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Disordered Regions Flanking the Binding Interface Modulate Affinity between CBP and NCOA

Authors: Elin Karlsson, Jan Schnatwinkel, Cristina Paissoni, Eva Andersson, Christian Herrmann, Carlo Camilloni, Per Jemth

Journal: J Mol Biol

PubMed ID: 35605677

Doi: 10.1016/j.jmb.2022.167643

Products & Services: Plasmid DNA Preparation

A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases

Authors: Inna Rozman Grinberg, Markel Martínez-Carranza, Ornella Bimai, Ghada Nouaïria, Saher Shahid, Daniel Lundin, Derek T Logan, Britt-Marie Sjöberg, Pål Stenmark

Journal: Nat Commun

PubMed ID: 35577776

Doi: 10.1038/s41467-022-30328-1

Products & Services: Custom DNA/RNA Oligos

Trajectory patterns of SARS-CoV-2 neutralising antibody response in convalescent COVID-19 patients

Authors: Ngai Sze Wong, Shui Shan Lee, Denise P C Chan, Timothy C M Li, Tracy H Y Ho, Fion W L Luk, Kai Ming Chow, Eugene Y K Tso, Eng-Kiong Yeoh, Samuel Y S Wong, David S C Hui, Grace C Y Lui

Journal: Commun Med (Lond)

PubMed ID: 35603297

Doi: 10.1038/s43856-022-00119-2

Products & Services: Proteins, Expression, Isolation and Analysis

The BCC7 Protein Contributes to the Basal Pole by Interfacing between the MyoC Motor and the IMC Membrane Network

Authors: Luis Vigetti, Tatiana Labouré, Chloé Roumégous, Dominique Cannella, Bastien Touquet, Claudine Mayer, Yohann Couté, Karine Frénal, Isabelle Tardieux, Patricia Renesto

Journal: Int J Mol Sci

PubMed ID: 35682673

Doi: 10.3390/ijms23115995

Products & Services: Proteins, Expression, Isolation and Analysis

Structural Stability and Antigenicity of Universal Equine H3N8 Hemagglutinin Trimer upon Release from Polyanhydride Nanoparticles and Pentablock Copolymer Hydrogels

Authors: Alaric C Siddoway, David Verhoeven, Kathleen A Ross, Michael J Wannemuehler, Surya K Mallapragada, Balaji Narasimhan

Journal: ACS Biomater Sci Eng

PubMed ID: 35604784

Doi: 10.1021/acsbiomaterials.2c00219

Products & Services: Proteins, Expression, Isolation and Analysis

Jinlida Granules Reduce Obesity in db/db Mice by Activating Beige Adipocytes

Authors: Hong-Ru Zhou, Tong-Xing Wang, Yuan-Yuan Hao, Yun-Long Hou, Cong Wei, Bing Yao, Xuan Wu, Dan Huang, Hui Zhang, Yi-Ling Wu

Journal: Biomed Res Int

PubMed ID: 35647185

Doi: 10.1155/2022/4483009

Products & Services: Proteins, Expression, Isolation and Analysis

An intrinsically disordered protein region encoded by the human disease gene regulates mitophagy

Authors: Morgan A Gingerich, Xueying Liu, Biaoxin Chai, Gemma L Pearson, Michael P Vincent, Tracy Stromer, Jie Zhu, Vaibhav Sidarala, Aaron Renberg, Debashish Sahu, Daniel J Klionsky, Santiago Schnell, Scott A Soleimanpour

Journal: Autophagy

PubMed ID: 35604110

Doi: 10.1080/15548627.2022.2080383

Products & Services: Proteins, Expression, Isolation and Analysis

The cytochrome P450s of Leptographium qinlingensis: Gene characteristics, phylogeny, and expression in response to terpenoids

Authors: Lulu Dai, Jingyun Xie, Yirui Liu, Hui Chen, Jie Zheng

Journal: Fungal Biol

PubMed ID: 35667827

Doi: 10.1016/j.funbio.2022.05.003

Products & Services: DNA Sequencing

Activity of AZD7442 (tixagevimab-cilgavimab) against Omicron SARS-CoV-2 in patients with hematologic malignancies

Authors: Robert Stuver, Gunjan L Shah, Neha S Korde, Lindsey E Roeker, Anthony R Mato, Connie L Batlevi, David J Chung, Sital Doddi, Lorenzo Falchi, Boglarka Gyurkocza, Audrey Hamilton, Ya-Hui Lin, Ann A Jakubowski, Erel Joffe, Heather L Landau, Richard J Lin, Sham Mailankody, M Lia Palomba, Jae H Park, Miguel-Angel Perales, Doris M Ponce, Lakshmi V Ramanathan, Gilles A Salles, Michael Scordo, Susan K Seo, Urvi A Shah, Eytan M Stein, David Straus, Saad Z Usmani, James W Young, Andrew D Zelenetz, Ariela Noy, Santosha A Vardhana

Journal: Cancer Cell

PubMed ID: 35598602

Doi: 10.1016/j.ccell.2022.05.007

Products & Services: Recombinant Proteins

A Novel Human Neutralizing mAb Recognizes Delta, Gamma and Omicron Variants of SARS-CoV-2 and Can Be Used in Combination with Sotrovimab

Authors: Margherita Passariello, Veronica Ferrucci, Emanuele Sasso, Lorenzo Manna, Rosa Rapuano Lembo, Stefano Pascarella, Giovanna Fusco, Nicola Zambrano, Massimo Zollo, Claudia De Lorenzo

Journal: Int J Mol Sci

PubMed ID: 35628365

Doi: 10.3390/ijms23105556

Products & Services: Mammalian Expression

Neutralizing antibody and T cell responses against SARS-CoV-2 variants of concern following ChAdOx-1 or BNT162b2 boosting in the elderly previously immunized with CoronaVac vaccine

Authors: Chalerm Liwsrisakun, Supansa Pata, Witida Laopajon, Nuchjira Takheaw, Warawut Chaiwong, Juthamas Inchai, Chaicharn Pothirat, Chaiwat Bumroongkit, Athavudh Deesomchok, Theerakorn Theerakittikul, Atikun Limsukon, Pattraporn Tajarernmuang, Nutchanok Niyatiwatchanchai, Konlawij Trongtrakul, Kantinan Chuensirikulchai, Watchara Kasinrerk

Journal: Immun Ageing

PubMed ID: 35610643

Doi: 10.1186/s12979-022-00279-8

Products & Services: Proteins, Expression, Isolation and Analysis

Evaluating blood-brain barrier disruption and infarction volume concurrently in rats subjected to ischemic stroke using an optical imaging system

Authors: Yao He, Yingqian Zhang, Wanxin Li, Qinxi Li, Bangcheng Zhao, Xun Tang, Daojun Chen, Ting Zhang, Tao Zhang, Zhihui Zhong

Journal: J Neurosci Methods

PubMed ID: 35613659

Doi: 10.1016/j.jneumeth.2022.109630

Products & Services: Proteins, Expression, Isolation and Analysis

Functionalization of a symmetric protein scaffold: Redundant folding nuclei and alternative oligomeric folding pathways

Authors: Connie A Tenorio, Joseph B Parker, Michael Blaber

Journal: Protein Sci

PubMed ID: 35481645

Doi: 10.1002/pro.4301

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The highly conserved stem-loop II motif is important for the lifecycle of astroviruses but dispensable for SARS-CoV-2

Authors: Andrew B Janowski, Hongbing Jiang, Chika Fujii, Macee C Owen, Traci L Bricker, Tamarand L Darling, Houda H Harastani, Kuljeet Seehra, Stephen Tahan, Ana Jung, Binita Febles, Joshua A Blatter, Scott A Handley, Bijal A Parikh, Valeria Lulla, Adrianus Cm Boon, David Wang

Journal: biorxiv

PubMed ID: 35547847

Doi: 10.1101/2022.04.30.486882

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Maternal Exercise Before and During Pregnancy Facilitates Embryonic Myogenesis by Enhancing Thyroid Hormone Signaling

Authors: Yao Gao, Liang Zhao, Jun Seok Son, Xiangdong Liu, Yanting Chen, Jeanene Marie Deavila, Mei-Jun Zhu, Gordon K Murdoch, Min Du

Journal: Thyroid

PubMed ID: 35286177

Doi: 10.1089/thy.2021.0639

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Circular RNA testis-expressed 14 overexpression induces apoptosis and suppresses migration of ox-LDL-stimulated vascular smooth muscle cells via regulating the microRNA 6509-3p/thanatos-associated domain-containing apoptosis-associated protein 1 axis

Authors: Lu Kou, Ning Yang, Bo Dong, Jingyu Yang, Yanqiu Song, Yang Li, Qin Qin

Journal: Bioengineered

PubMed ID: 35635088

Doi: 10.1080/21655979.2022.2070582

Products & Services: Plasmid DNA Preparation

Application of CRISPR/CasΦ2 System for Genome Editing in Plants

Authors: Qinan Cai, Dongmei Guo, Yujun Cao, Yuan Li, Rui Ma, Wenping Liu

Journal: Int J Mol Sci

PubMed ID: 35628563

Doi: 10.3390/ijms23105755

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Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis

Authors: Andy Weiss, Caitlin C Murdoch, Katherine A Edmonds, Matthew R Jordan, Andrew J Monteith, Yasiru R Perera, Aslin M Rodríguez Nassif, Amber M Petoletti, William N Beavers, Matthew J Munneke, Sydney L Drury, Evan S Krystofiak, Kishore Thalluri, Hongwei Wu, Angela R S Kruse, Richard D DiMarchi, Richard M Caprioli, Jeffrey M Spraggins, Walter J Chazin, David P Giedroc, Eric P Skaar

Journal: Cell

PubMed ID: 35584702

Doi: 10.1016/j.cell.2022.04.011

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Lipolysis-Stimulated Lipoprotein Receptor Impairs Hepatocellular Carcinoma and Inhibits the Oncogenic Activity of YAP1 PPPY Motif

Authors: Xin Dong, Xianbin Zhang, Peng Liu, Yu Tian, Li Li, Peng Gong

Journal: Front Oncol

PubMed ID: 35586495

Doi: 10.3389/fonc.2022.896412

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Validated determination of NRG1 Ig-like domain structure by mass spectrometry coupled with computational modeling

Authors: Niloofar Abolhasani Khaje, Alexander Eletsky, Sarah E Biehn, Charles K Mobley, Monique J Rogals, Yoonkyoo Kim, Sushil K Mishra, Robert J Doerksen, Steffen Lindert, James H Prestegard, Joshua S Sharp

Journal: Commun Biol

PubMed ID: 35551273

Doi: 10.1038/s42003-022-03411-y

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Specific bio-functional CBD-PR1P peptide binding VEGF to collagen hydrogels promotes the recovery of cerebral ischemia in rats

Authors: Jia Yin, Chunying Shi, Wenli He, Wenjing Yan, Jin Deng, Bing Zhang, Mengmeng Yin, Haitao Pei, Haiping Wang

Journal: J Biomed Mater Res A

PubMed ID: 35603700

Doi: 10.1002/jbm.a.37409

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis for the synthesis of the core 1 structure by C1GalT1

Authors: Andrés Manuel González-Ramírez, Ana Sofia Grosso, Zhang Yang, Ismael Compañón, Helena Coelho, Yoshiki Narimatsu, Henrik Clausen, Filipa Marcelo, Francisco Corzana, Ramon Hurtado-Guerrero

Journal: Nat Commun

PubMed ID: 35504880

Doi: 10.1038/s41467-022-29833-0

Products & Services: Codon Optimization

FastCAT Accelerates Absolute Quantification of Proteins Using Multiple Short Nonpurified Chimeric Standards

Authors: Ignacy Rzagalinski, Aliona Bogdanova, Bharath Kumar Raghuraman, Eric R Geertsma, Lena Hersemann, Tjalf Ziemssen, Andrej Shevchenko

Journal: J Proteome Res

PubMed ID: 35561006

Doi: 10.1021/acs.jproteome.2c00014

Products & Services: Molecular Biology Tools

Safety and immunogenicity of an egg-based inactivated Newcastle disease virus vaccine expressing SARS-CoV-2 spike: Interim results of a randomized, placebo-controlled, phase 1/2 trial in Vietnam

Authors: Anh Duc Dang, Thiem Dinh Vu, Ha Hai Vu, Van Thanh Ta, Anh Thi Van Pham, Mai Thi Ngoc Dang, Be Van Le, Thai Huu Duong, Duoc Van Nguyen, Saranath Lawpoolsri, Pailinrut Chinwangso, Jason S McLellan, Ching-Lin Hsieh, Adolfo Garcia-Sastre, Peter Palese, Weina Sun, Jose L Martinez, Irene Gonzalez-Dominguez, Stefan Slamanig, Juan Manuel Carreño, Johnstone Tcheou, Florian Krammer, Ariel Raskin, Huong Minh Vu, Thang Cong Tran, Huong Mai Nguyen, Laina D Mercer, Rama Raghunandan, Manjari Lal, Jessica A White, Richard Hjorth, Bruce L Innis, Rami Scharf

Journal: Vaccine

PubMed ID: 35577631

Doi: 10.1016/j.vaccine.2022.04.078

Products & Services: Mammalian Expression

Class III Peroxidases PRX01, PRX44, and PRX73 Control Root Hair Growth in

Authors: Eliana Marzol, Cecilia Borassi, Mariana Carignani Sardoy, Philippe Ranocha, Ariel A Aptekmann, Mauro Bringas, Janice Pennington, Julio Paez-Valencia, Javier Martínez Pacheco, Diana R Rodríguez-Garcia, Yossmayer Del Carmen Rondón Guerrero, Juan Manuel Peralta, Margaret Fleming, John W Mishler-Elmore, Silvina Mangano, Francisca Blanco-Herrera, Patricia A Bedinger, Christophe Dunand, Luciana Capece, Alejandro D Nadra, Michael Held, Marisa S Otegui, José M Estevez

Journal: Int J Mol Sci

PubMed ID: 35628189

Doi: 10.3390/ijms23105375

Products & Services: Plasmid DNA Preparation

Correction: The arginine deaminase system plays distinct roles in Borrelia burgdorferi and Borrelia hermsii

Authors: Crystal L Richards, Sandra J Raffel, Sébastien Bontemps-Gallo, Daniel P Dulebohn, Tessa C Herbert, Frank C Gherardini

Journal: PLoS Pathog

PubMed ID: 35536845

Doi: 10.1371/journal.ppat.1010549

Products & Services: Proteins, Expression, Isolation and Analysis

Low specific growth rate and temperature in fed-batch cultures of a beta-propeller phytase producing Pichia pastoris strain under GAP promoter trigger increased KAR2 and PSA1-1 gene expression yielding enhanced extracellular productivity

Authors: Ana Lucía Herrera-Estala, José Antonio Fuentes-Garibay, Martha Guerrero-Olazarán, José María Viader-Salvadó

Journal: J Biotechnol

PubMed ID: 35618082

Doi: 10.1016/j.jbiotec.2022.05.010

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Enzymatically amplified linear dbDNA as a rapid and scalable solution to industrial lentiviral vector manufacturing

Authors: Maria Barreira, Claire Kerridge, Sara Jorda, Didrik Olofsson, Alexander Neumann, Helen Horton, Sarah Smith-Moore

Journal: Gene Ther

PubMed ID: 35606492

Doi: 10.1038/s41434-022-00343-4

Products & Services: Gene Synthesis

Adverse effects following anti-COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes

Authors: Ayesa Syenina, Esther S Gan, Justin Z N Toh, Ruklanthi de Alwis, Lowell Z Lin, Christine Y L Tham, Jia Xin Yee, Yan Shan Leong, Huizhen Sam, Charlene Cheong, Yii Ean Teh, Ian L E Wee, Dorothy H L Ng, Kuan Rong Chan, Jean X Y Sim, Shirin Kalimuddin, Eugenia Z Ong, Jenny G Low, Eng Eong Ooi

Journal: PLoS Biol

PubMed ID: 35639676

Doi: 10.1371/journal.pbio.3001643

SEC is an antiangiogenic virulence factor that promotes endocarditis independent of superantigen activity

Authors: Kyle J Kinney, Sharon S Tang, Xiao-Jun Wu, Phuong M Tran, Nikhila S Bharadwaj, Katherine N Gibson-Corley, Ana N Forsythe, Katarina Kulhankova, Jenny E Gumperz, Wilmara Salgado-Pabón

Journal: Sci Adv

PubMed ID: 35544579

Doi: 10.1126/sciadv.abo1072

Products & Services: Gene Synthesis

High-throughput drug screening allowed identification of entry inhibitors specifically targeting different routes of SARS-CoV-2 Delta and Omicron/BA1

Authors: Maria Kuzikov, Jannis Woens, Andrea Zaliani, Julia Hambach, Thomas Eden, Boris Fehse, Bernhard Ellinger, Kristoffer Riecken

Journal: Biomed Pharmacother

PubMed ID: 35643072

Doi: 10.1016/j.biopha.2022.113104

Products & Services: Plasmid DNA Preparation

Scalable biological signal recording in mammalian cells using Cas12a base editors

Authors: Hannah R Kempton, Kasey S Love, Lucie Y Guo, Lei S Qi

Journal: Nat Chem Biol

PubMed ID: 35637351

Doi: 10.1038/s41589-022-01034-2

Products & Services: Proteins, Expression, Isolation and Analysis

Two Liberibacter Proteins Combine to Suppress Critical Innate Immune Defenses in Citrus

Authors: Supratim Basu, Loan Huynh, Shujian Zhang, Roel Rabara, Hau Nguyen, Jeanette Velásquez Guzmán, Guixia Hao, Godfrey Miles, Qingchun Shi, Ed Stover, Goutam Gupta

Journal: Front Plant Sci

PubMed ID: 35586217

Doi: 10.3389/fpls.2022.869178

Products & Services: PCR Cloning and Subcloning

Characterization and clustering of kinase isoform expression in metastatic melanoma

Authors: David O Holland, Valer Gotea, Kevin Fedkenheuer, Sushil K Jaiswal, Catherine Baugher, Hua Tan, Michael Fedkenheuer, Laura Elnitski

Journal: PLoS Comput Biol

PubMed ID: 35560144

Doi: 10.1371/journal.pcbi.1010065

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Convergent Alterations of a Protein Hub Produce Divergent Effects within a Binding Site

Authors: Ali Imran, Brandon S Moyer, Dan Kalina, Thomas M Duncan, Kelsey J Moody, Aaron J Wolfe, Michael S Cosgrove, Liviu Movileanu

Journal: ACS Chem Biol

PubMed ID: 35613319

Doi: 10.1021/acschembio.2c00273

Products & Services: Proteins, Expression, Isolation and Analysis

The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer

Authors: Almutasem Saleh, Yasunori Noguchi, Ricardo Aramayo, Marina E Ivanova, Kathryn M Stevens, Alex Montoya, S Sunidhi, Nicolas Lopez Carranza, Marcin J Skwark, Christian Speck

Journal: Nat Commun

PubMed ID: 35614055

Doi: 10.1038/s41467-022-30576-1

Products & Services: Mutant Libraries

Correlation Analysis of Anti-SARS-CoV-2 RBD IgG and Neutralizing Antibody against SARS-CoV-2 Omicron Variants after Vaccination

Authors: Nuchjira Takheaw, Chalerm Liwsrisakun, Warawut Chaiwong, Witida Laopajon, Supansa Pata, Juthamas Inchai, Pilaiporn Duangjit, Chaicharn Pothirat, Chaiwat Bumroongkit, Athavudh Deesomchok, Theerakorn Theerakittikul, Atikun Limsukon, Pattraporn Tajarernmuang, Nutchanok Niyatiwatchanchai, Konlawij Trongtrakul, Watchara Kasinrerk

Journal: Diagnostics (Basel)

PubMed ID: 35741126

Doi: 10.3390/diagnostics12061315

Klotho-derived peptide 6 ameliorates diabetic kidney disease by targeting Wnt/b-catenin signaling

Authors: Xiaowen Chen , Huishi Tan , Jie Xu , Yuan Tian , Qian Yuan , Yangyang Zuo , Qiyan Chen , Xue Hong , Haiyan Fu , Fan Fan Hou , Lili Zhou , Youhua Liu

Journal: Kidney Int

PubMed ID: 35644285

Doi: 10.1016/j.kint.2022.04.028

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New Beta-lactamases in Candidate Phyla Radiation: Owning Pleiotropic Enzymes Is a Smart Paradigm for Microorganisms with a Reduced Genome

Authors: Mohamad Maatouk , Ahmad Ibrahim , Lucile Pinault , Nicholas Armstrong , Said Azza , Jean-Marc Rolain , Fadi Bittar , Didier Raoult

Journal: Int J Mol Sci

PubMed ID: 35628255

Doi: 10.3390/ijms23105446

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A plant immune protein enables broad antitumor response by rescuing microRNA deficiency

Authors: Ye Qi , Li Ding , Siwen Zhang , Shengze Yao , Jennie Ong , Yi Li , Hong Wu , Peng Du

Journal: Cell

PubMed ID: 35623329

Doi: 10.1016/j.cell.2022.04.030

Products & Services: Proteins, Expression, Isolation and Analysis

A time-resolved fluorescence lateral flow immunochromatographic assay based on oriented immobilized antibodies for the ultrasensitive detection of C-peptides in human serum

Authors: Binger Yu, Yong Cui, Xinyi Mao, Zijing Li, Zepeng Li, Guoqing Shi

Journal: Anal Chim Acta

PubMed ID: 35525590

Doi: 10.1016/j.aca.2022.339833

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A bivalent vaccine containing D614G and BA.1 spike trimer proteins or a BA.1 spike trimer protein booster shows broad neutralizing immunity

Authors: Peng Du, Ning Li, Xinxin Xiong, Shengjun Tang, Qinjin Dai, Zhihai Liu, Taorui Wang, Xueping Gu, Zhongcheng Zhou

Journal: J Med Virol

PubMed ID: 35614524

Doi: 10.1002/jmv.27885

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Biliverdin regulates NR2E3 and zebrafish retinal photoreceptor development.

Authors: Blaine Connor, Kayla Titialii-Torres, Abigail E Rockenhaus, Samuel Passamonte, Ann C Morris, Young-Sam Lee

Journal: Sci Rep

PubMed ID: 35508617

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Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration

Authors: Zhicheng Cao , Hongmei Wang , Jialin Chen , Yanan Zhang , Qingyun Mo , Po Zhang, Mingyue Wang , Haoyang Liu , Xueyang Bao , Yuzhi Sun , Wei Zhang , Qingqiang Yao

Journal: Bioact Mater

PubMed ID: 35702612

Doi: 10.1016/j.bioactmat.2022.05.025

Products & Services: Proteins, Expression, Isolation and Analysis

Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants

Authors: Yin-Feng Kang , Cong Sun , Jing Sun , Chu Xie , Zhen Zhuang , Hui-Qin Xu , Zheng Liu , Yi-Hao Liu , Sui Peng , Run-Yu Yuan , Jin-Cun Zhao , Mu-Sheng Zeng

Journal: Nat Commun

PubMed ID: 35562337

Doi: 10.1038/s41467-022-30222-w

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Novel Function of CtXyn5A from Acetivibrio thermocellus: Dual Arabinoxylanase and Feruloyl Esterase Activity Occur in the Same Active Site

Authors: Eva Schmitz, Savvina Leontakianakou, Patrick Adlercreutz, Eva Nordberg Karlsson, Javier A. Linares-Pastén

Journal: Research Portal at Lubd University

Doi: 10.26434/chemrxiv-2022-dt3bb

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Author Correction: Deletion and tandem duplications of biosynthetic genes drive the diversity of triterpenoids in Aralia elata

Authors: Yu Wang, He Zhang, Hyok Chol Ri, Zeyu An, Xin Wang, Jia-Nan Zhou, Dongran Zheng, Hao Wu, Pengchao Wang, Jianfei Yang, Ding-Kun Liu, Diyang Zhang, Wen-Chieh Tsai, Zheyong Xue, Zhichao Xu, Peng Zhang, Zhong-Jian Liu, Hailong Shen, Yuhua Li

Journal: Nat Commun

PubMed ID: 35523784

Doi: 10.1038/s41467-022-30370-z

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Strong off-target antibody reactivity to malarial antigens induced by RTS,S/AS01E vaccination is associated with protection

Authors: Dídac Macià, Joseph J Campo, Gemma Moncunill, Chenjerai Jairoce, Augusto J Nhabomba, Maximilian Mpina, Hermann Sorgho, David Dosoo, Ousmane Traore, Kwadwo Asamoah Kusi, Nana Aba Williams, Amit Oberai, Arlo Randall, Hèctor Sanz, Clarissa Valim, Kwaku Poku Asante, Seth Owusu-Agyei, Halidou Tinto, Selidji Todagbe Agnandji, Simon Kariuki, Ben Gyan, Claudia Daubenberger, Benjamin Mordmüller, Paula Petrone, Carlota Dobaño

Journal: JCI Insight

PubMed ID: 35446785

Doi: 10.1172/jci.insight.158030

Products & Services: Bacterial Expression

Characterization of Immunological Responses to Immunogenic Protein A (BipA), a Species-Specific Antigen for North American Tick-Borne Relapsing Fever

Authors: Michael W Curtis, Aparna Krishnavajhala, Alexander R Kneubehl, Monica E Embers, Jenna R Gettings, Michael J Yabsley, Job E Lopez

Journal: Microbiol Spectr

PubMed ID: 35579456

Doi: 10.1128/spectrum.01722-21

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Characterization and Identification of a New Daidzein Reductase Involved in ()-Equol Biosynthesis in sp ZJ6

Authors: Yunfei Hu, Chunfang Yang, Can Song, Weixuan Zhong, Baiyuan Li, Linyan Cao, Huahai Chen, Changhui Zhao, Yeshi Yin

Journal: Front Microbiol

PubMed ID: 35668767

Doi: 10.3389/fmicb.2022.901745

Products & Services: Bacterial Expression

Clade-Specific Alterations within the HIV-1 Capsid Protein with Implications for Nuclear Translocation

Authors: Alexej Dick, Megan E Meuser, Simon Cocklin

Journal: Biomolecules

PubMed ID: 35625621

Doi: 10.3390/biom12050695

Products & Services: Recombinant Antibody Expression

Efficient suppression of endogenous CFTR nonsense mutations using anticodon-engineered transfer RNAs

Authors: Wooree Ko, Joseph J Porter, Matthew T Sipple, Katherine M Edwards, John D Lueck

Journal: Mol Ther Nucleic Acids

PubMed ID: 35664697

Doi: 10.1016/j.omtn.2022.04.033

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Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development

Authors: Delfina M Romero, Karine Poirier, Richard Belvindrah, Imane Moutkine, Anne Houllier, Anne-Gaëlle LeMoing, Florence Petit, Anne Boland, Stephan C Collins, Mariano Soiza-Reilly, Binnaz Yalcin, Jamel Chelly, Jean-François Deleuze, Nadia Bahi-Buisson, Fiona Francis

Journal: Nat Commun

PubMed ID: 35585091

Doi: 10.1038/s41467-022-30443-z

Products & Services: Mammalian Expression

Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current

Authors: Nourdine Chakouri, Sharen Rivas, Daniel Roybal, Lin Yang, Johanna Diaz, Allen Hsu, Ryan Mahling, Bi-Xing Chen, Josiah O Owoyemi, Deborah DiSilvestre, Dario Sirabella, Barbara Corneo, Gordon F Tomaselli, Ivy E Dick, Steven O Marx, Manu Ben-Johny

Journal: Nat Cardiovasc Res

PubMed ID: 35662881

Doi: 10.1038/s44161-022-00060-6

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Scalable Process for High-Yield Production of CyRPA Using Insect Cells for Inclusion in a Malaria Virosome-Based Vaccine Candidate

Authors: Bárbara Fernandes, Marcos Sousa, Rute Castro, Anja Schäfer, Julia Hauser, Kai Schulze, Mario Amacker, Marco Tamborrini, Gerd Pluschke, Paula M Alves, Sylvain Fleury, António Roldão

Journal: Front Bioeng Biotechnol

PubMed ID: 35669054

Doi: 10.3389/fbioe.2022.879078

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Furin and TMPRSS2 Resistant Spike Induces Robust Humoral and Cellular Immunity Against SARS-CoV-2 Lethal Infection

Authors: Jhe-Jhih Lin, Chih-Feng Tien, Yi-Ping Kuo, En-Ju Lin, Wei-Hsiang Tsai, Ming-Yu Chen, Pei-Ju Tsai, Yu-Wen Su, Nikhil Pathak, Jinn-Moon Yang, Chia-Yi Yu, Zih-Shiuan Chuang, Han-Chieh Wu, Wan-Ting Tsai, Shih-Syong Dai, Hung-Chun Liao, Kit Man Chai, Yu-Siang Su, Tsung-Hsien Chuang, Shih-Jen Liu, Hsin-Wei Chen, Horng-Yunn Dou, Feng-Jui Chen, Chiung-Tong Chen, Chin-Len Liao, Guann-Yi Yu

Journal: Front Immunol

PubMed ID: 35585971

Doi: 10.3389/fimmu.2022.872047

Products & Services: Codon Optimization

Structural Insights on the Conversion of Cytochrome P450 to P420

Authors: Jessica A Gable, Sarvind Tripathi, Thomas L Poulos

Journal: ACS Omega

PubMed ID: 35694512

Doi: 10.1021/acsomega.2c00960

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Gain-of-function pF28S variant in disrupts neuronal differentiation, migration and axonogenesis during cortical development, leading to neurodevelopmental disorder

Authors: Masashi Nishikawa, Marcello Scala, Muhammad Umair, Hidenori Ito, Ahmed Waqas, Pasquale Striano, Federico Zara, Gregory Costain, Valeria Capra, Koh-Ichi Nagata

Journal: J Med Genet

PubMed ID: 35595279

Doi: 10.1136/jmedgenet-2022-108483

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Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway

Authors: Sumin Sun, Sheng Huan, Zhanghao Li, Yue Yao, Ying Su, Siwei Xia, Shijun Wang, Xuefen Xu, Jiangjuan Shao, Zili Zhang, Feng Zhang, Jinbo Fu, Shizhong Zheng

Journal: PeerJ

PubMed ID: 35582617

Doi: 10.7717/peerj.13376

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PI Kinase-EhGEF2-EhRho5 axis contributes to LPA stimulated macropinocytosis in Entamoeba histolytica

Authors: Achala Apte, Maria Manich, Elisabeth Labruyère, Sunando Datta

Journal: PLoS Pathog

PubMed ID: 35594320

Doi: 10.1371/journal.ppat.1010550

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The E3 ubiquitin ligase RNF216/TRIAD3 is a key coordinator of the hypothalamic-pituitary-gonadal axis

Authors: Arlene J George, Bin Dong, Hannah Lail, Morgan Gomez, Yarely C Hoffiz, Christopher B Ware, Ning Fang, Anne Z Murphy, Erik Hrabovszky, Desiree Wanders, Angela M Mabb

Journal: iScience

PubMed ID: 35620441

Doi: 10.1016/j.isci.2022.104386

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Naringenin upregulates GTPCH1/eNOS to ameliorate high glucose-induced retinal endothelial cell injury

Authors: Bing Xue, Yu Wang

Journal: Exp Ther Med

PubMed ID: 35607381

Doi: 10.3892/etm.2022.11355

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Gibbin mesodermal regulation patterns epithelial development

Authors: Ann Collier, Angela Liu, Jessica Torkelson, Jillian Pattison, Sadhana Gaddam, Hanson Zhen, Tiffany Patel, Kelly McCarthy, Hana Ghanim, Anthony E Oro

Journal: Nature

PubMed ID: 35585237

Doi: 10.1038/s41586-022-04727-9

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Immunogenicity and reactogenicity after booster dose with AZD1222 via intradermal route among adult who had received CoronaVac

Authors: Rapisa Nantanee, Puneyavee Aikphaibul, Peera Jaru-Ampornpan, Pimpayao Sodsai, Orawan Himananto, Tuangtip Theerawit, Jiratchaya Sophonphan, Punyot Tovichayathamrong, Kasama Manothummetha, Tysdi Laohasereekul, Narin Hiransuthikul, Nattiya Hirankarn, Thanyawee Puthanakit

Journal: Vaccine

PubMed ID: 35513961

Doi: 10.1016/j.vaccine.2022.04.067

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6-Valent Virus-Like Particle-Based Vaccine Induced Potent and Sustained Immunity Against Noroviruses in Mice

Authors: Wenli Hou, Lihui Lv, Yihan Wang, Man Xing, Yingying Guo, Di Xie, Xin Wei, Xiuyue Zhang, Hui Liu, Jiling Ren, Dongming Zhou

Journal: Front Immunol

PubMed ID: 35711416

Doi: 10.3389/fimmu.2022.906275

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Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia

Authors: Zhi Ruan, Kayo Takamatsu-Yukawa, Yuzhi Wang, Margaret L Ushman, Adam Thomas Labadorf, Maria Ericsson, Seiko Ikezu, Tsuneya Ikezu

Journal: Cell Rep

PubMed ID: 35545052

Doi: 10.1016/j.celrep.2022.110791

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Immune recall improves antibody durability and breadth to SARS-CoV-2 variants

Authors: Yuezhou Chen, Pei Tong, Noah Whiteman, Ali Sanjari Moghaddam, Mehrdad Zarghami, Adam Zuiani, Shaghayegh Habibi, Avneesh Gautam, F Keerti, Caihong Bi, Tianshu Xiao, Yongfei Cai, Bing Chen, Donna Neuberg, Duane R Wesemann

Journal: Sci Immunol

PubMed ID: 35549298

Doi: 10.1126/sciimmunol.abp8328

Products & Services: Proteins, Expression, Isolation and Analysis

Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: a serological analysis

Authors: Frauke Muecksch, Helen Wise, Kate Templeton, Becky Batchelor, Maria Squires, Kirsty McCance, Lisa Jarvis, Kristen Malloy, Elizabeth Furrie, Claire Richardson, Jacqueline MacGuire, Ian Godber, Alana Burns, Sally Mavin, Fengwen Zhang, Fabian Schmidt, Paul D Bieniasz, Sara Jenks, Theodora Hatziioannou

Journal: Lancet Microbe

PubMed ID: 35636436

Doi: 10.1016/S2666-5247(22)00090-8

The dopamine transporter antiports potassium to increase the uptake of dopamine

Authors: Solveig G Schmidt, Mette Galsgaard Malle, Anne Kathrine Nielsen, Søren S-R Bohr, Ciara F Pugh, Jeppe C Nielsen, Ida H Poulsen, Kasper D Rand, Nikos S Hatzakis, Claus J Loland

Journal: Nat Commun

PubMed ID: 35508541

Doi: 10.1038/s41467-022-30154-5

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Rapid 40 kb Genome Construction from 52 Parts through Data-optimized Assembly Design

Authors: John M Pryor, Vladimir Potapov, Katharina Bilotti, Nilisha Pokhrel, Gregory J S Lohman

Journal: ACS Synth Biol

PubMed ID: 35613368

Doi: 10.1021/acssynbio.1c00525

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Extracellular fructooligosaccharide degradation in Anaerostipes hadrus for co-metabolism with non-fructooligosaccharide utilizers

Authors: Akihito Endo, Hiroki Tanno, Ren Kadowaki, Tadashi Fujii, Takumi Tochio

Journal: Biochem Biophys Res Commun

PubMed ID: 35537289

Doi: 10.1016/j.bbrc.2022.04.134

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Electron transfer activity of the nanodisc-bound mitochondrial outer membrane protein mitoNEET

Authors: Homyra Tasnim, Huangen Ding

Journal: Free Radic Biol Med

PubMed ID: 35609862

Doi: 10.1016/j.freeradbiomed.2022.05.011

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Binding Properties of RNA Quadruplex of SARS-CoV-2 to Berberine Compared to Telomeric DNA Quadruplex

Authors: Rosario Oliva, Sanjib Mukherjee, Magiliny Manisegaran, Marco Campanile, Pompea Del Vecchio, Luigi Petraccone, Roland Winter

Journal: Int J Mol Sci

PubMed ID: 35628500

Doi: 10.3390/ijms23105690

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The B-box1 domain of PML mediates SUMO E2-E3 complex formation through an atypical interaction with UBC9

Authors: Thomas Bregnard, Affrin Ahmed, Irina V Semenova, Sandra K Weller, Irina Bezsonova

Journal: Biophys Chem

PubMed ID: 35667129

Doi: 10.1016/j.bpc.2022.106827

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Specific N-glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning

Authors: Maisha Rahman, Nelson J Ramirez-Suarez, Carlos A Diaz-Balzac, Hannes E Bülow

Journal: EMBO Rep

PubMed ID: 35586945

Doi: 10.15252/embr.202154163

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Optical Fluorescence Imaging of Native Proteins Using a Fluorescent Probe with a Cell-Membrane-Permeable Carboxyl Group

Authors: Jung Min Kim, Young-Mi Kang

Journal: Int J Mol Sci

PubMed ID: 35628651

Doi: 10.3390/ijms23105841

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Electrochemical biosensor for rapid detection of fungal contamination in fuel systems

Authors: Osman Radwan, Michael C Brothers, Victoria Coyle, Molly E Chapleau, Richard R Chapleau, Steve S Kim, Oscar N Ruiz

Journal: Biosens Bioelectron

PubMed ID: 35605548

Doi: 10.1016/j.bios.2022.114374

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Exploring Calbindin-IMPase fusion proteins structure and activity

Authors: James W Noble, John R Atack

Journal: Biochem Biophys Rep

PubMed ID: 35540435

Doi: 10.1016/j.bbrep.2022.101266

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OsHUB2 inhibits function of OsTrx1 in heading date in rice

Authors: Zuntao Xu, Enze Li, Gan Xue, Cheng Zhang, Yachun Yang, Yong Ding

Journal: Plant J

PubMed ID: 35395113

Doi: 10.1111/tpj.15763

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Rationally engineering santalene synthase to readjust the component ratio of sandalwood oil

Authors: Wenlong Zha, Fan Zhang, Jiaqi Shao, Xingmei Ma, Jianxun Zhu, Pinghua Sun, Ruibo Wu, Jiachen Zi

Journal: Nat Commun

PubMed ID: 35523896

Doi: 10.1038/s41467-022-30294-8

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LncRNA OIP5-AS1 modulates the proliferation and apoptosis of Jurkat cells by sponging miR-181c-5p to regulate IL-7 expression in myasthenia gravis

Authors: Xu Wang, Huixue Zhang, Xiaoyu Lu, Shuang Li, Xiaotong Kong, Li Liu, Lifang Li, Si Xu, Tianfeng Wang, Jianjian Wang, Lihua Wang

Journal: PeerJ

PubMed ID: 35602889

Doi: 10.7717/peerj.13454

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Development of an LNP-Encapsulated mRNA-RBD Vaccine against SARS-CoV-2 and Its Variants

Authors: Cong Liu, Nino Rcheulishvili, Zhigao Shen, Dimitri Papukashvili, Fengfei Xie, Ziqian Wang, Xingyun Wang, Yunjiao He, Peng George Wang

Journal: Pharmaceutics

PubMed ID: 35631687

Doi: 10.3390/pharmaceutics14051101

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The Inclusion Membrane Protein CTL0390 Mediates Host Cell Exit via Lysis through STING Activation

Authors: R Clayton Bishop, Isabelle Derré

Journal: Infect Immun

PubMed ID: 35587198

Doi: 10.1128/iai.00190-22

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An Ex Vivo 3D Tumor Microenvironment-Mimicry Culture to Study TAM Modulation of Cancer Immunotherapy

Authors: Yan-Ruide Li, Yanqi Yu, Adam Kramer, Ryan Hon, Matthew Wilson, James Brown, Lili Yang

Journal: Cells

PubMed ID: 35563889

Doi: 10.3390/cells11091583

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A Facile Method to Produce N-Terminally Truncated α-Synuclein

Authors: Rebecca J Thrush, Devkee M Vadukul, Francesco A Aprile

Journal: Front Neurosci

PubMed ID: 35692420

Doi: 10.3389/fnins.2022.881480

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Knockout Alleviates DSS-Induced Colitis Regulating the Immune Function of Dendritic Cells

Authors: Wei Wei, Sucheng Mu, Yi Han, Yao Chen, Zhongshu Kuang, Xingyue Wu, Yue Luo, Chaoyang Tong, Yiqun Zhang, Yilin Yang, Zhenju Song

Journal: Front Immunol

PubMed ID: 35669778

Doi: 10.3389/fimmu.2022.841254

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Role of Glutaminase 2 in Promoting CD4+ T Cell Production of Interleukin-2 by Supporting Antioxidant Defense in Systemic Lupus Erythematosus

Authors: Ryo Hisada, Nobuya Yoshida, Seo Yeon K Orite, Masataka Umeda, Catalina Burbano, Marc Scherlinger, Michihito Kono, Suzanne Krishfield, George C Tsokos

Journal: Arthritis Rheumatol

PubMed ID: 35254008

Doi: 10.1002/art.42112

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Homologous or heterogenous vaccination boosters enhance neutralizing activities against SARS-CoV-2 Omicron BA1 variant

Authors: Zhongcheng Zhou, Peng Du, Ning Li, Xinxin Xiong, Shengjun Tang, Qinjin Dai, Taorui Wang, Meixing Yu, Miao Man, Kelvin Lam, Daniel T Baptista-Hon, Wa Hou Tai, Olivia Monteiro, Weng Sam Ng, Un Man Lee, Zhihai Liu, Kang Zhang, Gen Li

Journal: MedComm (2020)

PubMed ID: 35592756

Doi: 10.1002/mco2.143

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Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex

Authors: Heidi Gytz Olesen, Iliana Michailidou, Wioleta M Zelek, Jeroen Vreijling, Patrick Ruizendaal, Ferry de Klein, J Arnoud Marquart, Thomas B Kuipers, Hailiang Mei, Yuchun Zhang, Muhammad Ahasan, Krista K Johnson, Yi Wang, B Paul Morgan, Marcus van Dijk, Kees Fluiter, Gregers Rom Andersen, Frank Baas

Journal: J Innate Immun

PubMed ID: 35551129

Doi: 10.1159/000524587

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[Not Available]

Authors: Kevin Yau, Christopher T Chan, Kento T Abe, Yidi Jiang, Mohammad Atiquzzaman, Sarah I Mullin, Ellen Shadowitz, Lisa Liu, Ema Kostadinovic, Tatjana Sukovic, Anny Gonzalez, Margaret E McGrath-Chong, Matthew J Oliver, Jeffrey Perl, Jerome A Leis, Shelly Bolotin, Vanessa Tran, Adeera Levin, Peter G Blake, Karen Colwill, Anne-Claude Gingras, Michelle A Hladunewich

Journal: CMAJ

PubMed ID: 35636760

Doi: 10.1503/cmaj.211881-f

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Identification of Epitopes on Rhinovirus 89 Capsid Proteins Capable of Inducing Neutralizing Antibodies

Authors: Katarzyna Niespodziana, Clarissa R Cabauatan, Petra Pazderova, Phyllis C Vacal, Judith Wortmann, Walter Keller, Peter Errhalt, Rudolf Valenta

Journal: Int J Mol Sci

PubMed ID: 35563505

Doi: 10.3390/ijms23095113

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Brassica napus genes Rlm4 and Rlm7, conferring resistance to Leptosphaeria maculans, are alleles of the Rlm9 wall-associated kinase-like resistance locus

Authors: Parham Haddadi, Nicholas J Larkan, Angela Van deWouw, Yueqi Zhang, Ting Xiang Neik, Elena Beynon, Philipp Bayer, Dave Edwards, Jacqueline Batley, Mohammad Hossein Borhan

Journal: Plant Biotechnol J

PubMed ID: 35338565

Doi: 10.1111/pbi.13818

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Influence of Cortisol on the Fibril Formation Kinetics of Aβ42 Peptide: A Multi-Technical Approach

Authors: Alessandro Nucara, Francesca Ripanti, Simona Sennato, Giacomo Nisini, Emiliano De Santis, Mahta Sefat, Marina Carbonaro, Dalila Mango, Velia Minicozzi, Marilena Carbone

Journal: Int J Mol Sci

PubMed ID: 35682687

Doi: 10.3390/ijms23116007

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Cryo-EM structures of the human surfactant lipid transporter ABCA3

Authors: Tian Xie, Zike Zhang, Jian Yue, Qi Fang, Xin Gong

Journal: Sci Adv

PubMed ID: 35394827

Doi: doi/10.1126/sciadv.abn3727

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LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs

Authors: Marina N Iriondo , Asier Etxaniz , Yaiza R Varela , Uxue Ballesteros , Javier H Hervás , L Ruth Montes , Félix M Goñi , Alicia Alonso

Journal: Autophagy

PubMed ID: 35414338

Doi: 10.1080/15548627.2022.2062111

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Amyloid fishing: β-Amyloid adsorption using tailor-made coated titania nanoparticles

Authors: Elad Arad , Raz Jelinek , Hanna Rapaport

Journal: Colloids Surf B Biointerfaces

PubMed ID: 35121429

Doi: 10.1016/j.colsurfb.2022.112374

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Targeting intrinsically disordered regions facilitates discovery of CaV3.2 inhibitory peptides for AAV-mediated peripheral analgesia

Authors: Seung Min Shin , Justas Lauzadis , Brandon Itson-Zoske , Yongsong Cai 1 , Fan Fan , Gayathri Natarajan , Wai-Meng Kwok , Michelino Puopolo , Quinn H Hogan , Hongwei Yu

Journal: Pain

PubMed ID: 35420557

Doi: 10.1097/j.pain.0000000000002650

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Specific knockdown of by CRISPR-CasRx prevents acquired sensorineural hearing loss in mice

Authors: Yang Guo, Lei Han, Shuang Han, Honghai Tang, Shengyi Wang, Chong Cui, Bing Chen, Huawei Li, Yilai Shu

Journal: Mol Ther Nucleic Acids

PubMed ID: 35615000

Doi: 10.1016/j.omtn.2022.04.014

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Immmunoinformatics-based design of a multi-epitope vaccine with CTLA-4 extracellular domain to combat Helicobacter pylori

Authors: Zhenyu Ru, Mingkai Yu, Yuejie Zhu, Zhiqiang Chen, Fengbo Zhang, Zhiqiang Zhang, Jianbing Ding

Journal: FASEB J

PubMed ID: 35294065

Doi: 10.1096/fj.202101538RR

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p53 alters intracellular Ca signaling through regulation of TRPM4

Authors: Sven Kappel, Daniela Ross-Kaschitza, Barbara Hauert, Karen Rother, Christine Peinelt

Journal: Cell Calcium

PubMed ID: 35500522

Doi: 10.1016/j.ceca.2022.102591

Products & Services: Proteins, Expression, Isolation and Analysis

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