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A humanised ACE2, TMPRSS2, and FCGRT mouse model reveals the protective efficacy of anti-receptor binding domain antibodies elicited by SARS-CoV-2 hybrid immunity

Authors: Fernanda Ana-Sosa-Batiz; Shailendra Kumar Verma; Norazizah Shafee; Robyn Miller; Chris Conner; Kathryn M. Hastie; Julia Timis; Erin Maule; Michael N. Nguyen; Linda Tran; Krithik Varghese; Henry Madany; Audrey Elizabeth Street; Michelle Zandonatti; Meng Ling Moi; Kurt Jarnagin; David R. Webb; Erica Ollmann Saphire; Kenneth Kim; Sujan Shresta

Journal: EBioMedicine

PubMed ID: 40020261

Doi: 10.1016/j.ebiom.2025.105619

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Astragalus Polysaccharides Ameliorate Diabetic Bladder Dysfunction via Normalization of Neuromuscular Conduction

Authors: Shaochan Liang, Siyuan Xu, Shenglian Ye, Lang Liang, Hongliang Li, Jiaye Liu, Yao Zhang, Feng Zou, Xiaodan Liang, Bo Tan, Hongying Cao

Journal: J Agric Food Chem

PubMed ID: 40032633

Doi: 10.1021/acs.jafc.4c11577

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The structure and function of the ghrelin receptor coding for drug actions

Authors: Yuki Shiimura, Dohyun Im, Ryosuke Tany, Hidetsugu Asada, Ryoji Kise, Eon Kurumiya, Hideko Wakasugi-Masuho, Satoshi Yasuda, Kazuma Matsui, Jun-Ichi Kishikawa, Takayuki Kato, Takeshi Murata, Masayasu Kojima, So Iwata, Ikuo Masuho

Journal: Nat Struct Mol Biol

PubMed ID: 39833471

Doi: 39833471

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Expediting Genome Synthesis of Corynebacterium glutamicum with An Artificial Chromosome Vector

Authors: Zhanhua Zhang, Peixiong Hong, Zebin Li, Baitao Li, Tai Chen, Yue Shen, Xiaofeng Yang, Yanrui Ye, Yun Wang, Zhanglin Lin

Journal: Trends Biotechnol

PubMed ID: 40155267

Doi: 10.1016/j.tibtech.2025.02.019

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The E3 ubiquitin ligase SlATL2 suppresses tomato immunity by promoting SlCSN5a degradation during Pseudomonas syringae pv. tomato DC3000 infection

Authors: Yujie Dai, Xiaodan Li, Yeling He, Liya Zhu, Yan Bi, Fengming Song, Dayong Li

Journal: Horticulture research

PubMed ID: 40303438

Doi: 10.1093/hr/uhaf078

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Antigen-presenting cancer associated fibroblasts enhance antitumor immunity and predict immunotherapy response

Authors: Junquan Song, Rongyuan Wei, Chenchen Liu, Zhenxiong Zhao, Xuanjun Liu, Yanong Wang, Fenglin Liu, Xiaowen Liu

Journal: Nature Communications

PubMed ID: 40038297

Doi: 10.1038/s41467-025-57465-7

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Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin

Authors: Jia Li, Lei Cao, Yaqian Zhao, Jinghan Shen, Lei Wang, Mingfeng Feng, Min Zhu, Yonghao Ye, Richard Kormelink, Xiaorong Tao, Xiangxi Wang

Journal: Nat Plants

PubMed ID: 40044941

Doi: 10.1038/s41477-025-01940-y

Oxytocin induces embryonic diapause

Authors: Jessica L Minder, Sarah B Winokur, Janaye Stephens, Jie Tong, Naomi L Cassel, Luisa Schuster, Habon A Issa, Michael Cammer, Latika Khatri, Gaia Moisan, Maria Alvarado-Torres, Orlando Aristizábal, Youssef Z Wadghiri, Sang Yong Kim, Silvana Valtcheva, Catherine Pei-Ju Lu, Moses V Chao, Robert C Froemke

Journal: SCIENCE ADVANCES

PubMed ID: 40043121

Doi: 10.1126/sciadv.adt1763

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Monitoring mRNA vaccine antigen expression in vivo using PET/CT

Authors: Gabrielle S Blizard, Garima Dwivedi, Yi-Gen Pan, Catherine Hou, Jean M Etersque, Hooda Said, Anik Chevrier, Marc Lavertu, Houping Ni, Benjamin Davis, Ying Tam, Quy Cao, Robert H Mach, Drew Weissman, Mohamad-Gabriel Alameh, Mark A Sellmyer

Journal: Nature Communications

PubMed ID: 40044669

Doi: 10.1038/s41467-025-57446-w

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The conductance of KCNQ2 and its pathogenic variants is determined by individual subunit gating

Authors: Andy Hinojo-Perez, Jodene Eldstrom, Ying Dou, Allan Marinho-Alcara, Michaela A Edmond, Alicia de la Cruz, Marta E Perez Rodriguez, Maykelis Diaz-Solares, Derek M Dykxhoorn, David Fedida, Rene Barro-Soria

Journal: SCIENCE ADVANCES

PubMed ID: 40043113

Doi: 10.1126/sciadv.adr7012

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Optimization of Lipid Nanoparticles with Robust Efficiency for the Delivery of Protein Therapeutics to Augment Cancer Immunotherapy

Authors: Lanfang Ren, Zeda Zhao, Yuqing Chao, Panting Yu, Zhoufang Mei, Bing Du, Yiyun Cheng

Journal: Advanced Science

PubMed ID: 40056044

Doi: 10.1002/advs.202500844

The structural basis for the human procollagen lysine hydroxylation and dual-glycosylation

Authors: Junjiang Peng, Wenguo Li, Deqiang Yao, Ying Xia, Qian Wang, Yan Cai, Shaobai Li, Mi Cao, Yafeng Shen, Peixiang Ma, Rijing Liao, Jie Zhao, An Qin, Yu Cao

Journal: Nature Communications

PubMed ID: 40069201

Doi: 10.1038/s41467-025-57768-9

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USP7 V517F mutation as a mechanism of inhibitor resistance

Authors: Yu-Ling Miao, Fengying Fan, Yong-Jun Cheng, Li Jia, Shan-Shan Song, Xia-Juan Huan, Xu-Bin Bao, Jian Ding, Xuekui Yu, Jin-Xue He

Journal: Nature Communications

PubMed ID: 40087304

Doi: 10.1038/s41467-025-56981-w

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Authors: Jingjing Wang, Yong Ma, Zimu Li, Hang Yuan, Banghui Liu, Zexuan Li, Mengzhen Su, Gul Habib, Yutong Liu, Lutang Fu, Peiyi Wang, Mei Li, Jun He, Jing Chen, Peng Zhou, Zhengli Shi, Xinwen Chen, Xiaoli Xiong

Journal: SCIENCE ADVANCES

PubMed ID: 40085715

Doi: 10.1126/sciadv.adr8772

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Developing Quorum Sensing-Based Collaborative Dynamic Control System in Halomonas TD01

Authors: Yi-Na Lin, Yu-Xi Li, Ye Zheng, Yi-Hao Deng, Kai-Xuan Liu, Yue Gan, Hao Li, Jun Wang, Jia-Wen Peng, Rui-Zhe Deng, Huai-Ming Wang, Hui Wang, Jian-Wen Ye

Journal: Advanced Science

PubMed ID: 40091435

Doi: 10.1002/advs.202408083

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Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma

Authors: Hao Shi, Yajie Yang, Jiwei Gao, Satendra Kumar, Hong Xie, Ziqing Chen, Jiawen Lyu, Harri Sihto, Virve Koljonen, Silvia Vega-Rubin-de-Celis, Vladana Vukojevic, Filip Farnebo, Viveca Björnhagen, Anders Höög, C Christofer Juhlin, Linkiat Lee, Malin Wickström, Jürgen C Becker, John Inge Johnsen, Catharina Larsson, Weng-Onn Lui

Journal: Nature Communications

PubMed ID: 40108758

Doi: 10.1080/15548627.2025.2477385

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Acute diacylglycerol production activates critical membrane-shaping proteins leading to mitochondrial tubulation and fission

Authors: Joshua G Pemberton, Krishnendu Roy, Yeun Ju Kim, Tara D Fischer, Vijay Joshi, Elizabeth Ferrer, Richard J Youle, Thomas J Pucadyil, Tamas Balla

Journal: Nature Communications

PubMed ID: 40102394

Doi: 10.1038/s41467-025-57439-9

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Reprogramming yeast metabolism for customized starch-rich micro-grain through low-carbon microbial manufacturing

Authors: Zhihui Shi, Zhaoyu Xu, Weihe Rong, Hongbing Sun, Hongyi Zhou, Qianqian Yuan, Aixuan Xiao, Hongfei Ma, Tao Cai, Guokun Wang, Yanhe Ma

Journal: Nature Communications

PubMed ID: 40118900

Doi: 10.1038/s41467-025-58067-z

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Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome

Authors: Jessica C Hargarten, Kenneth Ssebambulidde, Seher H Anjum, Malcolm J Vaughan, Jintao Xu, Anutosh Ganguly, Brittany Dulek, Francisco Otaizo-Carrasquero, Brian Song, Sijia Tao, Yoon-Dong Park, Terri L Scott, Tracey-Ann Höltermann, Raymond F Schinazi, Prashant Chittiboina, Bridgette Jeanne Billioux, Dima A Hammoud, Michal A Olszewski, Peter R Williamson

Journal: SCIENCE ADVANCES

PubMed ID: 40117367

Doi: 10.1126/sciadv.adi9885

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Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator

Authors: Demeng Sun, Xiang Li, Qingning Yuan, Yuanxia Wang, Pan Shi, Huanhuan Zhang, Tao Wang, Wenjing Sun, Shenglong Ling, Yuanchun Liu, Jinglin Lai, Wenqin Xie, Wanchao Yin, Lei Liu, H. Eric Xu, Changlin Tian

Journal: Cell Res

PubMed ID: 40118988

Doi: doi.org/10.1038/s41422-025-01095-7

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A Functional 3D Biomimetic Osteon Accelerates Bone Regeneration

Authors: Chenxu Zhu, Zexi Li, Xubin Qiu, Baizhen Zhao, Huan Wang, Lijie Wang, Ming Zhuang, Jinbo Liu, Fengxuan Han, Bin Li

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202500603

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Enhancing the Anticancer Activity of a Carcinoma-Directed Peptide–HLA-I Fusion Protein by Armoring with Mutein IFNα

Authors: Douwe Freerk Samplonius , Anne Paulien van Wijngaarden , Lisanne Koll , Xiurong Ke , Wijnand Helfrich

Journal: Int J Mol Sci

PubMed ID: 40243928

Doi: ijms26073178

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GLP1 alleviates oleic acid-propelled lipocalin-2 generation by tumor-infiltrating CD8+ T cells to reduce polymorphonuclear MDSC recruitment and enhances viral immunotherapy in pancreatic cancer

Authors: Jingyi Wu, Peng Qian, Yifeng Han, Chuning Xu, Mao Xia, Ping Zhan, Jiwu Wei, Jie Dong

Journal: Cellular & molecular immunology

PubMed ID: 39910336

Doi: 10.1038/s41423-025-01260-3

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Integrative in silico and biochemical analyses demonstrate direct Arl3-mediated ODA16 release from the intraflagellar transport machinery

Authors: Jiaolong Wang, Rune T Kidmose, Niels Boegholm, Nevin K Zacharia, Mads B Thomsen, Anni Christensen, Tara Malik, Karl Lechtreck, Esben Lorentzen

Journal: The Journal of Biological Chemistry

PubMed ID: 39880089

Doi: 10.1016/j.jbc.2025.108237

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Cell-autonomous innate immunity by proteasome-derived defence peptides

Authors: Karin Goldberg, Arseniy Lobov, Paola Antonello, Merav D Shmueli, Idan Yakir, Tal Weizman, Adi Ulman, Daoud Sheban, Einav Laser, Matthias P Kramer, Ronen Shteinvil, Guoyun Chen, Angham Ibraheem, Vera Sysoeva, Vered Fishbain-Yoskovitz, Gayatree Mohapatra, Anat Abramov, Sandy Shimshi, Kseniia Ogneva, Madhurima Nandy, Sivan Amidror, Hadar Bootz-Maoz, Shanny H Kuo, Nili Dezorella, Assaf Kacen, Aaron Javitt, Gee W Lau, Nissan Yissachar, Zvi Hayouka, Yifat Merbl

Journal: Nature

PubMed ID: 40044870

Doi: 10.1038/s41586-025-08615-w

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Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody

Authors: Susanne H D Ständer, Cyril F Reboul, Sarah N Le, Daniel E Williams, Peter G Chandler, Mauricio G S Costa, David E Hoke, John D T Jimma, James Fodor, Gustavo Fenalti, Stuart I Mannering, Benjamin T Porebski, Peter Schofield, Daniel Christ, Malcolm Buckle, Sheena McGowan, Dominika Elmlund, Kasper D Rand, Ashley M Buckle

Journal: Nature Communications

PubMed ID: 40055307

Doi: 10.1038/s41467-025-57492-4

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Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae from the blood circulation of mice

Authors: Haoran An, Yijia Huang, Zhifeng Zhao, Kunpeng Li, Jingjing Meng, Xueting Huang, Xianbin Tian, Hongyu Zhou, Jiamin Wu, Qionghai Dai, Jing-Ren Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 40073120

Doi: 10.1126/sciadv.adq6399

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PNPLA6 regulates retinal homeostasis by choline through phospholipid turnover

Authors: Takashi Ono, Yoshitaka Taketomi, Takayoshi Higashi, Hiroyasu Sato, Chika Mochizuki-Ono, Yuki Nagasaki, Takashi Ueta, Takashi Miyai, Suzumi M Tokuoka, Yoshiya Oda, Yasumasa Nishito, Tomio Ono, Choji Taya, Satoru Arata, Sumiko Watanabe, Tomoyoshi Soga, Tetsuya Hirabayashi, Makoto Aihara, Makoto Murakami

Journal: Nature Communications

PubMed ID: 40082403

Doi: 10.1038/s41467-025-57402-8

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A CPC-shelterin-BTR axis regulates mitotic telomere deprotection

Authors: Diana Romero-Zamora, Samuel Rogers, Ronnie Ren Jie Low, Scott G Page, Blake J E Lane, Shunya Kosaka, Andrew B Robinson, Lucy French, Noa Lamm, Fuyuki Ishikawa, Makoto T Hayashi, Anthony J Cesare

Journal: Nature Communications

PubMed ID: 40097392

Doi: 10.1038/s41467-025-57456-8

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FGF2 Mediated USP42-PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Authors: Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li

Journal: Advanced Science

PubMed ID: 40091484

Doi: 10.1002/advs.202408724

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Orally delivered toxin–binding protein protects against diarrhoea in a murine cholera model

Authors: Marcus Petersson, Franz G Zingl, Everardo Rodriguez-Rodriguez, Jakob K H Rendsvig, Heidi Heinsøe, Emma Wenzel Arendrup, Natalia Mojica, Dario Segura Peña, Nikolina Sekulić, Ute Krengel, Monica L Fernández-Quintero, Timothy P Jenkins, Lone Gram, Matthew K Waldor, Andreas H Laustsen, Sandra Wingaard Thrane

Journal: Nature Communications

PubMed ID: 40108169

Doi: 10.1038/s41467-025-57945-w

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Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining

Authors: Yan Wang, Fuyuan Shen, Chen Zhao, Jiali Li, Wen Wang, Yamu Li, Jia Gan, Haojian Zhang, Xuefeng Chen, Qiang Chen, Fangyu Wang, Ying Liu, Yan Zhou

Journal: Nucleic Acids Res

PubMed ID: 40114375

Doi: 10.1093/nar/gkaf200

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Transport and InsP8 gating mechanisms of the human inorganic phosphate exporter XPR1

Authors: Qinyu Zhu, Madeleine F Yaggi, Nikolaus Jork, Henning J Jessen, Melinda M Diver

Journal: Nature Communications

PubMed ID: 40113814

Doi: 10.1038/s41467-025-58076-y

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Machine Learning-Aided Identification of Fecal Extracellular Vesicle microRNA Signatures for Noninvasive Detection of Colorectal Cancer

Authors: Zhaowei Zhang, Xuyang Liu, Chuanyue Peng, Rui Du, Xiaoqin Hong, Jia Xu, Jiaming Chen, Xiaomin Li, Yujing Tang, Yuwei Li, Yang Liu, Chen Xu, Dingbin Liu

Journal: ACS Nano

PubMed ID: 40033785

Doi: 10.1021/acsnano.4c16698

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GPR132 regulates the function of NK cells through the Gαs/CSK/ZAP70/NF-κB signaling pathway as a potential immune checkpoint

Authors: Xinhui Hui, Min Xue, Yaojun Ren, Yiran Chen, Xuenan Chen, Muhammad Asad Farooq, Yuzhou Ji, Weirong Zhan, Yunhe Huang, Bingtan Du, Jie Yao, Yixin Duan, Wenzheng Jiang

Journal: Sci Adv

PubMed ID: 40043109

Doi: doi/10.1126/sciadv.adr9395

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Manganese-Driven Plasmid Nanofibers Formed In Situ for Cancer Gene Delivery and Metalloimmunotherapy

Authors: Jiexin Li, Ruiqi Yang, Chen Zhang, Jonathan F Lovell, Yumiao Zhang

Journal: J Am Chem Soc

PubMed ID: 40065259

Doi: 10.1021/jacs.4c18511

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Meiotic crossovers revealed by differential visualization of homologous chromosomes using enhanced haplotype oligo-painting in cucumber

Authors: Yafeng Wu，Zixuan Chen，Fengxiang Chen，Juan Su，Jianyu Han，Songqin Liu

Journal: Plant Biotechnol J

PubMed ID: 39661709

Doi: 10.1111/pbi.14546

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Examining the Role of Threonine Phosphorylation in Ubiquitin’s Function Using Chemical Protein Synthesis

Authors: Bingji Wang, Chuntong Li, Fangyu Zhao, Luyu Shi, Xu Li, Yijie Liu, Shuzhe Sun, Ligong Yuan, Maoshen Sun, Yingyue Zhang, Jing Shi, Lu-Jun Liang

Journal: JACS Au

Doi: doi/10.1021/jacsau.5c00067

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Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants

Authors: Shouya Feng, Matthew C Wierzbowski, Katja Hrovat-Schaale, Andreas Dumortier, Yaoyuan Zhang, Maria Zyulina, Paul J Baker, Thomas Reygaerts, Annemarie Steiner, Dominic De Nardo, Dhanya Lakshmi Narayanan, Florian Milhavet, Alberto Pinzon-Charry, Juan Ignacio Arostegui, Raju P Khubchandani, Matthias Geyer, Guilaine Boursier, Seth L Masters

Journal: nature immunology

PubMed ID: 39930093

Doi: 10.1038/s41590-025-02088-9

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FLT1 and other candidate fetal haemoglobin modifying loci in sickle cell disease in African ancestries

Authors: Ambroise Wonkam, Kevin Esoh, Rachel M Levine, Valentina Josiane Ngo Bitoungui, Khuthala Mnika, Nikitha Nimmagadda, Erin A D Dempsey, Siana Nkya, Raphael Z Sangeda, Victoria Nembaware, Jack Morrice, Fujr Osman, Michael A Beer, Julie Makani, Nicola Mulder, Guillaume Lettre, Martin H Steinberg, Rachel Latanich, James F Casella, Daiana Drehmer, Dan E Arking, Emile R Chimusa, Jonathan S Yen, Gregory A Newby, Stylianos E Antonarakis

Journal: Nature Communications

PubMed ID: 40025045

Doi: 10.1038/s41467-025-57413-5

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Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

Authors: Liora S Katz, Emira J Visser, Kathrin F Plitzko, Marloes A M Pennings, Peter J Cossar, Isabelle L Tse, Markus Kaiser, Luc Brunsveld, Christian Ottmann, Donald K Scott

Journal: Nature Communications

PubMed ID: 40025013

Doi: 10.1038/s41467-025-57241-7

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Blockade of ZMIZ1-GATA4 Axis Regulation Restores Youthfulness to Aged Cartilage

Authors: Jiho Nam, Hyunmin Woo, Jihye Yang, Seok Jung Kim, Kwang Pyo Lee, Ji Hoon Yu, Tae Joo Park, Seong-Il Eyun, Siyoung Yang

Journal: Advanced Science

PubMed ID: 40040621

Doi: 10.1002/advs.202404311

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Structures of complete HIV-1 TAR RNA portray a dynamic platform poised for protein binding and structural remodeling

Authors: Charles Bou-Nader, Katie A Link, Krishna C Suddala, Jay R Knutson, Jinwei Zhang

Journal: Nature Communications

PubMed ID: 40050622

Doi: 10.1038/s41467-025-57519-w

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Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits

Authors: Loϊc Binan, Aiping Jiang, Serwah A Danquah, Vera Valakh, Brooke Simonton, Jon Bezney, Robert T Manguso, Kathleen B Yates, Ralda Nehme, Brian Cleary, Samouil L Farhi

Journal: Cell

PubMed ID: 40081369

Doi: 10.1016/j.cell.2025.02.012

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Bacterial Hachiman complex executes DNA cleavage for antiphage defense

Authors: Yongqing Cui, Zhikang Dai, Yufei Ouyang, Chunyang Fu, Yanjing Wang, Xueting Chen, Kaiyue Yang, Shuyue Zheng, Wenwen Wang, Pan Tao, Zeyuan Guan, Tingting Zou

Journal: Nature Communications

PubMed ID: 40097437

Doi: 10.1038/s41467-025-57851-1

Structural basis of gap-filling DNA synthesis in the nucleosome by DNA Polymerase β

Authors: Tyler M Weaver, Benjamin J Ryan, Spencer H Thompson, Adil S Hussen, Jonah J Spencer, Zhen Xu, Nicholas J Schnicker, Bret D Freudenthal

Journal: Nature Communications

PubMed ID: 40097433

Doi: 10.1038/s41467-025-57915-2

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Structural dynamics of DNA unwinding by a replicative helicase

Authors: Taha Shahid, Ammar U Danazumi, Muhammad Tehseen, Lubna Alhudhali, Alice R Clark, Christos G Savva, Samir M Hamdan, Alfredo De Biasio

Journal: Nature

PubMed ID: 40108462

Doi: 10.1038/s41586-025-08766-w

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Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action

Authors: Yang Li, Xuteng Lu, Xufeng Cheng, Keyu Xia, Junyan Hu, Peiyu Wang, Peiyuan Pang, Bomin Gao, Demeng Sun, Zhuzhen Zhang, Dongdong Li, Zengqin Deng, Changlin Tian, Chang Xie, Jing Yao

Journal: Nature Communications

PubMed ID: 40108208

Doi: 10.1038/s41467-025-58033-9

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Structural recognition and stabilization of tyrosine hydroxylase by the J-domain protein DNAJC12

Authors: Mary Dayne S Tai, Lissette Ochoa, Marte I Flydal, Lorea Velasco-Carneros, Jimena Muntaner, César Santiago, Gloria Gamiz-Arco, Fernando Moro, Kunwar Jung-Kc, David Gil-Cantero, Miguel Marcilla, Juha P Kallio, Arturo Muga, José María Valpuesta, Jorge Cuéllar, Aurora Martinez

Journal: Nature Communications

PubMed ID: 40113792

Doi: 10.1038/s41467-025-57733-6

Resilient Membranized Coacervates Formed through Spontaneous Wrapping of Heat-Destabilized Lipid Bilayers around Coacervate Droplets

Authors: Sadaf Javed, Evan Spruijt

Journal: Advanced Science

PubMed ID: 40116289

Doi: 10.1002/advs.202412312

Mimicry of molecular glues using dual covalent chimeras

Authors: Eden Kapcan, Karolina Krygier, Maya da Luz, Nickolas J Serniuck, Ali Zhang, Jonathan Bramson, Anthony F Rullo

Journal: Nature Communications

PubMed ID: 40128528

Doi: 10.1038/s41467-025-58083-z

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Conformational reorganization and phase separation drive hyper-editing of ADR-2-ADBP-1 complex

Authors: Jianqiang Mu, Cang Wu, Kaiming Xu, Xingang Liu, Yajuan Fu, Zhen Zhang, Jingwei Yu, Chenyang Xue, Zi Wang, Xinmeng Chen, Yanhong Chen, Guangshuo Ou, Zhongmin Liu

Journal: Nucleic Acids Res

PubMed ID: 40037706

Doi: 10.1093/nar/gkaf148

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair

Authors: Alexander J Garvin, Alexander J Lanz, George E Ronson, Matthew J W Mackintosh, Katarzyna Starowicz, Alexandra K Walker, Yara Aghabi, Hannah MacKay, Ruth M Densham, Jai S Bhachoo, Aneika C Leney, Joanna R Morris

Journal: Mol Cell

PubMed ID: 40054443

Doi: 10.1016/j.molcel.2025.02.004

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The OsIAA3-OsARF16-OsBUL1 auxin signaling module regulates grain size in rice

Authors: Fengjun Xian, Shuya Liu, Jishuai Huang, Bin Xie, Lin Zhu, Qiannan Zhang, Chen Lv, Yimeng Xu, Xinrong Zhang, Jun Hu

Journal: Plant Physiol

PubMed ID: 40156155

Doi: 10.1093/plphys/kiaf122

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ER nests are specialized ER subdomains in Arabidopsis where peroxisomes and lipid droplets form

Authors: Zachary J Wright , Nathan E Tharp , Bonnie Bartel

Journal: Developmental Cell

Doi: 10.1016/j.devcel.2025.03.005

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Active- and Allosteric-Site Cyclic Peptide Inhibitors of Secreted M. tuberculosis Chorismate Mutase

Authors: Renier H P van Neer, Patricia K Dranchak, Mahesh Aitha, Lijun Liu, Emma K Carlson, Isabella E Jacobsen, Kevin Battaile, Yuhong Fang, Dingyin Tao, Ganesha Rai, Janak Padia, Scott Lovell, Hiroaki Suga, James Inglese

Journal: ACS Infectious Diseases

PubMed ID: 39903128

Doi: 10.1021/acsinfecdis.4c00798

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Potential role of TRAF2 in pulmonary hypertension in broiler chickens and preparation and specificity analysis of its polyclonal antibody

Authors: Wen Peng, Gen Wan, Sufang Cheng, Guyue Li, Liling Liu, Juan Chen, Pei Liu, Xiaoquan Guo, Xiaona Gao, Gaofeng Cai, Zhanhong Zheng, Ping Liu

Journal: Int J Biol Macromol

PubMed ID: 39798767

Doi: doi.org/10.1016/j.ijbiomac.2025.139741

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Structural basis for the allosteric activation of Lon by the heat shock protein LarA

Authors: Hsiu-Jung Wang, Yun-Erh Kuan, Meng-Ru Ho, Chung-I Chang

Journal: Nature Communications

PubMed ID: 40044692

Doi: 10.1038/s41467-025-57482-6

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Integration of multi-omics data accelerates molecular analysis of common wheat traits

Authors: Ning Zhang, Li Tang, Songgang Li, Lu Liu, Mengjuan Gao, Sisheng Wang, Daiying Chen, Yichao Zhao, Ruiqing Zheng, Armin Soleymaniniya, Lingran Zhang, Wenkang Wang, Xia Yang, Yan Ren, Congwei Sun, Mathias Wilhelm, Daowen Wang, Min Li, Feng Chen

Journal: Nature Communications

PubMed ID: 40038279

Doi: 10.1038/s41467-025-57550-x

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Immunomodulatory role of the stem cell circadian clock in muscle repair

Authors: Pei Zhu, Eric M Pfrender, Adam W T Steffeck, Colleen R Reczek, Yalu Zhou, Abhishek Vijay Thakkar, Neha R Gupta, Ariana Kupai, Amber Willbanks, Richard L Lieber, Ishan Roy, Navdeep S Chandel, Clara B Peek

Journal: SCIENCE ADVANCES

PubMed ID: 40043110

Doi: 10.1126/sciadv.adq8538

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Epstein-Barr virus infection promotes T cell dysregulation in a humanized mouse model of multiple sclerosis

Authors: Jessica R Allanach, Naomi M Fettig, Blair K Hardman, Ariel R Rosen, Vina Fan, Cynthia Chung, Erin J Goldberg, Zachary J Morse, Iryna Shanina, Galina Vorobeychik, Lisa C Osborne, Marc S Horwitz

Journal: SCIENCE ADVANCES

PubMed ID: 40043135

Doi: 10.1126/sciadv.adu5110

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Elevated NAD+ drives Sir2A-mediated GCβ deacetylation and OES localization for Plasmodium ookinete gliding and mosquito infection

Authors: Yang Shi, Lin Wan, Mengmeng Jiao, Chuan-Qi Zhong, Huiting Cui, Jing Yuan

Journal: Nature Communications

PubMed ID: 40050296

Doi: 10.1038/s41467-025-57517-y

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Enhancing Prime Editing Efficiency Through Modulation of Methylation on the Newly Synthesized DNA Strand and Prolonged Expression

Authors: Xiaosong Han, Xianghua Xu, Youcai Xiong, Guangxing Zhao, Ruigao He, Yinyu Su, Sheng Li, Changzhi Zhao, Xiaoning Xi, Yunxia Zhao, Xuewen Xu, Shengsong Xie, Heng Wang, Xinyun Li, Shuhong Zhao, Jinxue Ruan

Journal: Advanced Science

PubMed ID: 40051369

Doi: 10.1002/advs.202417790

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Soft-matter-induced orderings in a solid-state van der Waals heterostructure

Authors: Kai Zhao, Baojuan Dong, Yuang Wang, Xiaoxue Fan, Qi Wang, Zhiren Xiong, Jing Zhang, Jinkun He, Kaining Yang, Minru Qi, Chengbing Qin, Tongyao Zhang, Maolin Chen, Hanwen Wang, Jianqi Huang, Kai Liu, Hanwei Huang, Kenji Watanabe, Takashi Taniguchi, Yaning Wang, Xixiang Zhang, Juehan Yang, Zhenwen Huang, Yongjun Li, Zhongming Wei, Jing Zhang, Shuoxing Jiang, Zheng Vitto Han, Funan Liu

Journal: Nature Communications

PubMed ID: 40064923

Doi: 10.1038/s41467-025-57690-0

A globular protein exhibits rare phase behavior and forms chemically regulated orthogonal condensates in cells

Authors: Jinglei Nie, Xinyi Zhang, Zhijuan Hu, Wei Wang, Martin A Schroer, Jie Ren, Dmitri Svergun, Anyang Chen, Peiguo Yang, An-Ping Zeng

Journal: Nature Communications

PubMed ID: 40069234

Doi: 10.1038/s41467-025-57886-4

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Overlapping and separable activities of BRA-2 and HIM-17 promote occurrence and regulation of pairing and synapsis during Caenorhabditis elegans meiosis

Authors: Jitka Blazickova, Shalini Trivedi, Richard Bowman, Sowmya Sivakumar Geetha, Silma Subah, Michelle Scuzzarella, Alexander Chang, Uma R Chandran, Judith L Yanowitz, Sarit Smolikove, Verena Jantsch, Monique Zetka, Nicola Silva

Journal: Nature Communications

PubMed ID: 40082424

Doi: 10.1038/s41467-025-57862-y

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Cryo-EM Analysis of a Tri-Heme Cytochrome-Associated RC-LH1 Complex from the Marine Photoheterotrophic Bacterium Dinoroseobacter Shibae

Authors: Weiwei Wang, Yanting Liu, Jiayi Gu, Shaoya An, Cheng Ma, Haichun Gao, Nianzhi Jiao, Jian-Ren Shen, John Thomas Beatty, Michal Koblížek, Xing Zhang, Qiang Zheng, Jing-Hua Chen

Journal: Advanced Science

PubMed ID: 40112203

Doi: 10.1002/advs.202413456

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Selective promotion of sensory innervation-mediated immunoregulation for tissue repair

Authors: Kaicheng Xu, Kaile Wu, Liang Chen, Yubin Zhao, Hengyuan Li, Nong Lin, Zhaoming Ye, Jianbin Xu, Donghua Huang, Xin Huang

Journal: SCIENCE ADVANCES

PubMed ID: 40117376

Doi: 10.1126/sciadv.ads9581

Functional and antigenic landscape of the Nipah virus receptor-binding protein

Authors: Brendan B Larsen, Teagan McMahon, Jack T Brown, Zhaoqian Wang, Caelan E Radford, James E Crowe Jr, David Veesler, Jesse D Bloom

Journal: Cell

PubMed ID: 38659959

Doi: 10.1101/2024.04.17.589977

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Rational Design Assisted by Evolutionary Engineering Allows (De)Construction and Optimization of Complex Phenotypes in Pseudomonas putida KT2440

Authors: Blas Blázquez, Juan Nogales

Journal: Microbial biotechnology

PubMed ID: 40126873

Doi: 10.1111/1751-7915.70132

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Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus

Authors: Yansi Xian, Bin Liu, Tao Shen, Lin Yang, Rui Peng, Hongdou Shen, Xueying An, Yutian Wang, Yu Ben, Qing Jiang, Baosheng Guo

Journal: Bone Res

PubMed ID: 40025004

Doi: 10.1038/s41413-024-00399-5

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Structure-Guided Development of Chemically Tailored Peptide Binders of RNF43/ZNRF3 to Enable Versatile Design of Membrane Protein-Targeting PROTACs

Authors: Jibin Cui , Qingyun Zheng , Yicheng Weng , Xiaoguo Zhai , Zhen Su , Yunxiang Du , Xiaoxiong Wei , Yuanyuan Yu , Qian Qu , Man Pan

Journal: Analytical Chemistry

PubMed ID: 40000409

Doi: doi.org/10.1002/anie.202501488

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Structural mechanisms underlying the modulation of CXCR4 by diverse small-molecule antagonists

Authors: Xiaohong Sang, Haizhan Jiao, Qian Meng, Xiong Fang, Qi Pan, Jiao Zhou, Tingli Qian, Wanqin Zhang, Yan Xu, Jing An, Ziwei Huang, Hongli Hu

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 40063796

Doi: 10.1073/pnas.2425795122

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Design of CoQ10 crops based on evolutionary history

Authors: Jing-Jing Xu, Yuan Lei, Xiao-Fan Zhang, Jian-Xu Li, Qiupeng Lin, Xiang-Dong Wu, Yu-Guo Jiang, Wenyi Zhang, Runtong Qian, Shu-Yi Xiong, Kuo Tan, Yu Jia, Qiang Zhou, Yan Jiang, Hang Fan, Yan-Bo Huang, Ling-Jian Wang, Ji-Yun Liu, Yu Kong, Qing Zhao, Lei Yang, Jinxing Liu, Yong-Hong Hu, Shuai Zhan, Caixia Gao, Xiao-Ya Chen

Journal: Cell

PubMed ID: 39952246

Doi: 10.1016/j.cell.2025.01.023

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Evaluation of Cas13d as a tool for genetic interaction mapping

Authors: Ghanem El Kassem, Jasmine Hillmer, Michael Boettcher

Journal: Nature Communications

PubMed ID: 39952934

Doi: 10.1038/s41467-025-56747-4

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Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer

Authors: Xue Yang, Xiuquan Ma, Tianyue Zhao, David R Croucher, Elizabeth V Nguyen, Kimberley C Clark, Changyuan Hu, Sharissa L Latham, Charles Bayly-Jones, Bao V Nguyen, Srikanth Budnar, Sung-Young Shin, Lan K Nguyen, Thomas R Cotton, Anderly C Chüeh, Terry C C Lim Kam Sian, Margaret M Stratton, Andrew M Ellisdon, Roger J Daly

Journal: Nature Communications

PubMed ID: 39984440

Doi: 10.1038/s41467-025-57046-8

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The TaCLE24b peptide signaling cascade modulates lateral root development and drought tolerance in wheat

Authors: Wen Yang, Man Feng, Kuohai Yu, Jie Cao, Guangxian Cui, Yumei Zhang, Huiru Peng, Yingyin Yao, Zhaorong Hu, Zhongfu Ni, Feng Qin, Fuminori Takahashi, Qixin Sun, Mingming Xin

Journal: Nature Communications

PubMed ID: 40000659

Doi: 10.1038/s41467-025-57291-x

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RH3 enhances antiviral defense by facilitating small RNA loading into Argonaute 2 at endoplasmic reticulum–chloroplast membrane contact sites

Authors: Juan Huang, Juan Du, Yan Liu, Lu Lu, Yanzhuo Xu, Jianfei Shi, Qing Liu, Qi Li, Yang Liu, Yaqiu Chen, Meng Du, Yiming Zhao, Liangxiao Huo, Weiran Wang, Chenxi Ding, Liya Wei, Jianguo Wu, Yao-Wu Yuan, Jinfeng Chen, Ruixi Li, Feng Cui, Xiaoming Zhang

Journal: Nature Communications

PubMed ID: 40000658

Doi: 10.1038/s41467-025-57296-6

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CK2B Induces CD8+ T-Cell Exhaustion through HDAC8-Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti-PD-1 Therapy in Non-Small-Cell Lung Cancer

Authors: Shaochuan Liu, Shiya Ma, Gen Liu, Lingjie Hou, Yong Guan, Liang Liu, Yuan Meng, Wenwen Yu, Ting Liu, Li Zhou, Zhiyong Yuan, Shuju Pang, Siyuan Zhang, Junyi Li, Xiubao Ren, Qian Sun

Journal: Advanced Science

PubMed ID: 40013761

Doi: 10.1002/advs.202411053

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Activation of the bacterial defenseassociated sirtuin system

Authors: Kaixiang Zhu, Kun Shang, Linyue Wang, Xia Yu, Lei Hua, Weihe Zhang, Bo Qin, Jia Wang, Xiaopan Gao, Hongtao Zhu, Sheng Cui

Journal: Communications Biology

PubMed ID: 39994439

Doi: doi.org/10.1038/s42003-025-07743-3

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Structures of HCoV-OC43 HR1 Domain in Complex with Cognate HR2 or Analogue EK1 Peptide

Authors: Xiuxiu He, Huanzhen Liu, Guang Yang, Lei Yan

Journal: Viruses-Basel

PubMed ID: 40143271

Doi: 10.3390/v17030343

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Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma

Authors: Yiliang Jin, Baoli Zhang, Jianru Li, Zhenxi Guo, Chen Zhang, Xuehui Chen, Long Ma, Zhuoran Wang, Haiyin Yang, Yong Li, Yuhua Weng, Yuanyu Huang, Xiyun Yan, Kelong Fan

Journal: SCIENCE ADVANCES

PubMed ID: 39970222

Doi: 10.1126/sciadv.adr9266

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Oral delivery of therapeutic proteins by engineered bacterial type zero secretion system

Authors: Xu Gong , Shan Liu , Bozhang Xia , Yichen Wan , Shuyi Zhang , Baoyan Zhang , Zehao Wang , Junge Chen , Fei Xiao , Xing-Jie Liang , Yun Yang

Journal: Nat Commun

PubMed ID: 39984501

Doi: 10.1038/s41467-025-57153-6

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EXPERT expands prime editing efficiency and range of large fragment edits

Authors: Youcai Xiong , Yinyu Su , Ruigao He , Xiaosong Han , Sheng Li , Minghuan Liu , Xiaoning Xi , Zijia Liu , Heng Wang , Shengsong Xie , Xuewen Xu , Kui Li , Jifeng Zhang , Jie Xu , Xinyun Li , Shuhong Zhao , Jinxue Ruan

Journal: Nat Commun

PubMed ID: 39939583

Doi: 10.1038/s41467-025-56734-9

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Self-assembly GSH response based Buforin IIb-Olaparib nanocombination synergistically promotes DNA damage for prostate cancer immunotherapy

Authors: Maosong Hu , Yuyu Zhu , Xinyi Tang , Jing Xu , Hanbin Ma , Zhihan Chen , Duo Chen , Wenyuan Wu , Xialin Chen , Rongrong He , Jing Zhou , Jinao Duan , Weiguo Chen , Hongyue Ma

Journal: Chemical Engineering Journal

Doi: 10.1016/j.cej.2025.160862

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Deciphering molecular specificity in MCL-1/BAK interaction and its implications for designing potent MCL-1 inhibitors

Authors: Hudie Wei, Haolan Wang, Shuang Xiang, Jiaqi Wang, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Xiaoyun Lu, Yongheng Chen

Journal: Cell Death Differ

PubMed ID: 39901037

Doi: 10.1038/s41418-025-01454-2

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Expanding Cas12a Activity Control with an RNA G-Quadruplex at the 5′ end of CRISPR RNA

Authors: Wenjuan Huang, Jiaqi Wang, Cheng Wang, Yuanfang Liu, Wentao Li, Qiaozhen Chen, Junqiu Zhai, Zhenyang Xiang, Chaoxing Liu

Journal: Advanced Science

PubMed ID: 39721016

Doi: 10.1002/advs.202411305

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Structural and mechanistic insights into the activation of a short prokaryotic argonaute system from archaeon Sulfolobus islandicus

Authors: Zhikang Dai, Yu Chen, Zeyuan Guan, Xueting Chen, Keyi Tan, Kaiyue Yang, Xuhui Yan, Yidong Liu, Zhou Gong, Wenyuan Han, Tingting Zou

Journal: Nucleic Acids Res

PubMed ID: 39898546

Doi: 10.1093/nar/gkaf059

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Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors

Authors: Sergio M Quiñones-Parra, Stephanie Gras, Thi H O Nguyen, Carine Farenc, Christopher Szeto, Louise C Rowntree, Priyanka Chaurasia, Sneha Sant, Adrianus C M Boon, Dhilshan Jayasinghe, Guus F Rimmelzwaan, Jan Petersen, Peter C Doherty, Adam P Uldrich, Dene R Littler, Jamie Rossjohn, Katherine Kedzierska

Journal: Science immunology

PubMed ID: 39919196

Doi: 10.1126/sciimmunol.adn3805

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Structure of the tilapia lake virus nucleoprotein bound to RNA

Authors: Benoît Arragain, Martin Pelosse, Karine Huard, Stephen Cusack

Journal: Nucleic Acids Res

PubMed ID: 39995042

Doi: 10.1093/nar/gkaf112

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Bacteria encode post-mortem protein catabolism that enables altruistic nutrient recycling

Authors: Savannah E R Gibson, Isabella Frost, Stephen J Hierons, Tessa Moses, Wilson C K Poon, Stuart A West, Martin J Cann

Journal: Nature Communications

PubMed ID: 39948360

Doi: 10.1038/s41467-025-56761-6

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Genetic regulation of TERT splicing affects cancer risk by altering cellular longevity and replicative potential

Authors: Oscar Florez-Vargas, Michelle Ho, Maxwell H Hogshead, Brenen W Papenberg, Chia-Han Lee, Kaitlin Forsythe, Kristine Jones, Wen Luo, Kedest Teshome, Cornelis Blauwendraat, Kimberly J Billingsley, Mikhail Kolmogorov, Melissa Meredith, Benedict Paten, Raj Chari, Chi Zhang, John S Schneekloth, Mitchell J Machiela, Stephen J Chanock, Shahinaz M Gadalla, Sharon A Savage, Sam M Mbulaiteye, Ludmila Prokunina-Olsson

Journal: Nature Communications

PubMed ID: 39956830

Doi: 10.1038/s41467-025-56947-y

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CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair

Authors: Feng Li, Tianpeng Zhang, Aleem Syed, Amira Elbakry, Noella Holmer, Huy Nguyen, Sirisha Mukkavalli, Roger A Greenberg, Alan D D'Andrea

Journal: Nature Communications

PubMed ID: 39962076

Doi: 10.1038/s41467-025-56834-6

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RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer

Authors: Zachary Sethna, Pablo Guasp, Charlotte Reiche, Martina Milighetti, Nicholas Ceglia, Erin Patterson,on Jay Lihm, George Payne, Olga Lyudovyk, Luis A Rojas, Nan Pang, Akihiro Ohmoto, Masataka Amisaki, Abderezak Zebboudj, Zagaa Odgerel, Emmanuel M Bruno, Siqi Linsey Zhang, Charlotte Cheng, Yuval Elhanati, Evelyna Derhovanessian, Luisa Manning, Felicitas Müller, Ina Rhee, Mahesh Yad,av Taha Merghoub, Jedd D Wolchok, Olca Basturk, Mithat Gönen, Andrew S Epstein, Parisa Momtaz, Wungki Park, Ryan Sugarman, Anna M Varghese, Elizabeth Won, Avni Desai, Alice C Wei, Michael I D'Angelica, T Peter Kingham, Kevin C Soares, William R Jarnagin, Jeffrey Drebin, Eileen M O'Reilly, Ira Mellman, Ugur Sahin, Özlem Türeci, Benjamin D Greenbaum, Vinod P Balachandran

Journal: Nature

PubMed ID: 39972124

Doi: 10.1038/s41586-024-08508-4

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Cooperative nutrient scavenging is an evolutionary advantage in cancer

Authors: Gizem Guzelsoy, Setiembre D Elorza, Manon Ros, Logan T Schachtner, Makiko Hayashi, Spencer Hobson-Gutierrez, Parker Rundstrom, Julia S Brunner, Ray Pillai, William E Walkowicz, Lydia W S Finley, Maxime Deforet, Thales Papagiannakopoulos, Carlos Carmona-Fontaine

Journal: Nature

PubMed ID: 39972131

Doi: 10.1038/s41586-025-08588-w

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Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota

Authors: Jana Ordon、Elke Logemann、Louis-Philippe Maier、Tak Lee、Eik Dahms、Anniek Oosterwijk、Jose Flores-Uribe、Shingo Miyauchi、Lucas Paoli、Sara Christina Stolze、Hirofumi Nakagami、Georg Felix、Ruben Garrido-Oter、Ka-Wai Ma 和 Paul Schulze-Lefert

Journal: Nat Plants

PubMed ID: 39972185

Doi: 10.1038/s41477-025-01918-w

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Structural basis of ssDNA-guided NADase activation of prokaryotic SPARTA system

Authors: Rong Hu, Chenmin Guo, Xiaotian Liu, Yuanyi Lin, Zixin Yang, Zhixin Li, Ye Yang, Erman Ma, Yiyi Li, Jiyun Chen, Liang Liu

Journal: Nucleic Acids Res

PubMed ID: 39997222

Doi: 10.1093/nar/gkaf110

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Reversible ubiquitination conferred by domain shuffling controls paired NLR immune receptor complex homeostasis in plant immunity

Authors: Zhiyi Chen, Jianhua Huang, Jianyu Li, Frank L. H. Menke, Jonathan D. G. Jones & Hailong Guo