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Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current

Authors: Nourdine Chakouri, Sharen Rivas, Daniel Roybal, Lin Yang, Johanna Diaz, Allen Hsu, Ryan Mahling, Bi-Xing Chen, Josiah O Owoyemi, Deborah DiSilvestre, Dario Sirabella, Barbara Corneo, Gordon F Tomaselli, Ivy E Dick, Steven O Marx, Manu Ben-Johny

Journal: Nat Cardiovasc Res

PubMed ID: 35662881

Doi: 10.1038/s44161-022-00060-6

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Gibbin mesodermal regulation patterns epithelial development

Authors: Ann Collier, Angela Liu, Jessica Torkelson, Jillian Pattison, Sadhana Gaddam, Hanson Zhen, Tiffany Patel, Kelly McCarthy, Hana Ghanim, Anthony E Oro

Journal: Nature

PubMed ID: 35585237

Doi: 10.1038/s41586-022-04727-9

Products & Services: Custom DNA/RNA Oligos

Scalable Process for High-Yield Production of CyRPA Using Insect Cells for Inclusion in a Malaria Virosome-Based Vaccine Candidate

Authors: Bárbara Fernandes, Marcos Sousa, Rute Castro, Anja Schäfer, Julia Hauser, Kai Schulze, Mario Amacker, Marco Tamborrini, Gerd Pluschke, Paula M Alves, Sylvain Fleury, António Roldão

Journal: Front Bioeng Biotechnol

PubMed ID: 35669054

Doi: 10.3389/fbioe.2022.879078

Products & Services: Plasmid DNA Preparation

Furin and TMPRSS2 Resistant Spike Induces Robust Humoral and Cellular Immunity Against SARS-CoV-2 Lethal Infection

Authors: Jhe-Jhih Lin, Chih-Feng Tien, Yi-Ping Kuo, En-Ju Lin, Wei-Hsiang Tsai, Ming-Yu Chen, Pei-Ju Tsai, Yu-Wen Su, Nikhil Pathak, Jinn-Moon Yang, Chia-Yi Yu, Zih-Shiuan Chuang, Han-Chieh Wu, Wan-Ting Tsai, Shih-Syong Dai, Hung-Chun Liao, Kit Man Chai, Yu-Siang Su, Tsung-Hsien Chuang, Shih-Jen Liu, Hsin-Wei Chen, Horng-Yunn Dou, Feng-Jui Chen, Chiung-Tong Chen, Chin-Len Liao, Guann-Yi Yu

Journal: Front Immunol

PubMed ID: 35585971

Doi: 10.3389/fimmu.2022.872047

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PI Kinase-EhGEF2-EhRho5 axis contributes to LPA stimulated macropinocytosis in Entamoeba histolytica

Authors: Achala Apte, Maria Manich, Elisabeth Labruyère, Sunando Datta

Journal: PLoS Pathog

PubMed ID: 35594320

Doi: 10.1371/journal.ppat.1010550

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The E3 ubiquitin ligase RNF216/TRIAD3 is a key coordinator of the hypothalamic-pituitary-gonadal axis

Authors: Arlene J George, Bin Dong, Hannah Lail, Morgan Gomez, Yarely C Hoffiz, Christopher B Ware, Ning Fang, Anne Z Murphy, Erik Hrabovszky, Desiree Wanders, Angela M Mabb

Journal: iScience

PubMed ID: 35620441

Doi: 10.1016/j.isci.2022.104386

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Structural Insights on the Conversion of Cytochrome P450 to P420

Authors: Jessica A Gable, Sarvind Tripathi, Thomas L Poulos

Journal: ACS Omega

PubMed ID: 35694512

Doi: 10.1021/acsomega.2c00960

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Naringenin upregulates GTPCH1/eNOS to ameliorate high glucose-induced retinal endothelial cell injury

Authors: Bing Xue, Yu Wang

Journal: Exp Ther Med

PubMed ID: 35607381

Doi: 10.3892/etm.2022.11355

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Gain-of-function pF28S variant in disrupts neuronal differentiation, migration and axonogenesis during cortical development, leading to neurodevelopmental disorder

Authors: Masashi Nishikawa, Marcello Scala, Muhammad Umair, Hidenori Ito, Ahmed Waqas, Pasquale Striano, Federico Zara, Gregory Costain, Valeria Capra, Koh-Ichi Nagata

Journal: J Med Genet

PubMed ID: 35595279

Doi: 10.1136/jmedgenet-2022-108483

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Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway

Authors: Sumin Sun, Sheng Huan, Zhanghao Li, Yue Yao, Ying Su, Siwei Xia, Shijun Wang, Xuefen Xu, Jiangjuan Shao, Zili Zhang, Feng Zhang, Jinbo Fu, Shizhong Zheng

Journal: PeerJ

PubMed ID: 35582617

Doi: 10.7717/peerj.13376

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Immunogenicity and reactogenicity after booster dose with AZD1222 via intradermal route among adult who had received CoronaVac

Authors: Rapisa Nantanee, Puneyavee Aikphaibul, Peera Jaru-Ampornpan, Pimpayao Sodsai, Orawan Himananto, Tuangtip Theerawit, Jiratchaya Sophonphan, Punyot Tovichayathamrong, Kasama Manothummetha, Tysdi Laohasereekul, Narin Hiransuthikul, Nattiya Hirankarn, Thanyawee Puthanakit

Journal: Vaccine

PubMed ID: 35513961

Doi: 10.1016/j.vaccine.2022.04.067

Products & Services: Mammalian Expression

6-Valent Virus-Like Particle-Based Vaccine Induced Potent and Sustained Immunity Against Noroviruses in Mice

Authors: Wenli Hou, Lihui Lv, Yihan Wang, Man Xing, Yingying Guo, Di Xie, Xin Wei, Xiuyue Zhang, Hui Liu, Jiling Ren, Dongming Zhou

Journal: Front Immunol

PubMed ID: 35711416

Doi: 10.3389/fimmu.2022.906275

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Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia

Authors: Zhi Ruan, Kayo Takamatsu-Yukawa, Yuzhi Wang, Margaret L Ushman, Adam Thomas Labadorf, Maria Ericsson, Seiko Ikezu, Tsuneya Ikezu

Journal: Cell Rep

PubMed ID: 35545052

Doi: 10.1016/j.celrep.2022.110791

Products & Services: Mammalian Expression

Immune recall improves antibody durability and breadth to SARS-CoV-2 variants

Authors: Yuezhou Chen, Pei Tong, Noah Whiteman, Ali Sanjari Moghaddam, Mehrdad Zarghami, Adam Zuiani, Shaghayegh Habibi, Avneesh Gautam, F Keerti, Caihong Bi, Tianshu Xiao, Yongfei Cai, Bing Chen, Donna Neuberg, Duane R Wesemann

Journal: Sci Immunol

PubMed ID: 35549298

Doi: 10.1126/sciimmunol.abp8328

Products & Services: Proteins, Expression, Isolation and Analysis

Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: a serological analysis

Authors: Frauke Muecksch, Helen Wise, Kate Templeton, Becky Batchelor, Maria Squires, Kirsty McCance, Lisa Jarvis, Kristen Malloy, Elizabeth Furrie, Claire Richardson, Jacqueline MacGuire, Ian Godber, Alana Burns, Sally Mavin, Fengwen Zhang, Fabian Schmidt, Paul D Bieniasz, Sara Jenks, Theodora Hatziioannou

Journal: Lancet Microbe

PubMed ID: 35636436

Doi: 10.1016/S2666-5247(22)00090-8

The dopamine transporter antiports potassium to increase the uptake of dopamine

Authors: Solveig G Schmidt, Mette Galsgaard Malle, Anne Kathrine Nielsen, Søren S-R Bohr, Ciara F Pugh, Jeppe C Nielsen, Ida H Poulsen, Kasper D Rand, Nikos S Hatzakis, Claus J Loland

Journal: Nat Commun

PubMed ID: 35508541

Doi: 10.1038/s41467-022-30154-5

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Exploring Calbindin-IMPase fusion proteins structure and activity

Authors: James W Noble, John R Atack

Journal: Biochem Biophys Rep

PubMed ID: 35540435

Doi: 10.1016/j.bbrep.2022.101266

Products & Services: Proteins, Expression, Isolation and Analysis

Knockout Alleviates DSS-Induced Colitis Regulating the Immune Function of Dendritic Cells

Authors: Wei Wei, Sucheng Mu, Yi Han, Yao Chen, Zhongshu Kuang, Xingyue Wu, Yue Luo, Chaoyang Tong, Yiqun Zhang, Yilin Yang, Zhenju Song

Journal: Front Immunol

PubMed ID: 35669778

Doi: 10.3389/fimmu.2022.841254

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Extracellular fructooligosaccharide degradation in Anaerostipes hadrus for co-metabolism with non-fructooligosaccharide utilizers

Authors: Akihito Endo, Hiroki Tanno, Ren Kadowaki, Tadashi Fujii, Takumi Tochio

Journal: Biochem Biophys Res Commun

PubMed ID: 35537289

Doi: 10.1016/j.bbrc.2022.04.134

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Electron transfer activity of the nanodisc-bound mitochondrial outer membrane protein mitoNEET

Authors: Homyra Tasnim, Huangen Ding

Journal: Free Radic Biol Med

PubMed ID: 35609862

Doi: 10.1016/j.freeradbiomed.2022.05.011

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Role of Glutaminase 2 in Promoting CD4+ T Cell Production of Interleukin-2 by Supporting Antioxidant Defense in Systemic Lupus Erythematosus

Authors: Ryo Hisada, Nobuya Yoshida, Seo Yeon K Orite, Masataka Umeda, Catalina Burbano, Marc Scherlinger, Michihito Kono, Suzanne Krishfield, George C Tsokos

Journal: Arthritis Rheumatol

PubMed ID: 35254008

Doi: 10.1002/art.42112

Products & Services: Mammalian Expression

Development of an LNP-Encapsulated mRNA-RBD Vaccine against SARS-CoV-2 and Its Variants

Authors: Cong Liu, Nino Rcheulishvili, Zhigao Shen, Dimitri Papukashvili, Fengfei Xie, Ziqian Wang, Xingyun Wang, Yunjiao He, Peng George Wang

Journal: Pharmaceutics

PubMed ID: 35631687

Doi: 10.3390/pharmaceutics14051101

Products & Services: Proteins, Expression, Isolation and Analysis

The Inclusion Membrane Protein CTL0390 Mediates Host Cell Exit via Lysis through STING Activation

Authors: R Clayton Bishop, Isabelle Derré

Journal: Infect Immun

PubMed ID: 35587198

Doi: 10.1128/iai.00190-22

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The B-box1 domain of PML mediates SUMO E2-E3 complex formation through an atypical interaction with UBC9

Authors: Thomas Bregnard, Affrin Ahmed, Irina V Semenova, Sandra K Weller, Irina Bezsonova

Journal: Biophys Chem

PubMed ID: 35667129

Doi: 10.1016/j.bpc.2022.106827

Products & Services: Proteins, Expression, Isolation and Analysis

Specific N-glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning

Authors: Maisha Rahman, Nelson J Ramirez-Suarez, Carlos A Diaz-Balzac, Hannes E Bülow

Journal: EMBO Rep

PubMed ID: 35586945

Doi: 10.15252/embr.202154163

Products & Services: Proteins, Expression, Isolation and Analysis

Influence of Cortisol on the Fibril Formation Kinetics of Aβ42 Peptide: A Multi-Technical Approach

Authors: Alessandro Nucara, Francesca Ripanti, Simona Sennato, Giacomo Nisini, Emiliano De Santis, Mahta Sefat, Marina Carbonaro, Dalila Mango, Velia Minicozzi, Marilena Carbone

Journal: Int J Mol Sci

PubMed ID: 35682687

Doi: 10.3390/ijms23116007

Products & Services: Proteins, Expression, Isolation and Analysis

Optical Fluorescence Imaging of Native Proteins Using a Fluorescent Probe with a Cell-Membrane-Permeable Carboxyl Group

Authors: Jung Min Kim, Young-Mi Kang

Journal: Int J Mol Sci

PubMed ID: 35628651

Doi: 10.3390/ijms23105841

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Electrochemical biosensor for rapid detection of fungal contamination in fuel systems

Authors: Osman Radwan, Michael C Brothers, Victoria Coyle, Molly E Chapleau, Richard R Chapleau, Steve S Kim, Oscar N Ruiz

Journal: Biosens Bioelectron

PubMed ID: 35605548

Doi: 10.1016/j.bios.2022.114374

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Rationally engineering santalene synthase to readjust the component ratio of sandalwood oil

Authors: Wenlong Zha, Fan Zhang, Jiaqi Shao, Xingmei Ma, Jianxun Zhu, Pinghua Sun, Ruibo Wu, Jiachen Zi

Journal: Nat Commun

PubMed ID: 35523896

Doi: 10.1038/s41467-022-30294-8

Products & Services: Proteins, Expression, Isolation and Analysis

Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex

Authors: Heidi Gytz Olesen, Iliana Michailidou, Wioleta M Zelek, Jeroen Vreijling, Patrick Ruizendaal, Ferry de Klein, J Arnoud Marquart, Thomas B Kuipers, Hailiang Mei, Yuchun Zhang, Muhammad Ahasan, Krista K Johnson, Yi Wang, B Paul Morgan, Marcus van Dijk, Kees Fluiter, Gregers Rom Andersen, Frank Baas

Journal: J Innate Immun

PubMed ID: 35551129

Doi: 10.1159/000524587

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An Ex Vivo 3D Tumor Microenvironment-Mimicry Culture to Study TAM Modulation of Cancer Immunotherapy

Authors: Yan-Ruide Li, Yanqi Yu, Adam Kramer, Ryan Hon, Matthew Wilson, James Brown, Lili Yang

Journal: Cells

PubMed ID: 35563889

Doi: 10.3390/cells11091583

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Authors: Kevin Yau, Christopher T Chan, Kento T Abe, Yidi Jiang, Mohammad Atiquzzaman, Sarah I Mullin, Ellen Shadowitz, Lisa Liu, Ema Kostadinovic, Tatjana Sukovic, Anny Gonzalez, Margaret E McGrath-Chong, Matthew J Oliver, Jeffrey Perl, Jerome A Leis, Shelly Bolotin, Vanessa Tran, Adeera Levin, Peter G Blake, Karen Colwill, Anne-Claude Gingras, Michelle A Hladunewich

Journal: CMAJ

PubMed ID: 35636760

Doi: 10.1503/cmaj.211881-f

Products & Services: Monoclonal Antibody Services

Brassica napus genes Rlm4 and Rlm7, conferring resistance to Leptosphaeria maculans, are alleles of the Rlm9 wall-associated kinase-like resistance locus

Authors: Parham Haddadi, Nicholas J Larkan, Angela Van deWouw, Yueqi Zhang, Ting Xiang Neik, Elena Beynon, Philipp Bayer, Dave Edwards, Jacqueline Batley, Mohammad Hossein Borhan

Journal: Plant Biotechnol J

PubMed ID: 35338565

Doi: 10.1111/pbi.13818

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LncRNA OIP5-AS1 modulates the proliferation and apoptosis of Jurkat cells by sponging miR-181c-5p to regulate IL-7 expression in myasthenia gravis

Authors: Xu Wang, Huixue Zhang, Xiaoyu Lu, Shuang Li, Xiaotong Kong, Li Liu, Lifang Li, Si Xu, Tianfeng Wang, Jianjian Wang, Lihua Wang

Journal: PeerJ

PubMed ID: 35602889

Doi: 10.7717/peerj.13454

Products & Services: Gene Synthesis

Binding Properties of RNA Quadruplex of SARS-CoV-2 to Berberine Compared to Telomeric DNA Quadruplex

Authors: Rosario Oliva, Sanjib Mukherjee, Magiliny Manisegaran, Marco Campanile, Pompea Del Vecchio, Luigi Petraccone, Roland Winter

Journal: Int J Mol Sci

PubMed ID: 35628500

Doi: 10.3390/ijms23105690

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Homologous or heterogenous vaccination boosters enhance neutralizing activities against SARS-CoV-2 Omicron BA1 variant

Authors: Zhongcheng Zhou, Peng Du, Ning Li, Xinxin Xiong, Shengjun Tang, Qinjin Dai, Taorui Wang, Meixing Yu, Miao Man, Kelvin Lam, Daniel T Baptista-Hon, Wa Hou Tai, Olivia Monteiro, Weng Sam Ng, Un Man Lee, Zhihai Liu, Kang Zhang, Gen Li

Journal: MedComm (2020)

PubMed ID: 35592756

Doi: 10.1002/mco2.143

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Identification of Epitopes on Rhinovirus 89 Capsid Proteins Capable of Inducing Neutralizing Antibodies

Authors: Katarzyna Niespodziana, Clarissa R Cabauatan, Petra Pazderova, Phyllis C Vacal, Judith Wortmann, Walter Keller, Peter Errhalt, Rudolf Valenta

Journal: Int J Mol Sci

PubMed ID: 35563505

Doi: 10.3390/ijms23095113

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A Facile Method to Produce N-Terminally Truncated α-Synuclein

Authors: Rebecca J Thrush, Devkee M Vadukul, Francesco A Aprile

Journal: Front Neurosci

PubMed ID: 35692420

Doi: 10.3389/fnins.2022.881480

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Cryo-EM structures of the human surfactant lipid transporter ABCA3

Authors: Tian Xie, Zike Zhang, Jian Yue, Qi Fang, Xin Gong

Journal: Sci Adv

PubMed ID: 35394827

Doi: doi/10.1126/sciadv.abn3727

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LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs

Authors: Marina N Iriondo , Asier Etxaniz , Yaiza R Varela , Uxue Ballesteros , Javier H Hervás , L Ruth Montes , Félix M Goñi , Alicia Alonso

Journal: Autophagy

PubMed ID: 35414338

Doi: 10.1080/15548627.2022.2062111

Products & Services: PCR Cloning and Subcloning

Amyloid fishing: β-Amyloid adsorption using tailor-made coated titania nanoparticles

Authors: Elad Arad , Raz Jelinek , Hanna Rapaport

Journal: Colloids Surf B Biointerfaces

PubMed ID: 35121429

Doi: 10.1016/j.colsurfb.2022.112374

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Targeting intrinsically disordered regions facilitates discovery of CaV3.2 inhibitory peptides for AAV-mediated peripheral analgesia

Authors: Seung Min Shin , Justas Lauzadis , Brandon Itson-Zoske , Yongsong Cai 1 , Fan Fan , Gayathri Natarajan , Wai-Meng Kwok , Michelino Puopolo , Quinn H Hogan , Hongwei Yu

Journal: Pain

PubMed ID: 35420557

Doi: 10.1097/j.pain.0000000000002650

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Specific knockdown of by CRISPR-CasRx prevents acquired sensorineural hearing loss in mice

Authors: Yang Guo, Lei Han, Shuang Han, Honghai Tang, Shengyi Wang, Chong Cui, Bing Chen, Huawei Li, Yilai Shu

Journal: Mol Ther Nucleic Acids

PubMed ID: 35615000

Doi: 10.1016/j.omtn.2022.04.014

Products & Services: Proteins, Expression, Isolation and Analysis

Immmunoinformatics-based design of a multi-epitope vaccine with CTLA-4 extracellular domain to combat Helicobacter pylori

Authors: Zhenyu Ru, Mingkai Yu, Yuejie Zhu, Zhiqiang Chen, Fengbo Zhang, Zhiqiang Zhang, Jianbing Ding

Journal: FASEB J

PubMed ID: 35294065

Doi: 10.1096/fj.202101538RR

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p53 alters intracellular Ca signaling through regulation of TRPM4

Authors: Sven Kappel, Daniela Ross-Kaschitza, Barbara Hauert, Karen Rother, Christine Peinelt

Journal: Cell Calcium

PubMed ID: 35500522

Doi: 10.1016/j.ceca.2022.102591

Products & Services: Proteins, Expression, Isolation and Analysis

a New IFN-Inducible Human Member of the Ly6a Subfamily Expressed by Spleen Cells and Associated with Inflammation and Viral Resistance

Authors: Moriya Shmerling, Michael Chalik, Nechama I Smorodinsky, Alan Meeker, Sujayita Roy, Orit Sagi-Assif, Tsipi Meshel, Artem Danilevsky, Noam Shomron, Shmuel Levinger, Bar Nishry, David Baruchi, Avital Shargorodsky, Ravit Ziv, Avital Sarusi-Portuguez, Maoz Lahav, Marcelo Ehrlich, Bryony Braschi, Elspeth Bruford, Isaac P Witz, Daniel H Wreschner

Journal: Immunohorizons

PubMed ID: 35440514

Doi: 10.4049/immunohorizons.2200018

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A Bacterially Expressed SARS-CoV-2 Receptor Binding Domain Fused With Cross-Reacting Material 197 A-Domain Elicits High Level of Neutralizing Antibodies in Mice

Authors: Liqin Liu, Tingting Chen, Lizhi Zhou, Jie Sun, Yuqian Li, Meifeng Nie, Hualong Xiong, Yuhe Zhu, Wenhui Xue, Yangtao Wu, Tingting Li, Tianying Zhang, Zhibo Kong, Hai Yu, Jun Zhang, Ying Gu, Qingbing Zheng, Qinjian Zhao, Ningshao Xia, Shaowei Li

Journal: Front Microbiol

PubMed ID: 35558112

Doi: 10.3389/fmicb.2022.854630

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Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but moderately reduced lung inflammation

Authors: Koen K A Van Rompay, Katherine J Olstad, Rebecca L Sammak, Joseph Dutra, Jennifer K Watanabe, Jodie L Usachenko, Ramya Immareddy, Jamin W Roh, Anil Verma, Yashavanth Shaan Lakshmanappa, Brian A Schmidt, Clara Di Germanio, Nabeela Rizvi, Hongwei Liu, Zhong-Min Ma, Mars Stone, Graham Simmons, Larry J Dumont, A Mark Allen, Sarah Lockwood, Rachel E Pollard, Rafael Ramiro de Assis, JoAnn L Yee, Peter B Nham, Amir Ardeshir, Jesse D Deere, Aarti Jain, Philip L Felgner, Lark L Coffey, Smita S Iyer, Dennis J Hartigan-O'Connor, Michael P Busch, J Rachel Reader

Journal: PLoS Pathog

PubMed ID: 35443018

Doi: 10.1371/journal.ppat.1009925

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Formulation of simvastatin within high density lipoprotein enables potent tumour radiosensitisation

Authors: Pouya Dehghankelishadi, Michelle F Maritz, Nicole Dmochowska, Parisa Badiee, Edward Cheah, Ivan Kempson, Ross I Berbeco, Benjamin Thierry

Journal: J Control Release

PubMed ID: 35447296

Doi: 10.1016/j.jconrel.2022.04.017

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Cathepsin B-Cleavable Polymeric Photosensitizer Prodrug for Selective Photodynamic Therapy: In Vitro Studies

Authors: Manish Jain, Jordan Bouilloux, Ines Borrego, Stéphane Cook, Hubert van den Bergh, Norbert Lange, Georges Wagnieres, Marie-Noelle Giraud

Journal: Pharmaceuticals (Basel)

PubMed ID: 35631388

Doi: 10.3390/ph15050564

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Tuning the Sensitivity of Genetically Encoded Fluorescent Potassium Indicators through Structure-Guided and Genome Mining Strategies

Authors: Cristina C Torres Cabán, Minghan Yang, Cuixin Lai, Lina Yang, Fedor V Subach, Brian O Smith, Kiryl D Piatkevich, Edward S Boyden

Journal: ACS Sens

PubMed ID: 35427452

Doi: 10.1021/acssensors.1c02201

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Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway

Authors: Xiaofang Wei, Juan Tan, Hui Gao

Journal: Bioengineered

PubMed ID: 35383535

Doi: 10.1080/21655979.2022.2060626

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Thermodynamically coupled biosensors for detecting neutralizing antibodies against SARS-CoV-2 variants

Authors: Jason Z Zhang, Hsien-Wei Yeh, Alexandra C Walls, Basile I M Wicky, Kaitlin R Sprouse, Laura A VanBlargan, Rebecca Treger, Alfredo Quijano-Rubio, Minh N Pham, John C Kraft, Ian C Haydon, Wei Yang, Michelle DeWitt, John E Bowen, Cameron M Chow, Lauren Carter, Rashmi Ravichandran, Mark H Wener, Lance Stewart, David Veesler, Michael S Diamond, Alexander L Greninger, David M Koelle, David Baker

Journal: Nat Biotechnol

PubMed ID: 35484405

Doi: 10.1038/s41587-022-01280-8

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A third dose of mRNA-1273 vaccine improves SARS-CoV-2 immunity in HCT recipients with low antibody response after 2 doses

Authors: Elena Pettini, Annalisa Ciabattini, Gabiria Pastore, Jacopo Polvere, Simone Lucchesi, Fabio Fiorino, Francesca Montagnani, Alessandro Bucalossi, Monica Tozzi, Giuseppe Marotta, Donata Medaglini

Journal: Blood Adv

PubMed ID: 35073574

Doi: 10.1182/bloodadvances.2021006599

The recombinant defensin/HSA fusion protein that inhibits NF-κb associated with intensive macropinocytosis shows potent efficacy against pancreatic cancer

Authors: Yi-Bo Du, Xiao-Fei Wang, Xiu-Jun Liu, Yi Li, Qing-Fang Miao, Min Jiang, Wei-Jin Sheng, Yong-Su Zhen

Journal: Biochem Pharmacol

PubMed ID: 35489393

Doi: 10.1016/j.bcp.2022.115057

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Functional differentiation of three pheromone binding proteins in Orthaga achatina using mixed-type sex pheromones

Authors: Yu-Xiao Si, Jin-Meng Guo, Hui Liao, Yu Li, Yu Ma, Yu-Wei Zhu, Zhi-Qiang Wei, Shuang-Lin Dong, Qi Yan

Journal: Pestic Biochem Physiol

PubMed ID: 35715036

Doi: 10.1016/j.pestbp.2022.105097

Products & Services: Proteins, Expression, Isolation and Analysis

Hypomethylation-mediated upregulation of the WASF2 promoter region correlates with poor clinical outcomes in hepatocellular carcinoma

Authors: Hye Ri Ahn, Geum Ok Baek, Moon Gyeong Yoon, Ju A Son, Jung Hwan Yoon, Jae Youn Cheong, Hyo Jung Cho, Ho Chul Kang, Jung Woo Eun, Soon Sun Kim

Journal: J Exp Clin Cancer Res

PubMed ID: 35477411

Doi: 10.1186/s13046-022-02365-7

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A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis

Authors: Lei Zhang, James E Kent, Meredith Whitaker, David C Young, Dominik Herrmann, Alexander E Aleshin, Ying-Hui Ko, Gino Cingolani, Jamil S Saad, D Branch Moody, Francesca M Marassi, Sabine Ehrt, Michael Niederweis

Journal: Nat Commun

PubMed ID: 35474308

Doi: 10.1038/s41467-022-29873-6

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L-tyrosine-bound ThiH structure reveals C-C bond break differences within radical SAM aromatic amino acid lyases

Authors: Patricia Amara, Claire Saragaglia, Jean-Marie Mouesca, Lydie Martin, Yvain Nicolet

Journal: Nat Commun

PubMed ID: 35477710

Doi: 10.1038/s41467-022-29980-4

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C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Carbapenemase OXA-23 by Impeding Deacylation

Authors: Nichole K Stewart, Marta Toth, Maha A Alqurafi, Weirui Chai, Thu Q Nguyen, Pojun Quan, Mijoon Lee, John D Buynak, Clyde A Smith, Sergei B Vakulenko

Journal: MBio

PubMed ID: 35420470

Doi: 10.1128/mbio.00367-22

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Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B11529

Authors: Tongqing Zhou, Lingshu Wang, John Misasi, Amarendra Pegu, Yi Zhang, Darcy R Harris, Adam S Olia, Chloe Adrienna Talana, Eun Sung Yang, Man Chen, Misook Choe, Wei Shi, I-Ting Teng, Adrian Creanga, Claudia Jenkins, Kwanyee Leung, Tracy Liu, Erik-Stephane D Stancofski, Tyler Stephens, Baoshan Zhang, Yaroslav Tsybovsky, Barney S Graham, John R Mascola, Nancy J Sullivan, Peter D Kwong

Journal: Science

PubMed ID: 35324257

Doi: 10.1126/science.abn8897

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Neutralization of Myotoxin II, a Phospholipase A Homologue from Venom, Using Peptides Discovered via Phage Display Technology

Authors: Andreas H Laustsen, Bengt H Gless, Timothy P Jenkins, Maria Meyhoff-Madsen, Johanna Bjärtun, Andreas S Munk, Saioa Oscoz, Julián Fernández, José María Gutiérrez, Bruno Lomonte, Brian Lohse

Journal: ACS Omega

PubMed ID: 35571794

Doi: 10.1021/acsomega.2c00280

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Targeting kinesin family member 21B by miR-132-3p represses cell proliferation, migration and invasion in gastric cancer

Authors: Bingtian Liu, Ling Qiang, Bingxin Guan, Zhipeng Ji

Journal: Bioengineered

PubMed ID: 35341446

Doi: 10.1080/21655979.2022.2054755

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Mitochondrial micropeptide STMP1 promotes G1/S transition by enhancing mitochondrial complex IV activity

Authors: Ye Sang, Jin-Yu Liu, Feng-Yi Wang, Xiao-Yu Luo, Zi-Qi Chen, Shi-Mei Zhuang, Ying Zhu

Journal: Mol Ther

PubMed ID: 35450818

Doi: 10.1016/j.ymthe.2022.04.012

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Hapten-labeled fusion-polymerase chain reaction of multiple marker genes for the application of immunochromatographic test

Authors: Atsushi Tabata, Rina Shirai, Haruka Miki, Yukihiro Nishikawa, Tatsuya Kashima, Tomomi Aoyama, Shu Murakami, Momoyo Azuma, Toshifumi Tomoyasu, Hideaki Nagamune

Journal: J Biosci Bioeng

PubMed ID: 35450786

Doi: 10.1016/j.jbiosc.2022.03.006

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Identifying Small-Molecule Inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase by Establishing a Fluorometric Assay

Authors: Xiaoming Bai, Hongmin Sun, Shuo Wu, Yuhuan Li, Lifei Wang, Bin Hong

Journal: Front Immunol

PubMed ID: 35464436

Doi: 10.3389/fimmu.2022.844749

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Conserved metabolic enzymes as vaccine antigens for giardiasis

Authors: Sozaburo Ihara, Yukiko Miyamoto, Christine H Y Le, Vivien N Tran, Elaine M Hanson, Marvin Fischer, Kurt Hanevik, Lars Eckmann

Journal: PLoS Negl Trop Dis

PubMed ID: 35468132

Doi: 10.1371/journal.pntd.0010323

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Armet from whitefly saliva acts as an effector to suppress plant defences by targeting tobacco cystatin

Authors: Hui Du, Hong-Xing Xu, Fang Wang, Li-Xin Qian, Shu-Sheng Liu, Xiao-Wei Wang

Journal: New Phytol

PubMed ID: 35238409

Doi: 10.1111/nph.18063

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Biomimetic biphasic curdlan-based scaffold for osteochondral tissue engineering applications - Characterization and preliminary evaluation of mesenchymal stem cell response in vitro

Authors: Katarzyna Klimek, Aleksandra Benko, Marta Vandrovcova, Martina Travnickova, Timothy E L Douglas, Marta Tarczynska, Antonin Broz, Krzysztof Gaweda, Grazyna Ginalska, Lucie Bacakova

Journal: Biomater Adv

PubMed ID: 35929204

Doi: 10.1016/j.bioadv.2022.212724

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SARS-CoV-2 nsp5 Exhibits Stronger Catalytic Activity and Interferon Antagonism than Its SARS-CoV Ortholog

Authors: Jiyao Chen, Zhuang Li, Jiahui Guo, Shangen Xu, Junwei Zhou, Qian Chen, Xue Tong, Dang Wang, Guiqing Peng, Liurong Fang, Shaobo Xiao

Journal: J Virol

PubMed ID: 35389264

Doi: 10.1128/jvi.00037-22

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Structural characterization of a dimerization interface in the CD28 transmembrane domain

Authors: Hongyi Wu, Ruiyu Cao, Maorong Wen, Hongjuan Xue, Bo OuYang

Journal: Structure

PubMed ID: 35397202

Doi: 10.1016/j.str.2022.03.004

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Multiple Polypyrimidine Tract Elements Regulate a Cooperative Mechanism for Triticum Mosaic Virus Internal Ribosomal Entry Site Activity

Authors: Helena Jaramillo-Mesa, Emma Fischer, Aurélie M Rakotondrafara

Journal: Front Plant Sci

PubMed ID: 35498652

Doi: 10.3389/fpls.2022.864832

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Evaluation of biotransformation capacity of transplastomic plants and hairy roots of Nicotiana tabacum expressing human cytochrome P450 2D6

Authors: Y V Sheludko, I M Gerasymenko, F J Herrmann, H Warzecha

Journal: Transgenic Res

PubMed ID: 35416604

Doi: 10.1007/s11248-022-00305-x

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Production of interferon gamma and interleukin 17A in chicken T-cell subpopulations hallmarks the stimulation with live, irradiated and killed avian pathogenic Escherichia coli

Authors: Sina Bagheri, Surya Paudel, Viskam Wijewardana, Richard Thiga Kangethe, Giovanni Cattoli, Michael Hess, Dieter Liebhart, Taniya Mitra

Journal: Dev Comp Immunol

PubMed ID: 35390358

Doi: 10.1016/j.dci.2022.104408

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A Recombinant Turkey Herpesvirus Expressing the F Protein of Newcastle Disease Virus Genotype XII Generated by NHEJ-CRISPR/Cas9 and Cre-LoxP Systems Confers Protection against Genotype XII Challenge in Chickens

Authors: Katherine Calderón, Aldo Rojas-Neyra, Brigith Carbajal-Lévano, Luis Luján-Valenzuela, Julio Ticona, Gisela Isasi-Rivas, Angela Montalvan, Manuel Criollo-Orozco, Edison Huaccachi-Gonzáles, Luis Tataje-Lavanda, Karla Lucia F Alvarez, Manolo Fernández-Sánchez, Manolo Fernández-Díaz, Na Tang, Yongxiu Yao, Venugopal Nair

Journal: Viruses

PubMed ID: 35458523

Doi: 10.3390/v14040793

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Circ_0047921 acts as the sponge of miR-1287-5p to stimulate lung cancer progression by regulating proliferation, migration, invasion, and glycolysis of lung cancer cells

Authors: Yuehua Xiao, Shequn Gu, Wenxiu Yao, Ling Qin, Jihui Luo

Journal: World J Surg Oncol

PubMed ID: 35365169

Doi: 10.1186/s12957-021-02466-1

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Monoclonal antibody 7H22 binds the C-terminus of the cancer-oocyte antigen SAS1B through the hydrophilic face of a conserved amphipathic helix corresponding to one of only two regions predicted to be ordered

Authors: Max S G Legg, Susannah M L Gagnon, Cameron J Powell, Martin J Boulanger, Andra J J Li, Stephen V Evans

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35503210

Doi: 10.1107/S2059798322003011

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High-yield overproduction and purification of human aquaporins from

Authors: Tamim Al-Jubair, Jonas Hyld Steffen, Julie Winkel Missel, Philip Kitchen, Mootaz M Salman, Roslyn M Bill, Pontus Gourdon, Susanna Törnroth-Horsefield

Journal: STAR Protoc

PubMed ID: 35463467

Doi: 10.1016/j.xpro.2022.101298

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Immunogenicity and safety of homologous and heterologous ChAdOx1-S and mRNA-1273 vaccinations in healthy adults in Taiwan

Authors: Chun-Min Kang, Nan-Yao Lee, Chih-Hsueh Lin, Yuan-Shan Hsu, Yu-Chang Chang, Ming-Yi Chung, Ya-Fan Lee, Wen-Pin Tseng, Jhong-Lin Wu, Shey-Ying Chen, Min-Chi Lu, Wen-Chien Ko, Ping-Ing Lee, Po-Ren Hsueh

Journal: J Clin Virol

PubMed ID: 35413588

Doi: 10.1016/j.jcv.2022.105156

Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration

Authors: Synne Arstad Bjørnestad, Noemi Antonella Guadagno, Ingrid Kjos, Cinzia Progida

Journal: iScience

PubMed ID: 35521520

Doi: 10.1016/j.isci.2022.104250

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Partitioning defective 6 homolog alpha (PARD6A) promotes epithelial-mesenchymal transition via integrin β1-ILK-SNAIL1 pathway in ovarian cancer

Authors: Ziwen Lu, Sirui Yuan, Lingling Ruan, Zhigang Tu, Hanqing Liu

Journal: Cell Death Dis

PubMed ID: 35379775

Doi: 10.1038/s41419-022-04756-2

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Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge

Authors: Stian Foss, Alexandra Jonsson, Maria Bottermann, Ruth Watkinson, Heidrun E Lode, Martin B McAdam, Terje E Michaelsen, Inger Sandlie, Leo C James, Jan Terje Andersen

Journal: Sci Immunol

PubMed ID: 35486676

Doi: 10.1126/sciimmunol.abj1640

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Drug-Repurposing Screening Identified Tropifexor as a SARS-CoV-2 Papain-like Protease Inhibitor

Authors: Chunlong Ma, Yanmei Hu, Yuyin Wang, Juliana Choza, Jun Wang

Journal: ACS Infect Dis

PubMed ID: 35404564

Doi: 10.1021/acsinfecdis.1c00629

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Dual Role of HIV-1 Envelope Signal Peptide in Immune Evasion

Authors: Chitra Upadhyay, Priyanka Gadam Rao, Roya Feyznezhad

Journal: Viruses

PubMed ID: 35458538

Doi: 10.3390/v14040808

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Antagonist of Chrna1 prevents the pathogenesis of primary focal hyperhidrosis

Authors: Jian-Bo Lin, Nan-Long Lin, Xu Li, Ming-Qiang Kang

Journal: Ann Clin Transl Neurol

PubMed ID: 35393764

Doi: 10.1002/acn3.51558

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Dynamic immunodominance hierarchy of neutralizing antibody responses to evolving GII4 noroviruses

Authors: Kentaro Tohma, Lauren A Ford-Siltz, Joseph A Kendra, Gabriel I Parra

Journal: Cell Rep

PubMed ID: 35417705

Doi: 10.1016/j.celrep.2022.110689

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Sortase-mediated immobilization of lipase B (CalB) on graphene oxide; comparison with chemical approach

Authors: Faezeh Moosavi, Faezeh Ahrari, Gholamreza Ahmadian, Mehdi Mohammadi

Journal: Biotechnol Rep (Amst)

PubMed ID: 35686009

Doi: 10.1016/j.btre.2022.e00733

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lncRNA STAT4-AS1 Inhibited TH17 Cell Differentiation by Targeting RORt Protein

Authors: Hanlin He, Xiangjie Qiu, Mingming Qi, Ousman Bajinka, Ling Qin, Yurong Tan

Journal: J Immunol Res

PubMed ID: 35528611

Doi: 10.1155/2022/8307280

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Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood

Authors: Tetsuhiro Horie, Kazuya Fukasawa, Takanori Yamada, Seiya Mizuno, Takashi Iezaki, Kazuya Tokumura, Sayuki Iwahashi, Shiho Sakai, Akane Suzuki, Takuya Kubo, Ryoma Osumi, Akane Tomizawa, Hiroki Ochi, Shingo Sato, Katsuyuki Kaneda, Satoru Takahashi, Eiichi Hinoi

Journal: Stem Cells

PubMed ID: 35304894

Doi: 10.1093/stmcls/sxac011

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Dynamic modulation of enzyme activity by synthetic CRISPR-Cas6 endonucleases

Authors: Alexander A Mitkas, Mauricio Valverde, Wilfred Chen

Journal: Nat Chem Biol

PubMed ID: 35468950

Doi: 10.1038/s41589-022-01005-7

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Hydrophobic mismatch is a key factor in protein transport across lipid bilayer membranes via the Tat pathway

Authors: Binhan Hao, Wenjie Zhou, Steven M Theg

Journal: J Biol Chem

PubMed ID: 35490783

Doi: 10.1016/j.jbc.2022.101991

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Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold

Authors: Raphael J Eberle, Ian Gering, Markus Tusche, Philipp N Ostermann, Lisa Müller, Ortwin Adams, Heiner Schaal, Danilo S Olivier, Marcos S Amaral, Raghuvir K Arni, Dieter Willbold, Mônika A Coronado

Journal: Pharmaceuticals (Basel)

PubMed ID: 35631367

Doi: 10.3390/ph15050540

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AdpA, a developmental regulator, promotes ε-poly-l-lysine biosynthesis in Streptomyces albulus

Authors: Rui Huang , Honglu Liu , Wanwan Zhao , Siqi Wang , Shufang Wang , Jun Cai , Chao Yang

Journal: Microb Cell Fact

PubMed ID: 35397580

Doi: 10.1186/s12934-022-01785-6

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Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses

Authors: Yingdan Wang, Meiqin Liu, Yaping Shen, Yunping Ma, Xiang Li, Yuanyuan Zhang, Mei Liu, Xing-Lou Yang, Jun Chen, Renhong Yan, Die Luan, Yanqun Wang, Ying Chen, Qimin Wang, Haofeng Lin, Yaning Li, Kaiyue Wu, Tongyu Zhu, Jincun Zhao, Hongzhou Lu, Yumei Wen, Shibo Jiang, Fan Wu, Qiang Zhou, Zheng-Li Shi, Jinghe Huang

Journal: Cell Discov

PubMed ID: 35443747

Doi: 10.1038/s41421-022-00401-6

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A versatile transposon-based technology to generate loss- and gain-of-function phenotypes in the mouse liver

Authors: Anna Georgina Kopasz, Dávid Zsolt Pusztai , Réka Karkas, Liza Hudoba, Khaldoon Sadiq Ahmed Abdullah, Gergely Imre, Gabriella Pankotai-Bodó, Ede Migh, Andrea Nagy, András Kriston, Péter Germán，Andrea Bakné Drubi, Anna Molnár, Ildikó Fekete, Virág Éva Dani, Imre Ocsovszki, László Géza Puskás, Péter Horváth, Farkas Sükösd, Lajos Mátés

Journal: BMC Biol

PubMed ID: 35361222

Doi: 10.1186/s12915-022-01262-x

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Analyzing the Hypothalamus/Pituitary/Interrenal axis of the neopterygian fish, Lepisosteus oculatus: Co-localization of MC2R, MC5R, MRAP1, and MRAP2 in interrenal cells

Authors: Marty Kwok-Shing Wong, Robert M Dores

Journal: Gen Comp Endocrinol

PubMed ID: 35447133

Doi: 10.1016/j.ygcen.2022.114043

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Developing all-in-one virus-like particles for Cas9 mRNA/single guide RNA co-delivery and aptamer-containing lentiviral vectors for improved gene expression

Authors: Manish Yadav , Anthony Atala , Baisong Lu

Journal: Int J Biol Macromol

PubMed ID: 35461863

Doi: 10.1016/j.ijbiomac.2022.04.114

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Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes

Authors: Zhirong Fu , Srinivas Akula , Anna-Karin Olsson , Lars Hellman

Journal: Dev Comp Immunol

PubMed ID: 34919980

Doi: 10.1016/j.dci.2021.104337

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Examination of Genetic Control Elements in the Phototrophic Firmicute Heliomicrobium modesticaldum

Authors: Alexandria M Layton , Kevin E Redding

Journal: Microorganisms

PubMed ID: 35630321

Doi: 10.3390/microorganisms10050876

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Monosaccharide-mediated rational synthesis of a universal plasmonic platform with broad spectral fluorescence enhancement for high-sensitivity cancer biomarker analysis

Authors: Mengyao Liu, Yonghong Li, Wei Xing, Yuqin Zhang, Xi Xie, Jiadong Pang, Fangjian Zhou, Jiang Yang

Journal: J Nanobiotechnology

PubMed ID: 35399094

Doi: 10.1186/s12951-022-01359-z

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