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Comparison of the immunogenicity of five COVID-19 vaccines in Sri Lanka

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Saubhagya Danasekara, Laksiri Gomes, Suranga Fernando, Dinuka Guruge, Thushali Ranasinghe, Banuri Gunasekera, Achala Kamaladasa, Heshan Kuruppu, Gayasha Somathilake, Jeewantha Jayamali, Deshni Jayathilaka, Helanka Dinesh Kumara Wijayatilake, Pradeep Darshana Pushpakumara, Michael Harvie, Thashmi Nimasha, Shiromi Devika Grace de Silva, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Jack Tan, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: Immunology

PubMed ID: 35751563

Doi: 10.1111/imm.13535

Products & Services: Recombinant Antibody Expression

Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins

Authors: David Moi, Shunsuke Nishio, Xiaohui Li, Clari Valansi, Mauricio Langleib, Nicolas G Brukman, Kateryna Flyak, Christophe Dessimoz, Daniele de Sanctis, Kathryn Tunyasuvunakool, John Jumper, Martin Graña, Héctor Romero, Pablo S Aguilar, Luca Jovine, Benjamin Podbilewicz

Journal: Nat Commun

PubMed ID: 35794124

Doi: 10.1038/s41467-022-31564-1

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A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes

Authors: Khyati Girdhar, Qian Huang, I-Ting Chow, Tommi Vatanen, Claudia Brady, Amol Raisingani, Patrick Autissier, Mark A Atkinson, William W Kwok, C Ronald Kahn, Emrah Altindis

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35878027

Doi: 10.1073/pnas.2120028119

Products & Services: Proteins, Expression, Isolation and Analysis

Anti-Ischemic Effects of PIK3IP1 Are Mediated through Its Interactions with the ET-PI3Kγ-AKT Axis

Authors: Jei Hyoung Park, Kyoung Jin Nho, Ji Young Lee, Yung Joon Yoo, Woo Jin Park, Chunghee Cho, Do Han Kim

Journal: Cells

PubMed ID: 35883611

Doi: 10.3390/cells11142162

Products & Services: Custom Vector Construction

Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission

Authors: Sash Lopaticki, Robyn McConville, Alan John, Niall Geoghegan, Shihab Deen Mohamed, Lisa Verzier, Ryan W J Steel, Cindy Evelyn, Matthew T O'Neill, Niccolay Madiedo Soler, Nichollas E Scott, Kelly L Rogers, Ethan D Goddard-Borger, Justin A Boddey

Journal: Nat Commun

PubMed ID: 35906227

Doi: 10.1038/s41467-022-32076-8

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Inactive and active state structures template selective tools for the human 5-HT receptor

Authors: Shicheng Zhang, He Chen, Chengwei Zhang, Ying Yang, Petr Popov, Jing Liu, Brian E Krumm, Can Cao, Kuglae Kim, Yan Xiong, Vsevolod Katritch, Brian K Shoichet, Jian Jin, Jonathan F Fay, Bryan L Roth

Journal: Nat Struct Mol Biol

PubMed ID: 35835867

Doi: 10.1038/s41594-022-00796-6

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 Delta spike protein enhances the viral fusogenicity and inflammatory cytokine production

Authors: Zhujun Ao, Maggie Jing Ouyang, Titus Abiola Olukitibi, Xiaojian Yao

Journal: iScience

PubMed ID: 35854977

Doi: 10.1016/j.isci.2022.104759

Products & Services: Plasmid DNA Preparation

gC1qR/C1qBP/HABP-1: Structural Analysis of the Trimeric Core Region, Interactions With a Novel Panel of Monoclonal Antibodies, and Their Influence on Binding to FXII

Authors: Ying Zhang, Alexander J Vontz, Ethan M Kallenberger, Xin Xu, Nicoleta T Ploscariu, Kasra X Ramyar, Brandon L Garcia, Berhane Ghebrehiwet, Brian V Geisbrecht

Journal: Front Immunol

PubMed ID: 35865516

Doi: 10.3389/fimmu.2022.887742

Products & Services: Mammalian Expression

Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected Individuals

Authors: Zehra Karakoese, Mara Schwerdtfeger, Christina B Karsten, Stefan Esser, Ulf Dittmer, Kathrin Sutter

Journal: Front Immunol

PubMed ID: 35911692

Doi: 10.3389/fimmu.2022.936918

Products & Services: Mammalian Expression

Orphan nuclear receptor NUR77 relieves insulin resistance in HTR-8/SVneo trophoblast cells through activation of autophagy and insulin signaling

Authors: Ling Li, Yu Bai, Runyu Du, Lei Tang, Ling Li

Journal: J Physiol Biochem

PubMed ID: 35902547

Doi: 10.1007/s13105-022-00901-9

Products & Services: Proteins, Expression, Isolation and Analysis

Transcriptional response to VZV infection is modulated by RNA polymerase III in lung epithelial cell lines

Authors: Brianna M Doratt, Elizabeth Vance, Delphine C Malherbe, Mark T W Ebbert, Ilhem Messaoudi

Journal: Front Cell Infect Microbiol

PubMed ID: 35959363

Doi: 10.3389/fcimb.2022.943587

Products & Services: Proteins, Expression, Isolation and Analysis

Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter

Authors: Deepthi Joseph, Smruti Ranjan Nayak, Aravind Penmatsa

Journal: EMBO J

PubMed ID: 35796008

Doi: 10.15252/embj.2022110735

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A recombinant VSV-vectored vaccine rapidly protects nonhuman primates against heterologous lethal Lassa fever

Authors: Robert W Cross, Courtney Woolsey, Abhishek N Prasad, Viktoriya Borisevich, Krystle N Agans, Daniel J Deer, Joan B Geisbert, Natalie S Dobias, Karla A Fenton, Thomas W Geisbert

Journal: Cell Rep

PubMed ID: 35858566

Doi: 10.1016/j.celrep.2022.111094

Products & Services: Peptide Synthesis

Low molecular weight fucoidan alleviates cerebrovascular damage by promoting angiogenesis in type 2 diabetes mice

Authors: Zhi Li, Ning Wu, Jing Wang, Yang Yue, Lihua Geng, Quanbin Zhang

Journal: Int J Biol Macromol

PubMed ID: 35841956

Doi: doi.org/10.1016/j.ijbiomac.2022.07.053

Products & Services: Proteins, Expression, Isolation and Analysis

Structural insight into apelin receptor-G protein stoichiometry

Authors: Yang Yue , Lier Liu , Li-Jie Wu , Yiran Wu , Ling Wang , Fei Li , Junlin Liu , Gye-Won Han , Bo Chen , Xi Lin , Rebecca L Brouillette , Émile Breault , Jean-Michel Longpré , Songting Shi , Hui Lei , Philippe Sarret , Raymond C Stevens , Michael A Hanson , Fei Xu

Journal: Nat Struct Mol Biol

PubMed ID: 35817871

Doi: 10.1038/s41594-022-00797-5

Products & Services: Peptide Synthesis

Endothelial PHD2 deficiency induces nitrative stress suppression of caveolin-1 in pulmonary hypertension

Authors: Bin Liu, Yi Peng, Dan Yi, Narsa Machireddy, Daoyin Dong, Karina Ramirez, Jingbo Dai, Rebecca Vanderpool, Maggie M Zhu, Zhiyu Dai, You-Yang Zhao

Journal: Eur Respir J

PubMed ID: 35798360

Doi: 10.1183/13993003.02643-2021

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Purification, characterization, and preliminary serial crystallography diffraction advances structure determination of full-length human particulate guanylyl cyclase A receptor

Authors: Shangji Zhang, Debra T Hansen, Jose M Martin-Garcia, James D Zook, Shuchong Pan, Felicia M Craciunescu, John C Burnett, Petra Fromme

Journal: Sci Rep

PubMed ID: 35821229

Doi: 10.1038/s41598-022-15798-z

Products & Services: Insect Expression

Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes.

Authors: Uxue Ballesteros , Asier Etxaniz , Marina N Iriondo , Yaiza R Varela , Melisa Lázaro , Ana R Viguera , L Ruth Montes , Mikel Valle , Félix M Goñi , Alicia Alonso

Journal: Int J Biol Macromol

PubMed ID: 35618088

Doi: 10.1016/j.ijbiomac.2022.05.129.

Products & Services: Mutagenesis Services

Heterologous mRNA vaccine booster increases neutralization of SARS-CoV-2 Omicron BA.2 variant

Authors: Gen Li , Zhongcheng Zhou , Peng Du , Meixiao Zhan , Ning Li 1、, Xinxin Xiong , Shengjun Tang , Miao Man, Daniel T Baptista-Hon, Ligong Lu

Journal: Signal Transduct Target Ther

PubMed ID: 35853864

Doi: 10.1038/s41392-022-01062-3.

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Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions

Authors: Xingxing Li , Liuqing He , Jianhua Luo , Yangling Zheng , Yao Zhou , Danyang Li , Yuanyuan Zhang , Zhenrui Pan , Yanyan Li , Liang Tao

Journal: Nat Commun

PubMed ID: 35882856

Doi: 10.1038/s41467-022-31994-x

Products & Services: Gene Synthesis Monoclonal Antibody Services

Effective Functional Immunogenicity of a DNA Vaccine Combination Delivered via In Vivo Electroporation Targeting Malaria Infection and Transmission

Authors: Yi Cao , Clifford T H Hayashi , Fidel Zavala , Abhai K Tripathi , Hayk Simonyan , Colin N Young , Leor C Clark , Yukari Usuda , Jacob M Van Parys , Nirbhay Kumar

Journal: Vaccines (Basel)

PubMed ID: 35891298

Doi: 10.3390/vaccines10071134

Products & Services: Plasmid DNA Preparation

One-pot isothermal LAMP-CRISPR-based assay for Klebsiella pneumoniae detection

Authors: Xiaotong Qiu , Xueping Liu , Xiao Ma , Ruixue Wang , Shenglin Chen , Fang Li , Zhenjun Li

Journal: Microbiol Spectr

PubMed ID: 35856669

Doi: 10.1128/spectrum.01545-22

Products & Services: Synthetic sgRNA and crRNA Service

Direct adenylation from 5?-OH-terminated oligonucleotides by a fusion enzyme containing Pfu RNA ligase and T4 polynucleotide kinase

Authors: Zhengquan Yang , Chengliang Zhang , Guojun Lian , Shijie Dong , Menghui Song , Hengrong Shao , Jingmei Wang , Tao Zhong , Zhenni Luo , Shengnan Jin , Chunming Ding

Journal: Nucleic Acids Res

PubMed ID: 35819229

Doi: org/10.1093/nar/gkac604

Products & Services: Custom DNA/RNA Oligos

Structural insights into the activation of neurokinin 2 receptor by neurokinin A

Authors: Wenjing Sun , Qingning Yuan , Huanhuan Zhang , Fan Yang , Shenglong Ling , Yifan Luo , Pei Lv , H Eric Xu , Changlin Tian , Wanchao Yin , Pan Shi

Journal: Cell Discov

PubMed ID: 35882833

Doi: 10.1038/s41421-022-00437-8

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Discrimination between Different DNA Lesions by Monitoring Single-Molecule Polymerase Stalling Kinetics during Nanopore Sequencing

Authors: Jinyue Zhang , Yu Wang , Yuqin Wang , Panke Zhang , Hong-Yuan Chen , Shuo Huang

Journal: Nano Lett

PubMed ID: 35713465

Doi: 10.1021/acs.nanolett.2c01833

Products & Services: Custom DNA/RNA Oligos

Generation of a Soluble African Horse Sickness Virus VP7 Protein Capable of Forming Core-like Particles

Authors: Shani Bekker, Henk Huismans, Vida van Staden

Journal: Viruses

PubMed ID: 35893692

Doi: 10.3390/v14081624

Products & Services: Polyclonal Antibody Services

Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance

Authors: Xinlei Zhuang, Zhe Wang, Jiansheng Fan, Xuefei Bai, Yingchun Xu, James J Chou, Tingjun Hou, Shuqing Chen, Liqiang Pan

Journal: Nat Commun

PubMed ID: 35907884

Doi: 10.1038/s41467-022-32159-6

Products & Services: Polyclonal Antibody Services

Effects of SPA4 peptide on lipopolysaccharide-disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury

Authors: Asif Alam Chowdhury, Nachiket M Godbole, Neha Chataut, Stanley Kosanke, Karla Rodgers, Shanjana Awasthi

Journal: Physiol Rep

PubMed ID: 35838161

Doi: 10.14814/phy2.15353

Products & Services: Peptide Synthesis

Humanin derivative, HNG, enhances neurotransmitter release

Authors: Natsumi Ikegawa, Ayari Kozuka, Nozomi Morita, Minetaka Murakami, Nobuyuki Sasakawa, Takako Niikura

Journal: Biochim Biophys Acta Gen Subj

PubMed ID: 35843407

Doi: 10.1016/j.bbagen.2022.130204

Products & Services: Endotoxin Detection & Removal System

Development of a Multi-Epitope Vaccine for and Evaluation of Its Immune Responses in Mice and Piglets

Authors: Gaojian Li, Jinqi Shu, Jing Jin, Jianhong Shu, Huapeng Feng, Jian Chen, Yulong He

Journal: Int J Mol Sci

PubMed ID: 35887246

Doi: 10.3390/ijms23147899

Products & Services: Codon Optimization

BioWF: A Naturally-Fused, Di-Domain Biocatalyst from Biotin Biosynthesis Displays an Unexpectedly Broad Substrate Scope

Authors: Shona M Richardson, Peter J Harrison, Michael A Herrera, Menglu Wang, Rebecca Verez, Gustavo Perez Ortiz, Dominic J Campopiano

Journal: Chembiochem

PubMed ID: 35695820

Doi: 10.1002/cbic.202200171

Products & Services: Plasmid DNA Preparation

A cell-free paper-based biosensor dependent on allosteric transcription factors (aTFs) for on-site detection of harmful metals Hg and Pb in water

Authors: Yongkang Zhang, Chen Zhao, Huaixiu Bi, Xi Zhang, Bin Xue, Chenyu Li, Shang Wang, Xiaobo Yang, Zhigang Qiu, Jingfeng Wang, Zhiqiang Shen

Journal: J Hazard Mater

PubMed ID: 35816794

Doi: 10.1016/j.jhazmat.2022.129499

Products & Services: Plasmid DNA Preparation

PLAA suppresses ovarian cancer metastasis via METTL3-mediated mA modification of TRPC3 mRNA

Authors: Zhangjin Shen, Lingkai Gu, Yuwan Liu, Lingfang Wang, Jiawei Zhu, Sangsang Tang, Xinyi Wei, Jiaying Wang, Songfa Zhang, Xinyu Wang, Xiaodong Cheng, Xing Xie, Weiguo Lu

Journal: Oncogene

PubMed ID: 35869392

Doi: 10.1038/s41388-022-02411-w

Products & Services: Proteins, Expression, Isolation and Analysis

Membrane Permeabilization and Antimicrobial Activity of Recombinant Defensin-d2 and Actifensin against Multidrug-Resistant and

Authors: Ifeoluwa D Gbala, Rosaline W Macharia, Joel L Bargul, Gabriel Magoma

Journal: Molecules

PubMed ID: 35889198

Doi: 10.3390/molecules27144325

Products & Services: Plasmid DNA Preparation

Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells

Authors: Dave Francisco, Ying Wang, Craig Marshall, Michelle Conway, Kenneth J Addison, Dean Billheimer, Hiroki Kimura, Mari Numata, Hong W Chu, Dennis R Voelker, Monica Kraft, Julie G Ledford

Journal: Front Immunol

PubMed ID: 35874703

Doi: 10.3389/fimmu.2022.900022

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Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis

Authors: Clint M Upchurch, Scott Yeudall, Caitlin M Pavelec, Dennis Merk, Jan Greulich, Mohan Manjegowda, Shyam S Raghavan, Irina M Bochkis, Michael M Scott, Edward Perez-Reyes, Norbert Leitinger

Journal: Sci Adv

PubMed ID: 35857497

Doi: 10.1126/sciadv.abn0050

Products & Services: Gene Synthesis

A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis

Authors: Namrata Bora-Singhal, Biswarup Saha, Durairaj Mohankumar, Jaya Padmanabhan, Domenico Coppola, Srikumar Chellappan

Journal: Cancer Res Commun

PubMed ID: 35937460

Doi: 10.1158/2767-9764.crc-21-0084

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Assessment of neutralizing antibody responses after natural SARS-CoV-2 infection and vaccination in congolese individuals

Authors: Armel Landry Batchi-Bouyou, Jean Claude Djontu, Jeannhey Christevy Vouvoungui, Claujens Chastel Mfoutou Mapanguy, Line Lobaloba Ingoba, Jiré Séphora Mougany, Kamal Rauchelvy Boumpoutou, Steve Diafouka-Kietela, Raoul Ampa, Francine Ntoumi

Journal: BMC Infect Dis

PubMed ID: 35831798

Doi: 10.1186/s12879-022-07593-y

Products & Services: Recombinant Proteins

The two-domain elevator-type mechanism of zinc-transporting ZIP proteins

Authors: Anders Wiuf, Jonas Hyld Steffen, Eva Ramos Becares, Christina Grønberg, Dhani Ram Mahato, Søren G F Rasmussen, Magnus Andersson, Tristan Croll, Kamil Gotfryd, Pontus Gourdon

Journal: Sci Adv

PubMed ID: 35857505

Doi: 10.1126/sciadv.abn4331

Products & Services: Mutagenesis Services

Development of Highly Sensitive Sandwich ELISA for the Early-Phase Diagnosis of Chikungunya Virus Utilizing rE2-E1 Protein

Authors: Mohammad Islamuddin, Abuzer Ali, Wajihul Hasan Khan, Amena Ali, Syed Kazim Hasan, Mohd Abdullah, Kentaro Kato, Malik Zainul Abdin, Shama Parveen

Journal: Infect Drug Resist

PubMed ID: 35924014

Doi: 10.2147/IDR.S347545

Products & Services: Gene Synthesis

Cutting Edge: Promoting T Cell Factor 1 T Cell Self-Renewal to Improve Programmed Cell Death Protein 1 Blockade

Authors: Peter H Wang, Robert Washburn, Rohan Maniar, Michael Mu, Olivia Ringham, Radomir Kratchmarov, Brian S Henick, Steven L Reiner

Journal: J Immunol

PubMed ID: 35905999

Doi: 10.4049/jimmunol.2200317

Products & Services: Mammalian Expression

Proteomic Network of Antibiotic-Induced Outer Membrane Vesicles Released by Extensively Drug-Resistant Elizabethkingia anophelis

Authors: Ming-Hsien Chiang, Fang-Ju Chang, Dinesh Kumar Kesavan, Aparna Vasudevan, Huaxi Xu, Kuo-Lun Lan, Shu-Wei Huang, Hung-Sheng Shang, Yi-Ping Chuang, Ya-Sung Yang, Te-Li Chen

Journal: Microbiol Spectr

PubMed ID: 35852325

Doi: 10.1128/spectrum.00262-22

Products & Services: Bacterial Expression

HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics

Authors: Matthew D Surette, Nicholas Waglechner, Kalinka Koteva, Gerard D Wright

Journal: Mol Cell

PubMed ID: 35907401

Doi: 10.1016/j.molcel.2022.06.019

Products & Services: Proteins, Expression, Isolation and Analysis

Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal

Authors: Huiyun Liu, Daniel Heller-Trulli, Claire L Moore

Journal: iScience

PubMed ID: 35992060

Doi: 10.1016/j.isci.2022.104804

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Combined strategies for suppressing nonspecific cationic adduction to G-quadruplexes in electrospray ionization mass spectrometry

Authors: Wen Lei, Jun Hu, Hong-Yuan Chen, Jing-Juan Xu

Journal: Anal Chim Acta

PubMed ID: 35868693

Doi: 10.1016/j.aca.2022.340146

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Optimized peptide extraction method for analysis of antimicrobial peptide Kn2-7/dKn2-7 stability in human serum by LC-MS

Authors: Wen Chen, Dickson Kirui, Nancy J Millenbaugh

Journal: Future Sci OA

PubMed ID: 35909998

Doi: 10.2144/fsoa-2022-0013

Products & Services: Recombinant Proteins

CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1

Authors: Yixuan Lu, Yongxin Mu, Ju Chen, Xinyuan Guan, Ling Guo, Chuanyue Wu

Journal: Theranostics

PubMed ID: 35836803

Doi: 10.7150/thno.72365

Products & Services: Recombinant Proteins

A multiple-target mRNA-LNP vaccine induces protective immunity against experimental multi-serotype DENV in mice

Authors: Lihong He, Wenqiang Sun, Limin Yang, Wenjun Liu, Jing Li

Journal: Virol Sin

PubMed ID: 35835315

Doi: 10.1016/j.virs.2022.07.003

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Comparing methods for immobilizing HIV-1 SOSIPs in ELISAs that evaluate antibody binding

Authors: Kim-Marie A Dam, Patricia S Mutia, Pamela J Bjorkman

Journal: Sci Rep

PubMed ID: 35778473

Doi: 10.1038/s41598-022-15506-x

Products & Services: Mammalian Expression

A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding

Authors: Brooke D Huisman, Zheng Dai, David K Gifford, Michael E Birnbaum

Journal: Elife

PubMed ID: 35781135

Doi: 10.7554/eLife.78589

Products & Services: Recombinant Antibody Expression

Pneumolysin suppresses the initial macrophage pro-inflammatory response to Streptococcus pneumoniae

Authors: Jimstan Periselneris, Carolin T Turner, Giuseppe Ercoli, Gabriella Szylar, Caroline M Weight, Teresa Thurston, Matthew Whelan, Gillian Tomlinson, Mahdad Noursadeghi, Jeremy Brown

Journal: Immunology

PubMed ID: 35835695

Doi: 10.1111/imm.13546

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Evaluation of residue variability in a conformation-specific context and during evolutionary sequence reconstruction narrows drug resistance selection in Abl1 tyrosine kinase

Authors: Felipe A M Otsuka, Sinisa Bjelic

Journal: Protein Sci

PubMed ID: 35762721

Doi: 10.1002/pro.4354

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Connexin 43 overexpression induces lung cancer angiogenesis following phosphorylation at Ser279 in its C-terminus

Authors: Zizi Zhou, Wenxiang Chai, Yi Liu, Yao Liu, Huiyu Pan, Qiang Wu, Xiaoming Zhang

Journal: Oncol Lett

PubMed ID: 35949588

Doi: 10.3892/ol.2022.13413

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Differences in Linear Epitopes of Ara h 9 Recognition in Peanut Allergic and Tolerant, Peach Allergic Patients

Authors: L Sánchez-Ruano, C Fernández-Lozano, M Ferrer, F Gómez, B de la Hoz, J Martínez-Botas, M J Goikoetxea

Journal: Front Allergy

PubMed ID: 35935018

Doi: 10.3389/falgy.2022.896617

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Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ

Authors: Qian Zhou, Wan-Wan Sun, Jia-Cong Chen, Hui-Lu Zhang, Jie Liu, Yan Lin, Peng-Cheng Lin, Bai-Xing Wu, Yan-Peng An, Lin Huang, Wen-Xing Sun, Xin-Wen Zhou, Yi-Ming Li, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao

Journal: Nat Commun

PubMed ID: 35879296

Doi: 10.1038/s41467-022-32000-0

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Cap Is the Protease of the Porcine Circovirus 2

Authors: Xuechen Yang, Wei Yang, Wei Zhang, Jiamei Li, Guoyu Yang, Shuhong Zhao, Yueting Zheng

Journal: Viruses

PubMed ID: 35891530

Doi: 10.3390/v14071550

Products & Services: Proteins, Expression, Isolation and Analysis

A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins

Authors: Noureddine Lazar, Carl H Mesarich, Yohann Petit-Houdenot, Nacera Talbi, Ines Li de la Sierra-Gallay, Emilie Zélie, Karine Blondeau, Jérôme Gracy, Bénédicte Ollivier, Françoise Blaise, Thierry Rouxel, Marie-Hélène Balesdent, Alexander Idnurm, Herman van Tilbeurgh, Isabelle Fudal

Journal: PLoS Pathog

PubMed ID: 35793393

Doi: 10.1371/journal.ppat.1010664

Products & Services: Proteins, Expression, Isolation and Analysis

Phase transition modulation and biophysical characterization of biomolecular condensates using microfluidics

Authors: Katherine W Y Chan, Maryam Navi, Jennifer Kieda, Thomas Moran, Daniel Hammers, Shaun Lee, Scott S H Tsai

Journal: Lab Chip

PubMed ID: 35616128

Doi: 10.1039/d2lc00037g

Products & Services: Proteins, Expression, Isolation and Analysis

Theaflavin-3,3'-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells

Authors: Yichen Wu, Min Chen, Zilong Chen, Jiangcheng Shu, Luoying Zhang, Jiong Hu, Hongjun Yu, Kai Huang, Minglu Liang

Journal: Front Pharmacol

PubMed ID: 35903325

Doi: 10.3389/fphar.2022.861319

Products & Services: Recombinant Proteins

CROWN ROOTLESS1 binds DNA with a relaxed specificity and activates OsROP and OsbHLH044 genes involved in crown root formation in rice

Authors: Mathieu Gonin, Kwanho Jeong, Yoan Coudert, Jeremy Lavarenne, Giang Thi Hoang, Martine Bes, Huong Thi Mai To, Marie-Rose Ndella Thiaw, Toan Van Do, Daniel Moukouanga, Soazig Guyomarc'h, Kevin Bellande, Jean-Rémy Brossier, Boris Parizot, Hieu Trang Nguyen, Tom Beeckman, Véronique Bergougnoux, Jacques Rouster, Christophe Sallaud, Laurent Laplaze, Antony Champion, Pascal Gantet

Journal: Plant J

PubMed ID: 35596715

Doi: 10.1111/tpj.15838

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Mining Amphibian and Insect Transcriptomes for Antimicrobial Peptide Sequences with rAMPage

Authors: Diana Lin, Darcy Sutherland, Sambina Islam Aninta, Nathan Louie, Ka Ming Nip, Chenkai Li, Anat Yanai, Lauren Coombe, René L Warren, Caren C Helbing, Linda M N Hoang, Inanc Birol

Journal: Antibiotics (Basel)

PubMed ID: 35884206

Doi: 10.3390/antibiotics11070952

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Cross-variant protection against SARS-CoV-2 infection in hamsters immunized with monovalent and bivalent inactivated vaccines

Authors: Zi-Wei Ye, Yilan Fan, Kaiming Tang, Chon Phin Ong, Cuiting Luo, Hon-Lam Chung, Tsun-Lam Leong, Ronghui Liang, Wai-Yin Lui, Runhong Zhou, Yun Cheng, Lu Lu, Pak-Hin Hinson Cheung, Jasper Fuk-Woo Chan, Zhiwei Chen, Kwok-Yung Yuen, Shuofeng Yuan, Kelvin Kai-Wang To, Dong-Yan Jin

Journal: Int J Biol Sci

PubMed ID: 35874942

Doi: 10.7150/ijbs.72109

Biglycan neo-epitope (BGN), a novel biomarker for screening early changes in equine osteoarthritic subchondral bone

Authors: S Adepu, S Ekman, J Leth, U Johansson, A Lindahl, E Skiöldebrand

Journal: Osteoarthritis Cartilage

PubMed ID: 35870736

Doi: 10.1016/j.joca.2022.07.005

Products & Services: Proteins, Expression, Isolation and Analysis

Comparative analysis of human immune responses following SARS-CoV-2 vaccination with BNT162b2, mRNA-1273, or Ad26COV2S

Authors: Dominique J Barbeau, Judith M Martin, Emily Carney, Emily Dougherty, Joshua D Doyle, Terence S Dermody, Alejandro Hoberman, John V Williams, Marian G Michaels, John F Alcorn, W Paul Duprex, Anita K McElroy

Journal: npj Vaccines

PubMed ID: 35794181

Doi: 10.1038/s41541-022-00504-x

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FOXM1 regulates glycolysis and energy production in multiple myeloma

Authors: Yan Cheng, Fumou Sun, Krista Thornton, Xuefang Jing, Jing Dong, Grant Yun, Michael Pisano, Fenghuang Zhan, Sung Hoon Kim, John A Katzenellenbogen, Benita S Katzenellenbogen, Parameswaran Hari, Siegfried Janz

Journal: Oncogene

PubMed ID: 35794249

Doi: 10.1038/s41388-022-02398-4

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Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a live biotherapeutic for phenylketonuria

Authors: Yu Jiang, Bingbing Sun, Fenghui Qian, Feng Dong, Chongmao Xu, Wuling Zhong, Rui Huang, Qiwei Zhai, Yu Jiang, Sheng Yang

Journal: Sci China Life Sci

PubMed ID: 35907113

Doi: 10.1007/s11427-021-2137-3

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Microfluidic Paper-Based Preconcentration and Retrieval for Rapid Ribonucleic Acid Biomarker Detection and Visualization

Authors: Yannan Yu, Fengya Fan, Zachary J Smith, Xi Wei

Journal: Anal Chem

PubMed ID: 35858837

Doi: 10.1021/acs.analchem.2c01442

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Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster model

Authors: Kyle Rosenke, Atsushi Okumura, Matthew C Lewis, Friederike Feldmann, Kimberly Meade-White, W Forrest Bohler, Amanda Griffin, Rebecca Rosenke, Carl Shaia, Michael A Jarvis, Heinz Feldmann

Journal: JCI Insight

PubMed ID: 35579953

Doi: 10.1172/jci.insight.160108

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HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS

Authors: Elke Braems, Valérie Bercier, Evelien Van Schoor, Kara Heeren, Jimmy Beckers, Laura Fumagalli, Lieselot Dedeene, Matthieu Moisse, Ilse Geudens, Nicole Hersmus, Arpan R Mehta, Bhuvaneish T Selvaraj, Siddharthan Chandran, Ritchie Ho, Dietmar R Thal, Philip Van Damme, Bart Swinnen, Ludo Van Den Bosch

Journal: Acta Neuropathol

PubMed ID: 35895140

Doi: 10.1007/s00401-022-02471-y

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KIL1 terminates fertility in maize by controlling silk senescence

Authors: M Ria Šim Škov, Anna Daneva, Nicolas Doll, Neeltje Schilling, Marta Cubr A-Rad O, Liangzi Zhou, Freya De Winter, Stijn Aesaert, Riet De Rycke, Laurens Pauwels, Thomas Dresselhaus, Norbert Brugi Re, Carl R Simmons, Jeffrey E Habben, Moritz K Nowack

Journal: Plant Cell

PubMed ID: 35608197

Doi: 10.1093/plcell/koac151

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The structure of Vibrio cholerae FeoC reveals conservation of the helix-turn-helix motif but not the cluster-binding domain

Authors: Janae B Brown, Mark A Lee, Aaron T Smith

Journal: J Biol Inorg Chem

PubMed ID: 35796835

Doi: 10.1007/s00775-022-01945-4

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Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma

Authors: Ryan J Boyd, Tien L Olson, James D Zook, Derek Stein, Manuel Aceves, Wan-Hsin Lin, Felicia M Craciunescu, Debra T Hansen, Panos Z Anastasiadis, Abhishek Singharoy, Petra Fromme

Journal: FASEB J

PubMed ID: 35639414

Doi: 10.1096/fj.202101808RR

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Optimization and validation of CAR transduction into human primary NK cells using CRISPR and AAV

Authors: Meisam Naeimi Kararoudi, Shibi Likhite, Ezgi Elmas, ..., Branden S. Moriarity, Kathrin Meyer, Dean A. Lee

Journal: CellPress

Doi: crmeth.2022.100236

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Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway.

Authors: Shenglong Zhu, Jingwei Zhang, Xuan Jiang, Wei Wang, Yong Q Chen

Journal: EBioMedicine

PubMed ID: 35588628

Doi: 10.1016/j.ebiom.2022.104060

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Agrochemical control of gene expression using evolved split RNA polymerase

Authors: Yuan Yuan , Jin Miao

Journal: PeerJ

PubMed ID: 35729907

Doi: doi.org/10.7717/peerj.13619

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Nociceptor Neurons are Involved in the Host Response to Urinary Tract Infections

Authors: Zhengdong Gao, Yaxiao Liu, Lekai Zhang, Zizhuo Yang, Linchen Lv, Shuai Wang, Lipeng Chen, Nan Zhou, Yaofeng Zhu, Xuewen Jiang, Benkang Shi, Yan Li

Journal: J Inflamm Res

PubMed ID: 35702548

Doi: 10.2147/JIR.S356960

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Humoral and Cellular Responses to BNT162b2 as a Booster Following Two Doses of ChAdOx1 nCov-19 Determined Using Three SARS-CoV-2 Antibody Assays and an Interferon-Gamma Release Assay: A Prospective Longitudinal Study in Healthcare Workers

Authors: Seri Jeong, Nuri Lee, Su Kyung Lee, Eun-Jung Cho, Jungwon Hyun, Min-Jeong Park, Wonkeun Song, Hyun Soo Kim

Journal: Front Immunol

PubMed ID: 35720318

Doi: 10.3389/fimmu.2022.859019

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Using field evaluation and systematic iteration to rationalize the accumulation of omega-3 long-chain polyunsaturated fatty acids in transgenic Camelina sativa

Authors: Lihua Han, Susana Silvestre, Olga Sayanova, Richard P Haslam, Johnathan A Napier

Journal: Plant Biotechnol J

PubMed ID: 35656640

Doi: 10.1111/pbi.13867

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Visualizing molecules of functional profilin

Authors: Morgan L Pimm, Xinbei Liu, Farzana Tuli, Jennifer Heritz, Ashley Lojko, Jessica L Henty-Ridilla

Journal: Elife

PubMed ID: 35666129

Doi: 10.7554/eLife.76485

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Synergistic interaction of Cry1Ah and Vip3Aa19 proteins combination with midgut ATP-binding cassette subfamily C receptors of Conogethes punctiferalis (Guenée) (Lepidoptera: Crambidae)

Authors: Su Mon Shwe, Sivaprasath Prabu, Dapeng Jing, Kanglai He, Zhenying Wang

Journal: Int J Biol Macromol

PubMed ID: 35690160

Doi: 10.1016/j.ijbiomac.2022.06.019

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Circular ribonucleic acid nucleoporin 98 knockdown alleviates high glucose-induced proliferation, fibrosis, inflammation and oxidative stress in human glomerular mesangial cells by regulating the microribonucleic acid-151-3p-high mobility group AT-hook 2 axis

Authors: Qianlan Dong, Longhao Dong, Yanting Zhu, Xiaoming Wang, Zhenjiang Li, Linping Zhang

Journal: J Diabetes Investig

PubMed ID: 35482475

Doi: 10.1111/jdi.13821

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Tomato brown rugose fruit virus resistance generated by quadruple knockout of homologs of TOBAMOVIRUS MULTIPLICATION1 in tomato

Authors: Masayuki Ishikawa, Tetsuya Yoshida, Momoko Matsuyama, Yusuke Kouzai, Akihito Kano, Kazuhiro Ishibashi

Journal: Plant Physiol

PubMed ID: 35262730

Doi: 10.1093/plphys/kiac103

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Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y

Authors: Yichao Zhu, Wenzhao Zhou, Zubiao Niu, Jiayi Sun, Zhengrong Zhang, Qinqin Li, You Zheng, Chenxi Wang, Lihua Gao, Qiang Sun

Journal: Biol Direct

PubMed ID: 35658928

Doi: 10.1186/s13062-022-00325-x

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Identification of Reference Genes for Reverse Transcription-Quantitative PCR Analysis of Ginger Under Abiotic Stress and for Postharvest Biology Studies

Authors: Gang Li, Jiawei Ma, Junliang Yin, Fengling Guo, Keyong Xi, Peihua Yang, Xiaodong Cai, Qie Jia, Lu Li, Yiqing Liu, Yongxing Zhu

Journal: Front Plant Sci

PubMed ID: 35734245

Doi: 10.3389/fpls.2022.893495

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A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse sera

Authors: Chotiwat Seephetdee, Kanit Bhukhai, Nattawut Buasri, Puttipatch Leelukkanaveera, Pat Lerdwattanasombat, Suwimon Manopwisedjaroen, Nut Phueakphud, Sakonwan Kuhaudomlarp, Eduardo Olmedillas, Erica Ollmann Saphire, Arunee Thitithanyanont, Suradej Hongeng, Patompon Wongtrakoongate

Journal: Antiviral Res

PubMed ID: 35772601

Doi: 10.1016/j.antiviral.2022.105370

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Peptidoglycan maturation controls outer membrane protein assembly

Authors: Gideon Mamou, Federico Corona, Ruth Cohen-Khait, Nicholas G Housden, Vivian Yeung, Dawei Sun, Pooja Sridhar, Manuel Pazos, Timothy J Knowles, Colin Kleanthous, Waldemar Vollmer

Journal: Nature

PubMed ID: 35705811

Doi: 10.1038/s41586-022-04834-7

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Overproduction, Purification, and Stability of the Functionally Active Human Carnitine Acetyl Transferase

Authors: Deborah Giudice, Lara Console, Arduino Arduini, Cesare Indiveri

Journal: Mol Biotechnol

PubMed ID: 35727434

Doi: 10.1007/s12033-022-00522-z

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Genomic insights into the recent chromosome reduction of autopolyploid sugarcane Saccharum spontaneum

Authors: Qing Zhang, Yiying Qi, Haoran Pan, Haibao Tang, Gang Wang, Xiuting Hua, Yongjun Wang, Lianyu Lin, Zhen Li, Yihan Li, Fan Yu, Zehuai Yu, Yongji Huang, Tianyou Wang, Panpan Ma, Meijie Dou, Zongyi Sun, Yibin Wang, Hengbo Wang, Xingtan Zhang, Wei Yao, Yuntong Wang, Xinlong Liu, Maojun Wang, Jianping Wang, Zuhu Deng, Jingsheng Xu, Qinghui Yang, ZhongJian Liu, Baoshan Chen, Muqing Zhang, Ray Ming, Jisen Zhang

Journal: Nat Genet

PubMed ID: 35654976

Doi: 10.1038/s41588-022-01084-1

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Coupled fibromodulin and SOX2 signaling as a critical regulator of metastatic outgrowth in melanoma

Authors: Victor O Oria, Hongyi Zhang, Christopher R Zito, Chetan K Rane, Xian-Yong Ma, Olivia K Provance, Thuy T Tran, Adebowale Adeniran, Yuval Kluger, Mario Sznol, Marcus W Bosenberg, Harriet M Kluger, Lucia B Jilaveanu

Journal: Cell Mol Life Sci

PubMed ID: 35737114

Doi: 10.1007/s00018-022-04364-5

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SpyChIP identifies cell type-specific transcription factor occupancy from complex tissues

Authors: Siqian Feng, Richard S Mann

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35696584

Doi: 10.1073/pnas.2122900119

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Regression of EGFR positive established solid tumors in mice with the conditionally active T cell engager TAK-186

Authors: Danielle E Dettling, Eilene Kwok, Lucy Quach, Aakash Datt, Jeremiah D Degenhardt, Anand Panchal, Pui Seto, Jessica L Krakow, Russell Wall, Brian J Hillier, Ying Zhu, Maia Vinogradova, Robert B DuBridge, Chad May

Journal: J Immunother Cancer

PubMed ID: 35728872

Doi: 10.1136/jitc-2021-004336

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Molecular insights into intra-complex signal transmission during stressosome activation

Authors: Algirdas Miksys, Lifei Fu, M Gregor Madej, Duarte N Guerreiro, Susann Kaltwasser, Maria Conway, Sema Ejder, Astrid Bruckmann, Jon Marles-Wright, Richard J Lewis, Conor O'Byrne, Jan Pané-Farré, Christine Ziegler

Journal: Commun Biol

PubMed ID: 35760945

Doi: 10.1038/s42003-022-03549-9

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GLYCINE-RICH RNA-BINDING PROTEIN 7 potentiates effector-triggered immunity through an RNA recognition motif

Authors: Octavina C A Sukarta, Qi Zheng, Erik J Slootweg, Mark Mekken, Melanie Mendel, Vera Putker, André Bertran, Anouk Brand, Hein Overmars, Rikus Pomp, Jan Roosien, Sjef Boeren, Geert Smant, Aska Goverse

Journal: Plant Physiol

PubMed ID: 35218353

Doi: 10.1093/plphys/kiac081

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Heterologous Expression and Characterization of Plant Wax Ester Producing Enzymes

Authors: Daolin Cheng, Ling Li, Ludmila Rizhsky, Priyanka Bhandary, Basil J Nikolau

Journal: Metabolites

PubMed ID: 35888701

Doi: 10.3390/metabo12070577

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Quercetin ameliorates salivary gland apoptosis and inflammation in primary Sjögren's syndrome through regulation of the leptin/OB-R signaling

Authors: Lihua Chang, Aibin Kong, Yun Guo, Jing Zhang, Yue Sun, Penglu Chen, Xiaofei Wang

Journal: Drug Dev Res

PubMed ID: 35749642

Doi: 10.1002/ddr.21964

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Potential of Aspergillus oryzae as a biosynthetic platform for indigoidine, a non-ribosomal peptide pigment with antioxidant activity

Authors: Sarocha Panchanawaporn, Chanikul Chutrakul, Sukanya Jeennor, Jutamas Anantayanon, Nakul Rattanaphan, Kobkul Laoteng

Journal: PLoS ONE

PubMed ID: 35737654

Doi: 10.1371/journal.pone.0270359

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Microstructured Hydrogels to Guide Self-Assembly and Function of Lung Alveolospheres

Authors: Claudia Loebel, Aaron I Weiner, Madeline K Eiken, Jeremy B Katzen, Michael P Morley, Vikram Bala, Fabian L Cardenas-Diaz, Matthew D Davidson, Kazushige Shiraishi, Maria C Basil, Laura T Ferguson, Jason R Spence, Matthias Ochs, Michael F Beers, Edward E Morrisey, Andrew E Vaughan, Jason A Burdick

Journal: Adv Mater

PubMed ID: 35522531

Doi: 10.1002/adma.202202992

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Lineage-specific insertions in T-box riboswitches modulate antibiotic binding and action

Authors: Nikoleta Giarimoglou, Adamantia Kouvela, Ioanna Patsi, Jinwei Zhang, Vassiliki Stamatopoulou, Constantinos Stathopoulos

Journal: Nucleic Acids Res

PubMed ID: 35580054

Doi: 10.1093/nar/gkac359

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Catalytic Properties of Caseinolytic Protease Subunit of and Its Inhibition by a Member of δ-Lactone, Hyptolide

Authors: Cahyo Budiman, Raimalynah Abd Razak, Angelesa Runin Anak Unggit, Rafida Razali, Meiny Suzery, Ruzaidi Azli Mohd Mokhtar, Ping-Chin Lee, Didik Huswo Utomo

Journal: Molecules

PubMed ID: 35744912

Doi: 10.3390/molecules27123787

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The Specificity of ParR Binding Determines the Incompatibility of Conjugative Plasmids in Clostridium perfringens

Authors: Thomas D Watts, Daouda A K Traore, Sarah C Atkinson, Carmen Lao, Natalie Caltabiano, Julian I Rood, Vicki Adams

Journal: MBio

PubMed ID: 35726914

Doi: 10.1128/mbio.01356-22

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