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Chemical and enzymatic modifications of 5- methylcytosine at the intersection of DNA damage, repair, and epigenetic reprogramming

Authors: Tuvshintugs Baljinnyam , Mark L Sowers , Chia Wei Hsu , James W Conrad , Jason L Herring , Linda C Hackfeld , Lawrence C Sowers

Journal: PLoS ONE

PubMed ID: 0273509

Doi: 10.1371/journal.pone.0273509

Products & Services: Plasmid DNA Preparation

Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

Authors: Laura J Stevens, Andrea J Pruijssers, Hery W Lee, Calvin J Gordon, Egor P Tchesnokov, Jennifer Gribble, Amelia S George, Tia M Hughes, Xiaotao Lu, Jiani Li, Jason K Perry, Danielle P Porter, Tomas Cihlar, Timothy P Sheahan, Ralph S Baric, Matthias Götte, Mark R Denison

Journal: Sci Transl Med

PubMed ID: 35482820

Doi: 10.1126/scitranslmed.abo0718

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assessment of simultaneous G1 cyclins silencing by a tumor-specific bidirectional promoter on the mammary tumor in nude mice

Authors: Gholamreza Mesbah, Fatemeh Namazi, Fatemeh T Shamsabadi, Zahra Maleki, Mehrab Nasirikenari, Majid Shahbazi

Journal: Front Vet Sci

PubMed ID: 36072388

Doi: 10.3389/fvets.2022.914311

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Structures of topoisomerase V in complex with DNA reveal unusual DNA-binding mode and novel relaxation mechanism

Authors: Amy Osterman, Alfonso Mondragón

Journal: Elife

PubMed ID: 35969036

Doi: 10.7554/eLife.72702

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The Catalytic Subunit of CK2 (Cka1) Negatively Regulates RNA Polymerase II Transcription through Phosphorylation of Positive Cofactor 4 (PC4)

Authors: Diego A Rojas, Fabiola Urbina, Aldo Solari, Edio Maldonado

Journal: Int J Mol Sci

PubMed ID: 36012759

Doi: 10.3390/ijms23169499

Products & Services: Mutant Libraries

Transcriptional changes in LMH cells induced by rhoptry kinase family protein 17

Authors: Yi-Jing Meng, Bing-Jin Mu, Xiao-Xin Liu, Lin-Mei Yu, Wen-Bin Zheng, Shi-Chen Xie, Wen-Wei Gao, Xing-Quan Zhu, Qing Liu

Journal: Front Vet Sci

PubMed ID: 36016802

Doi: 10.3389/fvets.2022.956040

Products & Services: Protein and Antibody Isolation

Structural basis for receptor selectivity and inverse agonism in S1P receptors

Authors: Elizaveta Lyapina, Egor Marin, Anastasiia Gusach, Philipp Orekhov, Andrey Gerasimov, Aleksandra Luginina, Daniil Vakhrameev, Margarita Ergasheva, Margarita Kovaleva, Georgii Khusainov, Polina Khorn, Mikhail Shevtsov, Kirill Kovalev, Sergey Bukhdruker, Ivan Okhrimenko, Petr Popov, Hao Hu, Uwe Weierstall, Wei Liu, Yunje Cho, Ivan Gushchin, Andrey Rogachev, Gleb Bourenkov, Sehan Park, Gisu Park, Hyo Jung Hyun, Jaehyun Park, Valentin Gordeliy, Valentin Borshchevskiy, Alexey Mishin, Vadim Cherezov

Journal: Nat Commun

PubMed ID: 35961984

Doi: 10.1038/s41467-022-32447-1

Products & Services: Mammalian Expression

Strong T-cell activation in response to COVID-19 vaccination in multiple sclerosis patients receiving B-cell depleting therapies

Authors: Roberto Alfonso-Dunn, Jerry Lin, Vanessa Kirschner, Joyce Lei, Grant Feuer, Michaela Malin, Jiayuan Liu, Morgan Roche, Saud A Sadiq

Journal: Front Immunol

PubMed ID: 35990701

Doi: 10.3389/fimmu.2022.926318

EmCyclinD-EmCDK4/6 complex is involved in the host EGF-mediated proliferation of germinative cells the EGFR-ERK pathway

Authors: Chonglv Feng, Zhe Cheng, Zhijian Xu, Ye Tian, Huimin Tian, Fan Liu, Damin Luo, Yanhai Wang

Journal: Front Microbiol

PubMed ID: 36033888

Doi: 10.3389/fmicb.2022.968872

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A context-dependent and disordered ubiquitin-binding motif

Authors: Jesper E Dreier, Andreas Prestel, João M Martins, Sebastian S Brøndum, Olaf Nielsen, Anna E Garbers, Hiroaki Suga, Wouter Boomsma, Joseph M Rogers, Rasmus Hartmann-Petersen, Birthe B Kragelund

Journal: Cell Mol Life Sci

PubMed ID: 35974206

Doi: 10.1007/s00018-022-04486-w

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The nuclear receptor TLX (NR2E1) inhibits growth and progression of triple- negative breast cancer

Authors: Adam T Nelczyk, Liqian Ma, Anasuya Das Gupta, Hashni Epa Vidana Gamage, Michael T McHenry, Madeline A Henn, Mohammed Kadiri, Yu Wang, Natalia Krawczynska, Shruti Bendre, Sisi He, Sayyed Hamed Shahoei, Zeynep Madak-Erdogan, Shih-Hsuan Hsiao, Tareq Saleh, Valerie Carpenter, David A Gewirtz, Michael J Spinella, Erik R Nelson

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 35932893

Doi: 10.1016/j.bbadis.2022.166515

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Severe congenital myasthenic syndromes caused by agrin mutations affecting secretion by motoneurons

Authors: Arnaud Jacquier, Valérie Risson, Thomas Simonet, Florine Roussange, Nicolas Lacoste, Shams Ribault, Julien Carras, Julian Theuriet, Emmanuelle Girard, Isabelle Grosjean, Laure Le Goff, Stephan Kröger, Julia Meltoranta, Stéphanie Bauché, Damien Sternberg, Emmanuel Fournier, Anna Kostera-Pruszczyk, Emily O'Connor, Bruno Eymard, Hanns Lochmüller, Cécile Martinat, Laurent Schaeffer

Journal: Acta Neuropathol

PubMed ID: 35948834

Doi: 10.1007/s00401-022-02475-8

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CGG repeats trigger translational frameshifts that generate aggregation-prone chimeric proteins

Authors: Shannon E Wright, Caitlin M Rodriguez, Jeremy Monroe, Jiazheng Xing, Amy Krans, Brittany N Flores, Venkatesha Barsur, Magdalena I Ivanova, Kristin S Koutmou, Sami J Barmada, Peter K Todd

Journal: Nucleic Acids Res

PubMed ID: 35904811

Doi: 10.1093/nar/gkac626

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latent liver infection is characterized by persistent hypnozoites, hypnozoite-derived schizonts, and time-dependent efficacy of primaquine

Authors: Erika L Flannery, Niwat Kangwanrangsan, Vorada Chuenchob, Wanlapa Roobsoong, Matthew Fishbaugher, Kevin Zhou, Zachary P Billman, Thomas Martinson, Tayla M Olsen, Carola Schäfer, Brice Campo, Sean C Murphy, Sebastian A Mikolajczak, Stefan H I Kappe, Jetsumon Sattabongkot

Journal: Mol Ther Methods Clin Dev

PubMed ID: 36092359

Doi: 10.1016/j.omtm.2022.07.016

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The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation

Authors: Kohei Kusakari, Takeshi Machida, Yumi Ishida, Tomoko Omori, Toshiyuki Suzuki, Masayuki Sekimata, Ikuo Wada, Teizo Fujita, Hideharu Sekine

Journal: Front Immunol

PubMed ID: 36052069

Doi: 10.3389/fimmu.2022.907023

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Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP

Authors: Takeshi Yokoyama, Shiho Fujii, Andreas Ostermann, Tobias E Schrader, Yuko Nabeshima, Mineyuki Mizuguchi

Journal: IUCrJ

PubMed ID: 36071806

Doi: 10.1107/S2052252522006297

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Surface cysteine to serine substitutions in IL-18 reduce aggregation and enhance activity

Authors: Jirakrit Saetang, Niran Roongsawang, Surasak Sangkhathat, Supayang Piyawan Voravuthikunchai, Natnaree Sangkaew, Napat Prompat, Teerapol Srichana, Varomyalin Tipmanee

Journal: PeerJ

PubMed ID: 35811828

Doi: 10.7717/peerj.13626

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Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA

Authors: Qiuxia Chen, You Li, Chunrong Lin, Liu Chen, Hao Luo, Shuai Xia, Chuan Liu, Xuemin Cheng, Chengzhong Liu, Jin Li, Dengfeng Dou

Journal: Nucleic Acids Res

PubMed ID: 35288754

Doi: 10.1093/nar/gkac173

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The role of CFA/I in adherence and toxin delivery by ETEC expressing multiple colonization factors in the human enteroid model

Authors: Emily M Smith, Christen L Grassel, Antonia Papadimas, Jennifer Foulke-Abel, Eileen M Barry

Journal: PLoS Negl Trop Dis

PubMed ID: 35881640

Doi: 10.1371/journal.pntd.0010638

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Insight into bacterial community profiles of oil shale and sandstone in ordos basin by culture-dependent and culture-independent methods

Authors: Fengdan Wei, Rui Xu, Yuanyuan Xu, Tao Cheng, Yanling Ma

Journal: J Environ Sci Health A Tox Hazard Subst Environ Eng

PubMed ID: 35903918

Doi: 10.1080/10934529.2022.2105631

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Enhancing epitope of PEDV spike protein

Authors: Techit Thavorasak, Monrat Chulanetra, Kittirat Glab-Ampai, Kodchakorn Mahasongkram, Nawannaporn Sae-Lim, Karsidete Teeranitayatarn, Thaweesak Songserm, Rungrueang Yodsheewan, Dachrit Nilubol, Wanpen Chaicumpa, Nitat Sookrung

Journal: Front Microbiol

PubMed ID: 35935230

Doi: 10.3389/fmicb.2022.933249

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Self-Assembling Protein Surfaces for Capture of Cell-Free-Synthesized Proteins

Authors: Ella Lucille Thornton, Sarah Maria Paterson, Zoe Gidden, Mathew H Horrocks, Nadanai Laohakunakorn, Lynne Regan

Journal: Front Bioeng Biotechnol

PubMed ID: 35875503

Doi: 10.3389/fbioe.2022.915035

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Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals

Authors: Chenxi Wang, Runkang Qu, Yanan Zong, Chao Qin, Litao Liu, Xiaoyi Gao, Honglei Sun, Yipeng Sun, Kin-Chow Chang, Rui Zhang 1 , Jinhua Liu 1 , Juan Pu 1

Journal: PLoS Pathog

PubMed ID: 35793327

Doi: 10.1371/journal.ppat.1010645

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Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1

Authors: Yu Jin , Zhen Liu , Zhenxia Li , Hairui Li , Cheng Zhu , Ruomei Li , Ting Zhou , Bing Fang

Journal: Int J Oral Sci

PubMed ID: 35831280

Doi: 10.1038/s41368-022-00190-4

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Simultaneous quantification of SMN1 and SMN2 copy numbers by MALDI-TOF mass spectrometry for spinal muscular atrophy genetic testing

Authors: Weijiang Jin , Zhengquan Yang , Xiaojun Tang , Xiuchao Wang , Yaxin Huang , Chenmin Hui , Jiaming Yao , Ju Luan , Shaohua Tang , Shengnan Wu , Shengnan Jin , Chunming Ding

Journal: Clin Chim Acta

PubMed ID: 35643151

Doi: 10.1016/j.cca.2022.05.017

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PTPRO knockdown protects against inflammation in hemorrhage shock-induced lung injury involving the NF-κB signaling pathway

Authors: Zhirong Huan, Ying Tang, Ce Xu, Jimin Cai, Hao Yao, Yan Wang, Fanyu Bu, Xin Ge

Journal: Respir Res

PubMed ID: 35906634

Doi: 10.1186/s12931-022-02118-2

Products & Services: Mammalian Expression

Membrane fluidity, composition, and charge affect the activity and selectivity of the AMP ascaphin-8

Authors: Adriana Morales-Martínez, Brandt Bertrand, Juan M Hernández-Meza, Ramón Garduño-Juárez, Jesús Silva-Sanchez, Carlos Munoz-Garay

Journal: Biophys J

PubMed ID: 35842753

Doi: 10.1016/j.bpj.2022.07.018

Products & Services: Catalog Gene Editing

Construction of a T7 phage display nanobody library for bio-panning and identification of chicken dendritic cell-specific binding nanobodies

Authors: Hai Xu, Ling Li, Bihua Deng, Weiming Hong, Ruiting Li, Zijie Guo, Jibo Hou, Roshini Govinden, Hafizah Y Chenia

Journal: Sci Rep

PubMed ID: 35840654

Doi: 10.1038/s41598-022-16378-x

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Ca attenuates nucleation activity of leiomodin

Authors: Garry E Smith, Dmitri Tolkatchev, Cristina Risi, Madison Little, Carol C Gregorio, Vitold E Galkin, Alla S Kostyukova

Journal: Protein Sci

PubMed ID: 35762710

Doi: 10.1002/pro.4358

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Engineering a tunable bicistronic TetR autoregulation expression system in

Authors: Monica Bertucci, Ky Ariano, Meg Zumsteg, Paul Schweiger

Journal: PeerJ

PubMed ID: 35873911

Doi: 10.7717/peerj.13639

Products & Services: PCR Cloning and Subcloning

A Single Vaccination of Chimeric Bivalent Virus-Like Particle Vaccine Confers Protection Against H9N2 and H3N2 Avian Influenza in Commercial Broilers and Allows a Strategy of Differentiating Infected from Vaccinated Animals

Authors: Yi-Xue Sun, Zheng-Rong Li, Peng-Ju Zhang, Jin-Hong Han, Hai-Yang Di, Jia-Yi Qin, Yan-Long Cong

Journal: Front Immunol

PubMed ID: 35874682

Doi: 10.3389/fimmu.2022.902515

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Golgin Subfamily A Member 5 Is Essential for Production of Extracellular Matrix Proteins during TGF-1-Induced Periodontal Ligament-Fibroblastic Differentiation

Authors: Hyun-Jin Kim, Seong-Min Kim, Min-Jeong Choi, Young-Joo Jang

Journal: Stem Cells Int

PubMed ID: 35879965

Doi: 10.1155/2022/3273779

Products & Services: Mammalian Expression

Urinary CD8+HLA-DR+ T Cell Abundance Non-invasively Predicts Kidney Transplant Rejection

Authors: Emil Grothgar, Nina Goerlich, Bjoern Samans, Christopher M Skopnik, Diana Metzke, Jan Klocke, Luka Prskalo, Paul Freund, Leonie Wagner, Michael Duerr, Mareen Matz, Sven Olek, Klemens Budde, Alexander Paliege, Philipp Enghard

Journal: Front Med (Lausanne)

PubMed ID: 35911418

Doi: 10.3389/fmed.2022.928516

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Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition

Authors: Elena G Govorunova , Yueyang Gou , Oleg A Sineshchekov , Hai Li , Xiaoyu Lu , Yumei Wang , Leonid S Brown , François St-Pierre , Mingshan Xue , John L Spudich

Journal: Nature neuroscience

PubMed ID: 35726059

Doi: 10.1038/s41593-022-01094-6

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Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus

Authors: Francesco Aulicino, Martin Pelosse, Christine Toelzer, Julien Capin, Erwin Ilegems, Parisa Meysami, Ruth Rollarson, Per-Olof Berggren, Mark Simon Dillingham, Christiane Schaffitzel, Moin A Saleem, Gavin I Welsh, Imre Berger

Journal: Nucleic Acids Res

PubMed ID: 35801912

Doi: 10.1093/nar/gkac587

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Durability of the Neutralizing Antibody Response to mRNA Booster Vaccination Against SARS-CoV-2 BA2121 and BA4/5 Variants

Authors: Panke Qu, Julia N Faraone, John P Evans, Yi-Min Zheng, Claire Carlin, Gerard Lozanski, Linda J Saif, Eugene M Oltz, Richard J Gumina, Shan-Lu Liu

Journal: biorxiv

PubMed ID: 35898337

Doi: 10.1101/2022.07.21.501010

Products & Services: Plasmid DNA Preparation

Impact of the temperature on the interactions between common variants of the SARS-CoV-2 receptor binding domain and the human ACE2

Authors: Catherine Forest-Nault, Izel Koyuturk, Jimmy Gaudreault, Alex Pelletier, Denis L'Abbé, Brian Cass, Louis Bisson, Alina Burlacu, Laurence Delafosse, Matthew Stuible, Olivier Henry, Gregory De Crescenzo, Yves Durocher

Journal: Sci Rep

PubMed ID: 35798770

Doi: 10.1038/s41598-022-15215-5

Products & Services: Mammalian Expression

Limited Correlation between SARS-CoV-2 Serologic Assays for Identification of High-Titer COVID-19 Convalescent Plasma Using FDA Thresholds

Authors: Nicholas E Larkey, Radwa Ewaisha, Michael A Lasho, Matthew M Roforth, Dane Granger, Calvin R Jerde, Liang Wu, Amy Gorsh, Stephen A Klassen, Jonathon W Senefeld, Michael J Joyner, Nikola A Baumann, Elitza S Theel, John R Mills

Journal: Microbiol Spectr

PubMed ID: 35862939

Doi: 10.1128/spectrum.01154-22

Pro-Survival Factor EDEM3 Confers Therapy Resistance in Prostate Cancer

Authors: Emma Scott, Rebecca Garnham, Kathleen Cheung, Adam Duxfield, David J Elliott, Jennifer Munkley

Journal: Int J Mol Sci

PubMed ID: 35897761

Doi: 10.3390/ijms23158184

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An adaptable platform for in-house hepatitis C serology

Authors: Jannie Pedersen, Irène Pegha Moukandja, Stella Ndidi, Anna-Louise Sørensen, Ismaël Hervé Koumakpayi, Jean-Bernard Lekana-Douki, Marie-Louise Vachon, Nina Weis, Gary Kobinger, Hugues Fausther-Bovendo

Journal: J Virol Methods

PubMed ID: 35850366

Doi: 10.1016/j.jviromet.2022.114586

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Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2

Authors: Brandon Wey-Hung Liauw, Arash Foroutan, Michael R Schamber, Weifeng Lu, Hamid Samareh Afsari, Reza Vafabakhsh

Journal: Elife

PubMed ID: 35775730

Doi: 10.7554/eLife.78982

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Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains

Authors: James Brett Case, Samantha Mackin, John M Errico, Zhenlu Chong, Emily A Madden, Bradley Whitener, Barbara Guarino, Michael A Schmid, Kim Rosenthal, Kuishu Ren, Ha V Dang, Gyorgy Snell, Ana Jung, Lindsay Droit, Scott A Handley, Peter J Halfmann, Yoshihiro Kawaoka, James E Crowe, Daved H Fremont, Herbert W Virgin, Yueh-Ming Loo, Mark T Esser, Lisa A Purcell, Davide Corti, Michael S Diamond

Journal: Nat Commun

PubMed ID: 35780162

Doi: 10.1038/s41467-022-31615-7

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High Mobility Group Protein B1 Decreases Surface Localization of PD-1 to Augment T-cell Activation

Authors: Qun Gao, Shumin Wang, Feng Li, Jingyao Lian, Shaoyan Cheng, Dongli Yue, Zhen Zhang, Shasha Liu, Feifei Ren, Daiqun Zhang, Shengdian Wang, Liping Wang, Yi Zhang

Journal: Cancer Immunol Res

PubMed ID: 35580259

Doi: 10.1158/2326-6066.CIR-21-0652

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Structures of the T cell potassium channel Kv13 with immunoglobulin modulators

Authors: Purushotham Selvakumar, Ana I Fernández-Mariño, Nandish Khanra, Changhao He, Alice J Paquette, Bing Wang, Ruiqi Huang, Vaughn V Smider, William J Rice, Kenton J Swartz, Joel R Meyerson

Journal: Nat Commun

PubMed ID: 35788586

Doi: 10.1038/s41467-022-31285-5

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Physical activity and antibody persistence 6 months after the second dose of CoronaVac in immunocompromised patients

Authors: Bruno Gualano, Ítalo Ribeiro Lemes, Rafael Pires da Silva, Ana Jéssica Pinto, Bruna Caruso Mazzolani, Fabiana Infante Smaira, Sofia Mendes Sieczkowska, Nádia Emi Aikawa, Sandra Pasoto, Ana Cristina Medeiros-Ribeiro, Carla Saad, Emily Yuk, Clovis Silva, Paul Swinton, Pedro Curi Hallal, Hamilton Roschel, Eloisa Bonfa

Journal: Scand J Med Sci Sports

PubMed ID: 35844042

Doi: 10.1111/sms.14213

Core cysteine residues in the Plasminogen-Apple-Nematode (PAN) domain are critical for HGF/c-MET signaling

Authors: Debjani Pal , Kuntal De , Carly M Shanks , Kai Feng , Timothy B Yates , Jennifer Morrell-Falvey , Russell B Davidson , Jerry M Parks , Wellington Muchero

Journal: Commun Biol

PubMed ID: 35778602

Doi: 10.1038/s42003-022-03582-8

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Hsp70 inhibits the replication of Fowl Adenovirous serotype 4 by suppressing viral Hexon with the assistance of DnaJC7

Authors: Jie Cao , Shuhui Liu , Meng Liu , Shuaiwen Wang , Zhenwei Bi , Wentao Fan , Zhiyu Shi , Suquan Song , Liping Yan

Journal: J Virol

PubMed ID: 35852354

Doi: 10.1128/jvi.00807-22

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Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker

Authors: Aslan Mansurov , Peyman Hosseinchi, Kevin Chang, Abigail L Lauterbach, Laura T Gray , Aaron T Alpar , Erica Budina , Anna J Slezak , Seounghun Kang, Shijie Cao, Ani Solanki , Suzana Gomes , John-Michael Williford, Melody A Swartz , Juan L Mendoza , Jun Ishihara , Jeffrey A Hubbell

Journal: Nat Biomed Eng

PubMed ID: 35534574

Doi: 10.1038/s41551-022-00888-0

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Identification of nucleoside monophosphates and their epigenetic modifications using an engineered nanopore.

Authors: Yuqin Wang , Shanyu Zhang , Wendong Jia ,Pingping Fan , Liying Wang , Xinyue Li , Jialu Chen , Zhenyuan Cao , Xiaoyu Du , Yao Liu , Kefan Wang , Chengzhen Hu , Jinyue Zhang , Jun Hu , Panke Zhang , Hong-Yuan Chen , Shuo Huang

Journal: Nat Nanotechnol

PubMed ID: 35851382

Doi: 10.1038/s41565-022-01169-2

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Oncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancer

Authors: Qiuman Wang , Xinyue Ma , Huan Wu , Chen Zhao 1, Jingying Chen , Rongrong Li , Shi Yan , Yingwei Li , Qing Zhang , Kun Song , Cunzhong Yuan , Beihua Kong

Journal: Oncoimmunology

PubMed ID: 35800156

Doi: 10.1080/2162402X.2022.2096362 Free PMC article

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Developing and validating SARS-CoV-2 assays for nonhuman primate surveillance

Authors: JoAnn Yee, Amanda Carpenter, Peter Nham, Bryson Halley, Koen K A Van Rompay, Jeffrey Roberts

Journal: J Med Primatol

PubMed ID: 35794847

Doi: 10.1111/jmp.12604

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Correction: High level SARS-CoV-2 nucleocapsid refolding using mild condition for inclusion bodies solubilization: Application of high pressure at pH 90

Authors:

Journal: PLoS ONE

PubMed ID: 35788214

Doi: 10.1371/journal.pone.0271140

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CaMKII Inhibition Attenuates Distinct Gain-of-Function Effects Produced by Mutant Nav16 Channels and Reduces Neuronal Excitability

Authors: Agnes S Zybura, Firoj K Sahoo, Andy Hudmon, Theodore R Cummins

Journal: Cells

PubMed ID: 35805192

Doi: 10.3390/cells11132108

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An Engineered λ Phage Enables Enhanced and Strain-Specific Killing of Enterohemorrhagic Escherichia coli

Authors: Menglu Jin, Jingchao Chen, Xueyang Zhao, Guoru Hu, Hailei Wang, Zhi Liu, Wei-Hua Chen

Journal: Microbiol Spectr

PubMed ID: 35876591

Doi: 10.1128/spectrum.01271-22

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Development and Assessment of Herpes Simplex Virus Type 1 (HSV-1) Amplicon Vectors with Sensory Neuron-Selective Promoters

Authors: Charles Joussain, Olivier Le Coz, Andrey Pichugin, Peggy Marconi, Filip Lim, Mariaconcetta Sicurella, Keith Foster, François Giuliano, Alberto L Epstein, Alejandro Aranda Muñoz

Journal: Int J Mol Sci

PubMed ID: 35955608

Doi: 10.3390/ijms23158474

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Reprogramming of Human B Cells from Secreting IgG to IgM by Genome Editing

Authors: Guigao Lin, Kuo Zhang, Yanxi Han, Rongxue Peng, Jiawei Zhang, Dandan Li, Jinming Li

Journal: CRISPR J

PubMed ID: 35900273

Doi: 10.1089/crispr.2021.0093

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Antitumor efficacy of MUC1-derived variable epitope library treatments in a mouse model of breast cancer

Authors: Josué Odales, Rodolfo Servín-Blanco, Fernando Martínez-Cortés, Jesus Guzman Valle, Allan Noé Domínguez-Romero, Goar Gevorkian, Karen Manoutcharian

Journal: Vaccine

PubMed ID: 35788294

Doi: 10.1016/j.vaccine.2022.06.062

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O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1

Authors: Qiang Zhu, Hong Zhou, Liming Wu, Zhenyuan Lai, Didi Geng, Weiwei Yang, Jie Zhang, Zhiya Fan, Weijie Qin, Yong Wang, Ruhong Zhou, Wen Yi

Journal: Nat Chem Biol

PubMed ID: 35879546

Doi: 10.1038/s41589-022-01085-5

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Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut

Authors: Víctor Taleb, Qinghua Liao, Yoshiki Narimatsu, Ana García-García, Ismael Compañón, Rafael Junqueira Borges, Andrés Manuel González-Ramírez, Francisco Corzana, Henrik Clausen, Carme Rovira, Ramon Hurtado-Guerrero

Journal: Nat Commun

PubMed ID: 35882872

Doi: 10.1038/s41467-022-32021-9

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Phage Particles of Controlled Length and Genome for Targeted Glioblastoma Imaging and Therapeutic Delivery

Authors: Uyanga Tsedev, Ching-Wei Lin, Gaelen T Hess, Jann N Sarkaria, Fred C Lam, Angela M Belcher

Journal: ACS Nano

PubMed ID: 35830573

Doi: 10.1021/acsnano.1c08720

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Impacts of a Zwitterionic Peptide on its Fusion Protein

Authors: Patrick McMullen, Liang Fang, Qi Qiao, Qing Shao, Shaoyi Jiang

Journal: Bioconjug Chem

PubMed ID: 35852436

Doi: 10.1021/acs.bioconjchem.2c00176

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Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis

Authors: Nikola Kenjić, Kathleen M Meneely, Daniel J Wherritt, Melissa C Denler, Timothy A Jackson, Graham R Moran, Audrey L Lamb

Journal: J Am Chem Soc

PubMed ID: 35802469

Doi: 10.1021/jacs.2c03376

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Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice

Authors: Yuning Liu, Hong Xing, Alexis F Ernst, Canna Liu, Christian Maugee, Fumiaki Yokoi, Madepalli Lakshmana, Yuqing Li

Journal: Mol Cell Neurosci

PubMed ID: 35843530

Doi: 10.1016/j.mcn.2022.103756

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Bacteria deplete deoxynucleotides to defend against bacteriophage infection

Authors: Nitzan Tal, Adi Millman, Avigail Stokar-Avihail, Taya Fedorenko, Azita Leavitt, Sarah Melamed, Erez Yirmiya, Carmel Avraham, Alexander Brandis, Tevie Mehlman, Gil Amitai, Rotem Sorek

Journal: Nat Microbiol

PubMed ID: 35817891

Doi: 10.1038/s41564-022-01158-0

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Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge

Authors: Shanna S Leventhal, Kimberly Meade-White, Deepashri Rao, Elaine Haddock, Jacqueline Leung, Dana Scott, Jacob Archer, Samantha Randall, Jesse H Erasmus, Heinz Feldmann, David W Hawman

Journal: EBioMedicine

PubMed ID: 35907368

Doi: 10.1016/j.ebiom.2022.104188

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Tumor-Localized Administration of α-GalCer to Recruit Invariant Natural Killer T Cells and Enhance Their Antitumor Activity against Solid Tumors

Authors: Yan-Ruide Li, Yang Zhou, Matthew Wilson, Adam Kramer, Ryan Hon, Yichen Zhu, Ying Fang, Lili Yang

Journal: Int J Mol Sci

PubMed ID: 35886891

Doi: 10.3390/ijms23147547

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miR-301b-5p and its target gene nfatc2ip regulate inflammatory responses in the liver of rainbow trout (Oncorhynchus mykiss) under high temperature stress

Authors: Tianqing Huang, Wei Gu, Enhui Liu, Bingqian Wang, Gaochao Wang, Fulin Dong, Fuyuan Guo, Wenlong Jiao, Yanchun Sun, Xiance Wang, Shanwei Li, Gefeng Xu

Journal: Ecotoxicol Environ Saf

PubMed ID: 35901591

Doi: 10.1016/j.ecoenv.2022.113915

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An immunodetection assay developed using cobra cytotoxin-specific antibodies: Potential diagnostics for cobra envenoming

Authors: Hui Ling Ong, Choo Hock Tan, Louisa Pernee Lee, Sook Mei Khor, Kae Yi Tan

Journal: Toxicon

PubMed ID: 35868411

Doi: 10.1016/j.toxicon.2022.07.010

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A Single Dose of Anti-HBsAg Antibody-Encoding mRNA-LNPs Suppressed HBsAg Expression: a Potential Cure of Chronic Hepatitis B Virus Infection

Authors: Binfan Chen, Yuchen Chen, Jian Li, Chunyu Wang, Wenping Song, Yumei Wen, Jinzhong Lin, Yanling Wu, Tianlei Ying

Journal: MBio

PubMed ID: 35862767

Doi: 10.1128/mbio.01612-22

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Phage defence by deaminase-mediated depletion of deoxynucleotides in bacteria

Authors: Brian Y Hsueh, Geoffrey B Severin, Clinton A Elg, Evan J Waldron, Abhiruchi Kant, Alex J Wessel, John A Dover, Christopher R Rhoades, Benjamin J Ridenhour, Kristin N Parent, Matthew B Neiditch, Janani Ravi, Eva M Top, Christopher M Waters

Journal: Nat Microbiol

PubMed ID: 35817890

Doi: 10.1038/s41564-022-01162-4

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Paraneoplastic Pemphigus Autoantibodies Against C-terminus of Desmoplakin Induced Acantholysis and

Authors: Xue Wang, Rui Wang, Dingfang Bu, Leyi Wang, Yuexin Zhang, Yuan Chang, Chenyang Zhang, Xixue Chen, Xuejun Zhu, Zhi Liu, Mingyue Wang

Journal: Front Immunol

PubMed ID: 35911677

Doi: 10.3389/fimmu.2022.886226

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In situ architecture of the lipid transport protein VPS13C at ER-lysosome membrane contacts

Authors: Shujun Cai, Yumei Wu, Andrés Guillén-Samander, William Hancock-Cerutti, Jun Liu, Pietro De Camilli

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35858323

Doi: 10.1073/pnas.2203769119

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Development and applications of a TaqMan based quantitative real-time PCR for the rapid detection of Pigeon circovirus (PiCV)

Authors: Babu K Nath, Shubhagata Das, Tridip Das, Jade K Forwood, Shane R Raidal

Journal: J Virol Methods

PubMed ID: 35870671

Doi: 10.1016/j.jviromet.2022.114588

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Protective effects of small heat shock proteins in Daphnia magna against heavy metal exposure

Authors: Muyi Li, Ting Tang, Fengyu Yuan, Yuming Zhang, Fengchao Li, Fengsong Liu

Journal: Sci Total Environ

PubMed ID: 35907523

Doi: 10.1016/j.scitotenv.2022.157565

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The transient expression of recombinant proteins in plant cell packs facilitates stable isotope labelling for NMR spectroscopy

Authors: Patrick Opdensteinen, Laura E Sperl, Mariam Mohamadi, Nicole Kündgen-Redding, Franz Hagn, Johannes Felix Buyel

Journal: Plant Biotechnol J

PubMed ID: 35702941

Doi: 10.1111/pbi.13873

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SARS-CoV-2 Omicron escapes mRNA vaccine booster-induced antibody neutralisation in patients with autoimmune rheumatic diseases: an observational cohort study

Authors: Woo-Joong Kim, Seong-Ho Choi, Ji Young Park, Jung Soo Song, Jin-Won Chung, Sang Tae Choi

Journal: Ann Rheum Dis

PubMed ID: 35878999

Doi: 10.1136/ard-2022-222689

Screening circular RNAs with functional potential using the RfxCas13d/BSJ-gRNA system

Authors: Siqi Li, Hao Wu, Ling-Ling Chen

Journal: Nat Protoc

PubMed ID: 35831613

Doi: 10.1038/s41596-022-00715-5

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Cholesterol Deprivation Drives DHEA Biosynthesis in Human Adrenals

Authors: Emanuele Pignatti, Emre Murat Altinkilic, Konstantin Bräutigam, Michael Grössl, Aurel Perren, Mihaela Zavolan, Christa E Flück

Journal: Endocrinology

PubMed ID: 35583599

Doi: 10.1210/endocr/bqac076

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The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE mice

Authors: Yishi Shen, Hong-Mei Gu, Lei Zhai, Binxiang Wang, Shucun Qin, Da-Wei Zhang

Journal: Biochim Biophys Acta Mol Cell Biol Lipids

PubMed ID: 35803528

Doi: 10.1016/j.bbalip.2022.159196

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SARS-CoV-2 Epitopes following Infection and Vaccination Overlap Known Neutralizing Antibody Sites

Authors: Li Yang, Te Liang, Lane M Pierson, Hongye Wang, Jesse K Fletcher, Shu Wang, Duran Bao, Lili Zhang, Zhen Huang, Wenshu Zheng, Xiaomei Zhang, Heewon Park, Yuwen Li, James E Robinson, Amy K Feehan, Christopher J Lyon, Jing Cao, Lisa A Morici, Chenzhong Li, Chad J Roy, Xiaobo Yu, Tony Hu

Journal: Research (Wash D C)

PubMed ID: 35928300

Doi: 10.34133/2022/9769803

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RG203KR Mutations in SARS-CoV-2 Nucleocapsid: Assessing the Impact Using a Virus-Like Particle Model System

Authors: Harsha Raheja, Soma Das, Anindita Banerjee, Dikshaya P, Deepika C, Debanjan Mukhopadhyay, Subbaraya G Ramachandra, Saumitra Das

Journal: Microbiol Spectr

PubMed ID: 35862952

Doi: 10.1128/spectrum.00781-22

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Development of an in-house quantitative ELISA for the evaluation of different Covid-19 vaccines in humans

Authors: Mariem Gdoura, Fatma Ben Ghaloum, Meriem Ben Hamida, Wafa Chamsa, Henda Triki, Chokri Bahloul

Journal: Sci Rep

PubMed ID: 35788676

Doi: 10.1038/s41598-022-15378-1

The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency Pathway

Authors: Lindsay C Sidak-Loftis, Kristin L Rosche, Natasha Pence, Jessica K Ujczo, Joanna Hurtado, Elis A Fisk, Alan G Goodman, Susan M Noh, John W Peters, Dana K Shaw

Journal: MBio

PubMed ID: 35862781

Doi: 10.1128/mbio.00703-22

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In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus

Authors: Linda B Oyama, Hamza Olleik, Ana Carolina Nery Teixeira, Matheus M Guidini, James A Pickup, Brandon Yeo Pei Hui, Nicolas Vidal, Alan R Cookson, Hannah Vallin, Toby Wilkinson, Denise M S Bazzolli, Jennifer Richards, Mandy Wootton, Ralf Mikut, Kai Hilpert, Marc Maresca, Josette Perrier, Matthias Hess, Hilario C Mantovani, Narcis Fernandez-Fuentes, Christopher J Creevey, Sharon A Huws

Journal: NPJ Biofilms Microbiomes

PubMed ID: 35835775

Doi: 10.1038/s41522-022-00320-0

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Development of Melioidosis Subunit Vaccines Using an Enzymatically Inactive Burkholderia pseudomallei AhpC

Authors: Lindsey K Schmidt, Caitlyn E Orne, Teresa L Shaffer, Shane M Wilson, Nittaya Khakhum, Alfredo G Torres, Paul J Brett, Mary N Burtnick

Journal: Infect Immun

PubMed ID: 35862715

Doi: 10.1128/iai.00222-22

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Sequence grammar underlying the unfolding and phase separation of globular proteins

Authors: Kiersten M Ruff, Yoon Hee Choi, Dezerae Cox, Angelique R Ormsby, Yoochan Myung, David B Ascher, Sheena E Radford, Rohit V Pappu, Danny M Hatters

Journal: Mol Cell

PubMed ID: 35853451

Doi: 10.1016/j.molcel.2022.06.024

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Ancestrally Reconstructed von Willebrand Factor Reveals Evidence for Trench Warfare Coevolution between Opossums and Pit Vipers

Authors: Danielle H Drabeck, Alexandra Rucavado, Erika Hingst-Zaher, Antony Dean, Sharon A Jansa

Journal: Mol Biol Evol

PubMed ID: 35723968

Doi: 10.1093/molbev/msac140

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Efficient multiplex CRISPR/Cpf1 (Cas12a) genome editing system in Aspergillus aculeatus TBRC 277

Authors: Dede Abdulrachman, Verawat Champreda, Lily Eurwilaichitr, Duriya Chantasingh, Kusol Pootanakit

Journal: J Biotechnol

PubMed ID: 35788357

Doi: 10.1016/j.jbiotec.2022.06.011

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Calcium responses to external mechanical stimuli in the multicellular stage of Dictyostelium discoideum

Authors: Hidenori Hashimura, Yusuke V Morimoto, Yusei Hirayama, Masahiro Ueda

Journal: Sci Rep

PubMed ID: 35859163

Doi: 10.1038/s41598-022-16774-3

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Conformational landscape of the yeast SAGA complex as revealed by cryo-EM

Authors: Diana Vasyliuk, Joeseph Felt, Ellen D Zhong, Bonnie Berger, Joseph H Davis, Calvin K Yip

Journal: Sci Rep

PubMed ID: 35853968

Doi: 10.1038/s41598-022-16391-0

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Rhesus rotavirus receptor-binding site affects high mobility group box 1 release, altering the pathogenesis of experimental biliary atresia

Authors: Sujit K Mohanty, Bryan Donnelly, Haley Temple, Sarah Mowery, Holly M Poling, Jaroslaw Meller, Astha Malik, Monica McNeal, Greg Tiao

Journal: Hepatol Commun

PubMed ID: 35866580

Doi: 10.1002/hep4.2024

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Development and characterization of an inducible assay system to measure Zika virus capsid interactions

Authors: Jieshi Yu, Chen Huang, Zhao Wang, Radhey S Kaushik, Zizhang Sheng, Feng Li, Dan Wang

Journal: J Med Virol

PubMed ID: 35822280

Doi: 10.1002/jmv.27991

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Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos

Authors: Fanye Meng, Chenxi Xu, Kwang-Su Park, H Ümit Kaniskan, Gang Greg Wang, Jian Jin

Journal: J Med Chem

PubMed ID: 35895319

Doi: 10.1021/acs.jmedchem.2c00807

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The Patterning and Proportion of Charged Residues in the Arginine-Rich Mixed-Charge Domain Determine the Membrane-Less Organelle Targeted by the Protein

Authors: Tamami Miyagi, Rio Yamazaki, Koji Ueda, Satoshi Narumi, Yuhei Hayamizu, Hiroshi Uji-I, Masahiko Kuroda, Kohsuke Kanekura

Journal: Int J Mol Sci

PubMed ID: 35887012

Doi: 10.3390/ijms23147658

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Silencing the enhancer of zeste homologue 2, E, represses axon regeneration of dorsal root ganglion neuronszh 2

Authors: Ting-Ting Guo, Ying Zhao, Wei-Xiao Huang, Tao Zhang, Li-Li Zhao, Xiao-Song Gu, Song-Lin Zhou

Journal: Neural Regen Res

PubMed ID: 34916437

Doi: 10.4103/1673-5374.330623

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NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections

Authors: Philippe Rascle, Cyril Planchais, Béatrice Jacquelin, Marie Lazzerini, Vanessa Contreras, Caroline Passaes, Asier Saez-Cirion, Hugo Mouquet, Nicolas Huot, Michaela Müller-Trutwin

Journal: Commun Biol

PubMed ID: 35798936

Doi: 10.1038/s42003-022-03619-y

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Peptide-siRNA nanoparticles targeting NF-κB p50 mitigate experimental abdominal aortic aneurysm progression and rupture

Authors: Huimin Yan, Ying Hu, Antonina Akk, Samuel A Wickline, Hua Pan, Christine T N Pham

Journal: Biomater Adv

PubMed ID: 35891603

Doi: 10.1016/j.bioadv.2022.213009

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Apela gene therapy alleviates pulmonary hypertension in rats

Authors: Yuexin Hu, Liangli Jin, Yang Pan, Jue Zou, Zhi Wang

Journal: FASEB J

PubMed ID: 35747913

Doi: 10.1096/fj.202200266R

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Construction of a Novel Clinical Stage-Related Gene Signature for Predicting Outcome and Immune Response in Hepatocellular Carcinoma

Authors: Liu Yang, Long-Fei Zeng, Guo-Qing Hong, Qing Luo, Xing Lai

Journal: J Immunol Res

PubMed ID: 35865652

Doi: 10.1155/2022/6535009

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Structural, functional, and immunogenicity implications of F9 gene recoding

Authors: Upendra K Katneni, Aikaterini Alexaki, Ryan C Hunt, Nobuko Hamasaki-Katagiri, Gaya K Hettiarachchi, Jacob M Kames, Joseph R McGill, David D Holcomb, John C Athey, Brian Lin, Leonid A Parunov, Tal Kafri, Qi Lu, Robert Peters, Mikhail V Ovanesov, Darón I Freedberg, Haim Bar, Anton A Komar, Zuben E Sauna, Chava Kimchi-Sarfaty

Journal: Blood Adv

PubMed ID: 35413099

Doi: 10.1182/bloodadvances.2022007094

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