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Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity-Making Mutations

Authors: Juan Luis Pacheco-Garcia, Dmitry S Loginov, Ernesto Anoz-Carbonell, Pavla Vankova, Rogelio Palomino-Morales, Eduardo Salido, Petr Man, Milagros Medina, Athi N Naganathan, Angel L Pey

Journal: Antioxidants (Basel)

PubMed ID: 35740007

Doi: 10.3390/antiox11061110

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Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in

Authors: Xiaolu Tai, Yaqun Zhang, Jindong Yao, Xuan Li, Jun Liu, Jiazhen Han, Jianjun Lyu, Gufa Lin, Chao Zhang

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35795143

Doi: 10.3389/fendo.2022.892407

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Deletion of COM donor and acceptor domains and the interaction between modules in bacillomycin D produced by

Authors: Ziyan Lv, Wenjie Ma, Ping Zhang, Zhaoxin Lu, Libang Zhou, Fanqiang Meng, Zuwei Wang, Xiaomei Bie

Journal: Synth Syst Biotechnol

PubMed ID: 35782484

Doi: 10.1016/j.synbio.2022.05.007

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Altered gut microbiota and metabolites profile are associated with reduced bone metabolism in ethanol-induced osteoporosis

Authors: Zhao Liu, Xilin Xu, Yiwei Shen, Yuanyuan Hao, Wenwen Cui, Wenyan Li, Xin Zhang, Hang Lv, Xiaodong Li, Yunlong Hou, Xiaofeng Zhang

Journal: Cell Prolif

PubMed ID: 35688648

Doi: 10.1111/cpr.13245

Products & Services: Proteins, Expression, Isolation and Analysis

Pre-existing immunity modulates responses to mRNA boosters

Authors: Tanushree Dangi, Sarah Sanchez, Min Han Lew, Lavanya Visvabharathy, Justin Richner, Igor J Koralnik, Pablo Penaloza-MacMaster

Journal: biorxiv

PubMed ID: 35794898

Doi: 10.1101/2022.06.27.497248

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mRNA Booster Vaccination Enhances Antibody Responses against SARS-CoV2 Omicron Variant in Individuals Primed with mRNA or Inactivated Virus Vaccines

Authors: Biyan Zhang, Jianxin Huo, Yuhan Huang, Shuan Yong Teo, Kaibo Duan, Yanfeng Li, Lim Kai Toh, Kong Peng Lam, Shengli Xu

Journal: Vaccines (Basel)

PubMed ID: 35891221

Doi: 10.3390/vaccines10071057

RNA Polymerase II Transcription in : TFIIB from Can Replace the Transcriptional Functions of Fission Yeast TFIIB In Vivo and In Vitro

Authors: Diego A Rojas, Fabiola Urbina, Aldo Solari, Edio Maldonado

Journal: Int J Mol Sci

PubMed ID: 35743306

Doi: 10.3390/ijms23126865

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Dynamic transcriptome profiling reveals essential roles of the receptor tyrosine kinases (RTK) family in feather development of duck

Authors: H Liu, Q Xu, Y Xi, S Ma, J Wang, L Bai, C Han, H He, L Li

Journal: Br Poult Sci

PubMed ID: 35383522

Doi: 10.1080/00071668.2022.2061839

Products & Services: Proteins, Expression, Isolation and Analysis

Immunological characteristics of MAV/06 strain of varicella-zoster virus vaccine in an animal model

Authors: Duckhyang Shin, Younchul Shin, Eunmi Kim, Hyojung Nam, Haiyan Nan, Jaewoo Lee

Journal: BMC Immunol

PubMed ID: 35658899

Doi: 10.1186/s12865-022-00503-6

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The optimal docking strength for reversibly tethered kinases

Authors: Mateusz Dyla, Nicolás S González Foutel, Daniel E Otzen, Magnus Kjaergaard

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35696590

Doi: 10.1073/pnas.2203098119

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Preclinical study of formulated recombinant nucleocapsid protein, the receptor binding domain of the spike protein, and truncated spike (S1) protein as vaccine candidates against COVID-19 in animal models

Authors: Shahram Nazarian, Gholamreza Olad, Raziyeh Abdolhamidi, Mohammad Javad Motamedi, Rouhollah Kazemi, Emad Kordbacheh, Alireza Felagari, Hanieh Olad, Ali Ahmadi, Alireza Bahiraee, Parisa Farahani, Leila Haghighi, Faezeh Hassani, Vahideh Hajhassan, Mona Nadi, Abdolkarim Sheikhi, Jafar Salimian, Jafar Amani

Journal: Mol Immunol

PubMed ID: 35802999

Doi: 10.1016/j.molimm.2022.06.007

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Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

Authors: Daniel A Michelson, Koji Hase, Tsuneyasu Kaisho, Christophe Benoist, Diane Mathis

Journal: Cell

PubMed ID: 35714609

Doi: 10.1016/j.cell.2022.05.018

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Novel Mutations Associated With Epilepsy and Impacts on Neuronal Excitability

Authors: Changning Xie, Fangyun Liu, Hailan He, Fang He, Leilei Mao, Xiaole Wang, Fei Yin, Jing Peng

Journal: Front Mol Neurosci

PubMed ID: 35845605

Doi: 10.3389/fnmol.2022.870182

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Betaine Alleviates High-Fat Diet-Induced Disruptionof Hepatic Lipid and Iron Homeostasis in Mice

Authors: Yanlin Li, Wenduo Jiang, Yue Feng, Lei Wu, Yimin Jia, Ruqian Zhao

Journal: Int J Mol Sci

PubMed ID: 35682942

Doi: 10.3390/ijms23116263

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Development of a universal antibiotic resistance screening reporter for improving efficiency of cytosine and adenine base editing

Authors: Lixia Ma, Jiani Xing, Qian Li, Zhiying Zhang, Kun Xu

Journal: J Biol Chem

PubMed ID: 35671823

Doi: 10.1016/j.jbc.2022.102103

Products & Services: Proteins, Expression, Isolation and Analysis

EXPLICIT-Kinase: A gene expression predictor for dissecting the functions of the Arabidopsis kinome

Authors: Yuming Peng, Wanzhu Zuo, Hui Zhou, Fenfen Miao, Yu Zhang, Yue Qin, Yi Liu, Yu Long, Shisong Ma

Journal: J Integr Plant Biol

PubMed ID: 35446465

Doi: 10.1111/jipb.13267

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Effect of Solvation Conditions on Inter- and Intramolecular Assembly of Full-Length TDP-43

Authors: Abhilasha A Doke, Santosh Kumar Jha

Journal: J Phys Chem B

PubMed ID: 35758053

Doi: 10.1021/acs.jpcb.2c02203

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CRISPR-Cas9 Expressed in Stably Transduced Cell Lines Promotes Recombination and Selects for Herpes Simplex Virus Recombinants

Authors: Hyung Suk Oh, Fernando M Diaz, Changhong Zhou, Nicholas Carpenter, David M Knipe

Journal: Curr Res Virol Sci

PubMed ID: 36330462

Doi: 10.1016/j.crviro.2022.100023

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In silico screening and heterologous expression of soluble dimethyl sulfide monooxygenases of microbial origin in Escherichia coli

Authors: Prasanth Karaiyan, Catherine Ching Han Chang, Eng-Seng Chan, Beng Ti Tey, Ramakrishnan Nagasundara Ramanan, Chien Wei Ooi

Journal: Appl Microbiol Biotechnol

PubMed ID: 35713659

Doi: 10.1007/s00253-022-12008-8

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Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family

Authors: Sivasankar Putta, Lucia Alvarez, Stephan Lüdtke, Peter Sehr, Gerd A Müller, Samantha M Fernandez, Sarvind Tripathi, Joe Lewis, Toby J Gibson, Lucia B Chemes, Seth M Rubin

Journal: Structure

PubMed ID: 35716663

Doi: 10.1016/j.str.2022.05.019

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Independent pathways control muscle tissue size and sarcomere remodeling

Authors: David Brooks, Simranjot Bawa, Alexandria Bontrager, Marta Stetsiv, Yungui Guo, Erika R Geisbrecht

Journal: Dev Biol

PubMed ID: 35760368

Doi: 10.1016/j.ydbio.2022.06.014

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Ultrasensitive fluorometric oligonucleotide immunoassay for the simultaneous and efficient detection of two mycotoxins in agricultural products

Authors: Ming Li, Chenfei Han, Chuqin Yang, Mingna Sun, Jinsheng Duan, Xuchun Qiu, Daolin Du

Journal: Anal Methods

PubMed ID: 35583257

Doi: 10.1039/d2ay00367h

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An in-library ligation strategy and its application in CRISPR/Cas9 screening of high-order gRNA combinations

Authors: Zhike Lu, Ke Ni, Yingying Wang, Yangfan Zhou, Yini Li, Jianfeng Yan, Qingkai Song, Min Liu, Yujun Xu, Zhenxing Yu, Tiannan Guo and Lijia Ma

Journal: Nucleic Acids Res

PubMed ID: 35670669

Doi: 10.1093/nar/gkac458

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Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376

Authors: Xiao-dong Luan, Bin-xian Chen, Wei-juan Shang , Wan-chao Yin , Ye Jin , Lei-ke Zhang , H. Eric Xu and Shu-yang Zhang

Journal: Acta pharmacologica Sinica

Doi: 10.1038/s41401-022-00929-z

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Engineering substrate specificity of HAD phosphatases and multienzyme systems development for the thermodynamic-driven manufacturing sugars

Authors: Chaoyu Tian , Jiangang Yang , Cui Liu , Peng Chen , Tong Zhang , Yan Men , Hongwu Ma , Yuanxia Sun, Yanhe Ma

Journal: Nat Commun

PubMed ID: 35739124

Doi: doi.org/10.1038/s41467-022-31371-8

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WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage

Authors: Seong-Su Han , Kuo-Kuang Wen , María L García-Rubio , Marc S Wold , Andrés Aguilera , Wojciech Niedzwiedz , Yatin M Vyas

Journal: Nat Commun

PubMed ID: 35768435

Doi: 10.1038/s41467-022-31415-z.

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Rnd3 Expression is Necessary to Maintain Mitochondrial Homeostasis but Dispensable for Autophagy

Authors: Cristina Cueto-Ureña, Enric Mocholí, Josep Escrivá-Fernández, Susana González-Granero, Sabina Sánchez-Hernández, Amalia Solana-Orts, Begoña Ballester-Lurbe, Karim Benabdellah, Rosa M Guasch, José Manuel García-Verdugo, Francisco Martín, Paul J Coffer, Ignacio Pérez-Roger, Enric Poch

Journal: Front Cell Dev Biol

PubMed ID: 35832788

Doi: 10.3389/fcell.2022.834561

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The humoral immune response more than one year after SARS-CoV-2 infection: low detection rate of anti-nucleocapsid antibodies via Euroimmun ELISA

Authors: Gregor Paul, Philipp Strnad, Oliver Wienand, Ursula Krause, Thomas Plecko, Anja Effenberger-Klein, Katrin Elisabeth Giel, Florian Junne, Annette Galante-Gottschalk, Stefan Ehehalt, Jan Steffen Jürgensen

Journal: Infection

PubMed ID: 35648370

Doi: 10.1007/s15010-022-01830-x

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Bioinformatics-Driven Identification of p62 as A Crucial Oncogene in Liver Cancer

Authors: Ling Wang, Culton R Hensley, Mary E Howell, Shunbin Ning

Journal: Front Oncol

PubMed ID: 35814476

Doi: 10.3389/fonc.2022.923009

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Assembly checkpoint of the proteasome regulatory particle is activated by coordinated actions of proteasomal ATPase chaperones

Authors: Asrafun Nahar, Vladyslava Sokolova, Suganya Sekaran, James D Orth, Soyeon Park

Journal: Cell Reports

PubMed ID: 35675778

Doi: 10.1016/j.celrep.2022.110918

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A Nanopore-Based Saccharide Sensor

Authors: Shanyu Zhang, Zhenyuan Cao, Pingping Fan, Yuqin Wang, Wendong Jia, Liying Wang, Kefan Wang, Yao Liu, Xiaoyu Du, Chengzhen Hu, Panke Zhang, Hong-Yuan Chen, Shuo Huang

Journal: Angew Chem Int Ed Engl

PubMed ID: 35718742

Doi: 10.1002/anie.202203769

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Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis

Authors: Dezheng Zhou, Zhenshu Li, Yue Sun, Jing Yan, Guowei Huang and Wen Li

Journal: Int. J. Mol. Sci

Doi: doi.org/10.3390/ijms23136948

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Thymosin β4 increases cardiac cell proliferation, cell engraftment, and the reparative potency of human induced-pluripotent stem cell-derived cardiomyocytes in a porcine model of acute myocardial infarction

Authors: Shi Hua Tan , Sze Jie Loo , Yu Gao , Zhong Hao Tao , Li Ping Su , Chen Xu Wang , Sophia L Zhang , Yong Hui Mu , Ying Hua Cui , Desiree Abdurrachim , Wei Hsin Wang , Janise Lalic , Kheng Choon Lim , Jun Bu , Ru San Tan , Teck Hock Lee , Jianyi Zhang , Lei Ye

Journal: Theranostics

PubMed ID: 34335970

Doi: 10.7150/thno.56757

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Missense mutations affecting Ca-coordination in GCAP1 lead to cone-rod dystrophies by altering protein structural and functional properties

Authors: Giuditta Dal Cortivo, Valerio Marino, Francesco Bonì, Mario Milani, Daniele Dell'Orco

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 32650103

Doi: 10.1016/j.bbamcr.2020.118794

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Screening membraneless organelle participants with machine-learning models that integrate multimodal features

Authors: Zhaoming Chen, Chao Hou, Liang Wang, Chunyu Yu, Taoyu Chen, Boyan Shen, Yaoyao Hou, Pilong Li, Tingting Li

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35687670

Doi: 10.1073/pnas.2115369119

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Codon Optimization Using a Recurrent Neural Network

Authors: Dennis R Goulet, Yongqi Yan, Palak Agrawal, Andrew B Waight, Amanda Nga-Sze Mak, Yi Zhu

Journal: J Comput Biol

PubMed ID: 35727687

Doi: 10.1089/cmb.2021.0458

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Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition

Authors: Eric T Baldwin, Matthias Götte, Egor P Tchesnokov, Eddy Arnold, Margit Hagel, Charles Nichols, Pam Dossang, Marieke Lamers, Paul Wan, Stefan Steinbacher, Donna L Romero

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35771941

Doi: 10.1073/pnas.2200260119

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Comparison of the Immunogenic Properties of Carrying the Mycobacterial Ag85B-ESAT-6 Antigen at Various Cellular Localizations

Authors: Kamilla Wiull, Preben Boysen, Katarzyna Kuczkowska, Lars Fredrik Moen, Harald Carlsen, Vincent G H Eijsink, Geir Mathiesen

Journal: Front Microbiol

PubMed ID: 35722346

Doi: 10.3389/fmicb.2022.900922

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Targeting the interaction of GABA receptors with CaMKII with an interfering peptide restores receptor expression after cerebral ischemia and inhibits progressive neuronal death in mouse brain cells and slices

Authors: Karthik Balakrishnan, Mohammad Hleihil, Musadiq A Bhat, Robert P Ganley, Markus Vaas, Jan Klohs, Hanns Ulrich Zeilhofer, Dietmar Benke

Journal: Brain Pathol

PubMed ID: 35698024

Doi: 10.1111/bpa.13099

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MRCKα is a novel regulator of prolactin-induced lactogenesis in bovine mammary epithelial cells

Authors: Fang Wang, Jürgen van Baal, Lu Ma, Xuejun Gao, Jan Dijkstra, Dengpan Bu

Journal: Anim Nutr

PubMed ID: 35891685

Doi: 10.1016/j.aninu.2022.06.001

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Structural and mechanistic insights into the inhibition of type I-F CRISPR-Cas system by anti-CRISPR protein AcrIF23

Authors: Junhui Ren, Hao Wang, Lingguang Yang, Feixue Li, Yao Wu, Zhipu Luo, Zeliang Chen, Yi Zhang, Yue Feng

Journal: J Biol Chem

PubMed ID: 35697070

Doi: 10.1016/j.jbc.2022.102124

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Immunoinformatics Aided Design and Validation of a Cross-Reactive Peptide Based Multi-Epitope Vaccine Targeting Multiple Serotypes of Dengue Virus

Authors: Vikas Kaushik, Sunil Krishnan G, Lovi Raj Gupta, Utkarsh Kalra, Abdul Rajjak Shaikh, Luigi Cavallo, Mohit Chawla

Journal: Front Immunol

PubMed ID: 35799781

Doi: 10.3389/fimmu.2022.865180

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Recombinant Carrying Endostatin Protein Alleviates Dextran Sodium Sulfate-Induced Colitis and Colon Cancer in Rats

Authors: Zhiqian Bi, Enqing Cui, Yingying Yao, Xiaoyao Chang, Xiaoyang Wang, Yuhui Zhang, Gen-Xing Xu, Hongqin Zhuang, Zi-Chun Hua

Journal: Front Microbiol

PubMed ID: 35847065

Doi: 10.3389/fmicb.2022.927277

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CRISPR/CasRx-Mediated RNA Knockdown Reveals That ACE2 Is Involved in the Regulation of Oligodendroglial Cell Morphological Differentiation

Authors: Yukino Kato, Kenji Tago, Shoya Fukatsu, Miyu Okabe, Remina Shirai, Hiroaki Oizumi, Katsuya Ohbuchi, Masahiro Yamamoto, Kazushige Mizoguchi, Yuki Miyamoto, Junji Yamauchi

Journal: Noncoding RNA

PubMed ID: 35736639

Doi: 10.3390/ncrna8030042

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Lipases secreted by a gut bacterium inhibit arbovirus transmission in mosquitoes

Authors: Xi Yu, Liangqin Tong, Liming Zhang, Yun Yang, Xiaoping Xiao, Yibin Zhu, Penghua Wang, Gong Cheng

Journal: PLoS Pathog

PubMed ID: 35679229

Doi: 10.1371/journal.ppat.1010552

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PBP1 plays key roles in sex pheromone reception of the fall armyworm

Authors: Yongzhi Zhong, Minghui Xie, Zhongjuan Di, Fengqi Li, Jiaqi Chen, Xiangxin Kong, Lulu Lin, Weihua Su, Lina Xu, Feng Zhang, Rui Tang, Haoliang Chen

Journal: Int J Biol Macromol

PubMed ID: 35709868

Doi: 10.1016/j.ijbiomac.2022.06.068

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Characterization, expression and function of the pyrokinins (PKs) in the giant freshwater prawn, Macrobrachium rosenbergii

Authors: Tipsuda Thongbuakaew, Sirirak Mukem, Arada Chaiyamoon, Kanjana Khornchatri, Thanapong Kruangkum, Scott F Cummins, Prasert Sobhon

Journal: J Exp Biol

PubMed ID: 35578905

Doi: 10.1242/jeb.243742

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Expression optimization, purification, and biophysical characterization of a GluN2D-containing NMDA receptor

Authors: Aram Chang, Justin M Liu, Katrina Nguyen, P Rajesh Kumar

Journal: Protein Expr Purif

PubMed ID: 35752385

Doi: 10.1016/j.pep.2022.106129

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Inactivated whole-virion vaccine BBV152/Covaxin elicits robust cellular immune memory to SARS-CoV-2 and variants of concern

Authors: Rajesh Vikkurthi, Asgar Ansari, Anupama R Pai, Someshwar Nath Jha, Shilpa Sachan, Suvechchha Pandit, Bhushan Nikam, Anurag Kalia, Bimal Prasad Jit, Hilal Ahmad Parray, Savita Singh, Pallavi Kshetrapal, Nitya Wadhwa, Tripti Shrivastava, Poonam Coshic, Suresh Kumar, Pragya Sharma, Nandini Sharma, Juhi Taneja, Anil K Pandey, Ashok Sharma, Ramachandran Thiruvengadam, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Shinjini Bhatnagar, Nimesh Gupta

Journal: Nat Microbiol

PubMed ID: 35681012

Doi: 10.1038/s41564-022-01161-5

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Long Intergenic Noncoding RNA MIAT as a Regulator of Human Th17 Cell Differentiation

Authors: Mohd Moin Khan, Meraj Hasan Khan, Ubaid Ullah Kalim, Sofia Khan, Sini Junttila, Niklas Paulin, Lingjia Kong, Omid Rasool, Laura L Elo, Riitta Lahesmaa

Journal: Front Immunol

PubMed ID: 35784351

Doi: 10.3389/fimmu.2022.856762

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Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT

Authors: Xuefang Pan, Mahsa Taherzadeh, Poulomee Bose, Rachel Heon-Roberts, Annie L A Nguyen, TianMeng Xu, Camila Pará, Yojiro Yamanaka, David A Priestman, Frances M Platt, Shaukat Khan, Nidhi Fnu, Shunji Tomatsu, Carlos R Morales, Alexey V Pshezhetsky

Journal: J Exp Med

PubMed ID: 35704026

Doi: 10.1084/jem.20211860

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Increasing the resilience of plant immunity to a warming climate

Authors: Jong Hum Kim, Christian Danve M Castroverde, Shuai Huang, Chao Li, Richard Hilleary, Adam Seroka, Reza Sohrabi, Diana Medina-Yerena, Bethany Huot, Jie Wang, Kinya Nomura, Sharon K Marr, Mary C Wildermuth, Tao Chen, John D MacMicking, Sheng Yang He

Journal: Nature

PubMed ID: 35768511

Doi: 10.1038/s41586-022-04902-y

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TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules

Authors: Andrew C McShan, Christine A Devlin, Georgia F Papadaki, Yi Sun, Adam I Green, Giora I Morozov, George M Burslem, Erik Procko, Nikolaos G Sgourakis

Journal: Nat Chem Biol

PubMed ID: 35725941

Doi: 10.1038/s41589-022-01049-9

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Biosynthetic potential of the global ocean microbiome

Authors: Lucas Paoli, Hans-Joachim Ruscheweyh, Clarissa C Forneris, Florian Hubrich, Satria Kautsar, Agneya Bhushan, Alessandro Lotti, Quentin Clayssen, Guillem Salazar, Alessio Milanese, Charlotte I Carlström, Chrysa Papadopoulou, Daniel Gehrig, Mikhail Karasikov, Harun Mustafa, Martin Larralde, Laura M Carroll, Pablo Sánchez, Ahmed A Zayed, Dylan R Cronin, Silvia G Acinas, Peer Bork, Chris Bowler, Tom O Delmont, Josep M Gasol, Alvar D Gossert, André Kahles, Matthew B Sullivan, Patrick Wincker, Georg Zeller, Serina L Robinson, Jörn Piel, Shinichi Sunagawa

Journal: Nature

PubMed ID: 35732736

Doi: 10.1038/s41586-022-04862-3

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Detection of the SARS-CoV-2 D614G Mutation Using VirSNiP SARS-CoV-2 Spike D614G Assay

Authors: Chih-Chieh Chen, Tze-Kiong Er

Journal: Clin Lab

PubMed ID: 35704738

Doi: 10.7754/Clin.Lab.2021.211009

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Development and Evaluation of Rapid and Accurate CRISPR/Cas13-Based RNA Diagnostics for Pneumonia

Authors: Yangqing Zhan, Xiaoqing Gao, Shaoqiang Li, Yeqi Si, Yuanxiang Li, Xu Han, Wenjun Sun, Zhengtu Li, Feng Ye

Journal: Front Cell Infect Microbiol

PubMed ID: 35782118

Doi: 10.3389/fcimb.2022.904485

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Identification and Characterization of an RRM-Containing, RNA Binding Protein in

Authors: Caterina Ciani, Anna Pérez-Ràfols, Isabelle Bonomo, Mariachiara Micaelli, Alfonso Esposito, Chiara Zucal, Romina Belli, Vito Giuseppe D'Agostino, Irene Bianconi, Vito Calderone, Linda Cerofolini, Orietta Massidda, Michael Bernard Whalen, Marco Fragai, Alessandro Provenzani

Journal: Biomolecules

PubMed ID: 35883478

Doi: 10.3390/biom12070922

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Immunogenicity of candidate SARS-CoV-2 DNA vaccines based on the spike protein

Authors: Heeji Lim, Se Eun Kim, Yun Ha Lee, Yun-Ho Hwang, Su Hwan Kim, Mi Young Kim, Gyung Tae Chung, You-Jin Kim, Dokeun Kim, Jung-Ah Lee

Journal: Virology

PubMed ID: 35751974

Doi: 10.1016/j.virol.2022.06.006

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Anti-spike protein antibody responses to BNT162b2 mRNA vaccine: A single-center survey in a COVID-19 non-epidemic area in Japan

Authors: Sho Mokuda, Namiki Kawanishi, Shintaro Kuroshima, Junko Kono, Hirofumi Nakayama, Hiroshi Mieno, Masashi Kawamoto

Journal: Vaccine X

PubMed ID: 35692460

Doi: 10.1016/j.jvacx.2022.100173

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Tip60 acetylation of histone H3K4 temporally controls chromosome passenger complex localization

Authors: Ewa Niedzialkowska, Limin Liu, Cem Kuscu, Zachary Mayo, Wladek Minor, Brian D Strahl, Mazhar Adli, P Todd Stukenberg

Journal: Mol Biol Cell

PubMed ID: 35653296

Doi: 10.1091/mbc.E21-06-0283

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Rapid titration of recombinant baculoviruses based on NanoLuc secretion in early infection

Authors: Jige Li, Meng Xu, Juan Sun, Junjun Li, Jianqing Chen, Qin Chen, Jian Chen

Journal: J Virol Methods

PubMed ID: 35728698

Doi: 10.1016/j.jviromet.2022.114565

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Role of PIM2 in acute lung injury induced by sepsis

Authors: Juncai Ding, Xiufang Yang, Huijuan Huang, Bo Wang

Journal: Exp Ther Med

PubMed ID: 35978927

Doi: 10.3892/etm.2022.11480

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ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia

Authors: Linjiang Lao, Isabelle Bourdeau, Lucia Gagliardi, Xiao He, Wei Shi, Bingbing Hao, Minjia Tan, Yan Hu, Junzheng Peng, Benoit Coulombe, David J Torpy, Hamish S Scott, Andre Lacroix, Hongyu Luo, Jiangping Wu

Journal: Nucleic Acids Res

PubMed ID: 35687106

Doi: 10.1093/nar/gkac483

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A structural vaccinology approach for in silico designing of a potential self-assembled nanovaccine against Leishmania infantum

Authors: Bahareh Vakili, Navid Nezafat, Manica Negahdaripour, Younes Ghasemi

Journal: Exp Parasitol

PubMed ID: 35709889

Doi: 10.1016/j.exppara.2022.108295

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Cross-Reactivity of IgG Antibodies and Virus Neutralization in mRNA-Vaccinated People Against Wild-Type SARS-CoV-2 and the Five Most Common SARS-CoV-2 Variants of Concern

Authors: Mandy Schwarze, Andor Krizsan, Alexandra Brakel, Fabian Pohl, Daniela Volke, Ralf Hoffmann

Journal: Front Immunol

PubMed ID: 35784285

Doi: 10.3389/fimmu.2022.915034

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bFGF-Loaded Mesoporous Silica Nanoparticles Promote Bone Regeneration Through the Wnt/β-Catenin Signalling Pathway

Authors: Mingkui Shen, Lulu Wang, Li Feng, Yi Gao, Sijing Li, Yulan Wu, Chuangye Xu, Guoxian Pei

Journal: Int J Nanomedicine

PubMed ID: 35698561

Doi: 10.2147/IJN.S366926

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Potentiating adoptive cell therapy using synthetic IL-9 receptors

Authors: Anusha Kalbasi, Mikko Siurala, Leon L Su, Mito Tariveranmoshabad, Lora K Picton, Pranali Ravikumar, Peng Li, Jian-Xin Lin, Helena Escuin-Ordinas, Tong Da, Sarah V Kremer, Amy L Sun, Sofia Castelli, Sangya Agarwal, John Scholler, Decheng Song, Philipp C Rommel, Enrico Radaelli, Regina M Young, Warren J Leonard, Antoni Ribas, Carl H June, K Christopher Garcia

Journal: Nature

PubMed ID: 35676488

Doi: 10.1038/s41586-022-04801-2

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Construction and Characterization of T7 Bacteriophages Harboring Apidaecin-Derived Sequences

Authors: Tobias Ludwig, Ralf Hoffmann, Andor Krizsan

Journal: Curr Issues Mol Biol

PubMed ID: 35735615

Doi: 10.3390/cimb44060174

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Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents

Authors: Jaime S Rosa Duque, Xiwei Wang, Daniel Leung, Samuel M S Cheng, Carolyn A Cohen, Xiaofeng Mu, Asmaa Hachim, Yanmei Zhang, Sau Man Chan, Sara Chaothai, Kelvin K H Kwan, Karl C K Chan, John K C Li, Leo L H Luk, Leo C H Tsang, Wilfred H S Wong, Cheuk Hei Cheang, Timothy K Hung, Jennifer H Y Lam, Gilbert T Chua, Winnie W Y Tso, Patrick Ip, Masashi Mori, Niloufar Kavian, Wing Hang Leung, Sophie Valkenburg, Malik Peiris, Wenwei Tu, Yu Lung Lau

Journal: Nat Commun

PubMed ID: 35764637

Doi: 10.1038/s41467-022-31485-z

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PD-1 and ICOS coexpression identifies tumor-reactive CD4+ T cells in human solid tumors

Authors: Rebekka Duhen, Olivier Fesneau, Kimberly A Samson, Alexandra K Frye, Michael Beymer, Venkatesh Rajamanickam, David Ross, Eric Tran, Brady Bernard, Andrew D Weinberg, Thomas Duhen

Journal: J Clin Invest

PubMed ID: 35439168

Doi: 10.1172/JCI156821

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The DUX4 protein is a co-repressor of the progesterone and glucocorticoid nuclear receptors

Authors: Julieta Quintero, Nizar Y Saad, Sabrina M Pagnoni, Daniela K Jacquelin, Laura V Gatica, Scott Q Harper, Alberto L Rosa

Journal: FEBS Lett

PubMed ID: 35662006

Doi: 10.1002/1873-3468.14416

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Kinetics of immune responses to SARS-CoV-2 proteins in individuals with varying severity of infection and following a single dose of the AZD1222

Authors: Deshni Jayathilaka, Chandima Jeewandara, Laksiri Gomes, Tibutius Thanesh Pramanayagam Jayadas, Achala Kamaladasa, Gayasha Somathilake, Dinuka Guruge, Pradeep Darshana Pushpakumara, Thushali Ranasinghe, Inoka Sepali Aberathna, Saubhagya Danasekara, Buddini Gunathilaka, Heshan Kuruppu, Ananda Wijewickrama, Ruwan Wijayamuni, Lisa Schimanski, T K Tan, Graham S Ogg, Alain Townsend, Gathsaurie Neelika Malavige

Journal: Clin Exp Immunol

PubMed ID: 35641142

Doi: 10.1093/cei/uxac009

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Tailored protein-conjugated DNA nanoplatform for synergistic cancer therapy

Authors: Dingkang Liu, Ye Chen, Qun Wang, Yue Ji, Lichen Bao, Wenbing Yao, Xiangdong Gao, Jun Yin

Journal: Journal of controlled release

PubMed ID: 35452765

Doi: 10.1016/j.jconrel.2022.04.022

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LncRNA LEMD1-AS1 relieves chondrocyte inflammation by targeting miR-944/PGAP1 in osteoarthritis

Authors: Haitao Li, Kaihua Lian, Jianguang Mao, Fuguo Huang, Chunli Zhang, Jianguo Zang

Journal: Cell Cycle

PubMed ID: 35686740

Doi: 10.1080/15384101.2022.2084294

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Phosphorylation of serine residues S252, S268/S269, and S879 in p120 catenin activates migration of presomitic mesoderm in gastrulating zebrafish embryos

Authors: Ariana Kupai, Hiroko Nakahara, Kathleen M Voss, Matthew S Hirano, Alexis Rodriguez, Donna L Lackey, James F Murayama, Chase J Mathieson, Botao Shan, Emma C Horton, Grace H Curtis, Joyce Huang, Merrill B Hille

Journal: Dev Dyn

PubMed ID: 35706088

Doi: 10.1002/dvdy.508

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Structures and mechanism of the plant PIN-FORMED auxin transporter

Authors: Kien Lam Ung, Mikael Winkler, Lukas Schulz, Martina Kolb, Dorina P Janacek, Emil Dedic, David L Stokes, Ulrich Z Hammes, Bjørn Panyella Pedersen

Journal: Nature

PubMed ID: 35768502

Doi: 10.1038/s41586-022-04883-y

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HA and M2 sequences alter the replication of 2013-16 H1 live attenuated influenza vaccine infection in human nasal epithelial cell cultures

Authors: Laura M Canaday, Jessica D Resnick, Hsuan Liu, Harrison Powell, Alyssa M McCoy, Dat Nguyen, Andrew Pekosz

Journal: Vaccine

PubMed ID: 35718589

Doi: 10.1016/j.vaccine.2022.05.088

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ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

Authors: William Hancock-Cerutti, Zheng Wu, Peng Xu, Narayana Yadavalli, Marianna Leonzino, Arun Kumar Tharkeshwar, Shawn M Ferguson, Gerald S Shadel, Pietro De Camilli

Journal: J Cell Biol

PubMed ID: 35657605

Doi: 10.1083/jcb.202106046

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De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts

Authors: Yameng Xu, Xinglong Wang, Chenyang Zhang, Xuan Zhou, Xianhao Xu, Luyao Han, Xueqin Lv, Yanfeng Liu, Song Liu, Jianghua Li, Guocheng Du, Jian Chen, Rodrigo Ledesma-Amaro, Long Liu

Journal: Nat Commun

PubMed ID: 35650215

Doi: 10.1038/s41467-022-30826-2

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Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast

Authors: Tengfei Liu , Yuanwei Gou , Bei Zhang , Rui Gao , Chang Dong , Mingming Qi , Lihong Jiang , Xuanwei Ding , Chun Li , Jiazhang Lian

Journal: Biotechnol Bioeng

PubMed ID: 35060115

Doi: doi.org/10.1002/bit.28040

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Using large-scale multi-module NRPS to heterologously prepare highly efficient lipopeptide biosurfactants in recombinant Escherichia coli

Authors: Ting Zhang , Qiang Zhou

Journal: Enzyme Microb Technol

PubMed ID: 35660853

Doi: doi.org/10.1016/j.enzmictec.2022.110068

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Gold Glyconanoparticles Combined with 91-99 Peptide of the Bacterial Toxin, Listeriolysin O, Are Efficient Immunotherapies in Experimental Bladder Tumors

Authors: Hector Terán-Navarro, Andrea Zeoli, David Salines-Cuevas, Marco Marradi, Noemi Montoya, Elena Gonzalez-Lopez, Javier Gonzalo Ocejo-Vinyals, Mario Dominguez-Esteban, Jose Luis Gutierrez-Baños, Felix Campos-Juanatey, Sonsoles Yañez-Diaz, Almudena Garcia-Castaño, Fernando Rivera, Ignacio Duran, Carmen Alvarez-Dominguez

Journal: Cancers (Basel)

PubMed ID: 35626016

Doi: 10.3390/cancers14102413

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A Novel Small RNA, DsrO, in Deinococcus radiodurans Promotes Methionine Sulfoxide Reductase () Expression for Oxidative Stress Adaptation

Authors: Yun Chen, Mingming Zhao, Mengli Lv, Min Lin, Jin Wang, Kaijing Zuo

Journal: Appl Environ Microbiol

PubMed ID: 35575549

Doi: 10.1128/aem.00038-22

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AntiV-SGN: a universal antiviral strategy to combat both RNA and DNA viruses by destroying their nucleic acids without sequence limitation

Authors: Kun Tian, Zhen Qi, Ying Chi, Huanran Qiang, Pei Wang, Yu Liu, Guohua Zhou, Fengcai Zhu, Qinglong Guo, Shu Xu

Journal: Microb Biotechnol

PubMed ID: 35611874

Doi: 10.1111/1751-7915.14076

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Selenium in Proteins: Conformational Changes Induced by Se Substitution on Methionine, as Studied in Isolated Model Peptides by Optical Spectroscopy and Quantum Chemistry

Authors: Gildas Goldsztejn, Venkateswara Rao Mundlapati, Valérie Brenner, Eric Gloaguen, Michel Mons

Journal: Molecules

PubMed ID: 35630640

Doi: 10.3390/molecules27103163

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Potent and pan-neutralization of SARS-CoV-2 variants of concern by DARPins

Authors: Vikas Chonira, Young Do Kwon, Jason Gorman, James Brett Case, Zhiqiang Ku, Rudo Simeon, Ryan G Casner, Darcy R Harris, Adam S Olia, Tyler Stephens, Lawrence Shapiro, Hannah Boyd, Yaroslav Tsybovsky, Florian Krammer, Michael S Diamond, Peter D Kwong, Zhiqiang An, Zhilei Chen

Journal: biorxiv

PubMed ID: 35677079

Doi: 10.1101/2022.05.30.493765

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Developing G value as an indicator for assessing the molecular status of immobilized antibody

Authors: Dongdong Gao, Fang Cheng, Xinglong Wang, Heqing Yang, Chong Liu, Chunmei Li, Eva Murong Yang, Gang Cheng, Wei He

Journal: Colloids Surf B Biointerfaces

PubMed ID: 35665639

Doi: 10.1016/j.colsurfb.2022.112593

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New insights into the mechanism of iron transport through the bacterial Ftr system present in pathogens

Authors: Anne Soisig Steunou, Armelle Vigouroux, Magali Aumont-Nicaise, Stéphane Plancqueel, Alain Boussac, Soufian Ouchane, Solange Moréra

Journal: FEBS J

PubMed ID: 35527501

Doi: 10.1111/febs.16476

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α-Synuclein Impacts on Intrinsic Neuronal Network Activity Through Reduced Levels of Cyclic AMP and Diminished Numbers of Active Presynaptic Terminals

Authors: Kristian Leite, Pretty Garg, F Paul Spitzner, Sofia Guerin Darvas, Mathias Bähr, Viola Priesemann, Sebastian Kügler

Journal: Front Mol Neurosci

PubMed ID: 35721317

Doi: 10.3389/fnmol.2022.868790

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Rapid, sensitive, and low-cost detection of Escherichia coli bacteria in contaminated water samples using a phage-based assay

Authors: Luis F Alonzo, Paras Jain, Troy Hinkley, Nick Clute-Reinig, Spencer Garing, Ethan Spencer, Van T T Dinh, David Bell, Sam Nugen, Kevin P Nichols, Anne-Laure M Le Ny

Journal: Sci Rep

PubMed ID: 35562180

Doi: 10.1038/s41598-022-11468-2

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An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

Authors: Lihong Liu, Sho Iketani, Yicheng Guo, Eswar R Reddem, Ryan G Casner, Manoj S Nair, Jian Yu, Jasper F-W Chan, Maple Wang, Gabriele Cerutti, Zhiteng Li, Nicholas C Morano, Candace D Castagna, Laura Corredor, Hin Chu, Shuofeng Yuan, Vincent Kwok-Man Poon, Chris Chun-Sing Chan, Zhiwei Chen, Yang Luo, Marcus Cunningham, Alejandro Chavez, Michael T Yin, David S Perlin, Moriya Tsuji, Kwok-Yung Yuen, Peter D Kwong, Zizhang Sheng, Yaoxing Huang, Lawrence Shapiro, David D Ho

Journal: Sci Transl Med

PubMed ID: 35438546

Doi: 10.1126/scitranslmed.abn6859

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Type B CTD Proteins Secreted by the Type IX Secretion System Associate with PorP-like Proteins for Cell Surface Anchorage

Authors: Dhana G Gorasia, Christine A Seers, Jacqueline E Heath, Michelle D Glew, Hamid Soleimaninejad, Catherine A Butler, Mark J McBride, Paul D Veith, Eric C Reynolds

Journal: Int J Mol Sci

PubMed ID: 35628493

Doi: 10.3390/ijms23105681

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Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens

Authors: Uddipan Kar, Sara Khaleeq, Priyanka Garg, Madhuraj Bhat, Poorvi Reddy, Venkada Subramanian Vignesh, Aditya Upadhyaya, Mili Das, Ghadiyaram Chakshusmathi, Suman Pandey, Somnath Dutta, Raghavan Varadarajan

Journal: Front Immunol

PubMed ID: 35720346

Doi: 10.3389/fimmu.2022.890622

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Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2

Authors: Juliana C Ferreira, Samar Fadl, Wael M Rabeh

Journal: J Biol Chem

PubMed ID: 35568197

Doi: 10.1016/j.jbc.2022.102023

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Transiently Transfected Mammalian Cell Cultures: An Adaptable and Effective Platform for Virus-like Particle-Based Vaccines against Foot-and-Mouth Disease Virus

Authors: Michael Puckette, Victoria Primavera, Erica Martel, Jose Barrera, William Hurtle, Benjamin Clark, Barbara Kamicker, Mariceny Zurita, David Brake, John Neilan

Journal: Viruses

PubMed ID: 35632734

Doi: 10.3390/v14050989

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Comparison of Four Systems for SARS-CoV-2 Antibody at Three Time Points after SARS-CoV-2 Vaccination

Authors: Jong Do Seo, Minjeong Nam, Tae Hwan Lee, Yeon-Sun Ahn, Seon-Hyeon Shin, Hye Young Han, Hee-Won Moon

Journal: Diagnostics (Basel)

PubMed ID: 35741159

Doi: 10.3390/diagnostics12061349

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Designing a novel E2-IFN-γ fusion protein against CSFV by immunoinformatics and structural vaccinology approaches

Authors: Yanmin Zhang, Weijian Zhang, Jun Cheng, Xuping Liu, Shiwei Miao, Wen-Song Tan, Liang Zhao

Journal: Appl Microbiol Biotechnol

PubMed ID: 35524776

Doi: 10.1007/s00253-022-11919-w

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AbSE Workflow: Rapid Identification of the Coding Sequence and Linear Epitope of the Monoclonal Antibody at the Single-cell Level

Authors: Lerong Ma, HongSheng Ouyang, Ang Su, Yuanzhu Zhang, Daxin Pang, Tao Zhang, Ruize Sun, Wentao Wang, Zicong Xie, Dongmei Lv

Journal: ACS Synth Biol

PubMed ID: 35503752

Doi: 10.1021/acssynbio.2c00018

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Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD

Authors: Tim Krischuns, Catherine Isel, Petra Drncova, Maria Lukarska, Alexander Pflug, Sylvain Paisant, Vincent Navratil, Stephen Cusack, Nadia Naffakh

Journal: PLoS Pathog

PubMed ID: 35605026

Doi: 10.1371/journal.ppat.1010328

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Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants

Authors: Yaning Li, Qing Fan, Bing Zhou, Yaping Shen, Yuanyuan Zhang, Lin Cheng, Furong Qi, Shuo Song, Yingying Guo, Renhong Yan, Bin Ju, Zheng Zhang

Journal: iScience

PubMed ID: 35607524

Doi: 10.1016/j.isci.2022.104431

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