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Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling

Authors: Kim van Kuijk, Jasper A F Demandt, Javier Perales-Patón, Thomas L Theelen, Christoph Kuppe, Elke Marsch, Jenny de Bruijn, Han Jin, Marion J Gijbels, Ljubica Matic, Barend M E Mees, Chris P M Reutelingsperger, Ulf Hedin, Erik A L Biessen, Peter Carmeliet, Andrew H Baker, Rafael K Kramann, Leon J Schurgers, Julio Saez-Rodriguez, Judith C Sluimer

Journal: Cardiovasc Res

PubMed ID: 33913468

Doi: 10.1093/cvr/cvab152

Products & Services: Proteins, Expression, Isolation and Analysis

Therapeutic Effect of Melittin-dKLA Targeting Tumor-Associated Macrophages in Melanoma

Authors: Ik-Hwan Han, Chanmi Jeong, Juwon Yang, Seung-Hyeok Park, Deok-Sang Hwang, Hyunsu Bae

Journal: Int J Mol Sci

PubMed ID: 35328518

Doi: 10.3390/ijms23063094

Products & Services: Biochemicals

Injectable Slow-Release Hydrogel Formulation of a Plant Virus-Based COVID-19 Vaccine Candidate

Authors: Christian Isalomboto Nkanga, Oscar A Ortega-Rivera, Matthew D Shin, Miguel A Moreno-Gonzalez, Nicole F Steinmetz

Journal: Biomacromolecules

PubMed ID: 35344365

Doi: 10.1021/acs.biomac.2c00112

Products & Services: Recombinant Proteins

Evaluation of the Humoral Immune Response of a Heterologous Vaccination between BBIBP-CorV and BNT162b2 with a Temporal Separation of 7 Months, in Peruvian Healthcare Workers with and without a History of SARS-CoV-2 Infection

Authors: Miguel Hueda-Zavaleta, Juan C Gómez de la Torre, José Alonso Cáceres-Del Aguila, Cecilia Muro-Rojo, Nathalia De La Cruz-Escurra, Daniella Arenas Siles, Diana Minchón-Vizconde, Cesar Copaja-Corzo, Fabrizzio Bardales-Silva, Vicente A Benites-Zapata, Alfonso J Rodriguez-Morales

Journal: Vaccines (Basel)

PubMed ID: 35455251

Doi: 10.3390/vaccines10040502

Phage Therapy Potentiates Second-Line Antibiotic Treatment against Pneumonic Plague

Authors: Yaron Vagima, David Gur, Moshe Aftalion, Sarit Moses, Yinon Levy, Arik Makovitzki, Tzvi Holtzman, Ziv Oren, Yaniv Segula, Ella Fatelevich, Avital Tidhar, Ayelet Zauberman, Shahar Rotem, Emanuelle Mamroud, Ida Steinberger-Levy

Journal: Viruses

PubMed ID: 35458417

Doi: 10.3390/v14040688

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Structure-based design and construction of a synthetic phage display nanobody library

Authors: Ernesto Moreno, Mario S Valdés-Tresanco, Andrea Molina-Zapata, Oliberto Sánchez-Ramos

Journal: BMC Res Notes

PubMed ID: 35351202

Doi: 10.1186/s13104-022-06001-7

Products & Services: Gene Synthesis

Highly Specific Monoclonal Antibody Targeting the Botulinum Neurotoxin Type E Exposed SNAP-25 Neoepitope

Authors: Adva Mechaly, Eran Diamant, Ron Alcalay, Alon Ben David, Eyal Dor, Amram Torgeman, Ada Barnea, Meni Girshengorn, Lilach Levin, Eyal Epstein, Ariel Tennenhouse, Sarel J Fleishman, Ran Zichel, Ohad Mazor

Journal: Antibodies (Basel)

PubMed ID: 35323195

Doi: 10.3390/antib11010021

Products & Services: Peptide Synthesis

COVID-19 Breakthrough Infection after Inactivated Vaccine Induced Robust Antibody Responses and Cross-Neutralization of SARS-CoV-2 Variants, but Less Immunity against Omicron

Authors: Nungruthai Suntronwong, Ritthideach Yorsaeng, Jiratchaya Puenpa, Chompoonut Auphimai, Thanunrat Thongmee, Preeyaporn Vichaiwattana, Sitthichai Kanokudom, Thaneeya Duangchinda, Warangkana Chantima, Pattarakul Pakchotanon, Suvichada Assawakosri, Pornjarim Nilyanimit, Sirapa Klinfueng, Lakkhana Wongsrisang, Donchida Srimuan, Thaksaporn Thatsanatorn, Natthinee Sudhinaraset, Nasamon Wanlapakorn, Yong Poovorawan

Journal: Vaccines (Basel)

PubMed ID: 35335023

Doi: 10.3390/vaccines10030391

Selection and Application of ssDNA Aptamers for Fluorescence Biosensing Detection of Malachite Green

Authors: Miaojia Xie, Zanlin Chen, Fengguang Zhao, Ying Lin, Suiping Zheng, Shuangyan Han

Journal: Foods

PubMed ID: 35327224

Doi: 10.3390/foods11060801

Products & Services: Gene Synthesis

Evaluation of a commercial ELISA as alternative to plaque reduction neutralization test to detect neutralizing antibodies against SARS-CoV-2

Authors: Natalie Hofmann, Marica Grossegesse, Markus Neumann, Lars Schaade, Andreas Nitsche

Journal: Sci Rep

PubMed ID: 35241780

Doi: 10.1038/s41598-022-07597-3

Products & Services: Recombinant Proteins

Leptin secreted from testicular microenvironment modulates hedgehog signaling to augment the endogenous function of Leydig cells

Authors: Himanshu Arora, Rehana Qureshi, Kajal Khodamoradi, Deepa Seetharam, Madhumita Parmar, Derek J Van Booven, Isabelle Catherine Issa, Robert Sackstein, Dolores Lamb, Joshua M Hare, Ranjith Ramasamy

Journal: Cell Death Dis

PubMed ID: 35246515

Doi: 10.1038/s41419-022-04658-3

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Neutralizing antibody responses 300 days after SARS-CoV-2 infection and induction of high antibody titers after vaccination

Authors: Doris Urlaub, Natalie Wolfsdorff, Jan-Erik Hoffmann, Stefanie Dorok, Markus Hoffmann, Moritz Anft, Naomi Pieris, Patrick Günther, Bernhard Schaaf, Uwe Cassens, Peter Bröde, Maren Claus, Lea K Picard, Sabine Wingert, Simone Backes, Deniz Durak, Nina Babel, Stefan Pöhlmann, Frank Renken, Stefan Raunser, Carsten Watzl

Journal: Eur J Immunol

PubMed ID: 35247269

Doi: 10.1002/eji.202149758

Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a

Authors: Shuhan Lu, Xiaohan Tong, Yang Han, Kun Zhang, Yizhou Zhang, Qiubing Chen, Junyi Duan, Xinlin Lei, Muhan Huang, Yang Qiu, Ding-Yu Zhang, Xi Zhou, Ying Zhang, Hao Yin

Journal: Nat Biomed Eng

PubMed ID: 35314803

Doi: 10.1038/s41551-022-00861-x

Products & Services: Gene Synthesis

A novel Lgi1 mutation causes white matter abnormalities and impairs motor coordination in mice

Authors: Xiao-Yu Teng , Ping Hu , Yangyang Chen , Yanyu Zang , Xiaolian Ye, Jingmin Ou , Guiquan Chen , Yun Stone Shi

Journal: FASEB J

PubMed ID: 35167164

Doi: 10.1096/fj.202101652R

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Impact of Modular Architecture on Activity of Glycoside Hydrolase Family 5 Subfamily 8 Mannanases

Authors: Marie Sofie Møller

Journal: Molecules

PubMed ID: 35335278

Doi: 10.3390/molecules27061915

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Non-binary Encoded Nucleic Acid Barcodes Directly Readable by a Nanopore

Authors: Shuanghong Yan , Liying Wang , Yuqin Wang , Zhenyuan Cao , Shanyu Zhang , Xiaoyu Du , Pingping Fan , Panke Zhang , Hong-Yuan Chen , Shuo Huang

Journal: Angew Chem Int Ed Engl

PubMed ID: 35261129

Doi: 10.1002/anie.202116482

Products & Services: Plasmid DNA Preparation

Comparative genomics reveal the convergent evolution of CYP82D and CYP706X members related to flavone biosynthesis in Lamiaceae and Asteraceae

Authors: Ranran Gao, Qian Lou, Lijun Hao, Guihong Qi, Ya Tian, Xiangdong Pu, Chunnian He, Yu Wang, Wenjie Xu, Zhichao Xu, Jingyuan Song

Journal: Plant J

PubMed ID: 34907610

Doi: 10.1111/tpj.15634

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Unusual (2R,6R)-bicyclo[3.1.1]heptane ring construction in fungal a-trans-bergamotene biosynthesis

Authors: Yan-Hua Wen , Tian-Jiao Chen , Long-Yu Jiang , Li Li , Mengbo Guo , Yu Peng , Jing-Jing Chen , Fei Pei , Jin-Ling Yang , Rui-Shan Wang , Ting Gong , Ping Zhu

Journal: iScience

PubMed ID: 35345459

Doi: 10.1016/j.isci.2022.104030

Products & Services: Gene Synthesis

Structural Insight into KsBcl-2 Mediated Apoptosis Inhibition by Kaposi Sarcoma Associated Herpes Virus

Authors: Chathura D Suraweera , Mark G Hinds , Marc Kvansakul

Journal: Viruses

PubMed ID: 35458468

Doi: 10.3390/v14040738

Products & Services: Gene Synthesis

Lactobacillus murinus alleviate intestinal ischemia/reperfusion injury through promoting the release of interleukin-10 from M2 macrophages via Toll-like receptor 2 signaling

Authors: Jingjuan Hu, Fan Deng, Bingcheng Zhao, Zebin Lin, Qishun Sun, Xiao Yang, Mei Wu, Shida Qiu, Yu Chen, Zhengzheng Yan, Sidan Luo, Jin Zhao, Weifeng Liu, Cai Li, Ke Xuan Liu

Journal: Microbiome

PubMed ID: 35241180

Doi: 10.1186/s40168-022-01227-w

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular characterization, immunofluorescent localization, and expression levels of two bicarbonate anion transporters in the whitish mantle of the giant clam, Tridacna squamosa, and the implications for light-enhanced shell formation

Authors: Mel V Boo, Caryn Z Pang, Shit F Chew, Yuen K Ip

Journal: Comp Biochem Physiol A Mol Integr Physiol

PubMed ID: 35337976

Doi: 10.1016/j.cbpa.2022.111200

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Fine Mapping of the Region Identified rs7175517 as a Causal Variant Related to BMI in China and the United Kingdom Populations

Authors: Ce Lu, Hai-Jun Wang, Jie-Yun Song, Shuo Wang, Xue-Ying Li, Tao Huang, Hui Wang

Journal: Front Genet

PubMed ID: 35368675

Doi: 10.3389/fgene.2022.838685

Products & Services: Custom DNA/RNA Oligos

Dynamic observation of SARS-CoV-2 IgM, IgG, and neutralizing antibodies in the development of population immunity through COVID-19 vaccination

Authors: Ruiwei Jiang, Xiaowen Dou, Min Li, Enyun Wang, Jiwen Hu, Dan Xiong, Xiuming Zhang

Journal: J Clin Lab Anal

PubMed ID: 35235705

Doi: 10.1002/jcla.24325

Angiotensin (1-7) peptide replacement therapy with plasma transfusion in COVID-19

Authors: Hasan Onal, Nurcan Ucuncu Ergun, Bengu Arslan, Seyma Topuz, Seda Yilmaz Semerci, Osman Mutluhan Ugurel, Murat Topuzogullari, Ali Kalkan, Sengul Aydin Yoldemir, Nurettin Suner, Ali Kocatas

Journal: Transfus Apher Sci

PubMed ID: 35305923

Doi: 10.1016/j.transci.2022.103418

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Comparative Network Biology Discovers Protein Complexes That Underline Cellular Differentiation in Anabaena sp

Authors: Chen Xu, Bing Wang, Hailu Heng, Jiangmei Huang, Cuihong Wan

Journal: Mol Cell Proteomics

PubMed ID: 35288331

Doi: 10.1016/j.mcpro.2022.100224

Products & Services: Proteins, Expression, Isolation and Analysis

Nup98 Is Subverted from Annulate Lamellae by Hepatitis C Virus Core Protein to Foster Viral Assembly

Authors: Bertrand Boson, Chloé Mialon, Konstanze Schichl, Solène Denolly, François-Loïc Cosset

Journal: MBio

PubMed ID: 35258330

Doi: 10.1128/mbio.02923-21

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Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

Authors: Eva Mittler, Anna Z Wec, Janne Tynell, Pablo Guardado-Calvo, Julia Wigren-Byström, Laura C Polanco, Cecilia M O'Brien, Megan M Slough, Dafna M Abelson, Alexandra Serris, Mrunal Sakharkar, Gerard Pehau-Arnaudet, Russell R Bakken, James C Geoghegan, Rohit K Jangra, Markus Keller, Larry Zeitlin, Olli Vapalahti, Rainer G Ulrich, Zachary A Bornholdt, Clas Ahlm, Felix A Rey, John M Dye, Steven B Bradfute, Tomas Strandin, Andrew S Herbert, Mattias N E Forsell, Laura M Walker, Kartik Chandran

Journal: Sci Transl Med

PubMed ID: 35294259

Doi: 10.1126/scitranslmed.abl5399

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Structural and mechanistic basis for redox sensing by the cyanobacterial transcription regulator RexT

Authors: Bin Li, Minshik Jo, Jianxin Liu, Jiayi Tian, Robert Canfield, Jennifer Bridwell-Rabb

Journal: Commun Biol

PubMed ID: 35347217

Doi: 10.1038/s42003-022-03226-x

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HSV-2-Specific Human Female Reproductive Tract Tissue Resident Memory T Cells Recognize Diverse HSV Antigens

Authors: David M Koelle, Lichun Dong, Lichen Jing, Kerry J Laing, Jia Zhu, Lei Jin, Stacy Selke, Anna Wald, Dana Varon, Meei-Li Huang, Christine Johnston, Lawrence Corey, Christine M Posavad

Journal: Front Immunol

PubMed ID: 35432373

Doi: 10.3389/fimmu.2022.867962

Products & Services: ORF cDNA Clones/MolecularCloud

Accurate positioning of functional residues with robotics-inspired computational protein design

Authors: Cody Krivacic, Kale Kundert, Xingjie Pan, Roland A Pache, Lin Liu, Shane O Conchúir, Jeliazko R Jeliazkov, Jeffrey J Gray, Michael C Thompson, James S Fraser, Tanja Kortemme

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35254891

Doi: 10.1073/pnas.2115480119

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Robust, Durable Gene Activation In Vivo via mRNA-Encoded Activators

Authors: Jared P Beyersdorf, Swapnil Bawage, Nahid Iglesias, Hannah E Peck, Ryan A Hobbs, Jay A Wroe, Chiara Zurla, Charles A Gersbach, Philip J Santangelo

Journal: ACS Nano

PubMed ID: 35357116

Doi: 10.1021/acsnano.1c10631

Products & Services: Gene Synthesis

Magnetic field-assisted aligned patterning in an alginate-silk fibroin/nanocellulose composite for guided wound healing

Authors: Keya Ganguly, Hexiu Jin, Sayan Deb Dutta, Dinesh K Patel, Tejal V Patil, Ki-Taek Lim

Journal: Carbohydr Polym

PubMed ID: 35422287

Doi: 10.1016/j.carbpol.2022.119321

Products & Services: Mammalian Expression

Characterization of SARS-CoV-2 Variants B16171 (Kappa), B16172 (Delta), and B1618 by Cell Entry and Immune Evasion

Authors: Wenlin Ren, Xiaohui Ju, Mingli Gong, Jun Lan, Yanying Yu, Quanxin Long, Devin J Kenney, Aoife K O'Connell, Yu Zhang, Jin Zhong, Guocai Zhong, Florian Douam, Xinquan Wang, Ailong Huang, Rong Zhang, Qiang Ding

Journal: MBio

PubMed ID: 35266815

Doi: 10.1128/mbio.00099-22

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A Novel Anti-CD73 Antibody That Selectively Inhibits Membrane CD73 Shows Antitumor Activity and Induces Tumor Immune Escape

Authors: Markus Kellner, Bettina von Neubeck, Bastian Czogalla, Regina Feederle, Binje Vick, Irmela Jeremias, Reinhard Zeidler

Journal: Biomedicines

PubMed ID: 35453575

Doi: 10.3390/biomedicines10040825

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Design of protein-binding proteins from the target structure alone

Authors: Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, William Sheffler, Joon Sung Park, Kevin M Jude, Iva Marković, Rameshwar U Kadam, Koen H G Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora Picton, Lauren Miller, Eva-Maria Strauch, Nicholas D DeBouver, Allison Pires, Asim K Bera, Samer Halabiya, Bradley Hammerson, Wei Yang, Steffen Bernard, Lance Stewart, Ian A Wilson, Hannele Ruohola-Baker, Joseph Schlessinger, Sangwon Lee, Savvas N Savvides, K Christopher Garcia, David Baker

Journal: Nature

PubMed ID: 35332283

Doi: 10.1038/s41586-022-04654-9

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Regulator of Actin-Based Motility (RoaM) Downregulates Actin Tail Formation by Rickettsia rickettsii and Is Negatively Selected in Mammalian Cell Culture

Authors: Adam M Nock, Tina R Clark, Ted Hackstadt

Journal: MBio

PubMed ID: 35285700

Doi: 10.1128/mbio.00353-22

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Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor

Authors: Haozhou Tan, Chunlong Ma, Jun Wang

Journal: Res Sq

PubMed ID: 35378761

Doi: 10.21203/rs.3.rs-1490282/v1

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Interleukin-19 Aggravates Pulmonary Fibrosis via Activating Fibroblast through TGF-/Smad Pathway

Authors: Yu Wang, Sibo Sun, Kai Wang, Mingjiong Zhang, Min Li, Yumin Zan, Qiqing Huang, Shuangshuang Wu, Weihong Zhao, Wei Xu, Jianqing Wu

Journal: Mediators Inflamm

PubMed ID: 35281428

Doi: 10.1155/2022/6755407

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Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3-mediated regulation of actin filament assembly into the erythroblast membrane skeleton

Authors: Arit Ghosh, Megan Coffin, Richard West, Velia M Fowler

Journal: FASEB J

PubMed ID: 35195928

Doi: 10.1096/fj.202101011R

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Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine

Authors: Chung-Yi Wu, Cheng-Wei Cheng, Chih-Chuan Kung, Kuo-Shiang Liao, Jia-Tsrong Jan, Che Ma, Chi-Huey Wong

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35149556

Doi: 10.1073/pnas.2119995119

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Superior antitumor immunotherapy efficacy of kynureninase modified CAR-T cells through targeting kynurenine metabolism

Authors: Quanjun Yang, Juan Hao, Mengyi Chi, Yaxian Wang, Bo Xin, Jinglu Huang, Jin Lu, Jie Li, Xipeng Sun, Chunyan Li, Yan Huo, Jianping Zhang, Yonglong Han, Cheng Guo

Journal: Oncoimmunology

PubMed ID: 35355679

Doi: 10.1080/2162402X.2022.2055703

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VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir41/51 Inward Rectifier Potassium Channels

Authors: Samantha J McClenahan, Caitlin N Kent, Sujay V Kharade, Elena Isaeva, Jade C Williams, Changho Han, Andrew Terker, Robert Gresham, Roman M Lazarenko, Emily L Days, Ian M Romaine, Joshua A Bauer, Olivier Boutaud, Gary A Sulikowski, Raymond Harris, C David Weaver, Alexander Staruschenko, Craig W Lindsley, Jerod S Denton

Journal: Mol Pharmacol

PubMed ID: 35246480

Doi: 10.1124/molpharm.121.000464

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Atomic resolution dynamics of cohesive interactions in phase-separated Nup98 FG domains

Authors: Eszter E Najbauer, Sheung Chun Ng, Christian Griesinger, Dirk Görlich, Loren B Andreas

Journal: Nat Commun

PubMed ID: 35314668

Doi: 10.1038/s41467-022-28821-8

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Bmi-1 directly upregulates glucose transporter 1 in human gastric adenocarcinoma

Authors: Ying Guo, Guangyu Zhou, Qingjie Ma, Li Zhang, Jiwei Chen

Journal: Open Life Sci

PubMed ID: 35415241

Doi: 10.1515/biol-2022-0024

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Targeting lipophagy in macrophages improves repair in multiple sclerosis

Authors: Mansour Haidar, Melanie Loix, Sam Vanherle, Tess Dierckx, Tim Vangansewinkel, Pascal Gervois, Esther Wolfs, Ivo Lambrichts, Jeroen F J Bogie, Jerome J A Hendriks

Journal: Autophagy

PubMed ID: 35282773

Doi: 10.1080/15548627.2022.2047343

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Generation of Gal-enhanced bifunctional tumor vaccine

Authors: Jian He, Yu Huo, Zhikun Zhang, Yiqun Luo, Xiuli Liu, Qiaoying Chen, Pan Wu, Wei Shi, Tao Wu, Chao Tang, Huixue Wang, Lan Li, Xiyu Liu, Yong Huang, Yongxiang Zhao, Lu Gan, Bing Wang, Liping Zhong

Journal: Acta Pharm Sin B

PubMed ID: 35865091

Doi: 10.1016/j.apsb.2022.03.002

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Genome sequencing of a novel Microbacterium camelliasinensis CIAB417 identified potential mannan hydrolysing enzymes

Authors: Anjali Purohit, Sudesh Kumar Yadav

Journal: Int J Biol Macromol

PubMed ID: 35331789

Doi: 10.1016/j.ijbiomac.2022.03.093

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A rationally designed synthetic antimicrobial peptide against Pseudomonas-associated corneal keratitis: Structure-function correlation

Authors: Sk Abdul Mohid, Prerana Sharma, Amani Alghalayini, Tripti Saini, Debarun Datta, Mark D P Willcox, Haydar Ali, Sreyan Raha, Achintya Singha, DongKuk Lee, Nirakar Sahoo, Charles G Cranfield, Sanhita Roy, Anirban Bhunia

Journal: Biophys Chem

PubMed ID: 35605494

Doi: 10.1016/j.bpc.2022.106802

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Biodiversity and infrastructure interact to drive tourism to and within Costa Rica

Authors: Alejandra Echeverri, Jeffrey R Smith, Dylan MacArthur-Waltz, Katherine S Lauck, Christopher B Anderson, Rafael Monge Vargas, Irene Alvarado Quesada, Spencer A Wood, Rebecca Chaplin-Kramer, Gretchen C Daily

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35245152

Doi: 10.1073/pnas.2107662119

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Circ_0007611 stimulates IL-1 receptor accessory protein to inhibit trophoblast cell proliferation and induce cell apoptosis

Authors: Haiyan Xing, Qing Ding, Hong Lu, Qun Li

Journal: Biol Reprod

PubMed ID: 35238896

Doi: 10.1093/biolre/ioac028

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Enantioselectivity and key residue of Herbaspirillum huttiense monooxygenase in asymmetric epoxidation of styrenes

Authors: Shuang Dong, Donglin Fan, Qian Liu, Yinyin Meng, Xinyu Liu, Sen Yang, Hui Lin, Na Li, Hongge Chen

Journal: Appl Microbiol Biotechnol

PubMed ID: 35230494

Doi: 10.1007/s00253-022-11843-z

Products & Services: Proteins, Expression, Isolation and Analysis

Structural polymorphism of coiled-coils from the stalk domain of SARS-CoV-2 spike protein

Authors: Zala Živič, Žiga Strmšek, Marko Novinec, Jurij Lah, San Hadži

Journal: FASEB J

PubMed ID: 35157347

Doi: 10.1096/fj.202101670R

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Heat Shock Protein A6 Is Especially Involved in Enterovirus 71 Infection

Authors: Jiaoyan Jia, Ge Liu, Jianfeng Zhong, Ran Yan, Xun Song, Kai Zheng, Zhe Ren, Zhendan He, Qinchang Zhu

Journal: Front Microbiol

PubMed ID: 35308396

Doi: 10.3389/fmicb.2022.865644

Products & Services: Proteins, Expression, Isolation and Analysis

Pervasive translation in

Authors: Carol Smith, Jill G Canestrari, Archer J Wang, Matthew M Champion, Keith M Derbyshire, Todd A Gray, Joseph T Wade

Journal: Elife

PubMed ID: 35343439

Doi: 10.7554/eLife.73980

Products & Services: Proteins, Expression, Isolation and Analysis

Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior

Authors: Mikkel Bloss Carstensen, Adar Medvetzky, Alon Weinberger, Wolfgang Driever, Yoav Gothilf, Martin Fredensborg Rath

Journal: J Pineal Res

PubMed ID: 35249239

Doi: 10.1111/jpi.12795

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oligosaccharides increase serotonin in the brain and ameliorate depression promoting 5-hydroxytryptophan production in the gut microbiota

Authors: Zheng-Wei Zhang, Chun-Sheng Gao, Heng Zhang, Jian Yang, Ya-Ping Wang, Li-Bin Pan, Hang Yu, Chi-Yu He, Hai-Bin Luo, Zhen-Xiong Zhao, Xin-Bo Zhou, Yu-Li Wang, Jie Fu, Pei Han, Yu-Hui Dong, Gang Wang, Song Li, Yan Wang, Jian-Dong Jiang, Wu Zhong

Journal: Acta Pharm Sin B

PubMed ID: 35967282

Doi: 10.1016/j.apsb.2022.02.032

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Activation mechanism of the class D fungal GPCR dimer Ste2

Authors: Vaithish Velazhahan, Ning Ma, Nagarajan Vaidehi, Christopher G Tate

Journal: Nature

PubMed ID: 35296853

Doi: 10.1038/s41586-022-04498-3

Products & Services: Proteins, Expression, Isolation and Analysis

Nephronectin-integrin α8 signaling is required for proper migration of periocular neural crest cells during chick corneal development

Authors: Justin Ma, Lian Bi, James Spurlin, Peter Lwigale

Journal: Elife

PubMed ID: 35238772

Doi: 10.7554/eLife.74307

Products & Services: PCR Cloning and Subcloning

Antibodies Targeting KSHV gH/gL Reveal Distinct Neutralization Mechanisms

Authors: Thomas Fricke, Anna K Großkopf, Armin Ensser, Marija Backovic, Alexander S Hahn

Journal: Viruses

PubMed ID: 35336948

Doi: 10.3390/v14030541

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Directed evolution of adeno-associated virus 5 capsid enables specific liver tropism

Authors: Yuqiu Wang, Chen Yang, Hanyang Hu, Chen Chen, Mengdi Yan, Feixiang Ling, Kathy Cheng Wang, Xintao Wang, Zhe Deng, Xinyue Zhou, Feixu Zhang, Sen Lin, Zengmin Du, Kai Zhao, Xiao Xiao

Journal: Mol Ther Nucleic Acids

PubMed ID: 35474733

Doi: 10.1016/j.omtn.2022.03.017

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Specificity and Reactivity of Serine/Threonine Kinases PknG and PknB

Authors: Osvaldo Burastero, Marisol Cabrera, Elias D Lopez, Lucas A Defelipe, Juan Pablo Arcon, Rosario Durán, Marcelo A Marti, Adrian G Turjanski

Journal: J Chem Inf Model

PubMed ID: 35319884

Doi: 10.1021/acs.jcim.1c01358

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A novel silk fibroin protein-based fusion system for enhancing the expression of nanobodies in Escherichia coli

Authors: Jianli Yu, Yang Guo, Yi Gu, Xiying Fan, Fei Li, Haipeng Song, Rui Nian, Wenshuai Liu

Journal: Appl Microbiol Biotechnol

PubMed ID: 35243528

Doi: 10.1007/s00253-022-11857-7

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Treatment Regimens for Transplant-Ineligible Patients With Newly Diagnosed Multiple Myeloma: A Systematic Literature Review and Network Meta-analysis

Authors: Thierry Facon, Jesús San-Miguel, Meletios A Dimopoulos, Maria-Victoria Mateos, Michele Cavo, Sophie van Beekhuizen, Zijiao Yuan, João Mendes, Annette Lam, Jianming He, Eric Ammann, Shaji Kumar

Journal: Adv Ther

PubMed ID: 35246820

Doi: 10.1007/s12325-022-02083-8

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Molnupiravir and Nirmatrelvir-Ritonavir: Oral COVID Antiviral Drugs

Authors: Louis D Saravolatz, Shawn Depcinski, Mamta Sharma

Journal: Clin Infect Dis

PubMed ID: 35245942

Doi: 10.1093/cid/ciac180

Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane Fusion

Authors: Chia-Jung Li, Tai-Ling Chao, Ting-Yu Chang, Chia-Chun Hsiao, De-Chao Lu, Yi-Wei Chiang, Guan-Chun Lai, Ya-Min Tsai, Jun-Tung Fang, Siman Ieong, Jann-Tay Wang, Sui-Yuan Chang, Shih-Chung Chang

Journal: Microbiol Spectr

PubMed ID: 35293796

Doi: 10.1128/spectrum.01814-21

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Characterization of UDP-glycosyltransferase family members reveals how major flavonoid glycoside accumulates in the roots of Scutellaria baicalensis

Authors: Tianlin Pei, Mengxiao Yan, Tian Li, Xiaoqiang Li, Yijia Yin, Mengying Cui, Yumin Fang, Jie Liu, Yu Kong, Ping Xu, Qing Zhao

Journal: BMC Genomics

PubMed ID: 35232374

Doi: 10.1186/s12864-022-08391-1

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Two independent cis-acting elements are required for the guard cell-specific expression of SCAP1, which is essential for late stomatal development

Authors: Kosuke Moriwaki, Shuichi Yanagisawa, Koh Iba, Juntaro Negi

Journal: Plant J

PubMed ID: 35061307

Doi: 10.1111/tpj.15679

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Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model

Authors: Julie A Zorn, Matthew L Wheeler, Ralston M Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y-C Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop

Journal: Sci Rep

PubMed ID: 35241687

Doi: 10.1038/s41598-022-06953-7

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Theileria equi RAP-1a and RAP-1b proteins contain immunoreactive epitopes and are suitable candidates for vaccine and diagnostics development

Authors: Cynthia K Onzere, Lindsay M Fry, Richard P Bishop, Marta Da Silva, Sally A Madsen-Bouterse, Reginaldo G Bastos, Donald P Knowles, Carlos E Suarez

Journal: Int J Parasitol

PubMed ID: 35318949

Doi: 10.1016/j.ijpara.2022.01.004

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Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF melanoma

Authors: Lorey K Smith, Tiffany Parmenter, Margarete Kleinschmidt, Eric P Kusnadi, Jian Kang, Claire A Martin, Peter Lau, Riyaben Patel, Julie Lorent, David Papadopoli, Anna Trigos, Teresa Ward, Aparna D Rao, Emily J Lelliott, Karen E Sheppard, David Goode, Rodney J Hicks, Tony Tiganis, Kaylene J Simpson, Ola Larsson, Benjamin Blythe, Carleen Cullinane, Vihandha O Wickramasinghe, Richard B Pearson, Grant A McArthur

Journal: Nat Commun

PubMed ID: 35232962

Doi: 10.1038/s41467-022-28705-x

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Development of a p72 trimer-based colloidal gold strip for detection of antibodies against African swine fever virus

Authors: Rui Geng, Yaning Sun, Rui Li, Jifei Yang, Hongfang Ma, Zixuan Qiao, Qingxia Lu, Songlin Qiao, Gaiping Zhang

Journal: Appl Microbiol Biotechnol

PubMed ID: 35291024

Doi: 10.1007/s00253-022-11851-z

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Baohuoside I Inhibits Tumor Angiogenesis in Multiple Myeloma the Peroxisome Proliferator-Activated Receptor γ/Vascular Endothelial Growth Factor Signaling Pathway

Authors: Ying Chen, Lina Zhang, Xiaoyan Zang, Xuxing Shen, Jianyong Li, Lijuan Chen

Journal: Front Pharmacol

PubMed ID: 35341213

Doi: 10.3389/fphar.2022.822082

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Development and Validation of a Competitive ELISA Based on Bovine Monoclonal Antibodies for the Detection of Neutralizing Antibodies against Foot-and-Mouth Disease Virus Serotype A

Authors: Yimei Cao, Kun Li, Xiangchuan Xing, Guoqiang Zhu, Yuanfang Fu, Huifang Bao, Xingwen Bai, Pu Sun, Pinghua Li, Jing Zhang, Xueqing Ma, Jian Wang, Zhixun Zhao, Dong Li, Zaixin Liu, Zengjun Lu

Journal: J Clin Microbiol

PubMed ID: 35254106

Doi: 10.1128/jcm.02142-21

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Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy

Authors: Juan Qin, Jingfeng Zhang, Lianyun Lin, Omid Haji-Ghassemi, Zhi Lin, Kenneth J Woycechowsky, Filip Van Petegem, Yan Zhang, Zhiguang Yuchi

Journal: Elife

PubMed ID: 35297759

Doi: 10.7554/eLife.75346

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ClpX/P-Dependent Degradation of Novel Substrates in Streptococcus mutans

Authors: Vivek Gurung, Indranil Biswas

Journal: J Bacteriol

PubMed ID: 35343773

Doi: 10.1128/jb.00594-21

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Restriction of viral gene expression and replication prevents immortalization of human keratinocytes by a beta-human papillomavirus

Authors: Tina M Rehm, Elke Straub, Thomas Iftner, Frank Stubenrauch

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35254896

Doi: 10.1073/pnas.2118930119

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Predictable NHEJ Insertion and Assessment of HDR Editing Strategies in Plants

Authors: Kutubuddin A Molla, Justin Shih, Matthew S Wheatley, Yinong Yang

Journal: Front Genome Ed

PubMed ID: 35481279

Doi: 10.3389/fgeed.2022.825236

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COVID-19 Convalescent Plasma and Clinical Trials: Understanding Conflicting Outcomes

Authors: Daniele Focosi, Massimo Franchini, Liise-Anne Pirofski, Thierry Burnouf, Nigel Paneth, Michael J Joyner, Arturo Casadevall

Journal: Clin Microbiol Rev

PubMed ID: 35262370

Doi: 10.1128/cmr.00200-21

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Engineering Saccharomyces cerevisiae for the production and secretion of Affibody molecules

Authors: Veronica Gast, Anna Sandegren, Finn Dunås, Siri Ekblad, Rezan Güler, Staffan Thorén, Marta Tous Mohedano, Mikael Molin, Martin K M Engqvist, Verena Siewers

Journal: Microb Cell Fact

PubMed ID: 35264156

Doi: 10.1186/s12934-022-01761-0

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MiR-183-5p overexpression in bone mesenchymal stem cell-derived exosomes protects against myocardial ischemia/reperfusion injury by targeting FOXO1

Authors: Shuai Mao, Jing Zhao, Zhao-Juan Zhang, Qin Zhao

Journal: Immunobiology

PubMed ID: 35314383

Doi: 10.1016/j.imbio.2022.152204

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Inactivated SARS-CoV-2 vaccine in primary Sjögren's syndrome: humoral response, safety, and effects on disease activity

Authors: Sandra Gofinet Pasoto, Ari Stiel Radu Halpern, Lissiane Karine Noronha Guedes, Ana Cristina Medeiros Ribeiro, Emily Neves Figueiredo Yuki, Carla Gonçalves Schahin Saad, Clovis Artur Almeida da Silva, Léonard de Vinci Kanda Kupa, Lorena Elizabeth Betancourt Villamarín, Victor Adriano de Oliveira Martins, Carolina Campagnoli Machado Freire Martins, Giordano Bruno Henriques Deveza, Elaine Pires Leon, Cleonice Bueno, Tatiana Nascimento Pedrosa, Roseli Eliana Beseggio Santos, Renata Soares, Nádia Emi Aikawa, Eloisa Bonfa

Journal: Clin Rheumatol

PubMed ID: 35306594

Doi: 10.1007/s10067-022-06134-x

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METTL14-mediated N6-methyladenosine modification of Pten mRNA inhibits tumour progression in clear-cell renal cell carcinoma

Authors: Lili Zhang, Xiaofang Luo, Sen Qiao

Journal: Br J Cancer

PubMed ID: 35249103

Doi: 10.1038/s41416-022-01757-y

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A TCR mimic monoclonal antibody reactive with the "public" phospho-neoantigen pIRS2/HLA-A*02:01 complex

Authors: Tao Dao, Sung Soo Mun, Zaki Molvi, Tatyana Korontsvit, Martin G Klatt, Abdul G Khan, Elisabeth K Nyakatura, Mary Ann Pohl, Thomas E White, Paul J Balderes, Ivo C Lorenz, Richard J O'Reilly, David A Scheinberg

Journal: JCI Insight

PubMed ID: 35260532

Doi: 10.1172/jci.insight.151624

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Elucidating the Novel Mechanism of Ligustrazine in Preventing Postoperative Peritoneal Adhesion Formation

Authors: Lili Yang, Zhengjun Li, Yao Chen, Feiyan Chen, Haopeng Sun, Min Zhao, Yanqi Chen, Yali Wang, Wenlin Li, Li Zeng, Yaoyao Bian

Journal: Oxid Med Cell Longev

PubMed ID: 35308169

Doi: 10.1155/2022/9226022

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Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway

Authors: Yang Bai, Jiaqi Chen, Weijian Hu, Lei Wang, Yulian Wu, Shi'an Yu

Journal: Front Pharmacol

PubMed ID: 35401195

Doi: 10.3389/fphar.2022.847905

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Function and Application of the CRISPR-Cas System in the Plant Pathogen

Authors: Michael Parcey, Steven Gayder, Alan J Castle, Antonet M Svircev

Journal: Appl Environ Microbiol

PubMed ID: 35285707

Doi: 10.1128/aem.02513-21

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Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus

Authors: Douglas N Brawley, David B Sauer, Jianping Li, Xuhui Zheng, Akiko Koide, Ganesh S Jedhe, Tiffany Suwatthee, Jinmei Song, Zheng Liu, Paramjit S Arora, Shohei Koide, Victor J Torres, Da-Neng Wang, Nathaniel J Traaseth

Journal: Nat Chem Biol

PubMed ID: 35361990

Doi: 10.1038/s41589-022-00994-9

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Peptide mediated, enhanced toxicity of a bacterial pesticidal protein against southern green stink bug

Authors: Rahul Banerjee, Biviana Flores-Escobar, Nanasaheb P Chougule, Pablo Emiliano Cantón, Razvan Dumitru, Bryony C Bonning

Journal: Microb Biotechnol

PubMed ID: 35315236

Doi: 10.1111/1751-7915.14030

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α-Melanocyte-stimulating hormone inhibition of oxytocin neurons switches to excitation in late pregnancy and lactation

Authors: Michael R Perkinson, Matthew K Kirchner, Meng Zhang, Rachael A Augustine, Javier E Stern, Colin H Brown

Journal: Physiol Rep

PubMed ID: 35312181

Doi: 10.14814/phy2.15226

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N-gene-complementary antisense-oligonucleotide directed molecular aggregation of dual-colour carbon dots, leading to efficient fluorometric sensing of SARS-COV-2 RNA

Authors: Zach Sheffield, Maha Alafeef, Parikshit Moitra, Priyanka Ray, Dipanjan Pan

Journal: Nanoscale

PubMed ID: 35297914

Doi: 10.1039/d1nr07169f

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Structural Basis for Human Receptor Recognition by SARS-CoV-2 Omicron Variant BA1

Authors: Qibin Geng, Ke Shi, Gang Ye, Wei Zhang, Hideki Aihara, Fang Li

Journal: J Virol

PubMed ID: 35343765

Doi: 10.1128/jvi.00249-22

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Glutathione binding to the plant Atm3 transporter and implications for the conformational coupling of ABC transporters

Authors: Chengcheng Fan, Douglas C Rees

Journal: Elife

PubMed ID: 35333177

Doi: 10.7554/eLife.76140

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Cellular assays identify barriers impeding iron-sulfur enzyme activity in a non-native prokaryotic host

Authors: Francesca D'Angelo, Elena Fernández-Fueyo, Pierre Simon Garcia, Helena Shomar, Martin Pelosse, Rita Rebelo Manuel, Ferhat Büke, Siyi Liu, Niels van den Broek, Nicolas Duraffourg, Carol de Ram, Martin Pabst, Emmanuelle Bouveret, Simonetta Gribaldo, Béatrice Py, Sandrine Ollagnier de Choudens, Frédéric Barras, Gregory Bokinsky

Journal: Elife

PubMed ID: 35244541

Doi: 10.7554/eLife.70936

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A jacalin-like lectin domain-containing protein of Sclerospora graminicola acts as an apoplastic virulence effector in plant-oomycete interactions

Authors: Michie Kobayashi, Hiroe Utsushi, Koki Fujisaki, Takumi Takeda, Tetsuro Yamashita, Ryohei Terauchi

Journal: Mol Plant Pathol

PubMed ID: 35257477

Doi: 10.1111/mpp.13197

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Assay design for unambiguous identification and quantification of circulating pathogen-derived peptide biomarkers

Authors: Qingbo Shu, Shan Liu, Tonino Alonzi, Sylvia M LaCourse, Dhiraj Kumar Singh, Duran Bao, Dalton Wamalwa, Li Jiang, Christopher J Lyon, Grace John-Stewart, Deepak Kaushal, Delia Goletti, Tony Hu

Journal: Theranostics

PubMed ID: 35401822

Doi: 10.7150/thno.70373

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Engineering a synthesis-friendly serum responsive promoter for antibiotic selection of genomic integration in cell-based therapy

Authors: Chee Ka Candice Lam, Kevin Truong

Journal: Biotechnol Lett

PubMed ID: 35294696

Doi: 10.1007/s10529-022-03244-z

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CRISPR/Cas9-Based Mutagenesis of Histone H31 in Spinal Dynorphinergic Neurons Attenuates Thermal Sensitivity in Mice

Authors: Zoltán Mészár, Éva Kókai, Rita Varga, László Ducza, Tamás Papp, Monika Béresová, Marianna Nagy, Péter Szücs, Angelika Varga

Journal: Int J Mol Sci

PubMed ID: 35328599

Doi: 10.3390/ijms23063178

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Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling

Authors: Kelly J Culhane, Tejas M Gupte, Indrani Madhugiri, Chetan J Gadgil, Sivaraj Sivaramakrishnan

Journal: Nat Commun

PubMed ID: 35260563

Doi: 10.1038/s41467-022-28789-5

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Self-amplifying mRNA SARS-CoV-2 vaccines raise cross-reactive immune response to variants and prevent infection in animal models

Authors: Giuseppe Palladino, Cheng Chang, Changkeun Lee, Nedzad Music, Ivna De Souza, Jonathan Nolasco, Samuel Amoah, Pirada Suphaphiphat, Gillis R Otten, Ethan C Settembre, Yingxia Wen

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35345593

Doi: 10.1016/j.omtm.2022.03.013

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Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY

Authors: Ninako Kimura, Kanako Saito, Takashi Niwa, Masato Yamakawa, Shota Igaue, Junko Ohkanda, Takamitsu Hosoya, Isao Kii

Journal: Protein Expr Purif

PubMed ID: 35307559

Doi: 10.1016/j.pep.2022.106089

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