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Estimating the Neutralizing Effect and Titer Correlation of Semi-Quantitative Anti-SARS-CoV-2 Antibody Immunoassays

Authors: Beomki Lee, Jae-Hoon Ko, Jiho Park, Hee-Won Moon, Jin Yang Baek, Sunhee Jung, Hee-Young Lim, Kyung-Chang Kim, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Hee Jae Huh, Chi Ryang Chung, Yae-Jean Kim, Eun-Jeong Joo, Eun-Suk Kang, Kyong Ran Peck

Journal: Front Cell Infect Microbiol

PubMed ID: 35493733

Doi: 10.3389/fcimb.2022.822599

Engineered RBCs Encapsulating Antigen Induce Multi-Modal Antigen-Specific Tolerance and Protect Against Type 1 Diabetes

Authors: Colin J Raposo, Judith D Cserny, Gloria Serena, Jonathan N Chow, Patricia Cho, Hanyang Liu, David Kotler, Armon Sharei, Howard Bernstein, Shinu John

Journal: Front Immunol

PubMed ID: 35444659

Doi: 10.3389/fimmu.2022.869669

Products & Services: Proteins, Expression, Isolation and Analysis

Role of the anillin-like protein in growth of Cryptococcus neoformans at human host temperature

Authors: Congyue A Peng, Sophie Altamirano, Namrata Paladugu, Logan P Crowe, Inas F Aboobakar, Srikripa Chandrasekaran, Lukasz Kozubowski

Journal: Fungal Genet Biol

PubMed ID: 35472450

Doi: 10.1016/j.fgb.2022.103697

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Efficient exploration of terpenoid biosynthetic gene clusters in filamentous fungi

Authors: Yujie Yuan, Shu Cheng, Guangkai Bian, Pan Yan, Zhengning Ma, Wen Dai, Rong Chen, Shuai Fu, Huiwen Huang, Haoming Chi, Yousheng Cai, Zixin Deng & Tiangang Liu

Journal: Nature Catalysis

Doi: 10.1038/s41929-022-00762-x

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Indirubin-3’-monoxime acts as proteasome inhibitor:Therapeutic application in multiple myeloma

Authors: Zhen Yu , Xiaojing Wei , Lanting Liu , Hao Sun , Teng Fang , Lu Wang , Ying Li , Weiwei Sui , Kefei Wang , Yi He , Yaozhong Zhao , Wenyang Huang , Gang An , Fancui Meng , Changjiang Huang , Tengteng Yu , Kenneth C Anderson , Tao Cheng , Lugui Qiu , Mu Hao

Journal: EBioMedicine

PubMed ID: 35344764

Doi: 10.1016/j.ebiom.2022.103950

Products & Services: Proteins, Expression, Isolation and Analysis

Specification of CNS macrophage subsets occurs postnatally in defined niches

Authors: Takahiro Masuda, Lukas Amann, Gianni Monaco, Roman Sankowski, Ori Staszewski, Martin Krueger, Francesca Del Gaudio, Liqun He, Neil Paterson, Elisa Nent, Francisco Fernández-Klett, Ayato Yamasaki, Maximilian Frosch, Maximilian Fliegauf, Lance Fredrick Pahutan Bosch, Hatice Ulupinar, Nora Hagemeyer, Dietmar Schreiner, Cayce Dorrier, Makoto Tsuda, Claudia Grothe, Anne Joutel, Richard Daneman, Christer Betsholtz, Urban Lendahl, Klaus-Peter Knobeloch, Tim Lämmermann, Josef Priller, Katrin Kierdorf, Marco Prinz

Journal: Nature

PubMed ID: 35444273

Doi: 10.1038/s41586-022-04596-2

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Real meat and plant-based meat analogues have different in vitro protein digestibility properties

Authors: Yunting Xie, Linlin Cai, Di Zhao, Hui Liu, Xinglian Xu, Guanghong Zhou, Chunbao Li

Journal: Food Chem

PubMed ID: 35413556

Doi: 10.1016/j.foodchem.2022.132917

Products & Services: Proteins, Expression, Isolation and Analysis

Alternative splicing of an exitron determines the subnuclear localization of the Arabidopsis DNA glycosylase MBD4L under heat stress

Authors: Nicolás Miguel Cecchini , José Roberto Torres , Ignacio Lescano López, Santiago Cobo, Florencia Nota, María Elena Alvarez

Journal: Plant J

PubMed ID: 35061303

Doi: 10.1111/tpj.15675

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Premetazoan Origin of Neuropeptide Signaling

Authors: Luis Alfonso Yañez-Guerra, Daniel Thiel, Gáspár Jékely

Journal: Mol Biol Evol

PubMed ID: 35277960

Doi: 10.1093/molbev/msac051

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Structural insights into the peptide selectivity and activation of human neuromedin U receptors

Authors: Chongzhao You , Yumu Zhang , Peiyu Xu , Sijie Huang , Wanchao Yin, H Eric Xu , Yi Jiang

Journal: Nat Commun

PubMed ID: 35440625

Doi: 10.1038/s41467-022-29683-w

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Family 1 Glycosyltransferase UGT706F8 from Selectively Catalyzes the Synthesis of Silibinin 7--β-d-Glucoside

Authors: Gonzalo N Bidart, Natalia Putkaradze, Folmer Fredslund, Christian Kjeldsen, Ander Garralda Ruiz, Jens Ø Duus, David Teze, Ditte H Welner

Journal: ACS Sustain Chem Eng

PubMed ID: 35493695

Doi: 10.1021/acssuschemeng.1c07593

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Development of Antifungal Peptides against Cryptococcus neoformans; Leveraging Knowledge about the Mutant Susceptibility for Lead Compound Development

Authors: Robert J Tancer, Yina Wang, Siddhi Pawar, Chaoyang Xue, Gregory R Wiedman

Journal: Microbiol Spectr

PubMed ID: 35377230

Doi: 10.1128/spectrum.00439-22

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Novel insight into the transformation of peptides and potential benefits in brown fermented goat milk by mesoporous magnetic dispersive solid phase extraction-based peptidomics

Authors: Wei Jia, An Du, Zibian Fan, Lin Shi

Journal: Food Chem

PubMed ID: 35504074

Doi: 10.1016/j.foodchem.2022.133110

Products & Services: Proteins, Expression, Isolation and Analysis

The C-Terminal Transmembrane Domain of Cowpea Mild Mottle Virus TGBp2 Is Critical for Plasmodesmata Localization and for Its Interaction With TGBp1 and TGBp3

Authors: Chong Jiang, Shiqi Shan, Yue Huang, Chenyang Mao, Hehong Zhang, Yanjun Li, Jianping Chen, Zhongyan Wei, Zongtao Sun

Journal: Front Microbiol

PubMed ID: 35495691

Doi: 10.3389/fmicb.2022.860695

Products & Services: Proteins, Expression, Isolation and Analysis

The Copper Resistome of Group B Streptococcus Reveals Insight into the Genetic Basis of Cellular Survival during Metal Ion Stress

Authors: Kelvin G K Goh, Matthew J Sullivan, Glen C Ulett

Journal: J Bacteriol

PubMed ID: 35404113

Doi: 10.1128/jb.00068-22

Products & Services: Mutant Libraries

N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system

Authors: Feng Jiang, Jiawei Shen, Jiaxuan Cheng, Xia Wang, Jianguo Yang, Ningning Li, Ning Gao, Qi Jin

Journal: Sci Adv

PubMed ID: 35486720

Doi: 10.1126/sciadv.abm2343

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Multi-Omics Analysis Reveals That Synergistically Regulates SGAs and Fruit Development

Authors: Hao Guo, Mengdi Mao, Yuan Deng, Lisong Sun, Ridong Chen, Peng Cao, Jun Lai, Yueran Zhang, Chao Wang, Chun Li, Yiran Li, Qunhang Bai, Tingting Tan, Jun Yang, Shouchuang Wang

Journal: Front Plant Sci

PubMed ID: 35463452

Doi: 10.3389/fpls.2022.860577

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Artemether inhibits proliferation, invasion and migration of hepatocellular carcinoma cells via targeting of CYP2J2

Authors: Xionglin Zhu, Mei Yang, Zhiling Song, Guangbing Yao, Qifeng Shi

Journal: Oncol Lett

PubMed ID: 35464300

Doi: 10.3892/ol.2022.13300

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Hypericin nanoparticles for self-illuminated photodynamic cytotoxicity based on bioluminescence resonance energy transfer

Authors: Hao-Han Yu, Qiu-Ping Deng, Qing-Hua Zheng, Yi Wang, Jian Shen, Jia-Hong Zhou

Journal: Int J Pharm

PubMed ID: 35427744

Doi: 10.1016/j.ijpharm.2022.121738

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Characterization of Calcium-Dependent Protein Kinase 2A, a Potential Drug Target Against Cryptosporidiosis

Authors: Fanfan Shu, Yu Li, Wenlun Chu, Xuehua Chen, Ziding Zhang, Yaqiong Guo, Yaoyu Feng, Lihua Xiao, Na Li

Journal: Front Microbiol

PubMed ID: 35558125

Doi: 10.3389/fmicb.2022.883674

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Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24

Authors: Lingguang Yang, Laixing Zhang, Peipei Yin, Hao Ding, Yu Xiao, Jianwei Zeng, Wenhe Wang, Huan Zhou, Qisheng Wang, Yi Zhang, Zeliang Chen, Maojun Yang, Yue Feng

Journal: Nat Commun

PubMed ID: 35411005

Doi: 10.1038/s41467-022-29581-1

Products & Services: Mutant Libraries

The structure of Phocaeicola vulgatus sialic acid acetylesterase

Authors: Hannah Scott, Gideon J Davies, Zachary Armstrong

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35503212

Doi: 10.1107/S2059798322003357

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Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Authors: Chao Wang, Li Fan, Rabia R Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T Grinberg, William W Seeley, Bruce L Miller, Sue-Ann Mok, Jason E Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Gan

Journal: Nat Commun

PubMed ID: 35413950

Doi: 10.1038/s41467-022-29552-6

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Mechanism of RNA polymerase I selection by transcription factor UAF

Authors: Florence Baudin, Brice Murciano, Herman K H Fung, Simon A Fromm, Simone Mattei, Julia Mahamid, Christoph W Müller

Journal: Sci Adv

PubMed ID: 35442737

Doi: 10.1126/sciadv.abn5725

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A Novel Homozygous Variant Leading to Type-1 Familial Glucocorticoid Deficiency

Authors: Idris Mohammed, Basma Haris, Khalid Hussain

Journal: J Endocr Soc

PubMed ID: 35506146

Doi: 10.1210/jendso/bvac058

Products & Services: Plasmid DNA Preparation

MIMAS: microfluidic platform in tandem with MALDI mass spectrometry for protein quantification from small cell ensembles

Authors: Jorvani Cruz Villarreal, Rory Kruithoff, Ana Egatz-Gomez, Paul D Coleman, Robert Ros, Todd R Sandrin, Alexandra Ros

Journal: Anal Bioanal Chem

PubMed ID: 35385983

Doi: 10.1007/s00216-022-04038-y

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Expanding the Editing Window of Cytidine Base Editors With the Rad51 DNA-Binding Domain in Rice

Authors: Chunjie Wei, Hao Liu, Wenwen Wang, Pengyu Luo, Qiuling Chen, Rou Li, Chong Wang, José Ramón Botella, Hui Zhang

Journal: Front Plant Sci

PubMed ID: 35548314

Doi: 10.3389/fpls.2022.865848

Products & Services: Mammalian Expression

Secretes Small RNA to Target Host and Retard Plant Floral Transition During Infection

Authors: Bo-Sen Zhang, Ying-Chao Li, Hui-Shan Guo, Jian-Hua Zhao

Journal: Front Plant Sci

PubMed ID: 35519822

Doi: 10.3389/fpls.2022.847086

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SNX27-Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling

Authors: Boris Simonetti, Qian Guo, Manuel Giménez-Andrés, Kai-En Chen, Edmund R R Moody, Ashley J Evans, Mintu Chandra, Chris M Danson, Tom A Williams, Brett M Collins, Peter J Cullen

Journal: PLoS Biol

PubMed ID: 35417450

Doi: 10.1371/journal.pbio.3001601

Products & Services: Proteins, Expression, Isolation and Analysis

Cellular Immune Response in Patients Immunized with Three Vaccine Doses of Different Vaccination Schemes Authorized by the Chilean Ministry of Health in January 2022

Authors: Paz Beatriz Tabilo Valenzuela, Gabriela Flores Balter, Gustavo Saint-Pierre Contreras, Daniel Conei Valencia, Catalina Moreno Calderón, Constanza Bohle Venegas, Marcia Guajardo Rivera, Francisco Silva Ojeda, Maria Jesus Vial Covarrubias

Journal: Life (Basel)

PubMed ID: 35455024

Doi: 10.3390/life12040534

Products & Services: Proteins, Expression, Isolation and Analysis

A Novel Multi-Epitope Edible Vaccine Candidate for Newcastle Disease Virus: Approach

Authors: Atena Mozafari, Jafar Amani, Shahla Shahsavandi, Ali Hatef Salmanian

Journal: Iran J Biotechnol

PubMed ID: 36337069

Doi: 10.30498/ijb.2022.298822.3119

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Inhibitor of DNA binding 2 (ID2) regulates the expression of developmental genes and tumorigenesis in ewing sarcoma

Authors: Stacia L Koppenhafer, Kelli L Goss, Ellen Voigt, Emma Croushore, William W Terry, Jason Ostergaard, Peter M Gordon, David J Gordon

Journal: Oncogene

PubMed ID: 35422476

Doi: 10.1038/s41388-022-02310-0

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Immunization With Recombinant Y75B8A8 Partially Protects Local Crossbred Female Goats From Infection

Authors: Xiaowei Tian, Mingmin Lu, Yongqian Bu, Yang Zhang, Kalibixiati Aimulajiang, Meng Liang, Charles Li, Ruofeng Yan, Lixin Xu, Xiaokai Song, Xiangrui Li

Journal: Front Vet Sci

PubMed ID: 35445096

Doi: 10.3389/fvets.2022.765700

Products & Services: Proteins, Expression, Isolation and Analysis

The miR-532-E2F1 feedback loop contributes to gastric cancer progression

Authors: Shanting Gao, Xiaomin Bu, Yongyue Gao, Zengtao Bao, Wenchao Shi, Lipeng Luan, Huiyu Chen, Baoming Zhang, Qingshui Tian, Wenxian Guan, Liuqing Yang

Journal: Cell Death Dis

PubMed ID: 35440106

Doi: 10.1038/s41419-022-04832-7

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is a 3D matrix-specific mediator of mechanosensitive stem cell lineage commitment

Authors: Jieung Baek, Paola A Lopez, Sangmin Lee, Taek-Soo Kim, Sanjay Kumar, David V Schaffer

Journal: Sci Adv

PubMed ID: 35427160

Doi: 10.1126/sciadv.abm4646

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Dynamics of Neutralizing Antibody and T-Cell Responses to SARS-CoV-2 and Variants of Concern after Primary Immunization with CoronaVac and Booster with BNT162b2 or ChAdOx1 in Health Care Workers

Authors: Watsamon Jantarabenjakul, Pimpayao Sodsai, Napaporn Chantasrisawad, Anusara Jitsatja, Sasiprapa Ninwattana, Nattakarn Thippamom, Vichaya Ruenjaiman, Chee Wah Tan, Rakchanok Pradit, Jiratchaya Sophonphan, Supaporn Wacharapluesadee, Lin-Fa Wang, Thanyawee Puthanakit, Nattiya Hirankarn, Opass Putcharoen

Journal: Vaccines (Basel)

PubMed ID: 35632395

Doi: 10.3390/vaccines10050639

Products & Services: Recombinant Proteins

Type XX Collagen Is Elevated in Circulation of Patients with Solid Tumors

Authors: Jeppe Thorlacius-Ussing, Christina Jensen, Emilie A Madsen, Neel I Nissen, Tina Manon-Jensen, Inna M Chen, Julia S Johansen, Hadi M H Diab, Lars N Jørgensen, Morten A Karsdal, Nicholas Willumsen

Journal: Int J Mol Sci

PubMed ID: 35456962

Doi: 10.3390/ijms23084144

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Characterization of BLUF-photoreceptors present in Acinetobacter nosocomialis

Authors: Inés Abatedaga, Bárbara Perez Mora, Marisel Tuttobene, Gabriela Müller, Daiana Biancotti, Claudio D Borsarelli, Lorena Valle, Maria A Mussi

Journal: PLoS ONE

PubMed ID: 35442978

Doi: 10.1371/journal.pone.0254291

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Suppression of lysosomal-associated protein transmembrane 5 ameliorates cardiac function and inflammatory response by inhibiting the nuclear factor-kappa B (NF-κB) pathway after myocardial infarction in mice

Authors: Zhanchun Song, Xiaozeng Wang, Lianqi He, Liang Chen, Zhichao Ren, Siyu Song

Journal: Exp Anim

PubMed ID: 35491099

Doi: 10.1538/expanim.22-0008

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A single point mutation in the Plasmodium falciparum 3'-5' exonuclease does not alter piperaquine susceptibility

Authors: Nonlawat Boonyalai, Kirakarn Kirativanich, Chatchadaporn Thamnurak, Chantida Praditpol, Brian A Vesely, Mariusz Wojnarski, John S Griesenbeck, Norman C Waters

Journal: Malar J

PubMed ID: 35459163

Doi: 10.1186/s12936-022-04148-z

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A Novel Immunochromatographic Strip Based on Latex Microspheres for the Rapid Detection of North American-Type Porcine Reproductive and Respiratory Syndrome Virus

Authors: Wansheng Li, Minhua Li, Hongliang Zhang, Chao Li, Hu Xu, Bangjun Gong, Jun Fu, Zhenyang Guo, Jinmei Peng, Guohui Zhou, Zhijun Tian, Qian Wang

Journal: Front Microbiol

PubMed ID: 35572691

Doi: 10.3389/fmicb.2022.882112

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Construction of a Large Size Human Immunoglobulin Heavy Chain Variable (VH) Domain Library, Isolation and Characterization of Novel Human Antibody VH Domains Targeting PD-L1 and CD22

Authors: Zehua Sun, Wei Li, John W Mellors, Rimas Orentas, Dimiter S Dimitrov

Journal: Front Immunol

PubMed ID: 35464476

Doi: 10.3389/fimmu.2022.869825

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-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone

Authors: Océane Tournière, James M Gahan, Henriette Busengdal, Natascha Bartsch, Fabian Rentzsch

Journal: Sci Adv

PubMed ID: 35442742

Doi: 10.1126/sciadv.abi7109

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Development of an Indirect ELISA Kit for Rapid Detection of Varicella-Zoster Virus Antibody by Glycoprotein E

Authors: Yan Niu, Aiping Wang, Jingming Zhou, Hongliang Liu, Yumei Chen, Peiyang Ding, Yanhua Qi, Chao Liang, Xifang Zhu, Gaiping Zhang

Journal: Front Microbiol

PubMed ID: 35572642

Doi: 10.3389/fmicb.2022.897752

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Design of Potent and Proteolytically Stable Biaryl-Stapled GLP-1R/GIPR Peptide Dual Agonists

Authors: Yifang Yang, Candy Lee, Reddy Rajasekhar Reddy, David J Huang, Weixia Zhong, Vân T B Nguyen-Tran, Weijun Shen, Qing Lin

Journal: ACS Chem Biol

PubMed ID: 35417146

Doi: 10.1021/acschembio.2c00175

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Reverse Electron Transfer by Respiratory Complex I Catalyzed in a Modular Proteoliposome System

Authors: John J Wright, Olivier Biner, Injae Chung, Nils Burger, Hannah R Bridges, Judy Hirst

Journal: J Am Chem Soc

PubMed ID: 35380814

Doi: 10.1021/jacs.2c00274

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Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery

Authors: Tian Zhou, Xinyi Zhu, Zhizhong Ye, Yong-Fei Wang, Chao Yao, Ning Xu, Mi Zhou, Jianyang Ma, Yuting Qin, Yiwei Shen, Yuanjia Tang, Zhihua Yin, Hong Xu, Yutong Zhang, Xiaoli Zang, Huihua Ding, Wanling Yang, Ya Guo, John B Harley, Bahram Namjou, Kenneth M Kaufman, Leah C Kottyan, Matthew T Weirauch, Guojun Hou, Nan Shen

Journal: Nat Commun

PubMed ID: 35388006

Doi: 10.1038/s41467-022-29514-y

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Distinct Stress-Dependent Signatures of Cellular and Extracellular tRNA-Derived Small RNAs

Authors: Guoping Li, Aidan C Manning, Alex Bagi, Xinyu Yang, Priyanka Gokulnath, Michail Spanos, Jonathan Howard, Patricia P Chan, Thadryan Sweeney, Robert Kitchen, Haobo Li, Brice D Laurent, Sary F Aranki, Maria I Kontaridis, Louise C Laurent, Kendall Van Keuren-Jensen, Jochen Muehlschlegel, Todd M Lowe, Saumya Das

Journal: Adv Sci (Weinh)

PubMed ID: 35373532

Doi: 10.1002/advs.202200829

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Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis

Authors: Yiqi Yang , Yixuan Lin , Minqi Wang , Kai Yuan , Qishan Wang , Pei Mu , Jingke Du , Zhifeng Yu , Shengbing Yang ， Kai Huang , Yugang Wang , Hanjun Li , Tingting Tang

Journal: Bone Res

PubMed ID: 35260560

Doi: doi.org/10.1038/s41413-022-00198-w

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DNA immunotherapy targeting BARF1 induces potent anti-tumor responses against Epstein-Barr-virus-associated carcinomas

Authors: Xizhou Zhu, Alfredo Perales-Puchalt, Krzysztof Wojtak, Ziyang Xu, Kun Yun, Pratik S Bhojnagarwala , Devivasha Bordoloi , Daniel H Park, Kevin Liaw, Mamadou A Bah, Paul M Lieberman , Ebony N Gary , Ami Patel , David B Weiner

Journal: Mol Ther Oncolytics

PubMed ID: 35071745

Doi: 10.1016/j.omto.2021.12.017

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RNF115 Inhibits the Post-ER Trafficking ofTLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination ofRAB1A and RAB13

Authors: Zhi-Dong Zhang , Hong-Xu Li , Hu Gan , Zhen Tang , Yu-Yao Guo , Shu-Qi Yao , Tianzi Liuyu , Bo Zhong , Dandan Lin

Journal: Adv Sci (Weinh)

PubMed ID: 35343654

Doi: doi.org/10.1002/advs.202105391

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SARS-CoV-2 variant B.1.1.7 caused HLA-A2 CD8 T cell epitope mutations for impaired cellular immune response.

Authors: Chanchan Xiao, Lipeng Mao , Zhigang Wang , Lijuan Gao , Guodong Zhu , Jun Su , Xiongfei Chen , Jun Yuan , Yutian Hu, Zhinan Yin, Jun Xie , Weiqing Ji , Haitao Niu , Feng Gao, Oscar Junhong Luo , Lianbo Xiao , Pengcheng Wang , Guobing Chen

Journal: iScience

PubMed ID: 35194575

Doi: 10.1016/j.isci.2022.103934

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TFPIisacoloniccryptreceptorforTcdBfromhypervirulentclade2C.difficile

Authors: Jianhua Luo , Qi Yang , Xiaofeng Zhang , Yuanyuan Zhang , Li Wan , Xiechao Zhan , Yao Zhou , Liuqing He , Danyang Li , Dazhi Jin , Ying Zhen , Jing Huang , Yanyan Li , Liang Tao

Journal: Cell

PubMed ID: 35303428

Doi: 10.1016/j.cell.2022.02.010

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Small molecule targeting CELF1 RNA-binding activity to control HSC activation and liver fibrosis

Authors: Yang Tan, Xueqing Sun, Yizhu Xu, Bingjie Tang, Shuaiqi Xu, Dong Lu, Yan Ye, Xiaomin Luo, Xu Diao, Fulong Li, Tianyi Wang, Jiayu Chen, Qiang Xu, Xingxin Wu

Journal: Nucleic Acids Res

PubMed ID: 35234905

Doi: 10.1093/nar/gkac139

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Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors

Authors: Jia Duan , Dan-Dan Shen , Tingting Zhao , Shimeng Guo , Xinheng He , Wanchao Yin , Peiyu Xu , Yujie Ji , Li-Nan Chen , Jinyu Liu , Huibing Zhang , Qiufeng Liu , Yi Shi , Xi Cheng , Hualiang Jiang , H Eric Xu , Yan Zhang , Xin Xie , Yi Jiang

Journal: Nat Commun

PubMed ID: 35292680

Doi: 10.1038/s41467-022-29072-3

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A scalable serology solution for profiling humoral immune responses to SARS-CoV-2 infection and vaccination

Authors: Karen Colwill, Yannick Galipeau, Matthew Stuible, Christian Gervais, Corey Arnold, Bhavisha Rathod, Kento T Abe, Jenny H Wang, Adrian Pasculescu, Mariam Maltseva, Lynda Rocheleau, Martin Pelchat, Mahya Fazel-Zarandi, Mariam Iskilova, Miriam Barrios-Rodiles, Linda Bennett, Kevin Yau, François Cholette, Christine Mesa, Angel X Li, Aimee Paterson, Michelle A Hladunewich, Pamela J Goodwin, Jeffrey L Wrana, Steven J Drews, Samira Mubareka, Allison J McGeer, John Kim, Marc-André Langlois, Anne-Claude Gingras, Yves Durocher

Journal: Clin Transl Immunology

PubMed ID: 35356067

Doi: 10.1002/cti2.1380

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Degenerate sequence-based CRISPR diagnostic for Crimean-Congo hemorrhagic fever virus

Authors: Hongzhao Li, Alexander Bello, Greg Smith, Dominic M S Kielich, James E Strong, Bradley S Pickering

Journal: PLoS Negl Trop Dis

PubMed ID: 35271569

Doi: 10.1371/journal.pntd.0010285

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The vaccinia-based Sementis Copenhagen Vector coronavirus disease 2019 vaccine induces broad and durable cellular and humoral immune responses

Authors: Preethi Eldi, Tamara H Cooper, Natalie A Prow, Liang Liu, Gary K Heinemann, Voueleng J Zhang, Abigail D Trinidad, Ruth Marian Guzman-Genuino, Peter Wulff, Leanne M Hobbs, Kerrilyn R Diener, John D Hayball

Journal: Immunol Cell Biol

PubMed ID: 35188985

Doi: 10.1111/imcb.12539

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YfiB: An Outer Membrane Protein Involved in the Virulence of

Authors: Tanuka Sen, Naresh K Verma

Journal: Microorganisms

PubMed ID: 35336228

Doi: 10.3390/microorganisms10030653

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Alpha-hydroxytropolones are noncompetitive inhibitors of human RNase H1 that bind to the active site and modulate substrate binding

Authors: Nathan L Ponzar, Razia Tajwar, Nicola Pozzi, John E Tavis

Journal: J Biol Chem

PubMed ID: 35247386

Doi: 10.1016/j.jbc.2022.101790

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Convergent epitope specificities, V gene usage and public clones elicited by primary exposure to SARS-CoV-2 variants

Authors: Noemia S Lima, Maryam Mukhamedova, Timothy S Johnston, Danielle A Wagner, Amy R Henry, Lingshu Wang, Eun Sung Yang, Yi Zhang, Kevina Birungi, Walker P Black, Sijy O'Dell, Stephen D Schmidt, Damee Moon, Cynthia G Lorang, Bingchun Zhao, Man Chen, Kristin L Boswell, Jesmine Roberts-Torres, Rachel L Davis, Lowrey Peyton, Sandeep R Narpala, Sarah O'Connell, Jennifer Wang, Alexander Schrager, Chloe Adrienna Talana, Kwanyee Leung, Wei Shi, Rawan Khashab, Asaf Biber, Tal Zilberman, Joshua Rhein, Sara Vetter, Afeefa Ahmed, Laura Novik, Alicia Widge, Ingelise Gordon, Mercy Guech, I-Ting Teng, Emily Phung, Tracy J Ruckwardt, Amarendra Pegu, John Misasi, Nicole A Doria-Rose, Martin Gaudinski, Richard A Koup, Peter D Kwong, Adrian B McDermott, Sharon Amit, Timothy W Schacker, Itzchak Levy, John R Mascola, Nancy J Sullivan, Chaim A Schramm, Daniel C Douek

Journal: biorxiv

PubMed ID: 35378757

Doi: 10.1101/2022.03.28.486152

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Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold

Authors: Jingjing Chen, Huixin He, Aihuan Wei, Yalei Li, Gang Cheng, Hui Qin, Hanyue Zhong, Hongchun Liu, Meiyu Geng, Aijun Shen, Youhong Hu

Journal: Eur J Med Chem

PubMed ID: 35395439

Doi: 10.1016/j.ejmech.2022.114259

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Rapid Exchange of Stably Bound Protein and DNA Cargo on a DNA Origami Receptor

Authors: James W P Brown, Rokiah G Alford, James C Walsh, Richard E Spinney, Stephanie Y Xu, Sophie Hertel, Jonathan F Berengut, Lisanne M Spenkelink, Antoine M van Oijen, Till Böcking, Richard G Morris, Lawrence K Lee

Journal: ACS Nano

PubMed ID: 35316035

Doi: 10.1021/acsnano.2c00699

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Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate

Authors: Ruixue Wang, Saori Suzuki, Johnathan D Guest, Brigitte Heller, Maricar Almeda, Alexander K Andrianov, Alexander Marin, Roy A Mariuzza, Zhen-Yong Keck, Steven K H Foung, Abdul S Yunus, Brian G Pierce, Eric A Toth, Alexander Ploss, Thomas R Fuerst

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35263223

Doi: 10.1073/pnas.2112008119

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In situ solid-state NMR study of antimicrobial peptide interactions with erythrocyte membranes

Authors: Kiran Kumar, Mathew Sebastiao, Alexandre A Arnold, Steve Bourgault, Dror E Warschawski, Isabelle Marcotte

Journal: Biophys J

PubMed ID: 35278426

Doi: 10.1016/j.bpj.2022.03.009

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Coupling cell growth and biochemical pathway induction in Saccharomyces cerevisiae for production of (+)-valencene and its chemical conversion to (+)-nootkatone

Authors: Ziling Ye, Yanglei Huang, Bin Shi, Zilei Xiang, Zhu Tian, Man Huang, Liangliang Wu, Zixin Deng, Kun Shen, Tiangang Liu

Journal: Metab Eng

PubMed ID: 35296429

Doi: 10.1016/j.ymben.2022.03.005

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Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH

Authors: Alena Stsiapanava, Chenrui Xu, Shunsuke Nishio, Ling Han, Nao Yamakawa, Marta Carroni, Kathryn Tunyasuvunakool, John Jumper, Daniele de Sanctis, Bin Wu, Luca Jovine

Journal: Nat Struct Mol Biol

PubMed ID: 35273390

Doi: 10.1038/s41594-022-00729-3

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MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity

Authors: Thilini S Munasinghe, Megan R Edwards, Sofiya Tsimbalyuk, Olivia A Vogel, Kate M Smith, Murray Stewart, Justin K Foster, Loretta A Bosence, David Aragão, Justin A Roby, Christopher F Basler, Jade K Forwood

Journal: Nat Commun

PubMed ID: 35338144

Doi: 10.1038/s41467-022-28851-2

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Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer

Authors: Andrea Lopez, Denis E Reyna, Nadege Gitego, Felix Kopp, Hua Zhou, Miguel A Miranda-Roman, Lars Ulrik Nordstrøm, Swathi-Rao Narayanagari, Ping Chi, Eduardo Vilar, Aristotelis Tsirigos, Evripidis Gavathiotis

Journal: Nat Commun

PubMed ID: 35256598

Doi: 10.1038/s41467-022-28741-7

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The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist

Authors: Christian Berg, Michael J Wedemeyer, Motiejus Melynis, Roman R Schlimgen, Lasse H Hansen, Jon Våbenø, Francis C Peterson, Brian F Volkman, Mette M Rosenkilde, Hans R Lüttichau

Journal: PLoS Pathog

PubMed ID: 35271688

Doi: 10.1371/journal.ppat.1010355

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Diagnostic Host Gene Expression Analysis by Quantitative Reverse Transcription Loop-Mediated Isothermal Amplification to Discriminate between Bacterial and Viral Infections

Authors: Melissa C Remmel, Sabrina M Coyle, Mark W Eshoo, Timothy E Sweeney, David C Rawling

Journal: Clin Chem

PubMed ID: 35134876

Doi: 10.1093/clinchem/hvab275

Products & Services: Mammalian Expression

Zymomonas mobilis ZM4 Utilizes an NADP-Dependent Acetaldehyde Dehydrogenase To Produce Acetate

Authors: Magdalena M Felczak, Michaela A TerAvest

Journal: J Bacteriol

PubMed ID: 35258321

Doi: 10.1128/jb.00563-21

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Structural basis of an endocytic checkpoint that primes the AP2 clathrin adaptor for cargo internalization

Authors: Edward A Partlow, Kevin S Cannon, Gunther Hollopeter, Richard W Baker

Journal: Nat Struct Mol Biol

PubMed ID: 35347313

Doi: 10.1038/s41594-022-00749-z

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A simple reverse genetics method to generate recombinant coronaviruses

Authors: Julien Mélade, Géraldine Piorkowski, Franck Touret, Toscane Fourié, Jean-Sélim Driouich, Maxime Cochin, Hawa Sophia Bouzidi, Bruno Coutard, Antoine Nougairède, Xavier de Lamballerie

Journal: EMBO Rep

PubMed ID: 35239997

Doi: 10.15252/embr.202153820

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Circ_0060531 knockdown ameliorates IL-22-induced keratinocyte damage by binding to miR-330-5p to decrease GAB1 expression

Authors: Quan Shi, Jing Luo, Weiming Chen, Qi He, Jianwen Long, Bo Zhang

Journal: Autoimmunity

PubMed ID: 35293807

Doi: 10.1080/08916934.2022.2037127

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Regulation of paternal 5mC oxidation and H3K9me2 asymmetry by ERK1/2 in mouse zygotes

Authors: Baobao Chen, Mingtian Deng, Meng-Hao Pan, Shao-Chen Sun, Honglin Liu

Journal: Cell Biosci

PubMed ID: 35255956

Doi: 10.1186/s13578-022-00758-x

Products & Services: Proteins, Expression, Isolation and Analysis

RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin

Authors: Tal Keren-Kaplan, Amra Sarić, Saikat Ghosh, Chad D Williamson, Rui Jia, Yan Li, Juan S Bonifacino

Journal: Nat Commun

PubMed ID: 35314674

Doi: 10.1038/s41467-022-28952-y

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Age-dependent formation of TMEM106B amyloid filaments in human brains

Authors: Manuel Schweighauser, Diana Arseni, Mehtap Bacioglu, Melissa Huang, Sofia Lövestam, Yang Shi, Yang Yang, Wenjuan Zhang, Abhay Kotecha, Holly J Garringer, Ruben Vidal, Grace I Hallinan, Kathy L Newell, Airi Tarutani, Shigeo Murayama, Masayuki Miyazaki, Yuko Saito, Mari Yoshida, Kazuko Hasegawa, Tammaryn Lashley, Tamas Revesz, Gabor G Kovacs, John van Swieten, Masaki Takao, Masato Hasegawa, Bernardino Ghetti, Maria Grazia Spillantini, Benjamin Ryskeldi-Falcon, Alexey G Murzin, Michel Goedert, Sjors H W Scheres

Journal: Nature

PubMed ID: 35344985

Doi: 10.1038/s41586-022-04650-z

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A peroxisomal heterodimeric enzyme is involved in benzaldehyde synthesis in plants

Authors: Xing-Qi Huang, Renqiuguo Li, Jianxin Fu, Natalia Dudareva

Journal: Nat Commun

PubMed ID: 35292635

Doi: 10.1038/s41467-022-28978-2

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Performance of Chimeric Antigens in Serological Screening for Chagas Disease in Blood Banks

Authors: Emily Ferreira Dos Santos, Ângelo Antônio Oliveira Silva, Natália Erdens Maron Freitas, Leonardo Maia Leony, Ramona Tavares Daltro, Carlos Antônio de Souza Teles Santos, Maria da Conceição Chagas de Almeida, Fernando Luiz Vieira de Araújo, Paola Alejandra Fiorani Celedon, Marco Aurélio Krieger, Nilson Ivo Tonin Zanchin, Mitermayer Galvão Dos Reis, Fred Luciano Neves Santos

Journal: Front Med (Lausanne)

PubMed ID: 35330587

Doi: 10.3389/fmed.2022.852864

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A novel series of putative Brugia malayi histone demethylase inhibitors as potential anti-filarial drugs

Authors: Tamara Kreiss, Tyler Eck, Brittany Hart, Sreedhar Tummalapalli, David Rotella, John Siekierka

Journal: PLoS Negl Trop Dis

PubMed ID: 35294431

Doi: 10.1371/journal.pntd.0010216

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The protective effects of butorphanol tartrate against homocysteine-induced blood-brain barrier dysfunction

Authors: Sufeng Shen, Jiandong Wang, Qingyuan Zhao, Qiangfu Hu

Journal: Bioengineered

PubMed ID: 35245993

Doi: 10.1080/21655979.2022.2037953

Products & Services: Gene Synthesis

Pull-Down Into Active Inclusion Bodies and Their Application in the Detection of (Poly)-Phosphates and Metal-Ions

Authors: Eva Hrabarova, Martina Belkova, Romana Koszagova, Jozef Nahalka

Journal: Front Bioeng Biotechnol

PubMed ID: 35299638

Doi: 10.3389/fbioe.2022.833192

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Sequence-specific destabilization of azurin by tetramethylguanidinium-dipeptide ionic liquids

Authors: Roshani Patel, Austin K Clark, Gabriella DeStefano, Isabella DeStefano, Hunter Gogoj, Erin Gray, Aashka Y Patel, Joshua T Hauner, Gregory A Caputo, Timothy D Vaden

Journal: Biochem Biophys Rep

PubMed ID: 35280523

Doi: 10.1016/j.bbrep.2022.101242

Products & Services: Bacterial Expression

Rituximab-treated patients with lymphoma develop strong CD8 T-cell responses following COVID-19 vaccination

Authors: Jon Riise, Saskia Meyer, Isaac Blaas, Adity Chopra, Trung T Tran, Marina Delic-Sarac, Malu Lian Hestdalen, Ellen Brodin, Even Holth Rustad, Ke-Zheng Dai, John Torgils Vaage, Lise Sofie Haug Nissen-Meyer, Fredrik Sund, Karin F Wader, Anne T Bjornevik, Peter A Meyer, Gro O Nygaard, Marton König, Sigbjørn Smeland, Fridtjof Lund-Johansen, Johanna Olweus, Arne Kolstad

Journal: Br J Haematol

PubMed ID: 35254660

Doi: 10.1111/bjh.18149

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Polycystin-1 regulates cell proliferation and migration through AKT/mTORC2 pathway in a human craniosynostosis cell model

Authors: Maria A Katsianou, Kostas A Papavassiliou, Antonios N Gargalionis, George Agrogiannis, Penelope Korkolopoulou, Dimitrios Panagopoulos, Marios S Themistocleous, Christina Piperi, Efthimia K Basdra, Athanasios G Papavassiliou

Journal: J Cell Mol Med

PubMed ID: 35285136

Doi: 10.1111/jcmm.17266

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Modified vaccinia Ankara expressing EEHV1A glycoprotein B elicits humoral and cell-mediated immune responses in mice

Authors: Taylor Pursell, Jennifer L Spencer Clinton, Jie Tan, Rongsheng Peng, Paul D Ling

Journal: PLoS ONE

PubMed ID: 35312707

Doi: 10.1371/journal.pone.0265424

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Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity

Authors: Dapeng Li, Simon Brackenridge, Lucy C Walters, Olivia Swanson, Karl Harlos, Daniel Rozbesky, Derek W Cain, Kevin Wiehe, Richard M Scearce, Maggie Barr, Zekun Mu, Robert Parks, Max Quastel, Robert J Edwards, Yunfei Wang, Wes Rountree, Kevin O Saunders, Guido Ferrari, Persephone Borrow, E Yvonne Jones, S Munir Alam, Mihai L Azoitei, Geraldine M Gillespie, Andrew J McMichael, Barton F Haynes

Journal: Commun Biol

PubMed ID: 35347236

Doi: 10.1038/s42003-022-03183-5

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RPA-Cas12aDS: A visual and fast molecular diagnostics platform based on RPA-CRISPR-Cas12a method for infectious bursal disease virus detection

Authors: Su-Ya Zheng, Li-Li Ma, Xiao-Li Wang, Li-Xin Lu, Sun-Ting Ma, Bin Xu, Wei Ouyang

Journal: J Virol Methods

PubMed ID: 35288230

Doi: 10.1016/j.jviromet.2022.114523

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Production of indole by Corynebacterium glutamicum microbial cell factories for flavor and fragrance applications

Authors: Melanie Mindt, Arman Beyraghdar Kashkooli, Maria Suarez-Diez, Lenny Ferrer, Tatjana Jilg, Dirk Bosch, Vitor Martins Dos Santos, Volker F Wendisch, Katarina Cankar

Journal: Microb Cell Fact

PubMed ID: 35331232

Doi: 10.1186/s12934-022-01771-y

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Targeted Codelivery of Prodigiosin and Simvastatin Using Smart BioMOF: Functionalization by Recombinant Anti-VEGFR1 scFv

Authors: Somayyeh Mirzaeinia, Sedighe Zeinali, Nediljko Budisa, Hamid Reza Karbalaei-Heidari

Journal: Front Bioeng Biotechnol

PubMed ID: 35402395

Doi: 10.3389/fbioe.2022.866275

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Computational Design and Biological Evaluation of Analogs of Lupin Peptide P5 Endowed with Dual PCSK9/HMG-CoAR Inhibiting Activity

Authors: Carmen Lammi, Enrico M A Fassi, Jianqiang Li, Martina Bartolomei, Giulia Benigno, Gabriella Roda, Anna Arnoldi, Giovanni Grazioso

Journal: Pharmaceutics

PubMed ID: 35336039

Doi: 10.3390/pharmaceutics14030665

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Phosphoproteome Analysis Identifies a Synaptotagmin-1-Associated Complex Involved in Ischemic Neuron Injury

Authors: Wei Jiang, Pei Zhang, Peng Yang, Na Kang, Junqiang Liu, Yilixiati Aihemaiti, Haijun Tu

Journal: Mol Cell Proteomics

PubMed ID: 35257887

Doi: 10.1016/j.mcpro.2022.100222

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A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6

Authors: Devon Jeltema, Jihong Wang, Juan Cai, Nathan Kelley, Zhe Yang, Yuan He

Journal: J Immunol

PubMed ID: 35354613

Doi: 10.4049/jimmunol.2101154

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Development of spirulina for the manufacture and oral delivery of protein therapeutics

Authors: Benjamin W Jester, Hui Zhao, Mesfin Gewe, Thomas Adame, Lisa Perruzza, David T Bolick, Jan Agosti, Nhi Khuong, Rolf Kuestner, Caitlin Gamble, Kendra Cruickshank, Jeremy Ferrara, Rachelle Lim, Troy Paddock, Colin Brady, Stacey Ertel, Miaohua Zhang, Alex Pollock, Jamie Lee, Jian Xiong, Michael Tasch, Tracy Saveria, David Doughty, Jacob Marshall, Damian Carrieri, Lauren Goetsch, Jason Dang, Nathaniel Sanjaya, David Fletcher, Anissa Martinez, Bryce Kadis, Kristjan Sigmar, Esha Afreen, Tammy Nguyen, Amanda Randolph, Alexandria Taber, Ashley Krzeszowski, Brittney Robinett, David B Volkin, Fabio Grassi, Richard Guerrant, Ryo Takeuchi, Brian Finrow, Craig Behnke, James Roberts

Journal: Nat Biotechnol

PubMed ID: 35314813

Doi: 10.1038/s41587-022-01249-7

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Efficacy and Safety of Heterologous Booster Vaccination after Ad5-nCoV (CanSino Biologics) Vaccine: A Preliminary Descriptive Study

Authors: José Francisco Muñoz-Valle, Gabriela Athziri Sánchez-Zuno, Mónica Guadalupe Matuz-Flores, Cristian Oswaldo Hernández-Ramírez, Saúl Alberto Díaz-Pérez, Christian Johana Baños-Hernández, Francisco Javier Turrubiates-Hernández, Alejandra Natali Vega-Magaña, Jorge Hernández-Bello

Journal: Vaccines (Basel)

PubMed ID: 35335032

Doi: 10.3390/vaccines10030400

Spectrum of Phenotypic, Genetic, and Functional Characteristics in Patients With Epilepsy With Pathogenic Variants

Authors: Niklas Schwarz, Simone Seiffert, Manuela Pendziwiat, Annika Verena Rademacher, Tobias Brünger, Ulrike B S Hedrich, Paul B Augustijn, Hartmut Baier, Allan Bayat, Francesca Bisulli, Russell J Buono, Ben Zeev Bruria, Michael G Doyle, Renzo Guerrini, Gali Heimer, Michele Iacomino, Hugh Kearney, Karl Martin Klein, Ioanna Kousiappa, Wolfram S Kunz, Holger Lerche, Laura Licchetta, Ebba Lohmann, Raffaella Minardi, Marie McDonald, Sarah Montgomery, Lejla Mulahasanovic, Renske Oegema, Barel Ortal, Savvas S Papacostas, Francesca Ragona, Tiziana Granata, Phillip S Reif, Felix Rosenow, Annick Rothschild, Paolo Scudieri, Pasquale Striano, Paolo Tinuper, George A Tanteles, Annalisa Vetro, Felix Zahnert, Ethan M Goldberg, Federico Zara, Dennis Lal, Patrick May, Hiltrud Muhle, Ingo Helbig, Yvonne Weber

Journal: Neurology

PubMed ID: 35314505

Doi: 10.1212/WNL.0000000000200660

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Site-specific nanobody-oligonucleotide conjugation for super-resolution imaging

Authors: Laura Teodori, Marjan Omer, Anders Märcher, Mads K Skaanning, Veronica L Andersen, Jesper S Nielsen, Emil Oldenburg, Yuchen Lin, Kurt V Gothelf, Jørgen Kjems

Journal: J Biol Methods

PubMed ID: 35510035

Doi: 10.14440/jbm.2022.381

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Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity

Authors: Lauren B Rodda, Peter A Morawski, Kurt B Pruner, Mitchell L Fahning, Christian A Howard, Nicholas Franko, Jennifer Logue, Julie Eggenberger, Caleb Stokes, Inah Golez, Malika Hale, Michael Gale, Helen Y Chu, Daniel J Campbell, Marion Pepper

Journal: Cell

PubMed ID: 35413241

Doi: 10.1016/j.cell.2022.03.018

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Complement C3a Enhances the Phagocytic Activity of B Cells Through C3aR in a Fish

Authors: Zi-You Ma, Jia-Xin Liang, Wen-Shuo Li, Yuan Sun, Chang-Song Wu, Ya-Zhen Hu, Jun Li, Yong-An Zhang, Xu-Jie Zhang

Journal: Front Immunol

PubMed ID: 35386704

Doi: 10.3389/fimmu.2022.873982

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