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Ultrasensitive fluorometric oligonucleotide immunoassay for the simultaneous and efficient detection of two mycotoxins in agricultural products

Authors: Ming Li, Chenfei Han, Chuqin Yang, Mingna Sun, Jinsheng Duan, Xuchun Qiu, Daolin Du

Journal: Anal Methods

PubMed ID: 35583257

Doi: 10.1039/d2ay00367h

Products & Services: Custom DNA/RNA Oligos

Histidine Ligated Iron-Sulfur Peptides

Authors: Luca Valer, Daniele Rossetto, Taylor Parkkila, Lorenzo Sebastianelli, Graziano Guella, Amber L Hendricks, James A Cowan, Lingzi Sang, Sheref S Mansy

Journal: Chembiochem

PubMed ID: 35674331

Doi: 10.1002/cbic.202200202

Products & Services: Plasmid DNA Preparation

Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease

Authors: Nikhil Panicker, Tae-In Kam, Hu Wang, Stewart Neifert, Shih-Ching Chou, Manoj Kumar, Saurav Brahmachari, Aanishaa Jhaldiyal, Jared T Hinkle, Fatih Akkentli, Xiaobo Mao, Enquan Xu, Senthilkumar S Karuppagounder, Eric T Hsu, Sung-Ung Kang, Olga Pletnikova, Juan Troncoso, Valina L Dawson, Ted M Dawson

Journal: Neuron

PubMed ID: 35654037

Doi: 10.1016/j.neuron.2022.05.009

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Rnd3 Expression is Necessary to Maintain Mitochondrial Homeostasis but Dispensable for Autophagy

Authors: Cristina Cueto-Ureña, Enric Mocholí, Josep Escrivá-Fernández, Susana González-Granero, Sabina Sánchez-Hernández, Amalia Solana-Orts, Begoña Ballester-Lurbe, Karim Benabdellah, Rosa M Guasch, José Manuel García-Verdugo, Francisco Martín, Paul J Coffer, Ignacio Pérez-Roger, Enric Poch

Journal: Front Cell Dev Biol

PubMed ID: 35832788

Doi: 10.3389/fcell.2022.834561

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The Effects of Qinghao-Kushen and Its Active Compounds on the Biological Characteristics of Liver Cancer Cells

Authors: Jingmin Ji, Zhiqin Zhang, Qing Peng, Liyuan Hao, Yinglin Guo, Yu Xue, Yiwei Liu, Caige Li, Xinli Shi

Journal: Evid Based Complement Alternat Med

PubMed ID: 35722140

Doi: 10.1155/2022/8763510

Products & Services: Monoclonal Antibody Services

Towards a general approach for tailoring the hydrophobic binding site of phenylalanine ammonia-lyases

Authors: Souad Diana Tork, Mădălina Elena Moisă, Lilla Cserepes, Alina Filip, Levente Csaba Nagy, Florin Dan Irimie, László Csaba Bencze

Journal: Sci Rep

PubMed ID: 35739148

Doi: 10.1038/s41598-022-14585-0

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Deletion of COM donor and acceptor domains and the interaction between modules in bacillomycin D produced by

Authors: Ziyan Lv, Wenjie Ma, Ping Zhang, Zhaoxin Lu, Libang Zhou, Fanqiang Meng, Zuwei Wang, Xiaomei Bie

Journal: Synth Syst Biotechnol

PubMed ID: 35782484

Doi: 10.1016/j.synbio.2022.05.007

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Altered gut microbiota and metabolites profile are associated with reduced bone metabolism in ethanol-induced osteoporosis

Authors: Zhao Liu, Xilin Xu, Yiwei Shen, Yuanyuan Hao, Wenwen Cui, Wenyan Li, Xin Zhang, Hang Lv, Xiaodong Li, Yunlong Hou, Xiaofeng Zhang

Journal: Cell Prolif

PubMed ID: 35688648

Doi: 10.1111/cpr.13245

Products & Services: Protein and Antibody Isolation

mRNA Booster Vaccination Enhances Antibody Responses against SARS-CoV2 Omicron Variant in Individuals Primed with mRNA or Inactivated Virus Vaccines

Authors: Biyan Zhang, Jianxin Huo, Yuhan Huang, Shuan Yong Teo, Kaibo Duan, Yanfeng Li, Lim Kai Toh, Kong Peng Lam, Shengli Xu

Journal: Vaccines (Basel)

PubMed ID: 35891221

Doi: 10.3390/vaccines10071057

RNA Polymerase II Transcription in : TFIIB from Can Replace the Transcriptional Functions of Fission Yeast TFIIB In Vivo and In Vitro

Authors: Diego A Rojas, Fabiola Urbina, Aldo Solari, Edio Maldonado

Journal: Int J Mol Sci

PubMed ID: 35743306

Doi: 10.3390/ijms23126865

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Dynamic transcriptome profiling reveals essential roles of the receptor tyrosine kinases (RTK) family in feather development of duck

Authors: H Liu, Q Xu, Y Xi, S Ma, J Wang, L Bai, C Han, H He, L Li

Journal: Br Poult Sci

PubMed ID: 35383522

Doi: 10.1080/00071668.2022.2061839

Products & Services: Protein and Antibody Isolation

Immunological characteristics of MAV/06 strain of varicella-zoster virus vaccine in an animal model

Authors: Duckhyang Shin, Younchul Shin, Eunmi Kim, Hyojung Nam, Haiyan Nan, Jaewoo Lee

Journal: BMC Immunol

PubMed ID: 35658899

Doi: 10.1186/s12865-022-00503-6

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The optimal docking strength for reversibly tethered kinases

Authors: Mateusz Dyla, Nicolás S González Foutel, Daniel E Otzen, Magnus Kjaergaard

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35696590

Doi: 10.1073/pnas.2203098119

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The humoral immune response more than one year after SARS-CoV-2 infection: low detection rate of anti-nucleocapsid antibodies via Euroimmun ELISA

Authors: Gregor Paul, Philipp Strnad, Oliver Wienand, Ursula Krause, Thomas Plecko, Anja Effenberger-Klein, Katrin Elisabeth Giel, Florian Junne, Annette Galante-Gottschalk, Stefan Ehehalt, Jan Steffen Jürgensen

Journal: Infection

PubMed ID: 35648370

Doi: 10.1007/s15010-022-01830-x

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Bioinformatics-Driven Identification of p62 as A Crucial Oncogene in Liver Cancer

Authors: Ling Wang, Culton R Hensley, Mary E Howell, Shunbin Ning

Journal: Front Oncol

PubMed ID: 35814476

Doi: 10.3389/fonc.2022.923009

Products & Services: Catalog Gene Editing

Assembly checkpoint of the proteasome regulatory particle is activated by coordinated actions of proteasomal ATPase chaperones

Authors: Asrafun Nahar, Vladyslava Sokolova, Suganya Sekaran, James D Orth, Soyeon Park

Journal: Cell Reports

PubMed ID: 35675778

Doi: 10.1016/j.celrep.2022.110918

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Pre-existing immunity modulates responses to mRNA boosters

Authors: Tanushree Dangi, Sarah Sanchez, Min Han Lew, Lavanya Visvabharathy, Justin Richner, Igor J Koralnik, Pablo Penaloza-MacMaster

Journal: biorxiv

PubMed ID: 35794898

Doi: 10.1101/2022.06.27.497248

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Tailored protein-conjugated DNA nanoplatform for synergistic cancer therapy

Authors: Dingkang Liu, Ye Chen, Qun Wang, Yue Ji, Lichen Bao, Wenbing Yao, Xiangdong Gao, Jun Yin

Journal: Journal of controlled release

PubMed ID: 35452765

Doi: 10.1016/j.jconrel.2022.04.022

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Structural and mechanistic insights into the inhibition of type I-F CRISPR-Cas system by anti-CRISPR protein AcrIF23

Authors: Junhui Ren, Hao Wang, Lingguang Yang, Feixue Li, Yao Wu, Zhipu Luo, Zeliang Chen, Yi Zhang, Yue Feng

Journal: J Biol Chem

PubMed ID: 35697070

Doi: 10.1016/j.jbc.2022.102124

Products & Services: Mutant Libraries

Immunoinformatics Aided Design and Validation of a Cross-Reactive Peptide Based Multi-Epitope Vaccine Targeting Multiple Serotypes of Dengue Virus

Authors: Vikas Kaushik, Sunil Krishnan G, Lovi Raj Gupta, Utkarsh Kalra, Abdul Rajjak Shaikh, Luigi Cavallo, Mohit Chawla

Journal: Front Immunol

PubMed ID: 35799781

Doi: 10.3389/fimmu.2022.865180

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Recombinant Carrying Endostatin Protein Alleviates Dextran Sodium Sulfate-Induced Colitis and Colon Cancer in Rats

Authors: Zhiqian Bi, Enqing Cui, Yingying Yao, Xiaoyao Chang, Xiaoyang Wang, Yuhui Zhang, Gen-Xing Xu, Hongqin Zhuang, Zi-Chun Hua

Journal: Front Microbiol

PubMed ID: 35847065

Doi: 10.3389/fmicb.2022.927277

Products & Services: Mammalian Expression

CRISPR/CasRx-Mediated RNA Knockdown Reveals That ACE2 Is Involved in the Regulation of Oligodendroglial Cell Morphological Differentiation

Authors: Yukino Kato, Kenji Tago, Shoya Fukatsu, Miyu Okabe, Remina Shirai, Hiroaki Oizumi, Katsuya Ohbuchi, Masahiro Yamamoto, Kazushige Mizoguchi, Yuki Miyamoto, Junji Yamauchi

Journal: Noncoding RNA

PubMed ID: 35736639

Doi: 10.3390/ncrna8030042

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Long Intergenic Noncoding RNA MIAT as a Regulator of Human Th17 Cell Differentiation

Authors: Mohd Moin Khan, Meraj Hasan Khan, Ubaid Ullah Kalim, Sofia Khan, Sini Junttila, Niklas Paulin, Lingjia Kong, Omid Rasool, Laura L Elo, Riitta Lahesmaa

Journal: Front Immunol

PubMed ID: 35784351

Doi: 10.3389/fimmu.2022.856762

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Lipases secreted by a gut bacterium inhibit arbovirus transmission in mosquitoes

Authors: Xi Yu, Liangqin Tong, Liming Zhang, Yun Yang, Xiaoping Xiao, Yibin Zhu, Penghua Wang, Gong Cheng

Journal: PLoS Pathog

PubMed ID: 35679229

Doi: 10.1371/journal.ppat.1010552

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PBP1 plays key roles in sex pheromone reception of the fall armyworm

Authors: Yongzhi Zhong, Minghui Xie, Zhongjuan Di, Fengqi Li, Jiaqi Chen, Xiangxin Kong, Lulu Lin, Weihua Su, Lina Xu, Feng Zhang, Rui Tang, Haoliang Chen

Journal: Int J Biol Macromol

PubMed ID: 35709868

Doi: 10.1016/j.ijbiomac.2022.06.068

Products & Services: Protein and Antibody Isolation

Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT

Authors: Xuefang Pan, Mahsa Taherzadeh, Poulomee Bose, Rachel Heon-Roberts, Annie L A Nguyen, TianMeng Xu, Camila Pará, Yojiro Yamanaka, David A Priestman, Frances M Platt, Shaukat Khan, Nidhi Fnu, Shunji Tomatsu, Carlos R Morales, Alexey V Pshezhetsky

Journal: J Exp Med

PubMed ID: 35704026

Doi: 10.1084/jem.20211860

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Role of PIM2 in acute lung injury induced by sepsis

Authors: Juncai Ding, Xiufang Yang, Huijuan Huang, Bo Wang

Journal: Exp Ther Med

PubMed ID: 35978927

Doi: 10.3892/etm.2022.11480

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ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia

Authors: Linjiang Lao, Isabelle Bourdeau, Lucia Gagliardi, Xiao He, Wei Shi, Bingbing Hao, Minjia Tan, Yan Hu, Junzheng Peng, Benoit Coulombe, David J Torpy, Hamish S Scott, Andre Lacroix, Hongyu Luo, Jiangping Wu

Journal: Nucleic Acids Res

PubMed ID: 35687106

Doi: 10.1093/nar/gkac483

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LncRNA LEMD1-AS1 relieves chondrocyte inflammation by targeting miR-944/PGAP1 in osteoarthritis

Authors: Haitao Li, Kaihua Lian, Jianguang Mao, Fuguo Huang, Chunli Zhang, Jianguo Zang

Journal: Cell Cycle

PubMed ID: 35686740

Doi: 10.1080/15384101.2022.2084294

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A structural vaccinology approach for in silico designing of a potential self-assembled nanovaccine against Leishmania infantum

Authors: Bahareh Vakili, Navid Nezafat, Manica Negahdaripour, Younes Ghasemi

Journal: Exp Parasitol

PubMed ID: 35709889

Doi: 10.1016/j.exppara.2022.108295

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Phosphorylation of serine residues S252, S268/S269, and S879 in p120 catenin activates migration of presomitic mesoderm in gastrulating zebrafish embryos

Authors: Ariana Kupai, Hiroko Nakahara, Kathleen M Voss, Matthew S Hirano, Alexis Rodriguez, Donna L Lackey, James F Murayama, Chase J Mathieson, Botao Shan, Emma C Horton, Grace H Curtis, Joyce Huang, Merrill B Hille

Journal: Dev Dyn

PubMed ID: 35706088

Doi: 10.1002/dvdy.508

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bFGF-Loaded Mesoporous Silica Nanoparticles Promote Bone Regeneration Through the Wnt/β-Catenin Signalling Pathway

Authors: Mingkui Shen, Lulu Wang, Li Feng, Yi Gao, Sijing Li, Yulan Wu, Chuangye Xu, Guoxian Pei

Journal: Int J Nanomedicine

PubMed ID: 35698561

Doi: 10.2147/IJN.S366926

Products & Services: Protein and Antibody Isolation

Potentiating adoptive cell therapy using synthetic IL-9 receptors

Authors: Anusha Kalbasi, Mikko Siurala, Leon L Su, Mito Tariveranmoshabad, Lora K Picton, Pranali Ravikumar, Peng Li, Jian-Xin Lin, Helena Escuin-Ordinas, Tong Da, Sarah V Kremer, Amy L Sun, Sofia Castelli, Sangya Agarwal, John Scholler, Decheng Song, Philipp C Rommel, Enrico Radaelli, Regina M Young, Warren J Leonard, Antoni Ribas, Carl H June, K Christopher Garcia

Journal: Nature

PubMed ID: 35676488

Doi: 10.1038/s41586-022-04801-2

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Cross-Reactivity of IgG Antibodies and Virus Neutralization in mRNA-Vaccinated People Against Wild-Type SARS-CoV-2 and the Five Most Common SARS-CoV-2 Variants of Concern

Authors: Mandy Schwarze, Andor Krizsan, Alexandra Brakel, Fabian Pohl, Daniela Volke, Ralf Hoffmann

Journal: Front Immunol

PubMed ID: 35784285

Doi: 10.3389/fimmu.2022.915034

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Immunogenicity of candidate SARS-CoV-2 DNA vaccines based on the spike protein

Authors: Heeji Lim, Se Eun Kim, Yun Ha Lee, Yun-Ho Hwang, Su Hwan Kim, Mi Young Kim, Gyung Tae Chung, You-Jin Kim, Dokeun Kim, Jung-Ah Lee

Journal: Virology

PubMed ID: 35751974

Doi: 10.1016/j.virol.2022.06.006

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Structures and mechanism of the plant PIN-FORMED auxin transporter

Authors: Kien Lam Ung, Mikael Winkler, Lukas Schulz, Martina Kolb, Dorina P Janacek, Emil Dedic, David L Stokes, Ulrich Z Hammes, Bjørn Panyella Pedersen

Journal: Nature

PubMed ID: 35768502

Doi: 10.1038/s41586-022-04883-y

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Rapid titration of recombinant baculoviruses based on NanoLuc secretion in early infection

Authors: Jige Li, Meng Xu, Juan Sun, Junjun Li, Jianqing Chen, Qin Chen, Jian Chen

Journal: J Virol Methods

PubMed ID: 35728698

Doi: 10.1016/j.jviromet.2022.114565

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Anti-spike protein antibody responses to BNT162b2 mRNA vaccine: A single-center survey in a COVID-19 non-epidemic area in Japan

Authors: Sho Mokuda, Namiki Kawanishi, Shintaro Kuroshima, Junko Kono, Hirofumi Nakayama, Hiroshi Mieno, Masashi Kawamoto

Journal: Vaccine X

PubMed ID: 35692460

Doi: 10.1016/j.jvacx.2022.100173

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Tip60 acetylation of histone H3K4 temporally controls chromosome passenger complex localization

Authors: Ewa Niedzialkowska, Limin Liu, Cem Kuscu, Zachary Mayo, Wladek Minor, Brian D Strahl, Mazhar Adli, P Todd Stukenberg

Journal: Mol Biol Cell

PubMed ID: 35653296

Doi: 10.1091/mbc.E21-06-0283

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Construction and Characterization of T7 Bacteriophages Harboring Apidaecin-Derived Sequences

Authors: Tobias Ludwig, Ralf Hoffmann, Andor Krizsan

Journal: Curr Issues Mol Biol

PubMed ID: 35735615

Doi: 10.3390/cimb44060174

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Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents

Authors: Jaime S Rosa Duque, Xiwei Wang, Daniel Leung, Samuel M S Cheng, Carolyn A Cohen, Xiaofeng Mu, Asmaa Hachim, Yanmei Zhang, Sau Man Chan, Sara Chaothai, Kelvin K H Kwan, Karl C K Chan, John K C Li, Leo L H Luk, Leo C H Tsang, Wilfred H S Wong, Cheuk Hei Cheang, Timothy K Hung, Jennifer H Y Lam, Gilbert T Chua, Winnie W Y Tso, Patrick Ip, Masashi Mori, Niloufar Kavian, Wing Hang Leung, Sophie Valkenburg, Malik Peiris, Wenwei Tu, Yu Lung Lau

Journal: Nat Commun

PubMed ID: 35764637

Doi: 10.1038/s41467-022-31485-z

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PD-1 and ICOS coexpression identifies tumor-reactive CD4+ T cells in human solid tumors

Authors: Rebekka Duhen, Olivier Fesneau, Kimberly A Samson, Alexandra K Frye, Michael Beymer, Venkatesh Rajamanickam, David Ross, Eric Tran, Brady Bernard, Andrew D Weinberg, Thomas Duhen

Journal: J Clin Invest

PubMed ID: 35439168

Doi: 10.1172/JCI156821

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The DUX4 protein is a co-repressor of the progesterone and glucocorticoid nuclear receptors

Authors: Julieta Quintero, Nizar Y Saad, Sabrina M Pagnoni, Daniela K Jacquelin, Laura V Gatica, Scott Q Harper, Alberto L Rosa

Journal: FEBS Lett

PubMed ID: 35662006

Doi: 10.1002/1873-3468.14416

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HA and M2 sequences alter the replication of 2013-16 H1 live attenuated influenza vaccine infection in human nasal epithelial cell cultures

Authors: Laura M Canaday, Jessica D Resnick, Hsuan Liu, Harrison Powell, Alyssa M McCoy, Dat Nguyen, Andrew Pekosz

Journal: Vaccine

PubMed ID: 35718589

Doi: 10.1016/j.vaccine.2022.05.088

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Kinetics of immune responses to SARS-CoV-2 proteins in individuals with varying severity of infection and following a single dose of the AZD1222

Authors: Deshni Jayathilaka, Chandima Jeewandara, Laksiri Gomes, Tibutius Thanesh Pramanayagam Jayadas, Achala Kamaladasa, Gayasha Somathilake, Dinuka Guruge, Pradeep Darshana Pushpakumara, Thushali Ranasinghe, Inoka Sepali Aberathna, Saubhagya Danasekara, Buddini Gunathilaka, Heshan Kuruppu, Ananda Wijewickrama, Ruwan Wijayamuni, Lisa Schimanski, T K Tan, Graham S Ogg, Alain Townsend, Gathsaurie Neelika Malavige

Journal: Clin Exp Immunol

PubMed ID: 35641142

Doi: 10.1093/cei/uxac009

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De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts

Authors: Yameng Xu, Xinglong Wang, Chenyang Zhang, Xuan Zhou, Xianhao Xu, Luyao Han, Xueqin Lv, Yanfeng Liu, Song Liu, Jianghua Li, Guocheng Du, Jian Chen, Rodrigo Ledesma-Amaro, Long Liu

Journal: Nat Commun

PubMed ID: 35650215

Doi: 10.1038/s41467-022-30826-2

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ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

Authors: William Hancock-Cerutti, Zheng Wu, Peng Xu, Narayana Yadavalli, Marianna Leonzino, Arun Kumar Tharkeshwar, Shawn M Ferguson, Gerald S Shadel, Pietro De Camilli

Journal: J Cell Biol

PubMed ID: 35657605

Doi: 10.1083/jcb.202106046

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Biosynthetic potential of the global ocean microbiome

Authors: Lucas Paoli, Hans-Joachim Ruscheweyh, Clarissa C Forneris, Florian Hubrich, Satria Kautsar, Agneya Bhushan, Alessandro Lotti, Quentin Clayssen, Guillem Salazar, Alessio Milanese, Charlotte I Carlström, Chrysa Papadopoulou, Daniel Gehrig, Mikhail Karasikov, Harun Mustafa, Martin Larralde, Laura M Carroll, Pablo Sánchez, Ahmed A Zayed, Dylan R Cronin, Silvia G Acinas, Peer Bork, Chris Bowler, Tom O Delmont, Josep M Gasol, Alvar D Gossert, André Kahles, Matthew B Sullivan, Patrick Wincker, Georg Zeller, Serina L Robinson, Jörn Piel, Shinichi Sunagawa

Journal: Nature

PubMed ID: 35732736

Doi: 10.1038/s41586-022-04862-3

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Detection of the SARS-CoV-2 D614G Mutation Using VirSNiP SARS-CoV-2 Spike D614G Assay

Authors: Chih-Chieh Chen, Tze-Kiong Er

Journal: Clin Lab

PubMed ID: 35704738

Doi: 10.7754/Clin.Lab.2021.211009

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Expression optimization, purification, and biophysical characterization of a GluN2D-containing NMDA receptor

Authors: Aram Chang, Justin M Liu, Katrina Nguyen, P Rajesh Kumar

Journal: Protein Expr Purif

PubMed ID: 35752385

Doi: 10.1016/j.pep.2022.106129

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Targeting the interaction of GABA receptors with CaMKII with an interfering peptide restores receptor expression after cerebral ischemia and inhibits progressive neuronal death in mouse brain cells and slices

Authors: Karthik Balakrishnan, Mohammad Hleihil, Musadiq A Bhat, Robert P Ganley, Markus Vaas, Jan Klohs, Hanns Ulrich Zeilhofer, Dietmar Benke

Journal: Brain Pathol

PubMed ID: 35698024

Doi: 10.1111/bpa.13099

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Comparison of the Immunogenic Properties of Carrying the Mycobacterial Ag85B-ESAT-6 Antigen at Various Cellular Localizations

Authors: Kamilla Wiull, Preben Boysen, Katarzyna Kuczkowska, Lars Fredrik Moen, Harald Carlsen, Vincent G H Eijsink, Geir Mathiesen

Journal: Front Microbiol

PubMed ID: 35722346

Doi: 10.3389/fmicb.2022.900922

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MRCKα is a novel regulator of prolactin-induced lactogenesis in bovine mammary epithelial cells

Authors: Fang Wang, Jürgen van Baal, Lu Ma, Xuejun Gao, Jan Dijkstra, Dengpan Bu

Journal: Anim Nutr

PubMed ID: 35891685

Doi: 10.1016/j.aninu.2022.06.001

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Identification and Characterization of an RRM-Containing, RNA Binding Protein in

Authors: Caterina Ciani, Anna Pérez-Ràfols, Isabelle Bonomo, Mariachiara Micaelli, Alfonso Esposito, Chiara Zucal, Romina Belli, Vito Giuseppe D'Agostino, Irene Bianconi, Vito Calderone, Linda Cerofolini, Orietta Massidda, Michael Bernard Whalen, Marco Fragai, Alessandro Provenzani

Journal: Biomolecules

PubMed ID: 35883478

Doi: 10.3390/biom12070922

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Development and Evaluation of Rapid and Accurate CRISPR/Cas13-Based RNA Diagnostics for Pneumonia

Authors: Yangqing Zhan, Xiaoqing Gao, Shaoqiang Li, Yeqi Si, Yuanxiang Li, Xu Han, Wenjun Sun, Zhengtu Li, Feng Ye

Journal: Front Cell Infect Microbiol

PubMed ID: 35782118

Doi: 10.3389/fcimb.2022.904485

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Inactivated whole-virion vaccine BBV152/Covaxin elicits robust cellular immune memory to SARS-CoV-2 and variants of concern

Authors: Rajesh Vikkurthi, Asgar Ansari, Anupama R Pai, Someshwar Nath Jha, Shilpa Sachan, Suvechchha Pandit, Bhushan Nikam, Anurag Kalia, Bimal Prasad Jit, Hilal Ahmad Parray, Savita Singh, Pallavi Kshetrapal, Nitya Wadhwa, Tripti Shrivastava, Poonam Coshic, Suresh Kumar, Pragya Sharma, Nandini Sharma, Juhi Taneja, Anil K Pandey, Ashok Sharma, Ramachandran Thiruvengadam, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Shinjini Bhatnagar, Nimesh Gupta

Journal: Nat Microbiol

PubMed ID: 35681012

Doi: 10.1038/s41564-022-01161-5

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Increasing the resilience of plant immunity to a warming climate

Authors: Jong Hum Kim, Christian Danve M Castroverde, Shuai Huang, Chao Li, Richard Hilleary, Adam Seroka, Reza Sohrabi, Diana Medina-Yerena, Bethany Huot, Jie Wang, Kinya Nomura, Sharon K Marr, Mary C Wildermuth, Tao Chen, John D MacMicking, Sheng Yang He

Journal: Nature

PubMed ID: 35768511

Doi: 10.1038/s41586-022-04902-y

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Codon Optimization Using a Recurrent Neural Network

Authors: Dennis R Goulet, Yongqi Yan, Palak Agrawal, Andrew B Waight, Amanda Nga-Sze Mak, Yi Zhu

Journal: J Comput Biol

PubMed ID: 35727687

Doi: 10.1089/cmb.2021.0458

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Screening membraneless organelle participants with machine-learning models that integrate multimodal features

Authors: Zhaoming Chen, Chao Hou, Liang Wang, Chunyu Yu, Taoyu Chen, Boyan Shen, Yaoyao Hou, Pilong Li, Tingting Li

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35687670

Doi: 10.1073/pnas.2115369119

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Characterization, expression and function of the pyrokinins (PKs) in the giant freshwater prawn, Macrobrachium rosenbergii

Authors: Tipsuda Thongbuakaew, Sirirak Mukem, Arada Chaiyamoon, Kanjana Khornchatri, Thanapong Kruangkum, Scott F Cummins, Prasert Sobhon

Journal: J Exp Biol

PubMed ID: 35578905

Doi: 10.1242/jeb.243742

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Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition

Authors: Eric T Baldwin, Matthias Götte, Egor P Tchesnokov, Eddy Arnold, Margit Hagel, Charles Nichols, Pam Dossang, Marieke Lamers, Paul Wan, Stefan Steinbacher, Donna L Romero

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35771941

Doi: 10.1073/pnas.2200260119

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TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules

Authors: Andrew C McShan, Christine A Devlin, Georgia F Papadaki, Yi Sun, Adam I Green, Giora I Morozov, George M Burslem, Erik Procko, Nikolaos G Sgourakis

Journal: Nat Chem Biol

PubMed ID: 35725941

Doi: 10.1038/s41589-022-01049-9

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A Nanopore-Based Saccharide Sensor

Authors: Shanyu Zhang, Zhenyuan Cao, Pingping Fan, Yuqin Wang, Wendong Jia, Liying Wang, Kefan Wang, Yao Liu, Xiaoyu Du, Chengzhen Hu, Panke Zhang, Hong-Yuan Chen, Shuo Huang

Journal: Angew Chem Int Ed Engl

PubMed ID: 35718742

Doi: 10.1002/anie.202203769

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Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis

Authors: Dezheng Zhou, Zhenshu Li, Yue Sun, Jing Yan, Guowei Huang and Wen Li

Journal: Int. J. Mol. Sci

Doi: doi.org/10.3390/ijms23136948

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Thymosin β4 increases cardiac cell proliferation, cell engraftment, and the reparative potency of human induced-pluripotent stem cell-derived cardiomyocytes in a porcine model of acute myocardial infarction

Authors: Shi Hua Tan , Sze Jie Loo , Yu Gao , Zhong Hao Tao , Li Ping Su , Chen Xu Wang , Sophia L Zhang , Yong Hui Mu , Ying Hua Cui , Desiree Abdurrachim , Wei Hsin Wang , Janise Lalic , Kheng Choon Lim , Jun Bu , Ru San Tan , Teck Hock Lee , Jianyi Zhang , Lei Ye

Journal: Theranostics

PubMed ID: 34335970

Doi: 10.7150/thno.56757

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Missense mutations affecting Ca-coordination in GCAP1 lead to cone-rod dystrophies by altering protein structural and functional properties

Authors: Giuditta Dal Cortivo, Valerio Marino, Francesco Bonì, Mario Milani, Daniele Dell'Orco

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 32650103

Doi: 10.1016/j.bbamcr.2020.118794

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A proof-of-concept study on the use of a fluorescein-based 18F-tracer for pretargeted PET

Authors: Hugo Helbert , Emily M Ploeg , Douwe F Samplonius , Simon N Blok , Ines F Antunes , Verena I Böhmer , Gert Luurtsema , Rudi A J O Dierckx , Ben L Feringa , Philip H Elsinga , Wiktor Szymanski , Wijnand Helfrich

Journal: EJNMMI Radiopharm Chem .

PubMed ID: 35239034

Doi: 10.1186/s41181-022-00155-2

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Lentiviral gene therapy prevents anti-human acid α-glucosidase antibody formation in murine Pompe disease

Authors: Qiushi Liang, Eva C Vlaar, Fabio Catalano, Joon M Pijnenburg, Merel Stok, Yvette van Helsdingen, Arnold G Vulto, Wendy W J Unger, Ans T van der Ploeg, W W M Pim Pijnappel, Niek P van Til

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35662813

Doi: 10.1016/j.omtm.2022.04.016

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Biosynthesis of valerenic acid by engineered Saccharomyces cerevisiae

Authors: Mengya Zhao, Chuanbo Zhang, Haibin Wang, Shifan He, Wenyu Lu

Journal: Biotechnol Lett

PubMed ID: 35643816

Doi: 10.1007/s10529-022-03264-9

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Humoral Immune Response Diversity to Different COVID-19 Vaccines: Implications for the "Green Pass" Policy

Authors: Immacolata Polvere, Alfredina Parrella, Lucrezia Zerillo, Serena Voccola, Gaetano Cardinale, Silvia D'Andrea, Jessica Raffaella Madera, Romania Stilo, Pasquale Vito, Tiziana Zotti

Journal: Front Immunol

PubMed ID: 35634315

Doi: 10.3389/fimmu.2022.833085

Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer

Authors: Tingjia Zhu, Yixuan Cen, Zhuoye Chen, Yanan Zhang, Lu Zhao, Jiaying Wang, Weiguo Lu, Xing Xie, Xinyu Wang

Journal: Cell Death Dis

PubMed ID: 35595754

Doi: 10.1038/s41419-022-04943-1

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Epitope-Based Vaccines against the Major Outer Membrane Protein Variable Domain 4 Elicit Protection in Mice

Authors: Amanda L Collar, Alexandria C Linville, Susan B Core, Kathryn M Frietze

Journal: Vaccines (Basel)

PubMed ID: 35746483

Doi: 10.3390/vaccines10060875

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Covalent Adduct Formation in Methylthio-d-ribose-1-phosphate Isomerase: Reaction Intermediate or Artifact?

Authors: Vamsee M Veeramachineni, Subashi T Ubayawardhana, Andrew S Murkin

Journal: Biochemistry

PubMed ID: 35580612

Doi: 10.1021/acs.biochem.2c00142

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CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids

Authors: Megan Lo, Amnon Sharir, Michael D Paul, Hayarpi Torosyan, Christopher Agnew, Amy Li, Cynthia Neben, Pauline Marangoni, Libin Xu, David R Raleigh, Natalia Jura, Ophir D Klein

Journal: Nat Commun

PubMed ID: 35504891

Doi: 10.1038/s41467-022-30186-x

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Coronavirus Disease 2019 Vaccine Booster Effects Are Seen in Human Milk Antibody Response

Authors: Jeffrey M Bender, Yesun Lee, Wesley A Cheng, Carolyn J Marentes Ruiz, Pia S Pannaraj

Journal: Front Nutr

PubMed ID: 35685893

Doi: 10.3389/fnut.2022.898849

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Enhancing fluxes through the mevalonate pathway in Saccharomyces cerevisiae by engineering the HMGR and β-alanine metabolism

Authors: Surui Lu, Chenyao Zhou, Xuena Guo, Zhengda Du, Yanfei Cheng, Zhaoyue Wang, Xiuping He

Journal: Microb Biotechnol

PubMed ID: 35531990

Doi: 10.1111/1751-7915.14072

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The key sulfometuron-methyl degrading bacteria isolation based on soil bacterial phylogenetic molecular ecological networks and application for bioremediation of contaminated soil by immobilization

Authors: Hao Zhang, Chun-Yang Liu, Xin Zhang, Hui-Ying Yang, Jie Sun, Cheng-Bin Liu, Na Li

Journal: Ecotoxicol Environ Saf

PubMed ID: 35561546

Doi: 10.1016/j.ecoenv.2022.113605

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Smartly responsive DNA-miRNA hybrids packaged in exosomes for synergistic enhancement of cancer cell apoptosis

Authors: Fan Zhang, Albertina N Isak, Shiqi Yang, Yuchen Song, Lingjie Ren, Chang Feng, Guifang Chen

Journal: Nanoscale

PubMed ID: 35421879

Doi: 10.1039/d1nr08539e

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Identification of RBMX as a splicing regulator in Parkinsonian mimetic induced alternative splicing of α-synuclein

Authors: Swaroop Thonda, Ravali L Vinnakota, Swathi V Kona, Shasi V Kalivendi

Journal: Biochim Biophys Acta Gene Regul Mech

PubMed ID: 35577270

Doi: 10.1016/j.bbagrm.2022.194825

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Glutathione S-transferase: a candidate gene for berry color in muscadine grapes (Vitis rotundifolia)

Authors: Aruna Varanasi, Margaret Worthington, Lacy Nelson, Autumn Brown, Thomas Mason Chizk, Renee Threlfall, Luke Howard, Patrick Conner, Rosa Figueroa-Balderas, Mélanie Massonnet, Dario Cantu, John R Clark

Journal: G3 (Bethesda)

PubMed ID: 35302606

Doi: 10.1093/g3journal/jkac060

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Crosstalk between IL-15Rα tumor-associated macrophages and breast cancer cells reduces CD8 T cell recruitment

Authors: Wenlong Zhang, Qing Zhang, Nanfei Yang, Qian Shi, Huifang Su, Tingsheng Lin, Zhonglei He, Wenxin Wang, Hongqian Guo, Pingping Shen

Journal: Cancer Commun (Lond)

PubMed ID: 35615815

Doi: 10.1002/cac2.12311

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Self-Assembling Nanovaccine Confers Complete Protection Against Zika Virus Without Causing Antibody-Dependent Enhancement

Authors: Heng Rong, Mi Qi, Jingdi Pan, Yuhan Sun, Jiawang Gao, Xiaowei Zhang, Wei Li, Bo Zhang, Xian-En Zhang, Zongqiang Cui

Journal: Front Immunol

PubMed ID: 35615356

Doi: 10.3389/fimmu.2022.905431

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A Novel Ig Domain-Containing C-Type Lectin Triggers the Intestine-Hemocyte Axis to Regulate Antibacterial Immunity in Crab

Authors: Kaimin Zhou, Yukai Qin, Yu Song, Ke Zhao, Weijuan Pan, Xingyu Nan, Yue Wang, Qun Wang, Weiwei Li

Journal: J Immunol

PubMed ID: 35508356

Doi: 10.4049/jimmunol.2101027

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Structural basis of sodium-dependent bile salt uptake into the liver

Authors: Kapil Goutam, Francesco S Ielasi, Els Pardon, Jan Steyaert, Nicolas Reyes

Journal: Nature

PubMed ID: 35545671

Doi: 10.1038/s41586-022-04723-z

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Duo Cadherin-Functionalized Microparticles Synergistically Induce Chondrogenesis and Cartilage Repair of Stem Cell Aggregates

Authors: Xueping Wang, Xingquan Xu, Yan Zhang, Xueying An, Xue Zhang, Guoqiang Chen, Qing Jiang, Jun Yang

Journal: Adv Healthc Mater

PubMed ID: 35485302

Doi: 10.1002/adhm.202200246

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Revisiting misfolding propensity of serum amyloid A1: Special focus on the signal peptide region

Authors: Morgan S Haines, Eduardo Ramirez, Kendall B E Moore, Jessica S Fortin

Journal: Biochem Biophys Rep

PubMed ID: 35664543

Doi: 10.1016/j.bbrep.2022.101284

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Antibodies targeting the European lobster (Palinurus elephas) vitellogenin developed by mRNA isolation and in-silico-designed antigenic peptides

Authors: Faustina B Cannea, Maria Cristina Follesa, Cristina Porcu, Rossano Rossino, Alessandra Olianas, Antonio Rescigno, Alessandra Padiglia

Journal: Biol Open

PubMed ID: 35452506

Doi: 10.1242/bio.059019

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Small, charged proteins in salmon louse (Lepeophtheirus salmonis) secretions modulate Atlantic salmon (Salmo salar) immune responses and coagulation

Authors: Aina-Cathrine Øvergård, Helena M D Midtbø, Lars A Hamre, Michael Dondrup, Gro E K Bjerga, Øivind Larsen, Jiwan Kumar Chettri, Kurt Buchmann, Frank Nilsen, Sindre Grotmol

Journal: Sci Rep

PubMed ID: 35568726

Doi: 10.1038/s41598-022-11773-w

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Functional validation of a novel AAAS variant in an atypical presentation of Allgrove syndrome

Authors: Erica L Macke, Joel A Morales-Rosado, Sarah K Macklin-Mantia, Christopher T Schmitz, Björn Oskarsson, Eric W Klee, Klaas J Wierenga

Journal: Mol Genet Genomic Med

PubMed ID: 35570467

Doi: 10.1002/mgg3.1966

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SARS-CoV-2 BA1 variant is neutralized by vaccine booster-elicited serum but evades most convalescent serum and therapeutic antibodies

Authors: Sabrina Lusvarghi, Simon D Pollett, Sabari Nath Neerukonda, Wei Wang, Richard Wang, Russell Vassell, Nusrat J Epsi, Anthony C Fries, Brian K Agan, David A Lindholm, Christopher J Colombo, Rupal Mody, Evan C Ewers, Tahaniyat Lalani, Anuradha Ganesan, Emilie Goguet, Monique Hollis-Perry, Si'Ana A Coggins, Mark P Simons, Leah C Katzelnick, Gregory Wang, David R Tribble, Lisa Bentley, Ann E Eakin, Christopher C Broder, Karl J Erlandson, Eric D Laing, Timothy H Burgess, Edward Mitre, Carol D Weiss

Journal: Sci Transl Med

PubMed ID: 35380448

Doi: 10.1126/scitranslmed.abn8543

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Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast

Authors: Tengfei Liu , Yuanwei Gou , Bei Zhang , Rui Gao , Chang Dong , Mingming Qi , Lihong Jiang , Xuanwei Ding , Chun Li , Jiazhang Lian

Journal: Biotechnol Bioeng

PubMed ID: 35060115

Doi: doi.org/10.1002/bit.28040

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Using large-scale multi-module NRPS to heterologously prepare highly efficient lipopeptide biosurfactants in recombinant Escherichia coli

Authors: Ting Zhang , Qiang Zhou

Journal: Enzyme Microb Technol

PubMed ID: 35660853

Doi: doi.org/10.1016/j.enzmictec.2022.110068

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Gold Glyconanoparticles Combined with 91-99 Peptide of the Bacterial Toxin, Listeriolysin O, Are Efficient Immunotherapies in Experimental Bladder Tumors

Authors: Hector Terán-Navarro, Andrea Zeoli, David Salines-Cuevas, Marco Marradi, Noemi Montoya, Elena Gonzalez-Lopez, Javier Gonzalo Ocejo-Vinyals, Mario Dominguez-Esteban, Jose Luis Gutierrez-Baños, Felix Campos-Juanatey, Sonsoles Yañez-Diaz, Almudena Garcia-Castaño, Fernando Rivera, Ignacio Duran, Carmen Alvarez-Dominguez

Journal: Cancers (Basel)

PubMed ID: 35626016

Doi: 10.3390/cancers14102413

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AntiV-SGN: a universal antiviral strategy to combat both RNA and DNA viruses by destroying their nucleic acids without sequence limitation

Authors: Kun Tian, Zhen Qi, Ying Chi, Huanran Qiang, Pei Wang, Yu Liu, Guohua Zhou, Fengcai Zhu, Qinglong Guo, Shu Xu

Journal: Microb Biotechnol

PubMed ID: 35611874

Doi: 10.1111/1751-7915.14076

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A Novel Small RNA, DsrO, in Deinococcus radiodurans Promotes Methionine Sulfoxide Reductase () Expression for Oxidative Stress Adaptation

Authors: Yun Chen, Mingming Zhao, Mengli Lv, Min Lin, Jin Wang, Kaijing Zuo

Journal: Appl Environ Microbiol

PubMed ID: 35575549

Doi: 10.1128/aem.00038-22

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Selenium in Proteins: Conformational Changes Induced by Se Substitution on Methionine, as Studied in Isolated Model Peptides by Optical Spectroscopy and Quantum Chemistry

Authors: Gildas Goldsztejn, Venkateswara Rao Mundlapati, Valérie Brenner, Eric Gloaguen, Michel Mons

Journal: Molecules

PubMed ID: 35630640

Doi: 10.3390/molecules27103163

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Lactoferrin Inhibition of the Complex Formation between ACE2 Receptor and SARS CoV-2 Recognition Binding Domain

Authors: Roberta Piacentini, Laura Centi, Mattia Miotto, Edoardo Milanetti, Lorenzo Di Rienzo, Martina Pitea, Paolo Piazza, Giancarlo Ruocco, Alberto Boffi, Giacomo Parisi

Journal: Int J Mol Sci

PubMed ID: 35628247

Doi: 10.3390/ijms23105436

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α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins

Authors: Weidong Jing, Jordan Lo Pilato, Callum Kay, Shouya Feng, Daniel Enosi Tuipulotu, Anukriti Mathur, Cheng Shen, Chinh Ngo, Anyang Zhao, Lisa A Miosge, Sidra A Ali, Elizabeth E Gardiner, Milena M Awad, Dena Lyras, Avril A B Robertson, Nadeem O Kaakoush, Si Ming Man

Journal: Sci Immunol

PubMed ID: 35594341

Doi: 10.1126/sciimmunol.abm1803

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Computational approach for binding prediction of SARS-CoV-2 with neutralizing antibodies

Authors: Daria Beshnova, Yan Fang, Mingjian Du, Yehui Sun, Fenghe Du, Jianfeng Ye, Zhijian James Chen, Bo Li

Journal: Comput Struct Biotechnol J

PubMed ID: 35530743

Doi: 10.1016/j.csbj.2022.04.038

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An Immunoinformatic Strategy to Develop New Multi-epitope Vaccine

Authors:

Journal: INT J PEPT RES THER

PubMed ID: 35573911

Doi: 10.1007/s10989-022-10406-0

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