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Calcium and integrin-binding protein 1-like interacting with an integrin α-cytoplasmic domain facilitates cellular immunity in Helicoverpa armigera

Authors: Ming-Ming Zhang, Ling-Ling Luo, Yu Liu, Gui-Jie Wang, Huan-Huan Zheng, Xu-Sheng Liu, Jia-Lin Wang

Journal: Dev Comp Immunol

PubMed ID: 35231466

Doi: 10.1016/j.dci.2022.104379

Products & Services: Recombinant Antibody Expression

IL-9/STAT3/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity

Authors: Liuling Xiao, Xingzhe Ma, Lingqun Ye, Pan Su, Wei Xiong, Enguang Bi, Qiang Wang, Miao Xian, Maojie Yang, Jianfei Qian, Qing Yi

Journal: J Clin Invest

PubMed ID: 35192544

Doi: 10.1172/JCI153247

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TAMpepK Suppresses Metastasis through the Elimination of M2-Like Tumor-Associated Macrophages in Triple-Negative Breast Cancer

Authors: Chanju Lee, Soyoung Kim, Chanmi Jeong, Inhee Cho, Juyeon Jo, Ik-Hwan Han, Hyunsu Bae

Journal: Int J Mol Sci

PubMed ID: 35216272

Doi: 10.3390/ijms23042157

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A genome-wide CRISPR screen identifies HuR as a regulator of apoptosis induced by dsRNA and virus

Authors: Huixin Gao, Yuxia Lin, Changbai Huang, Xiaobo Li, Michael S Diamond, Chao Liu, Rong Zhang, Ping Zhang

Journal: J Cell Sci

PubMed ID: 35112703

Doi: 10.1242/jcs.258855

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WIN site inhibition disrupts a subset of WDR5 function

Authors: Andrew J Siladi, Jing Wang, Andrea C Florian, Lance R Thomas, Joy H Creighton, Brittany K Matlock, David K Flaherty, Shelly L Lorey, Gregory C Howard, Stephen W Fesik, April M Weissmiller, Qi Liu, William P Tansey

Journal: Sci Rep

PubMed ID: 35115608

Doi: 10.1038/s41598-022-05947-9

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TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A

Authors: X Rosa Ma, Mercedes Prudencio, Yuka Koike, Sarat C Vatsavayai, Garam Kim, Fred Harbinski, Adam Briner, Caitlin M Rodriguez, Caiwei Guo, Tetsuya Akiyama, H Broder Schmidt, Beryl B Cummings, David W Wyatt, Katherine Kurylo, Georgiana Miller, Shila Mekhoubad, Nathan Sallee, Gemechu Mekonnen, Laura Ganser, Jack D Rubien, Karen Jansen-West, Casey N Cook, Sarah Pickles, Björn Oskarsson, Neill R Graff-Radford, Bradley F Boeve, David S Knopman, Ronald C Petersen, Dennis W Dickson, James Shorter, Sua Myong, Eric M Green, William W Seeley, Leonard Petrucelli, Aaron D Gitler

Journal: Nature

PubMed ID: 35197626

Doi: 10.1038/s41586-022-04424-7

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In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles

Authors: Fang-Yi Su, Qingyang Henry Zhao, Shreyas N Dahotre, Lena Gamboa, Swapnil Subhash Bawage, Aaron D Silva Trenkle, Ali Zamat, Hathaichanok Phuengkham, Rafi Ahmed, Philip J Santangelo, Gabriel A Kwong

Journal: Sci Adv

PubMed ID: 35196075

Doi: 10.1126/sciadv.abm7950

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Distribution of non-synonymous Vkorc1 mutations in roof rats (Rattus rattus) in France and in Spain - consequences for management

Authors: Marlène Damin-Pernik, Abdessalem Hammed, Ludivine Giraud, Joffrey Goulois, Etienne Benoît, Virginie Lattard

Journal: Pestic Biochem Physiol

PubMed ID: 35430058

Doi: 10.1016/j.pestbp.2022.105052

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A Novel TRIM9 Protein Promotes NF-κB Activation Through Interacting With LvIMD in Shrimp During WSSV Infection

Authors: Mingzhe Sun, Shihao Li, Songjun Jin, Xuechun Li, Jianhai Xiang, Fuhua Li

Journal: Front Immunol

PubMed ID: 35281067

Doi: 10.3389/fimmu.2022.819881

Products & Services: Proteins, Expression, Isolation and Analysis

Non-clinical immunogenicity, biodistribution and toxicology evaluation of a chimpanzee adenovirus-based COVID-19 vaccine in rat and rhesus macaque

Authors: Xuedong Dai, Weijun Zhao, Xin Tong, Wei Liu, Xianhuan Zeng, Xiaohui Duan, Hua Wu, Lili Wang, Zhen Huang, Xinying Tang, Yong Yang

Journal: Arch Toxicol

PubMed ID: 35226134

Doi: 10.1007/s00204-021-03221-x

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SARS-CoV2 variant-specific replicating RNA vaccines protect from disease and pathology and reduce viral shedding following challenge with heterologous SARS-CoV2 variants of concern

Authors: David W Hawman, Kimberly Meade-White, Jacob Archer, Shanna S Leventhal, Drew Wilson, Carl Shaia, Samantha Randall, Amit P Khandhar, Kyle Krieger, Tien-Ying Hsiang, Michael Gale, Peter Berglund, Deborah Heydenburg Fuller, Heinz Feldmann, Jesse Erasmus

Journal: Elife

PubMed ID: 35191378

Doi: 10.7554/eLife.75537

Products & Services: Proteins, Expression, Isolation and Analysis

Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease

Authors: Richard G Lee, Shanti Balasubramaniam, Maike Stentenbach, Tom Kralj, Timothy McCubbin, Benjamin Padman, Janine Smith, Lisa G Riley, Archana Priyadarshi, Liuyu Peng, Madison R Nuske, Richard Webster, Ken Peacock, Philip Roberts, Zornitza Stark, Gabrielle Lemire, Yoko A Ito, Kym M Boycott, Michael T Geraghty, Jan Bert Klinken, Sacha Ferdinandusse, Ying Zhou, Rebecca Walsh, Esteban Marcellin, David R Thorburn, Tony Rosciolli, Janice Fletcher, Oliver Rackham, Frédéric M Vaz, Gavin E Reid, Aleksandra Filipovska

Journal: Hum Mol Genet

PubMed ID: 35147173

Doi: 10.1093/hmg/ddac040

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Functional characterization of tyrosine decarboxylase genes that contribute to acteoside biosynthesis in Rehmannia glutinosa

Authors: Yan Hui Yang, Mu Rong Yang, Jian Yu Zhu, Ke Wei Dong, Yan Jie Yi, Rui Fang Li, Lei Zeng, Chang Fu Zhang

Journal: Planta

PubMed ID: 35147783

Doi: 10.1007/s00425-022-03849-8

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Crp/fnr family protein binds to promoters of atxA and sodmn genes that regulate the expression of exotoxins in Bacillus anthracis

Authors: Divya Goel, Sudhir Kumar, Gopal Krishna Joshi, Prashant Rai, Rakesh Bhatnagar

Journal: Protein Expr Purif

PubMed ID: 35114377

Doi: 10.1016/j.pep.2022.106059

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Genome-wide association study and functional follow-up identifies 14q12 as a candidate risk locus for cervical cancer

Authors: Dhanya Ramachandran, Joe Dennis, Laura Fachal, Peter Schürmann, Kristine Bousset, Fabienne Hülse, Qianqian Mao, Yingying Wang, Matthias Jentschke, Gerd Böhmer, Hans-Georg Strauß, Christine Hirchenhain, Monika Schmidmayr, Florian Müller, Ingo Runnebaum, Alexander Hein, Frederik Stübs, Martin Koch, Matthias Ruebner, Matthias W Beckmann, Peter A Fasching, Alexander Luyten, Matthias Dürst, Peter Hillemanns, Douglas F Easton, Thilo Dörk

Journal: Hum Mol Genet

PubMed ID: 35157032

Doi: 10.1093/hmg/ddac031

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Discovery and Mechanism of Small Molecule Inhibitors Selective for the Chromatin-Binding Domains of Oncogenic UHRF1

Authors: Wallace H Liu, Robert E Miner, Brittany N Albaugh, Gene E Ananiev, Scott A Wildman, John M Denu

Journal: Biochemistry

PubMed ID: 35143176

Doi: 10.1021/acs.biochem.1c00698

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Tetrahymena thermophila granule lattice protein 3 improves solubility of sexual stage malaria antigens expressed in Escherichia coli

Authors: Cengiz Akkale, Donna Marie Cassidy-Hanley, Theodore G Clark

Journal: Protein Expr Purif

PubMed ID: 35134517

Doi: 10.1016/j.pep.2022.106060

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Immunoaffinity monoliths for multiplexed extraction of preterm birth biomarkers from human blood serum in 3D printed microfluidic devices

Authors: Haifa M Almughamsi, Makella K Howell, Samuel R Parry, Joule E Esene, Jacob B Nielsen, Gregory P Nordin, Adam T Woolley

Journal: Analyst

PubMed ID: 35103723

Doi: 10.1039/d1an01365c

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Quantifying Neutralizing Antibodies in Patients with COVID-19 by a Two-Variable Generalized Additive Model

Authors: Kuan-Ting Liu, Yu-Nong Gong, Chung-Guei Huang, Peng-Nien Huang, Kar-Yee Yu, Hou-Chen Lee, Sun-Che Lee, Huan-Jung Chiang, Yu-An Kung, Yueh-Te Lin, Mei-Jen Hsiao, Po-Wei Huang, Sheng-Yu Huang, Hsin-Tai Wu, Chih-Ching Wu, Rei-Lin Kuo, Kuan-Fu Chen, Chuan-Tien Hung, Kasopefoluwa Y Oguntuyo, Christian S Stevens, Shreyas Kowdle, Hsin-Ping Chiu, Benhur Lee, Guang-Wu Chen, Shin-Ru Shih

Journal: mSphere

PubMed ID: 35107336

Doi: 10.1128/msphere.00883-21

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Islet Regeneration and Pancreatic Duct Glands in Human and Experimental Diabetes

Authors: Diletta Overi, Guido Carpino, Marta Moretti, Antonio Franchitto, Lorenzo Nevi, Paolo Onori, Enrico De Smaele, Luca Federici, Daniele Santorelli, Marella Maroder, Lola M Reid, Vincenzo Cardinale, Domenico Alvaro, Eugenio Gaudio

Journal: Front Cell Dev Biol

PubMed ID: 35186929

Doi: 10.3389/fcell.2022.814165

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Impact of Superparamagnetic Iron Oxide Nanoparticles on THP-1 Monocytes and Monocyte-Derived Macrophages

Authors: Christina Polasky, Tim Studt, Ann-Kathrin Steuer, Kristin Loyal, Kerstin Lüdtke-Buzug, Karl-Ludwig Bruchhage, Ralph Pries

Journal: Front Mol Biosci

PubMed ID: 35211509

Doi: 10.3389/fmolb.2022.811116

Products & Services: Proteins, Expression, Isolation and Analysis

A Novel CD3/BCMA Bispecific T-cell Redirecting Antibody for the Treatment of Multiple Myeloma

Authors: Mengshang Xiong, Ruoqi Liu, Xiaomin Lei, Dongmei Fan, Fangzhen Lin, Wei Hao, Xiangfei Yuan, Yuanyuan Yang, Xiaolong Zhang, Zhou Ye, Yang Lu, Yanjun Zhang, Jianxiang Wang, Dongsheng Xiong

Journal: J Immunother

PubMed ID: 34711791

Doi: 10.1097/CJI.0000000000000401

Products & Services: Proteins, Expression, Isolation and Analysis

LncRNA NORAD Mediates the Proliferation and Apoptosis of Diffuse Large-B-Cell Lymphoma via Regulation of miR-345-3p/TRAF6 Axis

Authors: Yang Li, Yuanyuan Lv, Jiangya Wang, Xiuli Zhu, Jian Chen, Wenting Zhang, Chuan Wang, Lian Jiang

Journal: Arch Med Res

PubMed ID: 35164979

Doi: 10.1016/j.arcmed.2022.01.004

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SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria-Infected Persons, Cambodia

Authors: Jessica Manning, Irfan Zaidi, Chanthap Lon, Luz Angela Rosas, Jae-Keun Park, Aiyana Ponce, Jennifer Bohl, Sophana Chea, Maria Karkanitsa, Sokunthea Sreng, Huy Rekol, Char Meng Chour, Dominic Esposito, Jeffery K Taubenberger, Matthew J Memoli, Kaitlyn Sadtler, Patrick E Duffy, Fabiano Oliveira

Journal: Emerg Infect Dis

PubMed ID: 35076009

Doi: 10.3201/eid2802.211725

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The Outer Membrane Lipoprotein Tp0136 Stimulates Human Platelet Activation and Aggregation Through PAR1 to Enhance G/G Signaling

Authors: Qiu-Yan Xu, Yong-Jing Wang, Li-Rong Lin, Li-Li Liu, Tian-Ci Yang

Journal: Front Immunol

PubMed ID: 35296084

Doi: 10.3389/fimmu.2022.818151

Products & Services: Proteins, Expression, Isolation and Analysis

The Secreted Protein PA3611 Promotes Bronchial Epithelial Cell Epithelial-Mesenchymal Transition via Integrin αvβ6-Mediated TGF-β1-Induced p38/NF-κB Pathway Activation

Authors: Lei Shu, Sixia Chen, Shaoqing Lin, Huan Lin, Yan Shao, Jing Yao, Lili Qu, Yunshi Zhang, Xing Liu, Xingran Du, Kaili Deng, Xiaolin Chen, Ganzhu Feng

Journal: Front Microbiol

PubMed ID: 35197937

Doi: 10.3389/fmicb.2021.763749

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Vasoactive Intestinal Peptide Indirectly Elicits Pituitary LH Secretion Independent of GnRH in Female Zebrafish

Authors: Sakura Tanaka, Nilli Zmora, Berta Levavi-Sivan, Yonathan Zohar

Journal: Endocrinology

PubMed ID: 34978328

Doi: 10.1210/endocr/bqab264

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Multilevel interactions between native and ectopic isoprenoid pathways affect global metabolism in rice

Authors: Lucía Pérez, Rui Alves, Laura Perez-Fons, Alfonso Albacete, Gemma Farré, Erika Soto, Ester Vilaprinyó, Cristina Martínez-Andújar, Oriol Basallo, Paul D Fraser, Vicente Medina, Changfu Zhu, Teresa Capell, Paul Christou

Journal: Transgenic Res

PubMed ID: 35201538

Doi: 10.1007/s11248-022-00299-6

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The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging

Authors: Yilin Ying, Xuefei Hu, Peng Han, Aaron Mendez-Bermudez, Serge Bauwens, Rita Eid, Li Tan, Mélanie Pousse, Marie-Joseph Giraud-Panis, Yiming Lu, Eric Gilson, Jing Ye

Journal: Nucleic Acids Res

PubMed ID: 35150283

Doi: 10.1093/nar/gkac065

Products & Services: Proteins, Expression, Isolation and Analysis

Immune Response of Adult Sickle Cell Disease Patients after COVID-19 Vaccination: The Experience of a Greek Center

Authors: Christos Varelas, Eleni Gavriilaki, Ioanna Sakellari, Philippos Klonizakis, Evaggelia-Evdoxia Koravou, Ioanna Christodoulou, Ioulia Mavrikou, Andreas Kourelis, Fani Chatzopoulou, Dimitrios Chatzidimitriou, Tasoula Touloumenidou, Apostolia Papalexandri, Achilles Anagnostopoulos, Efthimia Vlachaki

Journal: J Clin Med

PubMed ID: 35207208

Doi: 10.3390/jcm11040937

A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates

Authors: M Gordon Joyce, Hannah A D King, Ines Elakhal-Naouar, Aslaa Ahmed, Kristina K Peachman, Camila Macedo Cincotta, Caroline Subra, Rita E Chen, Paul V Thomas, Wei-Hung Chen, Rajeshwer S Sankhala, Agnes Hajduczki, Elizabeth J Martinez, Caroline E Peterson, William C Chang, Misook Choe, Clayton Smith, Parker J Lee, Jarrett A Headley, Mekdi G Taddese, Hanne A Elyard, Anthony Cook, Alexander Anderson, Kathryn McGuckin Wuertz, Ming Dong, Isabella Swafford, James Brett Case, Jeffrey R Currier, Kerri G Lal, Sebastian Molnar, Manoj S Nair, Vincent Dussupt, Sharon P Daye, Xiankun Zeng, Erica K Barkei, Hilary M Staples, Kendra Alfson, Ricardo Carrion, Shelly J Krebs, Dominic Paquin-Proulx, Nicos Karasavva, Victoria R Polonis, Linda L Jagodzinski, Mihret F Amare, Sandhya Vasan, Paul T Scott, Yaoxing Huang, David D Ho, Natalia de Val, Michael S Diamond, Mark G Lewis, Mangala Rao, Gary R Matyas, Gregory D Gromowski, Sheila A Peel, Nelson L Michael, Diane L Bolton, Kayvon Modjarrad

Journal: Sci Transl Med

PubMed ID: 34914540

Doi: 10.1126/scitranslmed.abi5735

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Pyruvate:ferredoxin oxidoreductase and low abundant ferredoxins support aerobic photomixotrophic growth in cyanobacteria

Authors: Yingying Wang, Xi Chen, Katharina Spengler, Karoline Terberger, Marko Boehm, Jens Appel, Thomas Barske, Stefan Timm, Natalia Battchikova, Martin Hagemann, Kirstin Gutekunst

Journal: Elife

PubMed ID: 35138247

Doi: 10.7554/eLife.71339

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Antibody-Drug Conjugate Targeting c-Kit for the Treatment of Small Cell Lung Cancer

Authors: Kwang-Hyeok Kim, Jin-Ock Kim, Jeong-Yang Park, Min-Duk Seo, Sang Gyu Park

Journal: Int J Mol Sci

PubMed ID: 35216379

Doi: 10.3390/ijms23042264

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Characterization of gluten-degrading prolyl endoprotease from Thermococcus kodakarensis

Authors: Radhakrishna Shetty, Claus Heiner Bang-Berthelsen, Klaudia Weronika Ciurkot, Mike Vestergaard, Per Mårten Hägglund, Harishchandra S Prakash, Timothy John Hobley

Journal: FEMS Microbiol Lett

PubMed ID: 35038331

Doi: 10.1093/femsle/fnac006

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A truncated CC-NB-ARC gene TaRPP13L1-3D positively regulates powdery mildew resistance in wheat via the RanGAP-WPP complex-mediated nucleocytoplasmic shuttle

Authors: Xiangyu Zhang, Guanghao Wang, Xiaojian Qu, Mengmeng Wang, Huan Guo, Lu Zhang, Tingdong Li, Yajuan Wang, Hong Zhang, Wanquan Ji

Journal: Planta

PubMed ID: 35133503

Doi: 10.1007/s00425-022-03843-0

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Human menstrual blood-derived stem cell transplantation suppresses liver injury in DDC-induced chronic cholestasis

Authors: Ya Yang, Yanfei Chen, Yalei Zhao, Feiyang Ji, Lingjian Zhang, Shima Tang, Sainan Zhang, Qingqing Hu, Zuhong Li, Fen Zhang, Qian Li, Lanjuan Li

Journal: Stem Cell Res Ther

PubMed ID: 35123555

Doi: 10.1186/s13287-022-02734-1

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Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis

Authors: Jingwei Xu, Charles F Ericson, Yun-Wei Lien, Florentine U N Rutaganira, Fabian Eisenstein, Miki Feldmüller, Nicole King, Martin Pilhofer

Journal: Nat Microbiol

PubMed ID: 35165385

Doi: 10.1038/s41564-022-01059-2

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Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells

Authors: Mingzhu Yang, Hanwen Yu, Xiu Yu, Shiqi Liang, Yuanlang Hu, Yuxin Luo, Zsuzsanna Izsvák, Chuanbo Sun, Jichang Wang

Journal: Cell Stem Cell

PubMed ID: 35143761

Doi: 10.1016/j.stem.2022.01.010

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Expressing 2-keto acid pathway enzymes significantly increases photosynthetic isobutanol production

Authors: Hao Xie, Peter Lindblad

Journal: Microb Cell Fact

PubMed ID: 35105340

Doi: 10.1186/s12934-022-01738-z

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ATPase subunits of the 26S proteasome are important for oocyte maturation in the brown planthopper

Authors: Xu Cheng, Wei Wang, Lu Zhang, Rui-Rui Yang, Ya Ma, Yan-Yuan Bao

Journal: Insect Mol Biol

PubMed ID: 35084067

Doi: 10.1111/imb.12761

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Nuclear morphogenesis: forming a heterogeneous nucleus during embryogenesis

Authors: Albert Tsai, Justin Crocker

Journal: Development

PubMed ID: 35142344

Doi: 10.1242/dev.200266

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Microsphere Peptide-Based Immunoassay for the Detection of Recombinant Bovine Somatotropin in Injection Preparations

Authors: Nathalie G E Smits, Toine F H Bovee, Sidharam P Pujari, Leendert A van Ginkel, Michel W F Nielen, Bauke Albada

Journal: Biosensors (Basel)

PubMed ID: 35323408

Doi: 10.3390/bios12030138

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The effects of sulfated secondary bile acids on intestinal barrier function and immune response in an inflammatory human intestinal model

Authors: Benthe van der Lugt, Maartje C P Vos, Mechteld Grootte Bromhaar, Noortje Ijssennagger, Frank Vrieling, Jocelijn Meijerink, Wilma T Steegenga

Journal: Heliyon

PubMed ID: 35169646

Doi: 10.1016/j.heliyon.2022.e08883

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Strategy for Conjugating Oligopeptides to Mesoporous Silica Nanoparticles Using Diazirine-Based Heterobifunctional Linkers

Authors: Md Arif Khan, Ramy W Ghanim, Maelyn R Kiser, Mahsa Moradipour, Dennis T Rogers, John M Littleton, Luke H Bradley, Bert C Lynn, Stephen E Rankin, Barbara L Knutson

Journal: Nanomaterials (Basel)

PubMed ID: 35214937

Doi: 10.3390/nano12040608

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Poor neutralization and rapid decay of antibodies to SARS-CoV-2 variants in vaccinated dialysis patients

Authors: Jessica Bassi, Olivier Giannini, Chiara Silacci-Fregni, Laura Pertusini, Paolo Hitz, Tatiana Terrot, Yves Franzosi, Francesco Muoio, Christian Saliba, Marcel Meury, Exequiel A Dellota, Josh R Dillen, Patrick Hernandez, Nadine Czudnochowski, Elisabetta Cameroni, Nicola Beria, Mariangela Ventresca, Alberto Badellino, Soraya Lavorato-Hadjeres, Elisabetta Lecchi, Tecla Bonora, Matteo Mattiolo, Guido Trinci, Daniela Garzoni, Giuseppe Bonforte, Valentina Forni-Ogna, Davide Giunzioni, Lorenzo Berwert, Ravindra K Gupta, Paolo Ferrari, Alessandro Ceschi, Pietro Cippà, Davide Corti, Antonio Lanzavecchia, Luca Piccoli

Journal: PLoS ONE

PubMed ID: 35143540

Doi: 10.1371/journal.pone.0263328

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Phosphorylation of MdERF17 by MdMPK4 Promotes Apple Fruit Peel Degreening during Light/Dark Transitions

Authors: Shuai Wang, Ting Wang, Qiqi Li, Chen Xu, Ji Tian, Yi Wang, Xinzhong Zhang, Xuefeng Xu, Zhenhai Han, Ting Wu

Journal: Plant Cell

PubMed ID: 35166845

Doi: 10.1093/plcell/koac049

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Postvaccination antibody titres predict protection against COVID-19 in patients with autoimmune diseases: survival analysis in a prospective cohort

Authors: Sakir Ahmed, Pankti Mehta, Aby Paul, S Anu, Somy Cherian, Veena Shenoy, Kaveri K Nalianda, Sanjana Joseph, Anagha Poulose, Padmanabha Shenoy

Journal: Ann Rheum Dis

PubMed ID: 35135831

Doi: 10.1136/annrheumdis-2021-221922

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PDE4D targeting enhances anti-tumor effects of sorafenib in clear cell renal cell carcinoma and attenuates MAPK/ERK signaling in a CRAF-dependent manner

Authors: Minghua Cao, Karol Nawalaniec, Amrendra K Ajay, Yueming Luo, Romana Moench, Yanfei Jin, Sheng Xiao, Li-Li Hsiao, Ana Maria Waaga-Gasser

Journal: Transl Oncol

PubMed ID: 35196602

Doi: 10.1016/j.tranon.2022.101377

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Genome-edited powdery mildew resistance in wheat without growth penalties

Authors: Shengnan Li #, Dexing Lin # , Yunwei Zhang # , Min Deng # , Yongxing Chen , Bin Lv , Boshu Li , Yuan Lei , Yanpeng Wang , Long Zhao , Yueting Liang , Jinxing Liu , Kunling Chen , Zhiyong Liu , Jun Xiao , Jin-Long Qiu , Caixia Gao

Journal: Nature

PubMed ID: 35140403

Doi: 10.1038/s41586-022-04395-9

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Shrimp Plasma MANF Works as an Invertebrate Anti-Inflammatory Factor via a Conserved Receptor Tyrosine Phosphatase

Authors: Kaiwen Luo, Yaohui Chen, Fan Wang

Journal: J Immunol

PubMed ID: 35149533

Doi: 10.4049/jimmunol.2100595

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Effect of gastrointestinal alterations mimicking elderly conditions on in vitro digestion of meat and soy proteins

Authors: Chong Wang, Fan Zhao, Yun Bai, Chunbao Li, Xinglian Xu, Karsten Kristiansen, Guanghong Zhou

Journal: Food chemistry

Doi: 10.1016/j.foodchem.2022.132465

Products & Services: Nucleic Acid Purification & Analysis

p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signaling

Authors: Chao Ma, Yuhan Li, Yanan Zong, Tony Velkov, Chenxi Wang , Xinyu Yang , Ming Zhang, Zhimin Jiang, Haoran Sun, Qi Tong, Honglei Sun , Juan Pu, Munir Iqbal, Jinhua Liu , Chongshan Dai , Yipeng Sun

Journal: PLoS Pathog

PubMed ID: 35180274

Doi: 10.1371/journal.ppat.1010295

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LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland

Authors: Rongze Ma , Difei Gong , Huanyang You , Chongshen Xu , Yunzhe Lu , Gabriele Bergers , Zena Werb , Ophir D Klein , Claudia K Petritsch , Pengfei Lu

Journal: Cell Rep

PubMed ID: 35172155

Doi: 10.1016/j.celrep.2022.110375

Products & Services: Recombinant Proteins

Specific anti-SARS-CoV-2 S1 IgY-scFv is a promising tool for recognition of the virus

Authors: Shikun Ge, Rao Wu, Tingting Zhou, Xiang Liu, Jin Zhu, Xiaoying Zhang

Journal: AMB Express

PubMed ID: 35150368

Doi: 10.1186/s13568-022-01355-4

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Metabolic Division in an Coculture System for Efficient Production of Kaempferide

Authors: Zetian Qiu, Xue Liu, Jia Li, Bin Qiao, Guang-Rong Zhao

Journal: ACS Synth Biol

PubMed ID: 35167258

Doi: 10.1021/acssynbio.1c00510

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Bacterial N4-methylcytosine as an epigenetic mark in eukaryotic DNA

Authors: Fernando Rodriguez, Irina A Yushenova, Daniel DiCorpo, Irina R Arkhipova

Journal: Nat Commun

PubMed ID: 35228526

Doi: 10.1038/s41467-022-28471-w

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Grafting Watermelon Onto Pumpkin Increases Chilling Tolerance by Up Regulating to Increase Putrescine Biosynthesis

Authors: Junyang Lu, Fei Cheng, Yuan Huang, Zhilong Bie

Journal: Front Plant Sci

PubMed ID: 35242149

Doi: 10.3389/fpls.2021.812396

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The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature

Authors: Galen J Correy, Daniel W Kneller, Gwyndalyn Phillips, Swati Pant, Silvia Russi, Aina E Cohen, George Meigs, James M Holton, Stefan Gahbauer, Michael C Thompson, Alan Ashworth, Leighton Coates, Andrey Kovalevsky, Flora Meilleur, James S Fraser

Journal: biorxiv

PubMed ID: 35169801

Doi: 10.1101/2022.02.07.479477

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and evaluation of imatinib as an inhibitor for SARS-CoV-2

Authors: Nirmitee Mulgaonkar, Haoqi Wang, Samavath Mallawarachchi, Daniel Růžek, Byron Martina, Sandun Fernando

Journal: J Biomol Struct Dyn

PubMed ID: 35220926

Doi: 10.1080/07391102.2022.2045221

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Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761

Authors: Lingling Xu, Yinling Tan, Fengxia Xu, Yong Zhang

Journal: Bioengineered

PubMed ID: 35030964

Doi: 10.1080/21655979.2021.2019872

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membrane vesicles cause endothelial barrier failure and lung injury

Authors: Mark J McVey, Mazharul Maishan, Anna Foley, Razan Turki, Elyse J Roach, Rose Deschler, Sarah Weidenfeld, Neil M Goldenberg, Cezar M Khursigara, Wolfgang M Kuebler

Journal: Eur Respir J

PubMed ID: 35169027

Doi: 10.1183/13993003.01500-2021

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NR3C2 suppresses the proliferation, migration, invasion and angiogenesis of colon cancer cells by inhibiting the AKT/ERK signaling pathway

Authors: Jia Li, Zhao Xu

Journal: Mol Med Rep

PubMed ID: 35191517

Doi: 10.3892/mmr.2022.12649

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Islet Regeneration and Pancreatic Duct Glands in Human and Experimental Diabetes

Journal: Front Cell Dev Biol

PubMed ID: 35186929

Doi: 10.3389/fcell.2022.814165

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An insect antifreeze protein from Anatolica polita enhances the cryoprotection of Xenopus laevis eggs and embryos

Authors: Predrag Jevtić, K Wade Elliott, Shelby E Watkins, Jonathan A Sreter, Katarina Jovic, Ian B Lehner, Paul W Baures, John G Tsavalas, Daniel L Levy, Krisztina Varga

Journal: J Exp Biol

PubMed ID: 35014670

Doi: 10.1242/jeb.243662

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Enhanced transglycosylation activity of an Endo-F3 mutant by ligand-directed localization

Authors: Xiangman Zou, Zhi Liu, Liya Liu, Wei Shi, Wanzhen Li, Zifen Guo, Feng Tang, Wei Huang

Journal: Org Biomol Chem

PubMed ID: 35166761

Doi: 10.1039/d2ob00030j

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Backbone NMR resonance assignment of the intrinsically disordered UBact protein from Nitrospira nitrosa

Authors: Steven M Bonn, David Fushman

Journal: Biomol NMR Assign

PubMed ID: 35107780

Doi: 10.1007/s12104-022-10070-x

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Development and validation of an LC-MS/MS based quantitative assay for marmoset insulin in serum

Authors: Robinson W Goy, Hemanta K Shrestha, Ricki J Colman, Natalie J Dukes, Toni E Ziegler, Amita Kapoor

Journal: J Chromatogr B Analyt Technol Biomed Life Sci

PubMed ID: 35247678

Doi: 10.1016/j.jchromb.2022.123150

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Development and validation of an LC-MS/MS based quantitative assay for marmoset insulin in serum

Authors: Robinson W Goy, Hemanta K Shrestha, Ricki J Colman, Natalie J Dukes, Toni E Ziegler, Amita Kapoor

Journal: J Chromatogr B Analyt Technol Biomed Life Sci

PubMed ID: 35247678

Doi: 10.1016/j.jchromb.2022.123150

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Physiological ROS controls Upd3-dependent modeling of ECM to support cardiac function in

Authors: Jayati Gera, Prerna Budakoti, Meghna Suhag, Lolitika Mandal, Sudip Mandal

Journal: Sci Adv

PubMed ID: 35179958

Doi: 10.1126/sciadv.abj4991

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Distinct impact of DMARD combination and monotherapy in immunogenicity of an inactivated SARS-CoV-2 vaccine in rheumatoid arthritis

Authors: Ana Cristina Medeiros-Ribeiro, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Henrique Carriço da Silva, Carla G S Saad, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Carlo Scognamiglio Renner Araujo, Tatiane Lie Nakai, Clóvis Artur Silva, Tatiana Pedrosa, Léonard de Vinci Kanda Kupa, Matheus Santos Rodrigues Silva, Guilherme Guimarães Moreira Balbi, Esper Georges Kallas, Nádia Emi Aikawa, Eloisa Bonfa

Journal: Ann Rheum Dis

PubMed ID: 35135832

Doi: 10.1136/annrheumdis-2021-221735

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CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

Authors: Yiru Long , Jianhua Sun , Tian-Zhang Song , Tingting Liu , Feng Tang , Xinxin Zhang, Longfei Ding , Yunqiu Miao , Weiliang Zhu , Xiaoyan Pan , Qi An, Mian Qin , Xiankun Tong , Xionghua Peng , Pan Yu, Peng Zhu , Jianqing Xu , Xiaoyan Zhang , Yachun Zhang , Datao Liu, Ben Chen , Huilin Chen , Leike Zhang , Gengfu Xiao, Jianping Zuo , Wei Tang , Ji Zhou, Heng Li , Zhijian Xu, Hong-Yi Zheng , Xin-Yan Long , Qiuping Qin , Yong Gan , Jin Ren , Wei Huang , Yong-Tang Zheng , Guangyi Jin , Likun Gong

Journal: Cell Discov .

PubMed ID: 35102138

Doi: 10.1038/s41421-021-00370-2

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Vaccination Strategies at a COVID-19 Mass Vaccination Site

Authors: Sheng-Huang Hsiao, Sheng-Jean Huang, Chiao-Yu Huang

Journal: Int J Health Policy Manag

PubMed ID: 35247942

Doi: 10.34172/ijhpm.2022.6881

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CoronaVac and ChAdOx1 Vaccination and Gamma Infection Elicited Neutralizing Antibodies against the SARS-CoV-2 Delta Variant

Authors: Marcilio Jorge Fumagalli, Luiza Antunes Castro-Jorge, William Marciel de Souza, Patrick Orestes de Azevedo, Alana Witt Hansen, Ricardo Tostes Gazzinelli, Benedito Antônio Lopes da Fonseca, Fernando Rosado Spilki, Luiz Tadeu Moraes Figueiredo

Journal: Viruses

PubMed ID: 35215895

Doi: 10.3390/v14020305

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Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation

Authors: Leena Halim, Kushal K Das, Daniel Larcombe-Young, Adam Ajina, Andrea Candelli, Reuben Benjamin, Richard Dillon, David M Davies, John Maher

Journal: Front Immunol

PubMed ID: 35222427

Doi: 10.3389/fimmu.2022.836549

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Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance

Authors: Xiaorong Chen, Noah P Bradley, Wei Lu, Katherine L Wahl, Mei Zhang, Hua Yuan, Xian-Feng Hou, Brandt F Eichman, Gong-Li Tang

Journal: Nucleic Acids Res

PubMed ID: 35191495

Doi: 10.1093/nar/gkac085

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The suppressor of copper sensitivity protein C from Caulobacter crescentus is a trimeric disulfide isomerase that binds copper(I) with subpicomolar affinity

Authors: Guillaume A Petit, Yaoqin Hong, Karrera Y Djoko, Andrew E Whitten, Emily J Furlong, Airlie J McCoy, Jacqueline M Gulbis, Makrina Totsika, Jennifer L Martin, Maria A Halili

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35234148

Doi: 10.1107/S2059798322000729

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Bioinformatic characterization of a triacylglycerol lipase produced by isolated from the decaying seed of

Authors: Benjamin O Ezema, Kingsley O Omeje, Roslyn M Bill, Alan D Goddard, Sabinus Oscar O Eze, Alfred Fernandez-Castane

Journal: J Biomol Struct Dyn

PubMed ID: 35147487

Doi: 10.1080/07391102.2022.2035821

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OmpA may be used as a novel target to enrich and detect Escherichia coli in milk samples

Authors: Yichen Tian, Kaiqing Yang, Yaoqiang Shi, Jinyang Zhang, Qinqin Han, Xueshan Xia, Yuzhu Song

Journal: J Dairy Sci

PubMed ID: 35151480

Doi: 10.3168/jds.2021-20974

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Crystal packing reveals rapamycin-mediated homodimerization of an FK506-binding domain

Authors: Ajit Kumar Singh, Ketul Saharan, Somanath Baral, Sheng Luan, Dileep Vasudevan

Journal: Int J Biol Macromol

PubMed ID: 35218805

Doi: 10.1016/j.ijbiomac.2022.02.107

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The Anticancer Effect of a Conjugated Antimicrobial Peptide Against Colorectal Cancer (CRC) Cells

Authors: Raed Obaid Saleh, Ihsan Naji Atiyah Essia, Saade Abdalkareem Jasim

Journal: J Gastrointest Cancer

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A self-assembling nanoparticle vaccine targeting the conserved epitope of influenza virus hemagglutinin stem elicits a cross-protective immune response

Authors: Yongbo Qiao, Shuang Li, Shenghui Jin, Yi Pan, Yuhua Shi, Wei Kong, Yaming Shan

Journal: Nanoscale

PubMed ID: 35157751

Doi: 10.1039/d1nr08460g

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Microparticles from Hyperphosphatemia-Stimulated Endothelial Cells Promote Vascular Calcification Through Astrocyte-Elevated Gene-1

Authors: Yazhou Xiang, Yingjie Duan, Zhong Peng, Hong Huang, Wenjun Ding, En Chen, Zilong Liu, Chengyun Dou, Jianlong Li, Jihong Ou, Qingsong Wan, Bo Yang, Zhangxiu He

Journal: Calcif Tissue Int

PubMed ID: 35195734

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Synthesis and identification of lithocholic acid 3-sulfate as RORγt ligand to inhibit Th17 cell differentiation

Authors: Riping Xiao, Kawai Lei, Hioha Kuok, Wende Deng, Yuxin Zhuang, Yanqing Tang, Zhengyang Guo, Hongyan Qin, Li-Ping Bai, Ting Li

Journal: J Leukoc Biol

PubMed ID: 35188700

Doi: 10.1002/JLB.1MA0122-513R

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Aqueous Extract of Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway

Authors: Shushu Qian, Xuan Han, Xiaocao Sha, Fang Tian, Hong Huang, Pengjun Jiang, Guoshun Huang, Bangyun Ma, Hong Zhang, Yiye Zhu, Xuemei Sun

Journal: J Inflamm Res

PubMed ID: 35210810

Doi: 10.2147/JIR.S345497

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orter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor

Authors: Chan Zou, Jordan A Beard, Guoping Yang, William E Evans, Erik J Bonten

Journal: J Inflamm Res

PubMed ID: 35221708

Doi: 10.2147/JIR.S333725

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High density lipoprotein nanoparticle as delivery system for radio-sensitising miRNA: An investigation in 2D/3D head and neck cancer models

Authors: Pouya Dehghankelishadi, Michelle F Maritz, Parisa Badiee, Benjamin Thierry

Journal: Int J Pharm

PubMed ID: 35176332

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A machine learning approach-based array sensor for rapidly predicting the mechanisms of action of antibacterial compounds

Authors: Zhijun Li, Kun Jin, Hong Chen, Liyuan Zhang, Guitao Zhang, Yizhou Jiang, Haixia Zou, Wentao Wang, Guangpei Qi, Xiangmeng Qu

Journal: Nanoscale

PubMed ID: 35167631

Doi: 10.1039/d1nr07452k

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Development of SARS-CoV-2 variant protein microarray for profiling humoral immunity in vaccinated subjects

Authors: Tzong-Shiann Ho, Pin-Xian Du, Wen-Yu Su, Harvey M Santos, Ya-Lan Lin, Yi-Yu Chou, Batuhan Birol Keskin, Chi Ho Pau, Guan-Da Syu

Journal: Biosens Bioelectron

PubMed ID: 35168024

Doi: 10.1016/j.bios.2022.114067

The small DdrR protein directly interacts with the UmuDAb regulator of the mutagenic DNA damage response in

Authors: Anja Pavlin, Gregor Bajc, Nadine Fornelos, Douglas F Browning, Matej Butala

Journal: J Bacteriol

PubMed ID: 35191762

Doi: 10.1128/jb.00601-21

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Occludin Promotes Adhesion of CD8 T Cells and Melanocytes in Vitiligo via the HIF-1 Signaling Pathway

Authors: Puyu Zou, Yangfan Xiao, Qiancheng Deng, Yaqian Shi, Ruixuan You, Zixin Pi, Jiani Liu, Yi Zhan, Qinghai Zeng, Zhuotong Zeng, Rong Xiao

Journal: Oxid Med Cell Longev

PubMed ID: 35222802

Doi: 10.1155/2022/6732972

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Occludin Promotes Adhesion of CD8 T Cells and Melanocytes in Vitiligo via the HIF-1 Signaling Pathway

Authors: Puyu Zou, Yangfan Xiao, Qiancheng Deng, Yaqian Shi, Ruixuan You, Zixin Pi, Jiani Liu, Yi Zhan, Qinghai Zeng, Zhuotong Zeng, Rong Xiao

Journal: Oxid Med Cell Longev

PubMed ID: 35222802

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FXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway

Authors: Licheng Ding, Jie Li

Journal: Bioengineered

PubMed ID: 35042436

Doi: 10.1080/21655979.2021.2023795

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Identification and mapping of post-transcriptional modifications on the HIV-1 antisense transcript Ast in human cells

Authors: Mariana Estevez, Rui Li, Biplab Paul, Kaveh Daneshvar, Alan C Mullen, Fabio Romerio, Balasubrahmanyam Addepalli

Journal: RNA

PubMed ID: 35168996

Doi: 10.1261/rna.079043.121

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The small DdrR protein directly interacts with the UmuDAb regulator of the mutagenic DNA damage response in

Authors: Anja Pavlin, Gregor Bajc, Nadine Fornelos, Douglas F Browning, Matej Butala

Journal: J Bacteriol

PubMed ID: 35191762

Doi: 10.1128/jb.00601-21

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Identification and Characterization of a Set of Monocot BAHD Monolignol Transferases

Authors: Rebecca A Smith, Emily T Beebe, Craig A Bingman, Kirk Vander Meulen, Alexis Eugene, Alexander J Steiner, Steven D Karlen, John Ralph, Brian G Fox

Journal: Plant Physiol

PubMed ID: 35134228

Doi: 10.1093/plphys/kiac035

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Identification and Characterization of a Set of Monocot BAHD Monolignol Transferases

Authors: Rebecca A Smith, Emily T Beebe, Craig A Bingman, Kirk Vander Meulen, Alexis Eugene, Alexander J Steiner, Steven D Karlen, John Ralph, Brian G Fox

Journal: Plant Physiol

PubMed ID: 35134228

Doi: 10.1093/plphys/kiac035

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Lanthanide-based β-Tricalcium Phosphate Upconversion Nanoparticles as an Effective Theranostic Nonviral Vectors for Image-Guided Gene Therapy

Authors: Flavia Rodrigues Oliveira Silva, Nelson Batista Lima, Maria Helena Bellini, Luiz Felipe Silva Teixeira, Eric Yiwei Du, Niloufar Jamshidi, Justin Gooding, Adam David Martin, Alexander Macmillan, Christopher Peter Marquis, Pall Thordarson

Journal: Nanotheranostics

PubMed ID: 35223382

Doi: 10.7150/ntno.68789

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Rapid screening of aptamers for fluorescent targets by integrated digital PCR and flow cytometry

Authors: Xiaona Fang, Wenjing Li, Tian Gao, Qurat Ul Ain Zahra, Zhaofeng Luo, Renjun Pei

Journal: Talanta

PubMed ID: 35180537

Doi: 10.1016/j.talanta.2022.123302

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Transformation of by for the Expression of the Hemagglutinin of Avian Influenza Virus H5

Authors: Inkar Castellanos-Huerta, Gabriela Gómez-Verduzco, Guillermo Tellez-Isaias, Guadalupe Ayora-Talavera, Bernardo Bañuelos-Hernández, Víctor Manuel Petrone-García, Gilberto Velázquez-Juárez, Isidro Fernández-Siurob

Journal: Microorganisms

PubMed ID: 35208815

Doi: 10.3390/microorganisms10020361

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Aluminum nanoparticles deliver a dual-epitope peptide for enhanced anti-tumor immunotherapy

Authors: Shuting Bai, Hao Jiang, Yuanshuai Song, Yining Zhu, Ming Qin, Chunting He, Guangsheng Du, Xun Sun

Journal: J Control Release

PubMed ID: 35217098

Doi: 10.1016/j.jconrel.2022.02.027

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