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PBP1 plays key roles in sex pheromone reception of the fall armyworm

Authors: Yongzhi Zhong, Minghui Xie, Zhongjuan Di, Fengqi Li, Jiaqi Chen, Xiangxin Kong, Lulu Lin, Weihua Su, Lina Xu, Feng Zhang, Rui Tang, Haoliang Chen

Journal: Int J Biol Macromol

PubMed ID: 35709868

Doi: 10.1016/j.ijbiomac.2022.06.068

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization, expression and function of the pyrokinins (PKs) in the giant freshwater prawn, Macrobrachium rosenbergii

Authors: Tipsuda Thongbuakaew, Sirirak Mukem, Arada Chaiyamoon, Kanjana Khornchatri, Thanapong Kruangkum, Scott F Cummins, Prasert Sobhon

Journal: J Exp Biol

PubMed ID: 35578905

Doi: 10.1242/jeb.243742

Products & Services: Peptide Synthesis

Expression optimization, purification, and biophysical characterization of a GluN2D-containing NMDA receptor

Authors: Aram Chang, Justin M Liu, Katrina Nguyen, P Rajesh Kumar

Journal: Protein Expr Purif

PubMed ID: 35752385

Doi: 10.1016/j.pep.2022.106129

Products & Services: Mammalian Expression

Inactivated whole-virion vaccine BBV152/Covaxin elicits robust cellular immune memory to SARS-CoV-2 and variants of concern

Authors: Rajesh Vikkurthi, Asgar Ansari, Anupama R Pai, Someshwar Nath Jha, Shilpa Sachan, Suvechchha Pandit, Bhushan Nikam, Anurag Kalia, Bimal Prasad Jit, Hilal Ahmad Parray, Savita Singh, Pallavi Kshetrapal, Nitya Wadhwa, Tripti Shrivastava, Poonam Coshic, Suresh Kumar, Pragya Sharma, Nandini Sharma, Juhi Taneja, Anil K Pandey, Ashok Sharma, Ramachandran Thiruvengadam, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Shinjini Bhatnagar, Nimesh Gupta

Journal: Nat Microbiol

PubMed ID: 35681012

Doi: 10.1038/s41564-022-01161-5

Products & Services: Recombinant Proteins

Long Intergenic Noncoding RNA MIAT as a Regulator of Human Th17 Cell Differentiation

Authors: Mohd Moin Khan, Meraj Hasan Khan, Ubaid Ullah Kalim, Sofia Khan, Sini Junttila, Niklas Paulin, Lingjia Kong, Omid Rasool, Laura L Elo, Riitta Lahesmaa

Journal: Front Immunol

PubMed ID: 35784351

Doi: 10.3389/fimmu.2022.856762

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Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT

Authors: Xuefang Pan, Mahsa Taherzadeh, Poulomee Bose, Rachel Heon-Roberts, Annie L A Nguyen, TianMeng Xu, Camila Pará, Yojiro Yamanaka, David A Priestman, Frances M Platt, Shaukat Khan, Nidhi Fnu, Shunji Tomatsu, Carlos R Morales, Alexey V Pshezhetsky

Journal: J Exp Med

PubMed ID: 35704026

Doi: 10.1084/jem.20211860

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Increasing the resilience of plant immunity to a warming climate

Authors: Jong Hum Kim, Christian Danve M Castroverde, Shuai Huang, Chao Li, Richard Hilleary, Adam Seroka, Reza Sohrabi, Diana Medina-Yerena, Bethany Huot, Jie Wang, Kinya Nomura, Sharon K Marr, Mary C Wildermuth, Tao Chen, John D MacMicking, Sheng Yang He

Journal: Nature

PubMed ID: 35768511

Doi: 10.1038/s41586-022-04902-y

Products & Services: Proteins, Expression, Isolation and Analysis

TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules

Authors: Andrew C McShan, Christine A Devlin, Georgia F Papadaki, Yi Sun, Adam I Green, Giora I Morozov, George M Burslem, Erik Procko, Nikolaos G Sgourakis

Journal: Nat Chem Biol

PubMed ID: 35725941

Doi: 10.1038/s41589-022-01049-9

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Biosynthetic potential of the global ocean microbiome

Authors: Lucas Paoli, Hans-Joachim Ruscheweyh, Clarissa C Forneris, Florian Hubrich, Satria Kautsar, Agneya Bhushan, Alessandro Lotti, Quentin Clayssen, Guillem Salazar, Alessio Milanese, Charlotte I Carlström, Chrysa Papadopoulou, Daniel Gehrig, Mikhail Karasikov, Harun Mustafa, Martin Larralde, Laura M Carroll, Pablo Sánchez, Ahmed A Zayed, Dylan R Cronin, Silvia G Acinas, Peer Bork, Chris Bowler, Tom O Delmont, Josep M Gasol, Alvar D Gossert, André Kahles, Matthew B Sullivan, Patrick Wincker, Georg Zeller, Serina L Robinson, Jörn Piel, Shinichi Sunagawa

Journal: Nature

PubMed ID: 35732736

Doi: 10.1038/s41586-022-04862-3

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Detection of the SARS-CoV-2 D614G Mutation Using VirSNiP SARS-CoV-2 Spike D614G Assay

Authors: Chih-Chieh Chen, Tze-Kiong Er

Journal: Clin Lab

PubMed ID: 35704738

Doi: 10.7754/Clin.Lab.2021.211009

Products & Services: Mutant Libraries

Development and Evaluation of Rapid and Accurate CRISPR/Cas13-Based RNA Diagnostics for Pneumonia

Authors: Yangqing Zhan, Xiaoqing Gao, Shaoqiang Li, Yeqi Si, Yuanxiang Li, Xu Han, Wenjun Sun, Zhengtu Li, Feng Ye

Journal: Front Cell Infect Microbiol

PubMed ID: 35782118

Doi: 10.3389/fcimb.2022.904485

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Identification and Characterization of an RRM-Containing, RNA Binding Protein in

Authors: Caterina Ciani, Anna Pérez-Ràfols, Isabelle Bonomo, Mariachiara Micaelli, Alfonso Esposito, Chiara Zucal, Romina Belli, Vito Giuseppe D'Agostino, Irene Bianconi, Vito Calderone, Linda Cerofolini, Orietta Massidda, Michael Bernard Whalen, Marco Fragai, Alessandro Provenzani

Journal: Biomolecules

PubMed ID: 35883478

Doi: 10.3390/biom12070922

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Immunogenicity of candidate SARS-CoV-2 DNA vaccines based on the spike protein

Authors: Heeji Lim, Se Eun Kim, Yun Ha Lee, Yun-Ho Hwang, Su Hwan Kim, Mi Young Kim, Gyung Tae Chung, You-Jin Kim, Dokeun Kim, Jung-Ah Lee

Journal: Virology

PubMed ID: 35751974

Doi: 10.1016/j.virol.2022.06.006

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Anti-spike protein antibody responses to BNT162b2 mRNA vaccine: A single-center survey in a COVID-19 non-epidemic area in Japan

Authors: Sho Mokuda, Namiki Kawanishi, Shintaro Kuroshima, Junko Kono, Hirofumi Nakayama, Hiroshi Mieno, Masashi Kawamoto

Journal: Vaccine X

PubMed ID: 35692460

Doi: 10.1016/j.jvacx.2022.100173

Products & Services: Proteins, Expression, Isolation and Analysis

Tip60 acetylation of histone H3K4 temporally controls chromosome passenger complex localization

Authors: Ewa Niedzialkowska, Limin Liu, Cem Kuscu, Zachary Mayo, Wladek Minor, Brian D Strahl, Mazhar Adli, P Todd Stukenberg

Journal: Mol Biol Cell

PubMed ID: 35653296

Doi: 10.1091/mbc.E21-06-0283

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Rapid titration of recombinant baculoviruses based on NanoLuc secretion in early infection

Authors: Jige Li, Meng Xu, Juan Sun, Junjun Li, Jianqing Chen, Qin Chen, Jian Chen

Journal: J Virol Methods

PubMed ID: 35728698

Doi: 10.1016/j.jviromet.2022.114565

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Role of PIM2 in acute lung injury induced by sepsis

Authors: Juncai Ding, Xiufang Yang, Huijuan Huang, Bo Wang

Journal: Exp Ther Med

PubMed ID: 35978927

Doi: 10.3892/etm.2022.11480

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ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia

Authors: Linjiang Lao, Isabelle Bourdeau, Lucia Gagliardi, Xiao He, Wei Shi, Bingbing Hao, Minjia Tan, Yan Hu, Junzheng Peng, Benoit Coulombe, David J Torpy, Hamish S Scott, Andre Lacroix, Hongyu Luo, Jiangping Wu

Journal: Nucleic Acids Res

PubMed ID: 35687106

Doi: 10.1093/nar/gkac483

Products & Services: Proteins, Expression, Isolation and Analysis

A structural vaccinology approach for in silico designing of a potential self-assembled nanovaccine against Leishmania infantum

Authors: Bahareh Vakili, Navid Nezafat, Manica Negahdaripour, Younes Ghasemi

Journal: Exp Parasitol

PubMed ID: 35709889

Doi: 10.1016/j.exppara.2022.108295

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Cross-Reactivity of IgG Antibodies and Virus Neutralization in mRNA-Vaccinated People Against Wild-Type SARS-CoV-2 and the Five Most Common SARS-CoV-2 Variants of Concern

Authors: Mandy Schwarze, Andor Krizsan, Alexandra Brakel, Fabian Pohl, Daniela Volke, Ralf Hoffmann

Journal: Front Immunol

PubMed ID: 35784285

Doi: 10.3389/fimmu.2022.915034

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bFGF-Loaded Mesoporous Silica Nanoparticles Promote Bone Regeneration Through the Wnt/β-Catenin Signalling Pathway

Authors: Mingkui Shen, Lulu Wang, Li Feng, Yi Gao, Sijing Li, Yulan Wu, Chuangye Xu, Guoxian Pei

Journal: Int J Nanomedicine

PubMed ID: 35698561

Doi: 10.2147/IJN.S366926

Products & Services: Proteins, Expression, Isolation and Analysis

Potentiating adoptive cell therapy using synthetic IL-9 receptors

Authors: Anusha Kalbasi, Mikko Siurala, Leon L Su, Mito Tariveranmoshabad, Lora K Picton, Pranali Ravikumar, Peng Li, Jian-Xin Lin, Helena Escuin-Ordinas, Tong Da, Sarah V Kremer, Amy L Sun, Sofia Castelli, Sangya Agarwal, John Scholler, Decheng Song, Philipp C Rommel, Enrico Radaelli, Regina M Young, Warren J Leonard, Antoni Ribas, Carl H June, K Christopher Garcia

Journal: Nature

PubMed ID: 35676488

Doi: 10.1038/s41586-022-04801-2

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Construction and Characterization of T7 Bacteriophages Harboring Apidaecin-Derived Sequences

Authors: Tobias Ludwig, Ralf Hoffmann, Andor Krizsan

Journal: Curr Issues Mol Biol

PubMed ID: 35735615

Doi: 10.3390/cimb44060174

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Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents

Authors: Jaime S Rosa Duque, Xiwei Wang, Daniel Leung, Samuel M S Cheng, Carolyn A Cohen, Xiaofeng Mu, Asmaa Hachim, Yanmei Zhang, Sau Man Chan, Sara Chaothai, Kelvin K H Kwan, Karl C K Chan, John K C Li, Leo L H Luk, Leo C H Tsang, Wilfred H S Wong, Cheuk Hei Cheang, Timothy K Hung, Jennifer H Y Lam, Gilbert T Chua, Winnie W Y Tso, Patrick Ip, Masashi Mori, Niloufar Kavian, Wing Hang Leung, Sophie Valkenburg, Malik Peiris, Wenwei Tu, Yu Lung Lau

Journal: Nat Commun

PubMed ID: 35764637

Doi: 10.1038/s41467-022-31485-z

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PD-1 and ICOS coexpression identifies tumor-reactive CD4+ T cells in human solid tumors

Authors: Rebekka Duhen, Olivier Fesneau, Kimberly A Samson, Alexandra K Frye, Michael Beymer, Venkatesh Rajamanickam, David Ross, Eric Tran, Brady Bernard, Andrew D Weinberg, Thomas Duhen

Journal: J Clin Invest

PubMed ID: 35439168

Doi: 10.1172/JCI156821

Products & Services: Gene Synthesis

The DUX4 protein is a co-repressor of the progesterone and glucocorticoid nuclear receptors

Authors: Julieta Quintero, Nizar Y Saad, Sabrina M Pagnoni, Daniela K Jacquelin, Laura V Gatica, Scott Q Harper, Alberto L Rosa

Journal: FEBS Lett

PubMed ID: 35662006

Doi: 10.1002/1873-3468.14416

Products & Services: Mutant Libraries

Kinetics of immune responses to SARS-CoV-2 proteins in individuals with varying severity of infection and following a single dose of the AZD1222

Authors: Deshni Jayathilaka, Chandima Jeewandara, Laksiri Gomes, Tibutius Thanesh Pramanayagam Jayadas, Achala Kamaladasa, Gayasha Somathilake, Dinuka Guruge, Pradeep Darshana Pushpakumara, Thushali Ranasinghe, Inoka Sepali Aberathna, Saubhagya Danasekara, Buddini Gunathilaka, Heshan Kuruppu, Ananda Wijewickrama, Ruwan Wijayamuni, Lisa Schimanski, T K Tan, Graham S Ogg, Alain Townsend, Gathsaurie Neelika Malavige

Journal: Clin Exp Immunol

PubMed ID: 35641142

Doi: 10.1093/cei/uxac009

Products & Services: Recombinant Antibody Expression

Tailored protein-conjugated DNA nanoplatform for synergistic cancer therapy

Authors: Dingkang Liu, Ye Chen, Qun Wang, Yue Ji, Lichen Bao, Wenbing Yao, Xiangdong Gao, Jun Yin

Journal: Journal of controlled release

PubMed ID: 35452765

Doi: 10.1016/j.jconrel.2022.04.022

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LncRNA LEMD1-AS1 relieves chondrocyte inflammation by targeting miR-944/PGAP1 in osteoarthritis

Authors: Haitao Li, Kaihua Lian, Jianguang Mao, Fuguo Huang, Chunli Zhang, Jianguo Zang

Journal: Cell Cycle

PubMed ID: 35686740

Doi: 10.1080/15384101.2022.2084294

Products & Services: Proteins, Expression, Isolation and Analysis

Phosphorylation of serine residues S252, S268/S269, and S879 in p120 catenin activates migration of presomitic mesoderm in gastrulating zebrafish embryos

Authors: Ariana Kupai, Hiroko Nakahara, Kathleen M Voss, Matthew S Hirano, Alexis Rodriguez, Donna L Lackey, James F Murayama, Chase J Mathieson, Botao Shan, Emma C Horton, Grace H Curtis, Joyce Huang, Merrill B Hille

Journal: Dev Dyn

PubMed ID: 35706088

Doi: 10.1002/dvdy.508

Products & Services: Mutant Libraries

Structures and mechanism of the plant PIN-FORMED auxin transporter

Authors: Kien Lam Ung, Mikael Winkler, Lukas Schulz, Martina Kolb, Dorina P Janacek, Emil Dedic, David L Stokes, Ulrich Z Hammes, Bjørn Panyella Pedersen

Journal: Nature

PubMed ID: 35768502

Doi: 10.1038/s41586-022-04883-y

Products & Services: Proteins, Expression, Isolation and Analysis

HA and M2 sequences alter the replication of 2013-16 H1 live attenuated influenza vaccine infection in human nasal epithelial cell cultures

Authors: Laura M Canaday, Jessica D Resnick, Hsuan Liu, Harrison Powell, Alyssa M McCoy, Dat Nguyen, Andrew Pekosz

Journal: Vaccine

PubMed ID: 35718589

Doi: 10.1016/j.vaccine.2022.05.088

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ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

Authors: William Hancock-Cerutti, Zheng Wu, Peng Xu, Narayana Yadavalli, Marianna Leonzino, Arun Kumar Tharkeshwar, Shawn M Ferguson, Gerald S Shadel, Pietro De Camilli

Journal: J Cell Biol

PubMed ID: 35657605

Doi: 10.1083/jcb.202106046

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De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts

Authors: Yameng Xu, Xinglong Wang, Chenyang Zhang, Xuan Zhou, Xianhao Xu, Luyao Han, Xueqin Lv, Yanfeng Liu, Song Liu, Jianghua Li, Guocheng Du, Jian Chen, Rodrigo Ledesma-Amaro, Long Liu

Journal: Nat Commun

PubMed ID: 35650215

Doi: 10.1038/s41467-022-30826-2

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Using large-scale multi-module NRPS to heterologously prepare highly efficient lipopeptide biosurfactants in recombinant Escherichia coli

Authors: Ting Zhang , Qiang Zhou

Journal: Enzyme Microb Technol

PubMed ID: 35660853

Doi: doi.org/10.1016/j.enzmictec.2022.110068

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Gold Glyconanoparticles Combined with 91-99 Peptide of the Bacterial Toxin, Listeriolysin O, Are Efficient Immunotherapies in Experimental Bladder Tumors

Authors: Hector Terán-Navarro, Andrea Zeoli, David Salines-Cuevas, Marco Marradi, Noemi Montoya, Elena Gonzalez-Lopez, Javier Gonzalo Ocejo-Vinyals, Mario Dominguez-Esteban, Jose Luis Gutierrez-Baños, Felix Campos-Juanatey, Sonsoles Yañez-Diaz, Almudena Garcia-Castaño, Fernando Rivera, Ignacio Duran, Carmen Alvarez-Dominguez

Journal: Cancers (Basel)

PubMed ID: 35626016

Doi: 10.3390/cancers14102413

Products & Services: Proteins, Expression, Isolation and Analysis

A Novel Small RNA, DsrO, in Deinococcus radiodurans Promotes Methionine Sulfoxide Reductase () Expression for Oxidative Stress Adaptation

Authors: Yun Chen, Mingming Zhao, Mengli Lv, Min Lin, Jin Wang, Kaijing Zuo

Journal: Appl Environ Microbiol

PubMed ID: 35575549

Doi: 10.1128/aem.00038-22

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AntiV-SGN: a universal antiviral strategy to combat both RNA and DNA viruses by destroying their nucleic acids without sequence limitation

Authors: Kun Tian, Zhen Qi, Ying Chi, Huanran Qiang, Pei Wang, Yu Liu, Guohua Zhou, Fengcai Zhu, Qinglong Guo, Shu Xu

Journal: Microb Biotechnol

PubMed ID: 35611874

Doi: 10.1111/1751-7915.14076

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Selenium in Proteins: Conformational Changes Induced by Se Substitution on Methionine, as Studied in Isolated Model Peptides by Optical Spectroscopy and Quantum Chemistry

Authors: Gildas Goldsztejn, Venkateswara Rao Mundlapati, Valérie Brenner, Eric Gloaguen, Michel Mons

Journal: Molecules

PubMed ID: 35630640

Doi: 10.3390/molecules27103163

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Potent and pan-neutralization of SARS-CoV-2 variants of concern by DARPins

Authors: Vikas Chonira, Young Do Kwon, Jason Gorman, James Brett Case, Zhiqiang Ku, Rudo Simeon, Ryan G Casner, Darcy R Harris, Adam S Olia, Tyler Stephens, Lawrence Shapiro, Hannah Boyd, Yaroslav Tsybovsky, Florian Krammer, Michael S Diamond, Peter D Kwong, Zhiqiang An, Zhilei Chen

Journal: biorxiv

PubMed ID: 35677079

Doi: 10.1101/2022.05.30.493765

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Developing G value as an indicator for assessing the molecular status of immobilized antibody

Authors: Dongdong Gao, Fang Cheng, Xinglong Wang, Heqing Yang, Chong Liu, Chunmei Li, Eva Murong Yang, Gang Cheng, Wei He

Journal: Colloids Surf B Biointerfaces

PubMed ID: 35665639

Doi: 10.1016/j.colsurfb.2022.112593

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New insights into the mechanism of iron transport through the bacterial Ftr system present in pathogens

Authors: Anne Soisig Steunou, Armelle Vigouroux, Magali Aumont-Nicaise, Stéphane Plancqueel, Alain Boussac, Soufian Ouchane, Solange Moréra

Journal: FEBS J

PubMed ID: 35527501

Doi: 10.1111/febs.16476

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α-Synuclein Impacts on Intrinsic Neuronal Network Activity Through Reduced Levels of Cyclic AMP and Diminished Numbers of Active Presynaptic Terminals

Authors: Kristian Leite, Pretty Garg, F Paul Spitzner, Sofia Guerin Darvas, Mathias Bähr, Viola Priesemann, Sebastian Kügler

Journal: Front Mol Neurosci

PubMed ID: 35721317

Doi: 10.3389/fnmol.2022.868790

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Rapid, sensitive, and low-cost detection of Escherichia coli bacteria in contaminated water samples using a phage-based assay

Authors: Luis F Alonzo, Paras Jain, Troy Hinkley, Nick Clute-Reinig, Spencer Garing, Ethan Spencer, Van T T Dinh, David Bell, Sam Nugen, Kevin P Nichols, Anne-Laure M Le Ny

Journal: Sci Rep

PubMed ID: 35562180

Doi: 10.1038/s41598-022-11468-2

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An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

Authors: Lihong Liu, Sho Iketani, Yicheng Guo, Eswar R Reddem, Ryan G Casner, Manoj S Nair, Jian Yu, Jasper F-W Chan, Maple Wang, Gabriele Cerutti, Zhiteng Li, Nicholas C Morano, Candace D Castagna, Laura Corredor, Hin Chu, Shuofeng Yuan, Vincent Kwok-Man Poon, Chris Chun-Sing Chan, Zhiwei Chen, Yang Luo, Marcus Cunningham, Alejandro Chavez, Michael T Yin, David S Perlin, Moriya Tsuji, Kwok-Yung Yuen, Peter D Kwong, Zizhang Sheng, Yaoxing Huang, Lawrence Shapiro, David D Ho

Journal: Sci Transl Med

PubMed ID: 35438546

Doi: 10.1126/scitranslmed.abn6859

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Type B CTD Proteins Secreted by the Type IX Secretion System Associate with PorP-like Proteins for Cell Surface Anchorage

Authors: Dhana G Gorasia, Christine A Seers, Jacqueline E Heath, Michelle D Glew, Hamid Soleimaninejad, Catherine A Butler, Mark J McBride, Paul D Veith, Eric C Reynolds

Journal: Int J Mol Sci

PubMed ID: 35628493

Doi: 10.3390/ijms23105681

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Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens

Authors: Uddipan Kar, Sara Khaleeq, Priyanka Garg, Madhuraj Bhat, Poorvi Reddy, Venkada Subramanian Vignesh, Aditya Upadhyaya, Mili Das, Ghadiyaram Chakshusmathi, Suman Pandey, Somnath Dutta, Raghavan Varadarajan

Journal: Front Immunol

PubMed ID: 35720346

Doi: 10.3389/fimmu.2022.890622

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Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2

Authors: Juliana C Ferreira, Samar Fadl, Wael M Rabeh

Journal: J Biol Chem

PubMed ID: 35568197

Doi: 10.1016/j.jbc.2022.102023

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Transiently Transfected Mammalian Cell Cultures: An Adaptable and Effective Platform for Virus-like Particle-Based Vaccines against Foot-and-Mouth Disease Virus

Authors: Michael Puckette, Victoria Primavera, Erica Martel, Jose Barrera, William Hurtle, Benjamin Clark, Barbara Kamicker, Mariceny Zurita, David Brake, John Neilan

Journal: Viruses

PubMed ID: 35632734

Doi: 10.3390/v14050989

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Comparison of Four Systems for SARS-CoV-2 Antibody at Three Time Points after SARS-CoV-2 Vaccination

Authors: Jong Do Seo, Minjeong Nam, Tae Hwan Lee, Yeon-Sun Ahn, Seon-Hyeon Shin, Hye Young Han, Hee-Won Moon

Journal: Diagnostics (Basel)

PubMed ID: 35741159

Doi: 10.3390/diagnostics12061349

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Designing a novel E2-IFN-γ fusion protein against CSFV by immunoinformatics and structural vaccinology approaches

Authors: Yanmin Zhang, Weijian Zhang, Jun Cheng, Xuping Liu, Shiwei Miao, Wen-Song Tan, Liang Zhao

Journal: Appl Microbiol Biotechnol

PubMed ID: 35524776

Doi: 10.1007/s00253-022-11919-w

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AbSE Workflow: Rapid Identification of the Coding Sequence and Linear Epitope of the Monoclonal Antibody at the Single-cell Level

Authors: Lerong Ma, HongSheng Ouyang, Ang Su, Yuanzhu Zhang, Daxin Pang, Tao Zhang, Ruize Sun, Wentao Wang, Zicong Xie, Dongmei Lv

Journal: ACS Synth Biol

PubMed ID: 35503752

Doi: 10.1021/acssynbio.2c00018

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Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD

Authors: Tim Krischuns, Catherine Isel, Petra Drncova, Maria Lukarska, Alexander Pflug, Sylvain Paisant, Vincent Navratil, Stephen Cusack, Nadia Naffakh

Journal: PLoS Pathog

PubMed ID: 35605026

Doi: 10.1371/journal.ppat.1010328

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Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants

Authors: Yaning Li, Qing Fan, Bing Zhou, Yaping Shen, Yuanyuan Zhang, Lin Cheng, Furong Qi, Shuo Song, Yingying Guo, Renhong Yan, Bin Ju, Zheng Zhang

Journal: iScience

PubMed ID: 35607524

Doi: 10.1016/j.isci.2022.104431

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Epicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders

Authors: Elif Eroglu, Christopher Y T Yen, Yat-Long Tsoi, Nevin Witman, Ahmed Elewa, Alberto Joven Araus, Heng Wang, Tamara Szattler, Chimezie H Umeano, Jesper Sohlmér, Alexander Goedel, András Simon, Kenneth R Chien

Journal: Nat Cell Biol

PubMed ID: 35550612

Doi: 10.1038/s41556-022-00902-2

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Structure and Mechanism of a Cold-Adapted Bacterial Lipase

Authors: Florian van der Ent, Bjarte A Lund, Linn Svalberg, Miha Purg, Ghislean Chukwu, Mikael Widersten, Geir V Isaksen, Bjørn O Brandsdal, Johan Åqvist

Journal: Biochemistry

PubMed ID: 35503728

Doi: 10.1021/acs.biochem.2c00087

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Fermentative Indole Production via Bacterial Tryptophan Synthase Alpha Subunit and Plant Indole-3-Glycerol Phosphate Lyase Enzymes

Authors: Lenny Ferrer, Melanie Mindt, Maria Suarez-Diez, Tatjana Jilg, Maja Zagorščak, Jin-Ho Lee, Kristina Gruden, Volker F Wendisch, Katarina Cankar

Journal: J Agric Food Chem

PubMed ID: 35500281

Doi: 10.1021/acs.jafc.2c01042

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Quantitative proteomics of HFD-induced fatty liver uncovers novel transcription factors of lipid metabolism

Authors: Shang Zhi, Zhang Congcong, Gao Zhiling, Qian Yihan, Xin Yijing, Liu Guanjie, Wang Fang, Sun Xuehua, Li Hongjie, Kong Xiaoni, Gao Yueqiu

Journal: Int J Biol Sci

PubMed ID: 35637971

Doi: 10.7150/ijbs.71431

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Comparison of pathogenicity of different subgenotype porcine reproductive and respiratory syndrome viruses isolated in China

Authors: Jie Zhang, Juan Bai, Yangyang Sun, Xing Liu, Yanni Gao, Xianwei Wang, Yuanqi Yang, Ping Jiang

Journal: Microb Pathog

PubMed ID: 35640766

Doi: 10.1016/j.micpath.2022.105607

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Complex protein interactions mediate Drosophila Lar function in muscle tissue

Authors: Jessica Kawakami, David Brooks, Rana Zalmai, Steven D Hartson, Samuel Bouyain, Erika R Geisbrecht

Journal: PLoS ONE

PubMed ID: 35622884

Doi: 10.1371/journal.pone.0269037

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Sequestration of TDP-43 Aggregates by Cytoplasmic Expression of the proSAAS Chaperone

Authors: Juan R Peinado, Kriti Chaplot, Timothy S Jarvela, Edward M Barbieri, James Shorter, Iris Lindberg

Journal: ACS Chem Neurosci

PubMed ID: 35549000

Doi: 10.1021/acschemneuro.2c00156

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A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair

Authors: Susana Lechuga, Alexander X Cartagena-Rivera, Afshin Khan, Bert I Crawford, Vani Narayanan, Daniel E Conway, Jaakko Lehtimäki, Pekka Lappalainen, Florian Rieder, Michelle S Longworth, Andrei I Ivanov

Journal: FASEB J

PubMed ID: 35344227

Doi: 10.1096/fj.202200154R

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Humoral Immune Response Diversity to Different COVID-19 Vaccines: Implications for the "Green Pass" Policy

Authors: Immacolata Polvere, Alfredina Parrella, Lucrezia Zerillo, Serena Voccola, Gaetano Cardinale, Silvia D'Andrea, Jessica Raffaella Madera, Romania Stilo, Pasquale Vito, Tiziana Zotti

Journal: Front Immunol

PubMed ID: 35634315

Doi: 10.3389/fimmu.2022.833085

Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer

Authors: Tingjia Zhu, Yixuan Cen, Zhuoye Chen, Yanan Zhang, Lu Zhao, Jiaying Wang, Weiguo Lu, Xing Xie, Xinyu Wang

Journal: Cell Death Dis

PubMed ID: 35595754

Doi: 10.1038/s41419-022-04943-1

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Epitope-Based Vaccines against the Major Outer Membrane Protein Variable Domain 4 Elicit Protection in Mice

Authors: Amanda L Collar, Alexandria C Linville, Susan B Core, Kathryn M Frietze

Journal: Vaccines (Basel)

PubMed ID: 35746483

Doi: 10.3390/vaccines10060875

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Covalent Adduct Formation in Methylthio-d-ribose-1-phosphate Isomerase: Reaction Intermediate or Artifact?

Authors: Vamsee M Veeramachineni, Subashi T Ubayawardhana, Andrew S Murkin

Journal: Biochemistry

PubMed ID: 35580612

Doi: 10.1021/acs.biochem.2c00142

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CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids

Authors: Megan Lo, Amnon Sharir, Michael D Paul, Hayarpi Torosyan, Christopher Agnew, Amy Li, Cynthia Neben, Pauline Marangoni, Libin Xu, David R Raleigh, Natalia Jura, Ophir D Klein

Journal: Nat Commun

PubMed ID: 35504891

Doi: 10.1038/s41467-022-30186-x

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Coronavirus Disease 2019 Vaccine Booster Effects Are Seen in Human Milk Antibody Response

Authors: Jeffrey M Bender, Yesun Lee, Wesley A Cheng, Carolyn J Marentes Ruiz, Pia S Pannaraj

Journal: Front Nutr

PubMed ID: 35685893

Doi: 10.3389/fnut.2022.898849

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The key sulfometuron-methyl degrading bacteria isolation based on soil bacterial phylogenetic molecular ecological networks and application for bioremediation of contaminated soil by immobilization

Authors: Hao Zhang, Chun-Yang Liu, Xin Zhang, Hui-Ying Yang, Jie Sun, Cheng-Bin Liu, Na Li

Journal: Ecotoxicol Environ Saf

PubMed ID: 35561546

Doi: 10.1016/j.ecoenv.2022.113605

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Identification of RBMX as a splicing regulator in Parkinsonian mimetic induced alternative splicing of α-synuclein

Authors: Swaroop Thonda, Ravali L Vinnakota, Swathi V Kona, Shasi V Kalivendi

Journal: Biochim Biophys Acta Gene Regul Mech

PubMed ID: 35577270

Doi: 10.1016/j.bbagrm.2022.194825

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Enhancing fluxes through the mevalonate pathway in Saccharomyces cerevisiae by engineering the HMGR and β-alanine metabolism

Authors: Surui Lu, Chenyao Zhou, Xuena Guo, Zhengda Du, Yanfei Cheng, Zhaoyue Wang, Xiuping He

Journal: Microb Biotechnol

PubMed ID: 35531990

Doi: 10.1111/1751-7915.14072

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Smartly responsive DNA-miRNA hybrids packaged in exosomes for synergistic enhancement of cancer cell apoptosis

Authors: Fan Zhang, Albertina N Isak, Shiqi Yang, Yuchen Song, Lingjie Ren, Chang Feng, Guifang Chen

Journal: Nanoscale

PubMed ID: 35421879

Doi: 10.1039/d1nr08539e

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Glutathione S-transferase: a candidate gene for berry color in muscadine grapes (Vitis rotundifolia)

Authors: Aruna Varanasi, Margaret Worthington, Lacy Nelson, Autumn Brown, Thomas Mason Chizk, Renee Threlfall, Luke Howard, Patrick Conner, Rosa Figueroa-Balderas, Mélanie Massonnet, Dario Cantu, John R Clark

Journal: G3 (Bethesda)

PubMed ID: 35302606

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Crosstalk between IL-15Rα tumor-associated macrophages and breast cancer cells reduces CD8 T cell recruitment

Authors: Wenlong Zhang, Qing Zhang, Nanfei Yang, Qian Shi, Huifang Su, Tingsheng Lin, Zhonglei He, Wenxin Wang, Hongqian Guo, Pingping Shen

Journal: Cancer Commun (Lond)

PubMed ID: 35615815

Doi: 10.1002/cac2.12311

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A Novel Ig Domain-Containing C-Type Lectin Triggers the Intestine-Hemocyte Axis to Regulate Antibacterial Immunity in Crab

Authors: Kaimin Zhou, Yukai Qin, Yu Song, Ke Zhao, Weijuan Pan, Xingyu Nan, Yue Wang, Qun Wang, Weiwei Li

Journal: J Immunol

PubMed ID: 35508356

Doi: 10.4049/jimmunol.2101027

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Self-Assembling Nanovaccine Confers Complete Protection Against Zika Virus Without Causing Antibody-Dependent Enhancement

Authors: Heng Rong, Mi Qi, Jingdi Pan, Yuhan Sun, Jiawang Gao, Xiaowei Zhang, Wei Li, Bo Zhang, Xian-En Zhang, Zongqiang Cui

Journal: Front Immunol

PubMed ID: 35615356

Doi: 10.3389/fimmu.2022.905431

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Structural basis of sodium-dependent bile salt uptake into the liver

Authors: Kapil Goutam, Francesco S Ielasi, Els Pardon, Jan Steyaert, Nicolas Reyes

Journal: Nature

PubMed ID: 35545671

Doi: 10.1038/s41586-022-04723-z

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Duo Cadherin-Functionalized Microparticles Synergistically Induce Chondrogenesis and Cartilage Repair of Stem Cell Aggregates

Authors: Xueping Wang, Xingquan Xu, Yan Zhang, Xueying An, Xue Zhang, Guoqiang Chen, Qing Jiang, Jun Yang

Journal: Adv Healthc Mater

PubMed ID: 35485302

Doi: 10.1002/adhm.202200246

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Revisiting misfolding propensity of serum amyloid A1: Special focus on the signal peptide region

Authors: Morgan S Haines, Eduardo Ramirez, Kendall B E Moore, Jessica S Fortin

Journal: Biochem Biophys Rep

PubMed ID: 35664543

Doi: 10.1016/j.bbrep.2022.101284

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Antibodies targeting the European lobster (Palinurus elephas) vitellogenin developed by mRNA isolation and in-silico-designed antigenic peptides

Authors: Faustina B Cannea, Maria Cristina Follesa, Cristina Porcu, Rossano Rossino, Alessandra Olianas, Antonio Rescigno, Alessandra Padiglia

Journal: Biol Open

PubMed ID: 35452506

Doi: 10.1242/bio.059019

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Small, charged proteins in salmon louse (Lepeophtheirus salmonis) secretions modulate Atlantic salmon (Salmo salar) immune responses and coagulation

Authors: Aina-Cathrine Øvergård, Helena M D Midtbø, Lars A Hamre, Michael Dondrup, Gro E K Bjerga, Øivind Larsen, Jiwan Kumar Chettri, Kurt Buchmann, Frank Nilsen, Sindre Grotmol

Journal: Sci Rep

PubMed ID: 35568726

Doi: 10.1038/s41598-022-11773-w

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Functional validation of a novel AAAS variant in an atypical presentation of Allgrove syndrome

Authors: Erica L Macke, Joel A Morales-Rosado, Sarah K Macklin-Mantia, Christopher T Schmitz, Björn Oskarsson, Eric W Klee, Klaas J Wierenga

Journal: Mol Genet Genomic Med

PubMed ID: 35570467

Doi: 10.1002/mgg3.1966

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SARS-CoV-2 BA1 variant is neutralized by vaccine booster-elicited serum but evades most convalescent serum and therapeutic antibodies

Authors: Sabrina Lusvarghi, Simon D Pollett, Sabari Nath Neerukonda, Wei Wang, Richard Wang, Russell Vassell, Nusrat J Epsi, Anthony C Fries, Brian K Agan, David A Lindholm, Christopher J Colombo, Rupal Mody, Evan C Ewers, Tahaniyat Lalani, Anuradha Ganesan, Emilie Goguet, Monique Hollis-Perry, Si'Ana A Coggins, Mark P Simons, Leah C Katzelnick, Gregory Wang, David R Tribble, Lisa Bentley, Ann E Eakin, Christopher C Broder, Karl J Erlandson, Eric D Laing, Timothy H Burgess, Edward Mitre, Carol D Weiss

Journal: Sci Transl Med

PubMed ID: 35380448

Doi: 10.1126/scitranslmed.abn8543

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Lactoferrin Inhibition of the Complex Formation between ACE2 Receptor and SARS CoV-2 Recognition Binding Domain

Authors: Roberta Piacentini, Laura Centi, Mattia Miotto, Edoardo Milanetti, Lorenzo Di Rienzo, Martina Pitea, Paolo Piazza, Giancarlo Ruocco, Alberto Boffi, Giacomo Parisi

Journal: Int J Mol Sci

PubMed ID: 35628247

Doi: 10.3390/ijms23105436

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Computational approach for binding prediction of SARS-CoV-2 with neutralizing antibodies

Authors: Daria Beshnova, Yan Fang, Mingjian Du, Yehui Sun, Fenghe Du, Jianfeng Ye, Zhijian James Chen, Bo Li

Journal: Comput Struct Biotechnol J

PubMed ID: 35530743

Doi: 10.1016/j.csbj.2022.04.038

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α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins

Authors: Weidong Jing, Jordan Lo Pilato, Callum Kay, Shouya Feng, Daniel Enosi Tuipulotu, Anukriti Mathur, Cheng Shen, Chinh Ngo, Anyang Zhao, Lisa A Miosge, Sidra A Ali, Elizabeth E Gardiner, Milena M Awad, Dena Lyras, Avril A B Robertson, Nadeem O Kaakoush, Si Ming Man

Journal: Sci Immunol

PubMed ID: 35594341

Doi: 10.1126/sciimmunol.abm1803

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An Immunoinformatic Strategy to Develop New Multi-epitope Vaccine

Authors:

Journal: INT J PEPT RES THER

PubMed ID: 35573911

Doi: 10.1007/s10989-022-10406-0

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Constitutively Active STAT5b Feminizes Mouse Liver Gene Expression

Authors: Dana Lau-Corona, Hong Ma, Cameron Vergato, Andre Sarmento-Cabral, Mercedes Del Rio-Moreno, Rhonda D Kineman, David J Waxman

Journal: Endocrinology

PubMed ID: 35396838

Doi: 10.1210/endocr/bqac046

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Characterization of a New Multifunctional GH20 β--Acetylglucosaminidase From sp GC72 and Its Application in Converting Chitin Into Acetyl Glucosamine

Authors: Yan Chen, Ning Zhou, Xueman Chen, Guoguang Wei, Alei Zhang, Kequan Chen, Pingkai Ouyang

Journal: Front Microbiol

PubMed ID: 35620090

Doi: 10.3389/fmicb.2022.874908

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Lentiviral gene therapy prevents anti-human acid α-glucosidase antibody formation in murine Pompe disease

Authors: Qiushi Liang, Eva C Vlaar, Fabio Catalano, Joon M Pijnenburg, Merel Stok, Yvette van Helsdingen, Arnold G Vulto, Wendy W J Unger, Ans T van der Ploeg, W W M Pim Pijnappel, Niek P van Til

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35662813

Doi: 10.1016/j.omtm.2022.04.016

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Biosynthesis of valerenic acid by engineered Saccharomyces cerevisiae

Authors: Mengya Zhao, Chuanbo Zhang, Haibin Wang, Shifan He, Wenyu Lu

Journal: Biotechnol Lett

PubMed ID: 35643816

Doi: 10.1007/s10529-022-03264-9

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A proof-of-concept study on the use of a fluorescein-based 18F-tracer for pretargeted PET

Authors: Hugo Helbert , Emily M Ploeg , Douwe F Samplonius , Simon N Blok , Ines F Antunes , Verena I Böhmer , Gert Luurtsema , Rudi A J O Dierckx , Ben L Feringa , Philip H Elsinga , Wiktor Szymanski , Wijnand Helfrich

Journal: EJNMMI Radiopharm Chem .

PubMed ID: 35239034

Doi: 10.1186/s41181-022-00155-2

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Cell-Penetrating Peptide TAT-HuR-HNS3 Suppresses Proinflammatory Gene Expression via Competitively Blocking Interaction of HuR with Its Partners

Authors: Ke Wang, Haibin Tong, Yitian Gao, Lan Xia, Xin Jin, Xiaoxue Li, Xianlu Zeng, Istvan Boldogh, Yueshuang Ke, Xueqing Ba

Journal: J Immunol

PubMed ID: 35444028

Doi: 10.4049/jimmunol.2200002

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Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast

Authors: Tengfei Liu , Yuanwei Gou , Bei Zhang , Rui Gao , Chang Dong , Mingming Qi , Lihong Jiang , Xuanwei Ding , Chun Li , Jiazhang Lian

Journal: Biotechnol Bioeng

PubMed ID: 35060115

Doi: doi.org/10.1002/bit.28040

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Thioester-Assisted Sortase-A - Mediated Ligation

Authors: Chong Zuo 1, Ruichao Ding 1, Xiangwei Wu , Yuanxia Wang , Guo-Chao Chu, Lu-Jun Liang, Huasong Ai ， Ze-Bin Tong , Junxiong Mao , Qingyun Zheng , Tian Wang , Zichen Li , Lei Liu, Demeng Sun

Journal: Angew Chem Int Ed Engl

PubMed ID: 35514243

Doi: 10.1002/anie.202201887

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An Arabidopsis pre-RNA processing8a (prp8a) missense allele restores splicing of a subset of mis-spliced mRNAs

Authors: Roxanna J Llinas , Jia Qi Xiong , Natalie M Clark , Sarah E Burkhart , Bonnie Bartel

Journal: Plant Physiol

PubMed ID: 35608297

Doi: 10.1093/plphys/kiac221

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Adaptation-Proof SARS-CoV-2 Vaccine Design

Authors: Yashavantha L Vishweshwaraiah, Brianna Hnath, Brendan Rackley, Jian Wang, Abhinay Gontu, Morgan Chandler, Kirill A Afonin, Suresh V Kuchipudi, Neil Christensen, Neela H Yennawar, Nikolay V Dokholyan

Journal: biorxiv

PubMed ID: 35611332

Doi: doi.org/10.1002/adfm.202206055

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Effective-Component Compatibility of Bufei Yishen Formula III Combined with Electroacupuncture Suppresses Inflammatory Response in Rats with Chronic Obstructive Pulmonary Disease via Regulating SIRT1/NF-B Signaling

Authors: Fanli Jin, Lanxi Zhang, Kai Chen, Yufang Miao, Yang Liu, Yange Tian, Jiansheng Li

Journal: Biomed Res Int

PubMed ID: 35586807

Doi: 10.1155/2022/3360771

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Identification and Functional Characterization of Peptides With Antimicrobial Activity From the Syphilis Spirochete,

Authors: Simon Houston, Ethan Schovanek, Kate M E Conway, Sarah Mustafa, Alloysius Gomez, Raghavendran Ramaswamy, Ayman Haimour, Martin J Boulanger, Lisa A Reynolds, Caroline E Cameron

Journal: Front Microbiol

PubMed ID: 35722306

Doi: 10.3389/fmicb.2022.888525

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3,5,3'-Triiodothyronine-Loaded Liposomes Inhibit Hepatocarcinogenesis Inflammation-Associated Macrophages

Authors: Gangqi Sun, Xiaojuan Hou, Luyao Zhang, Hengyan Zhang, Changchun Shao, Fengwei Li, Chen Zong, Rong Li, Junxia Shi, Xue Yang, Li Zhang

Journal: Front Oncol

PubMed ID: 35646705

Doi: 10.3389/fonc.2022.877982

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