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Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2

Authors: Brandon Leonard, Kannan Sankar, Matthew G Romei, Margaret J Tse, Nina Do, Yanli Yang, Wadim L Matochko, Jack Bevers, Sundeep Bollineni, Kiran Mukhyala, Kam Hon Hoi, Greg A Lazar

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35653561

Doi: 10.1073/pnas.2201562119

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Persistence of immune responses to the Sinopharm/BBIBP-CorV vaccine

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Pradeep Darshana Pushpakumara, Achala Kamaladasa, Dinuka Guruge, Ayesha Wijesinghe, Banuri Gunasekera, Shyrar Tanussiya Ramu, Heshan Kuruppu, Thushali Ranasinghe, Shashika Dayarathna, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jeewantha Jayamali, Deshni Jayathilaka, Madushika Dissanayake, Tibutius Thanesh Jayadas, Anushika Mudunkotuwa, Gayasha Somathilake, Michael Harvie, Thashmi Nimasha, Saubhagya Danasekara, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K Tan, Tao Dong, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: Immun Inflamm Dis

PubMed ID: 35634958

Doi: 10.1002/iid3.621

Products & Services: Proteins, Expression, Isolation and Analysis

Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation

Authors: Julia E Page, Meredith A Skiba, Truc Do, Andrew C Kruse, Suzanne Walker

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35733252

Doi: 10.1073/pnas.2201141119

Products & Services: Proteins, Expression, Isolation and Analysis

Metabolic engineering of Yarrowia lipolytica for scutellarin production

Authors: Yina Wang , Xiaonan Liu , Bihuan Chen , Wei Liu , Zhaokuan Guo , Xiangyu Liu , Xiaoxi Zhu , Jiayu Liu , Jin Zhang , Jing Li , Lei Zhang , Yadi Gao , Guanghui Zhang , Yan Wang, M Iqbal Choudhary, Shengchao Yang , Huifeng Jiang

Journal: Synth Syst Biotechnol.

PubMed ID: 35756963

Doi: 10.1016/j.synbio.2022.05.009

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A chimeric MERS-CoV virus-like particle vaccine protects mice against MERS-CoV challenge

Authors: Jung-Eun Park, Ji-Hee Kim, Jae-Yeon Park, Sung-Hoon Jun, Hyun-Jin Shin

Journal: Virol J

PubMed ID: 35761402

Doi: 10.1186/s12985-022-01844-9

Products & Services: Mammalian Expression

Nuclear pore complex acetylation regulates mRNA export and cell cycle commitment in budding yeast

Authors: Mercè Gomar-Alba, Vasilisa Pozharskaia, Bogdan Cichocki, Celia Schaal, Arun Kumar, Basile Jacquel, Gilles Charvin, J Carlos Igual, Manuel Mendoza

Journal: EMBO J

PubMed ID: 35735140

Doi: 10.15252/embj.2021110271

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Extraoral expression and characterization of bitter taste receptors in (Mexican tetra fish)

Authors: Vikram Bhatia, Vivianne Cruz de Jesus, Feroz Ahmed Shaik, Appalaraju Jaggupilli, Nisha Singh, Prashen Chelikani, Devi Atukorallaya

Journal: FASEB Bioadv

PubMed ID: 36089978

Doi: 10.1096/fba.2022-00032

Products & Services: Recombinant Antibody Expression

A new Eimeria coccidian species (Apicomplexa: Eimeriidae) from Père David's deer (Elaphurus davidianus Milne-Edwards, 1866) in Dafeng Milu National Nature Reserve in Jiangsu Province, eastern China

Authors: Weimin Cai, Zeyang Suding, Lele Wang, Zhaofeng Hou, Dandan Liu, Siyang Huang, Jinjun Xu, Jianping Tao

Journal: BMC Vet Res

PubMed ID: 35655211

Doi: 10.1186/s12917-022-03308-2

Products & Services: GenParts™ DNA Fragments

Cloning, expression, and one-step purification/immobilization of two carbohydrate-binding module-tagged alcohol dehydrogenases

Authors: Mario Benito, Ramón Román, Garazi Ortiz, Antoni Casablancas, Gregorio Álvaro, Gloria Caminal, Gloria González, Marina Guillén

Journal: J Biol Eng

PubMed ID: 35765016

Doi: 10.1186/s13036-022-00295-8

Products & Services: GenParts™ DNA Fragments

Determination of the efficacy of using a serine protease gene as a DNA vaccine to protect against Vibrio parahaemolyticus infection in Litopenaeus vannamei

Authors: Naeem Madsari, Siriluk Maskaew, Sumalee Obchoei, Pattamaporn Kwankaew, Wilaiwan Senghoi, Prapaporn Utarabhand, Phanthipha Runsaeng

Journal: Dev Comp Immunol

PubMed ID: 35660488

Doi: 10.1016/j.dci.2022.104459

Products & Services: DNA Sequencing

Comparison of Selected Immune Parameters in a Single Infection and Co-Infection with Infectious Pancreatic Necrosis Virus with Other Viruses in Rainbow Trout

Authors: Joanna Maj-Paluch, Magdalena Wasiak, Łukasz Bocian, Michał Reichert

Journal: Pathogens

PubMed ID: 35745512

Doi: 10.3390/pathogens11060658

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Head-to-Head Comparison of 5 Anti-SARS-CoV-2 Assays Performance in One Hundred COVID-19 Vaccinees, over an 8-Month Course

Authors: Jakub Swadźba, Tomasz Anyszek, Andrzej Panek, Agnieszka Chojęta, Kinga Wyrzykowska, Emilia Martin

Journal: Diagnostics (Basel)

PubMed ID: 35741236

Doi: 10.3390/diagnostics12061426

Effect of Multivalency on Phase-Separated Droplets Consisting of Poly(PR) Dipeptide Repeats and RNA at the Solid/Liquid Interface

Authors: Chen Chen, Han Jia, Yoshiki Nakamura, Kohsuke Kanekura, Yuhei Hayamizu

Journal: ACS Omega

PubMed ID: 35721931

Doi: 10.1021/acsomega.2c00811

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Integrating In Vitro and In Silico Analysis of a Cationic Antimicrobial Peptide Interaction with Model Membranes of Colistin-Resistant Strains

Authors: Sandra Patricia Rivera-Sanchez, Iván Darío Ocampo-Ibáñez, Yamil Liscano, Natalia Martínez, Isamar Muñoz, Marcela Manrique-Moreno, Luis Martinez-Martinez, José Oñate-Garzon

Journal: Pharmaceutics

PubMed ID: 35745820

Doi: 10.3390/pharmaceutics14061248

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Template-Assisted Sequencing of SARS-CoV-2 and Influenza Monoclonal Antibodies by Mass Spectrometry

Authors: Michelle V Gadush, Giuseppe A Sautto, Hamssika Chandrasekaran, Alena Bensussan, Ted M Ross, Gregory C Ippolito, Maria D Person

Journal: J Proteome Res

PubMed ID: 35653804

Doi: 10.1021/acs.jproteome.1c00913

Products & Services: Mammalian Expression

Author Correction: Development of spirulina for the manufacture and oral delivery of protein therapeutics

Authors: Benjamin W Jester, Hui Zhao, Mesfin Gewe, Thomas Adame, Lisa Perruzza, David T Bolick, Jan Agosti, Nhi Khuong, Rolf Kuestner, Caitlin Gamble, Kendra Cruickshank, Jeremy Ferrara, Rachelle Lim, Troy Paddock, Colin Brady, Stacey Ertel, Miaohua Zhang, Alex Pollock, Jamie Lee, Jian Xiong, Michael Tasch, Tracy Saveria, David Doughty, Jacob Marshall, Damian Carrieri, Lauren Goetsch, Jason Dang, Nathaniel Sanjaya, David Fletcher, Anissa Martinez, Bryce Kadis, Kristjan Sigmar, Esha Afreen, Tammy Nguyen, Amanda Randolph, Alexandria Taber, Ashley Krzeszowski, Brittney Robinett, David B Volkin, Fabio Grassi, Richard Guerrant, Ryo Takeuchi, Brian Finrow, Craig Behnke, James Roberts

Journal: Nat Biotechnol

PubMed ID: 35440781

Doi: 10.1038/s41587-022-01323-0

Products & Services: Catalog Antibody

The Bufei Jianpi Formula Improves Mucosal Immune Function by Remodeling Gut Microbiota Through the SCFAs/GPR43/NLRP3 Pathway in Chronic Obstructive Pulmonary Disease Rats

Authors: Jing Mao, Ya Li, Qingqing Bian, Yinshuang Xuan, Jingmei Li, Zhikun Wang, Suxiang Feng, Xuefang Liu, Yange Tian, Suyun Li

Journal: Int J Chron Obstruct Pulmon Dis

PubMed ID: 35673595

Doi: 10.2147/COPD.S359428

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Time-dependent contraction of the SARS-CoV-2-specific T-cell responses in convalescent individuals

Authors: Edgar Ruz Fernandes, Juliana de Souza Apostolico, Lucas Cauê Jacintho, Maria Lucia Carnevale Marin, Roberto Carlos Vieira da Silva Júnior, Hélcio Rodrigues, Keity Souza Santos, Verônica Coelho, Silvia Beatriz Boscardin, Jorge Kalil, Edecio Cunha-Neto, Daniela Santoro Rosa

Journal: J Allergy Clin Immunol Glob

PubMed ID: 36203479

Doi: 10.1016/j.jacig.2022.05.002

Products & Services: Peptide Synthesis

Structure and Protein-Protein Interactions of Ice Nucleation Proteins Drive Their Activity

Authors: Susan Hartmann, Meilee Ling, Lasse S A Dreyer, Assaf Zipori, Kai Finster, Sarah Grawe, Lasse Z Jensen, Stella Borck, Naama Reicher, Taner Drace, Dennis Niedermeier, Nykola C Jones, Søren V Hoffmann, Heike Wex, Yinon Rudich, Thomas Boesen, Tina Šantl-Temkiv

Journal: Front Microbiol

PubMed ID: 35783412

Doi: 10.3389/fmicb.2022.872306

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of Chemical Probes Targeting MBD2

Authors: Diane Erdmann, Jean Contreras, Rémy A Le Meur, Bruno Vitorge, Vincent Saverat, Ambre Tafit, Corinne Jallet, Véronique Cadet-Daniel, Corentin Bon, Phannarath Phansavath, Virginie Ratovelomanana-Vidal, Albert Jeltsch, Sophie Vichier-Guerre, J Iñaki Guijarro, Paola B Arimondo

Journal: ACS Chem Biol

PubMed ID: 35649238

Doi: 10.1021/acschembio.1c00959

Products & Services: Proteins, Expression, Isolation and Analysis

Antibody-based redirection of universal Fabrack-CAR T cells selectively kill antigen bearing tumor cells

Authors: Yi-Chiu Kuo, Cheng-Fu Kuo, Kurt Jenkins, Alfur Fu-Hsin Hung, Wen-Chung Chang, Miso Park, Brenda Aguilar, Renate Starr, Jonathan Hibbard, Christine Brown, John C Williams

Journal: J Immunother Cancer

PubMed ID: 35728874

Doi: 10.1136/jitc-2021-003752

Products & Services: Proteins, Expression, Isolation and Analysis

Autoimmune neuroinflammation triggers mitochondrial oxidation in oligodendrocytes

Authors: Jasmin Steudler, Timothy Ecott, Daniela C Ivan, Elisa Bouillet, Sabrina Walthert, Kristina Berve, Tobias P Dick, Britta Engelhardt, Giuseppe Locatelli

Journal: Glia

PubMed ID: 35762739

Doi: 10.1002/glia.24235

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Improved yield of recombinant human IFN-α2b from mammalian cells using heterologous signal peptide approach

Authors: Claire Wilkinson, Jacob Kyle, Meghna Irimpen, Sarah Stuart, Shylaja Mohandass, Andrew Sheperd, Kathrine J Smith, Michael J Mullin

Journal: Protein Expr Purif

PubMed ID: 35659600

Doi: 10.1016/j.pep.2022.106125

Products & Services: Gene Synthesis

Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening

Authors: Rui Zheng, Wenhao Yang, Yuting Wen, Liang Xie, Fang Shi, Danli Lu, Jiaxin Luo, Yan Li, Rui Zhang, Ting Chen, Lina Chen, Wenming Xu, Hanmin Liu

Journal: Cell Death Dis

PubMed ID: 35729109

Doi: 10.1038/s41419-022-05010-5

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 Neutralizing Antibodies Kinetics Postvaccination in Cancer Patients under Treatment with Immune Checkpoint Inhibition

Authors: Evangelos Terpos, Michalis Liontos, Oraianthi Fiste, Flora Zagouri, Alexandros Briasoulis, Aimilia D Sklirou, Christos Markellos, Efthymia Skafida, Alkistis Papatheodoridi, Angeliki Andrikopoulou, Konstantinos Koutsoukos, Maria Kaparelou, Vassiliki A Iconomidou, Ioannis P Trougakos, Meletios-Athanasios Dimopoulos

Journal: Cancers (Basel)

PubMed ID: 35681774

Doi: 10.3390/cancers14112796

Vaccination after SARS-CoV-2 infection increased antibody avidity against the Omicron variant compared to vaccination alone

Authors: Cas LeMaster, Eric S Geanes, Elizabeth R Fraley, Rangaraj Selvarangan, Todd Bradley

Journal: J Infect Dis

PubMed ID: 35714328

Doi: 10.1093/infdis/jiac247

Products & Services: Recombinant Antibody Expression

Investigation of Product Ions Generated by 193 nm Ultraviolet Photodissociation of Peptides and Proteins Containing Disulfide Bonds

Authors: Luis A Macias, Jennifer S Brodbelt

Journal: J Am Soc Mass Spectrom

PubMed ID: 35736955

Doi: 10.1021/jasms.2c00124

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Simultaneous One-Pot Interpenetrating Network Formation to Expand 3D Processing Capabilities

Authors: Abhishek P Dhand, Matthew D Davidson, Jonathan H Galarraga, Taimoor H Qazi, Ryan C Locke, Robert L Mauck, Jason A Burdick

Journal: Adv Mater

PubMed ID: 35510317

Doi: 10.1002/adma.202202261

Products & Services: Proteins, Expression, Isolation and Analysis

Biochemical, structural, and functional studies reveal that MAB_4324c from Mycobacterium abscessus is an active tandem repeat N-acetyltransferase

Authors: Husam M A B Alsarraf, Kien Lam Ung, Matt D Johansen, Juliette Dimon, Vincent Olieric, Laurent Kremer, Mickaël Blaise

Journal: FEBS Lett

PubMed ID: 35470425

Doi: 10.1002/1873-3468.14360

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An epitope-optimized human H3N2 influenza vaccine induces broadly protective immunity in mice and ferrets

Authors: Brianna L Bullard, Jennifer DeBeauchamp, Matthew J Pekarek, Erika Petro-Turnquist, Peter Vogel, Richard J Webby, Eric A Weaver

Journal: npj Vaccines

PubMed ID: 35739199

Doi: 10.1038/s41541-022-00492-y

Products & Services: Mammalian Expression

miR-452-3p Targets HDAC3 to Inhibit p65 Deacetylation and Activate the NF-κB Signaling Pathway in Early Brain Injury after Subarachnoid Hemorrhage

Authors: Junti Lu, Xiaodong Huang, Aiping Deng, Hong Yao, Gao Wu, Na Wang, Hui Gui, Mojie Ren, Shiwen Guo

Journal: Neurocrit Care

PubMed ID: 35641805

Doi: 10.1007/s12028-022-01509-z

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A compact, low-cost, and binary sensing (BiSense) platform for noise-free and self-validated impedimetric detection of COVID-19 infected patients

Authors: Razieh Salahandish, Pezhman Jalali, Hamed Osouli Tabrizi, Jae Eun Hyun, Fatemeh Haghayegh, Mahmood Khalghollah, Azam Zare, Byron M Berenger, Yan Dong Niu, Ebrahim Ghafar-Zadeh, Amir Sanati-Nezhad

Journal: Biosens Bioelectron

PubMed ID: 35728365

Doi: 10.1016/j.bios.2022.114459

Products & Services: Proteins, Expression, Isolation and Analysis

Harnessing anti-cytomegalovirus immunity for local immunotherapy against solid tumors

Authors: Nicolas Çuburu, Lukasz Bialkowski, Sergio M Pontejo, Shiv K Sethi, Alexander T F Bell, Rina Kim, Cynthia D Thompson, Douglas R Lowy, John T Schiller

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35749366

Doi: 10.1073/pnas.2116738119

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Recapitulating early human development with 8C-like cells

Authors: Xiu Yu, Shiqi Liang, Manqi Chen, Hanwen Yu, Ruiqi Li, Yuliang Qu, Xuhui Kong, Ruirui Guo, Rongyan Zheng, Zsuzsanna Izsvák, Chuanbo Sun, Mingzhu Yang, Jichang Wang

Journal: Cell Rep

PubMed ID: 35732112

Doi: 10.1016/j.celrep.2022.110994

Products & Services: Proteins, Expression, Isolation and Analysis

Insights Into the Effect of Rice Stripe Virus P2 on Rice Defense by Comparative Proteomic Analysis

Authors: Zihang Yang, Hehong Zhang, Xiaoxiang Tan, Zhongyan Wei, Caiyi Wen, Zongtao Sun, Bingjian Sun, Jianping Chen

Journal: Front Microbiol

PubMed ID: 35747367

Doi: 10.3389/fmicb.2022.897589

Products & Services: Gene Synthesis

Construction of a synthetic Saccharomyces cerevisiae pan-genome neo-chromosome

Authors: Dariusz R Kutyna, Cristobal A Onetto, Thomas C Williams, Hugh D Goold, Ian T Paulsen, Isak S Pretorius, Daniel L Johnson, Anthony R Borneman

Journal: Nat Commun

PubMed ID: 35750675

Doi: 10.1038/s41467-022-31305-4

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Pore-Forming Cardiotoxin VVA2 (Volvatoxin A2) Variant I82E/L86K Is an Atypical Duplex-Specific Nuclease

Authors: Jia-Qi Lu, Jia-Wen Shou, Ka-Ching Lo, Yun-Sang Tang, Wei-Wei Shi, Pang-Chui Shaw

Journal: Toxins (Basel)

PubMed ID: 35737053

Doi: 10.3390/toxins14060392

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Structural analysis of LpqY, a substrate-binding protein from the SugABC transporter of Mycobacterium tuberculosis, provides insights into its trehalose specificity

Authors: Dipika Sharma, Mandeep Singh, Punit Kaur, Uddipan Das

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35775983

Doi: 10.1107/S2059798322005290

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Disease-linked mutations cause exposure of a protein quality control degron

Authors: Caroline Kampmeyer, Sven Larsen-Ledet, Morten Rose Wagnkilde, Mathias Michelsen, Henriette K M Iversen, Sofie V Nielsen, Søren Lindemose, Alberto Caregnato, Tommer Ravid, Amelie Stein, Kaare Teilum, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen

Journal: Structure

PubMed ID: 35700725

Doi: 10.1016/j.str.2022.05.016

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Duplication of horizontally acquired GH5_2 enzymes played a central role in the evolution of longhorned beetles

Authors: Na Ra Shin, Daniel Doucet, Yannick Pauchet

Journal: Mol Biol Evol

PubMed ID: 35763818

Doi: 10.1093/molbev/msac128

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DOC2b Enhances β-Cell Function via a Novel Tyrosine Phosphorylation-Dependent Mechanism

Authors: Diti Chatterjee Bhowmick, Arianne Aslamy, Supriyo Bhattacharya, Eunjin Oh, Miwon Ahn, Debbie C Thurmond

Journal: Diabetes

PubMed ID: 35377441

Doi: 10.2337/db21-0681

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A novel dual-targeting delivery system for specific delivery of CRISPR/Cas9 using hyaluronic acid, chitosan and AS1411

Authors: Zahra Khademi, Mohammad Ramezani, Mona Alibolandi, Mohammad Reza Zirak, Zahra Salmasi, Khalil Abnous, Seyed Mohammad Taghdisi

Journal: Carbohydr Polym

PubMed ID: 35725215

Doi: 10.1016/j.carbpol.2022.119691

Products & Services: Plasmid DNA Preparation

A Novel Flavi-like Virus in Alfalfa ( L) Crops along the Snake River Valley

Authors: Jennifer Dahan, Yuri I Wolf, Gardenia E Orellana, Erik J Wenninger, Eugene V Koonin, Alexander V Karasev

Journal: Viruses

PubMed ID: 35746792

Doi: 10.3390/v14061320

Products & Services: PCR and Cloning

Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1

Authors: Jianxiu Zhang, Ying-Ying Wang, Zhao-Qian Pan, Yulu Li, Jianhua Sui, Li-Lin Du, Keqiong Ye

Journal: Nat Commun

PubMed ID: 35752625

Doi: 10.1038/s41467-022-31439-5

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SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebraﬁsh

Authors: Fang Liang, Yu Zhang, Lin Li, Yexin Yang, Ji-Feng Fei, Yanmei Liu, Wei Qin

Journal: Nat Commun

PubMed ID: 35701400

Doi: 10.1038/s41467-022-31034-8

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Structure−Function Analysis of a Quinone-Dependent Dehydrogenase Capable of Deoxynivalenol Detoxification

Authors: Hua Yang , Ruxue Yan , Yue Li , Zhaoxin Lu , Xiaomei Bie , Haizhen Zhao , Fengxia Lu , Meirong Chen

Journal: J Agric Food Chem

PubMed ID: 35613468

Doi: 10.1021/acs.jafc.2c01083

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The Pre-Existing Human Antibody Repertoire to Computationally Optimized Influenza H1 Hemagglutinin Vaccines

Authors: Kaito Nagashima, John V Dzimianski, Julianna Han, Nada Abbadi, Aaron D Gingerich, Fredejah Royer, Sara O'Rourke, Giuseppe A Sautto, Ted M Ross, Andrew B Ward, Rebecca M DuBois, Jarrod J Mousa

Journal: J Immunol

PubMed ID: 35697384

Doi: 10.4049/jimmunol.2101171

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Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx

Authors: Tae Gun Kang, Kee Woong Kwon, Kyungsoo Kim, Insuk Lee, Myeong Joon Kim, Sang-Jun Ha, Sung Jae Shin

Journal: Nat Commun

PubMed ID: 35672321

Doi: 10.1038/s41467-022-30914-3

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Senescent cells limit p53 activity via multiple mechanisms to remain viable

Authors: Ines Sturmlechner, Chance C Sine, Karthik B Jeganathan, Cheng Zhang, Raul O Fierro Velasco, Darren J Baker, Hu Li, Jan M van Deursen

Journal: Nat Commun

PubMed ID: 35764649

Doi: 10.1038/s41467-022-31239-x

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of inositol lipid metabolism in gut-associated Bacteroidetes

Authors: Stacey L Heaver, Henry H Le, Peijun Tang, Arnaud Baslé, Claudia Mirretta Barone, Dai Long Vu, Jillian L Waters, Jon Marles-Wright, Elizabeth L Johnson, Dominic J Campopiano, Ruth E Ley

Journal: Nat Microbiol

PubMed ID: 35725777

Doi: 10.1038/s41564-022-01152-6

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Production of Plant Sesquiterpene Lactone Parthenolide in the Yeast Cell Factory

Authors: Yiting Shi, Tianyu Dong, Boxuan Zeng, Mingdong Yao, Ying Wang, Zexiong Xie, Wenhai Xiao, Yingjin Yuan

Journal: ACS Synth Biol

PubMed ID: 35723427

Doi: 10.1021/acssynbio.2c00132

Products & Services: Recombinant Antibody Expression

Human Superantibodies to 3CL Inhibit Replication of SARS-CoV-2 across Variants

Authors: Kittirat Glab-Ampai, Kanasap Kaewchim, Thanatsaran Saenlom, Watayagorn Thepsawat, Kodchakorn Mahasongkram, Nitat Sookrung, Wanpen Chaicumpa, Monrat Chulanetra

Journal: Int J Mol Sci

PubMed ID: 35743031

Doi: 10.3390/ijms23126587

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Development of a biosensor based on a new marine luciferase fused to an affibody to assess Her2 expression in living cells

Authors: Laura Rodríguez de la Fuente, Irene Golán Cancela, Ánxela M Estévez-Salguero, Pablo Iglesias, José A Costoya

Journal: Anal Chim Acta

PubMed ID: 35934341

Doi: 10.1016/j.aca.2022.340084

Products & Services: PCR Cloning and Subcloning

A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly

Authors: Francisco Figueiredo, Mónica Lopes-Marques, Bruno Almeida, Nena Matscheko, Pedro M Martins, Alexandra Silva, Sandra Macedo-Ribeiro

Journal: Cells

PubMed ID: 35741099

Doi: 10.3390/cells11121969

Products & Services: Proteins, Expression, Isolation and Analysis

Longitudinal profile of neutralizing and binding antibodies in vaccinated and convalescent COVID-19 cohorts by chemiluminescent immunoassays

Authors: Xiaowen Dou, Enyun Wang, Ruiwei Jiang, Min Li, Dan Xiong, Baoqing Sun, Xiuming Zhang

Journal: Immun Inflamm Dis

PubMed ID: 35634960

Doi: 10.1002/iid3.612

L and L Improve Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats through Suppression of Oxidative Stress

Authors: Shujun Jiang, Quanyan Cai, Yang Gao, Hui Dong, Yan Zhao, Fan Wu, Xin Ba, Yang Luan, Xin Zou, Lijun Xu, Fuer Lu

Journal: Evid Based Complement Alternat Med

PubMed ID: 35707467

Doi: 10.1155/2022/4187359

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The Cross-Protective Immunity Landscape Among Different SARS-CoV-2 Variant RBDs

Authors: Wenqiang Sun, Lihong He, Huicong Lou, Wenhui Fan, Limin Yang, Gong Cheng, Wenjun Liu, Lei Sun

Journal: Front Immunol

PubMed ID: 35757743

Doi: 10.3389/fimmu.2022.898520

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Activated Stellate Cell Paracrine HGF Exacerbated Pancreatic Cancer Cell Ferroptosis Resistance

Authors: Qiwei Wu, Lian Song, Yaxin Guo, Sai Liu, Wenyao Wang, Huli Liu, Aihua Gong, Xiang Liao, Haitao Zhu, Dongqing Wang

Journal: Oxid Med Cell Longev

PubMed ID: 35693705

Doi: 10.1155/2022/2985249

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Preclinical evaluation of a plant-derived SARS-CoV-2 subunit vaccine: Protective efficacy, immunogenicity, safety, and toxicity

Authors: Balamurugan Shanmugaraj, Narach Khorattanakulchai, Chalisa Panapitakkul, Ashwini Malla, Rawiwan Im-Erbsin, Manutsanun Inthawong, Piyanate Sunyakumthorn, Taweewun Hunsawong, Chonticha Klungthong, Matthew C Reed, Taratorn Kemthong, Nutchanat Suttisan, Suchinda Malaivijitnond, Passaraporn Srimangkornkaew, Aekkarin Klinkhamhom, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Suthira Taychakhoonavudh, Waranyoo Phoolcharoen

Journal: Vaccine

PubMed ID: 35697573

Doi: 10.1016/j.vaccine.2022.05.087

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Uricase sensitizes hepatocellular carcinoma cells to 5-fluorouracil through uricase-uric acid-UMP synthase axis

Authors: Saihong Yu, Zhuduo Li, Linglan Tu, Yiyi Pu, Dongmei Yan, Xiaoju Wang, Xiaoliang Zheng, Jie Yu

Journal: J Physiol Biochem

PubMed ID: 35674867

Doi: 10.1007/s13105-022-00894-5

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Chemoproteomic identification of CO-dependent lysine carboxylation in proteins

Authors: Dustin T King, Sha Zhu, Darryl B Hardie, Jesús E Serrano-Negrón, Zarina Madden, Subramania Kolappan, David J Vocadlo

Journal: Nat Chem Biol

PubMed ID: 35710617

Doi: 10.1038/s41589-022-01043-1

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Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA

Authors: Elena S Kim, Jun Zhou, Hu Zhang, Alexander Marchetti, Maarten van de Klundert, Dawei Cai, Xiaoyang Yu, Bidisha Mitra, Yuanjie Liu, Mu Wang, Ulrike Protzer, Haitao Guo

Journal: PLoS Pathog

PubMed ID: 35679251

Doi: 10.1371/journal.ppat.1010576

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Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors

Authors: Jiayue Su, Desheng Liu, Fan Yang, Mei-Qing Zuo, Chang Li, Meng-Qiu Dong, Shan Sun, Sen-Fang Sui

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35733257

Doi: 10.1073/pnas.2200158119

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Increased resistance of SARS-CoV-2 Lambda variant to antibody neutralization

Authors: Huimin Guo, Qing Fan, Shuo Song, Senlin Shen, Bing Zhou, Haiyan Wang, Lin Cheng, Xiangyang Ge, Bin Ju, Zheng Zhang

Journal: JOURNAL OF CLINICAL VIROLOGY

PubMed ID: 35461042

Doi: 10.1016/j.jcv.2022.105162

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Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease

Authors: Nikhil Panicker, Tae-In Kam, Hu Wang, Stewart Neifert, Shih-Ching Chou, Manoj Kumar, Saurav Brahmachari, Aanishaa Jhaldiyal, Jared T Hinkle, Fatih Akkentli, Xiaobo Mao, Enquan Xu, Senthilkumar S Karuppagounder, Eric T Hsu, Sung-Ung Kang, Olga Pletnikova, Juan Troncoso, Valina L Dawson, Ted M Dawson

Journal: Neuron

PubMed ID: 35654037

Doi: 10.1016/j.neuron.2022.05.009

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Histidine Ligated Iron-Sulfur Peptides

Authors: Luca Valer, Daniele Rossetto, Taylor Parkkila, Lorenzo Sebastianelli, Graziano Guella, Amber L Hendricks, James A Cowan, Lingzi Sang, Sheref S Mansy

Journal: Chembiochem

PubMed ID: 35674331

Doi: 10.1002/cbic.202200202

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The Effects of Qinghao-Kushen and Its Active Compounds on the Biological Characteristics of Liver Cancer Cells

Authors: Jingmin Ji, Zhiqin Zhang, Qing Peng, Liyuan Hao, Yinglin Guo, Yu Xue, Yiwei Liu, Caige Li, Xinli Shi

Journal: Evid Based Complement Alternat Med

PubMed ID: 35722140

Doi: 10.1155/2022/8763510

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Towards a general approach for tailoring the hydrophobic binding site of phenylalanine ammonia-lyases

Authors: Souad Diana Tork, Mădălina Elena Moisă, Lilla Cserepes, Alina Filip, Levente Csaba Nagy, Florin Dan Irimie, László Csaba Bencze

Journal: Sci Rep

PubMed ID: 35739148

Doi: 10.1038/s41598-022-14585-0

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Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes

Authors: Lucy C Walters, Daniel Rozbesky, Karl Harlos, Max Quastel, Hong Sun, Sebastian Springer, Robert P Rambo, Fiyaz Mohammed, E Yvonne Jones, Andrew J McMichael, Geraldine M Gillespie

Journal: Cell Rep

PubMed ID: 35705051

Doi: 10.1016/j.celrep.2022.110959

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Microfluidic T Cell Selection by Cellular Avidity

Authors: Julian F Ashby, Julien Schmidt, Neelima Kc, Armand Kurum, Caroline Koch, Alexandre Harari, Li Tang, Sam H Au

Journal: Adv Healthc Mater

PubMed ID: 35657072

Doi: 10.1002/adhm.202200169

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Successful Preservation of Native BCR::ABL1 in Chronic Myeloid Leukemia Primary Leukocytes Reveals a Reduced Kinase Activity

Authors: Christian Boni, Massimiliano Bonifacio, Marzia Vezzalini, Luigi Scaffidi, Luisa Tomasello, Laurie L Parker, Diego Boscarino, Dino Paladin, Mauro Krampera, Claudio Sorio

Journal: Front Oncol

PubMed ID: 35756686

Doi: 10.3389/fonc.2022.904510

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Comparative Characterization of Different Molecular Formats of Bispecific Antibodies Targeting EGFR and PD-L1

Authors: Nishant Mohan, Atul Agrawal, Yi Shen, Katie L Winarski, Yukinori Endo, Milos Dokmanovic, Deborah Schmiel, Jiwen Zheng, David S Rotstein, Lorraine C Pelosof, Wen Jin Wu

Journal: Pharmaceutics

PubMed ID: 35890277

Doi: 10.3390/pharmaceutics14071381

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The Use of Endo-Cellulase and Endo-Xylanase for the Extraction of Apple Pectins as Factors Modifying Their Anticancer Properties and Affecting Their Synergy with the Active Form of Irinotecan

Authors: Jerzy Maksymowicz, Anna Palko-Łabuz, Beata Sobieszczańska, Mateusz Chmielarz, Mirosława Ferens-Sieczkowska, Magdalena Skonieczna, Agnieszka Wikiera, Olga Wesołowska, Kamila Środa-Pomianek

Journal: Pharmaceuticals (Basel)

PubMed ID: 35745651

Doi: 10.3390/ph15060732

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Individual and Synergistic Anti-Coronavirus Activities of SOCS1/3 Antagonist and Interferon α1 Peptides

Authors: Chulbul M Ahmed, Tristan R Grams, David C Bloom, Howard M Johnson, Alfred S Lewin

Journal: Front Immunol

PubMed ID: 35799776

Doi: 10.3389/fimmu.2022.902956

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SASH1 knockdown suppresses TRAF6 ubiquitination to regulate hemangioma progression by mediating EZH2 degradation

Authors: Xueyuan Yu, Nuonuo Cong, Xiangyu Liu, Rui Wang, Daxu Li

Journal: Exp Cell Res

PubMed ID: 35772492

Doi: 10.1016/j.yexcr.2022.113270

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Inhibition of histone acetyltransferase GCN5 by a transcription factor FgPacC controls fungal adaption to host-derived iron stress

Authors: Qin Gu, Yujie Wang, Xiaozhen Zhao, Bingqin Yuan, Mengxuan Zhang, Zheng Tan, Xinyue Zhang, Yun Chen, Huijun Wu, Yuming Luo, Nancy P Keller, Xuewen Gao, Zhonghua Ma

Journal: Nucleic Acids Res

PubMed ID: 35687128

Doi: 10.1093/nar/gkac498

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Immunogenicity of Varicella Zoster Virus DNA Vaccines Encoding Glycoprotein E and Immediate Early Protein 63 in Mice

Authors: Jie Liu, Junyang Lin, Linjun Cai, Jie Sun, Xue Ding, Cenrong Wang, Yanchun Wu, Xiaoling Gao, Weiheng Su, Chunlai Jiang

Journal: Viruses

PubMed ID: 35746685

Doi: 10.3390/v14061214

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LncRNA RAD51-AS1 Regulates Human Bone Marrow Mesenchymal Stem Cells via Interaction with YBX1 to Ameliorate Osteoporosis

Authors: Beichen Li, Jing Wang, Fangrong Xu, Qinjue Wang, Quan Liu, Guantong Wang, Dengshun Miao, Qiang Sun

Journal: Stem Cell Rev Rep

PubMed ID: 35727431

Doi: 10.1007/s12015-022-10408-x

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Investigating the specificity of endothelin-traps as a potential therapeutic tool for endothelin-1 related disorders

Authors: Arjun Jain, Kristof Bozovicar, Vidhi Mehrotra, Tomaz Bratkovic, Martin H Johnson, Ira Jha

Journal: World J Diabetes

PubMed ID: 35800412

Doi: 10.4239/wjd.v13.i6.434

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Arabidopsis HOPS subunit VPS41 carries out plant-specific roles in vacuolar transport and vegetative growth

Authors: Dong Jiang, Yilin He, Xiangui Zhou, Zhiran Cao, Lei Pang, Sheng Zhong, Liwen Jiang, Ruixi Li

Journal: Plant Physiol

PubMed ID: 35417008

Doi: 10.1093/plphys/kiac167

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A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine

Authors: Jeeva Subbiah, Judy Oh, Ki-Hye Kim, Chong-Hyun Shin, Bo Ryoung Park, Noopur Bhatnagar, Baik-Lin Seong, Bao-Zhong Wang, Sang-Moo Kang

Journal: npj Vaccines

PubMed ID: 35768475

Doi: 10.1038/s41541-022-00498-6

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Sequence-specific H, C and N backbone NMR assignments for the N-terminal IgV-like domain (D1) and full extracellular region (D1D2) of PD-L1

Authors: Kayleigh Walker, Lorna C Waters, Geoff Kelly, Frederick W Muskett, Mark D Carr

Journal: Biomol NMR Assign

PubMed ID: 35675028

Doi: 10.1007/s12104-022-10092-5

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Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant

Authors: Kirsten E Lyke, Robert L Atmar, Clara Dominguez Islas, Christine M Posavad, Daniel Szydlo, Rahul Paul Chourdhury, Meagan E Deming, Amanda Eaton, Lisa A Jackson, Angela R Branche, Hana M El Sahly, Christina A Rostad, Judith M Martin, Christine Johnston, Richard E Rupp, Mark J Mulligan, Rebecca C Brady, Robert W Frenck, Martín Bäcker, Angelica C Kottkamp, Tara M Babu, Kumaravel Rajakumar, Srilatha Edupuganti, David Dobrzynski, Rhea N Coler, Janet I Archer, Sonja Crandon, Jillian A Zemanek, Elizabeth R Brown, Kathleen M Neuzil, David S Stephens, Diane J Post, Seema U Nayak, Mehul S Suthar, Paul C Roberts, John H Beigel, David C Montefiori

Journal: Cell Rep Med

PubMed ID: 35798000

Doi: 10.1016/j.xcrm.2022.100679

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Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses

Authors: Ghizlane Maarifi, Marie-France Martin, Abderezak Zebboudj, Aude Boulay, Pierre Nouaux, Juliette Fernandez, Justine Lagisquet, Dominique Garcin, Raphael Gaudin, Nathalie J Arhel, Sébastien Nisole

Journal: Cell Chem Biol

PubMed ID: 35728599

Doi: 10.1016/j.chembiol.2022.05.009

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Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity-Making Mutations

Authors: Juan Luis Pacheco-Garcia, Dmitry S Loginov, Ernesto Anoz-Carbonell, Pavla Vankova, Rogelio Palomino-Morales, Eduardo Salido, Petr Man, Milagros Medina, Athi N Naganathan, Angel L Pey

Journal: Antioxidants (Basel)

PubMed ID: 35740007

Doi: 10.3390/antiox11061110

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Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2

Authors: Maria Martinez-Molledo, Emmanuel Nji, Nicolas Reyes

Journal: Nat Struct Mol Biol

PubMed ID: 35710838

Doi: 10.1038/s41594-022-00786-8

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Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in

Authors: Xiaolu Tai, Yaqun Zhang, Jindong Yao, Xuan Li, Jun Liu, Jiazhen Han, Jianjun Lyu, Gufa Lin, Chao Zhang

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35795143

Doi: 10.3389/fendo.2022.892407

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Altered gut microbiota and metabolites profile are associated with reduced bone metabolism in ethanol-induced osteoporosis

Authors: Zhao Liu, Xilin Xu, Yiwei Shen, Yuanyuan Hao, Wenwen Cui, Wenyan Li, Xin Zhang, Hang Lv, Xiaodong Li, Yunlong Hou, Xiaofeng Zhang

Journal: Cell Prolif

PubMed ID: 35688648

Doi: 10.1111/cpr.13245

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Deletion of COM donor and acceptor domains and the interaction between modules in bacillomycin D produced by

Authors: Ziyan Lv, Wenjie Ma, Ping Zhang, Zhaoxin Lu, Libang Zhou, Fanqiang Meng, Zuwei Wang, Xiaomei Bie

Journal: Synth Syst Biotechnol

PubMed ID: 35782484

Doi: 10.1016/j.synbio.2022.05.007

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Pre-existing immunity modulates responses to mRNA boosters

Authors: Tanushree Dangi, Sarah Sanchez, Min Han Lew, Lavanya Visvabharathy, Justin Richner, Igor J Koralnik, Pablo Penaloza-MacMaster

Journal: biorxiv

PubMed ID: 35794898

Doi: 10.1101/2022.06.27.497248

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mRNA Booster Vaccination Enhances Antibody Responses against SARS-CoV2 Omicron Variant in Individuals Primed with mRNA or Inactivated Virus Vaccines

Authors: Biyan Zhang, Jianxin Huo, Yuhan Huang, Shuan Yong Teo, Kaibo Duan, Yanfeng Li, Lim Kai Toh, Kong Peng Lam, Shengli Xu

Journal: Vaccines (Basel)

PubMed ID: 35891221

Doi: 10.3390/vaccines10071057

RNA Polymerase II Transcription in : TFIIB from Can Replace the Transcriptional Functions of Fission Yeast TFIIB In Vivo and In Vitro

Authors: Diego A Rojas, Fabiola Urbina, Aldo Solari, Edio Maldonado

Journal: Int J Mol Sci

PubMed ID: 35743306

Doi: 10.3390/ijms23126865

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Dynamic transcriptome profiling reveals essential roles of the receptor tyrosine kinases (RTK) family in feather development of duck

Authors: H Liu, Q Xu, Y Xi, S Ma, J Wang, L Bai, C Han, H He, L Li

Journal: Br Poult Sci

PubMed ID: 35383522

Doi: 10.1080/00071668.2022.2061839

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Immunological characteristics of MAV/06 strain of varicella-zoster virus vaccine in an animal model

Authors: Duckhyang Shin, Younchul Shin, Eunmi Kim, Hyojung Nam, Haiyan Nan, Jaewoo Lee

Journal: BMC Immunol

PubMed ID: 35658899

Doi: 10.1186/s12865-022-00503-6

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The optimal docking strength for reversibly tethered kinases

Authors: Mateusz Dyla, Nicolás S González Foutel, Daniel E Otzen, Magnus Kjaergaard

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35696590

Doi: 10.1073/pnas.2203098119

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In silico screening and heterologous expression of soluble dimethyl sulfide monooxygenases of microbial origin in Escherichia coli

Authors: Prasanth Karaiyan, Catherine Ching Han Chang, Eng-Seng Chan, Beng Ti Tey, Ramakrishnan Nagasundara Ramanan, Chien Wei Ooi

Journal: Appl Microbiol Biotechnol

PubMed ID: 35713659

Doi: 10.1007/s00253-022-12008-8

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Independent pathways control muscle tissue size and sarcomere remodeling

Authors: David Brooks, Simranjot Bawa, Alexandria Bontrager, Marta Stetsiv, Yungui Guo, Erika R Geisbrecht

Journal: Dev Biol

PubMed ID: 35760368

Doi: 10.1016/j.ydbio.2022.06.014

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Preclinical study of formulated recombinant nucleocapsid protein, the receptor binding domain of the spike protein, and truncated spike (S1) protein as vaccine candidates against COVID-19 in animal models

Authors: Shahram Nazarian, Gholamreza Olad, Raziyeh Abdolhamidi, Mohammad Javad Motamedi, Rouhollah Kazemi, Emad Kordbacheh, Alireza Felagari, Hanieh Olad, Ali Ahmadi, Alireza Bahiraee, Parisa Farahani, Leila Haghighi, Faezeh Hassani, Vahideh Hajhassan, Mona Nadi, Abdolkarim Sheikhi, Jafar Salimian, Jafar Amani

Journal: Mol Immunol

PubMed ID: 35802999

Doi: 10.1016/j.molimm.2022.06.007

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Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

Authors: Daniel A Michelson, Koji Hase, Tsuneyasu Kaisho, Christophe Benoist, Diane Mathis

Journal: Cell

PubMed ID: 35714609

Doi: 10.1016/j.cell.2022.05.018

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Novel Mutations Associated With Epilepsy and Impacts on Neuronal Excitability

Authors: Changning Xie, Fangyun Liu, Hailan He, Fang He, Leilei Mao, Xiaole Wang, Fei Yin, Jing Peng

Journal: Front Mol Neurosci

PubMed ID: 35845605

Doi: 10.3389/fnmol.2022.870182

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