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Exploration of Pyrrolysyl-tRNA Synthetase Activity in Yeast

Authors: Jessica T Stieglitz, Priyanka Lahiri, Matthew I Stout, James A Van Deventer

Journal: ACS Synth Biol

PubMed ID: 35417129

Doi: 10.1021/acssynbio.2c00001

Products & Services: Proteins, Expression, Isolation and Analysis

β-arrestin2 mediates the hippocampal dopaminergic system in autistic mouse through the ERK signaling pathway

Authors: Yu Zhou, Yamei Liu, Qingyu Peng, Feng Li, Fuxue Chen

Journal: Behav Brain Res

PubMed ID: 35398487

Doi: 10.1016/j.bbr.2022.113888

Products & Services: Proteins, Expression, Isolation and Analysis

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA

Authors: Beverly Y Mok, Anna V Kotrys, Aditya Raguram, Tony P Huang, Vamsi K Mootha, David R Liu

Journal: Nat Biotechnol

PubMed ID: 35379961

Doi: 10.1038/s41587-022-01256-8

Products & Services: Mammalian Expression

PPARγ phase separates with RXRα at PPREs to regulate target gene expression

Authors: Zhean Li, Lingling Luo, Wenxia Yu, Ping Li, Danfeng Ou, Jia Liu, Hanhui Ma, Qinhu Sun, Aibin Liang, Cheng Huang, Tian Chi, Xingxu Huang, Yu Zhang

Journal: Cell Discov

PubMed ID: 35473936

Doi: 10.1038/s41421-022-00388-0

Products & Services: GenParts™ DNA Fragments

Ultrasensitive CRISPR/Cas12a-Driven SERS Biosensor for On-Site Nucleic Acid Detection and Its Application to Milk Authenticity Testing

Authors: Ruiyuan Pan, Jianghua Liu, Panxue Wang, Di Wu, Jian Chen, Yongning Wu, Guoliang Li

Journal: J Agric Food Chem

PubMed ID: 35380812

Doi: 10.1021/acs.jafc.1c08262

Products & Services: Custom DNA/RNA Oligos

OCC-1D regulates Wnt signaling pathway: potential role of long noncoding RNA in colorectal cancer

Authors: Fatemeh Yousefi, Hadi Najafi, Mehrdad Behmanesh, Bahram M Soltani

Journal: Mol Biol Rep

PubMed ID: 35397713

Doi: 10.1007/s11033-021-07110-5

Products & Services: Custom Vector Construction

Expression of the K74 Killer Toxin from Saccharomyces paradoxus Is Modulated by the Toxin-Encoding M74 Double-Stranded RNA 5' Untranslated Terminal Region

Authors: Nieves Rodriguez-Cousiño, Pilar Gómez, Rosa Esteban

Journal: Appl Environ Microbiol

PubMed ID: 35389250

Doi: 10.1128/aem.02030-21

Products & Services: Proteins, Expression, Isolation and Analysis

Role of Chitinase-3-like Protein 1 in Cardioprotection and Angiogenesis by Post-Infarction Exercise Training

Authors: Zhuo Li, Fangnan Wu, Lei Xi, Zhenjun Tian

Journal: Biomedicines

PubMed ID: 35625766

Doi: 10.3390/biomedicines10051028

Products & Services: Proteins, Expression, Isolation and Analysis

Measles-based Zika vaccine induces long-term immunity and requires NS1 antibodies to protect the female reproductive tract

Authors: Drishya Kurup, Christoph Wirblich, Rachael Lambert, Leila Zabihi Diba, Benjamin E Leiby, Matthias J Schnell

Journal: npj Vaccines

PubMed ID: 35440656

Doi: 10.1038/s41541-022-00464-2

Products & Services: Gene Synthesis

Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate

Authors: Akihiro Honda, Shotaro Kamata, Makoto Akahane, Yui Machida, Kie Uchii, Yui Shiiyama, Yuki Habu, Saeka Miyawaki, Chihiro Kaneko, Takuji Oyama, Isao Ishii

Journal: Int J Mol Sci

PubMed ID: 35563117

Doi: 10.3390/ijms23094726

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CXCR7 Agonist TC14012 Improves Angiogenic Function of Endothelial Progenitor Cells via Activating Akt/eNOS Pathway and Promotes Ischemic Angiogenesis in Diabetic Limb Ischemia

Authors: Kai Wang, Shiyue Sun, Guigui Zhang, Zixian Lu, Hui Chen, Xia Fan, Chunjie Gu, Xiaohong Pan, Qian Lin, Oscar Chen, Lu Cai, Xiaozhen Dai, Xiao Wang, Chaosheng Lu, Xiaoqing Yan, Yi Tan

Journal: Cardiovasc Drugs Ther

PubMed ID: 35471717

Doi: 10.1007/s10557-022-07337-9

Products & Services: Gene Synthesis

Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements

Authors: Caridad Miró-Pina, Olivia Charmant, Takayuki Kawaguchi, Daniel Holoch, Audrey Michaud, Isadora Cohen, Adeline Humbert, Yan Jaszczyszyn, Guillaume Chevreux, Laurence Del Maestro, Slimane Ait-Si-Ali, Olivier Arnaiz, Raphaël Margueron, Sandra Duharcourt

Journal: Dev Cell

PubMed ID: 35429435

Doi: 10.1016/j.devcel.2022.03.014

Products & Services: Proteins, Expression, Isolation and Analysis

Rapid and sensitive detection of African swine fever virus in pork using recombinase aided amplification combined with QDMs-based test strip

Authors: Xiaoyun Wen, Qingyun Xie, Jiahao Li, Yanrui Pei, Yun Bai, Fei Liu, Haiying Cui, Guoqing Shao, Zhixin Feng

Journal: Anal Bioanal Chem

PubMed ID: 35380231

Doi: 10.1007/s00216-022-04030-6

Products & Services: Gene Synthesis

A simple method to determine changes in the affinity between HisF and HisH in the Imidazole Glycerol Phosphate Synthase heterodimer

Authors: Vitor M Almeida, J Patrick Loria, Sandro R Marana

Journal: PLoS ONE

PubMed ID: 35452497

Doi: 10.1371/journal.pone.0267536

Products & Services: Recombinant Antibody Expression

Silencing of Chitin-Binding Protein with PYPV-Rich Domain Impairs Cuticle and Wing Development in the Asian Citrus Psyllid,

Authors: Haizhong Yu, Long Yi, Zhanjun Lu

Journal: Insects

PubMed ID: 35447795

Doi: 10.3390/insects13040353

Products & Services: Proteins, Expression, Isolation and Analysis

Asymmetric Pericentrosomal CD133 Endosomes Induce the Unequal Autophagic Activity During Cytokinesis in CD133-Positive Human Neuroblastoma Cells

Authors: Hideki Izumi, Yuanyuan Li, Michio Yasunami, Seiji Sato, Takao Mae, Yasuhiko Kaneko, Akira Nakagawara

Journal: Stem Cells

PubMed ID: 35284915

Doi: 10.1093/stmcls/sxac007

Products & Services: DNA Sequencing

A phenotypic signature that identifies neoantigen-reactive T cells in fresh human lung cancers

Authors: Ken-Ichi Hanada, Chihao Zhao, Raul Gil-Hoyos, Jared J Gartner, Christopher Chow-Parmer, Frank J Lowery, Sri Krishna, Todd D Prickett, Scott Kivitz, Maria R Parkhurst, Nathan Wong, Zachary Rae, Michael C Kelly, Stephanie L Goff, Paul F Robbins, Steven A Rosenberg, James C Yang

Journal: Cancer Cell

PubMed ID: 35452604

Doi: 10.1016/j.ccell.2022.03.012

Products & Services: Neoantigen Peptide Service

Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis

Authors: Takafumi Kato, Giorgia Radicioni, Micah J Papanikolas, Georgi V Stoychev, Matthew R Markovetz, Kazuhiro Aoki, Melody Porterfield, Kenichi Okuda, Selene M Barbosa Cardenas, Rodney C Gilmore, Cameron B Morrison, Camille Ehre, Kimberlie A Burns, Kristen K White, Tara A Brennan, Henry P Goodell, Holly Thacker, Henry T Loznev, Lawrence J Forsberg, Takahide Nagase, Michael Rubinstein, Scott H Randell, Michael Tiemeyer, David B Hill, Mehmet Kesimer, Wanda K O'Neal, Stephen T Ballard, Ronit Freeman, Brian Button, Richard C Boucher

Journal: Sci Adv

PubMed ID: 35363522

Doi: 10.1126/sciadv.abm9718

Products & Services: Plasmid DNA Preparation

Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells

Authors: Kareem A Heslop, Pieter Burger, Christiana Kappler, Ashish K Solanki, Monika Gooz, Yuri K Peterson, Catherine Mills, Thomas Benton, Stephen A Duncan, Patrick M Woster, Eduardo N Maldonado

Journal: Biomed Pharmacother

PubMed ID: 35447542

Doi: 10.1016/j.biopha.2022.112928

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The development of a candidate of desensitization vaccines against Der f 2 nearly without IgE-binding activity

Authors: Xiao-Jing Ling, Chen Pan, Ling-Xiao Tan, Ying Zhu, Yu-Xing Yang, Xiao-Fei Zeng, Jin-Lyu Sun, Ji-Fu Wei, Chen Lu

Journal: Immunobiology

PubMed ID: 35580444

Doi: 10.1016/j.imbio.2022.152217

Products & Services: Proteins, Expression, Isolation and Analysis

The Model for Mucolipidosis Type IV

Authors: Claire Y Allan, Paul R Fisher

Journal: Front Cell Dev Biol

PubMed ID: 35493081

Doi: 10.3389/fcell.2022.741967

Products & Services: Proteins, Expression, Isolation and Analysis

A novel multifunctional anti-PD-L1-CD16a-IL15 induces potent cancer cell killing in PD-L1-positive tumour cells

Authors: Yumei Li, Lingjun Wu, Yueying Liu, Siwen Ma, Biyi Huang, Xianjing Feng, Hui Wang

Journal: Transl Oncol

PubMed ID: 35477065

Doi: 10.1016/j.tranon.2022.101424

Products & Services: Mammalian Expression

Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action

Authors: Johannes Gubat, Karthik Selvaraju, Linda Sjöstrand, Dhananjay Kumar Singh, Maria V Turkina, Bernhard Schmierer, Pierre Sabatier, Roman A Zubarev, Stig Linder, Pádraig D'Arcy

Journal: Front Oncol

PubMed ID: 35530310

Doi: 10.3389/fonc.2022.852980

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Combination of resolvin E1 and lipoxin A4 promotes the resolution of pulpitis by inhibiting NF-κB activation through upregulating sirtuin 7 in dental pulp fibroblasts

Authors: Xiaochen Liu, Chunmeng Wang, Liping Pang, Liangliang Pan, Qi Zhang

Journal: Cell Prolif

PubMed ID: 35411569

Doi: 10.1111/cpr.13227

Products & Services: Recombinant Proteins

The Paget's disease of bone risk gene PML is a negative regulator of osteoclast differentiation and bone resorption

Authors: Sachin Wani, Anna Daroszewska, Donald M Salter, Rob J van 't Hof, Stuart H Ralston, Omar M E Albagha

Journal: Dis Model Mech

PubMed ID: 35229101

Doi: 10.1242/dmm.049318

Products & Services: Plasmid DNA Preparation

Recombinant human N-acetylneuraminate lyase as a tool to study clinically relevant mutant variants

Authors: Cheng Cheng, Zi-Xuan Hu, Meng He, Li Liu, Josef Voglmeir

Journal: Carbohydr Res

PubMed ID: 35487178

Doi: 10.1016/j.carres.2022.108561

Products & Services: Mammalian Expression

CLEVER assay: A visual and rapid RNA extraction-free detection of SARS-CoV-2 based on CRISPR-Cas integrated RT-LAMP technology

Authors: Akansha Bhatt, Zeeshan Fatima, Munindra Ruwali, Chitra Seetharam Misra, Shyam Sunder Rangu, Devashish Rath, Ashok Rattan, Saif Hameed

Journal: J Appl Microbiol

PubMed ID: 35396760

Doi: 10.1111/jam.15571

Products & Services: Plasmid DNA Preparation

Insect Cells for High-Yield Production of SARS-CoV-2 Spike Protein: Building a Virosome-Based COVID-19 Vaccine Candidate

Authors: Bárbara Fernandes, Rute Castro, Farien Bhoelan, Denzel Bemelman, Ricardo A Gomes, Júlia Costa, Patrícia Gomes-Alves, Toon Stegmann, Mario Amacker, Paula M Alves, Sylvain Fleury, António Roldão

Journal: Pharmaceutics

PubMed ID: 35456687

Doi: 10.3390/pharmaceutics14040854

Products & Services: Plasmid DNA Preparation

G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2

Authors: Wei Xu, Frank Bearoff, Sandhya Kortagere

Journal: Pharmacol Res

PubMed ID: 35429668

Doi: 10.1016/j.phrs.2022.106223

Products & Services: Proteins, Expression, Isolation and Analysis

A Novel NOX Inhibitor Treatment Attenuates Parkinson's Disease-Related Pathology in Mouse Models

Authors: Anurupa A Ghosh, Dinesh Kumar Verma, Gabriela Cabrera, Kwadwo Ofori, Karina Hernandez-Quijada, Jae-Kwan Kim, Joo Hee Chung, Michael Moore, Sung Hwan Moon, Jong Bok Seo, Yong-Hwan Kim

Journal: Int J Mol Sci

PubMed ID: 35457082

Doi: 10.3390/ijms23084262

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of Single-Molecule Catecholamine Enantiomers Using a Programmable Nanopore

Authors: Wendong Jia, Chengzhen Hu, Yuqin Wang, Yao Liu, Liying Wang, Shanyu Zhang, Qiang Zhu, Yuming Gu, Panke Zhang, Jing Ma, Hong-Yuan Chen, Shuo Huang

Journal: ACS Nano

PubMed ID: 35394745

Doi: 10.1021/acsnano.2c01017

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A Nanopore Based Molnupiravir Sensor

Authors: Wendong Jia , Chengzhen Hu , Yuqin Wang , Panke Zhang , Hong-Yuan Chen , Shuo Huang

Journal: ACS Sens

PubMed ID: 35427117

Doi: 10.1021/acssensors.2c00447

Products & Services: Plasmid DNA Preparation

USP14-regulated allostery of the human proteasome by time-resolved cryo-EM

Authors: Shuwen Zhang , Shitao Zou , Deyao Yin , Lihong Zhao , Daniel Finley , Zhaolong Wu , Youdong Mao

Journal: Nature

PubMed ID: 35477760

Doi: 10.1038/s41586-022-04671-8

Products & Services: Gene Synthesis

Mechanism of sensitivity modulation in the calcium-sensing receptor via electrostatic tuning

Authors: Michael R Schamber , Reza Vafabakhsh

Journal: Nat Commun

PubMed ID: 35459864

Doi: 10.1038/s41467-022-29897-y

Products & Services: ORF cDNA Clones/MolecularCloud

Coenzyme B 12 -dependent and independent photoregulation of carotenogenesis across Myxococcales

Authors: Ricardo Pérez-Castaño , Eva Bastida-Martínez , Jesús Fernández-Zapata , María Del Carmen Polanco , María Luisa Galbis-Martínez , Antonio A Iniesta , Marta Fontes , S Padmanabhan , Montserrat Elías-Arnanz

Journal: Environ Microbiol

PubMed ID: 35005822

Doi: 10.1111/1462-2920.15895

Products & Services: Gene Synthesis

The crystal structure of iC3b-CR3 αI reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor

Authors: Francisco J Fernández, Jorge Santos-López, Rubén Martínez-Barricarte, Javier Querol-García, Héctor Martín-Merinero, Sergio Navas-Yuste, Martin Savko, William E Shepard, Santiago Rodríguez de Córdoba, M Cristina Vega

Journal: Nat Commun

PubMed ID: 35413960

Doi: 10.1038/s41467-022-29580-2

Products & Services: Plasmid DNA Preparation

First computational design using lambda-superstrings and in vivo validation of SARS-CoV-2 vaccine

Authors: Luis Martínez, Iker Malaina, David Salcines-Cuevas, Héctor Terán-Navarro, Andrea Zeoli, Santos Alonso, Ildefonso M De la Fuente, Elena Gonzalez-Lopez, J Gonzalo Ocejo-Vinyals, Mónica Gozalo-Margüello, Jorge Calvo-Montes, Carmen Alvarez-Dominguez

Journal: Sci Rep

PubMed ID: 35440789

Doi: 10.1038/s41598-022-09615-w

Enhanced lipogenesis through Pparγ helps cavefish adapt to food scarcity

Authors: Shaolei Xiong, Wei Wang, Alexander Kenzior, Luke Olsen, Jaya Krishnan, Jenna Persons, Kyle Medley, Robert Peuß, Yongfu Wang, Shiyuan Chen, Ning Zhang, Nancy Thomas, John M Miles, Alejandro Sánchez Alvarado, Nicolas Rohner

Journal: Curr Biol

PubMed ID: 35390280

Doi: 10.1016/j.cub.2022.03.038

Products & Services: GenParts™ DNA Fragments

Mechanistic insights into consumption of the food additive xanthan gum by the human gut microbiota

Authors: Matthew P Ostrowski, Sabina Leanti La Rosa, Benoit J Kunath, Andrew Robertson, Gabriel Pereira, Live H Hagen, Neha J Varghese, Ling Qiu, Tianming Yao, Gabrielle Flint, James Li, Sean P McDonald, Duna Buttner, Nicholas A Pudlo, Matthew K Schnizlein, Vincent B Young, Harry Brumer, Thomas M Schmidt, Nicolas Terrapon, Vincent Lombard, Bernard Henrissat, Bruce Hamaker, Emiley A Eloe-Fadrosh, Ashootosh Tripathi, Phillip B Pope, Eric C Martens

Journal: Nat Microbiol

PubMed ID: 35365790

Doi: 10.1038/s41564-022-01093-0

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Efficacy of convalescent plasma therapy in the patient with COVID-19: a randomised control trial (COPLA-II trial)

Authors: Meenu Bajpai, Ashish Maheshwari, Vikas Dogra, Suresh Kumar, Ekta Gupta, Pratibha Kale, Vandana Saluja, Sherin S Thomas, Nirupama Trehanpati, Chhagan Bihari, Reshu Agarwal, Praveen Bharti, Prabha Shankar, Javid Hussain, Karan Chhabra, Amita Gupta, Ashad Narayanan, Sarika Agarwal, Shruti Jain, Ankit Bhardwaj, Guresh Kumar, Birendra Kumar Yadav, Shiv Kumar Sarin

Journal: BMJ Open

PubMed ID: 35387813

Doi: 10.1136/bmjopen-2021-055189

Products & Services: Recombinant Proteins

Bioactive Hydrolysates from : Optimal Process and Bioactive Properties

Authors: Sara A Cunha, Ezequiel R Coscueta, Paulo Nova, Joana Laranjeira Silva, Maria Manuela Pintado

Journal: Molecules

PubMed ID: 35458702

Doi: 10.3390/molecules27082505

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Blocking TGF- Expression Attenuates Tumor Growth in Lung Cancers, Potentially Mediated by Skewing Development of Neutrophils

Authors: Yifei Fang, Xiyao Li, Yuxuan Jiang, Zhihan Ge

Journal: J Oncol

PubMed ID: 35498537

Doi: 10.1155/2022/3447185

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Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants

Authors: Jessica Hong, Hyung Joon Kwon, Raul Cachau, Catherine Z Chen, Kevin John Butay, Zhijian Duan, Dan Li, Hua Ren, Tianyuzhou Liang, Jianghai Zhu, Venkata P Dandey, Negin P Martin, Dominic Esposito, Uriel Ortega-Rodriguez, Miao Xu, Mario J Borgnia, Hang Xie, Mitchell Ho

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35476528

Doi: 10.1073/pnas.2201433119

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Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions

Authors: Yubai Zhou, Sandip Mukherjee, Daowei Huang, Molee Chakraborty, Chunfang Gu, Guangning Zong, Michael A Stashko, Kenneth H Pearce, Stephen B Shears, Anutosh Chakraborty, Huanchen Wang, Xiaodong Wang

Journal: J Med Chem

PubMed ID: 35467861

Doi: 10.1021/acs.jmedchem.2c00220

Products & Services: Mammalian Expression

Gene Expression in a Humanized 21-Hydroxylase Mouse Model Does Not Affect Adrenocortical Morphology and Function

Authors: Tina Schubert, Nicole Reisch, Ronald Naumann, Ilka Reichardt, Dana Landgraf, Friederike Quitter, Shamini Ramkumar Thirumalasetty, Anne-Kristin Heninger, Mihail Sarov, Mirko Peitzsch, Angela Huebner, Katrin Koehler

Journal: J Endocr Soc

PubMed ID: 35592511

Doi: 10.1210/jendso/bvac062

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Ferritin Light Chain: A Candidate Autoantigen in Immuno-Related Pancytopenia

Authors: Yang Zhang, Shanfeng Hao, Na Xiao, Yu Zhang, Huaquan Wang, Lijuan Li, Rong Fu, Zonghong Shao

Journal: Front Immunol

PubMed ID: 35572557

Doi: 10.3389/fimmu.2022.851096

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TXNDC9 knockdown inhibits lung adenocarcinoma progression by targeting YWHAG

Authors: Jing Wang, Xiaotao Pan, Jie Li, Jin Zhao

Journal: Mol Med Rep

PubMed ID: 35485284

Doi: 10.3892/mmr.2022.12719

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Efficient multinucleotide deletions using deaminase-Cas9 fusions in human cells

Authors: Siyu Chen, Zhiquan Liu, Hao Yu, Liangxue Lai, Zhanjun Li

Journal: J Genet Genomics

PubMed ID: 35421582

Doi: 10.1016/j.jgg.2022.03.007

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Molecular spikes: a gold standard for single-cell RNA counting

Authors: Christoph Ziegenhain, Gert-Jan Hendriks, Michael Hagemann-Jensen, Rickard Sandberg

Journal: Nat Methods

PubMed ID: 35468967

Doi: 10.1038/s41592-022-01446-x

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NADH oxidase of Mycoplasma hyopneumoniae functions as a potential mediator of virulence

Authors: Fei Hao, Xing Xie, Zhixin Feng, Rong Chen, Yanna Wei, Jin Liu, Qiyan Xiong, Guoqing Shao, Johnson Lin

Journal: BMC Vet Res

PubMed ID: 35366872

Doi: 10.1186/s12917-022-03230-7

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Transcriptome analysis reveals the regulatory mechanism by which suppresses adventitious shoot formation in apple

Authors: Jiangping Mao, Doudou Ma, Chundong Niu, Xiaolong Ma, Ke Li, Muhammad Mobeen Tahir, Shiyue Chen, Xiuxiu Liu, Dong Zhang

Journal: Hortic Res

PubMed ID: 35669707

Doi: 10.1093/hr/uhac080

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Histone acetyltransferase GCN5-mediated lysine acetylation modulates salt stress aadaption of Trichoderma

Authors: Zhe Li, Hao Zhang, Chunjing Cai, Zhong Lin, Zhen Zhen, Jie Chu, Kai Guo

Journal: Appl Microbiol Biotechnol

PubMed ID: 35376971

Doi: 10.1007/s00253-022-11897-z

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Glycoside hydrolase from the GH76 family indicates that marine Salegentibacter sp Hel_I_6 consumes alpha-mannan from fungi

Authors: Vipul Solanki, Karen Krüger, Conor J Crawford, Alonso Pardo-Vargas, José Danglad-Flores, Kim Le Mai Hoang, Leeann Klassen, D Wade Abbott, Peter H Seeberger, Rudolf I Amann, Hanno Teeling, Jan-Hendrik Hehemann

Journal: ISME J

PubMed ID: 35414716

Doi: 10.1038/s41396-022-01223-w

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Deletion and tandem duplications of biosynthetic genes drive the diversity of triterpenoids in Aralia elata

Authors: Yu Wang, He Zhang, Hyok Chol Ri, Zeyu An, Xin Wang, Jia-Nan Zhou, Dongran Zheng, Hao Wu, Pengchao Wang, Jianfei Yang, Ding-Kun Liu, Diyang Zhang, Wen-Chieh Tsai, Zheyong Xue, Zhichao Xu, Peng Zhang, Zhong-Jian Liu, Hailong Shen, Yuhua Li

Journal: Nat Commun

PubMed ID: 35468919

Doi: 10.1038/s41467-022-29908-y

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Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit

Authors: Nicholas K Hurlburt, Leah J Homad, Irika Sinha, Madeleine F Jennewein, Anna J MacCamy, Yu-Hsin Wan, Jim Boonyaratanakornkit, Anton M Sholukh, Abigail M Jackson, Panpan Zhou, Dennis R Burton, Raiees Andrabi, Gabriel Ozorowski, Andrew B Ward, Leonidas Stamatatos, Marie Pancera, Andrew T McGuire

Journal: Commun Biol

PubMed ID: 35411021

Doi: 10.1038/s42003-022-03262-7

Products & Services: Recombinant Proteins

Dynamic of anti-spike receptor binding domain (RBD) levels and short-term adverse events following a heterologous booster dose of BNT162b2 after two doses of CoronaVac in Thai health care workers

Authors: Amonrphat Kitro, Wachiranun Sirikul, Weeraya Thongkum, Suthinee Soponpong, Umpa Yasamut, Wuttipat Kiratipaisarl, Apiradee Kosai, Watchara Kasinrerk, Chatchai Tayapiwatana, Kriengkrai Srithanaviboonchai

Journal: Vaccine

PubMed ID: 35430106

Doi: 10.1016/j.vaccine.2022.04.020

Correction to "Febuxostat Prevents the Cytotoxicity of Propofol in Brain Endothelial Cells"

Authors: Jianli Hao, Weiqing Zhang, Rui Tong, Zeqing Huang

Journal: ACS Omega

PubMed ID: 35465124

Doi: 10.1021/acsomega.2c01716

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Topology of the Enterobacterial Common Antigen polymerase WzyE

Authors: Nicholas T Maczuga, Elizabeth N H Tran, Renato Morona

Journal: Microbiology (Reading)

PubMed ID: 35470793

Doi: 10.1099/mic.0.001183

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Recombinant Limosilactobacillus (Lactobacillus) delivering nanobodies against Clostridium perfringens NetB and alpha toxin confers potential protection from necrotic enteritis

Authors: Dharanesh Gangaiah, Valerie Ryan, Daphne Van Hoesel, Shrinivasrao P Mane, Enid T Mckinley, Nallakannu Lakshmanan, Nandakumar D Reddy, Edward Dolk, Arvind Kumar

Journal: Microbiologyopen

PubMed ID: 35478283

Doi: 10.1002/mbo3.1270

Products & Services: Proteins, Expression, Isolation and Analysis

NEAT1: Culprit lncRNA linking PIG-C, MSLN, and CD80 in triple-negative breast cancer

Authors: Nada H Hussein, Reda A Eissa, M de Bruyn, Hend M El Tayebi

Journal: Life Sci

PubMed ID: 35378140

Doi: 10.1016/j.lfs.2022.120523

Products & Services: Proteins, Expression, Isolation and Analysis

Dataset of high-throughput ligand screening against the RNA Packaging Signals regulating Hepatitis B Virus nucleocapsid formation

Authors: Fardokht Abulwerdi, Farzad Fatehi, Iain W Manfield, Stuart F J Le Grice, John S Schneekloth, Reidun Twarock, Peter G Stockley, Nikesh Patel

Journal: Data Brief

PubMed ID: 35516001

Doi: 10.1016/j.dib.2022.108206

Products & Services: Proteins, Expression, Isolation and Analysis

CCPG1 involved in corneal infection

Authors: Li-Mei Wang, Xiao-Meng Chen, Hai-Jing Yan, Shu Yan, Xiao-Yan Sun, Da-Wei Zhang, Hua Yang, Dan-Li Lu, Cheng-Ye Che

Journal: Int J Ophthalmol

PubMed ID: 35450172

Doi: 10.18240/ijo.2022.04.03

Products & Services: Proteins, Expression, Isolation and Analysis

Cloning and Organelle Expression of Bamboo Mitochondrial Complex I Subunits Nad1, Nad2, Nad4, and Nad5 in the Yeast

Authors: Hsieh-Chin Tsai, Cheng-Hung Hsieh, Ching-Wen Hsu, Yau-Heiu Hsu, Lee-Feng Chien

Journal: Int J Mol Sci

PubMed ID: 35409414

Doi: 10.3390/ijms23074054

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Ethyl Gallate Dual-Targeting PTPN6 and PPARγ Shows Anti-Diabetic and Anti-Obese Effects

Authors: Dohee Ahn, Jinsoo Kim, Gibeom Nam, Xiaodi Zhao, Jihee Kwon, Ji Young Hwang, Jae Kwan Kim, Sun-Young Yoon, Sang J Chung

Journal: Int J Mol Sci

PubMed ID: 35563411

Doi: 10.3390/ijms23095020

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LPS Response Is Impaired by Urban Fine Particulate Matter

Authors: Natália de Souza Xavier Costa, Gabriel Ribeiro Júnior, Adair Aparecida Dos Santos Alemany, Luciano Belotti, Marcela Frota Cavalcante, Susan Ribeiro, Mariana Matera Veras, Esper Georges Kallás, Paulo Hilário Nascimento Saldiva, Marisa Dolhnikoff, Luiz Fernando Ferraz da Silva

Journal: Int J Mol Sci

PubMed ID: 35409273

Doi: 10.3390/ijms23073913

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Identification and characterization of novel endolysins targeting Gardnerella vaginalis biofilms to treat bacterial vaginosis

Authors: Sara Arroyo-Moreno, Matthew Cummings, David B Corcoran, Aidan Coffey, Ronan R McCarthy

Journal: NPJ Biofilms Microbiomes

PubMed ID: 35440653

Doi: 10.1038/s41522-022-00285-0

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MicroRNA-217 modulates pancreatic cancer progression via targeting ATAD2

Authors: Madhuri Dutta, Biswajit Das, Debasish Mohapatra, Padmanava Behera, Shantibhusan Senapati, Anasuya Roychowdhury

Journal: Life Sci

PubMed ID: 35504332

Doi: 10.1016/j.lfs.2022.120592

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Peptide Permeation across a Phosphocholine Membrane: An Atomically Detailed Mechanism Determined through Simulations and Supported by Experimentation

Authors: Alfredo E Cardenas, Chad I Drexler, Rachel Nechushtai, Ron Mittler, Assaf Friedler, Lauren J Webb, Ron Elber

Journal: J Phys Chem B

PubMed ID: 35388695

Doi: 10.1021/acs.jpcb.1c10966

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A GH115 α-glucuronidase structure reveals dimerization-mediated substrate binding and a proton wire potentially important for catalysis

Authors: Casper Wilkens, Marlene Vuillemin, Bo Pilgaard, Igor Polikarpov, Jens Preben Morth

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35503213

Doi: 10.1107/S2059798322003527

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Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs

Authors: Helena Tossavainen, Hasan Uğurlu, Mikael Karjalainen, Maarit Hellman, Lina Antenucci, Riku Fagerlund, Kalle Saksela, Perttu Permi

Journal: Structure

PubMed ID: 35390274

Doi: 10.1016/j.str.2022.03.006

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Impact of Moderna mRNA-1273 Booster Vaccine on Fully Vaccinated High-Risk Chronic Dialysis Patients after Loss of Humoral Response

Authors: Sammy Patyna, Timon Eckes, Benjamin F Koch, Stephan Sudowe, Anke Oftring, Niko Kohmer, Holger F Rabenau, Sandra Ciesek, Despina Avaniadi, Rahel Steiner, Ingeborg A Hauser, Josef M Pfeilschifter, Christoph Betz

Journal: Vaccines (Basel)

PubMed ID: 35455334

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BRAF Modulates Lipid Use and Accumulation

Authors: Jacqueline A Turner, Emily L Paton, Robert Van Gulick, Davide Stefanoni, Francesca Cendali, Julie Reisz, Richard P Tobin, Martin McCarter, Angelo D'Alessandro, Raul M Torres, William A Robinson, Kasey L Couts, Isabel R Schlaepfer

Journal: Cancers (Basel)

PubMed ID: 35565240

Doi: 10.3390/cancers14092110

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production of pederin by labrenzin pathway expansion

Authors: Dina Kačar, Carmen Schleissner, Librada M Cañedo, Pilar Rodríguez, Fernando de la Calle, Carmen Cuevas, Beatriz Galán, José Luis García

Journal: Metab Eng Commun

PubMed ID: 35517715

Doi: 10.1016/j.mec.2022.e00198

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NADPH-Cytochrome P450 Reductase Mediates the Fatty Acid Desaturation of ω3 and ω6 Desaturases from

Authors: Mingxuan Wang, Jing Li, Wenjie Cong, Jianguo Zhang

Journal: Curr Issues Mol Biol

PubMed ID: 35678654

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Simultaneous Measurement of IgM and IgG Antibodies to SARS-CoV-2 Spike, RBD, and Nucleocapsid Multiplexed in a Single Assay on the xMAP INTELLIFLEX DR-SE Flow Analyzer

Authors: Andrew Cameron, Jessica L Bohrhunter, Claire A Porterfield, Rupinder Mangat, Michael H Karasick, Zachary Pearson, Stephen Angeloni, Nicole D Pecora

Journal: Microbiol Spectr

PubMed ID: 35389244

Doi: 10.1128/spectrum.02507-21

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Safety and Immunogenicity of a Booster Vaccination by CoronaVac or BNT162b2 in Previously Two-Dose Inactivated Virus Vaccinated Individuals with Negative Neutralizing Antibody

Authors: Kristi Tsz-Wan Lai, Emilie Yuen-Ting Lai Wan Loong, Terry Ling-Hiu Fung, Luke Wing-Pan Luk, Chor-Chiu Lau, Jonpaul Sze-Tsing Zee, Edmond Shiu-Kwan Ma, Bone Siu-Fai Tang

Journal: Vaccines (Basel)

PubMed ID: 35455305

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Immunoreactivity of humanized single-chain variable fragment against its functional epitope on domain 1 of CD147

Authors: Nutjeera Intasai, Kuntalee Rangnoi, Montarop Yamabhai, Thanathat Pamonsupornwichit, Weeraya Thongkum, Umpa Yasamut, Koollawat Chupradit, Nuchjira Takheaw, Piyarat Nimmanpipug, Chatchai Tayapiwatana

Journal: Sci Rep

PubMed ID: 35468972

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A genetic toolkit and gene switches to limit Mycoplasma growth for biosafety applications

Authors: Alicia Broto, Erika Gaspari, Samuel Miravet-Verde, Vitor A P Martins Dos Santos, Mark Isalan

Journal: Nat Commun

PubMed ID: 35393441

Doi: 10.1038/s41467-022-29574-0

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pH-Responsive Polymer Nanoparticles for Efficient Delivery of Cas9 Ribonucleoprotein With or Without Donor DNA

Authors: Ruosen Xie, Xiuxiu Wang, Yuyuan Wang, Mingzhou Ye, Yi Zhao, Brian S Yandell, Shaoqin Gong

Journal: Adv Mater

PubMed ID: 35119139

Doi: 10.1002/adma.202110618

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Antimicrobial and Immunomodulatory Effects of Selected Chemokine and Antimicrobial Peptide on Cytokine Profile during Typhimurium Infection in Mouse

Authors: Astrid Tuxpan-Pérez, Marco Antonio Ibarra-Valencia, Blanca Elisa Estrada, Herlinda Clement, Ligia Luz Corrales-García, Gerardo Pavel Espino-Solis, Gerardo Corzo

Journal: Antibiotics (Basel)

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Bma-LAD-2, an Intestinal Cell Adhesion Protein, as a Potential Therapeutic Target for Lymphatic Filariasis

Authors: Alexander F Flynn, Rebekah T Taylor, Marzena E Pazgier, Sasisekhar Bennuru, Alyssa R Lindrose, Spencer L Sterling, C Paul Morris, Brynna I Gleeson, Tim K Maugel, Thomas B Nutman, Edward Mitre

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PubMed ID: 35475643

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Multifunctional polyphenol-based silk hydrogel alleviate soxidative stress and enhances endogenous regeneration of osteochondral defects.

Authors: Wei Zhang 1 2 3, Yanan Zhang 1, Xiaolong Li 1, Zhicheng Cao 1 4, Qingyun Mo 1, Renwang Sheng 1, Chen Ling 1 4, Jiayu Chi 1, Qingqiang Yao 4 3, Jialin Chen 1 2 3, Hongmei Wang 1

Journal: Mater Today Bio

PubMed ID: 35469254

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A polyesterase from the Antarctic bacterium Moraxella sp degrades highly crystalline synthetic polymers

Authors: Efstratios Nikolaivits, George Taxeidis, Christina Gkountela, Stamatina Vouyiouka, Veselin Maslak, Jasmina Nikodinovic-Runic, Evangelos Topakas

Journal: J Hazard Mater

PubMed ID: 35452981

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Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry

Authors: Tanaya Bagga, Nikhil Kumar Tulsian, Yu Keung Mok, R Manjunatha Kini, J Sivaraman

Journal: Cell Mol Life Sci

PubMed ID: 35397701

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Impaired Humoral Immunity with Concomitant Preserved T Cell Reactivity in IBD Patients on Treatment with Infliximab 6 Month after Vaccination with the SARS-CoV-2 mRNA Vaccine BNT162b2: A Pilot Study

Authors: Richard Vollenberg, Phil-Robin Tepasse, Eva Lorentzen, Tobias Max Nowacki

Journal: J Pers Med

PubMed ID: 35629116

Doi: 10.3390/jpm12050694

SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 T cells

Authors: Anastasia A Minervina, Mikhail V Pogorelyy, Allison M Kirk, Jeremy Chase Crawford, E Kaitlynn Allen, Ching-Heng Chou, Robert C Mettelman, Kim J Allison, Chun-Yang Lin, David C Brice, Xun Zhu, Kasi Vegesana, Gang Wu, Sanchit Trivedi, Pratibha Kottapalli, Daniel Darnell, Suzanne McNeely, Scott R Olsen, Stacey Schultz-Cherry, Jeremie H Estepp, Maureen A McGargill, Joshua Wolf, Paul G Thomas

Journal: Nat Immunol

PubMed ID: 35383307

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A Single-Domain TCR-like Antibody Selective for the Qa-1/Qdm Peptide Complex Enhances Tumoricidal Activity of NK Cells via Blocking the NKG2A Immune Checkpoint

Authors: Soroush Ghaffari, Katherine Upchurch-Ange, Susanne Gimlin, Trivendra Tripathi, Marjolein Sluijter, Jim Middelburg, Thorbald van Hall, Jon Weidanz

Journal: J Immunol

PubMed ID: 35418467

Doi: 10.4049/jimmunol.2100790

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Structural insight into UV-B-activated UVR8 bound to COP1

Authors: Yidong Wang, Lixia Wang, Zeyuan Guan, Hongfei Chang, Ling Ma, Cuicui Shen, Liang Qiu, Junjie Yan, Delin Zhang, Jian Li, Xing Wang Deng, Ping Yin

Journal: Sci Adv

PubMed ID: 35442727

Doi: 10.1126/sciadv.abn3337

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Humoral immunity against SARS-CoV-2 variants including omicron in solid organ transplant recipients after three doses of a COVID-19 mRNA vaccine

Authors: Kapil K Saharia, Jennifer S Husson, Silke V Niederhaus, Thierry Iraguha, Stephanie V Avila, Youngchae J Yoo, Nancy M Hardy, Xiaoxuan Fan, Destiny Omili, Alice Crane, Amber Carrier, Wen Y Xie, Erica Vander Mause, Kim Hankey, Sherri Bauman, Patricia Lesho, Heather D Mannuel, Ashish Ahuja, Minu Mathew, James Avruch, John Baddley, Olga Goloubeva, Kirti Shetty, Saurabh Dahiya, Aaron P Rapoport, Tim Luetkens, Djordje Atanackovic

Journal: Clin Transl Immunology

PubMed ID: 35505864

Doi: 10.1002/cti2.1391

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Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured Cu supplants entropically favoured Zn to form Cu clusters under physiological conditions

Authors: Matthew R Mehlenbacher, Rahma Elsiesy, Rabina Lakha, Rhiza Lyne E Villones, Marina Orman, Christina L Vizcarra, Gabriele Meloni, Dean E Wilcox, Rachel N Austin

Journal: Chem Sci

PubMed ID: 35655557

Doi: 10.1039/d2sc00676f

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Tripartite motif containing 63, regulated by E26 transformation specific variant 4, facilitates the thyroid carcinoma progression and the AKT, p38, and ERK signaling pathways

Authors: Jingni He, Ying Zhang, Baiyu Yao, Lidong Wang, Zhong Tian

Journal: Mol Cell Endocrinol

PubMed ID: 35390449

Doi: 10.1016/j.mce.2022.111639

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Melatonin Mediated Differential Regulation of Drought Tolerance in Sensitive and Tolerant Varieties of Upland Cotton (

Authors: Laha Supriya, Pullaiahgari Durgeshwar, Mehanathan Muthamilarasan, Gudipalli Padmaja

Journal: Front Plant Sci

PubMed ID: 35444676

Doi: 10.3389/fpls.2022.821353

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Nutrient sensitive protein -GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis

Authors: Shama Parween, Thilina T Alawathugoda, Ashok D Prabakaran, S Thameem Dheen, Randall H Morse, Bright Starling Emerald, Suraiya A Ansari

Journal: Life Sci Alliance

PubMed ID: 35470239

Doi: 10.26508/lsa.202201385

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Peptide of Infective Larval Extract That Harnesses Growth of Human Hepatoma Cells

Authors: Pichet Ruenchit, Onrapak Reamtong, Ladawan Khowawisetsut, Poom Adisakwattana, Monrat Chulanetra, Kasem Kulkeaw, Wanpen Chaicumpa

Journal: Front Cell Infect Microbiol

PubMed ID: 35558100

Doi: 10.3389/fcimb.2022.882608

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Restoration of Sarco/Endoplasmic Reticulum Ca-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca Depletion

Authors: Wen Zhang, Fanghua Ye, Nan Pang, Miriam Kessi, Juan Xiong, Shimeng Chen, Jing Peng, Li Yang, Fei Yin

Journal: Front Pharmacol

PubMed ID: 35517826

Doi: 10.3389/fphar.2022.877175

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BDSF Is a Degradation-Prone Quorum-Sensing Signal Detected by the Histidine Kinase RpfC of pv

Authors: Xiu-Qi Tian, Yao Wu, Zhen Cai, Wei Qian

Journal: Appl Environ Microbiol

PubMed ID: 35369702

Doi: 10.1128/aem.00031-22

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Multiple-Allele MHC Class II Epitope Engineering by a Molecular Dynamics-Based Evolution Protocol

Authors: Rodrigo Ochoa, Victoria Alves Santos Lunardelli, Daniela Santoro Rosa, Alessandro Laio, Pilar Cossio

Journal: Front Immunol

PubMed ID: 35572587

Doi: 10.3389/fimmu.2022.862851

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A conserved module regulates receptor kinase signalling in immunity and development

Authors: Thomas A DeFalco, Pauline Anne, Sean R James, Andrew C Willoughby, Florian Schwanke, Oliver Johanndrees, Yasmine Genolet, Paul Derbyshire, Qian Wang, Surbhi Rana, Anne-Marie Pullen, Frank L H Menke, Cyril Zipfel, Christian S Hardtke, Zachary L Nimchuk

Journal: Nat Plants

PubMed ID: 35422079

Doi: 10.1038/s41477-022-01134-w

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Gain-of-function and loss-of-function GABRB3 variants lead to distinct clinical phenotypes in patients with developmental and epileptic encephalopathies

Authors: Nathan L Absalom, Vivian W Y Liao, Katrine M H Johannesen, Elena Gardella, Julia Jacobs, Gaetan Lesca, Zeynep Gokce-Samar, Alexis Arzimanoglou, Shimriet Zeidler, Pasquale Striano, Pierre Meyer, Ira Benkel-Herrenbrueck, Inger-Lise Mero, Jutta Rummel, Mary Chebib, Rikke S Møller, Philip K Ahring

Journal: Nat Commun

PubMed ID: 35383156

Doi: 10.1038/s41467-022-29280-x

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The Readthrough Isoform AQP4ex Is Constitutively Phosphorylated in the Perivascular Astrocyte Endfeet of Human Brain

Authors: Roberta Pati, Claudia Palazzo, Onofrio Valente, Pasqua Abbrescia, Raffaella Messina, Nicoletta Concetta Surdo, Konstantinos Lefkimmiatis, Francesco Signorelli, Grazia Paola Nicchia, Antonio Frigeri

Journal: Biomolecules

PubMed ID: 35625560

Doi: 10.3390/biom12050633

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