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oligosaccharides increase serotonin in the brain and ameliorate depression promoting 5-hydroxytryptophan production in the gut microbiota

Authors: Zheng-Wei Zhang, Chun-Sheng Gao, Heng Zhang, Jian Yang, Ya-Ping Wang, Li-Bin Pan, Hang Yu, Chi-Yu He, Hai-Bin Luo, Zhen-Xiong Zhao, Xin-Bo Zhou, Yu-Li Wang, Jie Fu, Pei Han, Yu-Hui Dong, Gang Wang, Song Li, Yan Wang, Jian-Dong Jiang, Wu Zhong

Journal: Acta Pharm Sin B

PubMed ID: 35967282

Doi: 10.1016/j.apsb.2022.02.032

Products & Services: PCR Cloning and Subcloning

Activation mechanism of the class D fungal GPCR dimer Ste2

Authors: Vaithish Velazhahan, Ning Ma, Nagarajan Vaidehi, Christopher G Tate

Journal: Nature

PubMed ID: 35296853

Doi: 10.1038/s41586-022-04498-3

Products & Services: Proteins, Expression, Isolation and Analysis

Nephronectin-integrin α8 signaling is required for proper migration of periocular neural crest cells during chick corneal development

Authors: Justin Ma, Lian Bi, James Spurlin, Peter Lwigale

Journal: Elife

PubMed ID: 35238772

Doi: 10.7554/eLife.74307

Products & Services: PCR Cloning and Subcloning

Antibodies Targeting KSHV gH/gL Reveal Distinct Neutralization Mechanisms

Authors: Thomas Fricke, Anna K Großkopf, Armin Ensser, Marija Backovic, Alexander S Hahn

Journal: Viruses

PubMed ID: 35336948

Doi: 10.3390/v14030541

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Directed evolution of adeno-associated virus 5 capsid enables specific liver tropism

Authors: Yuqiu Wang, Chen Yang, Hanyang Hu, Chen Chen, Mengdi Yan, Feixiang Ling, Kathy Cheng Wang, Xintao Wang, Zhe Deng, Xinyue Zhou, Feixu Zhang, Sen Lin, Zengmin Du, Kai Zhao, Xiao Xiao

Journal: Mol Ther Nucleic Acids

PubMed ID: 35474733

Doi: 10.1016/j.omtn.2022.03.017

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Specificity and Reactivity of Serine/Threonine Kinases PknG and PknB

Authors: Osvaldo Burastero, Marisol Cabrera, Elias D Lopez, Lucas A Defelipe, Juan Pablo Arcon, Rosario Durán, Marcelo A Marti, Adrian G Turjanski

Journal: J Chem Inf Model

PubMed ID: 35319884

Doi: 10.1021/acs.jcim.1c01358

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A novel silk fibroin protein-based fusion system for enhancing the expression of nanobodies in Escherichia coli

Authors: Jianli Yu, Yang Guo, Yi Gu, Xiying Fan, Fei Li, Haipeng Song, Rui Nian, Wenshuai Liu

Journal: Appl Microbiol Biotechnol

PubMed ID: 35243528

Doi: 10.1007/s00253-022-11857-7

Products & Services: Proteins, Expression, Isolation and Analysis

Treatment Regimens for Transplant-Ineligible Patients With Newly Diagnosed Multiple Myeloma: A Systematic Literature Review and Network Meta-analysis

Authors: Thierry Facon, Jesús San-Miguel, Meletios A Dimopoulos, Maria-Victoria Mateos, Michele Cavo, Sophie van Beekhuizen, Zijiao Yuan, João Mendes, Annette Lam, Jianming He, Eric Ammann, Shaji Kumar

Journal: Adv Ther

PubMed ID: 35246820

Doi: 10.1007/s12325-022-02083-8

Products & Services: Gene Synthesis

Molnupiravir and Nirmatrelvir-Ritonavir: Oral COVID Antiviral Drugs

Authors: Louis D Saravolatz, Shawn Depcinski, Mamta Sharma

Journal: Clin Infect Dis

PubMed ID: 35245942

Doi: 10.1093/cid/ciac180

Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane Fusion

Authors: Chia-Jung Li, Tai-Ling Chao, Ting-Yu Chang, Chia-Chun Hsiao, De-Chao Lu, Yi-Wei Chiang, Guan-Chun Lai, Ya-Min Tsai, Jun-Tung Fang, Siman Ieong, Jann-Tay Wang, Sui-Yuan Chang, Shih-Chung Chang

Journal: Microbiol Spectr

PubMed ID: 35293796

Doi: 10.1128/spectrum.01814-21

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Characterization of UDP-glycosyltransferase family members reveals how major flavonoid glycoside accumulates in the roots of Scutellaria baicalensis

Authors: Tianlin Pei, Mengxiao Yan, Tian Li, Xiaoqiang Li, Yijia Yin, Mengying Cui, Yumin Fang, Jie Liu, Yu Kong, Ping Xu, Qing Zhao

Journal: BMC Genomics

PubMed ID: 35232374

Doi: 10.1186/s12864-022-08391-1

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Two independent cis-acting elements are required for the guard cell-specific expression of SCAP1, which is essential for late stomatal development

Authors: Kosuke Moriwaki, Shuichi Yanagisawa, Koh Iba, Juntaro Negi

Journal: Plant J

PubMed ID: 35061307

Doi: 10.1111/tpj.15679

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Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model

Authors: Julie A Zorn, Matthew L Wheeler, Ralston M Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y-C Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop

Journal: Sci Rep

PubMed ID: 35241687

Doi: 10.1038/s41598-022-06953-7

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Theileria equi RAP-1a and RAP-1b proteins contain immunoreactive epitopes and are suitable candidates for vaccine and diagnostics development

Authors: Cynthia K Onzere, Lindsay M Fry, Richard P Bishop, Marta Da Silva, Sally A Madsen-Bouterse, Reginaldo G Bastos, Donald P Knowles, Carlos E Suarez

Journal: Int J Parasitol

PubMed ID: 35318949

Doi: 10.1016/j.ijpara.2022.01.004

Products & Services: Recombinant Antibody Expression

Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF melanoma

Authors: Lorey K Smith, Tiffany Parmenter, Margarete Kleinschmidt, Eric P Kusnadi, Jian Kang, Claire A Martin, Peter Lau, Riyaben Patel, Julie Lorent, David Papadopoli, Anna Trigos, Teresa Ward, Aparna D Rao, Emily J Lelliott, Karen E Sheppard, David Goode, Rodney J Hicks, Tony Tiganis, Kaylene J Simpson, Ola Larsson, Benjamin Blythe, Carleen Cullinane, Vihandha O Wickramasinghe, Richard B Pearson, Grant A McArthur

Journal: Nat Commun

PubMed ID: 35232962

Doi: 10.1038/s41467-022-28705-x

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Development of a p72 trimer-based colloidal gold strip for detection of antibodies against African swine fever virus

Authors: Rui Geng, Yaning Sun, Rui Li, Jifei Yang, Hongfang Ma, Zixuan Qiao, Qingxia Lu, Songlin Qiao, Gaiping Zhang

Journal: Appl Microbiol Biotechnol

PubMed ID: 35291024

Doi: 10.1007/s00253-022-11851-z

Products & Services: Proteins, Expression, Isolation and Analysis

Baohuoside I Inhibits Tumor Angiogenesis in Multiple Myeloma the Peroxisome Proliferator-Activated Receptor γ/Vascular Endothelial Growth Factor Signaling Pathway

Authors: Ying Chen, Lina Zhang, Xiaoyan Zang, Xuxing Shen, Jianyong Li, Lijuan Chen

Journal: Front Pharmacol

PubMed ID: 35341213

Doi: 10.3389/fphar.2022.822082

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Development and Validation of a Competitive ELISA Based on Bovine Monoclonal Antibodies for the Detection of Neutralizing Antibodies against Foot-and-Mouth Disease Virus Serotype A

Authors: Yimei Cao, Kun Li, Xiangchuan Xing, Guoqiang Zhu, Yuanfang Fu, Huifang Bao, Xingwen Bai, Pu Sun, Pinghua Li, Jing Zhang, Xueqing Ma, Jian Wang, Zhixun Zhao, Dong Li, Zaixin Liu, Zengjun Lu

Journal: J Clin Microbiol

PubMed ID: 35254106

Doi: 10.1128/jcm.02142-21

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Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy

Authors: Juan Qin, Jingfeng Zhang, Lianyun Lin, Omid Haji-Ghassemi, Zhi Lin, Kenneth J Woycechowsky, Filip Van Petegem, Yan Zhang, Zhiguang Yuchi

Journal: Elife

PubMed ID: 35297759

Doi: 10.7554/eLife.75346

Products & Services: Mutant Libraries

ClpX/P-Dependent Degradation of Novel Substrates in Streptococcus mutans

Authors: Vivek Gurung, Indranil Biswas

Journal: J Bacteriol

PubMed ID: 35343773

Doi: 10.1128/jb.00594-21

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Restriction of viral gene expression and replication prevents immortalization of human keratinocytes by a beta-human papillomavirus

Authors: Tina M Rehm, Elke Straub, Thomas Iftner, Frank Stubenrauch

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35254896

Doi: 10.1073/pnas.2118930119

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Predictable NHEJ Insertion and Assessment of HDR Editing Strategies in Plants

Authors: Kutubuddin A Molla, Justin Shih, Matthew S Wheatley, Yinong Yang

Journal: Front Genome Ed

PubMed ID: 35481279

Doi: 10.3389/fgeed.2022.825236

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COVID-19 Convalescent Plasma and Clinical Trials: Understanding Conflicting Outcomes

Authors: Daniele Focosi, Massimo Franchini, Liise-Anne Pirofski, Thierry Burnouf, Nigel Paneth, Michael J Joyner, Arturo Casadevall

Journal: Clin Microbiol Rev

PubMed ID: 35262370

Doi: 10.1128/cmr.00200-21

Products & Services: Proteins, Expression, Isolation and Analysis

Engineering Saccharomyces cerevisiae for the production and secretion of Affibody molecules

Authors: Veronica Gast, Anna Sandegren, Finn Dunås, Siri Ekblad, Rezan Güler, Staffan Thorén, Marta Tous Mohedano, Mikael Molin, Martin K M Engqvist, Verena Siewers

Journal: Microb Cell Fact

PubMed ID: 35264156

Doi: 10.1186/s12934-022-01761-0

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Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling

Authors: Kelly J Culhane, Tejas M Gupte, Indrani Madhugiri, Chetan J Gadgil, Sivaraj Sivaramakrishnan

Journal: Nat Commun

PubMed ID: 35260563

Doi: 10.1038/s41467-022-28789-5

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MiR-183-5p overexpression in bone mesenchymal stem cell-derived exosomes protects against myocardial ischemia/reperfusion injury by targeting FOXO1

Authors: Shuai Mao, Jing Zhao, Zhao-Juan Zhang, Qin Zhao

Journal: Immunobiology

PubMed ID: 35314383

Doi: 10.1016/j.imbio.2022.152204

Products & Services: Recombinant Proteins

Self-amplifying mRNA SARS-CoV-2 vaccines raise cross-reactive immune response to variants and prevent infection in animal models

Authors: Giuseppe Palladino, Cheng Chang, Changkeun Lee, Nedzad Music, Ivna De Souza, Jonathan Nolasco, Samuel Amoah, Pirada Suphaphiphat, Gillis R Otten, Ethan C Settembre, Yingxia Wen

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35345593

Doi: 10.1016/j.omtm.2022.03.013

Products & Services: Mammalian Expression

Inactivated SARS-CoV-2 vaccine in primary Sjögren's syndrome: humoral response, safety, and effects on disease activity

Authors: Sandra Gofinet Pasoto, Ari Stiel Radu Halpern, Lissiane Karine Noronha Guedes, Ana Cristina Medeiros Ribeiro, Emily Neves Figueiredo Yuki, Carla Gonçalves Schahin Saad, Clovis Artur Almeida da Silva, Léonard de Vinci Kanda Kupa, Lorena Elizabeth Betancourt Villamarín, Victor Adriano de Oliveira Martins, Carolina Campagnoli Machado Freire Martins, Giordano Bruno Henriques Deveza, Elaine Pires Leon, Cleonice Bueno, Tatiana Nascimento Pedrosa, Roseli Eliana Beseggio Santos, Renata Soares, Nádia Emi Aikawa, Eloisa Bonfa

Journal: Clin Rheumatol

PubMed ID: 35306594

Doi: 10.1007/s10067-022-06134-x

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METTL14-mediated N6-methyladenosine modification of Pten mRNA inhibits tumour progression in clear-cell renal cell carcinoma

Authors: Lili Zhang, Xiaofang Luo, Sen Qiao

Journal: Br J Cancer

PubMed ID: 35249103

Doi: 10.1038/s41416-022-01757-y

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Modular engineering of coculture for efficient production of resveratrol from glucose and arabinose mixture

Authors: Jia Li, Zetian Qiu, Guang-Rong Zhao

Journal: Synth Syst Biotechnol

PubMed ID: 35330959

Doi: 10.1016/j.synbio.2022.03.001

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Mobility of FLOWERING LOCUS T protein as a systemic signal in trifoliate orange and its low accumulation in grafted juvenile scions

Authors: Yan-Mei Wu, Yu-Jiao Ma, Min Wang, Huan Zhou, Zhi-Meng Gan, Ren-Fang Zeng, Li-Xia Ye, Jing-Jing Zhou, Jin-Zhi Zhang, Chun-Gen Hu

Journal: Hortic Res

PubMed ID: 35702366

Doi: 10.1093/hr/uhac056

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Expression in Wilms Tumor Is Regulated by Promoter Mutation or Hypermethylation, WT1, and N-MYC

Authors: Carolyn M Jablonowski, Hyea Jin Gil, Emilia M Pinto, Prahalathan Pichavaram, Andrew M Fleming, Michael R Clay, Dongli Hu, Christopher L Morton, Shondra M Pruett-Miller, Baranda S Hansen, Xiang Chen, Karissa M Dieseldorff Jones, Yanling Liu, Xiaotu Ma, Jun Yang, Andrew M Davidoff, Gerard P Zambetti, Andrew J Murphy

Journal: Cancers (Basel)

PubMed ID: 35406427

Doi: 10.3390/cancers14071655

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Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus

Authors: Douglas N Brawley, David B Sauer, Jianping Li, Xuhui Zheng, Akiko Koide, Ganesh S Jedhe, Tiffany Suwatthee, Jinmei Song, Zheng Liu, Paramjit S Arora, Shohei Koide, Victor J Torres, Da-Neng Wang, Nathaniel J Traaseth

Journal: Nat Chem Biol

PubMed ID: 35361990

Doi: 10.1038/s41589-022-00994-9

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Peptide mediated, enhanced toxicity of a bacterial pesticidal protein against southern green stink bug

Authors: Rahul Banerjee, Biviana Flores-Escobar, Nanasaheb P Chougule, Pablo Emiliano Cantón, Razvan Dumitru, Bryony C Bonning

Journal: Microb Biotechnol

PubMed ID: 35315236

Doi: 10.1111/1751-7915.14030

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Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concern

Authors: Jeroen Pollet, Ulrich Strych, Wen-Hsiang Chen, Leroy Versteeg, Brian Keegan, Bin Zhan, Junfei Wei, Zhuyun Liu, Jungsoon Lee, Rakhi Kundu, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar, Syamala Rani Thimmiraju, Brianna Lopez, Portia M Gillespie, Shannon Ronca, Jason T Kimata, Martin Reers, Vikram Paradkar, Peter Hotez, Maria Elena Bottazzi

Journal: biorxiv

PubMed ID: 34268512

Doi: 10.1101/2021.07.06.451353

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Glutathione binding to the plant Atm3 transporter and implications for the conformational coupling of ABC transporters

Authors: Chengcheng Fan, Douglas C Rees

Journal: Elife

PubMed ID: 35333177

Doi: 10.7554/eLife.76140

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UBR4/POE facilitates secretory trafficking to maintain circadian clock synchrony

Authors: Sara Hegazi, Arthur H Cheng, Joshua J Krupp, Takafumi Tasaki, Jiashu Liu, Daniel A Szulc, Harrod H Ling, Julian Rios Garcia, Shavanie Seecharran, Tayebeh Basiri, Mehdi Amiri, Zobia Anwar, Safa Ahmad, Kamar Nayal, Nahum Sonenberg, Bao-Hua Liu, Hai-Ling Margaret Cheng, Joel D Levine, Hai-Ying Mary Cheng

Journal: Nat Commun

PubMed ID: 35332162

Doi: 10.1038/s41467-022-29244-1

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A "spindle and thread" mechanism unblocks p53 translation by modulating N-terminal disorder

Authors: Margit Kaldmäe, Thibault Vosselman, Xueying Zhong, Dilraj Lama, Gefei Chen, Mihkel Saluri, Nina Kronqvist, Jia Wei Siau, Aik Seng Ng, Farid J Ghadessy, Pierre Sabatier, Borivoj Vojtesek, Médoune Sarr, Cagla Sahin, Nicklas Österlund, Leopold L Ilag, Venla A Väänänen, Saikiran Sedimbi, Marie Arsenian-Henriksson, Roman A Zubarev, Lennart Nilsson, Philip J B Koeck, Anna Rising, Axel Abelein, Nicolas Fritz, Jan Johansson, David P Lane, Michael Landreh

Journal: Structure

PubMed ID: 35290795

Doi: 10.1016/j.str.2022.02.013

Products & Services: Proteins, Expression, Isolation and Analysis

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

Authors: Cheng Li, Wuqiang Zhan, Zhenlin Yang, Chao Tu, Gaowei Hu, Xiang Zhang, Wenping Song, Shujuan Du, Yuanfei Zhu, Keke Huang, Yu Kong, Meng Zhang, Qiyu Mao, Xiaodan Gu, Yi Zhang, Youhua Xie, Qiang Deng, Yuanlin Song, Zhenguo Chen, Lu Lu, Shibo Jiang, Yanling Wu, Lei Sun, Tianlei Ying

Journal: Cell

PubMed ID: 35344711

Doi: 10.1016/j.cell.2022.03.009

Products & Services: PCR Cloning and Subcloning

Ramifications of the HLA-I Allelic Reactivity of Anti-HLA-E*01:01 and Anti-HLA-E*01:03 Heavy Chain Monoclonal Antibodies in Comparison with Anti-HLA-I IgG Reactivity in Non-Alloimmunized Males, Melanoma-Vaccine Recipients, and End-Stage Renal Disease Patients

Authors: Mepur H Ravindranath, Narendranath M Ravindranath, Fatiha El Hilali, Senthamil R Selvan, Edward J Filippone

Journal: Antibodies (Basel)

PubMed ID: 35323192

Doi: 10.3390/antib11010018

Products & Services: Proteins, Expression, Isolation and Analysis

Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY

Authors: Ninako Kimura, Kanako Saito, Takashi Niwa, Masato Yamakawa, Shota Igaue, Junko Ohkanda, Takamitsu Hosoya, Isao Kii

Journal: Protein Expr Purif

PubMed ID: 35307559

Doi: 10.1016/j.pep.2022.106089

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Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/ IRF3-mediated IFN-β production

Authors: Jin Zhao, Jiaoshan Chen, Congcong Wang, Yajie Liu, Minchao Li, Yanjun Li, Ruiting Li, Zirong Han, Junjian Wang, Ling Chen, Yuelong Shu, Genhong Cheng, Caijun Sun

Journal: PLoS Pathog

PubMed ID: 35235615

Doi: 10.1371/journal.ppat.1010366

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Insight into Cellular Uptake and Transcytosis of Peptide Nanoparticles in Cells and Isolated Midgut

Authors: Erin McGraw, Jonathan D Roberts, Nitish Kunte, Matthew Westerfield, Xavier Streety, David Held, L Adriana Avila

Journal: ACS Omega

PubMed ID: 35415340

Doi: 10.1021/acsomega.1c06638

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Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations

Authors: Zheng Fang Yang, Pankaj Panwar, Ciaran R McFarlane, Wietske E Tuinte, Marta Campiglio, Filip Van Petegem

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35238659

Doi: 10.1073/pnas.2120416119

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Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities

Authors: Suhail Khoja, Jenna Lambert, Matthew Nitzahn, Adam Eliav, YuChen Zhang, Mikayla Tamboline, Colleen T Le, Eram Nasser, Yunfeng Li, Puja Patel, Irina Zhuravka, Lindsay M Lueptow, Ilona Tkachyova, Shili Xu, Itzhak Nissim, Andreas Schulze, Gerald S Lipshutz

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35505663

Doi: 10.1016/j.omtm.2022.03.015

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The interaction of dengue virus capsid protein with negatively charged interfaces drives the in vitro assembly of nucleocapsid-like particles

Authors: Nathane C Mebus-Antunes, Wellington S Ferreira, Glauce M Barbosa, Thais C Neves-Martins, Gilberto Weissmuller, Fabio C L Almeida, Andrea T Da Poian

Journal: PLoS ONE

PubMed ID: 35231063

Doi: 10.1371/journal.pone.0264643

Products & Services: Proteins, Expression, Isolation and Analysis

PACER: a novel 3D plant cell wall model for the analysis of non-catalytic and enzymatic responses

Authors: Mareike Monschein, Edita Jurak, Tanja Paasela, Taru Koitto, Vera Lambauer, Mirko Pavicic, Thomas Enjalbert, Claire Dumon, Emma R Master

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 35296345

Doi: 10.1186/s13068-022-02128-8

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Large-scale design and refinement of stable proteins using sequence-only models

Authors: Jedediah M Singer, Scott Novotney, Devin Strickland, Hugh K Haddox, Nicholas Leiby, Gabriel J Rocklin, Cameron M Chow, Anindya Roy, Asim K Bera, Francis C Motta, Longxing Cao, Eva-Maria Strauch, Tamuka M Chidyausiku, Alex Ford, Ethan Ho, Alexander Zaitzeff, Craig O Mackenzie, Hamed Eramian, Frank DiMaio, Gevorg Grigoryan, Matthew Vaughn, Lance J Stewart, David Baker, Eric Klavins

Journal: PLoS ONE

PubMed ID: 35286324

Doi: 10.1371/journal.pone.0265020

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SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes

Authors: LaNisha L Patterson, Thangam Sudha Velayutham, Caitlan D Byerly, Duc Cuong Bui, Jignesh Patel, Veljko Veljkovic, Slobodan Paessler, Jere W McBride

Journal: MBio

PubMed ID: 35357214

Doi: 10.1128/mbio.00076-22

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Structural Basis for Human Receptor Recognition by SARS-CoV-2 Omicron Variant BA1

Authors: Qibin Geng, Ke Shi, Gang Ye, Wei Zhang, Hideki Aihara, Fang Li

Journal: J Virol

PubMed ID: 35343765

Doi: 10.1128/jvi.00249-22

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Mouse Adenovirus Type 1 E4orf6 Induces PKR Degradation

Authors: Berto Tejera-Hernández, Danielle E Goodman, Juan M Nevarez, Katherine R Spindler

Journal: J Virol

PubMed ID: 35285681

Doi: 10.1128/jvi.02063-21

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CRISPR/Cas9-Based Mutagenesis of Histone H31 in Spinal Dynorphinergic Neurons Attenuates Thermal Sensitivity in Mice

Authors: Zoltán Mészár, Éva Kókai, Rita Varga, László Ducza, Tamás Papp, Monika Béresová, Marianna Nagy, Péter Szücs, Angelika Varga

Journal: Int J Mol Sci

PubMed ID: 35328599

Doi: 10.3390/ijms23063178

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A jacalin-like lectin domain-containing protein of Sclerospora graminicola acts as an apoplastic virulence effector in plant-oomycete interactions

Authors: Michie Kobayashi, Hiroe Utsushi, Koki Fujisaki, Takumi Takeda, Tetsuro Yamashita, Ryohei Terauchi

Journal: Mol Plant Pathol

PubMed ID: 35257477

Doi: 10.1111/mpp.13197

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Engineering a synthesis-friendly serum responsive promoter for antibiotic selection of genomic integration in cell-based therapy

Authors: Chee Ka Candice Lam, Kevin Truong

Journal: Biotechnol Lett

PubMed ID: 35294696

Doi: 10.1007/s10529-022-03244-z

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Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling

Authors: Maricel Gomez-Soler, Marina P. Gehring, Bernhard C. Lechtenberg,Elmer Zapata-Mercado, Alyssa Ruelos,Mike W. Matsumoto,Kalina Hristova,and Elena B. Pasquale

Journal: iScience

Doi: doi.org/10.1016/j.isci.2022.103870

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Global profiling of regulatory elements in the histone benzoylation pathway

Authors: Duo Wang , Fuxiang Yan , Ping Wu, Kexue Ge , Muchun Li , Tingting Li , Ying Gao , Chao Peng , Yong Chen

Journal: Nat Commun

PubMed ID: 35296687

Doi: 10.1038/s41467-022-29057-2

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A multifunctional enolase mediates cytoadhesion and interaction with host plasminogen and fibronectin in Mycoplasma hyorhinis

Authors: Jia Wang , Yanfei Yu , Yao Li , Shiyang Li , Li Wang , Yanna Wei , Yuzi Wu , Bala Pillay , Ademola Olufolahan Olaniran , Thamsanqa E Chiliza , Guoqing Shao , Zhixin Feng , Qiyan Xiong

Journal: Vet Res

PubMed ID: 35337383

Doi: 10.1186/s13567-022-01041-0

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Functional Antagonism of Junctional Adhesion Molecule-A (JAM-A), Overexpressed in Breast Ductal Carcinoma In Situ (DCIS), Reduces HER2-Positive Tumor Progression

Authors: Yvonne E Smith, Guannan Wang, Ciara L Flynn, Stephen F Madden, Owen MacEneaney, Rodrigo G B Cruz, Cathy E Richards, Hanne Jahns, Marian Brennan, Mattia Cremona, Bryan T Hennessy, Katherine Sheehan, Alexander Casucci, Faizah A Sani, Lance Hudson, Joanna Fay, Sri H Vellanki, Siobhan O'Flaherty, Marc Devocelle, Arnold D K Hill, Kieran Brennan, Saraswati Sukumar, Ann M Hopkins

Journal: Cancers (Basel)

PubMed ID: 35267611

Doi: 10.3390/cancers14051303

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A Protein vaccine with Alum/c-GAMP/poly(I:C) rapidly boosts robust immunity against SARS-CoV-2 and variants of concern

Authors: Ru-Yan Zhang , Xu-Guang Yin , Shi-Hao Zhou , Hai-Wei Zhang , Jie Lu , Chen-Bin He , Jian Wang , Yu Wen , Yu-Ting Li , Yan-Ling Liu , Ran-Ran Feng , Dong Ding , Hua-Wei Wei , Rui Gong , Guang-Fu Yang , Jun Guo

Journal: Chem Commun

PubMed ID: 35244125

Doi: 10.1039/D2CC00271J

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A TCR mimic monoclonal antibody reactive with the "public" phospho-neoantigen pIRS2/HLA-A*02:01 complex

Authors: Tao Dao, Sung Soo Mun, Zaki Molvi, Tatyana Korontsvit, Martin G Klatt, Abdul G Khan, Elisabeth K Nyakatura, Mary Ann Pohl, Thomas E White, Paul J Balderes, Ivo C Lorenz, Richard J O'Reilly, David A Scheinberg

Journal: JCI Insight

PubMed ID: 35260532

Doi: 10.1172/jci.insight.151624

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Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules

Authors: Hui Jin, Kazuki Kishida, Noriko Arase, Sumiko Matsuoka, Wataru Nakai, Masako Kohyama, Tadahiro Suenaga, Ken Yamamoto, Takehiko Sasazuki, Hisashi Arase

Journal: Sci Adv

PubMed ID: 35245125

Doi: 10.1126/sciadv.abj9867

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Immunity to SARS-CoV-2: What Do We Know and Should We Be Testing for It?

Authors: Anisha Misra, Elitza S Theel

Journal: J Clin Microbiol

PubMed ID: 35249377

Doi: 10.1128/jcm.00482-21

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Association of Homologous and Heterologous Vaccine Boosters With COVID-19 Incidence and Severity in Singapore

Authors: Sharon Hui Xuan Tan, Rachael Pung, Lin-Fa Wang, David Chien Lye, Benjamin Ong, Alex R Cook, Kelvin Bryan Tan

Journal: JAMA

PubMed ID: 35147657

Doi: 10.1001/jama.2022.1922

Elucidating the Novel Mechanism of Ligustrazine in Preventing Postoperative Peritoneal Adhesion Formation

Authors: Lili Yang, Zhengjun Li, Yao Chen, Feiyan Chen, Haopeng Sun, Min Zhao, Yanqi Chen, Yali Wang, Wenlin Li, Li Zeng, Yaoyao Bian

Journal: Oxid Med Cell Longev

PubMed ID: 35308169

Doi: 10.1155/2022/9226022

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Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway

Authors: Yang Bai, Jiaqi Chen, Weijian Hu, Lei Wang, Yulian Wu, Shi'an Yu

Journal: Front Pharmacol

PubMed ID: 35401195

Doi: 10.3389/fphar.2022.847905

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Function and Application of the CRISPR-Cas System in the Plant Pathogen

Authors: Michael Parcey, Steven Gayder, Alan J Castle, Antonet M Svircev

Journal: Appl Environ Microbiol

PubMed ID: 35285707

Doi: 10.1128/aem.02513-21

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Cellular assays identify barriers impeding iron-sulfur enzyme activity in a non-native prokaryotic host

Authors: Francesca D'Angelo, Elena Fernández-Fueyo, Pierre Simon Garcia, Helena Shomar, Martin Pelosse, Rita Rebelo Manuel, Ferhat Büke, Siyi Liu, Niels van den Broek, Nicolas Duraffourg, Carol de Ram, Martin Pabst, Emmanuelle Bouveret, Simonetta Gribaldo, Béatrice Py, Sandrine Ollagnier de Choudens, Frédéric Barras, Gregory Bokinsky

Journal: Elife

PubMed ID: 35244541

Doi: 10.7554/eLife.70936

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α-Melanocyte-stimulating hormone inhibition of oxytocin neurons switches to excitation in late pregnancy and lactation

Authors: Michael R Perkinson, Matthew K Kirchner, Meng Zhang, Rachael A Augustine, Javier E Stern, Colin H Brown

Journal: Physiol Rep

PubMed ID: 35312181

Doi: 10.14814/phy2.15226

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N-gene-complementary antisense-oligonucleotide directed molecular aggregation of dual-colour carbon dots, leading to efficient fluorometric sensing of SARS-COV-2 RNA

Authors: Zach Sheffield, Maha Alafeef, Parikshit Moitra, Priyanka Ray, Dipanjan Pan

Journal: Nanoscale

PubMed ID: 35297914

Doi: 10.1039/d1nr07169f

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Assay design for unambiguous identification and quantification of circulating pathogen-derived peptide biomarkers

Authors: Qingbo Shu, Shan Liu, Tonino Alonzi, Sylvia M LaCourse, Dhiraj Kumar Singh, Duran Bao, Dalton Wamalwa, Li Jiang, Christopher J Lyon, Grace John-Stewart, Deepak Kaushal, Delia Goletti, Tony Hu

Journal: Theranostics

PubMed ID: 35401822

Doi: 10.7150/thno.70373

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Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice

Authors: Saurav S Rout, Yunyun Di, Ulf Dittmer, Kathrin Sutter, Kerry J Lavender

Journal: AIDS

PubMed ID: 35084382

Doi: 10.1097/QAD.0000000000003111

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Porcine circovirus 4 rescued from an infectious clone is replicable and pathogenic in vivo

Authors: Guyu Niu, Xinwei Zhang, Weilong Ji, Si Chen, Xue Li, Lin Yang, Liying Zhang, Hongsheng Ouyang, Chang Li, Linzhu Ren

Journal: Transbound Emerg Dis

PubMed ID: 35240007

Doi: 10.1111/tbed.14498

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Metabolic engineering of Saccharomyces cerevisiae for gram-scale diosgenin production

Authors: Liping Xu , Dong Wang , Jing Chen , Bo Li , Qingyan Li , Pingping Liu , Ying Qin , Zhubo Dai , Feiyu Fan , Xueli Zhang

Journal: Metab Eng

PubMed ID: 35085779

Doi: 10.1016/j.ymben.2022.01.013

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A compact and simple method of achieving differential transgene expression by exploiting translational readthrough

Authors: James E Sillibourne, Giulia Agliardi, Matteo Righi, Katerina Smetanova, Grant Rowley, Simon Speller, Abigail Dolor, Katarina Lamb, Christopher Allen, Rajeev Karattil, Farhaan Parekh, Frederick Arce Vargas, Simon Thomas, Shaun Cordoba, Martin Pule

Journal: BioTechniques

PubMed ID: 35234525

Doi: 10.2144/btn-2021-0079

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Targeting an evolutionarily conserved "E-L-L" motif in the spike protein to develop a small molecule fusion inhibitor against SARS-CoV-2

Authors: Indrani Das Jana, Prabuddha Bhttacharya, Karthick Mayilsamy, Saptarshi Banerjee, Gourab Bhattacharje, Sayan Das, Seemanti Aditya, Anandita Ghosh, Andrew R McGill, Syamanthak Srikrishnan, Amit Kumar Das, Amit Basak, Shyam S Mohapatra, Bala Chandran, Devesh Bhimsaria, Subhra Mohapatra, Arunava Roy, Arindam Mondal

Journal: biorxiv

PubMed ID: 35313575

Doi: 10.1101/2022.03.16.484554

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OsASHL1 and OsASHL2, two members of the COMPASS-like complex, control floral transition and plant development in rice

Authors: Guangxin Zhao, Jingying Wang, Xi Chen, Hanjing Sha, Xin Liu, Yunfei Han, Guankai Qiu, Fantao Zhang, Jun Fang

Journal: J Genet Genomics

PubMed ID: 35306222

Doi: 10.1016/j.jgg.2022.02.026

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Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

Authors: Anusmita Sahoo, Edgar A Hodge, Celia C LaBranche, Tiffany M Styles, Xiaoying Shen, Narayanaiah Cheedarla, Ayalnesh Shiferaw, Gabriel Ozorowski, Wen-Hsin Lee, Andrew B Ward, Georgia D Tomaras, David C Montefiori, Darrell J Irvine, Kelly K Lee, Rama Rao Amara

Journal: Cell Rep

PubMed ID: 35235790

Doi: 10.1016/j.celrep.2022.110436

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Study of osmoadaptation mechanisms of halophilic Halomonas alkaliphila XH26 under salt stress by transcriptome and ectoine analysis

Authors: Tiantian Zhang, Xin Zhang, Yongzhen Li, Ning Yang, Lijuan Qiao, Zengqiang Miao, Jiangwa Xing, Derui Zhu

Journal: Extremophiles

PubMed ID: 35229247

Doi: 10.1007/s00792-022-01256-1

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Targeting insulin-like growth factor-1 receptor (IGF1R) for brain delivery of biologics

Authors: Wael Alata, Alvaro Yogi, Eric Brunette, Christie E Delaney, Henk van Faassen, Greg Hussack, Umar Iqbal, Kristin Kemmerich, Arsalan S Haqqani, Maria J Moreno, Danica B Stanimirovic

Journal: FASEB J

PubMed ID: 35192204

Doi: 10.1096/fj.202101644R

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ACTL6a coordinates axonal caliber recognition and myelination in the peripheral nerve

Authors: Hye-Jin Park, Eric Tsai, Dennis Huang, Michael Weaver, Luciana Frick, Ace Alcantara, John J Moran, Julia Patzig, Carmen V Melendez-Vasquez, Gerald R Crabtree, M L Feltri, John Svaren, Patrizia Casaccia

Journal: iScience

PubMed ID: 35434551

Doi: 10.1016/j.isci.2022.104132

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Undiagnosed COVID-19 in households with a child with mitochondrial disease

Authors: Eliza M Gordon-Lipkin, Christopher Marcum, Shannon Kruk, Elizabeth Thompson, Sophie E M Kelly, Heather Kalish, Kaitlyn Sadtler, Peter J McGuire

Journal: medrxiv

PubMed ID: 35350208

Doi: 10.1101/2022.03.21.22272358

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MdMTA-mediated m A modification enhances drought tolerance by promoting mRNA stability and translation efficiency of genes involved in lignin deposition and oxidative stress

Authors: Nan Hou, Chaoshuo Li, Jieqiang He, Yu Liu, Sisi Yu, Mickael Malnoy, Muhammad Mobeen Tahir, Lingfei Xu, Fengwang Ma, Qingmei Guan

Journal: New Phytol

PubMed ID: 35246985

Doi: 10.1111/nph.18069

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PINK1/Parkin-mediated mitophagy is activated to protect against AFB-induced kidney damage in mice

Authors: Yuping Wang, Miao Song, Qi Wang, Chen Guo, Jian Zhang, Xuliang Zhang, Yilong Cui, Zheng Cao, Yanfei Li

Journal: Chem Biol Interact

PubMed ID: 35304092

Doi: 10.1016/j.cbi.2022.109884

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A randomized clinical trial of a booster dose with low versus standard dose of AZD1222 in adult after 2 doses of inactivated vaccines

Authors: Sira Nanthapisal, Thanyawee Puthanakit, Peera Jaru-Ampornpan, Rapisa Nantanee, Pimpayao Sodsai, Orawan Himananto, Jiratchaya Sophonphan, Pintip Suchartlikitwong, Narin Hiransuthikul, Pornpimon Angkasekwinai, Auchara Tangsathapornpong, Nattiya Hirankarn

Journal: Vaccine

PubMed ID: 35341647

Doi: 10.1016/j.vaccine.2022.03.036

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Overexpression of microRNA-107 suppressed proliferation, migration, invasion, and the PI3K/Akt signaling pathway and induced apoptosis by targeting Nin one binding (NOB1) protein in a hypopharyngeal squamous cell carcinoma cell line (FaDu)

Authors: Xin Gao, Xinlong Fan, Wei Zeng, Jiwang Liang, Nan Guo, Xiao Yang, Yuejiao Zhao

Journal: Bioengineered

PubMed ID: 35294329

Doi: 10.1080/21655979.2022.2051266

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Simultaneous Detection of Bladder Cancer Exosomal MicroRNAs Based on Inorganic Nanoflare and DNAzyme Walker

Authors: Xiao Zhang, Xiaowei Wei, Jijin Qi, Jie Shen, Junwen Xu, Guangyu Gong, Yong Wei, Jian Yang, Qingyi Zhu, Tingting Bai, Zhirui Guo, Xiaojun Qu, Yefei Zhu

Journal: Anal Chem

PubMed ID: 35275615

Doi: 10.1021/acs.analchem.1c05588

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Characterization of Bud3 domains sufficient for bud neck targeting in

Authors: Madison N Schrock, Yao Yan, Megan E Goeckel, Erianna M Basgall, Isabel C Lewis, Katherine G Leonard, Megan Halloran, Gregory C Finnigan

Journal: Access Microbiol

PubMed ID: 35693471

Doi: 10.1099/acmi.0.000341

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Comparative performance of five recombinant and chimeric antigens in a time-resolved fluorescence immunoassay for detection of Toxoplasma gondii infection in cats

Authors: Ana Huertas-López, Marinela Contreras Rojo, Woraporn Sukhumavasi, Silvia Martínez-Subiela, Gema Álvarez-García, Nadia María López-Ureña, José Joaquín Cerón, Carlos Martínez-Carrasco

Journal: Vet Parasitol

PubMed ID: 35367904

Doi: 10.1016/j.vetpar.2022.109703

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The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells

Authors: Balaji T Moorthy, Chunhua Jiang, Devang M Patel, Yuguang Ban, Corin R O'Shea, Akhilesh Kumar, Tan Yuan, Michael D Birnbaum, Aldrin V Gomes, Xi Chen, Flavia Fontanesi, Theodore J Lampidis, Antoni Barrientos, Fangliang Zhang

Journal: Dev Cell

PubMed ID: 35247316

Doi: 10.1016/j.devcel.2022.02.010

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A toolkit for recombinant production of seven human EGF family growth factors in active conformation

Authors: Arthur Schveitzer Ferreira, Amanda Lopacinski, Michel Batista, Priscila Mazzocchi Hiraiwa, Beatriz Gomes Guimarães, Nilson Ivo Tonin Zanchin

Journal: Sci Rep

PubMed ID: 35322149

Doi: 10.1038/s41598-022-09060-9

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Expression of B subtilis Phytase gene driven by fruit specific E8 promoter for enhanced minerals, metabolites and phytonutrient in cucumber fruit

Authors: Komal K Sapara, Parinita Agarwal, Kapil Gupta, Pradeep K Agarwal

Journal: Food Res Int

PubMed ID: 35651010

Doi: 10.1016/j.foodres.2022.111138

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A multi-epitopes tandem antigen for five types of human adenoviruses and its application in development of multivalent IgM immunochromatographic strip test

Authors: Liqiang Zong, Yong Qi, Wei Li, Wanpeng Shen, Jiameng Li, Ruichen Lv, Nianhong Lu, Susu Zhuang, Qiyuan Gui, Dongming Zhou, Yingjia Xu, Zhao Nan, Yuexi Li

Journal: Diagn Microbiol Infect Dis

PubMed ID: 35378470

Doi: 10.1016/j.diagmicrobio.2022.115675

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Exogenous Annexin 1 inhibits Th17 cell differentiation induced by anti-TNF treatment via activating FPR2 in DSS-induced colitis

Authors: Xing Liu, Lulu Zhou, Wenjie Xin, Zichun Hua

Journal: Int Immunopharmacol

PubMed ID: 35306282

Doi: 10.1016/j.intimp.2022.108685

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Tick Intrastadial Feeding and Its Role on IgE Production in the Murine Model of Alpha-gal Syndrome: The Tick "Transmission" Hypothesis

Authors: L Paulina Maldonado-Ruiz, Gunavanthi D Boorgula, Donghun Kim, Sherry D Fleming, Yoonseong Park

Journal: Front Immunol

PubMed ID: 35309294

Doi: 10.3389/fimmu.2022.844262

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Enabling Efficient Genetic Manipulations in a Rare Actinomycete Shahu

Authors: Jie Li, Baiyang Wang, Qing Yang, Han Si, Yuting Zhao, Yanli Zheng, Wenfang Peng

Journal: Front Microbiol

PubMed ID: 35308340

Doi: 10.3389/fmicb.2022.848964

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Spherical nucleic acids as an infectious disease vaccine platform

Authors: Michelle H Teplensky, Max E Distler, Caroline D Kusmierz, Michael Evangelopoulos, Haley Gula, Derek Elli, Anastasia Tomatsidou, Vlad Nicolaescu, Ian Gelarden, Anjana Yeldandi, Daniel Batlle, Dominique Missiakas, Chad A Mirkin

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35312341

Doi: 10.1073/pnas.2119093119

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A thermostable Cas12b from Brevibacillus leverages one-pot discrimination of SARS-CoV-2 variants of concern

Authors: Long T Nguyen, Nicolas C Macaluso, Brianna L M Pizzano, Melanie N Cash, Jan Spacek, Jan Karasek, Megan R Miller, John A Lednicky, Rhoel R Dinglasan, Marco Salemi, Piyush K Jain

Journal: EBioMedicine

PubMed ID: 35290826

Doi: 10.1016/j.ebiom.2022.103926

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Influence of Proteolysis on the Binding Capacity of Flavor Compounds to Myofibrillar Proteins

Authors: Hao Li, Rui Zheng, Fangfang Zuo, Chengyu Qian, Zhengan Yao, Ruipeng Dong, Di Zhao, Chunbao Li

Journal: Foods

PubMed ID: 35327313

Doi: 10.3390/foods11060891

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Robust, persistent adaptive immune responses to SARS-CoV-2 in the oropharyngeal lymphoid tissue of children

Authors: Kalpana Manthiram, Qin Xu, Pedro Milanez-Almeida, Andrew Martins, Andrea Radtke, Kenneth Hoehn, Jinguo Chen, Can Liu, Juanjie Tang, Gabrielle Grubbs, Sydney Stein, Sabrina Ramelli, Juraj Kabat, Hengameh Behzadpour, Maria Karkanitsa, Jacquelyn Spathies, Heather Kalish, Lela Kardava, Martha Kirby, Foo Cheung, Silvia Preite, Patrick Duncker, Nahir Romero, Diego Preciado, Lyuba Gitman, Galina Koroleva, Grace Smith, Arthur Shaffer, Ian McBain, Stefania Pittaluga, Ronald Germain, Richard Apps, Kaitlyn Sadtler, Susan Moir, Daniel Chertow, Steven Kleinstein, Surender Khurana, John Tsang, Pamela Mudd, Pamela Schwartzberg

Journal: Res Sq

PubMed ID: 35350206

Doi: 10.21203/rs.3.rs-1276578/v1

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An In Vivo Screen to Identify Short Peptide Mimotopes with Enhanced Antitumor Immunogenicity

Authors: Xuedan He, Shiqi Zhou, Breandan Quinn, Dushyant Jahagirdar, Joaquin Ortega, Mark D Long, Scott I Abrams, Jonathan F Lovell

Journal: Cancer Immunol Res

PubMed ID: 34992135

Doi: 10.1158/2326-6066.CIR-21-0332

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