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The gene "degrees of kevin bacon" (dokb) regulates a social network behaviour in Drosophila melanogaster

Authors: Rebecca Rooke, Joshua J Krupp, Amara Rasool, Mireille Golemiec, Megan Stewart, Jonathan Schneider, Joel D Levine

Journal: Nat Commun

PubMed ID: 38688961

Doi: 10.1038/s41467-024-47499-8

Products & Services: Peptide Synthesis

Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology

Authors: Keming Lin, Baijin Xia, Xuemei Wang, Xin He, Mo Zhou, Yingtong Lin, Yidan Qiao, Rong Li, Qier Chen, Yuzhuang Li, Jinzhu Feng, Tao Chen, Cancan Chen, Xinyu Li, Hui Zhang, Lijuan Lu, Bingfeng Liu, Xu Zhang

Journal: J Transl Med

PubMed ID: 38610029

Doi: 10.1186/s12967-024-05159-x

Products & Services: Proteins, Expression, Isolation and Analysis

Visualization of the Association of Dimeric Protein Complexes on Specific Enhancers in the Salivary Gland Nuclei of Larva

Authors: Solène Vanderperre, Samir Merabet

Journal: Cells

PubMed ID: 38607052

Doi: 10.3390/cells13070613

Products & Services: Gene Synthesis

Systemic Effects of a Phage Cocktail on Healthy Weaned Piglets

Authors: Yankun Liu, Yan Lin, Weiyun Zhu

Journal: Biology (Basel)

PubMed ID: 38666883

Doi: 10.3390/biology13040271

Products & Services: Catalog Peptides

Expanding the Potential of Neoantigen Vaccines: Harnessing Bacille Calmette-Guérin Cell-Wall-Based Nanoscale Adjuvants for Enhanced Cancer Immunotherapy

Authors: Kangkang Liu, Jing Peng, Yunfei Guo, Yiming Li, Xiang Qi, Dengyi Duan, Taipeng Li, Jianmin Li, Yuanjie Niu, Gang Han, Yang Zhao

Journal: ACS Nano

PubMed ID: 38680054

Doi: 10.1021/acsnano.4c01691

Products & Services: Proteins, Expression, Isolation and Analysis

The use of Bacillus subtilis as a cost-effective expression system for production of Cholera Toxin B fused factor VIII epitope regions applicable for inducing oral immune tolerance

Authors: Vijay Elakkya Vijayakumar, Mookambeswaran A Vijayalakshmi, Sebastien Lacroix-Desmazes, Krishnan Venkataraman

Journal: Folia Microbiol (Praha)

PubMed ID: 38683262

Doi: 10.1007/s12223-024-01166-z

Products & Services: Molecular Biology Reagents

Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy

Authors: Bo-Xin Zheng, Wei Long, Wende Zheng, Yaoxun Zeng, Xiao-Chun Guo, Ka-Hin Chan, Meng-Ting She, Alan Siu-Lun Leung, Yu-Jing Lu, Wing-Leung Wong

Journal: J Med Chem

PubMed ID: 38624086

Doi: 10.1021/acs.jmedchem.3c02240

Products & Services: Gene Synthesis

The molecular immune modulator adenosine deaminase-1 enhances HIV specific humoral and cellular responses to a native-like HIV envelope trimer DNA vaccine

Authors: Michele A Kutzler, Gina Cusimano, David Joyner, Emily Konopka, Roshell Muir, Philip Barnette, Melanie Guderian, Iván Del Moral-Sánchez, Ronald Derking, Tom Bijl, Jonne Snitselaar, Photis Rotsides, Kyra Woloszczuk, Matthew Bell, Gabriela Canziani, Irwin Chaiken, Ann Hessell, Yannic Bartsch, Rogier Sanders, Elias Haddad

Journal: Res Sq

PubMed ID: 38746176

Doi: 10.21203/rs.3.rs-4139764/v1

Products & Services: Gene Synthesis

A new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers

Authors: Dan-Dan Zhou, Xiao-Tian Zhai, Lan-Wen Zhang, Zi-Hui Xie, Ying Wang, Yong-Su Zhen, Rui-Juan Gao, Qing-Fang Miao

Journal: NPJ Precis Oncol

PubMed ID: 38654141

Doi: 10.1038/s41698-024-00584-z

Products & Services: Proteins, Expression, Isolation and Analysis

Combination of a TGF-β ligand trap (RAP-GRL) and TMPRSS6-ASO is superior for correcting β-thalassemia

Authors: Amaliris Guerra, Nolan Hamilton, Ariel Rivera, Perry Demsko, Shuling Guo, Stefano Rivella

Journal: Am J Hematol

PubMed ID: 38659383

Doi: 10.1002/ajh.27332

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening

Authors: Xing Li, Shiyu Sun, Wansong Zhang, Ziwei Liang, Yitong Fang, Tianhu Sun, Yong Wan, Xingcong Ma, Shuqun Zhang, Yang Xu, Ruilin Tian

Journal: Experimental & Clinical Cancer Research

PubMed ID: 38561797

Doi: 10.1186/s13046-024-03027-6

Products & Services: Recombinant Proteins

Cellugyrin (synaptogyrin-2) dependent pathways are used by bacterial cytolethal distending toxin and SARS-CoV-2 virus to gain cell entry

Authors: Kathleen Boesze-Battaglia, Gary H Cohen, Paul F Bates, Lisa M Walker, Ali Zekavat, Bruce J Shenker

Journal: Front Cell Infect Microbiol

PubMed ID: 38698905

Doi: 10.3389/fcimb.2024.1334224

Products & Services: Proteins, Expression, Isolation and Analysis

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

Authors: Guy J Pearson, Harriet V Mears, Malgorzata Broncel, Ambrosius P Snijders, David L V Bauer, Jeremy G Carlton

Journal: SCIENCE ADVANCES

PubMed ID: 38569033

Doi: 10.1126/sciadv.adl5012

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Interplay of the Tfb1 pleckstrin homology domain with Rad2 and Rad4 in transcription coupled and global genomic nucleotide excision repair

Authors: Wenzhi Gong, Hannah Holmberg, Cheng Lu, Michelle Huang, Shisheng Li

Journal: Nucleic Acids Res

PubMed ID: 38634797

Doi: 10.1093/nar/gkae286

Products & Services: Catalog Antibody

Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway

Authors: Yan Yan, Jun Xiao, Fengtao Huang, Wei Xian, Bingbing Yu, Rui Cheng, Hui Wu, Xueling Lu, Xionglue Wang, Wenjing Huang, Jing Li, Greater Kayode Oyejobi, Carol V Robinson, Hao Wu, Di Wu, Xiaoyun Liu, Longfei Wang, Bin Zhu

Journal: Nat Microbiol

PubMed ID: 38649411

Doi: 10.1038/s41564-024-01684-z

Products & Services: Codon Optimization

Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editing

Authors: Qiubing Chen, Xuebin Wang, Yizhou Zhang, Ming Tian, Junyi Duan, Ying Zhang, Hao Yin

Journal: NSR

Doi: 10.1093/nsr/nwae135

Products & Services: Gene Synthesis

pH-dependent regulation of an acidophilic -acetylhomoserine sulfhydrylase from

Authors: Yasuyuki Matoba, Kosuke Oda, Maho Wataeda, Hina Kanemori, Koichi Matsuo

Journal: Appl Environ Microbiol

PubMed ID: 38568076

Doi: 10.1128/aem.00118-24

Products & Services: Mutagenesis Services

A conserved motif in the immune-subdominant RAP-1 related antigen of contains a B-cell epitope recognized by antibodies from protected cattle

Authors: Manuel J Rojas, Reginaldo G Bastos, Jinna Navas, Jacob M Laughery, Paul A Lacy, Carlos E Suarez

Journal: Front Immunol

PubMed ID: 38720894

Doi: 10.3389/fimmu.2024.1380660

Products & Services: Proteins, Expression, Isolation and Analysis

Food for Thought: The Effects of Feeding on Neurogenesis in the Ball Python, Python regius

Authors: Hannah Bow, Christina Dang, Katherine Hillsbery, Carly Markowski, Michael Black, Christine Strand

Journal: Brain Behav Evol

PubMed ID: 38657588

Doi: 10.1159/000539052

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Synthesis of site-specific Fab-drug conjugates using ADP-ribosyl cyclases

Authors: Hyo Sun Kim, Kimia Hariri, Xiao-Nan Zhang, Liang-Chieh Chen, Benjamin B Katz, Hua Pei, Stan G Louie, Yong Zhang

Journal: Protein Sci

PubMed ID: 38501590

Doi: 10.1002/pro.4924

Products & Services: Proteins, Expression, Isolation and Analysis

Development of an effective single-chain variable fragment recognizing a novel epitope in the hepatitis C virus E2 protein that restricts virus entry into hepatocytes

Authors: Soma Das, Padmanava Behera, Dipeshwari J Shewale, Janhavi Bodele, Saumitra Das, Anjali A Karande

Journal: Arch Virol

PubMed ID: 38683226

Doi: 10.1007/s00705-024-06024-4

Products & Services: Gene Synthesis

MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus

Authors: Tao Wang, Dan Song, Xuejuan Li, Yu Luo, Dianqiang Yang, Xiaoyan Liu, Xiaodan Kong, Yida Xing, Shulin Bi, Yan Zhang, Tao Hu, Yunyun Zhang, Shuang Dai, Zhiqiang Shao, Dahan Chen, Jinpao Hou, Esteban Ballestar, Jianchun Cai, Feng Zheng, James Y Yang

Journal: Cell Commun Signal

PubMed ID: 38589923

Doi: 10.1186/s12964-024-01601-1

Products & Services: Peptide Modifications

Searching for new plastic-degrading enzymes from the plastisphere of alpine soils using a metagenomic mining approach

Authors: Beat Frey, Margherita Aiesi, Basil M Rast, Joel Rüthi, Jérôme Julmi, Beat Stierli, Weihong Qi, Ivano Brunner

Journal: PLoS ONE

PubMed ID: 38578779

Doi: 10.1371/journal.pone.0300503

Products & Services: Molecular Biology Reagents

A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells

Authors: Hema Preethi Subas Satish, Sweta Iyer, Melissa X Shi, Agnes W Wong, Karla C Fischer, Ahmad Z Wardak, Daisy Lio, Jason M Brouwer, Rachel T Uren, Peter E Czabotar, Michelle S Miller, Ruth M Kluck

Journal: Cell Death Differ

PubMed ID: 38582955

Doi: 10.1038/s41418-024-01289-3

Products & Services: Proteins, Expression, Isolation and Analysis

microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation

Authors: Xinghan Chen, Yueru Shen, Zheng Song, Xinliang Wang, Huaitong Yao, Yuan Cai, Zi-Ang Zhao, Bing Hu

Journal: J Genet Genomics

PubMed ID: 38582297

Doi: 10.1016/j.jgg.2024.03.016

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The proteomic analysis uncovers the cellular responses to the African swine fever virus membrane proteins p54, p17, and pB117L

Authors: Yuhong Chen, Jianqiang Ni, Chuanbin Wang, Xinyan Zhai, Tingrong Luo, Yi-Ping Li, Youchuan Wei, Yuliang Liu

Journal: Microbes Infect

PubMed ID: 38697277

Doi: 10.1016/j.micinf.2024.105348

Products & Services: Molecular Biology Reagents

Interleukin-2 is required for NKp30-dependent NK cell cytotoxicity by preferentially regulating NKp30 expression

Authors: Nayoung Kim, Eunbi Yi, Eunbi Lee, Hyo Jin Park, Hun Sik Kim

Journal: Front Immunol

PubMed ID: 38698855

Doi: 10.3389/fimmu.2024.1388018

Products & Services: Molecular Biology Reagents

Amino Terminal Acetylation of HOXB13 Regulates the DNA Damage Response in Prostate Cancer

Authors: Duy T Nguyen, Urvashi Mahajan, Duminduni Hewa Angappulige, Aashna Doshi, Nupam P Mahajan, Kiran Mahajan

Journal: Cancers (Basel)

PubMed ID: 38730575

Doi: 10.3390/cancers16091622

Products & Services: Molecular Biology Reagents

Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity

Authors: Qiongqiong Zhou, Deshi Shi, Yan-Dong Tang, Longfeng Zhang, Boli Hu, Chunfu Zheng, Li Huang, Changjiang Weng

Journal: PLoS Pathog

PubMed ID: 38669242

Doi: 10.1371/journal.ppat.1012146

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of a linear B-cell epitope on the "puff" loop of the Senecavirus A VP2 protein involved in receptor binding

Authors: Hanrong Zhou, Mingxia Sun, Shibo Su, Liang Meng, Wei Yang, Lan Yang, Xinqi Shi, Xin Li, Haiwei Wang, Hongwei Ma, Xuehui Cai, Yan-Dong Tang, Tongqing An, Fandan Meng

Journal: Front Microbiol

PubMed ID: 38716170

Doi: 10.3389/fmicb.2024.1387309

Products & Services: Proteins, Expression, Isolation and Analysis

Non-Invasive Delivery of Negatively Charged Nanobodies by Anodal Iontophoresis: When Electroosmosis Dominates Electromigration

Authors: Phedra Firdaws Sahraoui, Oscar Vadas, Yogeshvar N Kalia

Journal: Pharmaceutics

PubMed ID: 38675200

Doi: 10.3390/pharmaceutics16040539

Products & Services: Molecular Biology Reagents

Fluctuation of flavor quality in roasted duck: The consequences of raw duck preform's repetitive freeze-thawing

Authors: Ziwu Gao, Dequan Zhang, Ruiyun Wu, Jinhua He, Jiale Ma, Xiangxiang Sun, Minghui Gu, Zhenyu Wang

Journal: Food Res Int

PubMed ID: 38763675

Doi: 10.1016/j.foodres.2024.114424

Products & Services: Proteins, Expression, Isolation and Analysis

Dynamically stiffening biomaterials reveal age- and sex-specific differences in pulmonary arterial adventitial fibroblast activation

Authors: Mikala C Mueller, Yanmei Du, Lori A Walker, Chelsea M Magin

Journal: Matrix Biol Plus

PubMed ID: 38699486

Doi: 10.1016/j.mbplus.2024.100145

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Developing a Novel Enzalutamide-Resistant Prostate Cancer Model via AR F877L Mutation in LNCaP Cells

Authors: Ruifeng Wang, Shuhua Ma, Nengwei Xu, Yumiao Gan, Pengya Li, Jingying Zhang, Zhixiang Zhang, Qingyang Gu, Jian Xiang

Journal: Curr Protoc

PubMed ID: 38652202

Doi: 10.1002/cpz1.1033

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Hymenopteran-specific TRPA channel from the Texas leaf cutter ant (Atta texana) is heat and cold activated and expression correlates with environmental temperature

Authors: Julia M York, Timothy N Taylor, Sarah LaPotin, Ying Lu, Ulrich Mueller

Journal: Insect Sci

PubMed ID: 38605428

Doi: 10.1111/1744-7917.13364

Products & Services: Molecular Biology Reagents

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood

Authors: Mathias Jensen, Linn Stenfelt, Jennifer Ricci Hagman, Michael Jakob Pichler, Julia Weikum, Tine Sofie Nielsen, Annika Hult, Jens Preben Morth, Martin L Olsson, Maher Abou Hachem

Journal: Nat Microbiol

PubMed ID: 38684911

Doi: 10.1038/s41564-024-01663-4

Products & Services: Mutant Libraries

A DNA circuit that records molecular events

Authors: Mingzhi Zhang, Colin Yancey, Chao Zhang, Junyan Wang, Qian Ma, Linlin Yang, Rebecca Schulman, Da Han, Weihong Tan

Journal: SCIENCE ADVANCES

PubMed ID: 38578999

Doi: 10.1126/sciadv.adn3329

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Buffer choice and pH strongly influence phase separation of SARS-CoV-2 nucleocapsid with RNA

Authors: Nina C Kathe, Mihajlo Novakovic, Frédéric H-T Allain

Journal: Mol Biol Cell

PubMed ID: 38568799

Doi: 10.1091/mbc.E23-12-0500

Products & Services: Molecular Biology Reagents

Lysin and Lytic Phages Reduce Vibrio Counts in Live Feed and Fish Larvae

Authors: Jaime Romero, Sergueia Blas-Chumacero, Victoria Urzúa, Alejandro Villasante, Rafael Opazo, Felipe Gajardo, Claudio D Miranda, Rodrigo Rojas

Journal: Microorganisms

PubMed ID: 38792735

Doi: 10.3390/microorganisms12050904

Products & Services: Molecular Biology Reagents

LncRNA BlncAD1 Modulates Bovine Adipogenesis by Binding to MYH10, PI3K/Akt Signaling Pathway, and miR-27a-5p/CDK6 Axis

Authors: Xin Li, Zhongyi Hou, Shengbo Meng, Qihui Jia, Shanshan Xing, Zhitong Wang, Mengjuan Chen, Huifen Xu, Ming Li, Hanfang Cai

Journal: J Agric Food Chem

PubMed ID: 38661523

Doi: 10.1021/acs.jafc.4c00165

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OsATL32 ubiquitinates the reactive oxygen species-producing OsRac5-OsRbohB module to suppress rice immunity

Authors: Yuqing Yan, Hui Wang, Yan Bi, Jiajing Wang, Muhammad Noman, Dayong Li, Fengming Song

Journal: J Integr Plant Biol

PubMed ID: 38629772

Doi: 10.1111/jipb.13666

Products & Services: Proteins, Expression, Isolation and Analysis

Label-free detection of Aβ-42: a liquid crystal droplet approach for Alzheimer's disease diagnosis

Authors: Saumya Ranjan Pradhan, Ramadevi Suguru Pathinti, Ramesh Kandimalla, Krishnakanth Chithari, Madhava Rao Veeramalla N, Jayalakshmi Vallamkondu

Journal: RSC Adv

PubMed ID: 38628477

Doi: 10.1039/d4ra00615a

Products & Services: Proteins, Expression, Isolation and Analysis

Therapeutic application of circular RNA aptamers in a mouse model of psoriasis

Authors: Si-Kun Guo, Chu-Xiao Liu, Yi-Feng Xu, Xiao Wang, Fang Nan, Youkui Huang, Siqi Li, Shan Nan, Ling Li, Edo Kon, Chen Li, Meng-Yuan Wei, Rina Su, Jia Wei, Shiguang Peng, Nitay Ad-El, Jiaquan Liu, Dan Peer, Ting Chen, Li Yang, Ling-Ling Chen

Journal: Nat Biotechnol

PubMed ID: 38653797

Doi: 10.1038/s41587-024-02204-4

Products & Services: Proteins, Expression, Isolation and Analysis

Milligram-scale assembly and NMR fingerprint of tau fibrils adopting the Alzheimer's disease fold

Authors: Pu Duan, Nadia El Mammeri, Mei Hong

Journal: J Biol Chem

PubMed ID: 38679331

Doi: 10.1016/j.jbc.2024.107326

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Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria

Authors: Zhenqi Zhou, Alice Ma, Timothy M Moore, Dane M Wolf, Nicole Yang, Peter Tran, Mayuko Segawa, Alexander R Strumwasser, Wenjuan Ren, Kai Fu, Jonathan Wanagat, Alexander M van der Bliek, Rachelle Crosbie-Watson, Marc Liesa, Linsey Stiles, Rebecca Acin-Perez, Sushil Mahata, Orian Shirihai, Mark O Goodarzi, Michal Handzlik, Christian M Metallo, David W Walker, Andrea L Hevener

Journal: Sci Adv

PubMed ID: 38569044

Doi: 10.1126/sciadv.adl0389

Products & Services: Proteins, Expression, Isolation and Analysis

Recombinant expression and tryptophan-assisted analysis of human sweet taste receptor T1R3's extracellular domain in sweetener interaction studies

Authors: Soo-Bin Jin, Hyun-A Kim, Ji-Ae Shin, Na-Hee Jung, Seo-Young Park, Sungguan Hong, Kwang-Hoon Kong

Journal: Prep Biochem Biotechnol

PubMed ID: 38578840

Doi: 10.1080/10826068.2024.2336985

Products & Services: Molecular Biology Reagents

Tailored UPRE2 variants for dynamic gene regulation in yeast

Authors: Chufan Xiao, Xiufang Liu, Yuyang Pan, Yanling Li, Ling Qin, Zhibo Yan, Yunzi Feng, Mouming Zhao, Mingtao Huang

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38687789

Doi: 10.1073/pnas.2315729121

Products & Services: Molecular Biology Reagents

Analysis of the Immunogenicity of African Swine Fever F317L Protein and Screening of T Cell Epitopes

Authors: Ying Huang, Wenzhu Zhai, Zhen Wang, Yuheng He, Chunhao Tao, Yuanyuan Chu, Zhongbao Pang, Hongfei Zhu, Hong Jia

Journal: Animals (Basel)

PubMed ID: 38731330

Doi: 10.3390/ani14091331

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The hsa_circ_0082152 maintains NF-κB mRNA stability by binding to MTDH to promote anti-tuberculosis drug-induced liver injury

Authors: Lin Wang, Chunyan Meng, Yifei Long, Yue Liu, Luming Yang, Xuelei Gao, Shufeng Sun, Fumin Feng

Journal: Int J Biol Macromol

PubMed ID: 38670193

Doi: 10.1016/j.ijbiomac.2024.131793

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Flow Cytometry-Based Measurement of Antibodies Specific for Cell Surface-Expressed Folded SARS-CoV-2 Receptor-Binding Domains

Authors: Al Nasar Ahmed Sehgal, Jera Safran, Bernhard Kratzer, Pia Gattinger, Robert B Stieger, Laszlo Musiejovsky, Doris Trapin, Paul Ettel, Ulrike Körmöczi, Arno Rottal, Kristina Borochova, Yulia Dorofeeva, Inna Tulaeva, Milena Weber, Katharina Grabmeier-Pfistershammer, Thomas Perkmann, Ursula Wiedermann, Rudolf Valenta, Winfried F Pickl

Journal: Vaccines (Basel)

PubMed ID: 38675759

Doi: 10.3390/vaccines12040377

Products & Services: Proteins, Expression, Isolation and Analysis

Development of a novel monoclonal antibody-based competitive ELISA for antibody detection against bovine leukemia virus

Authors: Jing Wang, Chao Sun, Zhe Hu, Fang Wang, Jitao Chang, Ming Gao, Dandan Ye, Qi Jia, Hui Zou, Luc Willems, Zhigang Jiang, Xin Yin

Journal: Int J Biol Macromol

PubMed ID: 38621561

Doi: 10.1016/j.ijbiomac.2024.131446

Products & Services: Proteins, Expression, Isolation and Analysis

The Ser/Thr protein kinase FonKin4-poly(ADP-ribose) polymerase FonPARP1 phosphorylation cascade is required for the pathogenicity of watermelon fusarium wilt fungus f sp

Authors: Jiajing Wang, Yizhou Gao, Xiaohui Xiong, Yuqing Yan, Jiajun Lou, Muhammad Noman, Dayong Li, Fengming Song

Journal: Front Microbiol

PubMed ID: 38690366

Doi: 10.3389/fmicb.2024.1397688

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Immune response profiles from humans experimentally exposed to bites

Authors: Fernanda Fortes de Araujo, Maha Abdeladhim, Clarissa Teixeira, Kelly Hummer, Matthew D Wilkerson, Roseanne Ressner, Ines Lakhal-Naouar, Michael W Ellis, Claudio Meneses, Saule Nurmukhambetova, Regis Gomes, W David Tolbert, George W Turiansky, Marzena Pazgier, Fabiano Oliveira, Jesus G Valenzuela, Shaden Kamhawi, Naomi Aronson

Journal: Front Immunol

PubMed ID: 38633260

Doi: 10.3389/fimmu.2024.1335307

Products & Services: Proteins, Expression, Isolation and Analysis

High expression of PPP1CC promotes NHEJ-mediated DNA repair leading to radioresistance and poor prognosis in nasopharyngeal carcinoma

Authors: Ping Feng, Ying Wang, Na Liu, Yanming Chen, Yujun Hu, Zilu Huang, Ya Liu, Shuohan Zheng, Tongchao Jiang, Xiang Xiao, Wei Dai, Peng Huang, Yunfei Xia

Journal: Cell Death Differ

PubMed ID: 38589496

Doi: 10.1038/s41418-024-01287-5

Products & Services: Proteins, Expression, Isolation and Analysis

Lysine acetylation of Hsp163: Effect on its structure, chaperone function and influence towards the growth of Mycobacterium tuberculosis

Authors: Subhashree Barik, Alok Kumar Panda, Viplov Kumar Biswas, Sheetal Das, Ayon Chakraborty, Shibangini Beura, Rahul Modak, Sunil Kumar Raghav, Rajiv K Kar, Ashis Biswas

Journal: Int J Biol Macromol

PubMed ID: 38657928

Doi: 10.1016/j.ijbiomac.2024.131763

Products & Services: Proteins, Expression, Isolation and Analysis

Mammalian PIWI–piRNA–target complexes reveal features for broad and efficient target silencing

Authors: Zhiqing Li, Zhenzhen Li, Yuqi Zhang, Lunni Zhou, Qikui Xu, Lili Li, Lin Zeng, Junchao Xue, Huilin Niu, Jing Zhong, Qilu Yu, Dengfeng Li, Miao Gui, Yongping Huang, Shikui Tu, Zhao Zhang, Chun-Qing Song, Jianping Wu，En-Zhi Shen

Journal: Nat Struct Mol Biol

PubMed ID: 38658622

Doi: 10.1038/s41594-024-01287-6.

Products & Services: Proteins, Expression, Isolation and Analysis

Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04

Authors: Lijing Zhang, Xuping Xie, Hannan Luo, Runtong Qian, Yang Yang, Hongtao Yu, Jing Huang, Pei-Yong Shi, Qi Hu

Journal: Cell Discov

PubMed ID: 38594245

Doi: 10.1038/s41421-024-00673-0

Products & Services: Proteins, Expression, Isolation and Analysis

A long-acting FGF21 attenuates metabolic dysfunction-associated steatohepatitis-related fibrosis by modulating NR4A1-mediated Ly6C phenotypic switch in macrophages

Authors: Yue Ji, Yiliang Duan, Yuanyuan Li, Qingzhou Lu, Dingkang Liu, Yifan Yang, Ruilong Chang, Jing Tian, Wenbing Yao, Jun Yin, Xiangdong Gao

Journal: Br J Pharmacol

PubMed ID: 38679486

Doi: 10.1111/bph.16378

Products & Services: Molecular Biology Reagents

Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

Authors: Sofie J Desmet, Jonathan Thommis, Tineke Vanderhaeghen, Edmee M F Vandenboorn, Dorien Clarisse, Yunkun Li, Steven Timmermans, Daria Fijalkowska, Dariusz Ratman, Evelien Van Hamme, Lode De Cauwer, Bart Staels, Luc Brunsveld, Frank Peelman, Claude Libert, Jan Tavernier, Karolien De Bosscher

Journal: Mol Metab

PubMed ID: 38631478

Doi: 10.1016/j.molmet.2024.101938

Products & Services: Molecular Biology Reagents

Duration of antibody response to the receptor binding domain of SARS-CoV-2 in infected or vaccinated individuals - A one year retrospective cohort study

Authors: Martin Pasev, Angelina Trifonova, Andrey Velichkov, Velislava Terzieva

Journal: Int Immunopharmacol

PubMed ID: 38621337

Doi: 10.1016/j.intimp.2024.112084

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The nematode-trapping fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors

Authors: Chih-Yen Kuo, Rebecca J Tay, Hung-Che Lin, Sheng-Chian Juan, Guillermo Vidal-Diez de Ulzurrun, Yu-Chu Chang, Jason Hoki, Frank C Schroeder, Yen-Ping Hsueh

Journal: Nat Microbiol

PubMed ID: 38649409

Doi: 10.1038/s41564-024-01679-w

Products & Services: Proteins, Expression, Isolation and Analysis

Echinococcus granulosus ubiquitin-conjugating enzymes (E2D2 and E2N) promote the formation of liver fibrosis in TGFβ1-induced LX-2 cells

Authors: Xiaodi Du, Ruiqi Hua, Xue He, Wei Hou, Shengqiong Li, Aiguo Yang, Guangyou Yang

Journal: Parasit Vectors

PubMed ID: 38643149

Doi: 10.1186/s13071-024-06222-8

Products & Services: Proteins, Expression, Isolation and Analysis

Problems with paralogs: the promise and challenges of gene duplicates in evo-devo research

Authors: Kevin D Deem, Jennifer A Brisson

Journal: Integr Comp Biol

PubMed ID: 38565319

Doi: 10.1093/icb/icae009

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AKAP3-mediated type I PKA signaling is required for mouse sperm hyperactivation and fertility†

Authors: Zhongkun Liang, Chaowei Dai, Fenfen He, Yu Wang, Yihua Huang, Heying Li, Yongming Wu, Yafang Hu, Kaibiao Xu

Journal: Biol Reprod

PubMed ID: 38145487

Doi: 10.1093/biolre/ioad180

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FOXO1 is a master regulator of memory programming in CAR T cells

Authors: Alexander E Doan, Katherine P Mueller, Andy Y Chen, Geoffrey T Rouin, Yingshi Chen, Bence Daniel, John Lattin, Martina Markovska, Brett Mozarsky, Jose Arias-Umana, Robert Hapke, In-Young Jung, Alice Wang, Peng Xu, Dorota Klysz, Gabrielle Zuern, Malek Bashti, Patrick J Quinn, Zhuang Miao, Katalin Sandor, Wenxi Zhang, Gregory M Chen, Faith Ryu, Meghan Logun, Junior Hall, Kai Tan, Stephan A Grupp, Susan E McClory, Caleb A Lareau, Joseph A Fraietta, Elena Sotillo, Ansuman T Satpathy, Crystal L Mackall, Evan W Weber

Journal: Nature

PubMed ID: 38600391

Doi: 10.1038/s41586-024-07300-8

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Circ_0087851 suppresses colorectal cancer malignant progression through triggering miR-593-3p/BAP1-mediated ferroptosis

Authors: Ming Huang, Ting Gao, Xianyong Chen, Junlei Yi, Xuan Zhou

Journal: J Cancer Res Clin Oncol

PubMed ID: 38642144

Doi: 10.1007/s00432-024-05643-3

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Role of G326 in Determining the Aggregation Propensity of R3 Tau Repeat: Insights from Studies on R1R3 Tau Construct

Authors: Allwin Ebenezer Sahayaraj, Arshad Abdul Vahid, Asmita Dhara, Ann Teres Babu, Vinesh Vijayan

Journal: J Phys Chem B

PubMed ID: 38676652

Doi: 10.1021/acs.jpcb.4c00123

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mA-dependent upregulation of DDX21 by super-enhancer-driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia

Authors: Yanchun Zhao, Yutong Zhou, Yu Qian, Wenwen Wei, Xiangjie Lin, Shihui Mao, Jie Sun, Jie Jin

Journal: Clin Transl Med

PubMed ID: 38572589

Doi: 10.1002/ctm2.1628

Products & Services: Proteins, Expression, Isolation and Analysis

Corinthian Currants Promote the Expression of Paraoxonase-1 and Enhance the Antioxidant Status in Serum and Brain of 5xFAD Mouse Model of Alzheimer's Disease

Authors: Dimitris Lymperopoulos, Anastasia-Georgia Dedemadi, Maria-Lydia Voulgari, Eirini Georgiou, Ioannis Dafnis, Christina Mountaki, Eirini A Panagopoulou, Michalis Karvelas, Antonia Chiou, Vaios T Karathanos, Angeliki Chroni

Journal: Biomolecules

PubMed ID: 38672443

Doi: 10.3390/biom14040426

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Identification of hyperthermophilic D-allulose 3-epimerase from Thermotoga sp and its application as a high-performance biocatalyst for D-allulose synthesis

Authors: Ji-Dong Shen, Bao-Ping Xu, Te-Li Yu, Yong-Xiang Fei, Xue Cai, Liang-Gang Huang, Li-Qun Jin, Zhi-Qiang Liu, Yu-Guo Zheng

Journal: Bioprocess Biosyst Eng

PubMed ID: 38676737

Doi: 10.1007/s00449-024-02989-3

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Determination of optimum levels of binding antibody units (BAU) of new quantitative chemiluminescent immuno-assay (CLIA) in COVID-19 vaccinated volunteer blood donors

Authors: Aseem Kumar Tiwari, Geet Aggarwal, Pratibha Kale, Neeti Yadav, Virendra Kumar, Gargi Singh, K Cheirmaraj, K Krishnan

Journal: Transfus Apher Sci

PubMed ID: 38678985

Doi: 10.1016/j.transci.2024.103937

Products & Services: Proteins, Expression, Isolation and Analysis

Regulation by the RNA-binding protein Unkempt at its effector interface

Authors: Kriti Shah, Shiyang He, David J Turner, Joshua Corbo, Khadija Rebbani, Daniel Dominguez, Joseph M Bateman, Sihem Cheloufi, Cátia Igreja, Eugene Valkov, Jernej Murn

Journal: Nat Commun

PubMed ID: 38605040

Doi: 10.1038/s41467-024-47449-4

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Structural basis of exoribonucleasemediated mRNA transcription termination

Authors: Yuan Zeng, Hong-Wei Zhang, Xiao-Xian Wu, Yu Zhang

Journal: Nature

PubMed ID: 38538796

Doi: doi.org/10.1038/s41586-024-07240-3

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HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation

Authors: Carlotta Welters, Marthe-Lina Welters, Serena Stadler, Lars Bullinger, Julian Strobel, Holger Hackstein, Arunraj Dhamodaran, Thomas Blankenstein, Leo Hansmann

Journal: Haematologica

PubMed ID: 37767552

Doi: 10.3324/haematol.2023.283812

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Identification of PEX5-PTS1 Interaction Inhibitors through Fluorescence Polarization-Based High-Throughput Screening

Authors: Trong-Nhat Phan, Kyu-Ho Paul Park, David Shum, Joo Hwan No

Journal: Molecules

PubMed ID: 38675653

Doi: 10.3390/molecules29081835

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Synthetic Peptides Selected by Immunoinformatics as Potential Tools for the Specific Diagnosis of Canine Visceral Leishmaniasis

Authors: Gabriel Moreira, Rodrigo Maia, Nathália Soares, Thais Ostolin, Wendel Coura-Vital, Rodrigo Aguiar-Soares, Jeronimo Ruiz, Daniela Resende, Rory de Brito, Alexandre Reis, Bruno Roatt

Journal: Microorganisms

PubMed ID: 38792746

Doi: 10.3390/microorganisms12050906

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Quantitation of Enterovirus A71 Empty and Full Particles by Sedimentation Velocity Analytical Ultracentrifugation

Authors: Anna Yang, Yun Luo, Jie Yang, Tingbo Xie, Wenhui Wang, Xin Wan, Kaiwen Wang, Deqin Pang, Dongsheng Yang, Hanyu Dai, Jie Wu, Shengli Meng, Jing Guo, Zejun Wang, Shuo Shen

Journal: Viruses

PubMed ID: 38675915

Doi: 10.3390/v16040573

Products & Services: Proteins, Expression, Isolation and Analysis

Use of in silico approaches, synthesis and profiling of Pan-filovirus GP-1,2 preprotein specific antibodies

Authors: Maciej Wiśniewski, Peace Babirye, Carol Musubika, Eleni Papakonstantinou, Samuel Kirimunda, Michal Łaźniewski, Teresa Szczepińska, Moses L Joloba, Elias Eliopoulos, Erik Bongcam-Rudloff, Dimitrios Vlachakis, Anup Kumar Halder, Dariusz Plewczyński, Misaki Wayengera

Journal: Brief Funct Genomics

PubMed ID: 38605526

Doi: 10.1093/bfgp/elae012

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Antibody-blocking of a tick transporter impairs Anaplasma phagocytophilum colonization in Haemaphysalis longicornis ticks

Authors: Prachi Namjoshi, Donald M Lubembe, Hameeda Sultana, Girish Neelakanta

Journal: Sci Rep

PubMed ID: 38637614

Doi: 10.1038/s41598-024-59315-w

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Epitope mapping and a candidate vaccine design from canine distemper virus

Authors: Camila Pereira Dos Santos, Jerlane Tarcilia Gomes Telles, Georgia de Freitas Guimarães, Laura Helena Vega Gonzales Gil, Amanda Mota Vieira, Jose Wilton Pinheiro Junior, Carlos Eduardo Calzavara-Silva, Rita de Cássia CarvalhoMaia

Journal: Open Vet J

PubMed ID: 38808294

Doi: 10.5455/OVJ.2024.v14.i4.9

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BRD2-specific inhibitor, BBC0403, inhibits the progression of osteoarthritis pathogenesis in osteoarthritis-induced C57BL/6 male mice

Authors: Hyemi Lee, Jiho Nam, Hahyeong Jang, Young-Sik Park, Min-Hee Son, In-Hyun Lee, Seong-Il Eyun, Jae-Hyun Yang, Jimin Jeon, Siyoung Yang

Journal: Br J Pharmacol

PubMed ID: 38600628

Doi: 10.1111/bph.16359

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Structural basis for the minimal bifunctional alginate epimerase AlgE3 from Azotobacter chroococcum

Authors: Takaaki Fujiwara, Eriko Mano, Eriko Nango

Journal: FEBS Lett

PubMed ID: 38649293

Doi: 10.1002/1873-3468.14886

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The Bifunctional Effects of Lactoferrin (LFcinB11) in Inhibiting Neural Cell Adhesive Molecule (NCAM) Polysialylation and the Release of Neutrophil Extracellular Traps (NETs)

Authors: Bo Lu, Si-Ming Liao, Shi-Jie Liang, Li-Xin Peng, Jian-Xiu Li, Xue-Hui Liu, Ri-Bo Huang, Guo-Ping Zhou

Journal: Int J Mol Sci

PubMed ID: 38731861

Doi: 10.3390/ijms25094641

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Constructing an Antibiotic-Free Protein Expression System for Ovalbumin Biosynthesis in Probiotic Nissle 1917

Authors: Cheng Liu, Xueqin Lv, Long Liu, Jianghua Li, Guocheng Du, Jian Chen, Yanfeng Liu

Journal: J Agric Food Chem

PubMed ID: 38574273

Doi: 10.1021/acs.jafc.4c00827

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Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer's disease by inhibiting neuroinflammation and neuronal necroptosis

Authors: Chong Xu, Yilan Mei, Ruihan Yang, Qiudan Luo, Jienian Zhang, Xiaolin Kou, Jianfeng Hu, Yujie Wang, Yue Li, Rong Chen, Zhengping Zhang, Yuyuan Yao, Jian Sima

Journal: Cell Biosci

PubMed ID: 38678262

Doi: 10.1186/s13578-024-01230-8

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Intratumoural delivery of TRAIL mRNA induces colon cancer cell apoptosis

Authors: Tingxuan Gu, Mengqiao Wang, Xiaorong Fu, Xueli Tian, Juanjuan Bi, Ning Lu, Chen Chen, Shijia Yan, Ang Li, Luyun Wang, Xiang Li, Kangdong Liu, Zigang Dong

Journal: Biomed Pharmacother

PubMed ID: 38636395

Doi: 10.1016/j.biopha.2024.116603

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CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition

Authors: Irene Andreu-Saumell, Alba Rodriguez-Garcia, Vanessa Mühlgrabner, Marta Gimenez-Alejandre, Berta Marzal, Joan Castellsagué, Fara Brasó-Maristany, Hugo Calderon, Laura Angelats, Salut Colell, Mara Nuding, Marta Soria-Castellano, Paula Barbao, Aleix Prat, Alvaro Urbano-Ispizua, Johannes B Huppa, Sonia Guedan

Journal: Nat Commun

PubMed ID: 38670972

Doi: 10.1038/s41467-024-47799-z

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An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin

Authors: Jake A Hill, Yvonne Nyathi, Sam Horrell, David von Stetten, Danny Axford, Robin L Owen, Godfrey S Beddard, Arwen R Pearson, Helen M Ginn, Briony A Yorke

Journal: Commun Chem

PubMed ID: 38600176

Doi: 10.1038/s42004-024-01163-w

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Online monitoring of protein refolding in inclusion body processing using intrinsic fluorescence

Authors: Chika Linda Igwe, Don Fabian Müller, Florian Gisperg, Jan Niklas Pauk, Matthias Kierein, Mohamed Elshazly, Robert Klausser, Julian Kopp, Oliver Spadiut, Eva Přáda Brichtová

Journal: Anal Bioanal Chem

PubMed ID: 38573344

Doi: 10.1007/s00216-024-05249-1

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Immunometric and functional measurement of endogenous vasoinhibin in human sera

Authors: Magdalena Zamora, David Harris, Nils Davies, Johannes Ebnet, Peter Radermacher, Cosima Brucker, Christiane Waller, Juan Pablo Robles, Thomas Bertsch, Carmen Clapp, Jakob Triebel

Journal: Front Endocrinol (Lausanne)

PubMed ID: 38742198

Doi: 10.3389/fendo.2024.1345996

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The Female-Biased General Odorant Binding Protein 2 of Displays Binding Affinity for Biologically Active Host Plant Volatiles

Authors: Jingjing Tu, Zehua Wang, Fan Yang, Han Liu, Guanghang Qiao, Aihuan Zhang, Shanning Wang

Journal: Biology (Basel)

PubMed ID: 38666886

Doi: 10.3390/biology13040274

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Streptococcus pneumoniae endopeptidase O induces trained immunity and confers protection against various pathogenic infections

Authors: Wenlong Xu, Yuan Yuan, Zhaoche Shu, Ting Guo, Bichen Liu, Jiangming Xiao, Lian Li, Yibin Yin, Xuemei Zhang

Journal: Clin Immunol

PubMed ID: 38663493

Doi: 10.1016/j.clim.2024.110226

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P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by

Authors: Michal Caspi Tal, Paige S Hansen, Haley A Ogasawara, Qingying Feng, Regan F Volk, Brandon Lee, Sara E Casebeer, Grace S Blacker, Maia Shoham, Sarah D Galloway, Anne L Sapiro, Beth Hayes, Laughing Bear Torrez Dulgeroff, Tal Raveh, Venkata Raveendra Pothineni, Hari-Hara Sk Potula, Jayakumar Rajadas, Effie E Bastounis, Seemay Chou, William H Robinson, Jenifer Coburn, Irving L Weissman, Balyn W Zaro

Journal: biorxiv

PubMed ID: 38746193

Doi: 10.1101/2024.04.29.591704

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Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system

Authors: Lijie Guo, Pingping Huang, Zhaoxing Li, Young-Cheul Shin, Purui Yan, Meiling Lu, Meirong Chen, Yibei Xiao

Journal: Nat Chem Biol

PubMed ID: 37932527

Doi: 10.1038/s41589-023-01478-0

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Mechanosensitive channel MscL gating transitions coupling with constriction point shift

Authors: Mingfeng Zhang, Siyang Tang, Xiaomin Wang, Sanhua Fang, Yuezhou Li

Journal: Protein Sci

PubMed ID: 38501596

Doi: 10.1002/pro.4965

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An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial

Authors: Amit Saraf, Rohan Gurjar, Swarnendu Kaviraj, Aishwarya Kulkarni, Durgesh Kumar, Ruta Kulkarni, Rashmi Virkar, Jayashri Krishnan, Anjali Yadav, Ekta Baranwal, Ajay Singh, Arjun Raghuwanshi, Praveen Agarwal, Laxman Savergave, Sanjay Singh; GEMCOVAC-OM Study Investigators

Journal: nature medicine

PubMed ID: 38637636

Doi: 10.1038/s41591-024-02955-2

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Engineering allorejection-resistant CAR-NKT cells from hematopoietic stem cells for off-the-shelf cancer immunotherapy

Authors: Yan-Ruide Li, Yang Zhou 1, Jiaji Yu, Yichen Zhu, Derek Lee, Enbo Zhu, Zhe Li, Yu Jeong Kim, Kuangyi Zhou, Ying Fang, Zibai Lyu, Yuning Chen, Yanxin Tian, Jie Huang, Xinjian Cen, Tiffany Husman, Jae Min Cho, Tzung Hsiai, Jin J Zhou, Pin Wang, Benjamin R Puliafito, Sarah M Larson, Lili Yang

Journal: Molecular Therapy

PubMed ID: 38584391

Doi: 10.1016/j.ymthe.2024.04.005

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AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans

Authors: Lilit Grigoryan, Yupeng Feng, Lorenza Bellusci, Lilin Lai, Bushra Wali, Madison Ellis, Meng Yuan, Prabhu S Arunachalam, Mengyun Hu, Sangeeta Kowli, Sheena Gupta, Sofia Maysel-Auslender, Holden T Maecker, Hady Samaha, Nadine Rouphael, Ian A Wilson, Alberto C Moreno, Mehul S Suthar, Surender Khurana, Stéphane Pillet, Nathalie Charland, Brian J Ward, Bali Pulendran

Journal: Science immunology

PubMed ID: 38579013

Doi: 10.1126/sciimmunol.adi8039

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Dbf4-dependent kinase promotes cell cycle controlled resection of DNA double-strand breaks and repair by homologous recombination

Authors: Lorenzo Galanti, Martina Peritore, Robert Gnügge, Elda Cannavo, Johannes Heipke, Maria Dilia Palumbieri, Barbara Steigenberger, Lorraine S Symington, Petr Cejka, Boris Pfander

Journal: Nature Communications

PubMed ID: 38570537

Doi: 10.1038/s41467-024-46951-z

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CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits

Authors: Annemart Koornneef, Kanika Vanshylla, Gijs Hardenberg, Lucy Rutten, Nika M Strokappe, Jeroen Tolboom, Jessica Vreugdenhil, Karin Feddes-de Boer, Aditya Perkasa, Sven Blokland, Judith A Burger, Wei-Chiao Huang, Jonathan F Lovell, Danielle van Manen, Rogier W Sanders, Roland C Zahn, Hanneke Schuitemaker, Johannes P M Langedijk, Frank Wegmann

Journal: Nature Communications

PubMed ID: 38605096

Doi: 10.1038/s41467-024-47492-1

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