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Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology

Authors: Giavanna Paterno, Brach M Bell, Kimberly-Marie M Gorion, Stefan Prokop, Benoit I Giasson

Journal: Acta Neuropathol Commun

PubMed ID: 35765058

Doi: 10.1186/s40478-022-01394-9

Products & Services: Mammalian Expression

A Novel Synthetic Antibody Library with Complementarity-Determining Region Diversities Designed for an Improved Amplification Profile

Authors: Xuelian Bai, Moonseon Jang, Nam Ju Lee, Thi Thu Ha Nguyen, Mooyoung Jung, Jeong Yeon Hwang, Hyunbo Shim

Journal: Int J Mol Sci

PubMed ID: 35682935

Doi: 10.3390/ijms23116255

Products & Services: Codon Optimization

Isogenic GAA-KO Murine Muscle Cell Lines Mimicking Severe Pompe Mutations as Preclinical Models for the Screening of Potential Gene Therapy Strategies

Authors: Araceli Aguilar-González, Juan Elías González-Correa, Eliana Barriocanal-Casado, Iris Ramos-Hernández, Miguel A Lerma-Juárez, Sara Greco, Juan José Rodríguez-Sevilla, Francisco Javier Molina-Estévez, Valle Montalvo-Romeral, Giuseppe Ronzitti, Rosario María Sánchez-Martín, Francisco Martín, Pilar Muñoz

Journal: Int J Mol Sci

PubMed ID: 35682977

Doi: 10.3390/ijms23116298

Products & Services: Plasmid DNA Preparation

Characterization of novel antimicrobial peptides designed on the basis of amino acid sequence of peptides from egg white hydrolysate

Authors: Cunkuan Shen, Yunzhi Lin, Tahir Noor Mohammadi, Yoshimitsu Masuda, Ken-Ichi Honjoh, Takahisa Miyamoto

Journal: Int J Food Microbiol

PubMed ID: 35752018

Doi: 10.1016/j.ijfoodmicro.2022.109802

Products & Services: Peptide Synthesis

Novel switchable ECF sigma factor transcription system for improving thaxtomin A production in

Authors: Xuejin Zhao, Weijia Wei, Yeqing Zong, Chaoxian Bai, Xian Guo, Hua Zhu, Chunbo Lou

Journal: Synth Syst Biotechnol

PubMed ID: 35756964

Doi: 10.1016/j.synbio.2022.05.010

Products & Services: Gene Synthesis

Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans

Authors: Xin-Zi Emily Tang, Shu Xuan Tan, Shawn Hoon, Gene W Yeo

Journal: Nat Med

PubMed ID: 35668177

Doi: 10.1038/s41591-022-01848-6

Products & Services: Recombinant Antibody Expression

Identification of Antigenic Properties of Acinetobacter baumannii Proteins as Novel Putative Vaccine Candidates Using Reverse Vaccinology Approach

Authors: Tohid Piri-Gharaghie, Abbas Doosti, Seyed Abbas Mirzaei

Journal: Appl Biochem Biotechnol

PubMed ID: 35670904

Doi: 10.1007/s12010-022-03995-5

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COVID-19 redux: clinical, virologic, and immunologic evaluation of clinical rebound after nirmatrelvir/ritonavir

Authors: Brian P Epling, Joseph M Rocco, Kristin L Boswell, Elizabeth Laidlaw, Frances Galindo, Anela Kellogg, Sanchita Das, Allison Roder, Elodie Ghedin, Allie Kreitman, Robin L Dewar, Sophie E M Kelly, Heather Kalish, Tauseef Rehman, Jeroen Highbarger, Adam Rupert, Gregory Kocher, Michael R Holbrook, Andrea Lisco, Maura Manion, Richard A Koup, Irini Sereti

Journal: medrxiv

PubMed ID: 35734093

Doi: 10.1101/2022.06.16.22276392

Divergent cis-regulatory evolution underlies the convergent loss of sodium channel expression in electric fish

Authors: Sarah LaPotin, Mary E Swartz, David M Luecke, Savvas J Constantinou, Jason R Gallant, Johann K Eberhart, Harold H Zakon

Journal: Sci Adv

PubMed ID: 35648851

Doi: 10.1126/sciadv.abm2970

Products & Services: Mutagenesis Services

Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling

Authors: Airah Javorsky, Patrick O Humbert, Marc Kvansakul

Journal: Biochem J

PubMed ID: 35670457

Doi: 10.1042/BCJ20220037

Products & Services: Proteins, Expression, Isolation and Analysis

Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR)

Authors: Johannes C van der Mijn, Qiuying Chen, Kristian B Laursen, Francesca Khani, Xiaofei Wang, Princesca Dorsaint, Andrea Sboner, Steven S Gross, David M Nanus, Lorraine J Gudas

Journal: Mol Carcinog

PubMed ID: 35726553

Doi: 10.1002/mc.23437

Products & Services: Proteins, Expression, Isolation and Analysis

Apo-Form Selective Inhibition of IDO for Tumor Immunotherapy

Authors: Wen Liu, Yi Zou, Kaiming Li, Haiqing Zhong, Longbo Yu, Shushan Ge, Yisheng Lai, Xianchi Dong, Qiang Xu, Wenjie Guo

Journal: J Immunol

PubMed ID: 35725271

Doi: 10.4049/jimmunol.2100938

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Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infection

Authors: Amy R Rappaport, Sue-Jean Hong, Ciaran D Scallan, Leonid Gitlin, Arvin Akoopie, Gregory R Boucher, Milana Egorova, J Aaron Espinosa, Mario Fidanza, Melissa A Kachura, Annie Shen, Gloria Sivko, Anne Van Abbema, Robert L Veres, Karin Jooss

Journal: Nat Commun

PubMed ID: 35672369

Doi: 10.1038/s41467-022-31005-z

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Linear DNA amplicons as a novel cancer vaccine strategy

Authors: Antonella Conforti, Erika Salvatori, Lucia Lione, Mirco Compagnone, Eleonora Pinto, Clay Shorrock, James A Hayward, Yuhua Sun, Ben Minghwa Liang, Fabio Palombo, Brian Viscount, Luigi Aurisicchio

Journal: J Exp Clin Cancer Res

PubMed ID: 35668533

Doi: 10.1186/s13046-022-02402-5

Products & Services: DNA Sequencing

Shelterin Components Modulate Nucleic Acids Condensation and Phase Separation in the Context of Telomeric DNA

Authors: Andrea Soranno, J Jeremías Incicco, Paolo De Bona, Eric J Tomko, Eric A Galburt, Alex S Holehouse, Roberto Galletto

Journal: J Mol Biol

PubMed ID: 35724929

Doi: 10.1016/j.jmb.2022.167685

Products & Services: PCR and Cloning

A prion-like domain of TFEB mediates the co-aggregation of TFEB and mHTT

Authors: Junsheng Yang, Huilin Xu, Chaoyue Zhang, Xiaotong Yang, Weijie Cai, Xiaoli Chen

Journal: Autophagy

PubMed ID: 35635192

Doi: 10.1080/15548627.2022.2083857

Products & Services: Proteins, Expression, Isolation and Analysis

Asexual Blood-Stage Malaria Vaccine Candidate PfRipr5: Enhanced Production in Insect Cells

Authors: Ricardo Correia, Bárbara Fernandes, Rute Castro, Hikaru Nagaoka, Eizo Takashima, Takafumi Tsuboi, Akihisa Fukushima, Nicola K Viebig, Hilde Depraetere, Paula M Alves, António Roldão

Journal: Front Bioeng Biotechnol

PubMed ID: 35845392

Doi: 10.3389/fbioe.2022.908509

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A cytosolic pentatricopeptide repeat protein is essential for tapetal plastid development by regulating OsGLK1 transcript levels in rice

Authors: Shaoyan Zheng , Jingfang Dong , Jingqin Lu , Jing Li , Dagang Jiang , Haopeng Yu , Simiao Ye , Wenli Bu , Zhenlan Liu , Hai Zhou , Yiliang Ding , Chuxiong Zhuang

Journal: New Phytol .

PubMed ID: 35306663

Doi: 10.1111/nph.18105

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The Texture Change of Chinese Traditional Pig Trotter with Soy Sauce during Stewing Processing: Based on a Thermal Degradation Model of Collagen Fibers

Authors: Yuhai Lin, Ying Wang, Guofeng Jin, Junjie Duan, Yuemei Zhang, Jinxuan Cao

Journal: Foods

PubMed ID: 35741970

Doi: 10.3390/foods11121772

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PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal mast cells

Authors: Fan Ye, Yucui Jiang, Yingxin Zong, Jian Zhang, Chan Zhu, Yan Yang, Zongxiang Tang

Journal: Immunol Lett

PubMed ID: 35714789

Doi: 10.1016/j.imlet.2022.06.006

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Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain

Authors: Airah Javorsky, Patrick O Humbert , Marc Kvansakul

Journal: Commun Biol

PubMed ID: 34117354

Doi: 10.1038/s42003-021-02250-7

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LcCCL28-25, Derived from Piscine Chemokine, Exhibits Antimicrobial Activity against Gram-Negative and Gram-Positive Bacteria In Vitro and In Vivo

Authors: Juanjuan Su , Haimeng Li , Jingyang Hu , Danni Wang , Fengchao Zhang , Zheng Fu , Feng Han

Journal: Microbiol Spectr

PubMed ID: 35616397

Doi: 10.1128/spectrum.02515-21

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Umami polypeptide detection system targeting the human T1R1 receptor and its taste-presenting mechanism

Authors: Chuanxi Zhang , Yulu Miao , Yinghui Feng , Jiawei Wang , Zhuoli Tian , Juan Dong , Bei Gao , Lujia Zhang

Journal: Biomaterials

PubMed ID: 35792387

Doi: doi.org/10.1016/j.biomaterials.2022.121660

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Staphylococcal saoABC operon codes for a DNA-binding protein SaoC implicated in the response to nutrient deficit

Authors: Michal Bukowski , Maja Kosecka-Strojek , Anna Madry , Rafal Zagorski-Przybylo , Tomasz Zadlo , Katarzyna Gawron , Benedykt Wladyka

Journal: Int J Mol Sci

PubMed ID: 35742885

Doi: 10.3390/ijms23126443

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3D structure and in situ arrangements of CatSper channel in the sperm flagellum

Authors: Yanhe Zhao , Huafeng Wang , Caroline Wiesehoefer , Naman B Shah , Evan Reetz , Jae Yeon Hwang , Xiaofang Huang , Tse-En Wang , Polina V Lishko , Karen M Davies , Gunther Wennemuth , Daniela Nicastro , Jean-Ju Chung

Journal: Nat Commun

PubMed ID: 35715406

Doi: 10.1038/s41467-022-31050-8

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A Five Year Randomized Controlled Trial to Assess the Efficacy and Antibody Responses to a Commercial and Autogenous Vaccine for the Prevention of Infectious Bovine Keratoconjunctivitis

Authors: Matthew M Hille, Matthew L Spangler, Michael L Clawson, Kelly D Heath, Hiep L X Vu, Rachel E S Rogers, John Dustin Loy

Journal: Vaccines (Basel)

PubMed ID: 35746524

Doi: 10.3390/vaccines10060916

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A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis

Authors: Monir Ejemel, Todd G Smith, Lauren Greenberg, William C Carson, David Lowe, Yong Yang, Felix R Jackson, Clint N Morgan, Brock E Martin, Chantal Kling, Christina L Hutson, Nadia Gallardo-Romero, James A Ellison, Susan Moore, Adam Buzby, John Sullivan-Bolyai, Mark Klempner, Yang Wang

Journal: Sci Rep

PubMed ID: 35672343

Doi: 10.1038/s41598-022-13527-0

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Recombinant chimpanzee adenovirus vector vaccine expressing the spike protein provides effective and lasting protection against SARS-CoV-2 infection in mice

Authors: Mingqing Lu, Kunpeng Liu, Yun Peng, Zhe Ding, Yingwen Li, Alexander Tendu, Xue Hu, Ge Gao, Weiwei Guo, Hang Liu, Juhong Rao, Jiaxuan Zhao, Miaoyu Chen, Zhiming Yuan, Gary Wong, Chao Shan, Yanfeng Yao, Jiaming Lan

Journal: Virol Sin

PubMed ID: 35659605

Doi: 10.1016/j.virs.2022.05.006

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The Role of Dihydroresveratrol in Enhancing the Synergistic Effect of Li01 and Resveratrol in Ameliorating Colitis in Mice

Authors: Yiqiu Fei, Shuobo Zhang, Shengyi Han, Bo Qiu, Yanmeng Lu, Weixing Huang, Fang Li, Deying Chen, Björn Berglund, Hang Xiao, Lanjuan Li, Mingfei Yao

Journal: Research (Wash D C)

PubMed ID: 35935130

Doi: 10.34133/2022/9863845

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Excessive Immune Activation and the Correlation with Decreased Expression of PD-1 at the Maternal-Fetal Interface in Preeclampsia

Authors: Shan Wang, Yining Liu, Yue Liang, Lina Sun, Xiaoxiao Du, Yueyang Shi, Jinlai Meng

Journal: Reprod Sci

PubMed ID: 35708884

Doi: 10.1007/s43032-022-01003-z

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Patulin Detoxification by Recombinant Manganese Peroxidase from Expressed by

Authors: Shuai Wang, Xiaolu Wang, Leena Penttinen, Huiying Luo, Yuhong Zhang, Bo Liu, Bin Yao, Nina Hakulinen, Wei Zhang, Xiaoyun Su

Journal: Toxins (Basel)

PubMed ID: 35878178

Doi: 10.3390/toxins14070440

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Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naïve CD8 T Cell Activation and Expansion by Promoting T Cell-APC Interactions

Authors: Monique M Waldman, Jeremy T Rahkola, Ashton L Sigler, Jeffrey W Chung, Benjamin A S Willett, Ross M Kedl, Rachel S Friedman, Jordan Jacobelli

Journal: Front Immunol

PubMed ID: 35757762

Doi: 10.3389/fimmu.2022.856977

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PD-L1 in gestational trophoblastic disease: an antibody evaluation

Authors: Yvonne M Hoeijmakers, Michiel Simons, Johan Bulten, Mark A J Gorris, Petronella B Ottevanger, I Jolanda M de Vries, Fred C G J Sweep

Journal: Acta Obstet Gynecol Scand

PubMed ID: 35689468

Doi: 10.1111/aogs.14404

Products & Services: Recombinant Proteins

The simultaneous perception of self- and non-self-danger signals potentiates plant innate immunity responses

Authors: Victoria Pastor, Raquel Cervero, Jordi Gamir

Journal: Planta

PubMed ID: 35697869

Doi: 10.1007/s00425-022-03918-y

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Genetic characterization of the cyclohexane carboxylate degradation pathway in the denitrifying bacterium Aromatoleum sp CIB

Authors: David Sanz, Eduardo Díaz

Journal: Environ Microbiol

PubMed ID: 35768954

Doi: 10.1111/1462-2920.16093

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A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis

Authors: Caroline De Souza Pereira, Helenita Costa Quadros, Samuel Yaw Aboagye, Diana Fontinha, Sarah D'Alessandro, Margaret Elizabeth Byrne, Mathieu Gendrot, Isabelle Fonta, Joel Mosnier, Diogo Rodrigo M Moreira, Nicoletta Basilico, David L Williams, Miguel Prudêncio, Bruno Pradines, Maribel Navarro

Journal: Pharmaceutics

PubMed ID: 35745823

Doi: 10.3390/pharmaceutics14061251

Products & Services: Mammalian Expression

Engineering a highly sensitive biosensor for abscisic acid in mammalian cells

Authors: Seo Woo Kim, Kübra Alci, Femke Van Gaever, Yasmine Driege, Keylla Bicalho, Geert Goeminne, Claude Libert, Alain Goossens, Rudi Beyaert, Jens Staal

Journal: FEBS Lett

PubMed ID: 35727199

Doi: 10.1002/1873-3468.14431

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Mapping the deformability of natural and designed cellulosomes in solution

Authors: Jonathan Dorival, Sarah Moraïs, Aurore Labourel, Bartosz Rozycki, Pierre-Andre Cazade, Jérôme Dabin, Eva Setter-Lamed, Itzhak Mizrahi, Damien Thompson, Aurélien Thureau, Edward A Bayer, Mirjam Czjzek

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 35725490

Doi: 10.1186/s13068-022-02165-3

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The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication

Authors: Lucca R Policastro, Isabela Dolci, Andre S Godoy, José V J Silva Júnior, Uriel E A Ruiz, Igor A Santos, Ana C G Jardim, Kirandeep Samby, Jeremy N Burrows, Timothy N C Wells, Laura H V G Gil, Glaucius Oliva, Rafaela S Fernandes

Journal: Viruses

PubMed ID: 35891332

Doi: 10.3390/v14071351

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Gas5 inhibition promotes the axon regeneration in the adult mammalian nervous system

Authors: Xiaoxiao Han, Jiacheng Xu, Zixin Chen, Ping Li, Lili Zhao, Jincheng Tao, Yu Shen, Shengze Zhu, Bin Yu, Jianwei Zhu, Qianqian Cao, Songlin Zhou

Journal: Exp Neurol

PubMed ID: 35779613

Doi: 10.1016/j.expneurol.2022.114157

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ISCA2 deficiency leads to heme synthesis defects and impaired erythroid differentiation in K562 cells by indirect ROS-mediated IRP1 activation

Authors: Jing Wang, Mengyao Jiang, Guanru Yue, Lifei Zhu, Xueqing Wang, Mengxiang Liang, Xiaolin Wu, Beibei Li, Yilin Pang, Guoqiang Tan, Jianghui Li

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 35714932

Doi: 10.1016/j.bbamcr.2022.119307

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Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4

Authors: Hugh C Welles, Hannah A D King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A Schramm, Nicole A Doria-Rose, Adrienne E Swanstrom, James A Hoxie, Celia LaBranche, David C Montefiori, Daniel C Douek, Peter D Kwong, John R Mascola, Mario Roederer, Rosemarie D Mason

Journal: PLoS Pathog

PubMed ID: 35709309

Doi: 10.1371/journal.ppat.1010574

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A DNA vaccine candidate delivered by an electroacupuncture machine provides protective immunity against SARS-CoV-2 infection

Authors: Tsai-Teng Tzeng, Kit Man Chai, Kuan-Yin Shen, Chia-Yi Yu, Shiu-Ju Yang, Wan-Chun Huang, Hung-Chun Liao, Fang-Feng Chiu, Horng-Yunn Dou, Ching-Len Liao, Hsin-Wei Chen, Shih-Jen Liu

Journal: npj Vaccines

PubMed ID: 35662254

Doi: 10.1038/s41541-022-00482-0

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Immunoinformatics Design and Assessment of a Multiepitope Antigen (OvMCBL02) for Onchocerciasis Diagnosis and Monitoring

Authors: Bernis Neneyoh Yengo, Cabirou Mounchili Shintouo, An Hotterbeekx, Ntang Emmaculate Yaah, Robert Adamu Shey, Jusal Quanico, Geert Baggerman, Lawrence Ayong, Luc Vanhamme, Rose Njemini, Jacob Souopgui, Robert Colebunders, Stephen Mbigha Ghogomu

Journal: Diagnostics (Basel)

PubMed ID: 35741250

Doi: 10.3390/diagnostics12061440

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Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium

Authors: Aujan Mehregan, Sergio Pérez-Conesa, Yuxuan Zhuang, Ahmad Elbahnsi, Diletta Pasini, Erik Lindahl, Rebecca J Howard, Chris Ulens, Lucie Delemotte

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 35724739

Doi: 10.1016/j.bbamem.2022.183994

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RG2-VLP: a Vaccine Designed to Broadly Protect against Anogenital and Skin Human Papillomaviruses Causing Human Cancer

Authors: Pola Olczak, Ken Matsui, Margaret Wong, Jade Alvarez, Paul Lambert, Neil D Christensen, Jiafen Hu, Bettina Huber, Reinhard Kirnbauer, Joshua W Wang, Richard B S Roden

Journal: J Virol

PubMed ID: 35703545

Doi: 10.1128/jvi.00566-22

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Snake Venom Hydrogels as a Rapid Hemostatic Agent for Uncontrolled Bleeding

Authors: Ramanathan Yegappan, Jan Lauko, Zhao Wang, Martin F Lavin, Amanda W Kijas, Alan E Rowan

Journal: Adv Healthc Mater

PubMed ID: 35652565

Doi: 10.1002/adhm.202200574

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Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms

Authors: Jia Li, Tingting Hong, Yue Wei, Lei Guo, Minjung Lee, Hui Yang, Caleb Class, Yaling Yang, Xiaoqiong Wang, Hua He, Stefan Siwko, M James You, Yubin Zhou, Guillermo Garcia-Manero, Yun Huang

Journal: Clin Epigenetics

PubMed ID: 35765052

Doi: 10.1186/s13148-022-01297-5

Products & Services: Proteins, Expression, Isolation and Analysis

Metabolic sensor O-GlcNAcylation regulates erythroid differentiation and globin production via BCL11A

Authors: Sudjit Luanpitpong, Xing Kang, Montira Janan, Kanjana Thumanu, Jingting Li, Pakpoom Kheolamai, Surapol Issaragrisil

Journal: Stem Cell Res Ther

PubMed ID: 35739577

Doi: 10.1186/s13287-022-02954-5

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The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression

Authors: Jianchao Zhang, Xiaokai Fan, Yunfan Zhou, Liang Chen, Hai Rao

Journal: J Exp Clin Cancer Res

PubMed ID: 35655230

Doi: 10.1186/s13046-022-02400-7

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Location of the cross-β structure in prion fibrils: A search by seeding and electron spin resonance spectroscopy

Authors: Brett K-Y Chu, Ruei-Fong Tsai, Chien-Lun Hung, Yun-Hsuan Kuo, Eric H-L Chen, Yun-Wei Chiang, Sunney I Chan, Rita P-Y Chen

Journal: Protein Sci

PubMed ID: 35634767

Doi: 10.1002/pro.4326

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Laodelphax striatellus saliva mucin enables the formation of stylet sheathes to facilitate its feeding and rice stripe virus transmission

Authors: Yan Huo, Jing Zhao, Xiangyi Meng, Jie Yang, Ziyu Zhang, Zhiwei Liu, Rongxiang Fang, Lili Zhang

Journal: Pest Manag Sci

PubMed ID: 35604851

Doi: 10.1002/ps.6990

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Unbalanced regulation of Sec22b and Ykt6 blocks autophagosome axonal retrograde flux in neuronal ischemia-reperfusion injury

Authors: Haiying Li, Xiang Li, Zhongmou Xu, Jinxin Lu, Chang Cao, Wanchun You, Zhengquan Yu, Haitao Shen, Gang Chen

Journal: J Neurosci

PubMed ID: 35654605

Doi: 10.1523/JNEUROSCI.2030-21.2022

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CircFAT1 regulates retinal pigment epithelial cell pyroptosis and autophagy via mediating m6A reader protein YTHDF2 expression in diabetic retinopathy

Authors: Chengchi Huang, Peng Qi, Hao Cui, Qun Lu, Xue Gao

Journal: Exp Eye Res

PubMed ID: 35714699

Doi: 10.1016/j.exer.2022.109152

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Therapeutic use of α2-antiplasmin as an antifibrinolytic and hemostatic agent in surgery and regenerative medicine

Authors: Jialu Liu, Ani Solanki, Michael J V White, Jeffrey A Hubbell, Priscilla S Briquez

Journal: NPJ Regen Med

PubMed ID: 35773290

Doi: 10.1038/s41536-022-00230-x

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RANBP2 and USP9x regulate nuclear import of adenovirus minor coat protein IIIa

Authors: Ashrafali M Ismail, Amrita Saha, Ji S Lee, David F Painter, Yinghua Chen, Gurdeep Singh, Gabriela N Condezo, James Chodosh, Carmen San Martín, Jaya Rajaiya

Journal: PLoS Pathog

PubMed ID: 35709296

Doi: 10.1371/journal.ppat.1010588

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Computational design and engineering of an strain producing the nonstandard amino acid -aminophenylalanine

Authors: Ali R Zomorrodi, Colin Hemez, Pol Arranz-Gibert, Terrence Wu, Farren J Isaacs, Daniel Segrè

Journal: iScience

PubMed ID: 35789833

Doi: 10.1016/j.isci.2022.104562

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Intranasal vaccination of hamsters with a Newcastle disease virus vector expressing the S1 subunit protects animals against SARS-CoV-2 disease

Authors: Manolo Fernández Díaz, Katherine Calderón, Aldo Rojas-Neyra, Vikram N Vakharia, Ricardo Choque-Guevara, Angela Montalvan-Avalos, Astrid Poma-Acevedo, Dora Rios-Matos, Andres Agurto-Arteaga, Maria de Grecia Cauti-Mendoza, Norma Perez-Martinez, Gisela Isasi-Rivas, Luis Tataje-Lavanda, Yacory Sernaque-Aguilar, Freddy Ygnacio, Manuel Criollo-Orozco, Edison Huaccachi-Gonzalez, Elmer Delgado-Ccancce, Doris Villanueva-Pérez, Ricardo Montesinos-Millán, Kristel Gutiérrez-Manchay, Katherinne Pauyac-Antezana, Ingrid Ramirez-Ortiz, Stefany Quiñones-Garcia, Yudith Cauna-Orocollo, Katherine Vallejos-Sánchez, Angela Rios-Angulo, Dennis Núñez-Fernández, Mario I Salguedo-Bohorquez, Julio Ticona, Manolo Fernández-Sánchez, Eliana Icochea, Luis A Guevara-Sarmiento, Mirko Zimic

Journal: Sci Rep

PubMed ID: 35725862

Doi: 10.1038/s41598-022-13560-z

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Targeted removal of mitochondrial DNA from mouse and human extrachromosomal circular DNA with CRISPR-Cas9

Authors: Weijia Feng, Gerard Arrey, Egija Zole, Wei Lv, Xue Liang, Peng Han, Marghoob Mohiyuddin, Henriette Pilegaard, Birgitte Regenberg

Journal: Comput Struct Biotechnol J

PubMed ID: 35782732

Doi: 10.1016/j.csbj.2022.06.028

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A group of CLE peptides regulates de novo shoot regeneration in Arabidopsis thaliana

Authors: Jingke Kang, Xuening Wang, Takashi Ishida, Etienne Grienenberger, Qian Zheng, Jing Wang, Yonghong Zhang, Wenqiang Chen, Mengmeng Chen, Xiu-Fen Song, Chengyun Wu, Zhubing Hu, Lingyu Jia, Chen Li, Chun-Ming Liu, Jennifer C Fletcher, Shinichiro Sawa, Guodong Wang

Journal: New Phytol

PubMed ID: 35642449

Doi: 10.1111/nph.18291

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TCFL5 deficiency impairs the pachytene to diplotene transition during spermatogenesis in the mouse

Authors: Javier Galán-Martínez, Inés Berenguer, Ma Del Carmen Maza, Konstantinos Stamatakis, Núria Gironès, Manuel Fresno

Journal: Sci Rep

PubMed ID: 35768632

Doi: 10.1038/s41598-022-15167-w

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ZIC5 promotes human hepatocellular carcinoma cell proliferation through upregulating COL1A1

Authors: Wenping Song, Weijiang Yu, Ding Li, Cheng Cheng, Xuan Wu, Jinhua Chen, Wenzhou Zhang

Journal: J Gastrointest Oncol

PubMed ID: 35837163

Doi: 10.21037/jgo-22-335

Products & Services: Proteins, Expression, Isolation and Analysis

Mapping immunogenic epitopes of an adhesin-like protein from Methanobrevibacter ruminantium M1 and comparison of empirical data with in silico prediction methods

Authors: Sofia Khanum, Vincenzo Carbone, Sandeep K Gupta, Juliana Yeung, Dairu Shu, Tania Wilson, Natalie A Parlane, Eric Altermann, Silvia M Estein, Peter H Janssen, D Neil Wedlock, Axel Heiser

Journal: Sci Rep

PubMed ID: 35729277

Doi: 10.1038/s41598-022-14545-8

Products & Services: Proteins, Expression, Isolation and Analysis

CRISPR-mediated protein-tagging signal amplification systems for efficient transcriptional activation and repression in Saccharomyces cerevisiae

Authors: Haotian Zhai, Li Cui, Zhen Xiong, Qingsheng Qi, Jin Hou

Journal: Nucleic Acids Res

PubMed ID: 35641106

Doi: 10.1093/nar/gkac463

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Serological screening in wild ruminants in Germany, 2021/2022: No evidence of SARS-CoV-2, bluetongue virus or pestivirus spread but high seroprevalences against Schmallenberg virus

Authors: Kerstin Wernike, Luisa Fischer, Mark Holsteg, Andrea Aebischer, Anja Petrov, Katharina Marquart, Ulrich Schotte, Jacob Schön, Donata Hoffmann, Silke Hechinger, Antonie Neubauer-Juric, Julia Blicke, Thomas C Mettenleiter, Martin Beer

Journal: Transbound Emerg Dis

PubMed ID: 35585653

Doi: 10.1111/tbed.14600

Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum

Authors: Júlio Souza Dos-Santos, Luan Firmino-Cruz, Alessandra Marcia da Fonseca-Martins, Diogo Oliveira-Maciel, Gustavo Guadagnini Perez, Victor A Roncaglia-Pereira, Carlos H Dumard, Francisca H Guedes-da-Silva, Ana C Vicente Santos, Monique Dos Santos Leandro, Jesuino Rafael Machado Ferreira, Kamila Guimarães-Pinto, Luciana Conde, Danielle A S Rodrigues, Marcus Vinicius de Mattos Silva, Renata G F Alvim, Tulio M Lima, Federico F Marsili, Daniel P B Abreu, Orlando C Ferreira, Ronaldo da Silva Mohana Borges, Amilcar Tanuri, Thiago Moreno L Souza, Bartira Rossi-Bergmann, André M Vale, Jerson Lima Silva, Andréa Cheble de Oliveira, Alessandra D'Almeida Filardy, Andre M O Gomes, Herbert Leonel de Matos Guedes

Journal: Front Immunol

PubMed ID: 35844561

Doi: 10.3389/fimmu.2022.884760

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COVID-19 infection after two doses of SARS-CoV-2 mRNA vaccine in multiple sclerosis, AQP4-antibody NMOSD and MOGAD

Authors: Tianrong Yeo, Amy May Lin Quek, Kok Pin Yong, Janis Siew Noi Tye, Pavanni Ratnagopal, Derek Tuck Loong Soon, Kevin Tan

Journal: Mult Scler Relat Disord

PubMed ID: 35803084

Doi: 10.1016/j.msard.2022.104003

Megaviruses contain various genes encoding for eukaryotic vesicle trafficking factors

Authors: Dany Khalifeh, Emilie Neveu, Dirk Fasshauer

Journal: Traffic

PubMed ID: 35701729

Doi: 10.1111/tra.12860

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Plasminogen and plasmin can bind to human T cells and generate truncated CCL21 that increases dendritic cell chemotactic responses

Authors: Evert J Loef, Hilary M Sheppard, Nigel P Birch, P Rod Dunbar

Journal: J Biol Chem

PubMed ID: 35690148

Doi: 10.1016/j.jbc.2022.102112

Products & Services: Proteins, Expression, Isolation and Analysis

Irisin protects against sepsis-associated encephalopathy by suppressing ferroptosis via activation of the Nrf2/GPX4 signal axis

Authors: Jin Wang, Qian Zhu, Yun Wang, Jun Peng, Liang Shao, Xinyi Li

Journal: Free Radic Biol Med

PubMed ID: 35660523

Doi: 10.1016/j.freeradbiomed.2022.05.023

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Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2

Authors: Brandon Leonard, Kannan Sankar, Matthew G Romei, Margaret J Tse, Nina Do, Yanli Yang, Wadim L Matochko, Jack Bevers, Sundeep Bollineni, Kiran Mukhyala, Kam Hon Hoi, Greg A Lazar

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35653561

Doi: 10.1073/pnas.2201562119

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Persistence of immune responses to the Sinopharm/BBIBP-CorV vaccine

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Pradeep Darshana Pushpakumara, Achala Kamaladasa, Dinuka Guruge, Ayesha Wijesinghe, Banuri Gunasekera, Shyrar Tanussiya Ramu, Heshan Kuruppu, Thushali Ranasinghe, Shashika Dayarathna, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jeewantha Jayamali, Deshni Jayathilaka, Madushika Dissanayake, Tibutius Thanesh Jayadas, Anushika Mudunkotuwa, Gayasha Somathilake, Michael Harvie, Thashmi Nimasha, Saubhagya Danasekara, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K Tan, Tao Dong, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: Immun Inflamm Dis

PubMed ID: 35634958

Doi: 10.1002/iid3.621

Products & Services: Proteins, Expression, Isolation and Analysis

Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation

Authors: Julia E Page, Meredith A Skiba, Truc Do, Andrew C Kruse, Suzanne Walker

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35733252

Doi: 10.1073/pnas.2201141119

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Metabolic engineering of Yarrowia lipolytica for scutellarin production

Authors: Yina Wang , Xiaonan Liu , Bihuan Chen , Wei Liu , Zhaokuan Guo , Xiangyu Liu , Xiaoxi Zhu , Jiayu Liu , Jin Zhang , Jing Li , Lei Zhang , Yadi Gao , Guanghui Zhang , Yan Wang, M Iqbal Choudhary, Shengchao Yang , Huifeng Jiang

Journal: Synth Syst Biotechnol.

PubMed ID: 35756963

Doi: 10.1016/j.synbio.2022.05.009

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A chimeric MERS-CoV virus-like particle vaccine protects mice against MERS-CoV challenge

Authors: Jung-Eun Park, Ji-Hee Kim, Jae-Yeon Park, Sung-Hoon Jun, Hyun-Jin Shin

Journal: Virol J

PubMed ID: 35761402

Doi: 10.1186/s12985-022-01844-9

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Nuclear pore complex acetylation regulates mRNA export and cell cycle commitment in budding yeast

Authors: Mercè Gomar-Alba, Vasilisa Pozharskaia, Bogdan Cichocki, Celia Schaal, Arun Kumar, Basile Jacquel, Gilles Charvin, J Carlos Igual, Manuel Mendoza

Journal: EMBO J

PubMed ID: 35735140

Doi: 10.15252/embj.2021110271

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Extraoral expression and characterization of bitter taste receptors in (Mexican tetra fish)

Authors: Vikram Bhatia, Vivianne Cruz de Jesus, Feroz Ahmed Shaik, Appalaraju Jaggupilli, Nisha Singh, Prashen Chelikani, Devi Atukorallaya

Journal: FASEB Bioadv

PubMed ID: 36089978

Doi: 10.1096/fba.2022-00032

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A new Eimeria coccidian species (Apicomplexa: Eimeriidae) from Père David's deer (Elaphurus davidianus Milne-Edwards, 1866) in Dafeng Milu National Nature Reserve in Jiangsu Province, eastern China

Authors: Weimin Cai, Zeyang Suding, Lele Wang, Zhaofeng Hou, Dandan Liu, Siyang Huang, Jinjun Xu, Jianping Tao

Journal: BMC Vet Res

PubMed ID: 35655211

Doi: 10.1186/s12917-022-03308-2

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Cloning, expression, and one-step purification/immobilization of two carbohydrate-binding module-tagged alcohol dehydrogenases

Authors: Mario Benito, Ramón Román, Garazi Ortiz, Antoni Casablancas, Gregorio Álvaro, Gloria Caminal, Gloria González, Marina Guillén

Journal: J Biol Eng

PubMed ID: 35765016

Doi: 10.1186/s13036-022-00295-8

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Determination of the efficacy of using a serine protease gene as a DNA vaccine to protect against Vibrio parahaemolyticus infection in Litopenaeus vannamei

Authors: Naeem Madsari, Siriluk Maskaew, Sumalee Obchoei, Pattamaporn Kwankaew, Wilaiwan Senghoi, Prapaporn Utarabhand, Phanthipha Runsaeng

Journal: Dev Comp Immunol

PubMed ID: 35660488

Doi: 10.1016/j.dci.2022.104459

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Comparison of Selected Immune Parameters in a Single Infection and Co-Infection with Infectious Pancreatic Necrosis Virus with Other Viruses in Rainbow Trout

Authors: Joanna Maj-Paluch, Magdalena Wasiak, Łukasz Bocian, Michał Reichert

Journal: Pathogens

PubMed ID: 35745512

Doi: 10.3390/pathogens11060658

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Head-to-Head Comparison of 5 Anti-SARS-CoV-2 Assays Performance in One Hundred COVID-19 Vaccinees, over an 8-Month Course

Authors: Jakub Swadźba, Tomasz Anyszek, Andrzej Panek, Agnieszka Chojęta, Kinga Wyrzykowska, Emilia Martin

Journal: Diagnostics (Basel)

PubMed ID: 35741236

Doi: 10.3390/diagnostics12061426

Effect of Multivalency on Phase-Separated Droplets Consisting of Poly(PR) Dipeptide Repeats and RNA at the Solid/Liquid Interface

Authors: Chen Chen, Han Jia, Yoshiki Nakamura, Kohsuke Kanekura, Yuhei Hayamizu

Journal: ACS Omega

PubMed ID: 35721931

Doi: 10.1021/acsomega.2c00811

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Integrating In Vitro and In Silico Analysis of a Cationic Antimicrobial Peptide Interaction with Model Membranes of Colistin-Resistant Strains

Authors: Sandra Patricia Rivera-Sanchez, Iván Darío Ocampo-Ibáñez, Yamil Liscano, Natalia Martínez, Isamar Muñoz, Marcela Manrique-Moreno, Luis Martinez-Martinez, José Oñate-Garzon

Journal: Pharmaceutics

PubMed ID: 35745820

Doi: 10.3390/pharmaceutics14061248

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Template-Assisted Sequencing of SARS-CoV-2 and Influenza Monoclonal Antibodies by Mass Spectrometry

Authors: Michelle V Gadush, Giuseppe A Sautto, Hamssika Chandrasekaran, Alena Bensussan, Ted M Ross, Gregory C Ippolito, Maria D Person

Journal: J Proteome Res

PubMed ID: 35653804

Doi: 10.1021/acs.jproteome.1c00913

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Author Correction: Development of spirulina for the manufacture and oral delivery of protein therapeutics

Authors: Benjamin W Jester, Hui Zhao, Mesfin Gewe, Thomas Adame, Lisa Perruzza, David T Bolick, Jan Agosti, Nhi Khuong, Rolf Kuestner, Caitlin Gamble, Kendra Cruickshank, Jeremy Ferrara, Rachelle Lim, Troy Paddock, Colin Brady, Stacey Ertel, Miaohua Zhang, Alex Pollock, Jamie Lee, Jian Xiong, Michael Tasch, Tracy Saveria, David Doughty, Jacob Marshall, Damian Carrieri, Lauren Goetsch, Jason Dang, Nathaniel Sanjaya, David Fletcher, Anissa Martinez, Bryce Kadis, Kristjan Sigmar, Esha Afreen, Tammy Nguyen, Amanda Randolph, Alexandria Taber, Ashley Krzeszowski, Brittney Robinett, David B Volkin, Fabio Grassi, Richard Guerrant, Ryo Takeuchi, Brian Finrow, Craig Behnke, James Roberts

Journal: Nat Biotechnol

PubMed ID: 35440781

Doi: 10.1038/s41587-022-01323-0

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The Bufei Jianpi Formula Improves Mucosal Immune Function by Remodeling Gut Microbiota Through the SCFAs/GPR43/NLRP3 Pathway in Chronic Obstructive Pulmonary Disease Rats

Authors: Jing Mao, Ya Li, Qingqing Bian, Yinshuang Xuan, Jingmei Li, Zhikun Wang, Suxiang Feng, Xuefang Liu, Yange Tian, Suyun Li

Journal: Int J Chron Obstruct Pulmon Dis

PubMed ID: 35673595

Doi: 10.2147/COPD.S359428

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Time-dependent contraction of the SARS-CoV-2-specific T-cell responses in convalescent individuals

Authors: Edgar Ruz Fernandes, Juliana de Souza Apostolico, Lucas Cauê Jacintho, Maria Lucia Carnevale Marin, Roberto Carlos Vieira da Silva Júnior, Hélcio Rodrigues, Keity Souza Santos, Verônica Coelho, Silvia Beatriz Boscardin, Jorge Kalil, Edecio Cunha-Neto, Daniela Santoro Rosa

Journal: J Allergy Clin Immunol Glob

PubMed ID: 36203479

Doi: 10.1016/j.jacig.2022.05.002

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Structure and Protein-Protein Interactions of Ice Nucleation Proteins Drive Their Activity

Authors: Susan Hartmann, Meilee Ling, Lasse S A Dreyer, Assaf Zipori, Kai Finster, Sarah Grawe, Lasse Z Jensen, Stella Borck, Naama Reicher, Taner Drace, Dennis Niedermeier, Nykola C Jones, Søren V Hoffmann, Heike Wex, Yinon Rudich, Thomas Boesen, Tina Šantl-Temkiv

Journal: Front Microbiol

PubMed ID: 35783412

Doi: 10.3389/fmicb.2022.872306

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of Chemical Probes Targeting MBD2

Authors: Diane Erdmann, Jean Contreras, Rémy A Le Meur, Bruno Vitorge, Vincent Saverat, Ambre Tafit, Corinne Jallet, Véronique Cadet-Daniel, Corentin Bon, Phannarath Phansavath, Virginie Ratovelomanana-Vidal, Albert Jeltsch, Sophie Vichier-Guerre, J Iñaki Guijarro, Paola B Arimondo

Journal: ACS Chem Biol

PubMed ID: 35649238

Doi: 10.1021/acschembio.1c00959

Products & Services: Proteins, Expression, Isolation and Analysis

Antibody-based redirection of universal Fabrack-CAR T cells selectively kill antigen bearing tumor cells

Authors: Yi-Chiu Kuo, Cheng-Fu Kuo, Kurt Jenkins, Alfur Fu-Hsin Hung, Wen-Chung Chang, Miso Park, Brenda Aguilar, Renate Starr, Jonathan Hibbard, Christine Brown, John C Williams

Journal: J Immunother Cancer

PubMed ID: 35728874

Doi: 10.1136/jitc-2021-003752

Products & Services: Proteins, Expression, Isolation and Analysis

Autoimmune neuroinflammation triggers mitochondrial oxidation in oligodendrocytes

Authors: Jasmin Steudler, Timothy Ecott, Daniela C Ivan, Elisa Bouillet, Sabrina Walthert, Kristina Berve, Tobias P Dick, Britta Engelhardt, Giuseppe Locatelli

Journal: Glia

PubMed ID: 35762739

Doi: 10.1002/glia.24235

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Improved yield of recombinant human IFN-α2b from mammalian cells using heterologous signal peptide approach

Authors: Claire Wilkinson, Jacob Kyle, Meghna Irimpen, Sarah Stuart, Shylaja Mohandass, Andrew Sheperd, Kathrine J Smith, Michael J Mullin

Journal: Protein Expr Purif

PubMed ID: 35659600

Doi: 10.1016/j.pep.2022.106125

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Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening

Authors: Rui Zheng, Wenhao Yang, Yuting Wen, Liang Xie, Fang Shi, Danli Lu, Jiaxin Luo, Yan Li, Rui Zhang, Ting Chen, Lina Chen, Wenming Xu, Hanmin Liu

Journal: Cell Death Dis

PubMed ID: 35729109

Doi: 10.1038/s41419-022-05010-5

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 Neutralizing Antibodies Kinetics Postvaccination in Cancer Patients under Treatment with Immune Checkpoint Inhibition

Authors: Evangelos Terpos, Michalis Liontos, Oraianthi Fiste, Flora Zagouri, Alexandros Briasoulis, Aimilia D Sklirou, Christos Markellos, Efthymia Skafida, Alkistis Papatheodoridi, Angeliki Andrikopoulou, Konstantinos Koutsoukos, Maria Kaparelou, Vassiliki A Iconomidou, Ioannis P Trougakos, Meletios-Athanasios Dimopoulos

Journal: Cancers (Basel)

PubMed ID: 35681774

Doi: 10.3390/cancers14112796

Vaccination after SARS-CoV-2 infection increased antibody avidity against the Omicron variant compared to vaccination alone

Authors: Cas LeMaster, Eric S Geanes, Elizabeth R Fraley, Rangaraj Selvarangan, Todd Bradley

Journal: J Infect Dis

PubMed ID: 35714328

Doi: 10.1093/infdis/jiac247

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Investigation of Product Ions Generated by 193 nm Ultraviolet Photodissociation of Peptides and Proteins Containing Disulfide Bonds

Authors: Luis A Macias, Jennifer S Brodbelt

Journal: J Am Soc Mass Spectrom