kidney cells

Authors: Renate L M Jansen, Rinse de Boer, Eline M F de Lange, Janet Koster, Rifka Vlijm, Hans R Waterham, Ida J van der Klei

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 38762172

Doi: 10.1016/j.bbamcr.2024.119754

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Biosynthetic production of anticoagulant heparin polysaccharides through metabolic and sulfotransferases engineering strategies

Authors: Jian-Qun Deng, Yi Li, Yu-Jia Wang, Ya-Lin Cao, Si-Yu Xin, Xin-Yu Li, Rui-Min Xi, Feng-Shan Wang & Ju-Zheng Sheng

Journal: Nat Commun

PubMed ID: 38704385

Doi: 10.1038/s41467-024-48193-5

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Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants

Authors: Martin Grønbæk-Thygesen, Vasileios Voutsinos, Kristoffer E. Johansson, Thea K. Schulze, Matteo Cagiada, Line Pedersen, Lene Clausen, Snehal Nariya, Rachel L. Powell, Amelie Stein, Douglas M. Fowler, Kresten Lindorff-Larsen & Rasmus Hartmann-Petersen

Journal: Nat Commun

PubMed ID: 38740822

Doi: 10.1038/s41467-024-48481-0

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A glutathione S-transferase from confers resistance to Fusarium head blight in wheat

Authors: Lanfei Zhao, Amy Bernardo, Fanmei Kong, Wei Zhao, Yanhong Dong, Hyeonju Lee, Harold N Trick, Jessica Rupp Noller, Guihua Bai

Journal: Phytopathology

PubMed ID: 38709206

Doi: 10.1094/PHYTO-03-24-0106-SC

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Development of advanced control material for reverse transcription-mediated bacterial nucleic acid amplification tests

Authors: Janessa D Lewis , Stephen J Salipante

Journal: J Clin Microbiol

PubMed ID: 38629844

Doi: 10.1128/jcm.00243-24

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CRISPR/Cas13a-based supersensitive circulating tumor DNA assay for detecting EGFR mutations in plasma

Authors: Li Wang , Xiaosha Wen , Yang Yang , Zheng Hu , Jing Jiang , Lili Duan , Xiaofen Liao , Yan He , Yaru Liu , Jing Wang , Zhikun Liang , Xiaoya Zhu , Quan Liu , Tiancai Liu , Dixian Luo

Journal: Commun Biol

PubMed ID: 38806596

Doi: 10.1038/s42003-024-06368-2

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Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity

Authors: Min Wu, Guangping Song, Jianing Li, Zengqing Song, Bing Zhao, Liyun Liang, Wenlong Li, Huaibin Hu, Haiqing Tu, Sen Li, Peiyao Li, Biyu Zhang , Wen Wang, Yu Zhang , Wanpeng Zhang, Weifan Zheng, Jiarong Wang, Yuqi Wen, Kai Wang, Ailing Li, Tao Zhou, Yucheng Zhang, Huiyan Li

Journal: Cell

Doi: 10.1016/j.cell.2024.04.027

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The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation

Authors: Joanne Saldanha , Julie Rageul , Jinal A Patel , Amy L Phi , Natalie Lo , Jennifer J Park , Hyungjin Kim

Journal: Nucleic Acids Res

PubMed ID: 38801073

Doi: 10.1093/nar/gkae445.

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Helicases DDX5 and DDX17 promote heterogeneity in HBV transcription termination in infected human hepatocytes

Authors: Fleur Chapus 1, Guillaume Giraud 2, Pélagie Huchon 3, Mélanie Rodà 2, Xavier Grand 2, Caroline Charre 4, Chloé Goldsmith 5, Armando Andres Roca Suarez 2, Maria-Guadalupe Martinez 1, Judith Fresquet 6, Audrey Diederichs 3, Maëlle Locatelli 1, Hélène Polvèche 7, Caroline Scholtès 8, Isabelle Chemin 2, Hector Hernandez Vargas 5, Michel Rivoire 9, Cyril F Bourgeois 10, Fabien Zoulim 11, Barbara Testoni 12

Journal: J Hepatol

PubMed ID: 38782119

Doi: doi: 10.1016/j.jhep.2024.05.016.

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