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Impedimetric and amperometric genosensors for the highly sensitive quantification of SARS-CoV-2 nucleic acid using an avidin-functionalized multi-walled carbon nanotubes biocapture platform

Authors: Michael López Mujica, Alejandro Tamborelli, Andrés Castellaro, Danilo Barcudi, María D Rubianes, Marcela C Rodríguez, Héctor A Saka, José L Bocco, Pablo R Dalmasso, Gustavo A Rivas

Journal: Biosens Bioelectron X

PubMed ID: 36118917

Doi: 10.1016/j.biosx.2022.100222

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The structure of a polyketide synthase bimodule core

Authors: Yves U Tittes, Dominik A Herbst, Solène F X Martin, Hugo Munoz-Hernandez, Roman P Jakob, Timm Maier

Journal: Sci Adv

PubMed ID: 36129979

Doi: 10.1126/sciadv.abo6918

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Multiplex real-time PCR for the detection and differentiation of equid gammaherpesvirus 2 and 5

Authors: Flavia Fürer, Cornel Fraefel, Julia Lechmann

Journal: J Virol Methods

PubMed ID: 36087793

Doi: 10.1016/j.jviromet.2022.114615

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Characterisation of a common hotspot variant in acute intermittent porphyria sheds light on the mechanism of hydroxymethylbilane synthase function

Authors: Marthe S Christie, Mikko Laitaoja, Aasne K Aarsand, Juha P Kallio, Helene J Bustad

Journal: FEBS Open Bio

PubMed ID: 36115019

Doi: 10.1002/2211-5463.13490

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Sulfanegen stimulates 3-mercaptopyruvate sulfurtransferase activity and ameliorates Alzheimer's disease pathology and oxidative stress in vivo

Authors: Swetha Pavani Rao, Wei Xie, Ye In Christopher Kwon, Nicholas Juckel, Jiashu Xie, Venkateshwara Rao Dronamraju, Robert Vince, Michael K Lee, Swati S More

Journal: Redox Biol

PubMed ID: 36183541

Doi: 10.1016/j.redox.2022.102484

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A circular RNA derived from GLIS3 accelerates the proliferation of glioblastoma cells through competitively binding with miR-449c-5p to upregulate CAPG and GLIS3

Authors: Qingjiu Zhou, Mahati Shaya, Yalikun Kugeluke, Qiang Fu, Shaoshan Li, Yisireyili Dilimulati

Journal: BMC Neurosci

PubMed ID: 36114444

Doi: 10.1186/s12868-022-00736-6

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Sec18 supports membrane fusion by promoting Sec17 membrane association

Authors: Amy Orr, William Wickner

Journal: Mol Biol Cell

PubMed ID: 36103252

Doi: 10.1091/mbc.E22-07-0274

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Rapid Evaluation of Vaccine Booster Effectiveness against SARS-CoV-2 Variants

Authors: Hoi Lok Cheng, Sing Mei Lim, Huan Jia, Ming Wei Chen, Say Yong Ng, Xiaohong Gao, Jyoti Somani, Sharmila Sengupta, Dousabel M Y Tay, Patrina W L Chua, Abirami R, Sharon Y H Ling, Megan E McBee, Barnaby E Young, Hadley D Sikes, Peter R Preiser

Journal: Microbiol Spectr

PubMed ID: 36069616

Doi: 10.1128/spectrum.02257-22

Functional characterization of putative ecdysone transporters in lepidopteran pests

Authors: George-Rafael Samantsidis, Melina Fotiadou, Savvas Tzavellas, Sven Geibel, Ralf Nauen, Luc Swevers, Shane Denecke, John Vontas

Journal: Insect Biochem Mol Biol

PubMed ID: 36064128

Doi: 10.1016/j.ibmb.2022.103830

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PGAM1 Promotes Glycolytic Metabolism and Paclitaxel Resistance via Pyruvic Acid Production in Ovarian Cancer Cells

Authors: Yan Feng, Xu Zhang, Songfa Zhang, Shanshan Xu, Xiaojing Chen, Caiyun Zhou, Yongmei Xi, Xing Xie, Weiguo Lu

Journal: Front Biosci (Landmark Ed)

PubMed ID: 36224008

Doi: 10.31083/j.fbl2709262

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Atomic force microscopy measurements and model of DNA bending caused by binding of AraC protein

Authors: Mary Lowe, Benjamin Glezer, Brendan Toulan, Brian Hess

Journal: J Mol Recognit

PubMed ID: 36112092

Doi: 10.1002/jmr.2993

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Tag-Dependent Substrate Selection of ClpX Underlies Secondary Differentiation of Chlamydia trachomatis

Authors: Nicholas A Wood, Abigail R Swoboda, Amanda M Blocker, Derek J Fisher, Scot P Ouellette

Journal: MBio

PubMed ID: 36154190

Doi: 10.1128/mbio.01858-22

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Ectopic expression of meiotic cohesin generates chromosome instability in cancer cell line

Authors: Abdelhalim Boukaba, Jian Liu, Carl Ward, Qiongfang Wu, Alexei Arnaoutov, Jierong Liang, Elena M Pugacheva, Mary Dasso, Victor Lobanenkov, Miguel Esteban, Alexander V Strunnikov

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36179046

Doi: 10.1073/pnas.2204071119

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The KdmB-EcoA-RpdA-SntB chromatin complex binds regulatory genes and coordinates fungal development with mycotoxin synthesis

Authors: Betim Karahoda, Lakhansing Pardeshi, Mevlut Ulas, Zhiqiang Dong, Niranjan Shirgaonkar, Shuhui Guo, Fang Wang, Kaeling Tan, Özlem Sarikaya-Bayram, Ingo Bauer, Paul Dowling, Alastair B Fleming, Brandon T Pfannenstiel, Dianiris Luciano-Rosario, Harald Berger, Stefan Graessle, Mohamed M Alhussain, Joseph Strauss, Nancy P Keller, Koon Ho Wong, Özgür Bayram

Journal: Nucleic Acids Res

PubMed ID: 36095118

Doi: 10.1093/nar/gkac744

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A Comparison of Dinoflagellate Thiolation Domain Binding Proteins Using In Vitro and Molecular Methods

Authors: Ernest Williams, Tsvetan Bachvaroff, Allen Place

Journal: Mar Drugs

PubMed ID: 36135770

Doi: 10.3390/md20090581

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Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models

Authors: Masoume Alipour, Majid Tebianian, Nahid Tofigh, Reyhaneh Sadat Taheri, Sayed Alireza Mousavi, Asal Naseri, Amin Ahmadi, Nayla Munawar, Koorosh Shahpasand

Journal: Neuropeptides

PubMed ID: 36087426

Doi: 10.1016/j.npep.2022.102285

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The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues

Authors: Sinan Gai, Kajitha Suthagar, Karl J Shaffer, Wanting Jiao, Yacoba V T Minnow, Kayla Glockzin, Sean W Maatouk, Ardala Katzfuss, Thomas D Meek, Vern L Schramm, Peter C Tyler

Journal: Bioorg Med Chem

PubMed ID: 36209571

Doi: 10.1016/j.bmc.2022.117038

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Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses

Authors: Kah Lok Chan, Juliana Gomez, Chelisa Cardinez, Nishi Kumari, Christina E Sparbier, Enid Y N Lam, Miriam M Yeung, Sylvain Garciaz, James A Kuzich, Doen Ming Ong, Fiona C Brown, Yih-Chih Chan, Dane Vassiliadis, Elanor N Wainwright, Ali Motazedian, Andrea Gillespie, Katie A Fennell, Junyun Lai, Imran G House, Laura Macpherson, Ching-Seng Ang, Sarah-Jane Dawson, Paul A Beavis, Andrew H Wei, Marian L Burr, Mark A Dawson

Journal: Cancer Cell

PubMed ID: 36179686

Doi: 10.1016/j.ccell.2022.09.007

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Involvement of transmembrane protein 184a during angiogenesis in zebrafish embryos

Authors: Cassandra J Field, Alexis M Perez, Taryn Samet, Victoria Ricles, M Kathryn Iovine, Linda J Lowe-Krentz

Journal: Front Physiol

PubMed ID: 36117693

Doi: 10.3389/fphys.2022.845407

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White spot syndrome virus directly activates mTORC1 signaling to facilitate its replication via polymeric immunoglobulin receptor-mediated infection in shrimp

Authors: Pan-Pan Hong, Cang Li, Guo-Juan Niu, Xiao-Fan Zhao, Jin-Xing Wang

Journal: PLoS Pathog

PubMed ID: 36067252

Doi: 10.1371/journal.ppat.1010808

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High-efficiency recombinant protein purification using mCherry and YFP nanobody affinity matrices

Authors: Anh T Q Cong, Taylor L Witter, Matthew J Schellenberg

Journal: Protein Sci

PubMed ID: 36040252

Doi: 10.1002/pro.4383

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Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis

Authors: Yong Chen, Zhuyin Wu, Shijia Huang, Xiaoxia Wang, Sijia He, Lin Liu, Yurong Hu, Li Chen, Peng Chen, Songzi Liu, Shengqi He, Bo Shan, Ling Zheng, Sheng-Zhong Duan, Zhiyin Song, Lei Jiang, Qiong A Wang, Zhenji Gan, Bao-Liang Song, Jianmiao Liu, Liangyou Rui, Mengle Shao, Yong Liu

Journal: Nat Metab

PubMed ID: 36123394

Doi: 10.1038/s42255-022-00631-8

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Molecular advances to study the function, evolution and spectral tuning of arthropod visual opsins

Authors: Marjorie A Liénard, Wendy A Valencia-Montoya, Naomi E Pierce

Journal: Philos Trans R Soc Lond B Biol Sci

PubMed ID: 36058235

Doi: 10.1098/rstb.2021.0279

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Generation and characterization of mouse monoclonal antibodies against the VP4 protein of group A human rotaviruses

Authors: Yuanjun Zeng, Feibo Song, Guoxing Luo, Han Yang, Cao Li, Wei Liu, Tingdong Li, Shiyin Zhang, Yingbin Wang, Chenghao Huang, Shengxiang Ge, Jun Zhang, Ningshao Xia

Journal: Antiviral Res

PubMed ID: 36152816

Doi: 10.1016/j.antiviral.2022.105407

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Developmental dynamics of RNA translation in the human brain

Authors: Erin E Duffy, Benjamin Finander, GiHun Choi, Ava C Carter, Iva Pritisanac, Aqsa Alam, Victor Luria, Amir Karger, William Phu, Maxwell A Sherman, Elena G Assad, Naomi Pajarillo, Alexandra Khitun, Elizabeth E Crouch, Sanika Ganesh, Jin Chen, Bonnie Berger, Nenad Sestan, Anne O'Donnell-Luria, Eric J Huang, Eric C Griffith, Julie D Forman-Kay, Alan M Moses, Brian T Kalish, Michael E Greenberg

Journal: Nat Neurosci

PubMed ID: 36171426

Doi: 10.1038/s41593-022-01164-9

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Residues L55 and W69 of Tva Mediate Entry of Subgroup A Avian Leukosis Virus

Authors: Yuntong Chen, Suyan Wang, Xinyi Li, Mengmeng Yu, Peng Liu, Lingzhai Meng, Ru Guo, Xiaoyan Feng, Aijing Liu, Xiaole Qi, Kai Li, Li Gao, Qing Pan, Yanping Zhang, Changjun Liu, Hongyu Cui, Xiaomei Wang, Yulong Gao

Journal: J Virol

PubMed ID: 36069550

Doi: 10.1128/jvi.00678-22

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Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis

Authors: Marcela A Ferrada, Sinisa Savic, Daniela Ospina Cardona, Jason C Collins, Hugh Alessi, Fernanda Gutierrez-Rodrigues, Dinesh Babu Uthaya Kumar, Lorena Wilson, Wendy Goodspeed, James S Topilow, Julie J Paik, James A Poulter, Tanaz A Kermani, Matthew J Koster, Kenneth J Warrington, Catherine Cargo, Rachel S Tattersall, Christopher J A Duncan, Anna Cantor, Patrycja Hoffmann, Elspeth M Payne, Hanna Bonnekoh, Karoline Krause, Edward W Cowen, Katherine R Calvo, Bhavisha A Patel, Amanda K Ombrello, Daniel L Kastner, Neal S Young, Achim Werner, Peter C Grayson, David B Beck

Journal: Blood

PubMed ID: 35793467

Doi: 10.1182/blood.2022016985

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Structure of the PAPP-A complex reveals mechanism of substrate recognition

Authors: Russell A Judge, Janani Sridar, Kathryn Tunyasuvunakool, Rinku Jain, John C K Wang, Christna Ouch, Jun Xu, Amirhossein Mafi, Aaron H Nile, Clint Remarcik, Corey L Smith, Crystal Ghosh, Chen Xu, Vincent Stoll, John Jumper, Amoolya H Singh, Dan Eaton, Qi Hao

Journal: Nat Commun

PubMed ID: 36127359

Doi: 10.1038/s41467-022-33175-2

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C3- and C3/C5-Epimerases Required for the Biosynthesis of the Capsular Polysaccharides from

Authors: Manas K Ghosh, Dao Feng Xiang, James B Thoden, Hazel M Holden, Frank M Raushel

Journal: Biochemistry

PubMed ID: 36093987

Doi: 10.1021/acs.biochem.2c00364

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terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells

Authors: Joshua A Nord, Sarah L Wynia-Smith, Alyssa L Gehant, Rachel A Jones Lipinski, Aaron Naatz, Inmaculada Rioja, Rab K Prinjha, John A Corbett, Brian C Smith

Journal: Front Endocrinol (Lausanne)

PubMed ID: 36176467

Doi: 10.3389/fendo.2022.923925

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Utilization of Receptor-Binding Domain of SARS-CoV-2 Spike Protein Expressed in Escherichia coli for the Development of Neutralizing Antibody Assay

Authors: Termsak Tantiwiwat, Apisitt Thaiprayoon, Ake-Kavitch Siriatcharanon, Chakrit Tachaapaikoon, Nongluk Plongthongkum, Dujduan Waraho-Zhmayev

Journal: Mol Biotechnol

PubMed ID: 36103078

Doi: 10.1007/s12033-022-00563-4

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Complementary crosstalk between palmitoylation and phosphorylation events in MTIP regulates its role during invasion

Authors: Zille Anam, Geeta Kumari, Soumyadeep Mukherjee, Devasahayam Arokia Balaya Rex, Shreeja Biswas, Preeti Maurya, Susendaran Ravikumar, Nutan Gupta, Akhilesh Kumar Kushawaha, Raj Kumar Sah, Ayushi Chaurasiya, Jhalak Singhal, Niharika Singh, Shikha Kaushik, T S Keshava Prasad, Soumya Pati, Anand Ranganathan, Shailja Singh

Journal: Front Cell Infect Microbiol

PubMed ID: 36250062

Doi: 10.3389/fcimb.2022.924424

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Structural basis for directional chitin biosynthesis

Authors: Wei Chen, Peng Cao, Yuansheng Liu, Ailing Yu, Dong Wang, Lei Chen, Rajamanikandan Sundarraj, Zhiguang Yuchi, Yong Gong, Hans Merzendorfer, Qing Yang

Journal: Nature

PubMed ID: 36131020

Doi: 10.1038/s41586-022-05244-5

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Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase

Authors: Chenyan Chang, Ye Yang, Jing Li, Sung-Hyun Park, Guang-Chen Fang, Chuan Liang, Weiguo Cao

Journal: DNA Repair (Amst)

PubMed ID: 36179537

Doi: 10.1016/j.dnarep.2022.103408

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Identification and functional analysis of histone 12-like in red sea bream (Pagrus major)

Authors: Lianfei Song, Maqsood Ahmed Soomro, Lingshu Wang, Yuting Song, Guobin Hu

Journal: Dev Comp Immunol

PubMed ID: 36087785

Doi: 10.1016/j.dci.2022.104529

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Characterization and Expression Analysis of Regeneration-Associated Protein (Aj-Orpin) during Intestinal Regeneration in the Sea Cucumber

Authors: Fang Su, Lina Sun, Xiaoni Li, Wei Cui, Hongsheng Yang

Journal: Mar Drugs

PubMed ID: 36135757

Doi: 10.3390/md20090568

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A member of the tryptophan-rich protein family is required for efficient sequestration of Plasmodium berghei schizonts

Authors: Julie-Anne Gabelich, Josephine Grützke, Florian Kirscht, Oliver Popp, Joachim M Matz, Gunnar Dittmar, Melanie Rug, Alyssa Ingmundson

Journal: PLoS Pathog

PubMed ID: 36126089

Doi: 10.1371/journal.ppat.1010846

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Molecular study on recombinant cold-adapted, detergent- and alkali stable esterase (EstRag) from Lysinibacillus sp.: a member of family VI.

Authors: Amira A Matrawy, Ahmed I Khalil, Amira M Embaby

Journal: World J Microbiol Biotechnol .

PubMed ID: 36070019

Doi: 10.1007/s11274-022-03402-5

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Arabidopsis Ubiquitin-Conjugating Enzymes UBC4, UBC5, and UBC6 Have Major Functions in Sugar Metabolism and Leaf Senescence

Authors: Sheng Wang , Ling Cao , Ian R Willick , Hong Wang , Karen K Tanino

Journal: Int J Mol Sci

PubMed ID: 36232444

Doi: ijms231911143

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HOXB13 facilitates hepatocellular carcinoma progression by activating AKT/mTOR signaling pathway

Authors: Miao Li, Tingting Tan, Yu Geng, Yue Tao, Jie Pan, Jun Zhang, Qin Xu, Han Shen, Lingyun Zuo, Yuxin Chen

Journal: Ann Hepatol

PubMed ID: 36179794

Doi: 10.1016/j.aohep.2022.100759

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Teaching an old 'doc' new tricks for algal biotechnology: Strategic filter use enables multi-scale fluorescent protein signal detection

Authors: Sergio Gutiérrez, Gordon B Wellman, Kyle J Lauersen

Journal: Front Bioeng Biotechnol

PubMed ID: 36213064

Doi: 10.3389/fbioe.2022.979607

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An investigation across 45 languages and 12 language families reveals a universal language network

Authors: Saima Malik-Moraleda, Dima Ayyash, Jeanne Gallée, Josef Affourtit, Malte Hoffmann, Zachary Mineroff, Olessia Jouravlev, Evelina Fedorenko

Journal: Nat Neurosci

PubMed ID: 35856094

Doi: 10.1038/s41593-022-01114-5

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In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM

Authors: Cheng-Yu Huang, Piotr Draczkowski, Yong-Sheng Wang, Chia-Yu Chang, Yu-Chun Chien, Yun-Han Cheng, Yi-Min Wu, Chun-Hsiung Wang, Yuan-Chih Chang, Yen-Chen Chang, Tzu-Jing Yang, Yu-Xi Tsai, Kay-Hooi Khoo, Hui-Wen Chang, Shang-Te Danny Hsu

Journal: Nat Commun

PubMed ID: 35986008

Doi: 10.1038/s41467-022-32588-3

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Safety and Humoral and Cellular Immunogenicity of the BNT162b2 SARS-CoV-2 Vaccine in Liver-Transplanted Adolescents Compared to Healthy Adolescents

Authors: Palittiya Sintusek, Supranee Buranapraditkun, Siriporn Khunsri, Varattaya Saengchaisukhonkit, Preeyaporn Vichaiwattana, Donchida Srimuan, Thanunrat Thongmee, Yong Poovorawan

Journal: Vaccines (Basel)

PubMed ID: 36016212

Doi: 10.3390/vaccines10081324

Reduced Sensitivity of Commercial Spike-Specific Antibody Assays after Primary Infection with the SARS-CoV-2 Omicron Variant

Authors: David Niklas Springer, Thomas Perkmann, Claudia Maria Jani, Patrick Mucher, Katja Prüger, Rodrig Marculescu, Elisabeth Reuberger, Jeremy Vann Camp, Marianne Graninger, Christian Borsodi, Josef Deutsch, Oliver Lammel, Stephan Walter Aberle, Elisabeth Puchhammer-Stöckl, Helmuth Haslacher, Eva Höltl, Judith Helene Aberle, Karin Stiasny, Lukas Weseslindtner

Journal: Microbiol Spectr

PubMed ID: 36005839

Doi: 10.1128/spectrum.02129-22

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Single-injection COVID-19 subunit vaccine elicits potent immune responses

Authors: Xiaoyong Zhou, Haozheng Wang, Ying Luo, Lei Cui, Ying Guan, Yongjun Zhang

Journal: Acta Biomater

PubMed ID: 35948176

Doi: 10.1016/j.actbio.2022.08.006

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Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses

Authors: Brandon McLeod, Moustafa T Mabrouk, Kazutoyo Miura, Rashmi Ravichandran, Sally Kephart, Sophia Hailemariam, Thao P Pham, Anthony Semesi, Iga Kucharska, Prasun Kundu, Wei-Chiao Huang, Max Johnson, Alyssa Blackstone, Deleah Pettie, Michael Murphy, John C Kraft, Elizabeth M Leaf, Yang Jiao, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Jordache Ramjith, C Richter King, Randall S MacGill, Yimin Wu, Kelly K Lee, Matthijs M Jore, Neil P King, Jonathan F Lovell, Jean-Philippe Julien

Journal: Immunity

PubMed ID: 35977542

Doi: 10.1016/j.immuni.2022.07.015

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miR-657 Targets SRCIN1 via the Slug Pathway to Promote NSCLC Tumor Growth and EMT Induction

Authors: Yingqian Zhang, Jiao Yuan, Mengfei Guo, Run Xiang, Xiang Wang, Tianpeng Xie, Xiang Zhuang, Qiang Li, Qi Lai

Journal: Dis Markers

PubMed ID: 36033827

Doi: 10.1155/2022/4842454

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Integrated AlphaFold2 and DEER investigation of the conformational dynamics of a pH-dependent APC antiporter

Authors: Diego Del Alamo, Lillian DeSousa, Rahul M Nair, Suhaila Rahman, Jens Meiler, Hassane S Mchaourab

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35969794

Doi: 10.1073/pnas.2206129119

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Extracellular expression of 's L-asparaginase II in results in novel enzyme with better parameters

Authors: Henrique P Biasoto, Cristina B Hebeda, Sandra H P Farsky, Adalberto Pessoa, Tales A Costa-Silva, Gisele Monteiro

Journal: Prep Biochem Biotechnol

PubMed ID: 35981094

Doi: 10.1080/10826068.2022.2111582

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Modulation of K43-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2

Authors: Angela de Benito-Bueno, Paula G Socuellamos, Yaiza G Merinero, Pilar Cercos, Carolina Izquierdo, Miguel Daniel-Mozo, Irene Marín-Olivero, Angel Perez-Lara, Juan A Gonzalez-Vera, Angel Orte, Armando Albert, Mercedes Martin-Martinez, Marta Gutierrez-Rodriguez, Carmen Valenzuela

Journal: Int J Mol Sci

PubMed ID: 36012438

Doi: 10.3390/ijms23169170

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PpZAT10 negatively regulates peach cold resistance predominantly mediated by inhibiting VIN activity

Authors: YiChen ,JiachangSun ,YingyingWei ,KefengCao ,ShuJiang ,XingfengShao

Journal: Postharvest Biology and Technology

Doi: 10.1016/j.postharvbio.2022.111952

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Non-viral，specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL

Authors: Jiqin Zhang , Yongxian Hu , Jiaxuan Yang , Wei Li , Mingming Zhang , Qingcan Wang , Linjie Zhang , Guoqing Wei , Yue Tian , Kui Zhao , Ang Chen , Binghe Tan , Jiazhen Cui , Deqi Li , Yi Li , Yalei Qi , Dongrui Wang , Yuxuan Wu , Dali Li , Bing Du , Mingyao Liu , He Huang

Journal: Nature

PubMed ID: 36045296

Doi: 10.1038/s41586-022-05140-y

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Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.

Authors: Zuben P Brown , Irina S Abaeva , Swastik De , Christopher U T Hellen , Tatyana V Pestova , Joachim Frank

Journal: EMBO J

PubMed ID: 35822879

Doi: 10.15252/embj.2022110581

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DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates

Authors: Lijie Zhao , Naizhe Huang , Jun Mencius , Yanjing Li , Ying Xu , Yongxin Zheng , Wei He , Na Li , Jun Zheng , Min Zhuang , Shu Quan , Yong Chen

Journal: iScience

PubMed ID: 36065180

Doi: 10.1016/j.isci.2022.104948

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A novel ZsGreen knock-in melanoma cell line reveals the function of CD11b in tumor phagocytosis

Authors: Lichen Zhang, Xinyu Feng, Yingzhuo Shen, Yingbin Wang, Zhuangzhuang Liu, Yuang Ma, Yanrong Gu, Guo Guo, Liangwei Duan, Liaoxun Lu, Yinming Liang, Toby Lawrence, Rong Huang

Journal: Immunol Cell Biol

PubMed ID: 35849045

Doi: 10.1111/imcb.12575

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Crucial role of Ca /CN signalling pathway in the antifungal activity of disenecioyl-cis-khellactone against Botrytis cinerea

Authors: Ping-Ping Song, Yu Wang, Yi-Ping Hou, Xue-Wei Mao, Zong-Liang Liu, Min Wei, Jin-Ping Yu, Bi Wang, Yi-Yun Qian, Lu Yan, Shu Xu, Yan-Qin Jiang, Dong-Qin Zhou, Min Yin, Jian Dou

Journal: Pest Manag Sci

PubMed ID: 35866518

Doi: 10.1002/ps.7085

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Tripeptide Leu-Pro-Phe from Corn Protein Hydrolysates Attenuates Hyperglycemia-Induced Neural Tube Defect in Chicken Embryos

Authors: Chang-Yu Yan, Jie Sun, Gui-Yuan Yu, Jiang-Han-Zi Liu, Rong-Ping Huang, Shao-Cong Han, Qiong-Yi Zhang, Xiao-Min Li, Jian-Gang Yan, Hiroshi Kurihara, Wei-Xi Li, Yi-Fang Li, Rong-Rong He

Journal: Oxid Med Cell Longev

PubMed ID: 36071868

Doi: 10.1155/2022/4932304

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Conjugation of the 9-kDa Isoform of Granulysin with Liposomes Potentiates Its Cytotoxicity

Authors: Ruth Soler-Agesta, Patricia Guerrero-Ochoa, Joaquín Marco-Brualla, Raquel Ibáñez-Pérez, Isabel Marzo, Luis Martínez-Lostao, Alberto Anel

Journal: Int J Mol Sci

PubMed ID: 35955839

Doi: 10.3390/ijms23158705

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3D bioprinting of in situ vascularized tissue engineered bone for repairing large segmental bone defects

Authors: Mingkui Shen, Lulu Wang, Yi Gao, Li Feng, Chuangye Xu, Sijing Li, Xiaohu Wang, Yulan Wu, Yao Guo, Guoxian Pei

Journal: Mater Today Bio

PubMed ID: 36033373

Doi: 10.1016/j.mtbio.2022.100382

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Enhancement of BCAT2-Mediated Valine Catabolism Stimulates β-Casein Synthesis via the AMPK-mTOR Signaling Axis in Bovine Mammary Epithelial Cells

Authors: Xinling Wang, Jie Xu, Hanfang Zeng, Zhaoyu Han

Journal: J Agric Food Chem

PubMed ID: 35916279

Doi: 10.1021/acs.jafc.2c03629

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IL-22 and Lactobacillus delbrueckii mitigate alcohol-induced exacerbation of DSS-induced colitis

Authors: Abigail R Cannon, Esther H Shim, Paulius V Kuprys, Mashkoor A Choudhry

Journal: J Leukoc Biol

PubMed ID: 35916052

Doi: 10.1002/JLB.4A0122-068R

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GAPDH mediates plant reovirus-induced incomplete autophagy for persistent viral infection in leafhopper vector

Authors: Qian Chen, Yuele Zhang, Hengsong Yang, Xin Wang, Jiping Ren, Dongsheng Jia, Hongyan Chen, Taiyun Wei

Journal: Autophagy

PubMed ID: 36036160

Doi: 10.1080/15548627.2022.2115830

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Conformational buffering underlies functional selection in intrinsically disordered protein regions

Authors: Nicolás S González-Foutel, Juliana Glavina, Wade M Borcherds, Matías Safranchik, Susana Barrera-Vilarmau, Amin Sagar, Alejandro Estaña, Amelie Barozet, Nicolás A Garrone, Gregorio Fernandez-Ballester, Clara Blanes-Mira, Ignacio E Sánchez, Gonzalo de Prat-Gay, Juan Cortés, Pau Bernadó, Rohit V Pappu, Alex S Holehouse, Gary W Daughdrill, Lucía B Chemes

Journal: Nat Struct Mol Biol

PubMed ID: 35948766

Doi: 10.1038/s41594-022-00811-w

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Identification of linear epitopes and their major role in the immunoglobulin E-binding capacity of tropomyosin from

Authors: Nai-Ru Ji, Xin-Yu Han, Chen-Chen Yu, Xin-Rong He, Shi-Tao Rao, Fei Huan, Hong Liu, Gui-Xia Chen, Min-Jie Cao, Guang-Ming Liu

Journal: Food Funct

PubMed ID: 35943407

Doi: 10.1039/d2fo01713j

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AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling

Authors: Renata Ferrarotto, Vasudha Mishra, Elad Herz, Adar Yaacov, Oz Solomon, Rami Rauch, Adi Mondshine, Maria Motin, Tal Leibovich-Rivkin, Matti Davis, Joel Kaye, Christopher R Weber, Le Shen, Alexander T Pearson, Ari J Rosenberg, Xiangying Chen, Alka Singh, Jon C Aster, Nishant Agrawal, Evgeny Izumchenko

Journal: Cell Death Dis

PubMed ID: 35931701

Doi: 10.1038/s41419-022-05133-9

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Oral glucagon-like peptide 1 analogue ameliorates glucose intolerance in db/db mice

Authors: Hanlin Zhang, Meng Dong, Shouli Yuan, Wanzhu Jin

Journal: Biotechnol Lett

PubMed ID: 36006576

Doi: 10.1007/s10529-022-03288-1

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Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain

Authors: Jing-Yi Zhou, Rui-Rui Yang, Jie Chang, Jia Song, Zi-Sheng Fan, Ying-Hui Zhang, Cheng-Hao Lu, Hua-Liang Jiang, Ming-Yue Zheng, Su-Lin Zhang

Journal: Acta Pharmacol Sin

PubMed ID: 35918411

Doi: 10.1038/s41401-022-00936-0

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A Localized Materials-Based Strategy to Non-Virally Deliver Chondroitinase ABC mRNA Improves Hindlimb Function in a Rat Spinal Cord Injury Model

Authors: Andrew S Khalil, Daniel Hellenbrand, Kaitlyn Reichl, Jennifer Umhoefer, Mallory Filipp, Joshua Choe, Amgad Hanna, William L Murphy

Journal: Adv Healthc Mater

PubMed ID: 35882512

Doi: 10.1002/adhm.202200206

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KIF20A promotes the development of fibrosarcoma via PI3K-Akt signaling pathway

Authors: Zheng Jin, Shuang Tao, Chao Zhang, Damo Xu, Zhenhua Zhu

Journal: Exp Cell Res

PubMed ID: 36037925

Doi: 10.1016/j.yexcr.2022.113322

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Pericentrin interacts with Kinesin-1 to drive centriole motility

Authors: Matthew R Hannaford, Rong Liu, Neil Billington, Zachary T Swider, Brian J Galletta, Carey J Fagerstrom, Christian Combs, James R Sellers, Nasser M Rusan

Journal: J Cell Biol

PubMed ID: 35929834

Doi: 10.1083/jcb.202112097

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Antibody affinity and cross-variant neutralization of SARS-CoV-2 Omicron BA1, BA2 and BA3 following third mRNA vaccination

Authors: Lorenza Bellusci, Gabrielle Grubbs, Fatema Tuz Zahra, David Forgacs, Hana Golding, Ted M Ross, Surender Khurana

Journal: Nat Commun

PubMed ID: 35941152

Doi: 10.1038/s41467-022-32298-w

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Third Early "Booster" Dose Strategy in France of bnt162b2 SARS-CoV-2 Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients Enhances Neutralizing Antibody Responses

Authors: Abdelhakim Ahmed-Belkacem, Rabah Redjoul, Rozenn Brillet, Nazim Ahnou, Mathieu Leclerc, Dennis Salomón López-Molina, Alexandre Soulier, Aurélie Gourgeon, Christophe Rodriguez, Sébastien Maury, Jean-Michel Pawlotsky, Slim Fourati

Journal: Viruses

PubMed ID: 36146735

Doi: 10.3390/v14091928

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The effect of substance P and its common in vivo-formed metabolites on MRGPRX2 and human mast cell activation

Authors: Lin Hsin, Nithya A Fernandopulle, Jie Ding, Chris Lumb, Nicholas Veldhuis, John A Karas, Susan E Northfield, Graham A Mackay

Journal: Pharmacol Res Perspect

PubMed ID: 35904495

Doi: 10.1002/prp2.990

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Expanding the antiviral potential of the mosquito lipid-transfer protein AEG12 against SARS-CoV-2 using hydrophobic antiviral ligands

Authors: Alexander C Y Foo, Bernard A P Lafont, Geoffrey A Mueller

Journal: FEBS Lett

PubMed ID: 35891619

Doi: 10.1002/1873-3468.14456

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Validation of a Novel Fluorescent Lateral Flow Assay for Rapid Qualitative and Quantitative Assessment of Total Anti-SARS-CoV-2 S-RBD Binding Antibody Units (BAU) from Plasma or Fingerstick Whole-Blood of COVID-19 Vaccinees

Authors: Nadin Younes, Duaa W Al-Sadeq, Farah M Shurrab, Hadeel T Zedan, Haissam Abou-Saleh, Bushra Y Abo-Halawa, Fatima M AlHamaydeh, Amira E Elsharafi, Hanin I Daas, Swapna Thomas, Sahar Aboalmaaly, Afra Al Farsi, Reeham Al-Buainain, Samar Ataelmannan, Jiji Paul, Amana Salih Al Saadi, Hadi M Yassine, Amin F Majdalawieh, Ahmed Ismail, Laith J Abu-Raddad, Gheyath K Nasrallah

Journal: Vaccines (Basel)

PubMed ID: 36016206

Doi: 10.3390/vaccines10081318

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Significance of lncRNA CDKN2B-AS1 in Interventional Therapy of Liver Cancer and the Mechanism under Its Participation in Tumour Cell Growth via miR-199a-5p

Authors: Lu Xu, Haotian Wu, Jianhua Pan, Zhiheng Chen, Linan Du

Journal: J Oncol

PubMed ID: 36081669

Doi: 10.1155/2022/2313416

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D-Lactic Acid Production from Sugarcane Bagasse by Genetically Engineered

Authors: Warasirin Sornlek, Kittapong Sae-Tang, Akaraphol Watcharawipas, Sriwan Wongwisansri, Sutipa Tanapongpipat, Lily Eurwilaichtr, Verawat Champreda, Weerawat Runguphan, Peter J Schaap, Vitor A P Martins Dos Santos

Journal: J Fungi (Basel)

PubMed ID: 36012804

Doi: 10.3390/jof8080816

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Sappanone a prevents diabetic kidney disease by inhibiting kidney inflammation and fibrosis the NF-κB signaling pathway

Authors: Zhe Wang, Zhida Chen, Xinyi Wang, Yepeng Hu, Jing Kong, Jiabin Lai, Tiekun Li, Bibi Hu, Yikai Zhang, Xianan Zheng, Xiaoxian Liu, Shengyao Wang, Shu Ye, Qiao Zhou, Chao Zheng

Journal: Front Pharmacol

PubMed ID: 36052141

Doi: 10.3389/fphar.2022.953004

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Repression of linc01555 up-regulates angiomotin-p130 via the microRNA-122-5p/clic1 axis to impact vasculogenic mimicry-mediated chemotherapy resistance in small cell lung cancer

Authors: Dan Li, YanWei Shen, Hui Ren, Li Wang, Jin Yang, Yuan Wang

Journal: Cell Cycle

PubMed ID: 36045598

Doi: 10.1080/15384101.2022.2112132

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Transcriptomic and Phenotypic Analysis of CRISPR/Cas9-Mediated Knockout in Zebrafish

Authors: Qianqian Yan, Wenhao Li, Xiaoting Gong, Ruiqin Hu, Liangbiao Chen

Journal: Genes (Basel)

PubMed ID: 36011351

Doi: 10.3390/genes13081441

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Endothelial Cell Infection by Guinea Pig Cytomegalovirus Is a Lytic or Persistent Infection Depending on Tissue Origin but Requires Viral Pentamer Complex and pp65 Tegument Protein

Authors: K Yeon Choi, Nadia El-Hamdi, Alistair McGregor

Journal: J Virol

PubMed ID: 36000848

Doi: 10.1128/jvi.00831-22

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The NCF1 variant pR90H aggravates autoimmunity by facilitating the activation of plasmacytoid dendritic cells

Authors: Yao Meng, Jianyang Ma, Chao Yao, Zhizhong Ye, Huihua Ding, Can Liu, Jun Li, Guanhua Li, Yuke He, Jia Li, Zhihua Yin, Li Wu, Haibo Zhou, Nan Shen

Journal: J Clin Invest

PubMed ID: 35788118

Doi: 10.1172/JCI153619

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Novel prime-boost immune-based therapy inhibiting both hepatitis B and D virus infections

Authors: Rani Burm, Panagiota Maravelia, Gustaf Ahlen, Sandra Ciesek, Noelia Caro Perez, Anna Pasetto, Stephan Urban, Freya Van Houtte, Lieven Verhoye, Heiner Wedemeyer, Magnus Johansson, Lars Frelin, Matti Sällberg, Philip Meuleman

Journal: Gut

PubMed ID: 35977815

Doi: 10.1136/gutjnl-2022-327216

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mmu-microRNA-92a-3p attenuates pulmonary fibrosis by modulating Cpeb4-mediated Smad2/3 signaling pathway

Authors: Mengkun Shi, Huixia Cui, Jialun Shi, Yunqing Mei

Journal: Funct Integr Genomics

PubMed ID: 35909199

Doi: 10.1007/s10142-022-00879-z

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Genome of Uncovers an Extensive Arsenal of Virulence-Related Genes among the Broad-Host-Range Necrotrophic Plant Pathogens

Authors: Paul Daly, Dongmei Zhou, Danyu Shen, Yifan Chen, Taiqiang Xue, Siqiao Chen, Qimeng Zhang, Jinfeng Zhang, Jamie McGowan, Feng Cai, Guan Pang, Nan Wang, Taha Majid Mahmood Sheikh, Sheng Deng, Jingjing Li, Hüseyin Okan Soykam, Irem Kara, David A Fitzpatrick, Irina S Druzhinina, Günseli Bayram Akcapinar, Lihui Wei

Journal: Microbiol Spectr

PubMed ID: 35946960

Doi: 10.1128/spectrum.02268-21

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Sall4 guides p53-mediated enhancer interference upon DNA damage in mouse embryonic stem cells

Authors: Lei Wang, Xiaojun Tan, Lu Chen, Sisi Xu, Weiping Huang, Nan Chen, Yizhou Wu, Chunyan Wang, Daqiang Zhou, Mangmang Li

Journal: Stem Cells

PubMed ID: 35977539

Doi: 10.1093/stmcls/sxac058

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Rotavirus Spike Protein VP4 Mediates Viroplasm Assembly by Association to Actin Filaments

Authors: Janine Vetter, Guido Papa, Michael Seyffert, Kapila Gunasekera, Giuditta De Lorenzo, Mahesa Wiesendanger, Jean-Louis Reymond, Cornel Fraefel, Oscar R Burrone, Catherine Eichwald

Journal: J Virol

PubMed ID: 35938869

Doi: 10.1128/jvi.01074-22

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Safety and Immunogenicity of an Inactivated Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine in a Subgroup of Healthy Adults in Chile

Authors: Susan M Bueno, Katia Abarca, Pablo A González, Nicolás M S Gálvez, Jorge A Soto, Luisa F Duarte, Bárbara M Schultz, Gaspar A Pacheco, Liliana A González, Yaneisi Vázquez, Mariana Ríos, Felipe Melo-González, Daniela Rivera-Pérez, Carolina Iturriaga, Marcela Urzúa, Angélica Domínguez, Catalina A Andrade, Roslye V Berríos-Rojas, Gisela Canedo-Marroquín, Camila Covián, Daniela Moreno-Tapia, Farides Saavedra, Omar P Vallejos, Paulina Donato, Pilar Espinoza, Daniela Fuentes, Marcela González, Paula Guzmán, Paula Muñoz Venturelli, Carlos M Pérez, Marcela Potin, Álvaro Rojas, Rodrigo A Fasce, Jorge Fernández, Judith Mora, Eugenio Ramírez, Aracelly Gaete-Argel, Aarón Oyarzún-Arrau, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Daniela Weiskopf, Alessandro Sette, Gang Zeng, Weining Meng, José V González-Aramundiz, Alexis M Kalergis

Journal: Clin Infect Dis

PubMed ID: 34537835

Doi: 10.1093/cid/ciab823

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Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus

Authors: Maya Sangesland, Alba Torrents de la Peña, Seyhan Boyoglu-Barnum, Larance Ronsard, Faez Amokrane Nait Mohamed, Thalia Bracamonte Moreno, Ralston M Barnes, Daniel Rohrer, Nils Lonberg, Musie Ghebremichael, Masaru Kanekiyo, Andrew Ward, Daniel Lingwood

Journal: Immunity

PubMed ID: 35952670

Doi: 10.1016/j.immuni.2022.07.006

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KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis

Authors: Loka R Penke, Jennifer M Speth, Steven K Huang, Sean M Fortier, Jared Baas, Marc Peters-Golden

Journal: JCI Insight

PubMed ID: 35852857

Doi: 10.1172/jci.insight.160688

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Ascl1 phospho-site mutations enhance neuronal conversion of adult cortical astrocytes

Authors: Hussein Ghazale, EunJee Park, Lakshmy Vasan, James Mester, Fermisk Saleh, Andrea Trevisiol, Dawn Zinyk, Vorapin Chinchalongporn, Mingzhe Liu, Taylor Fleming, Oleksandr Prokopchuk, Natalia Klenin, Deborah Kurrasch, Maryam Faiz, Bojana Stefanovic, JoAnne McLaurin, Carol Schuurmans

Journal: Front Neurosci

PubMed ID: 36061596

Doi: 10.3389/fnins.2022.917071

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SARS-CoV-2 Omicron BA1 and BA2 are attenuated in rhesus macaques as compared to Delta

Authors: Neeltje van Doremalen, Manmeet Singh, Taylor A Saturday, Claude Kwe Yinda, Lizzette Perez-Perez, W Forrest Bohler, Zachary A Weishampel, Matthew Lewis, Jonathan E Schulz, Brandi N Williamson, Kimberly Meade-White, Shane Gallogly, Atsushi Okumura, Friederike Feldmann, Jamie Lovaglio, Patrick W Hanley, Carl Shaia, Heinz Feldmann, Emmie de Wit, Vincent J Munster, Kyle Rosenke

Journal: biorxiv

PubMed ID: 35971544

Doi: 10.1101/2022.08.01.502390

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Dengue Virus NS4b N-Terminus Disordered Region Interacts with NS3 Helicase C-Terminal Subdomain to Enhance Helicase Activity

Authors: Satyamurthy Kundharapu, Tirumala Kumar Chowdary

Journal: Viruses

PubMed ID: 36016333

Doi: 10.3390/v14081712

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RASA2 ablation in T cells boosts antigen sensitivity and long-term function

Authors: Julia Carnevale, Eric Shifrut, Nupura Kale, William A Nyberg, Franziska Blaeschke, Yan Yi Chen, Zhongmei Li, Sagar P Bapat, Morgan E Diolaiti, Patrick O'Leary, Shane Vedova, Julia Belk, Bence Daniel, Theodore L Roth, Stefanie Bachl, Alejandro Allo Anido, Brooke Prinzing, Jorge Ibañez-Vega, Shannon Lange, Dalia Haydar, Marie Luetke-Eversloh, Maelys Born-Bony, Bindu Hegde, Scott Kogan, Tobias Feuchtinger, Hideho Okada, Ansuman T Satpathy, Kevin Shannon, Stephen Gottschalk, Justin Eyquem, Giedre Krenciute, Alan Ashworth, Alexander Marson

Journal: Nature

PubMed ID: 36002574

Doi: 10.1038/s41586-022-05126-w

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Engineering cell morphology by CRISPR interference in Acinetobacter baylyi ADP1

Authors: Jin Luo, Elena Efimova, Daniel Christoph Volke, Ville Santala, Suvi Santala

Journal: Microb Biotechnol

PubMed ID: 36005297

Doi: 10.1111/1751-7915.14133

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CRISPR-Cas9-directed gene tagging using a single integrase-defective lentiviral vector carrying a transposase-based Cas9 off switch

Authors: Emil Aagaard Thomsen, Kristian Alsbjerg Skipper, Sofie Andersen, Didde Haslund, Thomas Wisbech Skov, Jacob Giehm Mikkelsen