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The investigation of the role of oral-originated induced inflammation in childhood asthma

Authors: Tongtong Yan, Yuling Bao, Shuyuan Cao, Ping Jiang, Zhan Zhang, Lei Li, Yulin Kang, Qian Wu

Journal: Front Microbiol

PubMed ID: 38863747

Doi: 10.3389/fmicb.2024.1400079

Products & Services: Gene Synthesis

Structural basis for the broad antigenicity of the computationally optimized influenza hemagglutinin X6

Authors: Kaito A Nagashima, John V Dzimianski, Meng Yang, Jan Abendroth, Giuseppe A Sautto, Ted M Ross, Rebecca M DuBois, Thomas E Edwards, Jarrod J Mousa

Journal: Structure

PubMed ID: 38810648

Doi: 10.1016/j.str.2024.05.001

Products & Services: Molecular Biology Reagents

Universal paramyxovirus vaccine design by stabilizing regions involved in structural transformation of the fusion protein

Authors: Johannes P M Langedijk, Freek Cox, Nicole V Johnson, Daan van Overveld, Lam Le, Ward van den Hoogen, Richard Voorzaat, Roland Zahn, Leslie van der Fits, Jarek Juraszek, Jason S McLellan, Mark J G Bakkers

Journal: Nat Commun

PubMed ID: 38821950

Doi: 10.1038/s41467-024-48059-w

Products & Services: Molecular Biology Reagents

Whole-cell one-pot biosynthesis of dodecanedioic acid from renewable linoleic acid

Authors: Yi-Ke Qi, Jiang Pan, Zhi-Jun Zhang, Jian-He Xu

Journal: Bioresour Bioprocess

PubMed ID: 38780695

Doi: 10.1186/s40643-024-00770-8

Products & Services: Gene Synthesis

Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM

Authors: Emil Gustavsson, Kay Grünewald, Per Elias, B Martin Hällberg

Journal: Nucleic Acids Res

PubMed ID: 38806233

Doi: 10.1093/nar/gkae374

Products & Services: Molecular Biology Reagents

Rational design and production of a chimeric antigen targeting Zika virus that induces neutralizing antibodies in mice

Authors: Arleth Miranda-López, Omar González-Ortega, Dania O Govea-Alonso, Lourdes Betancourt-Mendiola, Mauricio Comas-García, Sergio Rosales-Mendoza

Journal: Vaccine

PubMed ID: 38749821

Doi: 10.1016/j.vaccine.2024.04.080

Products & Services: Molecular Biology Reagents

Engineered coiled-coil HIF1α protein domain mimic

Authors: Dustin Britton, Olga Katsara, Orin Mishkit, Andrew Wang, Neelam Pandya, Chengliang Liu, Heather Mao, Jakub Legocki, Sihan Jia, Yingxin Xiao, Orlando Aristizabal, Deven Paul, Yan Deng, Robert Schneider, Youssef Z Wadghiri, Jin Kim Montclare

Journal: Biomater Sci

PubMed ID: 38656316

Doi: 10.1039/d4bm00354c

Products & Services: PCR Cloning and Subcloning

CDKN2A/B homozygous deletion sensitizes IDH-mutant glioma to CDK4/6 inhibition

Authors: Ali M Nasser, Lisa Melamed, Ethan Wetzel, Chia-Chen Chang, Hiroaki Nagashima, Yosuke Kitagawa, Logan Muzyka, Hiroaki Wakimoto, Daniel P Cahill, Julie J Miller

Journal: Clin Cancer Res

PubMed ID: 38718141

Doi: 10.1158/1078-0432.CCR-24-0562

Products & Services: Proteins, Expression, Isolation and Analysis

Glycosyl transferase GT2 genes mediate the biosynthesis of an unusual (1,3;1,4)-β-glucan exopolysaccharide in the bacterium Sarcina ventriculi

Authors: Edwin R Lampugnani, Kris Ford, Yin Ying Ho, Allison van de Meene, Jelle Lahnstein, Hwei-Ting Tan, Rachel A Burton, Geoffrey B Fincher, Thomas Shafee, Antony Bacic, Jochen Zimmer, Xiaohui Xing, Vincent Bulone, Monika S Doblin, Eric M Roberts

Journal: Mol Microbiol

PubMed ID: 38750617

Doi: 10.1111/mmi.15276

Products & Services: DNA Sequencing

Biochemical synthesis of taxanes from mevalonate

Authors: Jing Li, Xiaonan Liu, Xiaoxi Zhu, Jiayu Liu, Lei Zhang, Nida Ahmed, Jian Qi, Bihuan Chen, Daliang Tang, Jinsheng Yu, Zhijin Fan, Huifeng Jiang

Journal: Synth Syst Biotechnol

PubMed ID: 38868609

Doi: 10.1016/j.synbio.2024.05.002

Products & Services: Gene Synthesis

Dimerization and antidepressant recognition at noradrenaline transporter

Authors: Heng Zhang # 1, Yu-Ling Yin # 2, Antao Dai # 3 4, Tianwei Zhang 2 5, Chao Zhang 4 6, Canrong Wu 1, Wen Hu 1 7, Xinheng He 1 8, Benxun Pan 2, Sanshan Jin 2, Qingning Yuan 1 7, Ming-Wei Wang 9 10 11, Dehua Yang 12 13 14, H Eric Xu 15 16 17, Yi Jiang 18 19

Journal: Nature

PubMed ID: 38750358

Doi: 10.1038/s41586-024-07437-6.

Products & Services: Proteins, Expression, Isolation and Analysis

Biochemical characterization of a novel thermostable ulvan lyase from Tamlana fucoidanivorans CW2-9

Authors: Yan Xu, Jin Li, Lu An, Yuankai Qiu, Aihua Mao, Zhixiao He, Jialing Guo, Hanbing Yan, Han Li, Zhong Hu

Journal: J Agric Food Chem

PubMed ID: 38722333

Doi: 10.1021/acs.jafc.4c01717

Products & Services: Proteins, Expression, Isolation and Analysis

Exploring roles of the chitinase ChiC in modulating virulence phenotypes

Authors: Per Kristian Thorén Edvardsen, Fatemeh Askarian, Raymond Zurich, Victor Nizet, Gustav Vaaje-Kolstad

Journal: Microbiol Spectr

PubMed ID: 38819151

Doi: 10.1128/spectrum.00546-24

Products & Services: Proteins, Expression, Isolation and Analysis

Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling

Authors: Zhe Li, Zhi-Min Xu, Wei-Peng Chen, Xiao-Jing Du, Chun-Xian Ou, Zi-Kang Luo, Rong Wang, Chu-Qing Zhang, Chao-Dong Ge, Meng Han, Fudi Wang, Rong-Rong He, Wan-Yang Sun, Jun Ma, Xiao-Yu Liang, Zhuo-Wei Liu

Journal: Nat Chem Biol

PubMed ID: 38720107

Doi: 10.1038/s41589-024-01612-6

Products & Services: Proteins, Expression, Isolation and Analysis

Targeted Clearance of Senescent Cells Via Engineered Extracellular Vesicles Reprograms Tumor Immunosuppressive Microenvironment

Authors: Panpan Ji, Chen Wang, Yang Liu, Xin Guo, Yuan Liang, Jiangpeng Wei, Zhaoyou Liu, Li Gong, Guodong Yang, Gang Ji

Journal: Adv Healthc Mater

PubMed ID: 38794820

Doi: 10.1002/adhm.202400945

Products & Services: Molecular Biology Reagents

Improvement of tumor neoantigen detection by high field asymmetric waveform ion mobility mass spectrometry

Authors: Wei Meng, Yoshiko Takeuchi, Jeffrey P Ward, Hussein Sultan, Cora D Arthur, Elaine R Mardis, Maxim N Artyomov, Cheryl F Lichti, Robert D Schreiber

Journal: Cancer Immunol Res

PubMed ID: 38768391

Doi: 10.1158/2326-6066.CIR-23-0900

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Proteomic and lipidomic landscape of the infrapatellar fat pad and its clinical significance in knee osteoarthritis

Authors: Bizhi Tu, Zheng Zhu, Peizhi Lu, Run Fang, Cheng Peng, Jun Tong, Rende Ning

Journal: Biochim Biophys Acta Mol Cell Biol Lipids

PubMed ID: 38788831

Doi: 10.1016/j.bbalip.2024.159513

Products & Services: Proteins, Expression, Isolation and Analysis

Structural Insights into Subunit-Dependent Functional Regulation in Epithelial Sodium Channels

Authors: Alexandra Houser, Isabelle Baconguis

Journal: biorxiv

PubMed ID: 38853903

Doi: 10.1101/2024.05.28.595834

Products & Services: Molecular Biology Reagents

Evaluating the clinical utility of semi-quantitative luciferase immunosorbent assay using antigens in syphilis diagnosis and treatment monitoring

Authors: Wujian Ke, Cailing Ao, Ran Wei, Xiaozhen Zhu, Jingwei Shui, Jianhui Zhao, Xiaohui Zhang, Liuyuan Wang, Liping Huang, Xinying Leng, Rui Zhu, Jiaxin Wu, Lixia Huang, Nanxuan Huang, Haiying Wang, Wenjia Weng, Ligang Yang, Shixing Tang

Journal: Emerg Microbes Infect

PubMed ID: 38661428

Doi: 10.1080/22221751.2024.2348525

Products & Services: Proteins, Expression, Isolation and Analysis

Design and Evaluation of a Humanized Anti-EGFR huscFv Antibody Fragment in Combination With Metformin in A549 Cells

Authors: Jorge Solis-Estrada, Eder Arredondo-Espinoza, Elizeth Pioquinto-Ávila, Aldo O González-Cruz, Xristo Zarate, Isaías Balderas-Rentería

Journal: Anticancer Res

PubMed ID: 38677771

Doi: 10.21873/anticanres.16998

Products & Services: Proteins, Expression, Isolation and Analysis

Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones

Authors: Jennifer A Smith, Benjamin T K Yuen, Whitney Purtha, Jared M Balolong, Jonah D Phipps, Frances Crawford, Jeffrey A Bluestone, John W Kappler, Mark S Anderson

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38709934

Doi: 10.1073/pnas.2320268121

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Optimizing interleukin-6 and 8 expression, clarification and purification in plant cell packs and plants for application in advanced therapy medicinal products and cellular agriculture

Authors: P Opdensteinen, J F Buyel

Journal: J Biotechnol

PubMed ID: 38740307

Doi: 10.1016/j.jbiotec.2024.05.003

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HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice

Authors: Laiqiang Chen, Yiyang Qin, Tingting Guo, Wenzhen Zhu, Jingpan Lin, Tingting Xing, Xuezhi Duan, Yiran Zhang, Eshu Ruan, Xiang Li, Peng Yin, Shihua Li, Xiao-Jiang Li, Su Yang

Journal: Cell Death Dis

PubMed ID: 38744826

Doi: 10.1038/s41419-024-06716-4

Products & Services: Proteins, Expression, Isolation and Analysis

Evolved histone tail regulates 53BP1 recruitment at damaged chromatin

Authors: Jessica L Kelliher, Melissa L Folkerts, Kaiyuan V Shen, Wan Song, Kyle Tengler, Clara M Stiefel, Seong-Ok Lee, Eloise Dray, Weixing Zhao, Brian Koss, Nicholas R Pannunzio, Justin W Leung

Journal: Nat Commun

PubMed ID: 38821984

Doi: 10.1038/s41467-024-49071-w

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A 3D spheroid model of quadruple cell co-culture with improved liver functions for hepatotoxicity prediction

Authors: Baiyang Sun, Zihe Liang, Yupeng Wang, Yue Yu, Xiaobing Zhou, Xingchao Geng, Bo Li

Journal: Toxicology

PubMed ID: 38740170

Doi: 10.1016/j.tox.2024.153829

Products & Services: Proteins, Expression, Isolation and Analysis

Development of a Fully Protective Pandemic Avian Influenza Subunit Vaccine in Insect Pupae

Authors: Ana Falcón, Susana Martínez-Pulgarín, Sergi López-Serrano, Edel Reytor, Miguel Cid, Maria Del Carmen Nuñez, Lorena Córdoba, Ayub Darji, José M Escribano

Journal: Viruses

PubMed ID: 38932122

Doi: 10.3390/v16060829

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Structural mechanisms of Tad pilus assembly and its interaction with an RNA virus

Authors: Yuhang Wang, Matthew Theodore, Zhongliang Xing, Utkarsh Narsaria, Zihao Yu, Lanying Zeng, Junjie Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 38701202

Doi: 10.1126/sciadv.adl4450

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TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington’s disease

Authors: Yiyang Qin, Laiqiang Chen, Wenzhen Zhu, Jiahong Song, Jingpan Lin, Yuwei Li, Jiawei Zhang, Xichen Song, Tingting Xing, Tingting Guo, Xuezhi Duan, Yiran Zhang, Eshu Ruan, Qi Wang, Bang Li, Weili Yang , Peng Yin, Xiao-Xin Yan, Shihua Li, Xiao-Jiang Li, Su Yang

Journal: SCIENCE ADVANCES

PubMed ID: 38758800

Doi: 10.1126/sciadv.adl2036

Products & Services: Proteins, Expression, Isolation and Analysis

In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model

Authors: Melisa Benard-Valle, Yessica Wouters, Anne Ljungars, Giang Thi Tuyet Nguyen, Shirin Ahmadi, Tasja Wainani Ebersole, Camilla Holst Dahl, Alid Guadarrama-Martínez, Frederikke Jeppesen, Helena Eriksen, Gibran Rodríguez-Barrera, Kim Boddum, Timothy Patrick Jenkins, Sara Petersen Bjørn, Sanne Schoffelen, Bjørn Gunnar Voldborg, Alejandro Alagón & Andreas Hougaard Laustsen

Journal: Nat Commun

PubMed ID: 38773068

Doi: 10.1038/s41467-024-48539-z

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Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers

Authors: Di Yin # 1, Yiye Zhong # 1, Sikai Ling # 1 2, Sicong Lu # 1, Xiaoyuan Wang # 2, Zhuofan Jiang 1, Jie Wang 1, Yao Dai 1, Xiaolong Tian 3, Qijing Huang 1, Xingbo Wang 4, Junsong Chen 1, Ziying Li 1, Yang Li 1, Zhijue Xu 1, Hewei Jiang 1, Yuqing Wu 5, Yi Shi 6, Quanjun Wang 7, Jianjiang Xu 5, Wei Hong 8 9, Heng Xue 8 9, Hang Yang 8 9 10, Yan Zhang 1, Lintai Da 1, Ze-Guang Han 1, Sheng-Ce Tao 1, Ruijiao Dong 1, Tianlei Ying 3, Jiaxu Hong 11, Yujia Cai 12

Journal: Nat Biomed Eng

PubMed ID: 38714892

Doi: 10.1038/s41551-024-01208-4

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Impact of N-Glycosylation on Protein Structure and Dynamics Linked to Enzymatic C–H Activation in the M. oryzae Lipoxygenase

Authors: Chris Whittington, Ajay Sharma, S Gage Hill, Anthony T Iavarone, Brian M Hoffman, Adam R Offenbacher

Journal: Biochemistry

PubMed ID: 38690768

Doi: 10.1021/acs.biochem.4c00109

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Manganese-dependent transcription regulation by MntR and PerR in Thermus thermophilus HB8

Authors: John K Barrows, Kamya A Stubbs, Irina F Padilla-Montoya, Thomas C Leeper, Michael W Van Dyke

Journal: Mol Microbiol

PubMed ID: 38735869

Products & Services: Nucleic Acid Purification & Analysis

Delineating organizational principles of the endogenous L-A virus by cryo-EM and computational analysis of native cell extracts

Authors: Lisa Schmidt, Christian Tüting, Fotis L Kyrilis, Farzad Hamdi, Dmitry A Semchonok, Gerd Hause, Annette Meister, Christian Ihling, Milton T Stubbs, Andrea Sinz, Panagiotis L Kastritis

Journal: Commun Biol

PubMed ID: 38730276

Doi: 10.1038/s42003-024-06204-7

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Combinatorial Metabolic Engineering for Improving Betulinic Acid Biosynthesis in

Authors: Mei Tang, Xianhao Xu, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu

Journal: ACS Synth Biol

PubMed ID: 38748665

Doi: 10.1021/acssynbio.4c00104

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and gene-edited human induced pluripotent stem cells for dissecting the functional roles of -GlcNAcylation in hematopoiesis

Authors: Sudjit Luanpitpong, Kantpitchar Tangkiettrakul, Xing Kang, Pimonwan Srisook, Jirarat Poohadsuan, Parinya Samart, Phatchanat Klaihmon, Montira Janan, Chanchao Lorthongpanich, Chuti Laowtammathron, Surapol Issaragrisil

Journal: Front Cell Dev Biol

PubMed ID: 38752196

Doi: 10.3389/fcell.2024.1361943

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Integrating cryo-OrbiSIMS with computational modelling and metadynamics simulations enhances RNA structure prediction at atomic resolution

Authors: Shannon Ward, Alex Childs, Ceri Staley, Christopher Waugh, Julie A Watts, Anna M Kotowska, Rahul Bhosale, Aditi N Borkar

Journal: Nat Commun

PubMed ID: 38777820

Doi: 10.1038/s41467-024-48694-3

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Fluorescence Sensing of Eclampsia Biomarkers via the Immunosorbent Atom Transfer Radical Polymerization Assay

Authors: Nan Ma, Jian Zhang, Jinming Kong, Xueji Zhang

Journal: Anal Chem

PubMed ID: 38728011

Doi: 10.1021/acs.analchem.4c00110

Products & Services: Proteins, Expression, Isolation and Analysis

Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement

Authors: Seiji Watanabe, Kangsa Amporndanai, Raheela Awais, Caroline Latham, Muhammad Awais, Paul M O'Neill, Koji Yamanaka, S Samar Hasnain

Journal: Sci Rep

PubMed ID: 38802492

Doi: 10.1038/s41598-024-62903-5

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Molecular characteristics of Echinococcus multilocularis FABP1 and its regulatory functions on murine macrophages

Authors: Xiang Li, Peng Liao, Wenjing Zhou, Xinqi Yang, Bin Ye

Journal: Acta Trop

PubMed ID: 38729330

Doi: 10.1016/j.actatropica.2024.107247

Products & Services: Proteins, Expression, Isolation and Analysis

Development and application of a cycleave dual-probe fluorescence quantitative PCR method for simultaneous detection of Mycoplasma gallisepticum ts-11 vaccine strain and non-ts-11 strains

Authors: Xue Wang, Nana Sun, Meng Wang, Hui Wang, Yuhan Liu, Hao Shi, Hao Zhu, Peidong Li, Fuyou Zhang, Tianyao Yang, Zhaoyang Li, Chunguo Liu

Journal: Poult Sci

PubMed ID: 38878745

Doi: 10.1016/j.psj.2024.103907

Products & Services: PCR Cloning and Subcloning

Identification of a novel neurovirulence factor encoded by the cryptic orphan gene UL316 of herpes simplex virus 1

Authors: Akihisa Kato, Ryoji Iwasaki, Kousuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Tohru Natsume, Hideo Kusano, Shungo Adachi, Shuichi Kawano, Yasushi Kawaguchi

Journal: J Virol

PubMed ID: 38819171

Doi: 10.1128/jvi.00747-24

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Structural insights into the molecular mechanism of phytoplasma immunodominant membrane protein

Authors: Chang Yi Liu, Han Pin Cheng, Chan Pin Lin, Yi Ting Liao, Tzu Ping Ko, Shin Jen Lin, Shih Shun Lin, Hao Ching Wang

Journal: IUCrJ

PubMed ID: 38656311

Doi: 10.1107/S2052252524003075

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Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo

Authors: Anke Vermehren-Schmaedick, Myron Peto, Wendy Wagoner, Kami E Chiotti, Elizabeth Ramsey, Xiaoyan Wang, Shauna Rakshe, Jessica Minnier, Rosalie Sears, Paul Spellman, Shiuh-Wen Luoh

Journal: PLoS ONE

PubMed ID: 38722955

Doi: 10.1371/journal.pone.0302856

Products & Services: PCR Cloning and Subcloning

Imprinted lncRNA KCNQ1OT1 regulates CDKN1C expression through promoter binding and chromatin folding in pigs

Authors: Yongfeng Zhou, Hao Yu, Daoyu Zhang, Zhengzhu Wang, Qi Li, Xinglan An, Sheng Zhang, Ziyi Li

Journal: Gene

PubMed ID: 38772516

Doi: 10.1016/j.gene.2024.148590

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of phosphorylated small ORF-encoded peptides in Hep3B cells by LC/MS/MS

Authors: Mingbo Peng, Yutian Zhou, Cuihong Wan

Journal: J Proteomics

PubMed ID: 38823442

Doi: 10.1016/j.jprot.2024.105214

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A new strategy to generate nanobodies for the coumaphos based on the synthesized nanobody libraries

Authors: Ruyu Fang, Yingxue Li, Fei Liu, Yifan Liang, Yu Wang, Guohua Zhong, Zhenlin Xu, Bruce D Hammock, Hong Wang

Journal: Food Chem

PubMed ID: 38833869

Doi: 10.1016/j.foodchem.2024.139684

Production of VP3-only virus-like particles of Adeno-associated virus 2 in E coli cells

Authors: Chengyu Fu, Shruthi Gobbooru, Ashley T Martino, Woon-Kai Low

Journal: Protein Expr Purif

PubMed ID: 38754753

Doi: 10.1016/j.pep.2024.106502

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Identification and characterisation of novel CAR-T cells to target IL13Rα2 positive human glioma in vitro and in vivo

Authors: Pamela Leland, Heba Degheidy, Ashley Lea, Steven R Bauer, Raj K Puri, Bharat H Joshi

Journal: Clin Transl Med

PubMed ID: 38685487

Doi: 10.1002/ctm2.1664

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mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models

Authors: Xuesong Wang, Christopher A Cottrell, Xiaozhen Hu, Rashmi Ray, Maria Bottermann, Paula Maldonado Villavicencio, Yu Yan, Zhenfei Xie, John E Warner, Jordan Renae Ellis-Pugh, Oleksandr Kalyuzhniy, Alessia Liguori, Jordan R Willis, Sergey Menis, Sebastian Rämisch, Saman Eskandarzade, Michael Kubitz, Ryan Tingle Nicole Phelps, Bettina Groschel, Sunny Himansu, Andrea Carfi, Kathrin H Kirsch, Stephanie R Weldon, Usha Nair, William R Schief, Facundo D Batista

Journal: Science immunology

PubMed ID: 38753808

Doi: 10.1126/sciimmunol.adn0622

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Quercetin induces itaconic acid-mediated M1/M2 alveolar macrophages polarization in respiratory syncytial virus infection

Authors: Li An , Qianwen Zhai , Keyu Tao , Yingcai Xiong , Weiying Ou , Ziwei Yu , Xingyu Yang , Jianjian Ji , Mengjiang Lu

Journal: Phytomedicine

PubMed ID: 38797031

Doi: 10.1016/j.phymed.2024.155761

Products & Services: Proteins, Expression, Isolation and Analysis

Imaging the dynamics of messenger RNA with a bright and stable green fluorescent RNA

Authors: Fangting Zuo, Li Jiang, Ni Su, Yaqiang Zhang, Bingkun Bao, Limei Wang, Yajie Shi, Huimin Yang, Xinyi Huang, Ruilong Li, Qingmei Zeng, Zhengda Chen, Qiuning Lin, Yingping Zhuang, Yuzheng Zhao, Xianjun Chen, Linyong Zhu & Yi Yang

Journal: nature chemical biology

PubMed ID: 38783134

Doi: 10.1038/s41589-024-01629-x

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F Nucleatum enhances oral squamous cell carcinoma proliferation via E-cadherin/β-Catenin pathway

Authors: Zhengrui Li, Yuan Liu, Xufeng Huang, Qi Wang, Rao Fu, Xutao Wen, Ji'an Liu, Ling Zhang

Journal: BMC Oral Health

PubMed ID: 38698370

Doi: 10.1186/s12903-024-04252-3

Products & Services: Proteins, Expression, Isolation and Analysis

Immunogenicity Analysis and Identification of Potential T-Cell Epitopes in C129R Protein of African Swine Fever Virus

Authors: Wenzhu Zhai, Ying Huang, Yuheng He, Yuanyuan Chu, Chunhao Tao, Zhongbao Pang, Zhen Wang, Hongfei Zhu, Hong Jia

Journal: Microorganisms

PubMed ID: 38930438

Doi: 10.3390/microorganisms12061056

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Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM

Authors: Weicheng Li, Haoyun Yang, Kye Stachowski, Andrew S Norris, Katie Lichtenthal, Skyler Kelly, Paul Gollnick, Vicki H Wysocki, Mark P Foster

Journal: biorxiv

PubMed ID: 38746386

Doi: 10.1101/2024.05.02.592192

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Detection of SARS-CoV-2-Specific Secretory IgA and Neutralizing Antibodies in the Nasal Secretions of Exposed Seronegative Individuals

Authors: Jason S Chwa, Minjun Kim, Yesun Lee, Wesley A Cheng, Yunho Shin, Jaycee Jumarang, Jeffrey M Bender, Pia S Pannaraj

Journal: Viruses

PubMed ID: 38932145

Doi: 10.3390/v16060852

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TALEN-mediated homologous-recombination-based fibroin light chain in-fusion expression system in

Authors: Shihua Yu, Huoqing Zheng, Xiaogang Ye, Xiangping Dai, Xinqiu Wang, Shuo Zhao, Xiaoyan Dai, Boxiong Zhong

Journal: Front Bioeng Biotechnol

PubMed ID: 38832132

Doi: 10.3389/fbioe.2024.1399629

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LINE-1 retrotransposons contribute to mouse PV interneuron development

Authors: Gabriela O Bodea, Juan M Botto, Maria E Ferreiro, Francisco J Sanchez-Luque, Jose de Los Rios Barreda, Jay Rasmussen, Muhammed A Rahman, Laura R Fenlon, Natasha Jansz, Carolina Gubert, Patricia Gerdes, Liviu-Gabriel Bodea, Prabha Ajjikuttira, Darwin J Da Costa Guevara, Linda Cumner, Charles C Bell, Peter Kozulin, Victor Billon, Santiago Morell, Marie-Jeanne H C Kempen, Chloe J Love, Karabi Saha, Lucy M Palmer, Adam D Ewing, Dhanisha J Jhaveri, Sandra R Richardson, Anthony J Hannan, Geoffrey J Faulkner

Journal: Nat Neurosci

PubMed ID: 38773348

Doi: 10.1038/s41593-024-01650-2

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Identification of Fibrinogen as a Plasma Protein Binding Partner for Lecanemab Biosimilar IgG: Implications for Alzheimer's Disease Therapy

Authors: Jean-Pierre Bellier, Andrea Roman, Caitlyn Christiano, Juliana Au Anzai, Stephanie Moreno, Emily C Campbell, Lucas Godwin, Amy Li, Alan Chen, Sarah M Alan, Adriana Saba, Han Bin Yoo, Hyun-Sik Yang, Jasmeer P Chhatwal, Dennis J Selkoe, Lei Liu

Journal: biorxiv

PubMed ID: 38746192

Doi: 10.1101/2024.05.01.591892

Products & Services: Proteins, Expression, Isolation and Analysis

Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren's syndrome in mice by promoting TEC kinase degradation

Authors: Ya-Qi Yang, Yi-Jun Liu, Wen-Xuan Qiao, Wei Jin, Shun-Wei Zhu, Yu-Xi Yan, Qiong Luo, Qiang Xu

Journal: Acta Pharmacol Sin

PubMed ID: 38744938

Doi: 10.1038/s41401-024-01288-7

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A ferritin nanoparticle vaccine based on the hemagglutinin extracellular domain of swine influenza A (H1N1) virus elicits protective immune responses in mice and pigs

Authors: Pan Tang, Enhui Cui, Jinghua Cheng, Benqiang Li, Jie Tao, Ying Shi, Jiajie Jiao, Enqi Du, Jingyu Wang, Huili Liu

Journal: Front Immunol

PubMed ID: 38835763

Doi: 10.3389/fimmu.2024.1361323

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Library Screening, In Vivo Confirmation, and Structural and Bioinformatic Analysis of Pentapeptide Sequences as Substrates for Protein Farnesyltransferase

Authors: Garrett L Schey, Emily R Hildebrandt, You Wang, Safwan Diwan, Holly A Passetti, Gavin W Potts, Andrea M Sprague-Getsy, Ethan R Leoni, Taylor S Kuebler, Yuk Y Sham, James L Hougland, Lorena S Beese, Walter K Schmidt, Mark D Distefano

Journal: Int J Mol Sci

PubMed ID: 38791363

Doi: 10.3390/ijms25105324

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Exploring Syndecan-4 and MLP and Their Interaction in Primary Cardiomyocytes and H9c2 Cells

Authors: Thea Parsberg Støle, Marianne Lunde, Katja Gehmlich, Geir Christensen, William E Louch, Cathrine Rein Carlson

Journal: Cells

PubMed ID: 38891079

Doi: 10.3390/cells13110947

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The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and limits fibrosis by suppressing GPNMB-mediated TGF-β signaling

Authors: Muneera Vakayil, Aisha Y Madani, Maha V Agha, Yasser Majeed, Shahina Hayat, Shameem Yonuskunju, Yasmin Ali Mohamoud, Joel Malek, Karsten Suhre, Nayef A Mazloum

Journal: Sci Rep

PubMed ID: 38789534

Doi: 10.1038/s41598-024-62508-y

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Development of a nucleoside-modified mRNA vaccine against clade 2344b H5 highly pathogenic avian influenza virus

Authors: Colleen Furey, Gabrielle Scher, Naiqing Ye, Lisa Kercher, Jennifer DeBeauchamp, Jeri Carol Crumpton, Trushar Jeevan, Christopher Patton, John Franks, Adam Rubrum, Mohamad-Gabriel Alameh, Steven H Y Fan, Anthony T Phan, Christopher A Hunter, Richard J Webby, Drew Weissman, Scott E Hensley

Journal: Nat Commun

PubMed ID: 38782954

Doi: 10.1038/s41467-024-48555-z

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Automated characterization and analysis of expression compatibility between regulatory sequences and metabolic genes in

Authors: Xiao Wen, Jiawei Lin, Chunhe Yang, Ying Li, Haijiao Cheng, Ye Liu, Yue Zhang, Hongwu Ma, Yufeng Mao, Xiaoping Liao, Meng Wang

Journal: Synth Syst Biotechnol

PubMed ID: 38817827

Doi: 10.1016/j.synbio.2024.05.010

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Substrate Affinity Is Not Crucial for Therapeutic L-Asparaginases: Antileukemic Activity of Novel Bacterial Enzymes

Authors: Anna Ściuk, Kinga Wątor, Izabela Staroń, Paulina Worsztynowicz, Kinga Pokrywka, Joanna Sliwiak, Marta Kilichowska, Kamila Pietruszewska, Zofia Mazurek, Anna Skalniak, Krzysztof Lewandowski, Mariusz Jaskolski, Joanna I Loch, Marcin Surmiak

Journal: Molecules

PubMed ID: 38792133

Doi: 10.3390/molecules29102272

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Biophysical insights into the dimer formation of human Sirtuin 2

Authors: Noa Suzuki, Tsuyoshi Konuma, Takahisa Ikegami, Satoko Akashi

Journal: Protein Sci

PubMed ID: 38647411

Doi: 10.1002/pro.4994

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Construction and in vitro characterisation of virus-vectored immunocontraceptive candidates derived from felid alphaherpesvirus 1

Authors: Ellen Cottingham, Thurid Johnstone, Paola K Vaz, Carol A Hartley, Joanne M Devlin

Journal: Vaccine

PubMed ID: 38824082

Doi: 10.1016/j.vaccine.2024.05.047

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Combined effect of SAR-endolysin LysKpV475 with polymyxin B and bacteriophage phSE-5

Authors: Marco Gontijo, Mateus Pereira Teles, Hugo Martins Correia, Genesy Pérez Jorge, Isabella Carolina Rodrigues Santos Goes, Anthony Jhoao Fasabi Flores, Márcia Braz, Lucas de Moraes Ceseti, Priscila Zonzini Ramos, Ivan Rosa E Silva, Pedro Marcus Pereira Vidigal, Jörg Kobarg, Rafael Miguez Couñago, Cristina Elisa Alvarez-Martinez, Carla Pereira, Carmen S R Freire, Adelaide Almeida, Marcelo Brocchi

Journal: Microbiology (Reading)

PubMed ID: 38739436

Doi: 10.1099/mic.0.001462

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A Piecewise Design Approach to Engineering a Miniature ACE2 Mimic to Bind SARS-CoV-2

Authors: Yashavantha L Vishweshwaraiah, Brianna Hnath, Jian Wang, Morgan Chandler, Arnab Mukherjee, Neela H Yennawar, Squire J Booker, Kirill A Afonin, Nikolay V Dokholyan

Journal: ACS Appl Bio Mater

PubMed ID: 38700999

Doi: 10.1021/acsabm.4c00222

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Novel Multi-Antigen Orf-Virus-Derived Vaccine Elicits Protective Anti-SARS-CoV-2 Response in Monovalent and Bivalent Formats

Authors: Dominique Julien Burri, Louis Renz, Melanie Mueller, Felix Pagallies, Ute Klinkhardt, Ralf Amann, Madiha Derouazi

Journal: Vaccines (Basel)

PubMed ID: 38793740

Doi: 10.3390/vaccines12050490

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Citrus psorosis virus 24K protein inhibits the processing of miRNA precursors by interacting with components of the biogenesis machinery

Authors: Facundo E Marmisolle, María B Borniego, Damián A Cambiagno, Lucia Gonzalo, María L García, Pablo A Manavella, Carmen Hernández, Carina A Reyes

Journal: Microbiol Spectr

PubMed ID: 38785434

Doi: 10.1128/spectrum.03513-23

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A fluorescence anisotropy-based competition assay to identify inhibitors against ricin and Shiga toxin ribosome interactions

Authors: Arkajyoti Dutta, Zoltan Szekely, Hakan Guven, Xiao-Ping Li, John E McLaughlin, Nilgun E Tumer

Journal: Anal Biochem

PubMed ID: 38825159

Doi: 10.1016/j.ab.2024.115580

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Multifunctional bispecific nanovesicles targeting SLAMF7 trigger potent antitumor immunity

Authors: Manman Zhu, Yongjian Wu, Tianchuan Zhu, Jian Chen, Zhenxing Chen, Hanxi Ding, Siyi Tan, Jianzhong He, Qi Zeng, Xi Huang

Journal: Cancer Immunol Res

PubMed ID: 38819238

Doi: 10.1158/2326-6066.CIR-23-1102

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Anti-HIV Humoral Response Induced by Different Anti-Idiotype Antibody Formats: An In Silico and In Vivo Approach

Authors: Valeria Caputo, Ilaria Negri, Louiza Moudoud, Martina Libera, Luigi Bonizzi, Massimo Clementi, Roberta Antonia Diotti

Journal: Int J Mol Sci

PubMed ID: 38891926

Doi: 10.3390/ijms25115737

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Cross-reactivity of hantavirus antibodies after immunization with PUUV antigens

Authors: Layaly Shkair, Diksha Sharma, Shaimaa Hamza, Ekaterina Garanina, Venara Shakirova, Ilsiyar Khaertynova, Maria Markelova, Vera Pavelkina, Albert Rizvanov, Svetlana Khaiboullina, Manoj Baranwal, Ekaterina Martynova

Journal: Biotechnol Appl Biochem

PubMed ID: 38779849

Doi: 10.1002/bab.2604

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Elucidation of the Catalytic Sequence of Dihydroorotate Dehydrogenase B from : Evidence for Accumulation of a Flavin Bisemiquinone State in Catalysis

Authors: Corine O Smith, Graham R Moran

Journal: Biochemistry

PubMed ID: 38691339

Doi: 10.1021/acs.biochem.4c00025

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Radiation-primed TGF-β trapping by engineered extracellular vesicles for targeted glioblastoma therapy

Authors: Ruyu Liang, Hongyu Lu, Haifeng Zhu, Gaofeng Liang, Junxia Zhang, Jun Gao, Tian Tian

Journal: J Control Release

PubMed ID: 38740092

Doi: 10.1016/j.jconrel.2024.05.022

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Delivery of endolysin across outer membrane of Gram-negative bacteria using translocation domain of botulinum neurotoxin

Authors: Wonbeom Park, Myungseo Park, Jihwan Chun, Jaehyeon Hwang, Suhyun Kim, Nayoon Choi, Soo Min Kim, SeungJoo Kim, Sangwon Jung, Kwan Soo Ko, Dae-Hyuk Kweon

Journal: Int J Antimicrob Agents

PubMed ID: 38795926

Doi: 10.1016/j.ijantimicag.2024.107216

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Transcriptome Analysis Reveals the Induction of Apoptosis-Related Genes by a Monoclonal Antibody against a New Epitope of CD99 on T-Acute Lymphoblastic Leukemia

Authors: Nuchjira Takheaw, Kamonporn Kotemul, Ratthakorn Chaiwut, Supansa Pata, Witida Laopajon, Kuntalee Rangnoi, Montarop Yamabhai, Watchara Kasinrerk

Journal: Antibodies (Basel)

PubMed ID: 38804310

Doi: 10.3390/antib13020042

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Development of a Plant-Expressed Subunit Vaccine against Brucellosis

Authors: Daria A Rutkowska, Lissinda H Du Plessis, Essa Suleman, Martha M O'Kennedy, Deepak B Thimiri Govinda Raj, Yolandy Lemmer

Journal: Microorganisms

PubMed ID: 38930429

Doi: 10.3390/microorganisms12061047

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Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations

Authors: Jeannette L Tenthorey, Serena Del Banco, Ishrak Ramzan, Hayley Klingenberg, Chang Liu, Michael Emerman, Harmit S Malik

Journal: biorxiv

PubMed ID: 38765965

Doi: 10.1101/2024.05.07.592993

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Analysis of the molecular basis for the non-amylolytic and non-proteolytic nature of Aspergillus vadensis CBS 113365

Authors: Dujuan Liu, Sandra Garrigues, Helena Culleton, Vincent A McKie, Ronald P de Vries

Journal: N Biotechnol

PubMed ID: 38697469

Doi: 10.1016/j.nbt.2024.04.003

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Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis

Authors: Zhixin Ma, Yu Sun, Yang Yu, Wenjun Xiao, Zhijie Xiao, Tianyu Zhong, Xi Xiang, Zhigang Li

Journal: Cell Commun Signal

PubMed ID: 38802814

Doi: 10.1186/s12964-024-01669-9

Scanning mutagenesis of the voltage-gated sodium channel Na12 using base editing

Authors: Juan Lorenzo B Pablo, Savannah L Cornett, Lei A Wang, Sooyeon Jo, Tobias Brünger, Nikita Budnik, Mudra Hegde, Jean-Marc DeKeyser, Christopher H Thompson, John G Doench, Dennis Lal, Alfred L George, Jen Q Pan

Journal: Cell Rep

PubMed ID: 38823014

Doi: 10.1016/j.celrep.2024.114327

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Safety, immunogenicity and efficacy of the self-amplifying mRNA ARCT-154 COVID-19 vaccine: pooled phase 1, 2, 3a and 3b randomized, controlled trials

Authors: Nhân Thị Hồ, Steven G Hughes, Van Thanh Ta, Lân Trọng Phan, Quyết Đỗ, Thượng Vũ Nguyễn, Anh Thị Văn Phạm, Mai Thị Ngọc Đặng, Lượng Viết Nguyễn, Quang Vinh Trịnh, Hùng Ngọc Phạm, Mến Văn Chử, Toàn Trọng Nguyễn, Quang Chấn Lương, Vy Thị Tường Lê, Thắng Văn Nguyễn, Lý-Thi-Lê Trần, Anh Thi Van Luu, Anh Ngoc Nguyen, Nhung-Thi-Hong Nguyen, Hai-Son Vu, Jonathan M Edelman, Suezanne Parker, Brian Sullivan, Sean Sullivan, Qian Ruan, Brenda Clemente, Brian Luk, Kelly Lindert, Dina Berdieva, Kat Murphy, Rose Sekulovich, Benjamin Greener, Igor Smolenov, Pad Chivukula, Vân Thu Nguyễn, Xuan-Hung Nguyen

Journal: Nat Commun

PubMed ID: 38744844

Doi: 10.1038/s41467-024-47905-1

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The pioneer transcription factor Zelda facilitates the exit from regeneration and restoration of patterning in

Authors: Anish Bose, Keaton Schuster, Chandril Kodali, Surabhi Sonam, Rachel Smith-Bolton

Journal: biorxiv

PubMed ID: 38854062

Doi: 10.1101/2024.05.30.596672

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Optimization of quenched fluorescent peptide substrates of SARS-CoV-2 3CL main protease (Mpro) from proteomic identification of P6-P6' active site specificity

Authors: Hugo Cesar Ramos de Jesus, Nestor Solis, Yoan Machado, Isabel Pablos, Peter A Bell, Reinhild Kappelhoff, Peter M Grin, Carlos A Sorgi, Georgina S Butler, Christopher M Overall

Journal: J Virol

PubMed ID: 38742901

Doi: 10.1128/jvi.00049-24

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How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism

Authors: David Eisenberg, Ke Hou, Peng Ge, Michael Sawaya, Joshua Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli Feigon

Journal: Res Sq

PubMed ID: 38766197

Doi: 10.21203/rs.3.rs-4152095/v1

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A vector system for single and tandem expression of cloned genes and multi-colour fluorescent tagging in

Authors: Solenne Ithurbide, Roshali T de Silva, Hannah J Brown, Vinaya Shinde, Iain G Duggin

Journal: Microbiology (Reading)

PubMed ID: 38787390

Doi: 10.1099/mic.0.001461

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Plasmodium falciparum Glutamic Acid-Rich Protein-Independent Polyclonal Antibodies Inhibit Malaria Parasite Growth in Human Erythrocytes

Authors: Christopher J Schwake, Rachel M Krueger, Toshihiko Hanada, Athar H Chishti

Journal: J Infect Dis

PubMed ID: 38298126

Doi: 10.1093/infdis/jiae050

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Poc1 bridges basal body inner junctions to promote triplet microtubule integrity and connections

Authors: Marisa D Ruehle, Sam Li, David A Agard, Chad G Pearson

Journal: J Cell Biol

PubMed ID: 38743010

Doi: 10.1083/jcb.202311104

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A potent Henipavirus cross-neutralizing antibody reveals a dynamic fusion-triggering pattern of the G-tetramer

Authors: Pengfei Fan, Mengmeng Sun, Xinghai Zhang, Huajun Zhang, Yujiao Liu, Yanfeng Yao, Ming Li, Ting Fang, Bingjie Sun, Zhengshan Chen, Xiangyang Chi, Li Chen, Cheng Peng, Zhen Chen, Guanying Zhang, Yi Ren, Zixuan Liu, Yaohui Li, Jianmin Li, Entao Li, Wuxiang Guan, Shanshan Li, Rui Gong, Kaiming Zhang, …Sandra Chiu

Journal: Nat Commun

PubMed ID: 38773072

Doi: 10.1038/s41467-024-48601-w

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CRISPR/Cas9-Mediated Knockout of the Lycopene ε-Cyclase for Efficient Astaxanthin Production in the Green Microalga

Authors: Jacob Sebastian Kneip, Niklas Kniepkamp, Junhwan Jang, Maria Grazia Mortaro, EonSeon Jin, Olaf Kruse, Thomas Baier

Journal: Plants (Basel)

PubMed ID: 38794462

Doi: 10.3390/plants13101393

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Structure and genome editing of type I-B CRISPR-Cas

Authors: Meiling Lu, Chenlin Yu, Yuwen Zhang, Wenjun Ju, Zhi Ye, Chenyang Hua, Jinze Mao, Chunyi Hu, Zhenhuang Yang & Yibei Xiao

Journal: Nat Commun

PubMed ID: 38750051

Doi: 10.1038/s41467-024-48598-2

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Amplifiable protein identification via residue-resolved barcoding and composition code counting

Authors: Weiming Guo , Yuan Liu , Yu Han , Huan Tang , Xinyuan Fan , Chu Wang , Peng R Chen

Journal: National Science Review

PubMed ID: 39055168

Doi: 10.1093/nsr/nwae183

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A converged ubiquitin‐proteasome pathway for the degradation of TOC and TOM tail‐anchored receptors

Authors: Meijing Yang , Shuai Chen , Shey-Li Lim , Lang Yang , Jia Yi Zhong , Koon Chuen Chan , Zhizhu Zhao , Kam-Bo Wong , Junqi Wang , Boon Leong Lim

Journal: Journal of integrative plant biology

PubMed ID: 38501483

Doi: doi.org/10.1111/jipb.13645

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Single-molecule assay guided crRNA optimization enhances specific microRNA detection by CRISPR-Cas12a

Authors: Kaizhao Chen, Wenjun Sun, Mingtian Zhong, Jiaqi Xie, Yongkun Huo, Xiuqi Lu, Ziting Chen, Bo Sun, Xingxu Huang, Xinjie Wang， Ming Liu , Xiaodong Ma, Peixiang Ma

Journal: Sensors and Actuators B: Chemical

Doi: 10.1016/j.snb.2024.135389

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A Customized Biohybrid presenting Cascade Responses to Tumor Microenvironment

Authors: Feiyu Li, Peipei Zhu, Bingzhu Zheng, Zijie Lu, Chao Fang, Yike Fu, Xiang Li

Journal: Adv Mater

PubMed ID: 38723206

Doi: 10.1002/adma.202404901

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Thalidomide derivatives degrade BCL-2 by reprogramming the binding surface of CRBN

Authors: Jianhui Wang (王建辉) , Marcel Heinz, Kang Han (韩康), Varun J. Shah, Sebastian Hasselbeck, Martin P. Schwalm, Rajeshwari Rathore, Gerhard Hummer, Jun Zhou (周俊), Ivan Dikic, Xinlai Cheng (承辛来)

Journal: Cell Reports Physical Science

Doi: doi.org/10.1016/j.xcrp.2024.101960

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