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a New IFN-Inducible Human Member of the Ly6a Subfamily Expressed by Spleen Cells and Associated with Inflammation and Viral Resistance

Authors: Moriya Shmerling, Michael Chalik, Nechama I Smorodinsky, Alan Meeker, Sujayita Roy, Orit Sagi-Assif, Tsipi Meshel, Artem Danilevsky, Noam Shomron, Shmuel Levinger, Bar Nishry, David Baruchi, Avital Shargorodsky, Ravit Ziv, Avital Sarusi-Portuguez, Maoz Lahav, Marcelo Ehrlich, Bryony Braschi, Elspeth Bruford, Isaac P Witz, Daniel H Wreschner

Journal: Immunohorizons

PubMed ID: 35440514

Doi: 10.4049/immunohorizons.2200018

Products & Services: DNA Sequencing

A Bacterially Expressed SARS-CoV-2 Receptor Binding Domain Fused With Cross-Reacting Material 197 A-Domain Elicits High Level of Neutralizing Antibodies in Mice

Authors: Liqin Liu, Tingting Chen, Lizhi Zhou, Jie Sun, Yuqian Li, Meifeng Nie, Hualong Xiong, Yuhe Zhu, Wenhui Xue, Yangtao Wu, Tingting Li, Tianying Zhang, Zhibo Kong, Hai Yu, Jun Zhang, Ying Gu, Qingbing Zheng, Qinjian Zhao, Ningshao Xia, Shaowei Li

Journal: Front Microbiol

PubMed ID: 35558112

Doi: 10.3389/fmicb.2022.854630

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Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but moderately reduced lung inflammation

Authors: Koen K A Van Rompay, Katherine J Olstad, Rebecca L Sammak, Joseph Dutra, Jennifer K Watanabe, Jodie L Usachenko, Ramya Immareddy, Jamin W Roh, Anil Verma, Yashavanth Shaan Lakshmanappa, Brian A Schmidt, Clara Di Germanio, Nabeela Rizvi, Hongwei Liu, Zhong-Min Ma, Mars Stone, Graham Simmons, Larry J Dumont, A Mark Allen, Sarah Lockwood, Rachel E Pollard, Rafael Ramiro de Assis, JoAnn L Yee, Peter B Nham, Amir Ardeshir, Jesse D Deere, Aarti Jain, Philip L Felgner, Lark L Coffey, Smita S Iyer, Dennis J Hartigan-O'Connor, Michael P Busch, J Rachel Reader

Journal: PLoS Pathog

PubMed ID: 35443018

Doi: 10.1371/journal.ppat.1009925

Products & Services: Recombinant Antibody Expression

Formulation of simvastatin within high density lipoprotein enables potent tumour radiosensitisation

Authors: Pouya Dehghankelishadi, Michelle F Maritz, Nicole Dmochowska, Parisa Badiee, Edward Cheah, Ivan Kempson, Ross I Berbeco, Benjamin Thierry

Journal: J Control Release

PubMed ID: 35447296

Doi: 10.1016/j.jconrel.2022.04.017

Products & Services: Peptide Synthesis

Cathepsin B-Cleavable Polymeric Photosensitizer Prodrug for Selective Photodynamic Therapy: In Vitro Studies

Authors: Manish Jain, Jordan Bouilloux, Ines Borrego, Stéphane Cook, Hubert van den Bergh, Norbert Lange, Georges Wagnieres, Marie-Noelle Giraud

Journal: Pharmaceuticals (Basel)

PubMed ID: 35631388

Doi: 10.3390/ph15050564

Products & Services: Biochemicals

Tuning the Sensitivity of Genetically Encoded Fluorescent Potassium Indicators through Structure-Guided and Genome Mining Strategies

Authors: Cristina C Torres Cabán, Minghan Yang, Cuixin Lai, Lina Yang, Fedor V Subach, Brian O Smith, Kiryl D Piatkevich, Edward S Boyden

Journal: ACS Sens

PubMed ID: 35427452

Doi: 10.1021/acssensors.1c02201

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Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway

Authors: Xiaofang Wei, Juan Tan, Hui Gao

Journal: Bioengineered

PubMed ID: 35383535

Doi: 10.1080/21655979.2022.2060626

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Thermodynamically coupled biosensors for detecting neutralizing antibodies against SARS-CoV-2 variants

Authors: Jason Z Zhang, Hsien-Wei Yeh, Alexandra C Walls, Basile I M Wicky, Kaitlin R Sprouse, Laura A VanBlargan, Rebecca Treger, Alfredo Quijano-Rubio, Minh N Pham, John C Kraft, Ian C Haydon, Wei Yang, Michelle DeWitt, John E Bowen, Cameron M Chow, Lauren Carter, Rashmi Ravichandran, Mark H Wener, Lance Stewart, David Veesler, Michael S Diamond, Alexander L Greninger, David M Koelle, David Baker

Journal: Nat Biotechnol

PubMed ID: 35484405

Doi: 10.1038/s41587-022-01280-8

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A third dose of mRNA-1273 vaccine improves SARS-CoV-2 immunity in HCT recipients with low antibody response after 2 doses

Authors: Elena Pettini, Annalisa Ciabattini, Gabiria Pastore, Jacopo Polvere, Simone Lucchesi, Fabio Fiorino, Francesca Montagnani, Alessandro Bucalossi, Monica Tozzi, Giuseppe Marotta, Donata Medaglini

Journal: Blood Adv

PubMed ID: 35073574

Doi: 10.1182/bloodadvances.2021006599

The recombinant defensin/HSA fusion protein that inhibits NF-κb associated with intensive macropinocytosis shows potent efficacy against pancreatic cancer

Authors: Yi-Bo Du, Xiao-Fei Wang, Xiu-Jun Liu, Yi Li, Qing-Fang Miao, Min Jiang, Wei-Jin Sheng, Yong-Su Zhen

Journal: Biochem Pharmacol

PubMed ID: 35489393

Doi: 10.1016/j.bcp.2022.115057

Products & Services: Recombinant Antibody Expression

Functional differentiation of three pheromone binding proteins in Orthaga achatina using mixed-type sex pheromones

Authors: Yu-Xiao Si, Jin-Meng Guo, Hui Liao, Yu Li, Yu Ma, Yu-Wei Zhu, Zhi-Qiang Wei, Shuang-Lin Dong, Qi Yan

Journal: Pestic Biochem Physiol

PubMed ID: 35715036

Doi: 10.1016/j.pestbp.2022.105097

Products & Services: Proteins, Expression, Isolation and Analysis

Hypomethylation-mediated upregulation of the WASF2 promoter region correlates with poor clinical outcomes in hepatocellular carcinoma

Authors: Hye Ri Ahn, Geum Ok Baek, Moon Gyeong Yoon, Ju A Son, Jung Hwan Yoon, Jae Youn Cheong, Hyo Jung Cho, Ho Chul Kang, Jung Woo Eun, Soon Sun Kim

Journal: J Exp Clin Cancer Res

PubMed ID: 35477411

Doi: 10.1186/s13046-022-02365-7

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A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis

Authors: Lei Zhang, James E Kent, Meredith Whitaker, David C Young, Dominik Herrmann, Alexander E Aleshin, Ying-Hui Ko, Gino Cingolani, Jamil S Saad, D Branch Moody, Francesca M Marassi, Sabine Ehrt, Michael Niederweis

Journal: Nat Commun

PubMed ID: 35474308

Doi: 10.1038/s41467-022-29873-6

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L-tyrosine-bound ThiH structure reveals C-C bond break differences within radical SAM aromatic amino acid lyases

Authors: Patricia Amara, Claire Saragaglia, Jean-Marie Mouesca, Lydie Martin, Yvain Nicolet

Journal: Nat Commun

PubMed ID: 35477710

Doi: 10.1038/s41467-022-29980-4

Products & Services: Codon Optimization

C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Carbapenemase OXA-23 by Impeding Deacylation

Authors: Nichole K Stewart, Marta Toth, Maha A Alqurafi, Weirui Chai, Thu Q Nguyen, Pojun Quan, Mijoon Lee, John D Buynak, Clyde A Smith, Sergei B Vakulenko

Journal: MBio

PubMed ID: 35420470

Doi: 10.1128/mbio.00367-22

Products & Services: PCR Cloning and Subcloning

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B11529

Authors: Tongqing Zhou, Lingshu Wang, John Misasi, Amarendra Pegu, Yi Zhang, Darcy R Harris, Adam S Olia, Chloe Adrienna Talana, Eun Sung Yang, Man Chen, Misook Choe, Wei Shi, I-Ting Teng, Adrian Creanga, Claudia Jenkins, Kwanyee Leung, Tracy Liu, Erik-Stephane D Stancofski, Tyler Stephens, Baoshan Zhang, Yaroslav Tsybovsky, Barney S Graham, John R Mascola, Nancy J Sullivan, Peter D Kwong

Journal: Science

PubMed ID: 35324257

Doi: 10.1126/science.abn8897

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Neutralization of Myotoxin II, a Phospholipase A Homologue from Venom, Using Peptides Discovered via Phage Display Technology

Authors: Andreas H Laustsen, Bengt H Gless, Timothy P Jenkins, Maria Meyhoff-Madsen, Johanna Bjärtun, Andreas S Munk, Saioa Oscoz, Julián Fernández, José María Gutiérrez, Bruno Lomonte, Brian Lohse

Journal: ACS Omega

PubMed ID: 35571794

Doi: 10.1021/acsomega.2c00280

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Targeting kinesin family member 21B by miR-132-3p represses cell proliferation, migration and invasion in gastric cancer

Authors: Bingtian Liu, Ling Qiang, Bingxin Guan, Zhipeng Ji

Journal: Bioengineered

PubMed ID: 35341446

Doi: 10.1080/21655979.2022.2054755

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Mitochondrial micropeptide STMP1 promotes G1/S transition by enhancing mitochondrial complex IV activity

Authors: Ye Sang, Jin-Yu Liu, Feng-Yi Wang, Xiao-Yu Luo, Zi-Qi Chen, Shi-Mei Zhuang, Ying Zhu

Journal: Mol Ther

PubMed ID: 35450818

Doi: 10.1016/j.ymthe.2022.04.012

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Hapten-labeled fusion-polymerase chain reaction of multiple marker genes for the application of immunochromatographic test

Authors: Atsushi Tabata, Rina Shirai, Haruka Miki, Yukihiro Nishikawa, Tatsuya Kashima, Tomomi Aoyama, Shu Murakami, Momoyo Azuma, Toshifumi Tomoyasu, Hideaki Nagamune

Journal: J Biosci Bioeng

PubMed ID: 35450786

Doi: 10.1016/j.jbiosc.2022.03.006

Products & Services: Plasmid DNA Preparation

Identifying Small-Molecule Inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase by Establishing a Fluorometric Assay

Authors: Xiaoming Bai, Hongmin Sun, Shuo Wu, Yuhuan Li, Lifei Wang, Bin Hong

Journal: Front Immunol

PubMed ID: 35464436

Doi: 10.3389/fimmu.2022.844749

Products & Services: Recombinant Antibody Expression

Conserved metabolic enzymes as vaccine antigens for giardiasis

Authors: Sozaburo Ihara, Yukiko Miyamoto, Christine H Y Le, Vivien N Tran, Elaine M Hanson, Marvin Fischer, Kurt Hanevik, Lars Eckmann

Journal: PLoS Negl Trop Dis

PubMed ID: 35468132

Doi: 10.1371/journal.pntd.0010323

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Armet from whitefly saliva acts as an effector to suppress plant defences by targeting tobacco cystatin

Authors: Hui Du, Hong-Xing Xu, Fang Wang, Li-Xin Qian, Shu-Sheng Liu, Xiao-Wei Wang

Journal: New Phytol

PubMed ID: 35238409

Doi: 10.1111/nph.18063

Products & Services: Proteins, Expression, Isolation and Analysis

Biomimetic biphasic curdlan-based scaffold for osteochondral tissue engineering applications - Characterization and preliminary evaluation of mesenchymal stem cell response in vitro

Authors: Katarzyna Klimek, Aleksandra Benko, Marta Vandrovcova, Martina Travnickova, Timothy E L Douglas, Marta Tarczynska, Antonin Broz, Krzysztof Gaweda, Grazyna Ginalska, Lucie Bacakova

Journal: Biomater Adv

PubMed ID: 35929204

Doi: 10.1016/j.bioadv.2022.212724

Products & Services: Mammalian Expression

SARS-CoV-2 nsp5 Exhibits Stronger Catalytic Activity and Interferon Antagonism than Its SARS-CoV Ortholog

Authors: Jiyao Chen, Zhuang Li, Jiahui Guo, Shangen Xu, Junwei Zhou, Qian Chen, Xue Tong, Dang Wang, Guiqing Peng, Liurong Fang, Shaobo Xiao

Journal: J Virol

PubMed ID: 35389264

Doi: 10.1128/jvi.00037-22

Products & Services: Proteins, Expression, Isolation and Analysis

Structural characterization of a dimerization interface in the CD28 transmembrane domain

Authors: Hongyi Wu, Ruiyu Cao, Maorong Wen, Hongjuan Xue, Bo OuYang

Journal: Structure

PubMed ID: 35397202

Doi: 10.1016/j.str.2022.03.004

Products & Services: GenParts™ DNA Fragments

Multiple Polypyrimidine Tract Elements Regulate a Cooperative Mechanism for Triticum Mosaic Virus Internal Ribosomal Entry Site Activity

Authors: Helena Jaramillo-Mesa, Emma Fischer, Aurélie M Rakotondrafara

Journal: Front Plant Sci

PubMed ID: 35498652

Doi: 10.3389/fpls.2022.864832

Products & Services: Molecular Biology Reagents

Evaluation of biotransformation capacity of transplastomic plants and hairy roots of Nicotiana tabacum expressing human cytochrome P450 2D6

Authors: Y V Sheludko, I M Gerasymenko, F J Herrmann, H Warzecha

Journal: Transgenic Res

PubMed ID: 35416604

Doi: 10.1007/s11248-022-00305-x

Products & Services: Codon Optimization

Production of interferon gamma and interleukin 17A in chicken T-cell subpopulations hallmarks the stimulation with live, irradiated and killed avian pathogenic Escherichia coli

Authors: Sina Bagheri, Surya Paudel, Viskam Wijewardana, Richard Thiga Kangethe, Giovanni Cattoli, Michael Hess, Dieter Liebhart, Taniya Mitra

Journal: Dev Comp Immunol

PubMed ID: 35390358

Doi: 10.1016/j.dci.2022.104408

Products & Services: Molecular Biology Tools

A Recombinant Turkey Herpesvirus Expressing the F Protein of Newcastle Disease Virus Genotype XII Generated by NHEJ-CRISPR/Cas9 and Cre-LoxP Systems Confers Protection against Genotype XII Challenge in Chickens

Authors: Katherine Calderón, Aldo Rojas-Neyra, Brigith Carbajal-Lévano, Luis Luján-Valenzuela, Julio Ticona, Gisela Isasi-Rivas, Angela Montalvan, Manuel Criollo-Orozco, Edison Huaccachi-Gonzáles, Luis Tataje-Lavanda, Karla Lucia F Alvarez, Manolo Fernández-Sánchez, Manolo Fernández-Díaz, Na Tang, Yongxiu Yao, Venugopal Nair

Journal: Viruses

PubMed ID: 35458523

Doi: 10.3390/v14040793

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Circ_0047921 acts as the sponge of miR-1287-5p to stimulate lung cancer progression by regulating proliferation, migration, invasion, and glycolysis of lung cancer cells

Authors: Yuehua Xiao, Shequn Gu, Wenxiu Yao, Ling Qin, Jihui Luo

Journal: World J Surg Oncol

PubMed ID: 35365169

Doi: 10.1186/s12957-021-02466-1

Products & Services: Recombinant Proteins

Monoclonal antibody 7H22 binds the C-terminus of the cancer-oocyte antigen SAS1B through the hydrophilic face of a conserved amphipathic helix corresponding to one of only two regions predicted to be ordered

Authors: Max S G Legg, Susannah M L Gagnon, Cameron J Powell, Martin J Boulanger, Andra J J Li, Stephen V Evans

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35503210

Doi: 10.1107/S2059798322003011

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High-yield overproduction and purification of human aquaporins from

Authors: Tamim Al-Jubair, Jonas Hyld Steffen, Julie Winkel Missel, Philip Kitchen, Mootaz M Salman, Roslyn M Bill, Pontus Gourdon, Susanna Törnroth-Horsefield

Journal: STAR Protoc

PubMed ID: 35463467

Doi: 10.1016/j.xpro.2022.101298

Products & Services: Gene Synthesis

Immunogenicity and safety of homologous and heterologous ChAdOx1-S and mRNA-1273 vaccinations in healthy adults in Taiwan

Authors: Chun-Min Kang, Nan-Yao Lee, Chih-Hsueh Lin, Yuan-Shan Hsu, Yu-Chang Chang, Ming-Yi Chung, Ya-Fan Lee, Wen-Pin Tseng, Jhong-Lin Wu, Shey-Ying Chen, Min-Chi Lu, Wen-Chien Ko, Ping-Ing Lee, Po-Ren Hsueh

Journal: J Clin Virol

PubMed ID: 35413588

Doi: 10.1016/j.jcv.2022.105156

Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration

Authors: Synne Arstad Bjørnestad, Noemi Antonella Guadagno, Ingrid Kjos, Cinzia Progida

Journal: iScience

PubMed ID: 35521520

Doi: 10.1016/j.isci.2022.104250

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Partitioning defective 6 homolog alpha (PARD6A) promotes epithelial-mesenchymal transition via integrin β1-ILK-SNAIL1 pathway in ovarian cancer

Authors: Ziwen Lu, Sirui Yuan, Lingling Ruan, Zhigang Tu, Hanqing Liu

Journal: Cell Death Dis

PubMed ID: 35379775

Doi: 10.1038/s41419-022-04756-2

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Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge

Authors: Stian Foss, Alexandra Jonsson, Maria Bottermann, Ruth Watkinson, Heidrun E Lode, Martin B McAdam, Terje E Michaelsen, Inger Sandlie, Leo C James, Jan Terje Andersen

Journal: Sci Immunol

PubMed ID: 35486676

Doi: 10.1126/sciimmunol.abj1640

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Drug-Repurposing Screening Identified Tropifexor as a SARS-CoV-2 Papain-like Protease Inhibitor

Authors: Chunlong Ma, Yanmei Hu, Yuyin Wang, Juliana Choza, Jun Wang

Journal: ACS Infect Dis

PubMed ID: 35404564

Doi: 10.1021/acsinfecdis.1c00629

Products & Services: ORF cDNA Clones/MolecularCloud

Dual Role of HIV-1 Envelope Signal Peptide in Immune Evasion

Authors: Chitra Upadhyay, Priyanka Gadam Rao, Roya Feyznezhad

Journal: Viruses

PubMed ID: 35458538

Doi: 10.3390/v14040808

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Antagonist of Chrna1 prevents the pathogenesis of primary focal hyperhidrosis

Authors: Jian-Bo Lin, Nan-Long Lin, Xu Li, Ming-Qiang Kang

Journal: Ann Clin Transl Neurol

PubMed ID: 35393764

Doi: 10.1002/acn3.51558

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Dynamic immunodominance hierarchy of neutralizing antibody responses to evolving GII4 noroviruses

Authors: Kentaro Tohma, Lauren A Ford-Siltz, Joseph A Kendra, Gabriel I Parra

Journal: Cell Rep

PubMed ID: 35417705

Doi: 10.1016/j.celrep.2022.110689

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Sortase-mediated immobilization of lipase B (CalB) on graphene oxide; comparison with chemical approach

Authors: Faezeh Moosavi, Faezeh Ahrari, Gholamreza Ahmadian, Mehdi Mohammadi

Journal: Biotechnol Rep (Amst)

PubMed ID: 35686009

Doi: 10.1016/j.btre.2022.e00733

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lncRNA STAT4-AS1 Inhibited TH17 Cell Differentiation by Targeting RORt Protein

Authors: Hanlin He, Xiangjie Qiu, Mingming Qi, Ousman Bajinka, Ling Qin, Yurong Tan

Journal: J Immunol Res

PubMed ID: 35528611

Doi: 10.1155/2022/8307280

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Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood

Authors: Tetsuhiro Horie, Kazuya Fukasawa, Takanori Yamada, Seiya Mizuno, Takashi Iezaki, Kazuya Tokumura, Sayuki Iwahashi, Shiho Sakai, Akane Suzuki, Takuya Kubo, Ryoma Osumi, Akane Tomizawa, Hiroki Ochi, Shingo Sato, Katsuyuki Kaneda, Satoru Takahashi, Eiichi Hinoi

Journal: Stem Cells

PubMed ID: 35304894

Doi: 10.1093/stmcls/sxac011

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Dynamic modulation of enzyme activity by synthetic CRISPR-Cas6 endonucleases

Authors: Alexander A Mitkas, Mauricio Valverde, Wilfred Chen

Journal: Nat Chem Biol

PubMed ID: 35468950

Doi: 10.1038/s41589-022-01005-7

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Hydrophobic mismatch is a key factor in protein transport across lipid bilayer membranes via the Tat pathway

Authors: Binhan Hao, Wenjie Zhou, Steven M Theg

Journal: J Biol Chem

PubMed ID: 35490783

Doi: 10.1016/j.jbc.2022.101991

Products & Services: Proteins, Expression, Isolation and Analysis

Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold

Authors: Raphael J Eberle, Ian Gering, Markus Tusche, Philipp N Ostermann, Lisa Müller, Ortwin Adams, Heiner Schaal, Danilo S Olivier, Marcos S Amaral, Raghuvir K Arni, Dieter Willbold, Mônika A Coronado

Journal: Pharmaceuticals (Basel)

PubMed ID: 35631367

Doi: 10.3390/ph15050540

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AdpA, a developmental regulator, promotes ε-poly-l-lysine biosynthesis in Streptomyces albulus

Authors: Rui Huang , Honglu Liu , Wanwan Zhao , Siqi Wang , Shufang Wang , Jun Cai , Chao Yang

Journal: Microb Cell Fact

PubMed ID: 35397580

Doi: 10.1186/s12934-022-01785-6

Products & Services: Gene Synthesis Proteins, Expression, Isolation and Analysis

Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses

Authors: Yingdan Wang, Meiqin Liu, Yaping Shen, Yunping Ma, Xiang Li, Yuanyuan Zhang, Mei Liu, Xing-Lou Yang, Jun Chen, Renhong Yan, Die Luan, Yanqun Wang, Ying Chen, Qimin Wang, Haofeng Lin, Yaning Li, Kaiyue Wu, Tongyu Zhu, Jincun Zhao, Hongzhou Lu, Yumei Wen, Shibo Jiang, Fan Wu, Qiang Zhou, Zheng-Li Shi, Jinghe Huang

Journal: Cell Discov

PubMed ID: 35443747

Doi: 10.1038/s41421-022-00401-6

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A versatile transposon-based technology to generate loss- and gain-of-function phenotypes in the mouse liver

Authors: Anna Georgina Kopasz, Dávid Zsolt Pusztai , Réka Karkas, Liza Hudoba, Khaldoon Sadiq Ahmed Abdullah, Gergely Imre, Gabriella Pankotai-Bodó, Ede Migh, Andrea Nagy, András Kriston, Péter Germán，Andrea Bakné Drubi, Anna Molnár, Ildikó Fekete, Virág Éva Dani, Imre Ocsovszki, László Géza Puskás, Péter Horváth, Farkas Sükösd, Lajos Mátés

Journal: BMC Biol

PubMed ID: 35361222

Doi: 10.1186/s12915-022-01262-x

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Analyzing the Hypothalamus/Pituitary/Interrenal axis of the neopterygian fish, Lepisosteus oculatus: Co-localization of MC2R, MC5R, MRAP1, and MRAP2 in interrenal cells

Authors: Marty Kwok-Shing Wong, Robert M Dores

Journal: Gen Comp Endocrinol

PubMed ID: 35447133

Doi: 10.1016/j.ygcen.2022.114043

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Developing all-in-one virus-like particles for Cas9 mRNA/single guide RNA co-delivery and aptamer-containing lentiviral vectors for improved gene expression

Authors: Manish Yadav , Anthony Atala , Baisong Lu

Journal: Int J Biol Macromol

PubMed ID: 35461863

Doi: 10.1016/j.ijbiomac.2022.04.114

Products & Services: Gene Synthesis

Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes

Authors: Zhirong Fu , Srinivas Akula , Anna-Karin Olsson , Lars Hellman

Journal: Dev Comp Immunol

PubMed ID: 34919980

Doi: 10.1016/j.dci.2021.104337

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Monosaccharide-mediated rational synthesis of a universal plasmonic platform with broad spectral fluorescence enhancement for high-sensitivity cancer biomarker analysis

Authors: Mengyao Liu, Yonghong Li, Wei Xing, Yuqin Zhang, Xi Xie, Jiadong Pang, Fangjian Zhou, Jiang Yang

Journal: J Nanobiotechnology

PubMed ID: 35399094

Doi: 10.1186/s12951-022-01359-z

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Generation of a host cell line containing a MAR-rich landing pad for site-specific integration and expression of transgenes

Authors: Claudia Oliviero, Steffen C Hinz, Jan P Bogen, Henri Kornmann, Björn Hock, Harald Kolmar, Gerrit Hagens

Journal: Biotechnol Prog

PubMed ID: 35396920

Doi: 10.1002/btpr.3254

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PACAP/GCGa Is an Important Modulator of the Amphioxus CNS-Hatschek's Pit Axis, the Homolog of the Vertebrate Hypothalamic-Pituitary Axis in the Basal Chordates

Authors: Jason S W On, Liuru Su, Hong Shen, Aloysius W R Arokiaraj, João C R Cardoso, Guang Li, Billy K C Chow

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35498398

Doi: 10.3389/fendo.2022.850040

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Fish allergens of turbot () parvalbumin triggers food allergy inducing maturation of bone marrow derived dendritic cells and driving Th2 immune response

Authors: Yeting Wu, Youyou Lu, Yuhao Huang, Hong Lin, Mengyao Xu, Ishfaq Ahmed, Guanzhi Chen, Yan Chen, Zhenxing Li

Journal: Food Funct

PubMed ID: 35322825

Doi: 10.1039/d1fo04070g

Products & Services: Proteins, Expression, Isolation and Analysis

Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity

Authors: Jiale Ren, Ni Li, Siyu Pei, Yannan Lian, Li Li, Yuchong Peng, Qiuli Liu, Jiacheng Guo, Xuege Wang, Ying Han, Guoying Zhang, Hanling Wang, Yaqi Li, Jun Jiang, Qintong Li, Minjia Tan, Junjie Peng, Guohong Hu, Yichuan Xiao, Xiong Li, Moubin Lin, Jun Qin

Journal: J Clin Invest

PubMed ID: 35230972

Doi: 10.1172/JCI153167

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Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation

Authors: Fatemeh Adiliaghdam, Hajera Amatullah, Sreehaas Digumarthi, Tahnee L Saunders, Raza-Ur Rahman, Lai Ping Wong, Ruslan Sadreyev, Lindsay Droit, Jean Paquette, Philippe Goyette, John D Rioux, Richard Hodin, Kathie A Mihindukulasuriya, Scott A Handley, Kate L Jeffrey

Journal: Sci Immunol

PubMed ID: 35394816

Doi: 10.1126/sciimmunol.abn6660

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Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH

Authors: Andrea J Parsons, Sabrina I Ophir, J Andrew Duty, Thomas A Kraus, Kathryn R Stein, Thomas M Moran, Domenico Tortorella

Journal: Commun Biol

PubMed ID: 35468974

Doi: 10.1038/s42003-022-03294-z

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Exopolysaccharides from Pantoea alhagi NX-11 specifically improve its root colonization and rice salt resistance

Authors: Liang Sun, Lifangyu Cheng, Yuhang Ma, Peng Lei, Rui Wang, Yian Gu, Sha Li, Fuhai Zhang, Hong Xu

Journal: Int J Biol Macromol

PubMed ID: 35413311

Doi: 10.1016/j.ijbiomac.2022.04.015

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Synthetic carbohydrate-binding agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2

Authors: Oscar Francesconi, Lorena Donnici, Marco Fragai, Elisa Pesce, Mauro Bombaci, Alessandra Fasciani, Lara Manganaro, Matteo Conti, Renata Grifantini, Raffaele De Francesco, Cristina Nativi, Stefano Roelens

Journal: iScience

PubMed ID: 35434540

Doi: 10.1016/j.isci.2022.104239

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ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer

Authors: Eunju Kim, Yoon-Jin Kim, Zhiwei Ji, Jin Muk Kang, Marvin Wirianto, Keshav Raj Paudel, Joshua A Smith, Kaori Ono, Jin-Ah Kim, Kristin Eckel-Mahan, Xiaobo Zhou, Hyun Kyoung Lee, Ji Young Yoo, Seung-Hee Yoo, Zheng Chen

Journal: Cell Death Dis

PubMed ID: 35440077

Doi: 10.1038/s41419-022-04826-5

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Identification of Phosphorylation and Other Post-Translational Modifications in the Central C4C5 Domains of Murine Cardiac Myosin Binding Protein C

Authors: Chang Yoon Doh, Katherine L Dominic, Caitlin E Swanberg, Nikhil Bharambe, Belinda B Willard, Ling Li, Rajesh Ramachandran, Julian E Stelzer

Journal: ACS Omega

PubMed ID: 35573219

Doi: 10.1021/acsomega.2c00799

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Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex

Authors: Kepeng Che, Ajaybabu V Pobbati, Caleb N Seavey, Yuriy Fedorov, Anton A Komar, Ashley Burtscher, Shuang Ma, Brian P Rubin

Journal: PLoS ONE

PubMed ID: 35417479

Doi: 10.1371/journal.pone.0266143

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PINK1/Parkin-mediated mitophagy as a protective mechanism against AFB-induced liver injury in mice

Authors: Qi Wang, Fubo Jia, Chen Guo, Yuping Wang, Xuliang Zhang, Yilong Cui, Miao Song, Zheng Cao, Yanfei Li

Journal: Food Chem Toxicol

PubMed ID: 35447291

Doi: 10.1016/j.fct.2022.113043

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Glycaemic control is associated with SARS-CoV-2 breakthrough infections in vaccinated patients with type 2 diabetes

Authors: Raffaele Marfella, Celestino Sardu, Nunzia D'Onofrio, Francesco Prattichizzo, Lucia Scisciola, Vincenzo Messina, Rosalba La Grotta, Maria Luisa Balestrieri, Paolo Maggi, Claudio Napoli, Antonio Ceriello, Giuseppe Paolisso

Journal: Nat Commun

PubMed ID: 35484164

Doi: 10.1038/s41467-022-30068-2

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Monoclonal antibody targeting the conserved region of the SARS-CoV-2 spike protein to overcome viral variants

Authors: Wan-Ling Wu, Chen-Yi Chiang, Szu-Chia Lai, Chia-Yi Yu, Yu-Ling Huang, Hung-Chun Liao, Ching-Len Liao, Hsin-Wei Chen, Shih-Jen Liu

Journal: JCI Insight

PubMed ID: 35290246

Doi: 10.1172/jci.insight.157597

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Autophagy Underlies the Proteostasis Mechanisms of Artemisinin Resistance in P falciparum Malaria

Authors: Ananya Ray, Miti Mathur, Deepak Choubey, Krishanpal Karmodiya, Namita Surolia

Journal: MBio

PubMed ID: 35420484

Doi: 10.1128/mbio.00630-22

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A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors

Authors: Yanling Wu, Quanxiao Li, Yu Kong, Zhi Wang, Cheng Lei, Ji Li, Lulu Ding, Chunyu Wang, Yaping Cheng, Yaozhu Wei, Yuanlin Song, Zhenlin Yang, Chao Tu, Yu Ding, Tianlei Ying

Journal: Mol Ther

PubMed ID: 35462042

Doi: 10.1016/j.ymthe.2022.04.013

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RNA sensor MDA5 suppresses LINE-1 retrotransposition by regulating the promoter activity of LINE-1 5'-UTR

Authors: Jiaxiu Yan, Yifei Zhao, Juan Du, Yu Wang, Shaohua Wang, Qing Wang, Xu Zhao, Wei Xu, Ke Zhao

Journal: Mob DNA

PubMed ID: 35414110

Doi: 10.1186/s13100-022-00268-0

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Non-homologous End Joining-Mediated Insertional Mutagenesis Reveals a Novel Target for Enhancing Fatty Alcohols Production in

Authors: Mengxu Li, Jinlai Zhang, Qiuyan Bai, Lixia Fang, Hao Song, Yingxiu Cao

Journal: Front Microbiol

PubMed ID: 35547152

Doi: 10.3389/fmicb.2022.898884

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The neural basis of heat seeking in a human-infective parasitic worm

Authors: Astra S Bryant, Felicitas Ruiz, Joon Ha Lee, Elissa A Hallem

Journal: Curr Biol

PubMed ID: 35483361

Doi: 10.1016/j.cub.2022.04.010

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Metabolic engineering of yeasts for green and sustainable production of bioactive ginsenosides F2 and 3,20-Di--Glc-DM

Authors: Fenglin Jiang, Chen Zhou, Yan Li, Haidong Deng, Ting Gong, Jingjing Chen, Tianjiao Chen, Jinling Yang, Ping Zhu

Journal: Acta Pharm Sin B

PubMed ID: 35865098

Doi: 10.1016/j.apsb.2022.04.012

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Repurposing Halicin as a potent covalent inhibitor for the SARS-CoV-2 main protease

Authors: Kai S Yang, Syuan-Ting Alex Kuo, Lauren R Blankenship, Zhi Zachary Geng, Shuhua G Li, David H Russell, Xin Yan, Shiqing Xu, Wenshe Ray Liu

Journal: Curr Res Chem Biol

PubMed ID: 35815070

Doi: 10.1016/j.crchbi.2022.100025

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A small molecule, CHClNOS, inhibits the function of the type III secretion system in Salmonella Typhimurium

Authors: Rerngwit Boonyom, Sittiruk Roytrakul, Patipat Thinwang

Journal: J Genet Eng Biotechnol

PubMed ID: 35380331

Doi: 10.1186/s43141-022-00336-1

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Collagen type IV alpha 1 (COL4A1) silence hampers the invasion, migration and epithelial-mesenchymal transition (EMT) of gastric cancer cells through blocking Hedgehog signaling pathway

Authors: Xijuan Cui, Tao Shan, Lina Qiao

Journal: Bioengineered

PubMed ID: 35297303

Doi: 10.1080/21655979.2022.2053799

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QbD-guided pharmaceutical development of Pembrolizumab biosimilar candidate PSG-024 propelled to industry meeting primary requirements of comparability to Keytruda®

Authors: Morteza Jaffar-Aghaei, Farzad Khanipour, Amir Maghsoudi, Rahim Sarvestani, Mahdi Mohammadian, Maryam Maleki, Forugh Havasi, Hossein Rahmani, Amir-Hossein Karagah, Mohammad-Reza Kazemali

Journal: Eur J Pharm Sci

PubMed ID: 35378209

Doi: 10.1016/j.ejps.2022.106171

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Full-Length Transcriptome Analysis Provides New Insights Into the Diversity of Immune-Related Genes in

Authors: Yi Zhang, Mengqi Ni, Yunhui Bai, Qiao Shi, Jinbin Zheng, Zhaoxia Cui

Journal: Front Immunol

PubMed ID: 35464434

Doi: 10.3389/fimmu.2022.843347

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Regulation of Mannitol Metabolism in Enterococcus faecalis and Association with Toxin-Antitoxin Locus Function

Authors: Srivishnupriya Anbalagan, Jessie Sadlon, Keith Weaver

Journal: J Bacteriol

PubMed ID: 35404112

Doi: 10.1128/jb.00047-22

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The C-terminal extension of VgrG4 from Klebsiella pneumoniae remodels host cell microfilaments

Authors: Talyta do Nascimento Soares, Verônica Silva Valadares, Gisele Cardoso Amorim, Mayara de Mattos Lacerda de Carvalho, Marcia Berrêdo-Pinho, Fábio Ceneviva Lacerda Almeida, Paulo Mascarello Bisch, Paulo Ricardo Batista, Letícia Miranda Santos Lery

Journal: Proteins

PubMed ID: 35430767

Doi: 10.1002/prot.26344

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Hypoxia Drives Centrosome Amplification in Cancer Cells via HIF1α-dependent Induction of Polo-Like Kinase 4

Authors: Karuna Mittal, Jaspreet Kaur, Shaligram Sharma, Nivya Sharma, Guanhao Wei, Ishita Choudhary, Precious Imhansi-Jacob, Nagini Maganti, Shrikant Pawar, Padmashree Rida, Michael S Toss, Mohammed Aleskandarany, Emiel A Janssen, Håvard Søiland, Meenakshi V Gupta, Michelle D Reid, Emad A Rakha, Ritu Aneja

Journal: Mol Cancer Res

PubMed ID: 34933912

Doi: 10.1158/1541-7786.MCR-20-0798

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Distribution of Charged Residues Affects the Average Size and Shape of Intrinsically Disordered Proteins

Authors: Greta Bianchi, Marco Mangiagalli, Alberto Barbiroli, Sonia Longhi, Rita Grandori, Carlo Santambrogio, Stefania Brocca

Journal: Biomolecules

PubMed ID: 35454150

Doi: 10.3390/biom12040561

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as a Model of Unconventional Translation in Spinocerebellar Ataxia Type 3

Authors: Sean L Johnson, Matthew V Prifti, Alyson Sujkowski, Kozeta Libohova, Jessica R Blount, Luke Hong, Wei-Ling Tsou, Sokol V Todi

Journal: Cells

PubMed ID: 35406787

Doi: 10.3390/cells11071223

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Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers

Authors: Chunhong Zheng, Joseph N Fass, Yi-Ping Shih, Andrew J Gunderson, Nelson Sanjuan Silva, Huayu Huang, Brady M Bernard, Venkatesh Rajamanickam, Joseph Slagel, Carlo B Bifulco, Brian Piening, Pippa H A Newell, Paul D Hansen, Eric Tran

Journal: Cancer Cell

PubMed ID: 35413272

Doi: 10.1016/j.ccell.2022.03.005

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DDX17 protects hepatocytes against oleic acid/palmitic acid-induced lipid accumulation

Authors: Xiaoyi Zhang, Tong An, Xiyue Zhang, Tao Shen, Hongxia Li, Lin Dou, Xiuqing Huang, Yong Man, Weiqing Tang, Jian Li

Journal: Biochem Biophys Res Commun

PubMed ID: 35533489

Doi: 10.1016/j.bbrc.2022.04.129

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CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers

Authors: Chuan Jin, Jing Ma, Mohanraj Ramachandran, Di Yu, Magnus Essand

Journal: Nat Biomed Eng

PubMed ID: 35379957

Doi: 10.1038/s41551-022-00875-5

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Neutralization of SARS-CoV-2 Omicron sub-lineages BA1, BA11, and BA2

Authors: John P Evans, Cong Zeng, Panke Qu, Julia Faraone, Yi-Min Zheng, Claire Carlin, Joseph S Bednash, Tongqing Zhou, Gerard Lozanski, Rama Mallampalli, Linda J Saif, Eugene M Oltz, Peter J Mohler, Kai Xu, Richard J Gumina, Shan-Lu Liu

Journal: Cell Host Microbe

PubMed ID: 35526534

Doi: 10.1016/j.chom.2022.04.014

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Efficient CRISPR-Cas9-mediated genome editing for characterization of essential genes in

Authors: Gisele Fernanda Assine Picchi-Constante, Priscila Mazzocchi Hiraiwa, Martin Marek, Vanessa Zulkievicz Rogerio, Eloise Pavão Guerra-Slompo, Christophe Romier, Nilson Ivo Tonin Zanchin

Journal: STAR Protoc

PubMed ID: 35496799

Doi: 10.1016/j.xpro.2022.101324

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Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue

Authors: Lakshmi Prabhu, Matthew Martin, Lan Chen, Özlem Demir, Jiamin Jin, Xiumei Huang, Aishat Motolani, Mengyao Sun, Guanglong Jiang, Harikrishna Nakshatri, Melissa L Fishel, Steven Sun, Ahmad Safa, Rommie E Amaro, Mark R Kelley, Yunlong Liu, Zhong-Yin Zhang, Tao Lu

Journal: Genes Dis

PubMed ID: 37013054

Doi: 10.1016/j.gendis.2022.04.001

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The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development

Authors: Elodie Picarda, Phillip M Galbo, Haihong Zong, Meenu Rohini Rajan, Ville Wallenius, Deyou Zheng, Emma Börgeson, Rajat Singh, Jeffrey Pessin, Xingxing Zang

Journal: Sci Adv

PubMed ID: 35476450

Doi: 10.1126/sciadv.abm7012

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Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5

Authors: Lisa Merklinger, Johannes Bauer, Per A Pedersen, Rune Busk Damgaard, J Preben Morth

Journal: Life Sci Alliance

PubMed ID: 35459736

Doi: 10.26508/lsa.202101309

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FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P-dependent switch

Authors: Nathan R Zaccai, Zuzana Kadlecova, Veronica Kane Dickson, Kseniya Korobchevskaya, Jan Kamenicky, Oleksiy Kovtun, Perunthottathu K Umasankar, Antoni G Wrobel, Jonathan G G Kaufman, Sally R Gray, Kun Qu, Philip R Evans, Marco Fritzsche, Filip Sroubek, Stefan Höning, John A G Briggs, Bernard T Kelly, David J Owen, Linton M Traub

Journal: Sci Adv

PubMed ID: 35486718

Doi: 10.1126/sciadv.abn2018

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Characterization of a universal neutralizing monoclonal antibody against Glaesserella parasuis CdtB

Authors: Qichao Chen, Huan Wang, Liang Li, Shibang Guo, Zhankui Liu, Zizhe Hu, Chen Tan, Huanchun Chen, Xiangru Wang

Journal: Vet Microbiol

PubMed ID: 35640412

Doi: 10.1016/j.vetmic.2022.109446

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LncRNA TSPEAR-AS1 predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma and promotes metastasis via miR-1915-5p

Authors: Yichuan Zhang, Fei Wang, Yu Wang

Journal: Virus Res

PubMed ID: 35477008

Doi: 10.1016/j.virusres.2022.198788

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Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans

Authors: Rasheduzzaman Chowdhury, Martine I Abboud, James Wiley, Anthony Tumber, Suzana Markolovic, Christopher J Schofield

Journal: Sci Rep

PubMed ID: 35410347

Doi: 10.1038/s41598-022-10028-y

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A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation

Authors: Benedetta Mattorre, Silvana Caristi, Simona Donato, Emilia Volpe, Marika Faiella, Alessandro Paiardini, Rosa Sorrentino, Fabiana Paladini

Journal: Int J Mol Sci

PubMed ID: 35563348

Doi: 10.3390/ijms23094961

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Examination of Genetic Control Elements in the Phototrophic Firmicute Heliomicrobium modesticaldum

Authors: Alexandria M Layton , Kevin E Redding

Journal: Microorganisms

PubMed ID: 35630321

Doi: 10.3390/microorganisms10050876

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Characterization of Genetic Variants of Uncertain Significance for the Gene in Patients With Adult Hypophosphatasia

Authors: Raquel Sanabria-de la Torre, Luis Martínez-Heredia, Sheila González-Salvatierra, Francisco Andújar-Vera, Iván Iglesias-Baena, Juan Miguel Villa-Suárez, Victoria Contreras-Bolívar, Mario Corbacho-Soto, Gonzalo Martínez-Navajas, Pedro J Real, Cristina García-Fontana, Manuel Muñoz-Torres, Beatriz García-Fontana

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35498405

Doi: 10.3389/fendo.2022.863940

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Identification of Potential Peptide Marker(s) for Evaluating Pork Meat Freshness via Mass Spectrometry-Based Peptidomics during Storage under Different Temperatures

Authors: Zhenqian Wei, Chen Dai, Anthony P Bassey, Changbo Tang, Yu Han, Chong Wang, Guanghong Zhou

Journal: Foods

PubMed ID: 35454731

Doi: 10.3390/foods11081144

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