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AlphaFold version 20 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys-Cys) formation of functional significance for VIPR2

Authors: Kotaro Sakamoto, Satoshi Asano, Yukio Ago, Takatsugu Hirokawa

Journal: Biochem Biophys Res Commun

PubMed ID: 36332470

Doi: 10.1016/j.bbrc.2022.10.071

Products & Services: Plasmid DNA Preparation

Presence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies Among Vietnamese Healthcare Workers by Dosing Interval for ChAdOx1 nCoV-19 Vaccine

Authors: Dien M Vu, Diep T B Vu, Thuy T T Do, Allison E Olmsted, Bach H Dao, Truc T Thai, Chi L Nguyen, Nhung T T Le, Tuan A Le, Hien T T Bui, Thach N Pham, Matthew R Moore

Journal: Clin Infect Dis

PubMed ID: 35723271

Doi: 10.1093/cid/ciac493

Products & Services: Recombinant Proteins

Systemic and Mucosal Humoral Immune Response Induced by Three Doses of the BNT162b2 SARS-CoV-2 mRNA Vaccines

Authors: Roberta Mancuso, Simone Agostini, Lorenzo Agostino Citterio, Debora Chiarini, Maria Antonia Santangelo, Mario Clerici

Journal: Vaccines (Basel)

PubMed ID: 36298514

Doi: 10.3390/vaccines10101649

Products & Services: Serology SARS-Cov-2 detection kits

A pseudovirus-based platform to measure neutralizing antibodies in Mexico using SARS-CoV-2 as proof-of-concept

Authors: José Antonio Cruz-Cardenas, Michelle Gutierrez, Alejandra López-Arredondo, Julio Enrique Castañeda-Delgado, Augusto Rojas-Martinez, Yukio Nakamura, José Antonio Enciso-Moreno, Laura A Palomares, Marion E G Brunck

Journal: Sci Rep

PubMed ID: 36289285

Doi: 10.1038/s41598-022-22921-7

Pathobiology and dysbiosis of the respiratory and intestinal microbiota in 14 months old Golden Syrian hamsters infected with SARS-CoV-2

Authors: Brittany Seibert, C Joaquín Cáceres, Silvia Carnaccini, Stivalis Cardenas-Garcia, L Claire Gay, Lucia Ortiz, Ginger Geiger, Daniela S Rajao, Elizabeth Ottesen, Daniel R Perez

Journal: PLoS Pathog

PubMed ID: 36279276

Doi: 10.1371/journal.ppat.1010734

Products & Services: Recombinant Proteins

A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding

Authors: Shanelle Shillingford, Lei Zhang, Yulia Surovtseva, Sam Dorry, Elias Lolis, Anton M Bennett

Journal: J Biol Chem

PubMed ID: 36272649

Doi: 10.1016/j.jbc.2022.102617

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SCF regulates G2-M progression through control of CCNL1 ubiquitination

Authors: Siobhan O'Brien, Susan Kelso, Zachary Steinhart, Stephen Orlicky, Monika Mis, Yunhye Kim, Sichun Lin, Frank Sicheri, Stephane Angers

Journal: EMBO Rep

PubMed ID: 36278408

Doi: 10.15252/embr.202255044

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Rat Group IIA Secreted Phospholipase A Binds to Cytochrome c Oxidase and Inhibits Its Activity: A Possible Episode in the Development of Alzheimer's Disease

Authors: Adrijan Ivanušec, Jernej Šribar, Adrijana Leonardi, Maja Zorović, Marko Živin, Igor Križaj

Journal: Int J Mol Sci

PubMed ID: 36293221

Doi: 10.3390/ijms232012368

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CD4 T cell epitope abundance in ferritin core potentiates responses to hemagglutinin nanoparticle vaccines

Authors: Sean A Nelson, Katherine A Richards, Maryah A Glover, Francisco A Chaves, Michelle C Crank, Barney S Graham, Masaru Kanekiyo, Andrea J Sant

Journal: npj Vaccines

PubMed ID: 36289232

Doi: 10.1038/s41541-022-00547-0

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Structure of the core human NADPH oxidase NOX2

Authors: Sigrid Noreng, Naruhisa Ota, Yonglian Sun, Hoangdung Ho, Matthew Johnson, Christopher P Arthur, Kellen Schneider, Isabelle Lehoux, Christopher W Davies, Kyle Mortara, Kit Wong, Dhaya Seshasayee, Matthieu Masureel, Jian Payandeh, Tangsheng Yi, James T Koerber

Journal: Nat Commun

PubMed ID: 36241643

Doi: 10.1038/s41467-022-33711-0

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Sorting nexin-dependent therapeutic targeting of oncogenic epidermal growth factor receptor

Authors: Benjamin Atwell, Cheng-Yu Chen, Matthew Christofferson, William R Montfort, Joyce Schroeder

Journal: Cancer Gene Ther

PubMed ID: 36253541

Doi: 10.1038/s41417-022-00541-7

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Target RNA activates the protease activity of Craspase to confer antiviral defense

Authors: Xi Liu, Laixing Zhang, Hao Wang, Yu Xiu, Ling Huang, Zhengyu Gao, Ningning Li, Feixue Li, Weijia Xiong, Teng Gao, Yi Zhang, Maojun Yang, Yue Feng

Journal: Mol Cell

PubMed ID: 36306795

Doi: 10.1016/j.molcel.2022.10.007

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Deciphering the virulence potential of Listeria monocytogenes in the Norwegian meat and salmon processing industry by combining whole genome sequencing and in vitro data

Authors: Eva Wagner, Annette Fagerlund, Sarah Thalguter, Merete Rusås Jensen, Even Heir, Trond Møretrø, Birgitte Moen, Solveig Langsrud, Kathrin Rychli

Journal: Int J Food Microbiol

PubMed ID: 36240603

Doi: 10.1016/j.ijfoodmicro.2022.109962

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Prostaglandin E synchronizes lunar-regulated beach spawning in grass puffers

Authors: Junfeng Chen, Yuma Katada, Kousuke Okimura, Taiki Yamaguchi, Ying-Jey Guh, Tomoya Nakayama, Michiyo Maruyama, Yuko Furukawa, Yusuke Nakane, Naoyuki Yamamoto, Yoshikatsu Sato, Hironori Ando, Asako Sugimura, Kazufumi Tabata, Ayato Sato, Takashi Yoshimura

Journal: Curr Biol

PubMed ID: 36306789

Doi: 10.1016/j.cub.2022.09.062

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Proline-Rich Region II (PRR2) Plays an Important Role in Tau-Glycan Interaction: An NMR Study

Authors: Anqesha Murray, Lufeng Yan, James M Gibson, Jian Liu, David Eliezer, Guy Lippens, Fuming Zhang, Robert J Linhardt, Jing Zhao, Chunyu Wang

Journal: Biomolecules

PubMed ID: 36358923

Doi: 10.3390/biom12111573

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Durability of antibodies post vaccination with two doses of inactivated BBIBP-CorV vaccine

Authors: Sally Mahmoud, Subhashini Ganesan, Narjes Saheb Sharif-Askari, Flavia Cantarutti, Hannah Wilson, Pauline Ogrodzki, Rabih Halwani, Nawal Alkaabi, Walid Abbas Zaher

Journal: Curr Med Res Opin

PubMed ID: 36274640

Doi: 10.1080/03007995.2022.2139969

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The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation

Authors: Radwa E Mahgoub, Feda E Mohamed, Lara Alzyoud, Bassam R Ali, Juliana Ferreira, Wael M Rabeh, Shaikha S AlNeyadi, Noor Atatreh, Mohammad A Ghattas

Journal: Molecules

PubMed ID: 36235244

Doi: 10.3390/molecules27196710

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Quantum Dot-Based Screening Identifies F3 Peptide and Reveals Cell Surface Nucleolin as a Therapeutic Target for Rhabdomyosarcoma

Authors: Dzhangar Dzhumashev, Andrea Timpanaro, Safa Ali, Andrea J De Micheli, Kamel Mamchaoui, Ilaria Cascone, Jochen Rössler, Michele Bernasconi

Journal: Cancers (Basel)

PubMed ID: 36291832

Doi: 10.3390/cancers14205048

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Establishment of a protocol for preventive vaccination against equine insect bite hypersensitivity

Authors: Sara Bjork Stefansdottir, Sigridur Jonsdottir, Holmfridur Kristjansdottir, Vilhjalmur Svansson, Eliane Marti, Sigurbjorg Torsteinsdottir

Journal: Vet Immunol Immunopathol

PubMed ID: 36272211

Doi: 10.1016/j.vetimm.2022.110502

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Development and in vitro characterization of a humanized scFv against fungal infections

Authors: Tomas Di Mambro, Tania Vanzolini, Marzia Bianchi, Rita Crinelli, Barbara Canonico, Filippo Tasini, Michele Menotta, Mauro Magnani

Journal: PLoS ONE

PubMed ID: 36315567

Doi: 10.1371/journal.pone.0276786

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PCDetection: PolyA-CRISPR/Cas12a-based miRNA detection without PAM restriction

Authors: Mingtian Zhong , Kaizhao Chen , Wenjun Sun , Xiangyang Li , Shisheng Huang , Qingzhou Meng , Bo Sun , Xingxu Huang , Xinjie Wang , Xiaodong Ma , Peixiang Ma

Journal: Biosens Bioelectron

PubMed ID: 35797934

Doi: 10.1016/j.bios.2022.114497

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A switchable Cas12a enabling CRISPR-based direct histone deacetylase activity detection

Authors: Wenyuan Kang , Lin Liu , Peihang Yu , Tianyi Zhang , Chunyang Lei , Zhou Nie

Journal: Biosens Bioelectron

PubMed ID: 35700604

Doi: doi.org/10.1016/j.bios.2022.114468

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Asymmetric Stratification-Induced Polarity Loss and Coordinated Individual Cell Movements Drive Directional Migration of Vertebrate Epithelium

Authors: Yunzhe Lu , Ruolan Deng , Huanyang You , Yishu Xu , Christopher Antos , Jianlong Sun , Ophir D Klein , Pengfei Lu

Journal: Cell Rep

PubMed ID: 33053348

Doi: 10.1016/j.celrep.2020.108246

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Epstein-Barr Virus Tegument Protein BKRF4 is a Histone Chaperone

Authors: Yongrui Liu , Yue Li , Hongyu Bao , Yanhong Liu , Liu Chen , Hongda Huang

Journal: J Mol Biol

PubMed ID: 35870648

Doi: 10.1016/j.jmb.2022.167756

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De novo design of anti-tuberculosis agents using a structure-based deep learning method

Authors: Sowmya Ramaswamy Krishnan, Navneet Bung, Siladitya Padhi, Gopalakrishnan Bulusu, Parimal Misra, Manojit Pal, Srinivas Oruganti, Rajgopal Srinivasan, Arijit Roy

Journal: J Mol Graph Model

PubMed ID: 36257148

Doi: 10.1016/j.jmgm.2022.108361

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Isobutanol production by combined and metabolic engineering

Authors: Mamta Gupta, Matthew Wong, Kamran Jawed, Kamil Gedeon, Hannah Barrett, Marcelo Bassalo, Clifford Morrison, Danish Eqbal, Syed Shams Yazdani, Ryan T Gill, Jiaqi Huang, Marc Douaisi, Jonathan Dordick, Georges Belfort, Mattheos A G Koffas

Journal: Metab Eng Commun

PubMed ID: 36325486

Doi: 10.1016/j.mec.2022.e00210

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The large plasmid carried class 1 integrons mediated multidrug resistance of foodborne Indiana

Authors: Xuefeng Wang, Tian Wang, Mengjiao Guo, Chengcheng Zhang, Zongyi Bo, Yantao Wu, Guoxiang Chao

Journal: Front Microbiol

PubMed ID: 36312970

Doi: 10.3389/fmicb.2022.991326

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Multifunctional chemical inhibitors of the florigen activation complex discovered by structure-based high-throughput screening

Authors: Ken-Ichiro Taoka, Ikumi Kawahara, Shoko Shinya, Ken-Ichi Harada, Eiki Yamashita, Zenpei Shimatani, Kyoko Furuita, Tomoaki Muranaka, Tokitaka Oyama, Rie Terada, Atsushi Nakagawa, Toshimichi Fujiwara, Hiroyuki Tsuji, Chojiro Kojima

Journal: Plant J

PubMed ID: 36288411

Doi: 10.1111/tpj.16008

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Development and characterization of a new monoclonal antibody against SARS-CoV-2 NSP12 (RdRp)

Authors: Wen Meng, Siying Guo, Simon Cao, Masahiro Shuda, Lindsey R Robinson-McCarthy, Kevin R McCarthy, Yoko Shuda, Alberto E Paniz Mondolfi, Clare Bryce, Zachary Grimes, Emilia M Sordillo, Carlos Cordon-Cardo, Pengfei Li, Hu Zhang, Stanley Perlman, Haitao Guo, Shou-Jiang Gao, Yuan Chang, Patrick S Moore

Journal: J Med Virol

PubMed ID: 36271490

Doi: 10.1002/jmv.28246

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A simple thermodynamic description of phase separation of Nup98 FG domains

Authors: Sheung Chun Ng, Dirk Görlich

Journal: Nat Commun

PubMed ID: 36257947

Doi: 10.1038/s41467-022-33697-9

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A novel rhesus macaque model of Huntington's disease recapitulates key neuropathological changes along with motor and cognitive decline

Authors: Alison R Weiss, William A Liguore, Kristin Brandon, Xiaojie Wang, Zheng Liu, Jacqueline S Domire, Dana Button, Sathya Srinivasan, Christopher D Kroenke, Jodi L McBride

Journal: Elife

PubMed ID: 36205397

Doi: 10.7554/eLife.77568

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Comparative proteomic analysis reveals novel insights into the continuous cropping induced response in Scrophularia ningpoensis

Authors: Jiachen Sun, Xuejiao Li, Zhuo Qu, Huairui Wang, Yao Cheng, Shengjie Dong, Hui Zhao

Journal: J Sci Food Agric

PubMed ID: 36271763

Doi: 10.1002/jsfa.12284

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Sex Difference Leads to Differential Gene Expression Patterns and Therapeutic Efficacy in Mucopolysaccharidosis IVA Murine Model Receiving AAV8 Gene Therapy

Authors: Matthew Piechnik, Paige C Amendum, Kazuki Sawamoto, Molly Stapleton, Shaukat Khan, Nidhi Fnu, Victor Álvarez, Angelica Maria Herreño Pachon, Olivier Danos, Joseph T Bruder, Subha Karumuthil-Melethil, Shunji Tomatsu

Journal: Int J Mol Sci

PubMed ID: 36293546

Doi: 10.3390/ijms232012693

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External quality assessment of SARS-CoV-2 serology in European expert laboratories, April 2021

Authors: Ramona Mögling, Francesca Colavita, Johan Reimerink, Angeliki Melidou, Katrin Leitmeyer, Maria Keramarou, Daniele Lapa, Massimo Francalancia, Jean-Luc Murk, Ann Vossen, Fabrizio Carletti, Boris Hogema, Adam Meijer, Liesbet Deprez, Antonino di Caro, Concetta Castilletti, Chantal Bem Reusken

Journal: Euro Surveill

PubMed ID: 36268736

Doi: 10.2807/1560-7917.ES.2022.27.42.2101057

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Upregulation of programmed cell death 1 by interferon gamma and its biological functions in human monocytes

Authors: Kittitach Sri-Ngern-Ngam, Pornlapat Keawvilai, Trairak Pisitkun, Tanapat Palaga

Journal: Biochem Biophys Rep

PubMed ID: 36275930

Doi: 10.1016/j.bbrep.2022.101369

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Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage

Authors: Qianying Lv, Xinli Han, Jiajia Ni, Qianqian Ma, Rufeng Dai, Jiaojiao Liu, Jialu Liu, Yihui Zhai, Qian Shen, Li Sun, Haimei Liu, Jia Rao, Hong Xu

Journal: Cell Death Dis

PubMed ID: 36229446

Doi: 10.1038/s41419-022-05313-7

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On the role of cell surface associated, mucin-like glycoproteins in the pennate diatom Craspedostauros australis (Bacillariophyceae)

Authors: Nicole Poulsen, Helene Hennig, Veikko F Geyer, Stefan Diez, Richard Wetherbee, Sorel Fitz-Gibbon, Matteo Pellegrini, Nils Kröger

Journal: J Phycol

PubMed ID: 36199194

Doi: 10.1111/jpy.13287

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A critical path to producing high quality, reproducible data from quantitative western blot experiments

Authors: Sean C Taylor, Luciana K Rosselli-Murai, Bélinda Crobeddu, Isabelle Plante

Journal: Sci Rep

PubMed ID: 36266411

Doi: 10.1038/s41598-022-22294-x

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Transient State Kinetics of Apicoplast DNA Polymerase Suggests the Involvement of Accessory Factors for Efficient and Accurate DNA Synthesis

Authors: Anamika Kumari, Anjali Yadav, Indrajit Lahiri

Journal: Biochemistry

PubMed ID: 36251801

Doi: 10.1021/acs.biochem.2c00446

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A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction

Authors: John T Happ, Corvin D Arveseth, Jessica Bruystens, Daniela Bertinetti, Isaac B Nelson, Cristina Olivieri, Jingyi Zhang, Danielle S Hedeen, Ju-Fen Zhu, Jacob L Capener, Jan W Bröckel, Lily Vu, C C King, Victor L Ruiz-Perez, Xuecai Ge, Gianluigi Veglia, Friedrich W Herberg, Susan S Taylor, Benjamin R Myers

Journal: Nat Struct Mol Biol

PubMed ID: 36202993

Doi: 10.1038/s41594-022-00838-z

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Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation

Authors: Wen-Hsin Lee, Xiaorui Chen, I-Ju Liu, Jiin-Horng Lee, Chun-Mei Hu, Han-Chung Wu, Sheng-Kai Wang, Wen-Hwa Lee, Che Ma

Journal: Cell Rep

PubMed ID: 36288706

Doi: 10.1016/j.celrep.2022.111555

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Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity

Authors: Brett H Pogostin, Marina H Yu, Alon R Azares, Erin M Euliano, Cheuk Sun Edwin Lai, Gabriel Saenz, Samuel X Wu, Adam C Farsheed, Sarah M Melhorn, Tyler P Graf, Darren G Woodside, Jeffrey D Hartgerink, Kevin J McHugh

Journal: Biomater Sci

PubMed ID: 36102692

Doi: 10.1039/d2bm01242a

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Evasion of cGAS and TRIM5 defines pandemic HIV

Authors: Lorena Zuliani-Alvarez, Morten L Govasli, Jane Rasaiyaah, Chris Monit, Stephen O Perry, Rebecca P Sumner, Simon McAlpine-Scott, Claire Dickson, K M Rifat Faysal, Laura Hilditch, Richard J Miles, Frederic Bibollet-Ruche, Beatrice H Hahn, Till Boecking, Nikos Pinotsis, Leo C James, David A Jacques, Greg J Towers

Journal: Nat Microbiol

PubMed ID: 36289397

Doi: 10.1038/s41564-022-01247-0

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DNA damage-induced nuclear import of HSP90α is promoted by Aha1

Authors: Nupur Fangaria, Khushboo Rani, Priyanka Singh, Sandeep Dey, Kota Arun Kumar, Sunanda Bhattacharyya

Journal: Mol Biol Cell

PubMed ID: 36260391

Doi: 10.1091/mbc.E21-11-0554

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Identification of human MHC-I HPV18 E6/E7-specific CD8 + T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice

Authors: Shiwen Peng, Deyin Xing, Louise Ferrall, Ya-Chea Tsai, Chien-Fu Hung, T-C Wu

Journal: J Biomed Sci

PubMed ID: 36224625

Doi: 10.1186/s12929-022-00864-5

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Fructose-6-phosphate-2-kinase/fructose-2,6-bisphosphatase regulates energy metabolism and synthesis of storage products in developing rice endosperm

Authors: Xiaoli Chen , Yi Ji , Weiying Zhao , Huanying Niu , Xue Yang , Xiaokang Jiang , Yipeng Zhang , Jie Lei , Hang Yang , Rongbo Chen , Chuanwei Gu , Hongyi Xu , Hui Dong , Erchao Duan , Xuan Teng , Yunlong Wang , Yuanyan Zhang , Wenwei Zhang , Yihua Wang , Jianmin Wan

Journal: Plant Sci

PubMed ID: 36270512

Doi: 10.1016/j.plantsci.2022.111503

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The Detection of Immunity against WT1 and SMAD4 of EpCAM Cancer Cells in Malignant Pleural Effusion

Authors: Terutsugu Koya, Yo Niida, Misa Togi, Kenichi Yoshida, Takuya Sakamoto, Hiroki Ura, Sumihito Togi, Tomohisa Kato, Sohsuke Yamada, Haruo Sugiyama, Shigeo Koido, Shigetaka Shimodaira

Journal: Int J Mol Sci

PubMed ID: 36293034

Doi: 10.3390/ijms232012177

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Discovery and functional characterization of the oncogenicity and targetability of a novel gene fusion in pediatric angiosarcoma

Authors: Payal Jain, Sudarshan Iyer, Joshua Straka, Lea F Surrey, Jennifer Pogoriler, Harry Han, Tiffany Smith, Christine Busch, Elizabeth Fox, Marilyn Li, Angela J Waanders, Adam Resnick, Monika A Davare

Journal: Cold Spring Harb Mol Case Stud

PubMed ID: 36307212

Doi: 10.1101/mcs.a006222

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A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers

Authors: Rongjie Cheng, Fanying Li, Maolei Zhang, Xin Xia, Jianzhuang Wu, Xinya Gao, Huangkai Zhou, Zhi Zhang, Nunu Huang, Xuesong Yang, Yaliang Zhang, Shunli Shen, Tiebang Kang, Zexian Liu, Feizhe Xiao, Hongwei Yao, Jianbo Xu, Chao Yan, Nu Zhang

Journal: Cell Res

PubMed ID: 36241718

Doi: 10.1038/s41422-022-00726-7

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A dataset comprised of binding interactions for 104,972 antibodies against a SARS-CoV-2 peptide

Authors: Emily Engelhart, Ryan Emerson, Leslie Shing, Chelsea Lennartz, Daniel Guion, Mary Kelley, Charles Lin, Randolph Lopez, David Younger, Matthew E Walsh

Journal: Sci Data

PubMed ID: 36289234

Doi: 10.1038/s41597-022-01779-4

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Autophagic flux restoration enhances the antitumor efficacy of tumor infiltrating lymphocytes

Authors: Chaoting Zhang, Yizhe Sun, Shance Li, Luyan Shen, Xia Teng, Yefei Xiao, Nan Wu, Zheming Lu

Journal: J Immunother Cancer

PubMed ID: 36307150

Doi: 10.1136/jitc-2022-004868

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ICG-Dimeric Her2-Specific Affibody Conjugates for Tumor Imaging and Photothermal Therapy for Her2-Positive Tumors

Authors: Dianlong Jia, Huimin Liu, Shuhui Zheng, Dandan Yuan, Ruohan Sun, Fei Wang, Yang Li, Hui Li, Fengjiao Yuan, Qing Fan, Zhenxiong Zhao

Journal: Mol Pharm

PubMed ID: 36315025

Doi: 10.1021/acs.molpharmaceut.2c00708

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A method for targeting a specified segment of DNA to a bacterial microorganelle

Authors: Jan Otoničar, Maja Hostnik, Maja Grundner, Rok Kostanjšek, Tajda Gredar, Maja Garvas, Zoran Arsov, Zdravko Podlesek, Cene Gostinčar, Jernej Jakše, Stephen J W Busby, Matej Butala

Journal: Nucleic Acids Res

PubMed ID: 36029110

Doi: 10.1093/nar/gkac714

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Cancer stem cell antigen nanodisc cocktail elicits anti-tumor immune responses in melanoma

Authors: Marisa E Aikins, You Qin, Hannah E Dobson, Alireza Hassani Najafabadi, Kexing Lyu, Yao Xu, Ying Xin, Anna Schwendeman, Max S Wicha, Alfred E Chang, Qiao Li, James J Moon

Journal: J Control Release

PubMed ID: 36206945

Doi: 10.1016/j.jconrel.2022.09.061

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Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library

Authors: Devan J Shell, Justin M Rectenwald, Peter H Buttery, Rebecca L Johnson, Caroline A Foley, Shiva K R Guduru, Mélanie Uguen, Juanita Sanchez Rubiano, Xindi Zhang, Fengling Li, Jacqueline L Norris-Drouin, Matthew Axtman, P Brian Hardy, Masoud Vedadi, Stephen V Frye, Lindsey I James, Kenneth H Pearce

Journal: SLAS Discov

PubMed ID: 36272689

Doi: 10.1016/j.slasd.2022.10.003

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Energy landscape reshaped by strain-specific mutations underlies epistasis in NS1 evolution of influenza A virus

Authors: Iktae Kim, Alyssa Dubrow, Bryan Zuniga, Baoyu Zhao, Noah Sherer, Abhishek Bastiray, Pingwei Li, Jae-Hyun Cho

Journal: Nat Commun

PubMed ID: 36182933

Doi: 10.1038/s41467-022-33554-9

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GITRL impairs the immunosuppressive function of MDSCs via PTEN-mediated signaling pathway in experimental Sjögren syndrome

Authors: Jie Tian, Beibei Zhang, Qingfang Yuan, Xueqing Sun, Na Peng, Bo Zhu, Chang Liu, Xiaoran Wang, Man Han, Meng Cao, Fan Xiao, Shengjun Wang, Ke Rui, Liwei Lu

Journal: Inflamm Res

PubMed ID: 36301339

Doi: 10.1007/s00011-022-01660-5

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An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation

Authors: Merve Avar, Daniel Heinzer, Alana M Thackray, Yingjun Liu, Marian Hruska-Plochan, Stefano Sellitto, Elke Schaper, Daniel P Pease, Jiang-An Yin, Asvin Kk Lakkaraju, Marc Emmenegger, Marco Losa, Andra Chincisan, Simone Hornemann, Magdalini Polymenidou, Raymond Bujdoso, Adriano Aguzzi

Journal: EMBO J

PubMed ID: 36254605

Doi: 10.15252/embj.2022112338

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Priming conditions shape breadth of neutralizing antibody responses to sarbecoviruses

Authors: Janice Zhirong Jia, Chee Wah Tan, Samuel M S Cheng, Haogao Gu, Aileen Ying Yan Yeoh, Chris Ka Pun Mok, Yanqun Wang, Jincun Zhao, Nancy H L Leung, Benjamin J Cowling, Leo L M Poon, David S C Hui, Linfa Wang, Malik Peiris, Sophie A Valkenburg

Journal: Nat Commun

PubMed ID: 36271047

Doi: 10.1038/s41467-022-34038-6

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Inhibition of Glypican-3 Cleavage Results in Reduced Cell Proliferation in a Liver Cancer Cell Line

Authors: Emily J Schepers, Charissa Lake, Kathryn Glaser, Alexander J Bondoc

Journal: J Surg Res

PubMed ID: 36272230

Doi: 10.1016/j.jss.2022.09.011

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Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

Authors: Tilman L B Hölting, Florencia Cidre-Aranaz, Dana Matzek, Bastian Popper, Severin J Jacobi, Cornelius M Funk, Florian H Geyer, Jing Li, Ignazio Piseddu, Bruno L Cadilha, Stephan Ledderose, Jennifer Zwilling, Shunya Ohmura, David Anz, Annette Künkele, Frederick Klauschen, Thomas G P Grünewald, Maximilian M L Knott

Journal: Mol Cancer

PubMed ID: 36229873

Doi: 10.1186/s12943-022-01641-6

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An inducible gene from glycoside hydrolase one family of decreases larval survival when feeding on host plant

Authors: Wei Chen, Yuhong Dong, Ling Zheng, Yingfang Lai, Feifei Li, Li Zhou, Beibei Wang, Minsheng You, Weiyi He

Journal: Front Physiol

PubMed ID: 36338470

Doi: 10.3389/fphys.2022.1013092

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Combating the SARS-CoV-2 Omicron (BA1) and BA2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies

Authors: Yingdan Wang, Xiang Zhang, Yunping Ma, Yanqun Wang, Wuqiang Zhan, Qinwen Zheng, Meng Zhang, Ping Ji, Mei Liu, Qianying Liu, Tingting Sun, Tongyu Zhu, Yumei Wen, Lei Sun, Jincun Zhao, Fan Wu, Zhenguo Chen, Jinghe Huang

Journal: Cell Discov

PubMed ID: 36207299

Doi: 10.1038/s41421-022-00463-6

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Active Pharmaceutical Ingredient Uptake by Zebrafish (Danio rerio) Oct2 (slc22a2) Transporter Expressed in Xenopus laevis Oocytes

Authors: Elisabeth D Chang, Stewart F Owen, Christer Hogstrand, Nic R Bury

Journal: Environ Toxicol Chem

PubMed ID: 36102855

Doi: 10.1002/etc.5480

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Protein kinase C beta relieves autism-like behavior in EN2 knockout mice via upregulation of the FTO/PGC-1α/UCP1 axis

Authors: Xingyu Song, Qibo Hu, Xiaoheng Xu, Wei Pan

Journal: J Biochem Mol Toxicol

PubMed ID: 36239013

Doi: 10.1002/jbt.23236

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Macromolecular crowding amplifies allosteric regulation of T-Cell Protein Tyrosine Phosphatase

Authors: May Thwe Tun, Shen Yang, Fabio Luis Forti, Eugenio Santelli, Nunzio Bottini

Journal: J Biol Chem

PubMed ID: 36328244

Doi: 10.1016/j.jbc.2022.102655

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A broadly protective vaccine against cutaneous human papillomaviruses

Authors: Filipe Colaco Mariz, Kathrin Balz, Manuela Dittrich, Yueru Zhang, Fan Yang, Xueer Zhao, Angelo Bolchi, Simone Ottonello, Martin Müller

Journal: npj Vaccines

PubMed ID: 36216845

Doi: 10.1038/s41541-022-00539-0

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Comparison of the kinetics and magnitude of antibody responses to different SARS-CoV-2 proteins in Sinopharm/BBIBP-CorV vaccinees following the BNT162b2 booster or natural infection

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Shashika Dayarathna, Thashmi Nimasha, Thushali Ranasinghe, Jeewantha Jayamali, Achala Kamaladasa, Maneshka Karunanada, Lahiru Perera, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: PLoS ONE

PubMed ID: 36227884

Doi: 10.1371/journal.pone.0274845

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Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination

Authors: Jia Xin Chua, Lindy Gillian Durrant, Yin Ling Chok, Oi Ming Lai

Journal: iScience

PubMed ID: 36277260

Doi: 10.1016/j.isci.2022.105379

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Identifying a novel role for the master regulator Tal1 in the Endothelial to Hematopoietic Transition

Authors: Yasmin Natalia Serina Secanechia, Isabelle Bergiers, Matt Rogon, Christian Arnold, Nicolas Descostes, Stephanie Le, Natalia López-Anguita, Kerstin Ganter, Chrysi Kapsali, Lea Bouilleau, Aaron Gut, Auguste Uzuotaite, Ayshan Aliyeva, Judith B Zaugg, Christophe Lancrin

Journal: Sci Rep

PubMed ID: 36217016

Doi: 10.1038/s41598-022-20906-0

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Long Noncoding RNA LINC00909 Induces Epithelial-Mesenchymal Transition and Contributes to Osteosarcoma Tumorigenesis and Metastasis

Authors: Wanshun Liu, Qi Zhang, Kai Shen, Keran Li, Jie Chang, He Li, Ao Duan, Sheng Zhang, Yumin Huang

Journal: J Oncol

PubMed ID: 36262353

Doi: 10.1155/2022/8660965

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Insertion of circularly permuted cyan fluorescent protein into the ligand-binding domain of inositol 1,4,5-trisphosphate receptor for enhanced FRET upon binding of fluorescent ligand

Authors: Azmeree Jahan, Mst Tahmina Akter, Kiwamu Takemoto, Tai Oura, Akiko Shitara, Shingo Semba, Akihiro Nezu, Satoshi Suto, Takeharu Nagai, Akihiko Tanimura

Journal: Cell Calcium

PubMed ID: 36335765

Doi: 10.1016/j.ceca.2022.102668

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CRISPR/Cas Precisely Regulated DNA-Templated Silver Nanocluster Fluorescence Sensor for Meat Adulteration Detection

Authors: Jiahui Chen, Jianghua Liu, Di Wu, Ruiyuan Pan, Jian Chen, Yongning Wu, Mingquan Huang, Guoliang Li

Journal: J Agric Food Chem

PubMed ID: 36288511

Doi: 10.1021/acs.jafc.2c04500

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Autophagy Regulates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells Induced by Orthodontic Tension

Authors: Junyi Zheng, Bowen Xu, Kai Yang

Journal: Stem Cells Int

PubMed ID: 36248255

Doi: 10.1155/2022/2983862

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Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H αβ tetramer

Authors: Abhinandan V Murthy, Ramita Sulu, Andrey Lebedev, Antti M Salo, Kati Korhonen, Rajaram Venkatesan, Hongmin Tu, Ulrich Bergmann, Janne Jänis, Mikko Laitaoja, Lloyd W Ruddock, Johanna Myllyharju, M Kristian Koski, Rik K Wierenga

Journal: J Biol Chem

PubMed ID: 36265586

Doi: 10.1016/j.jbc.2022.102614

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Amphiphile-CpG vaccination induces potent lymph node activation and COVID-19 immunity in mice and non-human primates

Authors: Lochana M Seenappa, Aniela Jakubowski, Martin P Steinbuck, Erica Palmer, Christopher M Haqq, Crystal Carter, Jane Fontenot, Francois Villinger, Lisa K McNeil, Peter C DeMuth

Journal: npj Vaccines

PubMed ID: 36307453

Doi: 10.1038/s41541-022-00560-3

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Genome-Wide Identification and Functional Analysis of the Gene Family Responding to Multiple Stressors in

Authors: Mei Zhang, Zhengfeng Wang, Shuguang Jian

Journal: Genes (Basel)

PubMed ID: 36360226

Doi: 10.3390/genes13111988

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The synergism of lytic polysaccharide monooxygenases with lichenase and their co-immobilization on silica nanospheres for green conversion of lichen biomass

Authors: Lixi Cai, Ying Zheng, Yunmeng Chu, Yuanqing Lin, Lixing Liu, Guangya Zhang

Journal: Front Nutr

PubMed ID: 36337671

Doi: 10.3389/fnut.2022.970540

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Safety, efficacy, and DIVA feasibility on a novel live attenuated classical swine fever marker vaccine candidate

Authors: Chao Tong, Huanhuan Liu, Jiaying Wang, Yanyong Sun, Ning Chen

Journal: Vaccine

PubMed ID: 36328881

Doi: 10.1016/j.vaccine.2022.10.035

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Accelerated DNA vaccine regimen provides protection against Crimean-Congo hemorrhagic fever virus challenge in a macaque model

Authors: David W Hawman, Kimberly Meade-White, Shanna Leventhal, Sofia Appelberg, Gustaf Ahlén, Negin Nikouyan, Chad Clancy, Brian Smith, Patrick Hanley, Jamie Lovaglio, Ali Mirazimi, Matti Sällberg, Heinz Feldmann

Journal: Mol Ther

PubMed ID: 36184852

Doi: 10.1016/j.ymthe.2022.09.016

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HCV Infection Increases the Expression of ACE2 Receptor, Leading to Enhanced Entry of Both HCV and SARS-CoV-2 into Hepatocytes and a Coinfection State

Authors: Tom Domovitz, Samer Ayoub, Michal Werbner, Joel Alter, Lee Izhaki Tavor, Yfat Yahalom-Ronen, Evgeny Tikhonov, Tomer Meirson, Yaakov Maman, Nir Paran, Tomer Israely, Moshe Dessau, Meital Gal-Tanamy

Journal: Microbiol Spectr

PubMed ID: 36314945

Doi: 10.1128/spectrum.01150-22

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Construction of a bioluminescence-based assay for bitter taste receptors (TAS2Rs)

Authors: Shi Min Tan, Wei-Guang Seetoh

Journal: Sci Rep

PubMed ID: 36271274

Doi: 10.1038/s41598-022-21678-3

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Recent reconfiguration of an ancient developmental gene regulatory network in Heliocidaris sea urchins

Authors: Phillip L Davidson, Haobing Guo, Jane S Swart, Abdull J Massri, Allison Edgar, Lingyu Wang, Alejandro Berrio, Hannah R Devens, Demian Koop, Paula Cisternas, He Zhang, Yaolei Zhang, Maria Byrne, Guangyi Fan, Gregory A Wray

Journal: Nat Ecol Evol

PubMed ID: 36266460

Doi: 10.1038/s41559-022-01906-9

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Structural basis of TRPV3 inhibition by an antagonist

Authors: Junping Fan, Linghan Hu, Zongwei Yue, Daohong Liao, Fusheng Guo, Han Ke, Daohua Jiang, Yong Yang, Xiaoguang Lei

Journal: Nat Chem Biol

PubMed ID: 36302896

Doi: 10.1038/s41589-022-01166-5

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Deciphering the Alphabet of Disorder-Glu and Asp Act Differently on Local but Not Global Properties

Authors: Mette Ahrensback Roesgaard, Jeppe E Lundsgaard, Estella A Newcombe, Nina L Jacobsen, Francesco Pesce, Emil E Tranchant, Søren Lindemose, Andreas Prestel, Rasmus Hartmann-Petersen, Kresten Lindorff-Larsen, Birthe B Kragelund

Journal: Biomolecules

PubMed ID: 36291634

Doi: 10.3390/biom12101426

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Characteristics of a new carotenoid cleavage dioxygenase NtCCD10 derived from Nicotiana tabacum

Authors: Fan Li, Xiaowei Gong, Yupeng Liang, Lijuan Peng, Xiulin Han, Mengliang Wen

Journal: Planta

PubMed ID: 36251100

Doi: 10.1007/s00425-022-04013-y

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Outliers Matter-Correlation between S1 IgG SARS-CoV-2 Antibodies and Neutralizing SARS-CoV-2 Antibodies

Authors: Berthold Hocher, Anne Schönbrunn, Xin Chen, Bernhard K Krämer, Volker von Baehr

Journal: Microorganisms

PubMed ID: 36296343

Doi: 10.3390/microorganisms10102067

Neutralizing Antibody Responses Among Residents and Staff of Long-Term Care Facilities in the State of New Jersey During the First Wave of the COVID-19 Pandemic

Authors: Stephen M Friedman, Jieliang Li, Pauline Thomas, Manisha Gurumurthy, Richard Siderits, Anna Nepomich, Edward Lifshitz

Journal: J Community Health

PubMed ID: 36197535

Doi: 10.1007/s10900-022-01142-z

Resistance of SARS-CoV-2 Omicron variant to convalescent and CoronaVac vaccine plasma

Authors: Yingdan Wang, Yunping Ma, Yan Xu, Jiangyan Liu, Xiang Li, Yuyuan Chen, Yan Chen, Jun Xie, Lianbo Xiao, Zheng Xiang, Fan Wu, Jinghe Huang

Journal: Emerg Microbes Infect

PubMed ID: 35001836

Doi: 10.1080/22221751.2022.2027219

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Bridging the gap between maleate hydratase, citraconase and isopropylmalate isomerase: Insights into the single broad-specific enzyme

Authors: Akila Thirumalai, Padmapriya Ganapathy Raman, Tamilselvan Jayavelu, Ramalingam Subramanian

Journal: Enzyme Microb Technol

PubMed ID: 36272242

Doi: 10.1016/j.enzmictec.2022.110140

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Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion

Authors: Palak N Patel, Thayne H Dickey, Christine S Hopp, Ababacar Diouf, Wai Kwan Tang, Carole A Long, Kazutoyo Miura, Peter D Crompton, Niraj H Tolia

Journal: Nat Commun

PubMed ID: 36202833

Doi: 10.1038/s41467-022-33336-3

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Development of Enzymatic Depletion Methods for Preparation of Small Extracellular Vesicles with Long Blood-Circulation Half-Life

Authors: Yuki Kobayashi, Shimpei Kitamura, Yuki Takahashi, Yoshinobu Takakura

Journal: Pharm Res

PubMed ID: 36195822

Doi: 10.1007/s11095-022-03405-9

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Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques

Authors: Pingchao Li, Qian Wang, Yizi He, Chenchen Yang, Zhengyuan Zhang, Zijian Liu, Bo Liu, Li Yin, Yilan Cui, Peiyu Hu, Yichu Liu, Pingqian Zheng, Wei Wang, Linbing Qu, Caijun Sun, Suhua Guan, Liqiang Feng, Ling Chen

Journal: Emerg Microbes Infect

PubMed ID: 36239345

Doi: 10.1080/22221751.2022.2136538

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Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP

Authors: Maria A Schumacher, Mirka E Wörmann, Max Henderson, Raul Salinas, Andreas Latoscha, Mahmoud M Al-Bassam, Kumar Siddharth Singh, Elaine Barclay, Katrin Gunka, Natalia Tschowri

Journal: Nat Commun

PubMed ID: 36192422

Doi: 10.1038/s41467-022-33537-w

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Targeting SARS-CoV-2 infection through CAR-T-like bispecific T cell engagers incorporating ACE2

Authors: Mikail Dogan, Lina Kozhaya, Lindsey Placek, Fatih Karabacak, Mesut Yigit, Derya Unutmaz

Journal: Clin Transl Immunology

PubMed ID: 36285327

Doi: 10.1002/cti2.1421

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A non-canonical RNA-binding domain of the Fragile X protein, FMRP, elicits translational repression independent of mRNA G-quadruplexes

Authors: MaKenzie R Scarpitti, Julia E Warrick, Evelyn L Yoder, Michael G Kearse

Journal: J Biol Chem

PubMed ID: 36328245

Doi: 10.1016/j.jbc.2022.102660

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miR-275/305 cluster is essential for maintaining energy metabolic homeostasis by the insulin signaling pathway in Bactrocera dorsalis

Authors: Junfei Xie, Hao Chen, Wenping Zheng, Zhaohui Cai, Xiaoxue Li, Hongyu Zhang

Journal: PLOS Genetics

Doi: 10.1371/journal.pgen.1010418

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Mannose and Hyaluronic Acid Dual-Modified Iron Oxide Enhances Neoantigen-Based Peptide Vaccine Therapy by Polarizing Tumor-Associated Macrophages

Authors: Ying Nie , Lu Shi , Yanan Zhang , Yunfei Guo , Hongchen Gu

Journal: Cancers

PubMed ID: 36291890

Doi: /10.3390/cancers14205107

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Author Correction: Omicron BA4/BA5 escape neutralizing immunity elicited by BA1 infection

Authors: Khadija Khan, Farina Karim, Yashica Ganga, Mallory Bernstein, Zesuliwe Jule, Kajal Reedoy, Sandile Cele, Gila Lustig, Daniel Amoako, Nicole Wolter, Natasha Samsunder, Aida Sivro, James Emmanuel San, Jennifer Giandhari, Houriiyah Tegally, Sureshnee Pillay, Yeshnee Naidoo, Matilda Mazibuko, Yoliswa Miya, Nokuthula Ngcobo, Nithendra Manickchund, Nombulelo Magula, Quarraisha Abdool Karim, Anne von Gottberg, Salim S Abdool Karim, Willem Hanekom, Bernadett I Gosnell, Richard J Lessells, Tulio de Oliveira, Mahomed-Yunus S Moosa, Alex Sigal

Journal: Nat Commun

PubMed ID: 36229444

Doi: 10.1038/s41467-022-33371-0

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MnO Nanozyme-Mediated CRISPR-Cas12a System for the Detection of SARS-CoV-2

Authors: Lina Wu, Xinjie Wang, Xiangchuan Wu, Shiqi Xu, Ming Liu, Xizhong Cao, Taishan Tang, Xingxu Huang, He Huang

Journal: ACS Appl Mater Interfaces

PubMed ID: 36301087

Doi: 10.1021/acsami.2c14497

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