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Dynamic of anti-spike receptor binding domain (RBD) levels and short-term adverse events following a heterologous booster dose of BNT162b2 after two doses of CoronaVac in Thai health care workers

Authors: Amonrphat Kitro, Wachiranun Sirikul, Weeraya Thongkum, Suthinee Soponpong, Umpa Yasamut, Wuttipat Kiratipaisarl, Apiradee Kosai, Watchara Kasinrerk, Chatchai Tayapiwatana, Kriengkrai Srithanaviboonchai

Journal: Vaccine

PubMed ID: 35430106

Doi: 10.1016/j.vaccine.2022.04.020

Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit

Authors: Nicholas K Hurlburt, Leah J Homad, Irika Sinha, Madeleine F Jennewein, Anna J MacCamy, Yu-Hsin Wan, Jim Boonyaratanakornkit, Anton M Sholukh, Abigail M Jackson, Panpan Zhou, Dennis R Burton, Raiees Andrabi, Gabriel Ozorowski, Andrew B Ward, Leonidas Stamatatos, Marie Pancera, Andrew T McGuire

Journal: Commun Biol

PubMed ID: 35411021

Doi: 10.1038/s42003-022-03262-7

Products & Services: Recombinant Proteins

Correction to "Febuxostat Prevents the Cytotoxicity of Propofol in Brain Endothelial Cells"

Authors: Jianli Hao, Weiqing Zhang, Rui Tong, Zeqing Huang

Journal: ACS Omega

PubMed ID: 35465124

Doi: 10.1021/acsomega.2c01716

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Recombinant Limosilactobacillus (Lactobacillus) delivering nanobodies against Clostridium perfringens NetB and alpha toxin confers potential protection from necrotic enteritis

Authors: Dharanesh Gangaiah, Valerie Ryan, Daphne Van Hoesel, Shrinivasrao P Mane, Enid T Mckinley, Nallakannu Lakshmanan, Nandakumar D Reddy, Edward Dolk, Arvind Kumar

Journal: Microbiologyopen

PubMed ID: 35478283

Doi: 10.1002/mbo3.1270

Products & Services: Proteins, Expression, Isolation and Analysis

NEAT1: Culprit lncRNA linking PIG-C, MSLN, and CD80 in triple-negative breast cancer

Authors: Nada H Hussein, Reda A Eissa, M de Bruyn, Hend M El Tayebi

Journal: Life Sci

PubMed ID: 35378140

Doi: 10.1016/j.lfs.2022.120523

Products & Services: Proteins, Expression, Isolation and Analysis

CCPG1 involved in corneal infection

Authors: Li-Mei Wang, Xiao-Meng Chen, Hai-Jing Yan, Shu Yan, Xiao-Yan Sun, Da-Wei Zhang, Hua Yang, Dan-Li Lu, Cheng-Ye Che

Journal: Int J Ophthalmol

PubMed ID: 35450172

Doi: 10.18240/ijo.2022.04.03

Products & Services: Proteins, Expression, Isolation and Analysis

Dataset of high-throughput ligand screening against the RNA Packaging Signals regulating Hepatitis B Virus nucleocapsid formation

Authors: Fardokht Abulwerdi, Farzad Fatehi, Iain W Manfield, Stuart F J Le Grice, John S Schneekloth, Reidun Twarock, Peter G Stockley, Nikesh Patel

Journal: Data Brief

PubMed ID: 35516001

Doi: 10.1016/j.dib.2022.108206

Products & Services: Proteins, Expression, Isolation and Analysis

Cloning and Organelle Expression of Bamboo Mitochondrial Complex I Subunits Nad1, Nad2, Nad4, and Nad5 in the Yeast

Authors: Hsieh-Chin Tsai, Cheng-Hung Hsieh, Ching-Wen Hsu, Yau-Heiu Hsu, Lee-Feng Chien

Journal: Int J Mol Sci

PubMed ID: 35409414

Doi: 10.3390/ijms23074054

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LPS Response Is Impaired by Urban Fine Particulate Matter

Authors: Natália de Souza Xavier Costa, Gabriel Ribeiro Júnior, Adair Aparecida Dos Santos Alemany, Luciano Belotti, Marcela Frota Cavalcante, Susan Ribeiro, Mariana Matera Veras, Esper Georges Kallás, Paulo Hilário Nascimento Saldiva, Marisa Dolhnikoff, Luiz Fernando Ferraz da Silva

Journal: Int J Mol Sci

PubMed ID: 35409273

Doi: 10.3390/ijms23073913

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Identification and characterization of novel endolysins targeting Gardnerella vaginalis biofilms to treat bacterial vaginosis

Authors: Sara Arroyo-Moreno, Matthew Cummings, David B Corcoran, Aidan Coffey, Ronan R McCarthy

Journal: NPJ Biofilms Microbiomes

PubMed ID: 35440653

Doi: 10.1038/s41522-022-00285-0

Products & Services: Proteins, Expression, Isolation and Analysis

Ethyl Gallate Dual-Targeting PTPN6 and PPARγ Shows Anti-Diabetic and Anti-Obese Effects

Authors: Dohee Ahn, Jinsoo Kim, Gibeom Nam, Xiaodi Zhao, Jihee Kwon, Ji Young Hwang, Jae Kwan Kim, Sun-Young Yoon, Sang J Chung

Journal: Int J Mol Sci

PubMed ID: 35563411

Doi: 10.3390/ijms23095020

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MicroRNA-217 modulates pancreatic cancer progression via targeting ATAD2

Authors: Madhuri Dutta, Biswajit Das, Debasish Mohapatra, Padmanava Behera, Shantibhusan Senapati, Anasuya Roychowdhury

Journal: Life Sci

PubMed ID: 35504332

Doi: 10.1016/j.lfs.2022.120592

Products & Services: Recombinant Proteins

Peptide Permeation across a Phosphocholine Membrane: An Atomically Detailed Mechanism Determined through Simulations and Supported by Experimentation

Authors: Alfredo E Cardenas, Chad I Drexler, Rachel Nechushtai, Ron Mittler, Assaf Friedler, Lauren J Webb, Ron Elber

Journal: J Phys Chem B

PubMed ID: 35388695

Doi: 10.1021/acs.jpcb.1c10966

Products & Services: Peptide Synthesis

A GH115 α-glucuronidase structure reveals dimerization-mediated substrate binding and a proton wire potentially important for catalysis

Authors: Casper Wilkens, Marlene Vuillemin, Bo Pilgaard, Igor Polikarpov, Jens Preben Morth

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35503213

Doi: 10.1107/S2059798322003527

Products & Services: Plasmid DNA Preparation

Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs

Authors: Helena Tossavainen, Hasan Uğurlu, Mikael Karjalainen, Maarit Hellman, Lina Antenucci, Riku Fagerlund, Kalle Saksela, Perttu Permi

Journal: Structure

PubMed ID: 35390274

Doi: 10.1016/j.str.2022.03.006

Products & Services: Recombinant Antibody Expression

Impact of Moderna mRNA-1273 Booster Vaccine on Fully Vaccinated High-Risk Chronic Dialysis Patients after Loss of Humoral Response

Authors: Sammy Patyna, Timon Eckes, Benjamin F Koch, Stephan Sudowe, Anke Oftring, Niko Kohmer, Holger F Rabenau, Sandra Ciesek, Despina Avaniadi, Rahel Steiner, Ingeborg A Hauser, Josef M Pfeilschifter, Christoph Betz

Journal: Vaccines (Basel)

PubMed ID: 35455334

Doi: 10.3390/vaccines10040585

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BRAF Modulates Lipid Use and Accumulation

Authors: Jacqueline A Turner, Emily L Paton, Robert Van Gulick, Davide Stefanoni, Francesca Cendali, Julie Reisz, Richard P Tobin, Martin McCarter, Angelo D'Alessandro, Raul M Torres, William A Robinson, Kasey L Couts, Isabel R Schlaepfer

Journal: Cancers (Basel)

PubMed ID: 35565240

Doi: 10.3390/cancers14092110

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production of pederin by labrenzin pathway expansion

Authors: Dina Kačar, Carmen Schleissner, Librada M Cañedo, Pilar Rodríguez, Fernando de la Calle, Carmen Cuevas, Beatriz Galán, José Luis García

Journal: Metab Eng Commun

PubMed ID: 35517715

Doi: 10.1016/j.mec.2022.e00198

Products & Services: PCR Cloning and Subcloning

NADPH-Cytochrome P450 Reductase Mediates the Fatty Acid Desaturation of ω3 and ω6 Desaturases from

Authors: Mingxuan Wang, Jing Li, Wenjie Cong, Jianguo Zhang

Journal: Curr Issues Mol Biol

PubMed ID: 35678654

Doi: 10.3390/cimb44050125

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Simultaneous Measurement of IgM and IgG Antibodies to SARS-CoV-2 Spike, RBD, and Nucleocapsid Multiplexed in a Single Assay on the xMAP INTELLIFLEX DR-SE Flow Analyzer

Authors: Andrew Cameron, Jessica L Bohrhunter, Claire A Porterfield, Rupinder Mangat, Michael H Karasick, Zachary Pearson, Stephen Angeloni, Nicole D Pecora

Journal: Microbiol Spectr

PubMed ID: 35389244

Doi: 10.1128/spectrum.02507-21

Products & Services: Proteins, Expression, Isolation and Analysis

Safety and Immunogenicity of a Booster Vaccination by CoronaVac or BNT162b2 in Previously Two-Dose Inactivated Virus Vaccinated Individuals with Negative Neutralizing Antibody

Authors: Kristi Tsz-Wan Lai, Emilie Yuen-Ting Lai Wan Loong, Terry Ling-Hiu Fung, Luke Wing-Pan Luk, Chor-Chiu Lau, Jonpaul Sze-Tsing Zee, Edmond Shiu-Kwan Ma, Bone Siu-Fai Tang

Journal: Vaccines (Basel)

PubMed ID: 35455305

Doi: 10.3390/vaccines10040556

Products & Services: Proteins, Expression, Isolation and Analysis

Immunoreactivity of humanized single-chain variable fragment against its functional epitope on domain 1 of CD147

Authors: Nutjeera Intasai, Kuntalee Rangnoi, Montarop Yamabhai, Thanathat Pamonsupornwichit, Weeraya Thongkum, Umpa Yasamut, Koollawat Chupradit, Nuchjira Takheaw, Piyarat Nimmanpipug, Chatchai Tayapiwatana

Journal: Sci Rep

PubMed ID: 35468972

Doi: 10.1038/s41598-022-10657-3

Products & Services: Bacterial Expression

A genetic toolkit and gene switches to limit Mycoplasma growth for biosafety applications

Authors: Alicia Broto, Erika Gaspari, Samuel Miravet-Verde, Vitor A P Martins Dos Santos, Mark Isalan

Journal: Nat Commun

PubMed ID: 35393441

Doi: 10.1038/s41467-022-29574-0

Products & Services: Mutagenesis Services

pH-Responsive Polymer Nanoparticles for Efficient Delivery of Cas9 Ribonucleoprotein With or Without Donor DNA

Authors: Ruosen Xie, Xiuxiu Wang, Yuyuan Wang, Mingzhou Ye, Yi Zhao, Brian S Yandell, Shaoqin Gong

Journal: Adv Mater

PubMed ID: 35119139

Doi: 10.1002/adma.202110618

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Antimicrobial and Immunomodulatory Effects of Selected Chemokine and Antimicrobial Peptide on Cytokine Profile during Typhimurium Infection in Mouse

Authors: Astrid Tuxpan-Pérez, Marco Antonio Ibarra-Valencia, Blanca Elisa Estrada, Herlinda Clement, Ligia Luz Corrales-García, Gerardo Pavel Espino-Solis, Gerardo Corzo

Journal: Antibiotics (Basel)

PubMed ID: 35625251

Doi: 10.3390/antibiotics11050607

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Bma-LAD-2, an Intestinal Cell Adhesion Protein, as a Potential Therapeutic Target for Lymphatic Filariasis

Authors: Alexander F Flynn, Rebekah T Taylor, Marzena E Pazgier, Sasisekhar Bennuru, Alyssa R Lindrose, Spencer L Sterling, C Paul Morris, Brynna I Gleeson, Tim K Maugel, Thomas B Nutman, Edward Mitre

Journal: MBio

PubMed ID: 35475643

Doi: 10.1128/mbio.03742-21

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Multifunctional polyphenol-based silk hydrogel alleviate soxidative stress and enhances endogenous regeneration of osteochondral defects.

Authors: Wei Zhang 1 2 3, Yanan Zhang 1, Xiaolong Li 1, Zhicheng Cao 1 4, Qingyun Mo 1, Renwang Sheng 1, Chen Ling 1 4, Jiayu Chi 1, Qingqiang Yao 4 3, Jialin Chen 1 2 3, Hongmei Wang 1

Journal: Mater Today Bio

PubMed ID: 35469254

Doi: 10.1016/j.mtbio.2022.100251

Products & Services: Recombinant Proteins

A polyesterase from the Antarctic bacterium Moraxella sp degrades highly crystalline synthetic polymers

Authors: Efstratios Nikolaivits, George Taxeidis, Christina Gkountela, Stamatina Vouyiouka, Veselin Maslak, Jasmina Nikodinovic-Runic, Evangelos Topakas

Journal: J Hazard Mater

PubMed ID: 35452981

Doi: 10.1016/j.jhazmat.2022.128900

Products & Services: Bacterial Expression

Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry

Authors: Tanaya Bagga, Nikhil Kumar Tulsian, Yu Keung Mok, R Manjunatha Kini, J Sivaraman

Journal: Cell Mol Life Sci

PubMed ID: 35397701

Doi: 10.1007/s00018-022-04245-x

Products & Services: Plasmid DNA Preparation

Impaired Humoral Immunity with Concomitant Preserved T Cell Reactivity in IBD Patients on Treatment with Infliximab 6 Month after Vaccination with the SARS-CoV-2 mRNA Vaccine BNT162b2: A Pilot Study

Authors: Richard Vollenberg, Phil-Robin Tepasse, Eva Lorentzen, Tobias Max Nowacki

Journal: J Pers Med

PubMed ID: 35629116

Doi: 10.3390/jpm12050694

SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 T cells

Authors: Anastasia A Minervina, Mikhail V Pogorelyy, Allison M Kirk, Jeremy Chase Crawford, E Kaitlynn Allen, Ching-Heng Chou, Robert C Mettelman, Kim J Allison, Chun-Yang Lin, David C Brice, Xun Zhu, Kasi Vegesana, Gang Wu, Sanchit Trivedi, Pratibha Kottapalli, Daniel Darnell, Suzanne McNeely, Scott R Olsen, Stacey Schultz-Cherry, Jeremie H Estepp, Maureen A McGargill, Joshua Wolf, Paul G Thomas

Journal: Nat Immunol

PubMed ID: 35383307

Doi: 10.1038/s41590-022-01184-4

Products & Services: GenParts™ DNA Fragments

A Single-Domain TCR-like Antibody Selective for the Qa-1/Qdm Peptide Complex Enhances Tumoricidal Activity of NK Cells via Blocking the NKG2A Immune Checkpoint

Authors: Soroush Ghaffari, Katherine Upchurch-Ange, Susanne Gimlin, Trivendra Tripathi, Marjolein Sluijter, Jim Middelburg, Thorbald van Hall, Jon Weidanz

Journal: J Immunol

PubMed ID: 35418467

Doi: 10.4049/jimmunol.2100790

Products & Services: Proteins, Expression, Isolation and Analysis

Structural insight into UV-B-activated UVR8 bound to COP1

Authors: Yidong Wang, Lixia Wang, Zeyuan Guan, Hongfei Chang, Ling Ma, Cuicui Shen, Liang Qiu, Junjie Yan, Delin Zhang, Jian Li, Xing Wang Deng, Ping Yin

Journal: Sci Adv

PubMed ID: 35442727

Doi: 10.1126/sciadv.abn3337

Products & Services: Proteins, Expression, Isolation and Analysis

Humoral immunity against SARS-CoV-2 variants including omicron in solid organ transplant recipients after three doses of a COVID-19 mRNA vaccine

Authors: Kapil K Saharia, Jennifer S Husson, Silke V Niederhaus, Thierry Iraguha, Stephanie V Avila, Youngchae J Yoo, Nancy M Hardy, Xiaoxuan Fan, Destiny Omili, Alice Crane, Amber Carrier, Wen Y Xie, Erica Vander Mause, Kim Hankey, Sherri Bauman, Patricia Lesho, Heather D Mannuel, Ashish Ahuja, Minu Mathew, James Avruch, John Baddley, Olga Goloubeva, Kirti Shetty, Saurabh Dahiya, Aaron P Rapoport, Tim Luetkens, Djordje Atanackovic

Journal: Clin Transl Immunology

PubMed ID: 35505864

Doi: 10.1002/cti2.1391

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Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured Cu supplants entropically favoured Zn to form Cu clusters under physiological conditions

Authors: Matthew R Mehlenbacher, Rahma Elsiesy, Rabina Lakha, Rhiza Lyne E Villones, Marina Orman, Christina L Vizcarra, Gabriele Meloni, Dean E Wilcox, Rachel N Austin

Journal: Chem Sci

PubMed ID: 35655557

Doi: 10.1039/d2sc00676f

Products & Services: Codon Optimization

Tripartite motif containing 63, regulated by E26 transformation specific variant 4, facilitates the thyroid carcinoma progression and the AKT, p38, and ERK signaling pathways

Authors: Jingni He, Ying Zhang, Baiyu Yao, Lidong Wang, Zhong Tian

Journal: Mol Cell Endocrinol

PubMed ID: 35390449

Doi: 10.1016/j.mce.2022.111639

Products & Services: Gene Synthesis

Melatonin Mediated Differential Regulation of Drought Tolerance in Sensitive and Tolerant Varieties of Upland Cotton (

Authors: Laha Supriya, Pullaiahgari Durgeshwar, Mehanathan Muthamilarasan, Gudipalli Padmaja

Journal: Front Plant Sci

PubMed ID: 35444676

Doi: 10.3389/fpls.2022.821353

Products & Services: Proteins, Expression, Isolation and Analysis

Nutrient sensitive protein -GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis

Authors: Shama Parween, Thilina T Alawathugoda, Ashok D Prabakaran, S Thameem Dheen, Randall H Morse, Bright Starling Emerald, Suraiya A Ansari

Journal: Life Sci Alliance

PubMed ID: 35470239

Doi: 10.26508/lsa.202201385

Products & Services: Proteins, Expression, Isolation and Analysis

Peptide of Infective Larval Extract That Harnesses Growth of Human Hepatoma Cells

Authors: Pichet Ruenchit, Onrapak Reamtong, Ladawan Khowawisetsut, Poom Adisakwattana, Monrat Chulanetra, Kasem Kulkeaw, Wanpen Chaicumpa

Journal: Front Cell Infect Microbiol

PubMed ID: 35558100

Doi: 10.3389/fcimb.2022.882608

Products & Services: Peptide Synthesis

Restoration of Sarco/Endoplasmic Reticulum Ca-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca Depletion

Authors: Wen Zhang, Fanghua Ye, Nan Pang, Miriam Kessi, Juan Xiong, Shimeng Chen, Jing Peng, Li Yang, Fei Yin

Journal: Front Pharmacol

PubMed ID: 35517826

Doi: 10.3389/fphar.2022.877175

Products & Services: Mutagenesis Services

BDSF Is a Degradation-Prone Quorum-Sensing Signal Detected by the Histidine Kinase RpfC of pv

Authors: Xiu-Qi Tian, Yao Wu, Zhen Cai, Wei Qian

Journal: Appl Environ Microbiol

PubMed ID: 35369702

Doi: 10.1128/aem.00031-22

Products & Services: Recombinant Proteins

Multiple-Allele MHC Class II Epitope Engineering by a Molecular Dynamics-Based Evolution Protocol

Authors: Rodrigo Ochoa, Victoria Alves Santos Lunardelli, Daniela Santoro Rosa, Alessandro Laio, Pilar Cossio

Journal: Front Immunol

PubMed ID: 35572587

Doi: 10.3389/fimmu.2022.862851

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Gain-of-function and loss-of-function GABRB3 variants lead to distinct clinical phenotypes in patients with developmental and epileptic encephalopathies

Authors: Nathan L Absalom, Vivian W Y Liao, Katrine M H Johannesen, Elena Gardella, Julia Jacobs, Gaetan Lesca, Zeynep Gokce-Samar, Alexis Arzimanoglou, Shimriet Zeidler, Pasquale Striano, Pierre Meyer, Ira Benkel-Herrenbrueck, Inger-Lise Mero, Jutta Rummel, Mary Chebib, Rikke S Møller, Philip K Ahring

Journal: Nat Commun

PubMed ID: 35383156

Doi: 10.1038/s41467-022-29280-x

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A conserved module regulates receptor kinase signalling in immunity and development

Authors: Thomas A DeFalco, Pauline Anne, Sean R James, Andrew C Willoughby, Florian Schwanke, Oliver Johanndrees, Yasmine Genolet, Paul Derbyshire, Qian Wang, Surbhi Rana, Anne-Marie Pullen, Frank L H Menke, Cyril Zipfel, Christian S Hardtke, Zachary L Nimchuk

Journal: Nat Plants

PubMed ID: 35422079

Doi: 10.1038/s41477-022-01134-w

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The Readthrough Isoform AQP4ex Is Constitutively Phosphorylated in the Perivascular Astrocyte Endfeet of Human Brain

Authors: Roberta Pati, Claudia Palazzo, Onofrio Valente, Pasqua Abbrescia, Raffaella Messina, Nicoletta Concetta Surdo, Konstantinos Lefkimmiatis, Francesco Signorelli, Grazia Paola Nicchia, Antonio Frigeri

Journal: Biomolecules

PubMed ID: 35625560

Doi: 10.3390/biom12050633

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Estimating the Neutralizing Effect and Titer Correlation of Semi-Quantitative Anti-SARS-CoV-2 Antibody Immunoassays

Authors: Beomki Lee, Jae-Hoon Ko, Jiho Park, Hee-Won Moon, Jin Yang Baek, Sunhee Jung, Hee-Young Lim, Kyung-Chang Kim, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Hee Jae Huh, Chi Ryang Chung, Yae-Jean Kim, Eun-Jeong Joo, Eun-Suk Kang, Kyong Ran Peck

Journal: Front Cell Infect Microbiol

PubMed ID: 35493733

Doi: 10.3389/fcimb.2022.822599

Engineered RBCs Encapsulating Antigen Induce Multi-Modal Antigen-Specific Tolerance and Protect Against Type 1 Diabetes

Authors: Colin J Raposo, Judith D Cserny, Gloria Serena, Jonathan N Chow, Patricia Cho, Hanyang Liu, David Kotler, Armon Sharei, Howard Bernstein, Shinu John

Journal: Front Immunol

PubMed ID: 35444659

Doi: 10.3389/fimmu.2022.869669

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Role of the anillin-like protein in growth of Cryptococcus neoformans at human host temperature

Authors: Congyue A Peng, Sophie Altamirano, Namrata Paladugu, Logan P Crowe, Inas F Aboobakar, Srikripa Chandrasekaran, Lukasz Kozubowski

Journal: Fungal Genet Biol

PubMed ID: 35472450

Doi: 10.1016/j.fgb.2022.103697

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Efficient exploration of terpenoid biosynthetic gene clusters in filamentous fungi

Authors: Yujie Yuan, Shu Cheng, Guangkai Bian, Pan Yan, Zhengning Ma, Wen Dai, Rong Chen, Shuai Fu, Huiwen Huang, Haoming Chi, Yousheng Cai, Zixin Deng & Tiangang Liu

Journal: Nature Catalysis

Doi: 10.1038/s41929-022-00762-x

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Indirubin-3’-monoxime acts as proteasome inhibitor:Therapeutic application in multiple myeloma

Authors: Zhen Yu , Xiaojing Wei , Lanting Liu , Hao Sun , Teng Fang , Lu Wang , Ying Li , Weiwei Sui , Kefei Wang , Yi He , Yaozhong Zhao , Wenyang Huang , Gang An , Fancui Meng , Changjiang Huang , Tengteng Yu , Kenneth C Anderson , Tao Cheng , Lugui Qiu , Mu Hao

Journal: EBioMedicine

PubMed ID: 35344764

Doi: 10.1016/j.ebiom.2022.103950

Products & Services: Proteins, Expression, Isolation and Analysis

Specification of CNS macrophage subsets occurs postnatally in defined niches

Authors: Takahiro Masuda, Lukas Amann, Gianni Monaco, Roman Sankowski, Ori Staszewski, Martin Krueger, Francesca Del Gaudio, Liqun He, Neil Paterson, Elisa Nent, Francisco Fernández-Klett, Ayato Yamasaki, Maximilian Frosch, Maximilian Fliegauf, Lance Fredrick Pahutan Bosch, Hatice Ulupinar, Nora Hagemeyer, Dietmar Schreiner, Cayce Dorrier, Makoto Tsuda, Claudia Grothe, Anne Joutel, Richard Daneman, Christer Betsholtz, Urban Lendahl, Klaus-Peter Knobeloch, Tim Lämmermann, Josef Priller, Katrin Kierdorf, Marco Prinz

Journal: Nature

PubMed ID: 35444273

Doi: 10.1038/s41586-022-04596-2

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Real meat and plant-based meat analogues have different in vitro protein digestibility properties

Authors: Yunting Xie, Linlin Cai, Di Zhao, Hui Liu, Xinglian Xu, Guanghong Zhou, Chunbao Li

Journal: Food Chem

PubMed ID: 35413556

Doi: 10.1016/j.foodchem.2022.132917

Products & Services: Proteins, Expression, Isolation and Analysis

Alternative splicing of an exitron determines the subnuclear localization of the Arabidopsis DNA glycosylase MBD4L under heat stress

Authors: Nicolás Miguel Cecchini , José Roberto Torres , Ignacio Lescano López, Santiago Cobo, Florencia Nota, María Elena Alvarez

Journal: Plant J

PubMed ID: 35061303

Doi: 10.1111/tpj.15675

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Premetazoan Origin of Neuropeptide Signaling

Authors: Luis Alfonso Yañez-Guerra, Daniel Thiel, Gáspár Jékely

Journal: Mol Biol Evol

PubMed ID: 35277960

Doi: 10.1093/molbev/msac051

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Structural insights into the peptide selectivity and activation of human neuromedin U receptors

Authors: Chongzhao You , Yumu Zhang , Peiyu Xu , Sijie Huang , Wanchao Yin, H Eric Xu , Yi Jiang

Journal: Nat Commun

PubMed ID: 35440625

Doi: 10.1038/s41467-022-29683-w

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Characterization of Calcium-Dependent Protein Kinase 2A, a Potential Drug Target Against Cryptosporidiosis

Authors: Fanfan Shu, Yu Li, Wenlun Chu, Xuehua Chen, Ziding Zhang, Yaqiong Guo, Yaoyu Feng, Lihua Xiao, Na Li

Journal: Front Microbiol

PubMed ID: 35558125

Doi: 10.3389/fmicb.2022.883674

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Hypericin nanoparticles for self-illuminated photodynamic cytotoxicity based on bioluminescence resonance energy transfer

Authors: Hao-Han Yu, Qiu-Ping Deng, Qing-Hua Zheng, Yi Wang, Jian Shen, Jia-Hong Zhou

Journal: Int J Pharm

PubMed ID: 35427744

Doi: 10.1016/j.ijpharm.2022.121738

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Artemether inhibits proliferation, invasion and migration of hepatocellular carcinoma cells via targeting of CYP2J2

Authors: Xionglin Zhu, Mei Yang, Zhiling Song, Guangbing Yao, Qifeng Shi

Journal: Oncol Lett

PubMed ID: 35464300

Doi: 10.3892/ol.2022.13300

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Secretes Small RNA to Target Host and Retard Plant Floral Transition During Infection

Authors: Bo-Sen Zhang, Ying-Chao Li, Hui-Shan Guo, Jian-Hua Zhao

Journal: Front Plant Sci

PubMed ID: 35519822

Doi: 10.3389/fpls.2022.847086

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A Novel Multi-Epitope Edible Vaccine Candidate for Newcastle Disease Virus: Approach

Authors: Atena Mozafari, Jafar Amani, Shahla Shahsavandi, Ali Hatef Salmanian

Journal: Iran J Biotechnol

PubMed ID: 36337069

Doi: 10.30498/ijb.2022.298822.3119

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Family 1 Glycosyltransferase UGT706F8 from Selectively Catalyzes the Synthesis of Silibinin 7--β-d-Glucoside

Authors: Gonzalo N Bidart, Natalia Putkaradze, Folmer Fredslund, Christian Kjeldsen, Ander Garralda Ruiz, Jens Ø Duus, David Teze, Ditte H Welner

Journal: ACS Sustain Chem Eng

PubMed ID: 35493695

Doi: 10.1021/acssuschemeng.1c07593

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Novel insight into the transformation of peptides and potential benefits in brown fermented goat milk by mesoporous magnetic dispersive solid phase extraction-based peptidomics

Authors: Wei Jia, An Du, Zibian Fan, Lin Shi

Journal: Food Chem

PubMed ID: 35504074

Doi: 10.1016/j.foodchem.2022.133110

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Development of Antifungal Peptides against Cryptococcus neoformans; Leveraging Knowledge about the Mutant Susceptibility for Lead Compound Development

Authors: Robert J Tancer, Yina Wang, Siddhi Pawar, Chaoyang Xue, Gregory R Wiedman

Journal: Microbiol Spectr

PubMed ID: 35377230

Doi: 10.1128/spectrum.00439-22

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The C-Terminal Transmembrane Domain of Cowpea Mild Mottle Virus TGBp2 Is Critical for Plasmodesmata Localization and for Its Interaction With TGBp1 and TGBp3

Authors: Chong Jiang, Shiqi Shan, Yue Huang, Chenyang Mao, Hehong Zhang, Yanjun Li, Jianping Chen, Zhongyan Wei, Zongtao Sun

Journal: Front Microbiol

PubMed ID: 35495691

Doi: 10.3389/fmicb.2022.860695

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The Copper Resistome of Group B Streptococcus Reveals Insight into the Genetic Basis of Cellular Survival during Metal Ion Stress

Authors: Kelvin G K Goh, Matthew J Sullivan, Glen C Ulett

Journal: J Bacteriol

PubMed ID: 35404113

Doi: 10.1128/jb.00068-22

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N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system

Authors: Feng Jiang, Jiawei Shen, Jiaxuan Cheng, Xia Wang, Jianguo Yang, Ningning Li, Ning Gao, Qi Jin

Journal: Sci Adv

PubMed ID: 35486720

Doi: 10.1126/sciadv.abm2343

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MIMAS: microfluidic platform in tandem with MALDI mass spectrometry for protein quantification from small cell ensembles

Authors: Jorvani Cruz Villarreal, Rory Kruithoff, Ana Egatz-Gomez, Paul D Coleman, Robert Ros, Todd R Sandrin, Alexandra Ros

Journal: Anal Bioanal Chem

PubMed ID: 35385983

Doi: 10.1007/s00216-022-04038-y

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Multi-Omics Analysis Reveals That Synergistically Regulates SGAs and Fruit Development

Authors: Hao Guo, Mengdi Mao, Yuan Deng, Lisong Sun, Ridong Chen, Peng Cao, Jun Lai, Yueran Zhang, Chao Wang, Chun Li, Yiran Li, Qunhang Bai, Tingting Tan, Jun Yang, Shouchuang Wang

Journal: Front Plant Sci

PubMed ID: 35463452

Doi: 10.3389/fpls.2022.860577

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The structure of Phocaeicola vulgatus sialic acid acetylesterase

Authors: Hannah Scott, Gideon J Davies, Zachary Armstrong

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35503212

Doi: 10.1107/S2059798322003357

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Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Authors: Chao Wang, Li Fan, Rabia R Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T Grinberg, William W Seeley, Bruce L Miller, Sue-Ann Mok, Jason E Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Gan

Journal: Nat Commun

PubMed ID: 35413950

Doi: 10.1038/s41467-022-29552-6

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Mechanism of RNA polymerase I selection by transcription factor UAF

Authors: Florence Baudin, Brice Murciano, Herman K H Fung, Simon A Fromm, Simone Mattei, Julia Mahamid, Christoph W Müller

Journal: Sci Adv

PubMed ID: 35442737

Doi: 10.1126/sciadv.abn5725

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A Novel Homozygous Variant Leading to Type-1 Familial Glucocorticoid Deficiency

Authors: Idris Mohammed, Basma Haris, Khalid Hussain

Journal: J Endocr Soc

PubMed ID: 35506146

Doi: 10.1210/jendso/bvac058

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Expanding the Editing Window of Cytidine Base Editors With the Rad51 DNA-Binding Domain in Rice

Authors: Chunjie Wei, Hao Liu, Wenwen Wang, Pengyu Luo, Qiuling Chen, Rou Li, Chong Wang, José Ramón Botella, Hui Zhang

Journal: Front Plant Sci

PubMed ID: 35548314

Doi: 10.3389/fpls.2022.865848

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Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24

Authors: Lingguang Yang, Laixing Zhang, Peipei Yin, Hao Ding, Yu Xiao, Jianwei Zeng, Wenhe Wang, Huan Zhou, Qisheng Wang, Yi Zhang, Zeliang Chen, Maojun Yang, Yue Feng

Journal: Nat Commun

PubMed ID: 35411005

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Cellular Immune Response in Patients Immunized with Three Vaccine Doses of Different Vaccination Schemes Authorized by the Chilean Ministry of Health in January 2022

Authors: Paz Beatriz Tabilo Valenzuela, Gabriela Flores Balter, Gustavo Saint-Pierre Contreras, Daniel Conei Valencia, Catalina Moreno Calderón, Constanza Bohle Venegas, Marcia Guajardo Rivera, Francisco Silva Ojeda, Maria Jesus Vial Covarrubias

Journal: Life (Basel)

PubMed ID: 35455024

Doi: 10.3390/life12040534

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A Novel Immunochromatographic Strip Based on Latex Microspheres for the Rapid Detection of North American-Type Porcine Reproductive and Respiratory Syndrome Virus

Authors: Wansheng Li, Minhua Li, Hongliang Zhang, Chao Li, Hu Xu, Bangjun Gong, Jun Fu, Zhenyang Guo, Jinmei Peng, Guohui Zhou, Zhijun Tian, Qian Wang

Journal: Front Microbiol

PubMed ID: 35572691

Doi: 10.3389/fmicb.2022.882112

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SNX27-Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling

Authors: Boris Simonetti, Qian Guo, Manuel Giménez-Andrés, Kai-En Chen, Edmund R R Moody, Ashley J Evans, Mintu Chandra, Chris M Danson, Tom A Williams, Brett M Collins, Peter J Cullen

Journal: PLoS Biol

PubMed ID: 35417450

Doi: 10.1371/journal.pbio.3001601

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Construction of a Large Size Human Immunoglobulin Heavy Chain Variable (VH) Domain Library, Isolation and Characterization of Novel Human Antibody VH Domains Targeting PD-L1 and CD22

Authors: Zehua Sun, Wei Li, John W Mellors, Rimas Orentas, Dimiter S Dimitrov

Journal: Front Immunol

PubMed ID: 35464476

Doi: 10.3389/fimmu.2022.869825

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Suppression of lysosomal-associated protein transmembrane 5 ameliorates cardiac function and inflammatory response by inhibiting the nuclear factor-kappa B (NF-κB) pathway after myocardial infarction in mice

Authors: Zhanchun Song, Xiaozeng Wang, Lianqi He, Liang Chen, Zhichao Ren, Siyu Song

Journal: Exp Anim

PubMed ID: 35491099

Doi: 10.1538/expanim.22-0008

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Reverse Electron Transfer by Respiratory Complex I Catalyzed in a Modular Proteoliposome System

Authors: John J Wright, Olivier Biner, Injae Chung, Nils Burger, Hannah R Bridges, Judy Hirst

Journal: J Am Chem Soc

PubMed ID: 35380814

Doi: 10.1021/jacs.2c00274

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-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone

Authors: Océane Tournière, James M Gahan, Henriette Busengdal, Natascha Bartsch, Fabian Rentzsch

Journal: Sci Adv

PubMed ID: 35442742

Doi: 10.1126/sciadv.abi7109

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Characterization of BLUF-photoreceptors present in Acinetobacter nosocomialis

Authors: Inés Abatedaga, Bárbara Perez Mora, Marisel Tuttobene, Gabriela Müller, Daiana Biancotti, Claudio D Borsarelli, Lorena Valle, Maria A Mussi

Journal: PLoS ONE

PubMed ID: 35442978

Doi: 10.1371/journal.pone.0254291

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Design of Potent and Proteolytically Stable Biaryl-Stapled GLP-1R/GIPR Peptide Dual Agonists

Authors: Yifang Yang, Candy Lee, Reddy Rajasekhar Reddy, David J Huang, Weixia Zhong, Vân T B Nguyen-Tran, Weijun Shen, Qing Lin

Journal: ACS Chem Biol

PubMed ID: 35417146

Doi: 10.1021/acschembio.2c00175

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Dynamics of Neutralizing Antibody and T-Cell Responses to SARS-CoV-2 and Variants of Concern after Primary Immunization with CoronaVac and Booster with BNT162b2 or ChAdOx1 in Health Care Workers

Authors: Watsamon Jantarabenjakul, Pimpayao Sodsai, Napaporn Chantasrisawad, Anusara Jitsatja, Sasiprapa Ninwattana, Nattakarn Thippamom, Vichaya Ruenjaiman, Chee Wah Tan, Rakchanok Pradit, Jiratchaya Sophonphan, Supaporn Wacharapluesadee, Lin-Fa Wang, Thanyawee Puthanakit, Nattiya Hirankarn, Opass Putcharoen

Journal: Vaccines (Basel)

PubMed ID: 35632395

Doi: 10.3390/vaccines10050639

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Type XX Collagen Is Elevated in Circulation of Patients with Solid Tumors

Authors: Jeppe Thorlacius-Ussing, Christina Jensen, Emilie A Madsen, Neel I Nissen, Tina Manon-Jensen, Inna M Chen, Julia S Johansen, Hadi M H Diab, Lars N Jørgensen, Morten A Karsdal, Nicholas Willumsen

Journal: Int J Mol Sci

PubMed ID: 35456962

Doi: 10.3390/ijms23084144

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Inhibitor of DNA binding 2 (ID2) regulates the expression of developmental genes and tumorigenesis in ewing sarcoma

Authors: Stacia L Koppenhafer, Kelli L Goss, Ellen Voigt, Emma Croushore, William W Terry, Jason Ostergaard, Peter M Gordon, David J Gordon

Journal: Oncogene

PubMed ID: 35422476

Doi: 10.1038/s41388-022-02310-0

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Immunization With Recombinant Y75B8A8 Partially Protects Local Crossbred Female Goats From Infection

Authors: Xiaowei Tian, Mingmin Lu, Yongqian Bu, Yang Zhang, Kalibixiati Aimulajiang, Meng Liang, Charles Li, Ruofeng Yan, Lixin Xu, Xiaokai Song, Xiangrui Li

Journal: Front Vet Sci

PubMed ID: 35445096

Doi: 10.3389/fvets.2022.765700

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Development of an Indirect ELISA Kit for Rapid Detection of Varicella-Zoster Virus Antibody by Glycoprotein E

Authors: Yan Niu, Aiping Wang, Jingming Zhou, Hongliang Liu, Yumei Chen, Peiyang Ding, Yanhua Qi, Chao Liang, Xifang Zhu, Gaiping Zhang

Journal: Front Microbiol

PubMed ID: 35572642

Doi: 10.3389/fmicb.2022.897752

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The miR-532-E2F1 feedback loop contributes to gastric cancer progression

Authors: Shanting Gao, Xiaomin Bu, Yongyue Gao, Zengtao Bao, Wenchao Shi, Lipeng Luan, Huiyu Chen, Baoming Zhang, Qingshui Tian, Wenxian Guan, Liuqing Yang

Journal: Cell Death Dis

PubMed ID: 35440106

Doi: 10.1038/s41419-022-04832-7

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is a 3D matrix-specific mediator of mechanosensitive stem cell lineage commitment

Authors: Jieung Baek, Paola A Lopez, Sangmin Lee, Taek-Soo Kim, Sanjay Kumar, David V Schaffer

Journal: Sci Adv

PubMed ID: 35427160

Doi: 10.1126/sciadv.abm4646

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A single point mutation in the Plasmodium falciparum 3'-5' exonuclease does not alter piperaquine susceptibility

Authors: Nonlawat Boonyalai, Kirakarn Kirativanich, Chatchadaporn Thamnurak, Chantida Praditpol, Brian A Vesely, Mariusz Wojnarski, John S Griesenbeck, Norman C Waters

Journal: Malar J

PubMed ID: 35459163

Doi: 10.1186/s12936-022-04148-z

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Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery

Authors: Tian Zhou, Xinyi Zhu, Zhizhong Ye, Yong-Fei Wang, Chao Yao, Ning Xu, Mi Zhou, Jianyang Ma, Yuting Qin, Yiwei Shen, Yuanjia Tang, Zhihua Yin, Hong Xu, Yutong Zhang, Xiaoli Zang, Huihua Ding, Wanling Yang, Ya Guo, John B Harley, Bahram Namjou, Kenneth M Kaufman, Leah C Kottyan, Matthew T Weirauch, Guojun Hou, Nan Shen

Journal: Nat Commun

PubMed ID: 35388006

Doi: 10.1038/s41467-022-29514-y

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Distinct Stress-Dependent Signatures of Cellular and Extracellular tRNA-Derived Small RNAs

Authors: Guoping Li, Aidan C Manning, Alex Bagi, Xinyu Yang, Priyanka Gokulnath, Michail Spanos, Jonathan Howard, Patricia P Chan, Thadryan Sweeney, Robert Kitchen, Haobo Li, Brice D Laurent, Sary F Aranki, Maria I Kontaridis, Louise C Laurent, Kendall Van Keuren-Jensen, Jochen Muehlschlegel, Todd M Lowe, Saumya Das

Journal: Adv Sci (Weinh)

PubMed ID: 35373532

Doi: 10.1002/advs.202200829

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Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis

Authors: Yiqi Yang , Yixuan Lin , Minqi Wang , Kai Yuan , Qishan Wang , Pei Mu , Jingke Du , Zhifeng Yu , Shengbing Yang ， Kai Huang , Yugang Wang , Hanjun Li , Tingting Tang

Journal: Bone Res

PubMed ID: 35260560

Doi: doi.org/10.1038/s41413-022-00198-w

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DNA immunotherapy targeting BARF1 induces potent anti-tumor responses against Epstein-Barr-virus-associated carcinomas

Authors: Xizhou Zhu, Alfredo Perales-Puchalt, Krzysztof Wojtak, Ziyang Xu, Kun Yun, Pratik S Bhojnagarwala , Devivasha Bordoloi , Daniel H Park, Kevin Liaw, Mamadou A Bah, Paul M Lieberman , Ebony N Gary , Ami Patel , David B Weiner

Journal: Mol Ther Oncolytics

PubMed ID: 35071745

Doi: 10.1016/j.omto.2021.12.017

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RNF115 Inhibits the Post-ER Trafficking ofTLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination ofRAB1A and RAB13

Authors: Zhi-Dong Zhang , Hong-Xu Li , Hu Gan , Zhen Tang , Yu-Yao Guo , Shu-Qi Yao , Tianzi Liuyu , Bo Zhong , Dandan Lin

Journal: Adv Sci (Weinh)

PubMed ID: 35343654

Doi: doi.org/10.1002/advs.202105391

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SARS-CoV-2 variant B.1.1.7 caused HLA-A2 CD8 T cell epitope mutations for impaired cellular immune response.

Authors: Chanchan Xiao, Lipeng Mao , Zhigang Wang , Lijuan Gao , Guodong Zhu , Jun Su , Xiongfei Chen , Jun Yuan , Yutian Hu, Zhinan Yin, Jun Xie , Weiqing Ji , Haitao Niu , Feng Gao, Oscar Junhong Luo , Lianbo Xiao , Pengcheng Wang , Guobing Chen

Journal: iScience

PubMed ID: 35194575

Doi: 10.1016/j.isci.2022.103934

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TFPIisacoloniccryptreceptorforTcdBfromhypervirulentclade2C.difficile

Authors: Jianhua Luo , Qi Yang , Xiaofeng Zhang , Yuanyuan Zhang , Li Wan , Xiechao Zhan , Yao Zhou , Liuqing He , Danyang Li , Dazhi Jin , Ying Zhen , Jing Huang , Yanyan Li , Liang Tao

Journal: Cell

PubMed ID: 35303428

Doi: 10.1016/j.cell.2022.02.010

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Small molecule targeting CELF1 RNA-binding activity to control HSC activation and liver fibrosis

Authors: Yang Tan, Xueqing Sun, Yizhu Xu, Bingjie Tang, Shuaiqi Xu, Dong Lu, Yan Ye, Xiaomin Luo, Xu Diao, Fulong Li, Tianyi Wang, Jiayu Chen, Qiang Xu, Xingxin Wu

Journal: Nucleic Acids Res

PubMed ID: 35234905

Doi: 10.1093/nar/gkac139

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Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors

Authors: Jia Duan , Dan-Dan Shen , Tingting Zhao , Shimeng Guo , Xinheng He , Wanchao Yin , Peiyu Xu , Yujie Ji , Li-Nan Chen , Jinyu Liu , Huibing Zhang , Qiufeng Liu , Yi Shi , Xi Cheng , Hualiang Jiang , H Eric Xu , Yan Zhang , Xin Xie , Yi Jiang

Journal: Nat Commun

PubMed ID: 35292680

Doi: 10.1038/s41467-022-29072-3

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