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Enhancing fluxes through the mevalonate pathway in Saccharomyces cerevisiae by engineering the HMGR and β-alanine metabolism

Authors: Surui Lu, Chenyao Zhou, Xuena Guo, Zhengda Du, Yanfei Cheng, Zhaoyue Wang, Xiuping He

Journal: Microb Biotechnol

PubMed ID: 35531990

Doi: 10.1111/1751-7915.14072

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Smartly responsive DNA-miRNA hybrids packaged in exosomes for synergistic enhancement of cancer cell apoptosis

Authors: Fan Zhang, Albertina N Isak, Shiqi Yang, Yuchen Song, Lingjie Ren, Chang Feng, Guifang Chen

Journal: Nanoscale

PubMed ID: 35421879

Doi: 10.1039/d1nr08539e

Products & Services: Gene Synthesis

Glutathione S-transferase: a candidate gene for berry color in muscadine grapes (Vitis rotundifolia)

Authors: Aruna Varanasi, Margaret Worthington, Lacy Nelson, Autumn Brown, Thomas Mason Chizk, Renee Threlfall, Luke Howard, Patrick Conner, Rosa Figueroa-Balderas, Mélanie Massonnet, Dario Cantu, John R Clark

Journal: G3 (Bethesda)

PubMed ID: 35302606

Doi: 10.1093/g3journal/jkac060

Products & Services: PCR and Cloning

Crosstalk between IL-15Rα tumor-associated macrophages and breast cancer cells reduces CD8 T cell recruitment

Authors: Wenlong Zhang, Qing Zhang, Nanfei Yang, Qian Shi, Huifang Su, Tingsheng Lin, Zhonglei He, Wenxin Wang, Hongqian Guo, Pingping Shen

Journal: Cancer Commun (Lond)

PubMed ID: 35615815

Doi: 10.1002/cac2.12311

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A Novel Ig Domain-Containing C-Type Lectin Triggers the Intestine-Hemocyte Axis to Regulate Antibacterial Immunity in Crab

Authors: Kaimin Zhou, Yukai Qin, Yu Song, Ke Zhao, Weijuan Pan, Xingyu Nan, Yue Wang, Qun Wang, Weiwei Li

Journal: J Immunol

PubMed ID: 35508356

Doi: 10.4049/jimmunol.2101027

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Self-Assembling Nanovaccine Confers Complete Protection Against Zika Virus Without Causing Antibody-Dependent Enhancement

Authors: Heng Rong, Mi Qi, Jingdi Pan, Yuhan Sun, Jiawang Gao, Xiaowei Zhang, Wei Li, Bo Zhang, Xian-En Zhang, Zongqiang Cui

Journal: Front Immunol

PubMed ID: 35615356

Doi: 10.3389/fimmu.2022.905431

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Structural basis of sodium-dependent bile salt uptake into the liver

Authors: Kapil Goutam, Francesco S Ielasi, Els Pardon, Jan Steyaert, Nicolas Reyes

Journal: Nature

PubMed ID: 35545671

Doi: 10.1038/s41586-022-04723-z

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Duo Cadherin-Functionalized Microparticles Synergistically Induce Chondrogenesis and Cartilage Repair of Stem Cell Aggregates

Authors: Xueping Wang, Xingquan Xu, Yan Zhang, Xueying An, Xue Zhang, Guoqiang Chen, Qing Jiang, Jun Yang

Journal: Adv Healthc Mater

PubMed ID: 35485302

Doi: 10.1002/adhm.202200246

Products & Services: Mammalian Expression

Revisiting misfolding propensity of serum amyloid A1: Special focus on the signal peptide region

Authors: Morgan S Haines, Eduardo Ramirez, Kendall B E Moore, Jessica S Fortin

Journal: Biochem Biophys Rep

PubMed ID: 35664543

Doi: 10.1016/j.bbrep.2022.101284

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Antibodies targeting the European lobster (Palinurus elephas) vitellogenin developed by mRNA isolation and in-silico-designed antigenic peptides

Authors: Faustina B Cannea, Maria Cristina Follesa, Cristina Porcu, Rossano Rossino, Alessandra Olianas, Antonio Rescigno, Alessandra Padiglia

Journal: Biol Open

PubMed ID: 35452506

Doi: 10.1242/bio.059019

Products & Services: Peptide Synthesis

Small, charged proteins in salmon louse (Lepeophtheirus salmonis) secretions modulate Atlantic salmon (Salmo salar) immune responses and coagulation

Authors: Aina-Cathrine Øvergård, Helena M D Midtbø, Lars A Hamre, Michael Dondrup, Gro E K Bjerga, Øivind Larsen, Jiwan Kumar Chettri, Kurt Buchmann, Frank Nilsen, Sindre Grotmol

Journal: Sci Rep

PubMed ID: 35568726

Doi: 10.1038/s41598-022-11773-w

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Functional validation of a novel AAAS variant in an atypical presentation of Allgrove syndrome

Authors: Erica L Macke, Joel A Morales-Rosado, Sarah K Macklin-Mantia, Christopher T Schmitz, Björn Oskarsson, Eric W Klee, Klaas J Wierenga

Journal: Mol Genet Genomic Med

PubMed ID: 35570467

Doi: 10.1002/mgg3.1966

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SARS-CoV-2 BA1 variant is neutralized by vaccine booster-elicited serum but evades most convalescent serum and therapeutic antibodies

Authors: Sabrina Lusvarghi, Simon D Pollett, Sabari Nath Neerukonda, Wei Wang, Richard Wang, Russell Vassell, Nusrat J Epsi, Anthony C Fries, Brian K Agan, David A Lindholm, Christopher J Colombo, Rupal Mody, Evan C Ewers, Tahaniyat Lalani, Anuradha Ganesan, Emilie Goguet, Monique Hollis-Perry, Si'Ana A Coggins, Mark P Simons, Leah C Katzelnick, Gregory Wang, David R Tribble, Lisa Bentley, Ann E Eakin, Christopher C Broder, Karl J Erlandson, Eric D Laing, Timothy H Burgess, Edward Mitre, Carol D Weiss

Journal: Sci Transl Med

PubMed ID: 35380448

Doi: 10.1126/scitranslmed.abn8543

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Lactoferrin Inhibition of the Complex Formation between ACE2 Receptor and SARS CoV-2 Recognition Binding Domain

Authors: Roberta Piacentini, Laura Centi, Mattia Miotto, Edoardo Milanetti, Lorenzo Di Rienzo, Martina Pitea, Paolo Piazza, Giancarlo Ruocco, Alberto Boffi, Giacomo Parisi

Journal: Int J Mol Sci

PubMed ID: 35628247

Doi: 10.3390/ijms23105436

Products & Services: Proteins, Expression, Isolation and Analysis

Computational approach for binding prediction of SARS-CoV-2 with neutralizing antibodies

Authors: Daria Beshnova, Yan Fang, Mingjian Du, Yehui Sun, Fenghe Du, Jianfeng Ye, Zhijian James Chen, Bo Li

Journal: Comput Struct Biotechnol J

PubMed ID: 35530743

Doi: 10.1016/j.csbj.2022.04.038

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α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins

Authors: Weidong Jing, Jordan Lo Pilato, Callum Kay, Shouya Feng, Daniel Enosi Tuipulotu, Anukriti Mathur, Cheng Shen, Chinh Ngo, Anyang Zhao, Lisa A Miosge, Sidra A Ali, Elizabeth E Gardiner, Milena M Awad, Dena Lyras, Avril A B Robertson, Nadeem O Kaakoush, Si Ming Man

Journal: Sci Immunol

PubMed ID: 35594341

Doi: 10.1126/sciimmunol.abm1803

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An Immunoinformatic Strategy to Develop New Multi-epitope Vaccine

Authors:

Journal: INT J PEPT RES THER

PubMed ID: 35573911

Doi: 10.1007/s10989-022-10406-0

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Constitutively Active STAT5b Feminizes Mouse Liver Gene Expression

Authors: Dana Lau-Corona, Hong Ma, Cameron Vergato, Andre Sarmento-Cabral, Mercedes Del Rio-Moreno, Rhonda D Kineman, David J Waxman

Journal: Endocrinology

PubMed ID: 35396838

Doi: 10.1210/endocr/bqac046

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Characterization of a New Multifunctional GH20 β--Acetylglucosaminidase From sp GC72 and Its Application in Converting Chitin Into Acetyl Glucosamine

Authors: Yan Chen, Ning Zhou, Xueman Chen, Guoguang Wei, Alei Zhang, Kequan Chen, Pingkai Ouyang

Journal: Front Microbiol

PubMed ID: 35620090

Doi: 10.3389/fmicb.2022.874908

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Lentiviral gene therapy prevents anti-human acid α-glucosidase antibody formation in murine Pompe disease

Authors: Qiushi Liang, Eva C Vlaar, Fabio Catalano, Joon M Pijnenburg, Merel Stok, Yvette van Helsdingen, Arnold G Vulto, Wendy W J Unger, Ans T van der Ploeg, W W M Pim Pijnappel, Niek P van Til

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35662813

Doi: 10.1016/j.omtm.2022.04.016

Products & Services: Mammalian Expression

Biosynthesis of valerenic acid by engineered Saccharomyces cerevisiae

Authors: Mengya Zhao, Chuanbo Zhang, Haibin Wang, Shifan He, Wenyu Lu

Journal: Biotechnol Lett

PubMed ID: 35643816

Doi: 10.1007/s10529-022-03264-9

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A proof-of-concept study on the use of a fluorescein-based 18F-tracer for pretargeted PET

Authors: Hugo Helbert , Emily M Ploeg , Douwe F Samplonius , Simon N Blok , Ines F Antunes , Verena I Böhmer , Gert Luurtsema , Rudi A J O Dierckx , Ben L Feringa , Philip H Elsinga , Wiktor Szymanski , Wijnand Helfrich

Journal: EJNMMI Radiopharm Chem .

PubMed ID: 35239034

Doi: 10.1186/s41181-022-00155-2

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Cell-Penetrating Peptide TAT-HuR-HNS3 Suppresses Proinflammatory Gene Expression via Competitively Blocking Interaction of HuR with Its Partners

Authors: Ke Wang, Haibin Tong, Yitian Gao, Lan Xia, Xin Jin, Xiaoxue Li, Xianlu Zeng, Istvan Boldogh, Yueshuang Ke, Xueqing Ba

Journal: J Immunol

PubMed ID: 35444028

Doi: 10.4049/jimmunol.2200002

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Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast

Authors: Tengfei Liu , Yuanwei Gou , Bei Zhang , Rui Gao , Chang Dong , Mingming Qi , Lihong Jiang , Xuanwei Ding , Chun Li , Jiazhang Lian

Journal: Biotechnol Bioeng

PubMed ID: 35060115

Doi: doi.org/10.1002/bit.28040

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Thioester-Assisted Sortase-A - Mediated Ligation

Authors: Chong Zuo 1, Ruichao Ding 1, Xiangwei Wu , Yuanxia Wang , Guo-Chao Chu, Lu-Jun Liang, Huasong Ai ， Ze-Bin Tong , Junxiong Mao , Qingyun Zheng , Tian Wang , Zichen Li , Lei Liu, Demeng Sun

Journal: Angew Chem Int Ed Engl

PubMed ID: 35514243

Doi: 10.1002/anie.202201887

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An Arabidopsis pre-RNA processing8a (prp8a) missense allele restores splicing of a subset of mis-spliced mRNAs

Authors: Roxanna J Llinas , Jia Qi Xiong , Natalie M Clark , Sarah E Burkhart , Bonnie Bartel

Journal: Plant Physiol

PubMed ID: 35608297

Doi: 10.1093/plphys/kiac221

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Adaptation-Proof SARS-CoV-2 Vaccine Design

Authors: Yashavantha L Vishweshwaraiah, Brianna Hnath, Brendan Rackley, Jian Wang, Abhinay Gontu, Morgan Chandler, Kirill A Afonin, Suresh V Kuchipudi, Neil Christensen, Neela H Yennawar, Nikolay V Dokholyan

Journal: biorxiv

PubMed ID: 35611332

Doi: doi.org/10.1002/adfm.202206055

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Effective-Component Compatibility of Bufei Yishen Formula III Combined with Electroacupuncture Suppresses Inflammatory Response in Rats with Chronic Obstructive Pulmonary Disease via Regulating SIRT1/NF-B Signaling

Authors: Fanli Jin, Lanxi Zhang, Kai Chen, Yufang Miao, Yang Liu, Yange Tian, Jiansheng Li

Journal: Biomed Res Int

PubMed ID: 35586807

Doi: 10.1155/2022/3360771

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3,5,3'-Triiodothyronine-Loaded Liposomes Inhibit Hepatocarcinogenesis Inflammation-Associated Macrophages

Authors: Gangqi Sun, Xiaojuan Hou, Luyao Zhang, Hengyan Zhang, Changchun Shao, Fengwei Li, Chen Zong, Rong Li, Junxia Shi, Xue Yang, Li Zhang

Journal: Front Oncol

PubMed ID: 35646705

Doi: 10.3389/fonc.2022.877982

Products & Services: Proteins, Expression, Isolation and Analysis

Identification and Functional Characterization of Peptides With Antimicrobial Activity From the Syphilis Spirochete,

Authors: Simon Houston, Ethan Schovanek, Kate M E Conway, Sarah Mustafa, Alloysius Gomez, Raghavendran Ramaswamy, Ayman Haimour, Martin J Boulanger, Lisa A Reynolds, Caroline E Cameron

Journal: Front Microbiol

PubMed ID: 35722306

Doi: 10.3389/fmicb.2022.888525

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Carboxymethylcellulose biofunctionalized ternary quantum dots for subcellular-targeted brain cancer nanotheranostics

Authors: Alexandra A P Mansur, Mayara R B Paiva, Oliver A L Cotta, Luciana M Silva, Isadora C Carvalho, Nádia S V Capanema, Sandhra M Carvalho, Érica A Costa, Nelson R Martin, Roselene Ecco, Beatriz S Santos, Silvia L Fialho, Zélia I P Lobato, Herman S Mansur

Journal: Int J Biol Macromol

PubMed ID: 35513094

Doi: 10.1016/j.ijbiomac.2022.04.207

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The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors

Authors: Robert D Murphy, Tiantian Chen, Jianping Lin, Rongjun He, Li Wu, Caden R Pearson, Savita Sharma, Carl D Vander Kooi, Anthony P Sinai, Zhong-Yin Zhang, Craig W Vander Kooi, Matthew S Gentry

Journal: J Biol Chem

PubMed ID: 35640720

Doi: 10.1016/j.jbc.2022.102089

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Phosphatidylinositol transfer protein/planar cell polarity axis regulates neocortical morphogenesis by supporting interkinetic nuclear migration

Authors: Zhigang Xie, Vytas A Bankaitis

Journal: Cell Rep

PubMed ID: 35649377

Doi: 10.1016/j.celrep.2022.110869

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Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet

Authors: Hong Lu, Xiaohong Lei, Rebecca Winkler, Savio John, Devendra Kumar, Wenkuan Li, Yazen Alnouti

Journal: Lipids Health Dis

PubMed ID: 35614477

Doi: 10.1186/s12944-022-01654-6

Products & Services: Mutagenesis Services

Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants

Authors: Lili Li, Meiling Gao, Peng Jiao, Shulong Zu, Yong-Qiang Deng, Dingyi Wan, Yang Cao, Jing Duan, Saba R Aliyari, Jie Li, Yueyue Shi, Zihe Rao, Cheng-Feng Qin, Yu Guo, Genhong Cheng, Heng Yang

Journal: Cell Biosci

PubMed ID: 35581593

Doi: 10.1186/s13578-022-00794-7

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Identification, expression and subcellular localization of Orc1 in the microsporidian Nosema bombycis

Authors: Fuzhen Sun, Guanyu Zhu, Ping He, Erjun Wei, Runpeng Wang, Qiang Wang, Xudong Tang, Yiling Zhang, Zhongyuan Shen

Journal: Gene

PubMed ID: 35609797

Doi: 10.1016/j.gene.2022.146607

Products & Services: Proteins, Expression, Isolation and Analysis

Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment

Authors: Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Martha Minjárez-Sáenz, Javier Macías-León, Blanca Conde, Javier Raso, Ramón Hurtado-Guerrero, Alberto Anel

Journal: Biomedicines

PubMed ID: 35740244

Doi: 10.3390/biomedicines10061223

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A minimal bile salt excretory pump promoter allows bile acid-driven physiological regulation of transgene expression from a gene therapy vector

Authors: Javier Martínez-García, Manuela Molina, Leticia Odriozola, Angie Molina, Gloria González-Aseguinolaza, Nicholas D Weber, Cristian Smerdou

Journal: Cell Biosci

PubMed ID: 35641984

Doi: 10.1186/s13578-022-00803-9

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Electrostatics Drive the Molecular Chaperone BiP to Preferentially Bind Oligomerized States of a Client Protein

Authors: Erin E Deans, Judy L M Kotler, Wei-Shao Wei, Timothy O Street

Journal: J Mol Biol

PubMed ID: 35597552

Doi: 10.1016/j.jmb.2022.167638

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Atypical B cells up-regulate costimulatory molecules during malaria and secrete antibodies with T follicular helper cell support

Authors: Christine S Hopp, Jeff Skinner, Sarah L Anzick, Christopher M Tipton, Mary E Peterson, Shanping Li, Safiatou Doumbo, Kassoum Kayentao, Aissata Ongoiba, Craig Martens, Boubacar Traore, Peter D Crompton

Journal: Sci Immunol

PubMed ID: 35559666

Doi: 10.1126/sciimmunol.abn1250

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Candidate Chemosensory Genes Identified in the Adult Antennae of and Binding Property of Odorant-Binding Protein 15

Authors: Xiao Li, Jian-Wen Li, Wen-Xiu Sun, Wei Li, Hua-Yuan Gao, Tong-Xian Liu, Ming-Jing Qu

Journal: Front Physiol

PubMed ID: 35711318

Doi: 10.3389/fphys.2022.907667

Products & Services: Proteins, Expression, Isolation and Analysis

Structural variation between neuropeptide isoforms affects function in the lobster cardiac system

Authors: Audrey J Muscato, Daniel J Powell, Warsameh Bulhan, Evalyn S Mackenzie, Alixander Pupo, Madeline Rolph, Andrew E Christie, Patsy S Dickinson

Journal: Gen Comp Endocrinol

PubMed ID: 35623446

Doi: 10.1016/j.ygcen.2022.114065

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Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation

Authors: Robert Blassberg, Harshil Patel, Thomas Watson, Mina Gouti, Vicki Metzis, M Joaquina Delás, James Briscoe

Journal: Nat Cell Biol

PubMed ID: 35550614

Doi: 10.1038/s41556-022-00910-2

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The CD8α hinge is intrinsically disordered with a dynamic exchange that includes proline cis-trans isomerization

Authors: Xiang Chen, Justin M Mirazee, Katarzyna A Skorupka, Hiroshi Matsuo, Philippe Youkharibache, Naomi Taylor, Kylie J Walters

Journal: J Magn Reson

PubMed ID: 35617919

Doi: 10.1016/j.jmr.2022.107234

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SOLVx therapeutics vaccine - Activate T-cell immunity using broad surveillance epitope strategy against mutant strains SARS-COV2

Authors: Md Shamsuddin Sultan Khan, John A Catanzaro

Journal: Biomed Pharmacother

PubMed ID: 35653885

Doi: 10.1016/j.biopha.2022.113212

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CBR3-AS1 Accelerates the Malignant Proliferation of Gestational Choriocarcinoma Cells by Stabilizing SETD4

Authors: Yajuan Zhang, Hongxiu Zhang, Xiaolei Zhang, Bin Liu

Journal: Dis Markers

PubMed ID: 35655916

Doi: 10.1155/2022/7155525

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IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes

Authors: Jose L Garrido, Matías A Medina, Felipe Bravo, Sarah McGee, Francisco Fuentes-Villalobos, Mario Calvo, Yazmin Pinos, James W Bowman, Christopher D Bahl, Maria Ines Barria, Rebecca A Brachman, Raymond A Alvarez

Journal: Cell Rep

PubMed ID: 35617962

Doi: 10.1016/j.celrep.2022.110904

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Thymosin α-1 Reverses M2 Polarization of Tumor-Associated Macrophages during Efferocytosis

Authors: Yi-Ting Wei, Xu-Ru Wang, Chunguang Yan, Fang Huang, Yunpeng Zhang, Xueming Liu, Zhi-Fa Wen, Xiao-Tong Sun, Yue Zhang, Yong-Qiang Chen, Rong Gao, Ning Pan, Li-Xin Wang

Journal: Cancer Res

PubMed ID: 35364609

Doi: 10.1158/0008-5472.CAN-21-4260

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BCG-Based Vaccines Elicit Antigen-Specific Adaptive and Trained Immunity against SARS-CoV-2 and

Authors: Jorge A Soto, Fabián E Díaz, Angello Retamal-Díaz, Nicolás M S Gálvez, Felipe Melo-González, Alejandro Piña-Iturbe, Mario A Ramírez, Karen Bohmwald, Pablo A González, Susan M Bueno, Alexis M Kalergis

Journal: Vaccines (Basel)

PubMed ID: 35632475

Doi: 10.3390/vaccines10050721

Products & Services: Proteins, Expression, Isolation and Analysis

Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein

Authors: M Alejandra Tortorici, Alexandra C Walls, Anshu Joshi, Young-Jun Park, Rachel T Eguia, Marcos C Miranda, Elizabeth Kepl, Annie Dosey, Terry Stevens-Ayers, Michael J Boeckh, Amalio Telenti, Antonio Lanzavecchia, Neil P King, Davide Corti, Jesse D Bloom, David Veesler

Journal: Cell

PubMed ID: 35700730

Doi: 10.1016/j.cell.2022.05.019

Products & Services: Mammalian Expression

Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen

Authors: Zaid Taha, Rozanne Arulanandam, Glib Maznyi, Elena Godbout, Madalina E Carter-Timofte, Naziia Kurmasheva, Line S Reinert, Andrew Chen, Mathieu J F Crupi, Stephen Boulton, Geneviève Laroche, Alexandra Phan, Reza Rezaei, Nouf Alluqmani, Anna Jirovec, Alexandra Acal, Emily E F Brown, Ragunath Singaravelu, Julia Petryk, Manja Idorn, Kyle G Potts, Hayley Todesco, Cini John, Douglas J Mahoney, Carolina S Ilkow, Patrick Giguère, Tommy Alain, Marceline Côté, Søren R Paludan, David Olagnier, John C Bell, Taha Azad, Jean-Simon Diallo

Journal: Mol Ther

PubMed ID: 35526097

Doi: 10.1016/j.ymthe.2022.04.025

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BpEIN31 represses leaf senescence by inhibiting synthesis of ethylene and abscisic acid in Betula platyphylla

Authors: Shiyu Song, Mengyan Ge, Wei Wang, Chenrui Gu, Kun Chen, Qingzhu Zhang, Qibin Yu, Guifeng Liu, Jing Jiang

Journal: Plant Sci

PubMed ID: 35696929

Doi: 10.1016/j.plantsci.2022.111330

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Cancer genomic profiling identified dihydropyrimidine dehydrogenase deficiency in bladder cancer promotes sensitivity to gemcitabine

Authors: Shigehiro Tsukahara, Masaki Shiota, Dai Takamatsu, Shohei Nagakawa, Takashi Matsumoto, Ryo Kiyokoba, Mikako Yagi, Daiki Setoyama, Nozomi Noda, Shinya Matsumoto, Tetsutaro Hayashi, Alberto Contreras-Sanz, Peter C Black, Junichi Inokuchi, Kenichi Kohashi, Yoshinao Oda, Takeshi Uchiumi, Masatoshi Eto, Dongchon Kang

Journal: Sci Rep

PubMed ID: 35595780

Doi: 10.1038/s41598-022-12528-3

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LncRNA JPX Promotes Esophageal Squamous Cell Carcinoma Progression by Targeting miR-516b-5p/VEGFA Axis

Authors: Yi He, Rong Hua, Yang Yang, Bin Li, Xufeng Guo, Zhigang Li

Journal: Cancers (Basel)

PubMed ID: 35681693

Doi: 10.3390/cancers14112713

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Analysis of rhodopsin G protein-coupled receptor orthologs reveals semiochemical peptides for parasite (Schistosoma mansoni) and host (Biomphalaria glabrata) interplay

Authors: Phong Phan, Di Liang, Min Zhao, Russell C Wyeth, Conor Fogarty, Mary G Duke, Donald P McManus, Tianfang Wang, Scott F Cummins

Journal: Sci Rep

PubMed ID: 35581232

Doi: 10.1038/s41598-022-11996-x

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Patients with treated indolent lymphomas immunized with BNT162b2 have reduced anti-spike neutralizing IgG to SARS-CoV-2 variants, but preserved antigen-specific T cell responses

Authors: Brendan Beaton, Sarah C Sasson, Katherine Rankin, Juliette Raedemaeker, Alexander Wong, Priyanka Hastak, Chansavath Phetsouphanh, Andrew Warden, Vera Klemm, C Mee Ling Munier, Alexandra Carey Hoppe, Fiona Tea, Aleha Pillay, Alberto Ospina Stella, Anupriya Aggarwal, Orly Lavee, Ian D Caterson, Stuart Turville, Anthony D Kelleher, Fabienne Brilot, Judith Trotman

Journal: Am J Hematol

PubMed ID: 35607995

Doi: 10.1002/ajh.26619

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Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/β-catenin signaling in mammals

Authors: Zhi Liu, Tian Chen, Sicheng Zhang, Tianfang Yang, Yun Gong, Hong-Wen Deng, Ding Bai, Weidong Tian, YiPing Chen

Journal: Elife

PubMed ID: 35503096

Doi: 10.7554/eLife.77740

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Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3

Authors: Qing Zhang, Jun Ren, Fangfang Wang, Manman Pan, Long Cui, Mingqian Li, Fan Qu

Journal: Free Radic Biol Med

PubMed ID: 35594990

Doi: 10.1016/j.freeradbiomed.2022.05.010

Products & Services: Proteins, Expression, Isolation and Analysis

A Transfected Parasite Line Expressing eGFP Is Able to Complete the Full Life Cycle of the Parasite in Mammalian and Tick Hosts

Authors: Wendell C Johnson, Hala E Hussein, Janaina Capelli-Peixoto, Jacob M Laughery, Naomi S Taus, Carlos E Suarez, Massaro W Ueti

Journal: Pathogens

PubMed ID: 35745477

Doi: 10.3390/pathogens11060623

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Multiple stem-loop primers induced cascaded loop-mediated isothermal amplification for direct recognition and specific detection of circular RNAs

Authors: Xin Liu, Pengbo Zhang, Kejian Gao, Xiaoyu Wang, Zhengping Li

Journal: Analyst

PubMed ID: 35506753

Doi: 10.1039/d2an00261b

Products & Services: Proteins, Expression, Isolation and Analysis

An aggregation-induced emission immunoassay for broad detection of polychlorinated biphenyls in chicken and crab

Authors: Chang Han, Yulong Wang, Pengyan Liu, Pan Li, Beibei Liu, Ning Ding, Michael N Routledge, Zhengjiang Liu, Cunzheng Zhang

Journal: Anal Bioanal Chem

PubMed ID: 35606453

Doi: 10.1007/s00216-022-04123-2

Products & Services: Proteins, Expression, Isolation and Analysis

SERCA interacts with chitin synthase and participates in cuticular chitin biogenesis in Drosophila

Authors: Weixing Zhu, Yanwei Duan, Jiqiang Chen, Hans Merzendorfer, Xu Zou, Qing Yang

Journal: Insect Biochem Mol Biol

PubMed ID: 35525402

Doi: 10.1016/j.ibmb.2022.103783

Products & Services: Proteins, Expression, Isolation and Analysis

Are Hamsters a Suitable Model for Evaluating the Immunogenicity of RBD-Based Anti-COVID-19 Subunit Vaccines?

Authors: Iuliia A Merkuleva, Dmitry N Shcherbakov, Mariya B Borgoyakova, Anastasiya A Isaeva, Valentina S Nesmeyanova, Natalia V Volkova, Vazirbek S Aripov, Daniil V Shanshin, Larisa I Karpenko, Svetlana V Belenkaya, Elena I Kazachinskaia, Ekaterina A Volosnikova, Tatiana I Esina, Alexandr A Sergeev, Kseniia A Titova, Yulia V Konyakhina, Anna V Zaykovskaya, Oleg V Pyankov, Evgeniia A Kolosova, Olesya E Viktorina, Arseniya A Shelemba, Andrey P Rudometov, Alexander A Ilyichev

Journal: Viruses

PubMed ID: 35632800

Doi: 10.3390/v14051060

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Development of DNA Vaccine Candidate against SARS-CoV-2

Authors: Xingyun Wang, Nino Rcheulishvili, Jie Cai, Cong Liu, Fengfei Xie, Xing Hu, Nuo Yang, Mengqi Hou, Dimitri Papukashvili, Yunjiao He, Peng George Wang

Journal: Viruses

PubMed ID: 35632789

Doi: 10.3390/v14051049

Complementary Roles of Antibody Heavy and Light Chain Somatic Hypermutation in Conferring Breadth and Potency to the HIV-1-Specific CAP256-VRC26 bNAb Lineage

Authors: David Sacks, Kevin Wiehe, Lynn Morris, Penny L Moore

Journal: J Virol

PubMed ID: 35510865

Doi: 10.1128/jvi.00270-22

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OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage

Authors: Xiaoli S Wu, Xue-Yan He, Jonathan J Ipsaro, Yu-Han Huang, Jonathan B Preall, David Ng, Yan Ting Shue, Julien Sage, Mikala Egeblad, Leemor Joshua-Tor, Christopher R Vakoc

Journal: Nature

PubMed ID: 35576971

Doi: 10.1038/s41586-022-04842-7

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Characterization of the Biomass Degrading Enzyme GuxA from

Authors: Neal N Hengge, Sam J B Mallinson, Patthra Pason, Vladimir V Lunin, Markus Alahuhta, Daehwan Chung, Michael E Himmel, Janet Westpheling, Yannick J Bomble

Journal: Int J Mol Sci

PubMed ID: 35682749

Doi: 10.3390/ijms23116070

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Tuaimenal A, a Meroterpene from the Irish Deep-Sea Soft Coral , Displays Inhibition of the SARS-CoV-2 3CLpro Enzyme

Authors: Nicole E Avalon, Jordan Nafie, Carolina De Marco Verissimo, Luke C Warrensford, Sarah G Dietrick, Amanda R Pittman, Ryan M Young, Fiona L Kearns, Tracess Smalley, Jennifer M Binning, John P Dalton, Mark P Johnson, H Lee Woodcock, A Louise Allcock, Bill J Baker

Journal: J Nat Prod

PubMed ID: 35549259

Doi: 10.1021/acs.jnatprod.2c00054

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A paper-based optical sensor for the screening of viruses through the cysteine residues of their surface proteins: A proof of concept on the detection of coronavirus infection

Authors: Mahnaz D Gholami, Kristyan Guppy-Coles, Serena Nihal, Daman Langguth, Prashant Sonar, Godwin A Ayoko, Chamindie Punyadeera, Emad L Izake

Journal: Talanta

PubMed ID: 35660992

Doi: 10.1016/j.talanta.2022.123630

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Immunoinformatic approach for the construction of multi-epitopes vaccine against omicron COVID-19 variant

Authors: Kanwal Khan, Salman Ali Khan, Khurshid Jalal, Zaheer Ul-Haq, Reaz Uddin

Journal: Virology

PubMed ID: 35576833

Doi: 10.1016/j.virol.2022.05.001

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Efficacy, T cell activation and antibody responses in accelerated Plasmodium falciparum sporozoite chemoprophylaxis vaccine regimens

Authors: Javier Ibanez, Rolf Fendel, Freia-Raphaella Lorenz, Patricia Granados-Bayon, Sina Brückner, Meral Esen, Mihály Sulyok, Zita Sulyok, Steffen Borrmann, Petra Bacher, Alexander Scheffold, Stephen L Hoffman, Peter G Kremsner, Benjamin Mordmüller

Journal: npj Vaccines

PubMed ID: 35641527

Doi: 10.1038/s41541-022-00473-1

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Elimination of a closed population of the yellow fever mosquito, Aedes aegypti, through releases of self-limiting male mosquitoes

Authors: Prabhakargouda B Patil, Shaibal Kumar Dasgupta, Kevin Gorman, Angela Pickl-Herk, Mirel Puinean, Andrew McKemey, Bharat Char, Usha B Zehr, Shirish R Barwale

Journal: PLoS Negl Trop Dis

PubMed ID: 35576193

Doi: 10.1371/journal.pntd.0010315

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The Carotenoid Esterification Gene Controls Pale-Yellow Petal Color in Flowering Chinese Cabbage ( L subsp )

Authors: Peirong Li, Sirui Lv, Deshuang Zhang, Tongbing Su, Xiaoyun Xin, Weihong Wang, Xiuyun Zhao, Yangjun Yu, Yaowei Zhang, Shuancang Yu, Fenglan Zhang

Journal: Front Plant Sci

PubMed ID: 35592555

Doi: 10.3389/fpls.2022.844140

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Novel small molecules targeting bZIP23 TF improve stomatal conductance and photosynthesis under mild drought stress by regulating ABA

Authors: Vanitha Pa, Preethi Vijayaraghavareddy, Akshay Uttarkar, Akashata Dawane, Sujitha D, Ashwin V, Babitha Kc, Vidya Niranjan, Sheshshayee Ms, Anuradha Cv, Udayakumar Makarla, Ramu S Vemanna

Journal: FEBS J

PubMed ID: 35445538

Doi: 10.1111/febs.16461

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Mammalian Display Platform for the Maturation of Bispecific TCR-Based Molecules

Authors: Janine Dilchert, Martin Hofmann, Felix Unverdorben, Roland Kontermann, Sebastian Bunk

Journal: Antibodies (Basel)

PubMed ID: 35645207

Doi: 10.3390/antib11020034

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Randomizing of Oligopeptide Conformations by Nearest Neighbor Interactions between Amino Acid Residues

Authors: Reinhard Schweitzer-Stenner, Bridget Milorey, Harald Schwalbe

Journal: Biomolecules

PubMed ID: 35625612

Doi: 10.3390/biom12050684

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Molecular mechanism of the wake-promoting agent TAK-925

Authors: Jie Yin, Yanyong Kang, Aaron P McGrath, Karen Chapman, Megan Sjodt, Eiji Kimura, Atsutoshi Okabe, Tatsuki Koike, Yuhei Miyanohana, Yuji Shimizu, Rameshu Rallabandi, Peng Lian, Xiaochen Bai, Mack Flinspach, Jef K De Brabander, Daniel M Rosenbaum

Journal: Nat Commun

PubMed ID: 35614071

Doi: 10.1038/s41467-022-30601-3

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Reduction of Influenza A Virus Transmission in Mice by a Universal Intranasal Vaccine Candidate is Long-Lasting and Does Not Require Antibodies

Authors: Graeme E Price, Chia-Yun Lo, Julia A Misplon, Suzanne L Epstein

Journal: J Virol

PubMed ID: 35638848

Doi: 10.1128/jvi.00320-22

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Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment

Authors: Yang Liu, Qiang Guo, Heng Yang, Xiao-Wen Zhang, Na Feng, Jing-Kang Wang, Ting-Ting Liu, Ke-Wu Zeng, Peng-Fei Tu

Journal: ACS Cent Sci

PubMed ID: 36032766

Doi: 10.1021/acscentsci.2c00107

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Optimization of the antimicrobial peptide Bac7 by deep mutational scanning

Authors: Philipp Koch, Steven Schmitt, Alexander Heynisch, Anja Gumpinger, Irene Wüthrich, Marina Gysin, Dimitri Shcherbakov, Sven N Hobbie, Sven Panke, Martin Held

Journal: BMC Biol

PubMed ID: 35578204

Doi: 10.1186/s12915-022-01304-4

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Immunogenicity, safety, and antiphospholipid antibodies after SARS-CoV-2 vaccine in patients with primary antiphospholipid syndrome

Authors: Flavio Signorelli, Gustavo Guimarães Moreira Balbi, Nadia E Aikawa, Clovis A Silva, Léonard de Vinci Kanda Kupa, Ana C Medeiros-Ribeiro, Emily Fn Yuki, Sandra G Pasoto, Carla Gs Saad, Eduardo F Borba, Luciana Parente Costa Seguro, Tatiana Pedrosa, Vitor Antonio de Angeli Oliveira, Ana Luisa Cerqueira de Sant'Ana Costa, Carolina T Ribeiro, Roseli Eliana Beseggio Santos, Danieli Castro Oliveira Andrade, Eloisa Bonfá

Journal: Lupus

PubMed ID: 35593174

Doi: 10.1177/09612033221102073

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Luteolin suppresses TNF-α-induced inflammatory injury and senescence of nucleus pulposus cells via the Sirt6/NF-κB pathway

Authors: Tian Xie, Jun Yuan, Ling Mei, Ping Li, Ruijie Pan

Journal: Exp Ther Med

PubMed ID: 35747154

Doi: 10.3892/etm.2022.11396

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Performance analysis among multiple fully automated anti-SARS-CoV-2 antibody measurement reagents: A potential indicator for the correlation of protection in the antibody titer

Authors: Ryo Kobayashi, Ema Suzuki, Ryosei Murai, Makito Tanaka, Yoshihiro Fujiya, Satoshi Takahashi

Journal: J Infect Chemother

PubMed ID: 35667939

Doi: 10.1016/j.jiac.2022.05.016

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Phosphorylation of HORMA-domain protein HTP-3 at Serine 285 is dispensable for crossover formation

Authors: Debabrata Das, Shalini Trivedi, Jitka Blazícková, Swathi Arur, Nicola Silva

Journal: G3 (Bethesda)

PubMed ID: 35389463

Doi: 10.1093/g3journal/jkac079

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Assessing the Activity of Antimicrobial Peptides Against Common Marine Bacteria Located in Rotifer (Brachionus plicatilis) Cultures

Authors: Chelsea Woods, Lindsey Woolley, Gavin Partridge, Mengqi Chen, Evan F Haney, Robert E W Hancock, Nicky Buller, Andrew Currie

Journal: Probiotics Antimicrob Proteins

PubMed ID: 35612776

Doi: 10.1007/s12602-022-09928-2

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Zika Virus Envelope Protein Domain III Produced in Has the Potential for Diagnostic Applications

Authors: John Willians Oliveira Prates, Mariana Fonseca Xisto, João Vitor da Silva Rodrigues, João Pedro Cruz Colombari, Júlia Maria Alves Meira, Roberto Sousa Dias, Cynthia Canedo da Silva, E Sérgio Oliveira de Paula

Journal: Diagnostics (Basel)

PubMed ID: 35626353

Doi: 10.3390/diagnostics12051198

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Insect cell expression and purification of recombinant SARS-COV-2 spike proteins that demonstrate ACE2 binding

Authors: Lucas R Struble, Audrey L Smith, William E Lutz, Gabrielle Grubbs, Satish Sagar, Kenneth W Bayles, Prakash Radhakrishnan, Surender Khurana, Dalia El-Gamal, Gloria E O Borgstahl

Journal: Protein Sci

PubMed ID: 35481636

Doi: 10.1002/pro.4300

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Rapid evolution and mechanism elucidation for efficient cellobiose-utilizing Saccharomyces cerevisiae through Synthetic Chromosome Rearrangement and Modification by LoxPsym-mediated Evolution

Authors: Yuwei Zhang, Zhaoxian Xu, Minrui Lu, Boning Ding, Sitong Chen, Zhiqiang Wen, Yang Yu, Linlin Zhou, Mingjie Jin

Journal: Bioresour Technol

PubMed ID: 35533888

Doi: 10.1016/j.biortech.2022.127268

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CARs-DB: A Database of Cryptic Amyloidogenic Regions in Intrinsically Disordered Proteins

Authors: Carlos Pintado-Grima, Oriol Bárcenas, Zoe Manglano-Artuñedo, Rita Vilaça, Sandra Macedo-Ribeiro, Irantzu Pallarès, Jaime Santos, Salvador Ventura

Journal: Front Mol Biosci

PubMed ID: 35898309

Doi: 10.3389/fmolb.2022.882160

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A vaccine targeting resistant tumours by dual T cell plus NK cell attack

Authors: Soumya Badrinath, Maxence O Dellacherie, Aileen Li, Shiwei Zheng, Xixi Zhang, Miguel Sobral, Jason W Pyrdol, Kathryn L Smith, Yuheng Lu, Sabrina Haag, Hamza Ijaz, Fawn Connor-Stroud, Tsuneyasu Kaisho, Glenn Dranoff, Guo-Cheng Yuan, David J Mooney, Kai W Wucherpfennig

Journal: Nature

PubMed ID: 35614223

Doi: 10.1038/s41586-022-04772-4

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Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis

Authors: Do Hoon Kwon, Feng Zhang, Justin G Fedor, Yang Suo, Seok-Yong Lee

Journal: Nat Commun

PubMed ID: 35610228

Doi: 10.1038/s41467-022-30602-2

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Plantaricin A, Derived from Lactiplantibacillus plantarum, Reduces the Intrinsic Resistance of Gram-Negative Bacteria to Hydrophobic Antibiotics

Authors: Fanqiang Meng, Yanan Liu, Ting Nie, Chao Tang, Fengxia Lyu, Xiaomei Bie, Yingjian Lu, Mingwen Zhao, Zhaoxin Lu

Journal: Appl Environ Microbiol

PubMed ID: 35499329

Doi: 10.1128/aem.00371-22

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Assessing four subdomain-specific affinity resins' capability to separate half-antibody from intact bispecific antibody

Authors: Wei Chen, Ting Zhang, Yan Wan, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 35661701

Doi: 10.1016/j.pep.2022.106124

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Rgs16 promotes antitumor CD8 T cell exhaustion

Authors: Nina Weisshaar, Jingxia Wu, Yanan Ming, Alaa Madi, Agnes Hotz-Wagenblatt, Sicong Ma, Alessa Mieg, Marvin Hering, Ferdinand Zettl, Kerstin Mohr, Tilo Schlimbach, Nora Ten Bosch, Franziska Hertel, Lisann Müller, Hannah Byren, Mona Wang, Helena Borgers, Mareike Munz, Lukas Schmitt, Franciscus van der Hoeven, Ulrich Kloz, Rafael Carretero, Nikolai Schleußner, Rene-Filip Jackstadt, Ilse Hofmann, Guoliang Cui

Journal: Sci Immunol

PubMed ID: 35622904

Doi: 10.1126/sciimmunol.abh1873

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Bioengineered miR-34a modulates mitochondrial inner membrane protein 17 like 2 (MPV17L2) expression toward the control of cancer cell mitochondrial functions

Authors: Wan-Rong Yi, Mei-Juan Tu, Ai-Xi Yu, Jun Lin, Ai-Ming Yu

Journal: Bioengineered

PubMed ID: 35579419

Doi: 10.1080/21655979.2022.2076399

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De Novo Arginine Synthesis Is Required for Full Virulence of pv During Walnut Bacterial Blight Disease

Authors: Cíntia H D Sagawa, Renata de A B Assis, Paulo A Zaini, Houston Saxe, Phillip A Wilmarth, Michelle Salemi, Brett S Phinney, Abhaya M Dandekar

Journal: Phytopathology

PubMed ID: 34941365

Doi: 10.1094/PHYTO-07-21-0302-R

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Green Tea Catechins, (-)-Catechin Gallate, and (-)-Gallocatechin Gallate are Potent Inhibitors of ABA-Induced Stomatal Closure

Authors: Kanane Sato, Shunya Saito, Kohsuke Endo, Masaru Kono, Taishin Kakei, Haruka Taketa, Megumi Kato, Shin Hamamoto, Matteo Grenzi, Alex Costa, Shintaro Munemasa, Yoshiyuki Murata, Yasuhiro Ishimaru, Nobuyuki Uozumi

Journal: Adv Sci (Weinh)

PubMed ID: 35524639

Doi: 10.1002/advs.202201403

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Enhancement of Farnesoid X Receptor Inhibits Migration, Adhesion and Angiogenesis through Proteasome Degradation and VEGF Reduction in Bladder Cancers

Authors: Chien-Rui Lai, Hisao-Hsien Wang, Hsin-Han Chang, Yu-Ling Tsai, Wen-Chiuan Tsai, Chen-Ray Lee, Chih-Ying Changchien, Yu-Chen Cheng, Sheng-Tang Wu, Ying Chen

Journal: Int J Mol Sci

PubMed ID: 35563650

Doi: 10.3390/ijms23095259

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Depolarizing Na and hyperpolarizing K channels are co-trafficked in sensory neurons

Authors: Grant P Higerd-Rusli, Matthew Alsaloum, Sidharth Tyagi, Nivedita Sarveswaran, Mark Estacion, Elizabeth J Akin, Fadia B Dib-Hajj, Shujun Liu, Daniel Sosniak, Peng Zhao, Sulayman D Dib-Hajj, Stephen G Waxman

Journal: J Neurosci

PubMed ID: 35589395

Doi: 10.1523/JNEUROSCI.0058-22.2022

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Engineered SH2 Domains for Targeted Phosphoproteomics

Authors: Gregory D Martyn, Gianluca Veggiani, Ulrike Kusebauch, Seamus R Morrone, Bradley P Yates, Alex U Singer, Jiefei Tong, Noah Manczyk, Gerald Gish, Zhi Sun, Igor Kurinov, Frank Sicheri, Michael F Moran, Robert L Moritz, Sachdev S Sidhu

Journal: ACS Chem Biol

PubMed ID: 35613471

Doi: 10.1021/acschembio.2c00051

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