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The Integration of Proteome-Wide PTM Data with Protein Structural and Sequence Features Identifies Phosphorylations that Mediate 14-3-3 Interactions

Authors: C M Egbert, L R Warr, K L Pennington, M M Thornton, A J Vaughan, S W Ashworth, M J Heaton, N English, M P Torres, J L Andersen

Journal: J Mol Biol

PubMed ID: 36402225

Doi: 10.1016/j.jmb.2022.167890

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Human histone pre-mRNA assembles histone or canonical mRNA-processing complexes by overlapping 3'-end sequence elements

Authors: Francesco S Ielasi, Sara Ternifi, Emeline Fontaine, Domenico Iuso, Yohann Couté, Andrés Palencia

Journal: Nucleic Acids Res

PubMed ID: 36447390

Doi: 10.1093/nar/gkac878

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Chitosan-functionalized graphene oxide as adjuvant in HEV P239 vaccine

Authors: Qianyu Bai, Zhiwen Wang, Yina An, Jijing Tian, Zhilin Li, Yifei Yang, Yanjun Dong, Mingyong Chen, Tianlong Liu

Journal: Vaccine

PubMed ID: 36371365

Doi: 10.1016/j.vaccine.2022.11.005

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Biochemical Identification of a Nuclear Coactivator Protein Required for AtrR-Dependent Gene Regulation in Aspergillus fumigatus

Authors: Sanjoy Paul, Shivani Ror, W Hayes McDonald, W Scott Moye-Rowley

Journal: mSphere

PubMed ID: 36374043

Doi: 10.1128/msphere.00476-22

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KCNQ1OT1 sponges miR-34a to promote malignant progression of malignant melanoma via upregulation of the STAT3/PD-L1 axis

Authors: Xin Wang, Zhiyao Ren, Yunfeng Xu, Xiang Gao, Hainian Huang, Fei Zhu

Journal: Environ Toxicol

PubMed ID: 36399467

Doi: 10.1002/tox.23687

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PNGase H + variant from Rudaea cellulosilytica with improved deglycosylation efficiency for rapid analysis of eukaryotic N-glycans and hydrogen deuterium exchange mass spectrometry analysis of glycoproteins

Authors: Rui-Rui Guo, Tian-Chan Zhang, Thomas Ole Tandrup Lambert, Ting Wang, Josef Voglmeir, Kasper D Rand, Li Liu

Journal: Rapid Commun Mass Spectrom

PubMed ID: 35945033

Doi: 10.1002/rcm.9376

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Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses

Authors: Ruyu Wang, Guanglei Zhai, Guanghao Zhu, Mengge Wang, Xiaoyi Gong, Weidong Zhang, Guangbo Ge, Hongzhuan Chen, Lili Chen

Journal: Bioorg Chem

PubMed ID: 36395603

Doi: 10.1016/j.bioorg.2022.106264

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speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing

Authors: Rocío Castellanos-Rueda, Raphaël B Di Roberto, Florian Bieberich, Fabrice S Schlatter, Darya Palianina, Oanh T P Nguyen, Edo Kapetanovic, Heinz Läubli, Andreas Hierlemann, Nina Khanna, Sai T Reddy

Journal: Nat Commun

PubMed ID: 36323661

Doi: 10.1038/s41467-022-34141-8

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Mammalian Target of Rapamycin Inhibition Decreases Angiotensin II-Induced Steroidogenesis in HAC15 Human Adrenocortical Carcinoma Cells

Authors: Yusuf Ali, Elise P Gomez-Sanchez, Celso E Gomez-Sanchez

Journal: Endocrinology

PubMed ID: 36320101

Doi: 10.1210/endocr/bqac185

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Linoleic acid binds to SARS-CoV-2 RdRp and represses replication of seasonal human coronavirus OC43

Authors: Anna Goc, Waldemar Sumera, Matthias Rath, Aleksandra Niedzwiecki

Journal: Sci Rep

PubMed ID: 36352079

Doi: 10.1038/s41598-022-23880-9

Products & Services: DNA Sequencing

New Effective Method of Lactococcus Genome Editing Using Guide RNA-Directed Transposition

Authors: Pavel Yu Pechenov, Danil A Garagulya, Daniil S Stanovov, Andrey V Letarov

Journal: Int J Mol Sci

PubMed ID: 36430465

Doi: 10.3390/ijms232213978

Products & Services: Gene Fragments

Broad-specificity indirect competitive enzyme-linked immunosorbent assay for aristolochic acids: Computer-aided hapten design and molecular mechanism of antibody recognition

Authors: Xiaonan Wang, Qingpeng Lu, Leina Dou, Minggang Liu, Peipei Li, Wenbo Yu, Xuezhi Yu, Zhanhui Wang, Kai Wen

Journal: Sci Total Environ

PubMed ID: 36347294

Doi: 10.1016/j.scitotenv.2022.159941

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The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice

Authors: Karianne Fjeld, Anny Gravdal, Ranveig S Brekke, Jahedul Alam, Steven J Wilhelm, Khadija El Jellas, Helene N Pettersen, Jianguo Lin, Marie H Solheim, Solrun J Steine, Bente B Johansson, Pål R Njølstad, Caroline S Verbeke, Xunjun Xiao, Mark E Lowe, Anders Molven

Journal: Pancreatology

PubMed ID: 36379850

Doi: 10.1016/j.pan.2022.11.003

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Alginate-Chitosan Hydrogel Formulations Sustain Baculovirus Delivery and VEGFA Expression Which Promotes Angiogenesis for Wound Dressing Applications

Authors: Sabrina Schaly, Paromita Islam, Ahmed Abosalha, Jacqueline L Boyajian, Dominique Shum-Tim, Satya Prakash

Journal: Pharmaceuticals (Basel)

PubMed ID: 36355553

Doi: 10.3390/ph15111382

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Alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models

Authors: Thomas Caracena, Rachel Blomberg, Rukshika S Hewawasam, Zoe E Fry, David W H Riches, Chelsea M Magin

Journal: Biomater Sci

PubMed ID: 36366982

Doi: 10.1039/d2bm00827k

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Recent progress in adaptive laboratory evolution of industrial microorganisms

Authors: Guanglu Wang, Qian Li, Zhan Zhang, Xianzhong Yin, Bingyang Wang, Xuepeng Yang

Journal: J Ind Microbiol Biotechnol

PubMed ID: 36323428

Doi: 10.1093/jimb/kuac023

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A KLHL40 3' UTR splice-altering variant causes milder NEM8, an under-appreciated disease mechanism

Authors: Lein N H Dofash, Gavin V Monahan, Emilia Servián-Morilla, Eloy Rivas, Fathimath Faiz, Patricia Sullivan, Emily Oates, Joshua Clayton, Rhonda L Taylor, Mark R Davis, Traude Beilharz, Nigel G Laing, Macarena Cabrera-Serrano, Gianina Ravenscroft

Journal: Hum Mol Genet

PubMed ID: 36322148

Doi: 10.1093/hmg/ddac272

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Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signaling

Authors: Dennis Dik-Long Chau, Wen Li, Wai Wa Ray Chan, Jacquelyne Ka-Li Sun, Yuqi Zhai, Hei-Man Chow, Kwok-Fai Lau

Journal: FASEB J

PubMed ID: 36250347

Doi: 10.1096/fj.202200757R

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Retinal regions shape human and murine Müller cell proteome profile and functionality

Authors: Lew Kaplan, Corinne Drexler, Anna M Pfaller, Santra Brenna, Kirsten A Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M Hauck, Antje Grosche

Journal: Glia

PubMed ID: 36334068

Doi: 10.1002/glia.24283

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Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway

Authors: Yuyuan Yao, Zhichu Ren, Ruihan Yang, Yilan Mei, Yuying Dai, Qian Cheng, Chong Xu, Xiaogang Xu, Sanying Wang, Kyoung Mi Kim, Ji Heon Noh, Jian Zhu, Ningwei Zhao, Yong U Liu, Genxiang Mao, Jian Sima

Journal: Cell Biosci

PubMed ID: 36333711

Doi: 10.1186/s13578-022-00918-z

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Grafting of short elastin-like peptides using an electric field

Authors: Nuttanit Pramounmat, Sogol Asaei, Jacob D Hostert, Kathleen Young, Horst A von Recum, Julie N Renner

Journal: Sci Rep

PubMed ID: 36333395

Doi: 10.1038/s41598-022-21672-9

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Comprehensive profiling of the human viral exposome in households containing an at-risk child with mitochondrial disease during the 2020-2021 COVID-19 pandemic

Authors: Eliza M Gordon-Lipkin, Christopher S Marcum, Shannon Kruk, Elizabeth Thompson, Sophie E M Kelly, Heather Kalish, Lorenza Bellusci, Surender Khurana, Kaitlyn Sadtler, Peter J McGuire

Journal: Clin Transl Med

PubMed ID: 36336785

Doi: 10.1002/ctm2.1100

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Trifluoro-icaritin ameliorates spared nerve injury-induced neuropathic pain by inhibiting microglial activation through α7nAChR-mediated blockade of BDNF/TrkB/KCC2 signaling in the spinal cord of rats

Authors: Dandan Jia, Guangsen Liu, Yalan Sun, Zhiping Hu, Zhihua Huang, Cheng Huang

Journal: Biomed Pharmacother

PubMed ID: 36375307

Doi: 10.1016/j.biopha.2022.114001

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How modular protein nanoparticles may expand the ability of subunit anti-viral vaccines: The spring viremia carp virus (SVCV) case

Authors: Mauricio Rojas, Patricia Aceituno, Maria E Salvador, Marlid Garcia-Ordoñez, Mariana Teles, Maria Del Mar Ortega-Villaizan, Luis Perez, Nerea Roher

Journal: Fish Shellfish Immunol

PubMed ID: 36371050

Doi: 10.1016/j.fsi.2022.10.067

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SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1

Authors: Di Wang, Weiwei Liang, Di Huo, Hongyong Wang, Ying Wang, Chaohua Cong, Chunting Zhang, Shi Yan, Ming Gao, Xiaoli Su, Xingli Tan, Wenmo Zhang, Ling Han, Dongmei Zhang, Honglin Feng

Journal: Cell Death Differ

PubMed ID: 36443440

Doi: 10.1038/s41418-022-01089-7

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Immune responses of hemocytes in the blood clam Tegillarca granosa in response to in vivo Vibrio harveyi infection

Authors: Qianyuan Yang, Guoqiang Xiao, Ran Chen, Xiaolin Huang, Shuangshuang Teng

Journal: Fish Shellfish Immunol

PubMed ID: 36435369

Doi: 10.1016/j.fsi.2022.11.035

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Seroepidemiological and genomic investigation of SARS-CoV-2 spread in North East region of India

Authors: Romi Wahengbam, Pankaj Bharali, Prasenjit Manna, Tridip Phukan, Moirangthem Goutam Singh, Gayatri Gogoi, Yasmin Begam Tapadar, Anil Kumar Singh, Rituraj Konwar, Channakeshavaiah Chikkaputtaiah, Natarajan Velmurugan, Selvaraman Nagamani, Hridoy Jyoti Mahanta, Himakshi Sarma, Ravi Kumar Sahu, Prachurjya Dutta, Sawlang Borsingh Wann, Jatin Kalita, G Narahari Sastry

Journal: Indian J Med Microbiol

PubMed ID: 36371334

Doi: 10.1016/j.ijmmb.2022.10.011

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PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1

Authors: Yuzhong Chen, Wanqing Liang, Jun Du, Jiachi Ma, Rongrui Liang, Min Tao

Journal: Exp Cell Res

PubMed ID: 36400182

Doi: 10.1016/j.yexcr.2022.113413

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A basal actinopterygian melanocortin receptor: molecular and functional characterization of an Mc2r ortholog from the Senegal bichir (Polypterus senegalus).

Authors: Ciaran A Shaughnessy , Mary F Jensen , Robert M Dores

Journal: Gen Comp Endocrinol

PubMed ID: 35973587

Doi: 10.1016/j.ygcen.2022.114105

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A genetic approach to identify amino acids in Gcn1 required for Gcn2 activation

Authors: Susanne Gottfried , Siaosi M B M J Koloamatangi , Clement Daube , Anja H Schiemann , Evelyn Sattlegger

Journal: PLoS ONE

PubMed ID: 36441697

Doi: doi.org/10.1371/journal.pone.0277648

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Lipid metabolism reprogramming in colorectal cancer

Authors: Dan Chen, Xuebing Zhou, PengYu Yan, Chunyu Yang, Yuan Li, Longzhe Han, Xiangshan Ren

Journal: J Cell Biochem

PubMed ID: 36334309

Doi: 10.1002/jcb.30347

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Correction: Identification of novel HLA-A*11:01-restricted HPV16 E6/E7 epitopes and T-cell receptors for HPV-related cancer immunotherapy

Authors:

Journal: J Immunother Cancer

PubMed ID: 36332929

Doi: 10.1136/jitc-2022-004790corr1

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Autoimmune haemolytic anaemia

Authors: María Argüello Marina, Montserrat López Rubio, Lucía Castilla García

Journal: Med Clin (Barc)

PubMed ID: 36334945

Doi: 10.1016/j.medcli.2022.07.021

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A Δ42PD1 fusion-expressing DNA vaccine elicits enhanced adaptive immune response to HIV-1: the key role of TLR4

Authors: Lin Cheng, Xian Tang, Yun He, Bin Ju, Hui Wang

Journal: Virol J

PubMed ID: 36320043

Doi: 10.1186/s12985-022-01909-9

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Allosteric potentiation of GABA receptor single-channel conductance by netrin-1 during neuronal-excitation-induced inhibitory synaptic homeostasis

Authors: Elizabeth S Chan, Yang Ge, Yee Wah So, Yun-Fei Bai, Lidong Liu, Yu Tian Wang

Journal: Cell Rep

PubMed ID: 36323250

Doi: 10.1016/j.celrep.2022.111584

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Phosphate limitation intensifies negative effects of ocean acidification on globally important nitrogen fixing cyanobacterium

Authors: Futing Zhang, Zuozhu Wen, Shanlin Wang, Weiyi Tang, Ya-Wei Luo, Sven A Kranz, Haizheng Hong, Dalin Shi

Journal: Nat Commun

PubMed ID: 36344528

Doi: 10.1038/s41467-022-34586-x

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Analysis of the HbpA Protein from Corynebacterium diphtheriae Clinical Isolates and Identification of a Putative Hemoglobin-Binding Site on HbpA

Authors: Lindsey R Lyman, Justine Schaeffer, Werner Ruppitsch, Michael P Schmitt

Journal: J Bacteriol

PubMed ID: 36346227

Doi: 10.1128/jb.00349-22

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TARDBP promotes ovarian cancer progression by altering vascular endothelial growth factor splicing

Authors: Yutian He, Zhenbo OuYang, Wenwen Liu, Yu Chen, Qiushi Zhang

Journal: Oncogene

PubMed ID: 36369320

Doi: 10.1038/s41388-022-02539-9

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Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties

Authors: Hannah N Corman, Jessica N Ross, Francisco R Fields, Douglas A Shoue, Shaun W Lee, Mary Ann McDowell

Journal: Microbiol Spectr

PubMed ID: 36342284

Doi: 10.1128/spectrum.02658-22

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TMBIM5 is the Ca /H antiporter of mammalian mitochondria

Authors: Shane Austin, Ronald Mekis, Sami E M Mohammed, Mariafrancesca Scalise, Wen-An Wang, Michele Galluccio, Christina Pfeiffer, Tamara Borovec, Katja Parapatics, Dijana Vitko, Nora Dinhopl, Nicolas Demaurex, Keiryn L Bennett, Cesare Indiveri, Karin Nowikovsky

Journal: EMBO Rep

PubMed ID: 36321428

Doi: 10.15252/embr.202254978

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In silico analysis of a novel protein in CAR T- cell therapy for the treatment of hematologic cancer through molecular modelling, docking, and dynamics approach

Authors: Rimjhim Mohanty, Manoswini Manoswini, Ajit Kumar Dhal, Niladri Ganguly

Journal: Comput Biol Med

PubMed ID: 36395593

Doi: 10.1016/j.compbiomed.2022.106285

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synDNA-a Synthetic DNA Spike-in Method for Absolute Quantification of Shotgun Metagenomic Sequencing

Authors: Livia S Zaramela, Megan Tjuanta, Oriane Moyne, Maxwell Neal, Karsten Zengler

Journal: mSystems

PubMed ID: 36317886

Doi: 10.1128/msystems.00447-22

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Transport of symbiont-encoded cellulases from the gill to the gut of shipworms via the enigmatic ducts of Deshayes: a 174-year mystery solved

Authors: Marvin A Altamia, Daniel L Distel

Journal: Proc Biol Sci

PubMed ID: 36350208

Doi: 10.1098/rspb.2022.1478

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Heat shock protein 20 suppresses breast carcinogenesis by inhibiting the MAPK and AKT signaling pathways

Authors: Yinxi Yang, Yifeng Wu, Lihong Hou, Xin Ge, Guoquan Song, Hongdou Jin

Journal: Oncol Lett

PubMed ID: 36380873

Doi: 10.3892/ol.2022.13582

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Prevalence of Neospora caninum, Toxoplasma gondii and Brucella abortus in water buffalo (Bubalus bubalis): Climatic and environmental risk factors in eastern and southeast Mexico

Authors: J Baltazar-Pérez, F Utrera-Quintana, J Camacho-Ronquillo, R González-Garduño, H Jiménez-Cortez, A Villa-Mancera

Journal: Microb Pathog

PubMed ID: 36356791

Doi: 10.1016/j.micpath.2022.105871

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Genome-wide identification of FAR gene family and functional analysis of NlFAR10 during embryogenesis in the brown planthopper Nilaparvata lugens

Authors: Xiaobin Fan, Wenqing Zhang

Journal: Int J Biol Macromol

PubMed ID: 36375673

Doi: 10.1016/j.ijbiomac.2022.11.075

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Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types

Authors: Madhuvanthi Kannan, Ganesh Vasan, Simon Haziza, Cheng Huang, Radosław Chrapkiewicz, Junjie Luo, Jessica A Cardin, Mark J Schnitzer, Vincent A Pieribone

Journal: Science

PubMed ID: 36378956

Doi: 10.1126/science.abm8797

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The role of carbonic anhydrase-mediated tissue oxygen extraction in a marine teleost acclimated to hypoxia

Authors: Angelina M Dichiera, Benjamin Negrete, Kerri Lynn Ackerly, Andrew J Esbaugh

Journal: J Exp Biol

PubMed ID: 36354111

Doi: 10.1242/jeb.244474

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Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections

Authors: Catherine B Blackwood, Margalida Mateu-Borrás, Emel Sen-Kilic, Gage M Pyles, Sarah Jo Miller, Kelly L Weaver, William T Witt, Annalisa B Huckaby, Jason Kang, Courtney E Chandler, Robert K Ernst, F Heath Damron, Mariette Barbier

Journal: npj Vaccines

PubMed ID: 36357402

Doi: 10.1038/s41541-022-00562-1

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Identification of African swine fever virus MGF505-2R as a potent inhibitor of innate immunity in vitro

Authors: Huaguo Huang, Wen Dang, Zhengwang Shi, Mingyang Ding, Fan Xu, Tao Li, Tao Feng, Haixue Zheng, Shuqi Xiao

Journal: Virol Sin

PubMed ID: 36442611

Doi: 10.1016/j.virs.2022.11.009

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Pathogenic Interleukin-10 Receptor Alpha Variants in Humans - Balancing Natural Selection and Clinical Implications

Authors: Dominik Aschenbrenner, Ziqing Ye, Ying Zhou, Wenhui Hu, Isabel Brooks, Isabelle Williams, Melania Capitani, Lisa Gartner, Daniel Kotlarz, Scott B Snapper, Christoph Klein, Aleixo M Muise, Brian D Marsden, Ying Huang, Holm H Uhlig

Journal: J Clin Immunol

PubMed ID: 36370291

Doi: 10.1007/s10875-022-01366-7

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Quantum Dot-Based Molecular Beacons for Quantitative Detection of Nucleic Acids with CRISPR/Cas(N) Nucleases

Authors: Christopher M Green, Joseph Spangler, Kimihiro Susumu, David A Stenger, Igor L Medintz, Sebastián A Díaz

Journal: ACS Nano

PubMed ID: 36378103

Doi: 10.1021/acsnano.2c07749

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Antibody and T Cell Immune Responses to SARS-CoV-2 Peptides in COVID-19 Convalescent Patients

Authors: Kristina V Kitaeva , Daria S Chulpanova , Margarita N Zhuravleva , Ivan Yu Filin , Ruslan M Deviatiiarov , Alyssa C Ballard-Reisch , Albert A Rizvanov , Valeriya V Solovyeva

Journal: Bioengineering (Basel) .

PubMed ID: 36354566

Doi: 10.3389/fmicb.2022.842232

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Characteristics and Resistance to Cisplatin of Human Neuroblastoma Cells Co-Cultivated with Immune and Stromal Cells

Authors: Kristina V Kitaeva , Daria S Chulpanova , Margarita N Zhuravleva , Ivan Yu Filin , Ruslan M Deviatiiarov , Alyssa C Ballard-Reisch , Albert A Rizvanov , Valeriya V Solovyeva

Journal: Bioengineering (Basel) .

PubMed ID: 36354566

Doi: 10.3390/bioengineering9110655

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A reversible cell penetrating peptide-cargo linkage allows dissection of cell penetrating peptide- and cargo-dependent effects on internalization and identifies new functionalities of putative endolytic peptides

Authors: Daniel P Morris, Lucy C Snipes, Stephanie A Hill, Michael M Woods, Maria M Mbugua, Lydia R Wade, Jonathan L McMurry

Journal: Front Pharmacol .

PubMed ID: 36479201

Doi: 10.3389/fphar.2022.1070464

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An engineered (CAGA)-EGFP cell-based biosensor for high-content and accurate detection of active TGF-β

Authors: Qian Ruan, Xuezhen Lin, Lixia Wang, Niu Wang, Yu Zhao, Hao Wang, Fu-Ying Tian, Ning Hu, Ying Li, Bo Zhao

Journal: Biosens Bioelectron

PubMed ID: 36403492

Doi: 10.1016/j.bios.2022.114884

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Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism

Authors: Jie Shen, Qian Zha, Qian-Hua Yang, Yue-Qian Zhou, Xiao Liang, Ying-Jie Chen, Gui-Xia Qi, Xiao-Jin Zhang, Wen-Bing Yao, Xiang-Dong Gao, Song Chen

Journal: Acta Pharmacol Sin

PubMed ID: 36357669

Doi: 10.1038/s41401-022-01014-1

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Fitness Costs of pfhrp2 and pfhrp3 Deletions Underlying Diagnostic Evasion in Malaria Parasites

Authors: Shalini Nair, Xue Li, Standwell C Nkhoma, Tim Anderson

Journal: J Infect Dis

PubMed ID: 35709327

Doi: 10.1093/infdis/jiac240

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Sequestration of a dual function DNA-binding protein by Vibrio cholerae CRP

Authors: Jacob A Gibson, Michael J Gebhardt, Renato E R S Santos, Simon L Dove, Paula I Watnick

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36343262

Doi: 10.1073/pnas.2210115119

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A glutamine-based single α-helix scaffold to target globular proteins

Authors: Albert Escobedo, Jonathan Piccirillo, Juan Aranda, Tammo Diercks, Borja Mateos, Carla Garcia-Cabau, Macarena Sánchez-Navarro, Busra Topal, Mateusz Biesaga, Lasse Staby, Birthe B Kragelund, Jesús García, Oscar Millet, Modesto Orozco, Murray Coles, Ramon Crehuet, Xavier Salvatella

Journal: Nat Commun

PubMed ID: 36400768

Doi: 10.1038/s41467-022-34793-6

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Bovine milk exosomes affected proliferation of macrophages under hypoxia

Authors: Svjetlana Matic, Vermont P Dia

Journal: Curr Res Food Sci

PubMed ID: 36387601

Doi: 10.1016/j.crfs.2022.11.002

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Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Authors: Liang Chen, Biyun Zhu, Gaomeng Ru, Haowei Meng, Yongchang Yan, Mengjia Hong, Dan Zhang, Changming Luan, Shun Zhang, Hao Wu, Hongyi Gao, Sijia Bai, Changqing Li, Ruoyi Ding, Niannian Xue, Zhixin Lei, Yuting Chen, Yuting Guan, Stefan Siwko, Yiyun Cheng, Gaojie Song, Liren Wang, Chengqi Yi, Mingyao Liu, Dali Li

Journal: Nat Biotechnol

PubMed ID: 36357717

Doi: 10.1038/s41587-022-01532-7

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Insights into glycosidic bond specificity of an engineered selective α-L-rhamnosidase N12-Rha via activity assays and molecular modelling

Authors: Bo Yu, Shiyu Luo, Yuhan Ding, Zijie Gong, Ting Nie

Journal: AMB Express

PubMed ID: 36370155

Doi: 10.1186/s13568-022-01489-5

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A Vaccine of SARS-CoV-2 S Protein RBD Induces Protective Immunity

Authors: Qiaoqiao Qu, Pengfei Hao, Wang Xu, Letian Li, Yuhang Jiang, Zhiqiang Xu, Jing Chen, Zihan Gao, Zhaoxia Pang, Ningyi Jin, Chang Li

Journal: Int J Mol Sci

PubMed ID: 36430190

Doi: 10.3390/ijms232213716

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The effect of mutations on binding interactions between the SARS-CoV-2 receptor binding domain and neutralizing antibodies B38 and CB6

Authors: Jonathan E Barnes, Peik K Lund-Andersen, Jagdish Suresh Patel, F Marty Ytreberg

Journal: Sci Rep

PubMed ID: 36335244

Doi: 10.1038/s41598-022-23482-5

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Design and optimization of enzymatic activity in a de novo β-barrel scaffold

Authors: Yakov Kipnis, Anissa Ouald Chaib, Anastassia A Vorobieva, Guangyang Cai, Gabriella Reggiano, Benjamin Basanta, Eshan Kumar, Peer R E Mittl, Donald Hilvert, David Baker

Journal: Protein Sci

PubMed ID: 36305767

Doi: 10.1002/pro.4405

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Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomes

Authors: Neil Berry, Deborah Ferguson, Sarah Kempster, Jo Hall, Claire Ham, Adrian Jenkins, Vicky Rannow, Elaine Giles, Rose Leahy, Sara Goulding, Arturo Fernandez, Yemisi Adedeji, Sandrine Vessillier, Deepa Rajagopal, Sandra Prior, Yann Le Duff, Matthew Hurley, Sarah Gilbert, Martin Fritzsche, Ryan Mate, Nicola Rose, Robert J Francis, Kirsty MacLellan-Gibson, Alejandro Suarez-Bonnet, Simon Priestnall, Neil Almond

Journal: Sci Rep

PubMed ID: 36333445

Doi: 10.1038/s41598-022-23339-x

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Identification of a novel ALDH1A3-selective inhibitor by a chemical probe with unrelated bioactivity: An approach to affinity-based drug target discovery

Authors: Hiroshi Kamiyama, Masayuki Miyano, Daisuke Ito, Takayuki Kimura, Koji Hagiwara, Hiroyuki Kogai, Yosuke Kaburagi, Yoshihiko Kotake, Yasutaka Takase

Journal: Chem Biol Drug Des

PubMed ID: 36334047

Doi: 10.1111/cbdd.14176

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Base-editing-mediated dissection of a γ-globin cis-regulatory element for the therapeutic reactivation of fetal hemoglobin expression

Authors: Panagiotis Antoniou, Giulia Hardouin, Pierre Martinucci, Giacomo Frati, Tristan Felix, Anne Chalumeau, Letizia Fontana, Jeanne Martin, Cecile Masson, Megane Brusson, Giulia Maule, Marion Rosello, Carine Giovannangeli, Vincent Abramowski, Jean-Pierre de Villartay, Jean-Paul Concordet, Filippo Del Bene, Wassim El Nemer, Mario Amendola, Marina Cavazzana, Anna Cereseto, Oriana Romano, Annarita Miccio

Journal: Nat Commun

PubMed ID: 36333351

Doi: 10.1038/s41467-022-34493-1

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Association of neutrophil extracellular traps with fistula healing in patients with complex perianal fistulising Crohn's disease

Authors: Dongxing Cao, Keyu Qian, Ying Zhao, Jie Hong, Haoyan Chen, Xiaohui Wang, Nailin Yang, Cheng Zhang, Jingkai Cao, Keyu Jia, Guangyu Wu, Mingming Zhu, Jun Shen, Ye Zhang, Zhe Cui, Zheng Wang

Journal: J Crohns Colitis

PubMed ID: 36322703

Doi: 10.1093/ecco-jcc/jjac171

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Ectopic circSTK39 expression ameliorates hydrogen peroxide-induced human lens epithelial cell apoptosis and oxidative stress through the miR-125a-5p/ERCC6 pathway

Authors: Ming Guo, Fanfan Su, Yao Chen, Bo Su

Journal: Curr Eye Res

PubMed ID: 36322706

Doi: 10.1080/02713683.2022.2143529

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Developmentally regulated mitochondrial biogenesis and cell death competence in maize pollen

Authors: Karen C Chamusco, May N Milazzo, Kanchan S Bhan, Terry L Kamps, Prestina Smith, Modupeoluwa Durojaiye, Cristina D Moreira, Maria Gallo, Christine D Chase

Journal: BMC Plant Biol

PubMed ID: 36316635

Doi: 10.1186/s12870-022-03897-y

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A microbial transporter of the dietary antioxidant ergothioneine

Authors: Daniel G Dumitrescu, Elizabeth M Gordon, Yekaterina Kovalyova, Anna B Seminara, Brianna Duncan-Lowey, Emily R Forster, Wen Zhou, Carmen J Booth, Aimee Shen, Philip J Kranzusch, Stavroula K Hatzios

Journal: Cell

PubMed ID: 36347253

Doi: 10.1016/j.cell.2022.10.008

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Proteomic Landscape and Deduced Functions of the Cardiac 14-3-3 Protein Interactome

Authors: Jia-Hua Qu, Kirill V Tarasov, Khalid Chakir, Yelena S Tarasova, Daniel R Riordon, Edward G Lakatta

Journal: Cells

PubMed ID: 36359893

Doi: 10.3390/cells11213496

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Evaluation of commercially available fully automated and ELISA-based assays for detecting anti-SARS-CoV-2 neutralizing antibodies

Authors: Hadeel T Zedan, Hadi M Yassine, Duaa W Al-Sadeq, Na Liu, Hamda Qotba, Eleonora Nicolai, Massimo Pieri, Sergio Bernardini, Laith J Abu-Raddad, Gheyath K Nasrallah

Journal: Sci Rep

PubMed ID: 36347859

Doi: 10.1038/s41598-022-21317-x

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Chaperoning activity of the cyclophilin family prevents tau aggregation

Authors: Shannon E Hill , Abigail R Esquivel , Santiago Rodriguez Ospina , Lauren M Rahal , Chad A Dickey , Laura J Blair

Journal: Protein Sci

PubMed ID: 36305768

Doi: 10.1002/pro.4448

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Structure/function studies on the activation motif of two non-mammalian Mrap1 orthologs, and observations on the phylogeny of Mrap1, including a novel characterization of an Mrap1 from the chondrostean fish, Polyodon spathula.

Authors: Robert M. Dores , Greer McKinley, Audrey Meyers, Morgan Martin and Ciaran A. Shaughnessy

Journal: Biomolecules

Doi: 10.3390/biom12111681

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Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes

Authors: Zeyu Jin , Li Wan , Yuqi Zhang , Xuecheng Li , Yong Cao , Haobin Liu , Shengyao Fan , Du Cao , Zhengmao Wang , Xiaobo Li , Junmin Pan , Meng-Qiu Dong , Jianping Wu , Zhen Yan

Journal: Cell

PubMed ID: 36413996

Doi: 10.1016/j.cell.2022.10.030

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Rice FLOURY ENDOSPERM22, encoding a pentatricopeptide repeat protein, is involved in both mitochondrial RNA splicing and editing and is crucial for endosperm development

Authors: Hang Yang , Yunlong Wang , Yunlu Tian , Xuan Teng , Zehui Lv , Jie Lei , Erchao Duan , Hui Dong , Xue Yang , Yuanyan Zhang , Yinglun Sun , Xiaoli Chen , Xiuhao Bao , Rongbo Chen , Chuanwei Gu , Yipeng Zhang , Xiaokang Jiang , Wenyu Ma , Pengcheng Zhang , Yi Ji , Yu Zhang , Yihua Wang , Jianmin Wan

Journal: J Integr Plant Biol

PubMed ID: 36333887

Doi: 10.1111/jipb.13402

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Sustained Activation of CLR/RAMP Receptors by Gel-Forming Agonists

Authors: Chia Lin Chang, Zheqing Cai, Sheau Yu Teddy Hsu

Journal: Int J Mol Sci

PubMed ID: 36362188

Doi: 10.3390/ijms232113408

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Structure-based engineering of minimal Proline dehydrogenase domains for inhibitor discovery

Authors: Alexandra N Bogner, Juan Ji, John J Tanner

Journal: Protein Eng Des Sel

PubMed ID: 36448708

Doi: 10.1093/protein/gzac016

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Detection of concentration-dependent conformational changes in SARS-CoV-2 nucleoprotein by agarose native gel electrophoresis

Authors: Ryo Sato, Yui Tomioka, Chiaki Sakuma, Masataka Nakagawa, Yasunori Kurosawa, Kohei Shiba, Tsutomu Arakawa, Teruo Akuta

Journal: Anal Biochem

PubMed ID: 36427555

Doi: 10.1016/j.ab.2022.114995

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Selection of Brucella abortus mimetic epitopes for fast diagnostic purposes in cattle

Authors: Fabiana de Almeida Araújo Santos, Patrícia Tiemi Fujimura, Emília Rezende Vaz, Ana Cristina Honorato de Castro, Ana Graci Brito-Madurro, Vivian Alonso-Goulart, Luciana Machado Bastos, Belchiolina Beatriz Fonseca, Anna Monteiro Correia Lima, Luiz Ricardo Goulart

Journal: Vet Res Commun

PubMed ID: 36445603

Doi: 10.1007/s11259-022-10043-4

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Estrogen receptor β activation inhibits colitis by promoting NLRP6-mediated autophagy

Authors: Wentao Fan, Chenchen Ding, Shuhui Liu, Xiaona Gao, Xiaofei Shen, Marthe De Boevre, Zhangshan Gao, Mengcong Li, Shuo Zhang, Yufan Miao, Wenxian Guan, Guangliang Liu, Liping Yan, Sarah De Saeger, Suquan Song

Journal: Cell Rep

PubMed ID: 36223738

Doi: 10.1016/j.celrep.2022.111454

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Duration of antiretroviral therapy impacts the degree of residual SIV infection in the gut in long-term non-progressing Chinese rhesus macaques

Authors: Antonio Solis-Leal, Ann-Marie May, Mahesh Mohan, Jason P Dufour, Binhua Ling

Journal: J Med Virol

PubMed ID: 36181356

Doi: 10.1002/jmv.28185

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Recombinant acetylxylan esterase of Halalkalibacterium halodurans NAH-Egypt: molecular and biochemical study.

Authors: Amira M Embaby , Hoda E Mahmoud

Journal: AMB Express .

PubMed ID: 36289146

Doi: A10.1186/s13568-022-01476-w.

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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PDL1 bias-dependent way

Authors: Xiaolu Yu, Yiru Long , Binfan Chen , Yongliang Tong , Mengwen Shan , Xiaomin Jia , Chao Hu , Meng Liu , Ji Zhou , Feng Tang , Henglei Lu , Runqiu Chen , Pan Xu , Wei Huang , Jin Ren , Yakun Wan , Jianhua Sun , Jia Li , Guangyi Jin , Likun Gong

Journal: J Immunother Cancer .

PubMed ID: 36253000

Doi: 10.1136/jitc-2022-004590

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Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease

Authors: Hangchen Hu, Qian Wang, Haixia Su, Qiang Shao, Wenfeng Zhao, Guofeng Chen, Minjun Li, Yechun Xu

Journal: Angew Chem Int Ed Engl

PubMed ID: 36308706

Doi: 10.1002/anie.202212378

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Molecular Effects of Iodine-Biofortified Lettuce in Human Gastrointestinal Cancer Cells

Authors: Olga Sularz, Aneta Koronowicz, Cayla Boycott, Sylwester Smoleń, Barbara Stefanska

Journal: Nutrients

PubMed ID: 36296971

Doi: 10.3390/nu14204287

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TMT-Based Quantitative Proteomic Analysis Reveals Downregulation of ITGAL and Syk by the Effects of Cycloastragenol in OVA-Induced Asthmatic Mice

Authors: Xueyi Zhu, Baojun Liu, Zhenhui Ruan, Mengmeng Chen, Congcong Li, Hanlin Shi, Xi Huang, Hang Yu, Yaolong Zhou, Hehua Zhu, Jing Sun, Ying Wei, Weifang Xu, Jingcheng Dong

Journal: Oxid Med Cell Longev

PubMed ID: 36329800

Doi: 10.1155/2022/6842530

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Photoprotective Effects of Cannabidiol against Ultraviolet-B-Induced DNA Damage and Autophagy in Human Keratinocyte Cells and Mouse Skin Tissue

Authors: Yanmei Li, Dan Hao, Danfeng Wei, Yue Xiao, Lian Liu, Xiaoxue Li, Lian Wang, Yu Gan, Wei Yan, Bowen Ke, Xian Jiang

Journal: Molecules

PubMed ID: 36235276

Doi: 10.3390/molecules27196740

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Molecular characterization of peptidoglycan recognition proteins from Mytilus coruscus

Authors: Zhi Liao, Zongxin Yang, Ying Wang, Jianyu He, Zhijiang He, Xiaolin Zhang, Isabella Buttino, Pengzhi Qi, Meihua Fan, Baoying Guo, Xiaojun Yan, Menglan He

Journal: Fish Shellfish Immunol

PubMed ID: 36272520

Doi: 10.1016/j.fsi.2022.10.018

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Regulation of Prolactin Release at the End Stage of Chicken Embryogenesis

Authors: Norio Kansaku, Shin Wakui, Tomohiro Sasanami, Takeshi Ohkubo

Journal: J Poult Sci

PubMed ID: 36382060

Doi: 10.2141/jpsa.0220023

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TBC1D18 is a Rab5-GAP that coordinates endosome maturation together with Mon1

Authors: Shu Hiragi, Takahide Matsui, Yuriko Sakamaki, Mitsunori Fukuda

Journal: J Cell Biol

PubMed ID: 36197338

Doi: 10.1083/jcb.202201114

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The diurnal emission of floral scent in Oncidium hybrid orchid is controlled by CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) through the direct regulation on terpene synthase

Authors: Chao-Wei Yeh, Hui-Qin Zhong, Yung-Feng Ho, Zhi-Hong Tian, Kai-Wun Yeh

Journal: BMC Plant Biol

PubMed ID: 36195835

Doi: 10.1186/s12870-022-03850-z

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Highly efficient hybridoma generation and screening strategy for anti-PD-1 monoclonal antibody development

Authors: Tanapati Phakham, Chatikorn Boonkrai, Tossapon Wongtangprasert, Thittaya Audomsun, Chadaporn Attakitbancha, Pijitra Saelao, Phijitra Muanwien, Sarintip Sooksai, Nattiya Hirankarn, Trairak Pisitkun

Journal: Sci Rep

PubMed ID: 36273231

Doi: 10.1038/s41598-022-20560-6

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Hydrogen-bonds mediate liquid-liquid phase separation of mussel derived adhesive peptides

Authors: Qi Guo, Guijin Zou, Xuliang Qian, Shujun Chen, Huajian Gao, Jing Yu

Journal: Nat Commun

PubMed ID: 36182948

Doi: 10.1038/s41467-022-33545-w

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An experimental test of the nicotinic hypothesis of COVID-19

Authors: Nicole E Godellas, Gisela D Cymes, Claudio Grosman

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36279466

Doi: 10.1073/pnas.2204242119

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Ultra-sensitive molecular detection of gene fusions from RNA using ASPYRE

Authors: Eleanor R Gray, Justyna M Mordaka, Efthimia R Christoforou, Kristine von Bargen, Nicola D Potts, Christina Xyrafaki, Ana-Luisa Silva, Magdalena Stolarek-Januszkiewicz, Katarzyna Anton, Paulina K Powalowska, Simonetta Andreazza, Alessandro Tomassini, Rebecca N Palmer, Aishling Cooke, Robert J Osborne, Barnaby W Balmforth

Journal: BMC Med Genomics

PubMed ID: 36224552

Doi: 10.1186/s12920-022-01363-0

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Long noncoding RNA-mediated activation of PROTOR1/PRR5-AKT signaling shunt downstream of PI3K in triple-negative breast cancer

Authors: Zhenbo Tu, Yi Hu, Devesh Raizada, Mahmoud A Bassal, Daniel G Tenen, Antoine E Karnoub

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36269860

Doi: 10.1073/pnas.2203180119

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