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Pro-Survival Factor EDEM3 Confers Therapy Resistance in Prostate Cancer

Authors: Emma Scott, Rebecca Garnham, Kathleen Cheung, Adam Duxfield, David J Elliott, Jennifer Munkley

Journal: Int J Mol Sci

PubMed ID: 35897761

Doi: 10.3390/ijms23158184

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An adaptable platform for in-house hepatitis C serology

Authors: Jannie Pedersen, Irène Pegha Moukandja, Stella Ndidi, Anna-Louise Sørensen, Ismaël Hervé Koumakpayi, Jean-Bernard Lekana-Douki, Marie-Louise Vachon, Nina Weis, Gary Kobinger, Hugues Fausther-Bovendo

Journal: J Virol Methods

PubMed ID: 35850366

Doi: 10.1016/j.jviromet.2022.114586

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Physical activity and antibody persistence 6 months after the second dose of CoronaVac in immunocompromised patients

Authors: Bruno Gualano, Ítalo Ribeiro Lemes, Rafael Pires da Silva, Ana Jéssica Pinto, Bruna Caruso Mazzolani, Fabiana Infante Smaira, Sofia Mendes Sieczkowska, Nádia Emi Aikawa, Sandra Pasoto, Ana Cristina Medeiros-Ribeiro, Carla Saad, Emily Yuk, Clovis Silva, Paul Swinton, Pedro Curi Hallal, Hamilton Roschel, Eloisa Bonfa

Journal: Scand J Med Sci Sports

PubMed ID: 35844042

Doi: 10.1111/sms.14213

High Mobility Group Protein B1 Decreases Surface Localization of PD-1 to Augment T-cell Activation

Authors: Qun Gao, Shumin Wang, Feng Li, Jingyao Lian, Shaoyan Cheng, Dongli Yue, Zhen Zhang, Shasha Liu, Feifei Ren, Daiqun Zhang, Shengdian Wang, Liping Wang, Yi Zhang

Journal: Cancer Immunol Res

PubMed ID: 35580259

Doi: 10.1158/2326-6066.CIR-21-0652

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Structures of the T cell potassium channel Kv13 with immunoglobulin modulators

Authors: Purushotham Selvakumar, Ana I Fernández-Mariño, Nandish Khanra, Changhao He, Alice J Paquette, Bing Wang, Ruiqi Huang, Vaughn V Smider, William J Rice, Kenton J Swartz, Joel R Meyerson

Journal: Nat Commun

PubMed ID: 35788586

Doi: 10.1038/s41467-022-31285-5

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Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition

Authors: Elena G Govorunova , Yueyang Gou , Oleg A Sineshchekov , Hai Li , Xiaoyu Lu , Yumei Wang , Leonid S Brown , François St-Pierre , Mingshan Xue , John L Spudich

Journal: Nature neuroscience

PubMed ID: 35726059

Doi: 10.1038/s41593-022-01094-6

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Core cysteine residues in the Plasminogen-Apple-Nematode (PAN) domain are critical for HGF/c-MET signaling

Authors: Debjani Pal , Kuntal De , Carly M Shanks , Kai Feng , Timothy B Yates , Jennifer Morrell-Falvey , Russell B Davidson , Jerry M Parks , Wellington Muchero

Journal: Commun Biol

PubMed ID: 35778602

Doi: 10.1038/s42003-022-03582-8

Products & Services: Proteins, Expression, Isolation and Analysis

Hsp70 inhibits the replication of Fowl Adenovirous serotype 4 by suppressing viral Hexon with the assistance of DnaJC7

Authors: Jie Cao , Shuhui Liu , Meng Liu , Shuaiwen Wang , Zhenwei Bi , Wentao Fan , Zhiyu Shi , Suquan Song , Liping Yan

Journal: J Virol

PubMed ID: 35852354

Doi: 10.1128/jvi.00807-22

Products & Services: Proteins, Expression, Isolation and Analysis

Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker

Authors: Aslan Mansurov , Peyman Hosseinchi, Kevin Chang, Abigail L Lauterbach, Laura T Gray , Aaron T Alpar , Erica Budina , Anna J Slezak , Seounghun Kang, Shijie Cao, Ani Solanki , Suzana Gomes , John-Michael Williford, Melody A Swartz , Juan L Mendoza , Jun Ishihara , Jeffrey A Hubbell

Journal: Nat Biomed Eng

PubMed ID: 35534574

Doi: 10.1038/s41551-022-00888-0

Products & Services: Mammalian Expression

Identification of nucleoside monophosphates and their epigenetic modifications using an engineered nanopore.

Authors: Yuqin Wang , Shanyu Zhang , Wendong Jia ,Pingping Fan , Liying Wang , Xinyue Li , Jialu Chen , Zhenyuan Cao , Xiaoyu Du , Yao Liu , Kefan Wang , Chengzhen Hu , Jinyue Zhang , Jun Hu , Panke Zhang , Hong-Yuan Chen , Shuo Huang

Journal: Nat Nanotechnol

PubMed ID: 35851382

Doi: 10.1038/s41565-022-01169-2

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Oncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancer

Authors: Qiuman Wang , Xinyue Ma , Huan Wu , Chen Zhao 1, Jingying Chen , Rongrong Li , Shi Yan , Yingwei Li , Qing Zhang , Kun Song , Cunzhong Yuan , Beihua Kong

Journal: Oncoimmunology

PubMed ID: 35800156

Doi: 10.1080/2162402X.2022.2096362 Free PMC article

Products & Services: Proteins, Expression, Isolation and Analysis

Developing and validating SARS-CoV-2 assays for nonhuman primate surveillance

Authors: JoAnn Yee, Amanda Carpenter, Peter Nham, Bryson Halley, Koen K A Van Rompay, Jeffrey Roberts

Journal: J Med Primatol

PubMed ID: 35794847

Doi: 10.1111/jmp.12604

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Correction: High level SARS-CoV-2 nucleocapsid refolding using mild condition for inclusion bodies solubilization: Application of high pressure at pH 90

Authors:

Journal: PLoS ONE

PubMed ID: 35788214

Doi: 10.1371/journal.pone.0271140

Products & Services: PCR Cloning and Subcloning

CaMKII Inhibition Attenuates Distinct Gain-of-Function Effects Produced by Mutant Nav16 Channels and Reduces Neuronal Excitability

Authors: Agnes S Zybura, Firoj K Sahoo, Andy Hudmon, Theodore R Cummins

Journal: Cells

PubMed ID: 35805192

Doi: 10.3390/cells11132108

Products & Services: Mammalian Expression

Efficient multiplex CRISPR/Cpf1 (Cas12a) genome editing system in Aspergillus aculeatus TBRC 277

Authors: Dede Abdulrachman, Verawat Champreda, Lily Eurwilaichitr, Duriya Chantasingh, Kusol Pootanakit

Journal: J Biotechnol

PubMed ID: 35788357

Doi: 10.1016/j.jbiotec.2022.06.011

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Ancestrally Reconstructed von Willebrand Factor Reveals Evidence for Trench Warfare Coevolution between Opossums and Pit Vipers

Authors: Danielle H Drabeck, Alexandra Rucavado, Erika Hingst-Zaher, Antony Dean, Sharon A Jansa

Journal: Mol Biol Evol

PubMed ID: 35723968

Doi: 10.1093/molbev/msac140

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Calcium responses to external mechanical stimuli in the multicellular stage of Dictyostelium discoideum

Authors: Hidenori Hashimura, Yusuke V Morimoto, Yusei Hirayama, Masahiro Ueda

Journal: Sci Rep

PubMed ID: 35859163

Doi: 10.1038/s41598-022-16774-3

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miR-301b-5p and its target gene nfatc2ip regulate inflammatory responses in the liver of rainbow trout (Oncorhynchus mykiss) under high temperature stress

Authors: Tianqing Huang, Wei Gu, Enhui Liu, Bingqian Wang, Gaochao Wang, Fulin Dong, Fuyuan Guo, Wenlong Jiao, Yanchun Sun, Xiance Wang, Shanwei Li, Gefeng Xu

Journal: Ecotoxicol Environ Saf

PubMed ID: 35901591

Doi: 10.1016/j.ecoenv.2022.113915

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An immunodetection assay developed using cobra cytotoxin-specific antibodies: Potential diagnostics for cobra envenoming

Authors: Hui Ling Ong, Choo Hock Tan, Louisa Pernee Lee, Sook Mei Khor, Kae Yi Tan

Journal: Toxicon

PubMed ID: 35868411

Doi: 10.1016/j.toxicon.2022.07.010

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A Single Dose of Anti-HBsAg Antibody-Encoding mRNA-LNPs Suppressed HBsAg Expression: a Potential Cure of Chronic Hepatitis B Virus Infection

Authors: Binfan Chen, Yuchen Chen, Jian Li, Chunyu Wang, Wenping Song, Yumei Wen, Jinzhong Lin, Yanling Wu, Tianlei Ying

Journal: MBio

PubMed ID: 35862767

Doi: 10.1128/mbio.01612-22

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Phage defence by deaminase-mediated depletion of deoxynucleotides in bacteria

Authors: Brian Y Hsueh, Geoffrey B Severin, Clinton A Elg, Evan J Waldron, Abhiruchi Kant, Alex J Wessel, John A Dover, Christopher R Rhoades, Benjamin J Ridenhour, Kristin N Parent, Matthew B Neiditch, Janani Ravi, Eva M Top, Christopher M Waters

Journal: Nat Microbiol

PubMed ID: 35817890

Doi: 10.1038/s41564-022-01162-4

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Sequence grammar underlying the unfolding and phase separation of globular proteins

Authors: Kiersten M Ruff, Yoon Hee Choi, Dezerae Cox, Angelique R Ormsby, Yoochan Myung, David B Ascher, Sheena E Radford, Rohit V Pappu, Danny M Hatters

Journal: Mol Cell

PubMed ID: 35853451

Doi: 10.1016/j.molcel.2022.06.024

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Screening circular RNAs with functional potential using the RfxCas13d/BSJ-gRNA system

Authors: Siqi Li, Hao Wu, Ling-Ling Chen

Journal: Nat Protoc

PubMed ID: 35831613

Doi: 10.1038/s41596-022-00715-5

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SARS-CoV-2 Epitopes following Infection and Vaccination Overlap Known Neutralizing Antibody Sites

Authors: Li Yang, Te Liang, Lane M Pierson, Hongye Wang, Jesse K Fletcher, Shu Wang, Duran Bao, Lili Zhang, Zhen Huang, Wenshu Zheng, Xiaomei Zhang, Heewon Park, Yuwen Li, James E Robinson, Amy K Feehan, Christopher J Lyon, Jing Cao, Lisa A Morici, Chenzhong Li, Chad J Roy, Xiaobo Yu, Tony Hu

Journal: Research (Wash D C)

PubMed ID: 35928300

Doi: 10.34133/2022/9769803

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Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut

Authors: Víctor Taleb, Qinghua Liao, Yoshiki Narimatsu, Ana García-García, Ismael Compañón, Rafael Junqueira Borges, Andrés Manuel González-Ramírez, Francisco Corzana, Henrik Clausen, Carme Rovira, Ramon Hurtado-Guerrero

Journal: Nat Commun

PubMed ID: 35882872

Doi: 10.1038/s41467-022-32021-9

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Phage Particles of Controlled Length and Genome for Targeted Glioblastoma Imaging and Therapeutic Delivery

Authors: Uyanga Tsedev, Ching-Wei Lin, Gaelen T Hess, Jann N Sarkaria, Fred C Lam, Angela M Belcher

Journal: ACS Nano

PubMed ID: 35830573

Doi: 10.1021/acsnano.1c08720

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The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency Pathway

Authors: Lindsay C Sidak-Loftis, Kristin L Rosche, Natasha Pence, Jessica K Ujczo, Joanna Hurtado, Elis A Fisk, Alan G Goodman, Susan M Noh, John W Peters, Dana K Shaw

Journal: MBio

PubMed ID: 35862781

Doi: 10.1128/mbio.00703-22

Products & Services: Mammalian Expression

Conformational landscape of the yeast SAGA complex as revealed by cryo-EM

Authors: Diana Vasyliuk, Joeseph Felt, Ellen D Zhong, Bonnie Berger, Joseph H Davis, Calvin K Yip

Journal: Sci Rep

PubMed ID: 35853968

Doi: 10.1038/s41598-022-16391-0

Products & Services: Proteins, Expression, Isolation and Analysis

Protective effects of small heat shock proteins in Daphnia magna against heavy metal exposure

Authors: Muyi Li, Ting Tang, Fengyu Yuan, Yuming Zhang, Fengchao Li, Fengsong Liu

Journal: Sci Total Environ

PubMed ID: 35907523

Doi: 10.1016/j.scitotenv.2022.157565

Products & Services: Proteins, Expression, Isolation and Analysis

Development and applications of a TaqMan based quantitative real-time PCR for the rapid detection of Pigeon circovirus (PiCV)

Authors: Babu K Nath, Shubhagata Das, Tridip Das, Jade K Forwood, Shane R Raidal

Journal: J Virol Methods

PubMed ID: 35870671

Doi: 10.1016/j.jviromet.2022.114588

Products & Services: Proteins, Expression, Isolation and Analysis

Cholesterol Deprivation Drives DHEA Biosynthesis in Human Adrenals

Authors: Emanuele Pignatti, Emre Murat Altinkilic, Konstantin Bräutigam, Michael Grössl, Aurel Perren, Mihaela Zavolan, Christa E Flück

Journal: Endocrinology

PubMed ID: 35583599

Doi: 10.1210/endocr/bqac076

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An Engineered λ Phage Enables Enhanced and Strain-Specific Killing of Enterohemorrhagic Escherichia coli

Authors: Menglu Jin, Jingchao Chen, Xueyang Zhao, Guoru Hu, Hailei Wang, Zhi Liu, Wei-Hua Chen

Journal: Microbiol Spectr

PubMed ID: 35876591

Doi: 10.1128/spectrum.01271-22

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Development and Assessment of Herpes Simplex Virus Type 1 (HSV-1) Amplicon Vectors with Sensory Neuron-Selective Promoters

Authors: Charles Joussain, Olivier Le Coz, Andrey Pichugin, Peggy Marconi, Filip Lim, Mariaconcetta Sicurella, Keith Foster, François Giuliano, Alberto L Epstein, Alejandro Aranda Muñoz

Journal: Int J Mol Sci

PubMed ID: 35955608

Doi: 10.3390/ijms23158474

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Impacts of a Zwitterionic Peptide on its Fusion Protein

Authors: Patrick McMullen, Liang Fang, Qi Qiao, Qing Shao, Shaoyi Jiang

Journal: Bioconjug Chem

PubMed ID: 35852436

Doi: 10.1021/acs.bioconjchem.2c00176

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Paraneoplastic Pemphigus Autoantibodies Against C-terminus of Desmoplakin Induced Acantholysis and

Authors: Xue Wang, Rui Wang, Dingfang Bu, Leyi Wang, Yuexin Zhang, Yuan Chang, Chenyang Zhang, Xixue Chen, Xuejun Zhu, Zhi Liu, Mingyue Wang

Journal: Front Immunol

PubMed ID: 35911677

Doi: 10.3389/fimmu.2022.886226

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In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus

Authors: Linda B Oyama, Hamza Olleik, Ana Carolina Nery Teixeira, Matheus M Guidini, James A Pickup, Brandon Yeo Pei Hui, Nicolas Vidal, Alan R Cookson, Hannah Vallin, Toby Wilkinson, Denise M S Bazzolli, Jennifer Richards, Mandy Wootton, Ralf Mikut, Kai Hilpert, Marc Maresca, Josette Perrier, Matthias Hess, Hilario C Mantovani, Narcis Fernandez-Fuentes, Christopher J Creevey, Sharon A Huws

Journal: NPJ Biofilms Microbiomes

PubMed ID: 35835775

Doi: 10.1038/s41522-022-00320-0

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Rhesus rotavirus receptor-binding site affects high mobility group box 1 release, altering the pathogenesis of experimental biliary atresia

Authors: Sujit K Mohanty, Bryan Donnelly, Haley Temple, Sarah Mowery, Holly M Poling, Jaroslaw Meller, Astha Malik, Monica McNeal, Greg Tiao

Journal: Hepatol Commun

PubMed ID: 35866580

Doi: 10.1002/hep4.2024

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The transient expression of recombinant proteins in plant cell packs facilitates stable isotope labelling for NMR spectroscopy

Authors: Patrick Opdensteinen, Laura E Sperl, Mariam Mohamadi, Nicole Kündgen-Redding, Franz Hagn, Johannes Felix Buyel

Journal: Plant Biotechnol J

PubMed ID: 35702941

Doi: 10.1111/pbi.13873

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The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE mice

Authors: Yishi Shen, Hong-Mei Gu, Lei Zhai, Binxiang Wang, Shucun Qin, Da-Wei Zhang

Journal: Biochim Biophys Acta Mol Cell Biol Lipids

PubMed ID: 35803528

Doi: 10.1016/j.bbalip.2022.159196

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Antitumor efficacy of MUC1-derived variable epitope library treatments in a mouse model of breast cancer

Authors: Josué Odales, Rodolfo Servín-Blanco, Fernando Martínez-Cortés, Jesus Guzman Valle, Allan Noé Domínguez-Romero, Goar Gevorkian, Karen Manoutcharian

Journal: Vaccine

PubMed ID: 35788294

Doi: 10.1016/j.vaccine.2022.06.062

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O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1

Authors: Qiang Zhu, Hong Zhou, Liming Wu, Zhenyuan Lai, Didi Geng, Weiwei Yang, Jie Zhang, Zhiya Fan, Weijie Qin, Yong Wang, Ruhong Zhou, Wen Yi

Journal: Nat Chem Biol

PubMed ID: 35879546

Doi: 10.1038/s41589-022-01085-5

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Reprogramming of Human B Cells from Secreting IgG to IgM by Genome Editing

Authors: Guigao Lin, Kuo Zhang, Yanxi Han, Rongxue Peng, Jiawei Zhang, Dandan Li, Jinming Li

Journal: CRISPR J

PubMed ID: 35900273

Doi: 10.1089/crispr.2021.0093

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Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis

Authors: Nikola Kenjić, Kathleen M Meneely, Daniel J Wherritt, Melissa C Denler, Timothy A Jackson, Graham R Moran, Audrey L Lamb

Journal: J Am Chem Soc

PubMed ID: 35802469

Doi: 10.1021/jacs.2c03376

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Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice

Authors: Yuning Liu, Hong Xing, Alexis F Ernst, Canna Liu, Christian Maugee, Fumiaki Yokoi, Madepalli Lakshmana, Yuqing Li

Journal: Mol Cell Neurosci

PubMed ID: 35843530

Doi: 10.1016/j.mcn.2022.103756

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Tumor-Localized Administration of α-GalCer to Recruit Invariant Natural Killer T Cells and Enhance Their Antitumor Activity against Solid Tumors

Authors: Yan-Ruide Li, Yang Zhou, Matthew Wilson, Adam Kramer, Ryan Hon, Yichen Zhu, Ying Fang, Lili Yang

Journal: Int J Mol Sci

PubMed ID: 35886891

Doi: 10.3390/ijms23147547

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Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge

Authors: Shanna S Leventhal, Kimberly Meade-White, Deepashri Rao, Elaine Haddock, Jacqueline Leung, Dana Scott, Jacob Archer, Samantha Randall, Jesse H Erasmus, Heinz Feldmann, David W Hawman

Journal: EBioMedicine

PubMed ID: 35907368

Doi: 10.1016/j.ebiom.2022.104188

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Development of Melioidosis Subunit Vaccines Using an Enzymatically Inactive Burkholderia pseudomallei AhpC

Authors: Lindsey K Schmidt, Caitlyn E Orne, Teresa L Shaffer, Shane M Wilson, Nittaya Khakhum, Alfredo G Torres, Paul J Brett, Mary N Burtnick

Journal: Infect Immun

PubMed ID: 35862715

Doi: 10.1128/iai.00222-22

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The Patterning and Proportion of Charged Residues in the Arginine-Rich Mixed-Charge Domain Determine the Membrane-Less Organelle Targeted by the Protein

Authors: Tamami Miyagi, Rio Yamazaki, Koji Ueda, Satoshi Narumi, Yuhei Hayamizu, Hiroshi Uji-I, Masahiko Kuroda, Kohsuke Kanekura

Journal: Int J Mol Sci

PubMed ID: 35887012

Doi: 10.3390/ijms23147658

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Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos

Authors: Fanye Meng, Chenxi Xu, Kwang-Su Park, H Ümit Kaniskan, Gang Greg Wang, Jian Jin

Journal: J Med Chem

PubMed ID: 35895319

Doi: 10.1021/acs.jmedchem.2c00807

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Development and characterization of an inducible assay system to measure Zika virus capsid interactions

Authors: Jieshi Yu, Chen Huang, Zhao Wang, Radhey S Kaushik, Zizhang Sheng, Feng Li, Dan Wang

Journal: J Med Virol

PubMed ID: 35822280

Doi: 10.1002/jmv.27991

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SARS-CoV-2 Omicron escapes mRNA vaccine booster-induced antibody neutralisation in patients with autoimmune rheumatic diseases: an observational cohort study

Authors: Woo-Joong Kim, Seong-Ho Choi, Ji Young Park, Jung Soo Song, Jin-Won Chung, Sang Tae Choi

Journal: Ann Rheum Dis

PubMed ID: 35878999

Doi: 10.1136/ard-2022-222689

Bacteria deplete deoxynucleotides to defend against bacteriophage infection

Authors: Nitzan Tal, Adi Millman, Avigail Stokar-Avihail, Taya Fedorenko, Azita Leavitt, Sarah Melamed, Erez Yirmiya, Carmel Avraham, Alexander Brandis, Tevie Mehlman, Gil Amitai, Rotem Sorek

Journal: Nat Microbiol

PubMed ID: 35817891

Doi: 10.1038/s41564-022-01158-0

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RG203KR Mutations in SARS-CoV-2 Nucleocapsid: Assessing the Impact Using a Virus-Like Particle Model System

Authors: Harsha Raheja, Soma Das, Anindita Banerjee, Dikshaya P, Deepika C, Debanjan Mukhopadhyay, Subbaraya G Ramachandra, Saumitra Das

Journal: Microbiol Spectr

PubMed ID: 35862952

Doi: 10.1128/spectrum.00781-22

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Development of an in-house quantitative ELISA for the evaluation of different Covid-19 vaccines in humans

Authors: Mariem Gdoura, Fatma Ben Ghaloum, Meriem Ben Hamida, Wafa Chamsa, Henda Triki, Chokri Bahloul

Journal: Sci Rep

PubMed ID: 35788676

Doi: 10.1038/s41598-022-15378-1

In situ architecture of the lipid transport protein VPS13C at ER-lysosome membrane contacts

Authors: Shujun Cai, Yumei Wu, Andrés Guillén-Samander, William Hancock-Cerutti, Jun Liu, Pietro De Camilli

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35858323

Doi: 10.1073/pnas.2203769119

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Immunogenicity of the third and fourth BNT162b2 mRNA COVID-19 boosters and factors associated with immune response in patients with SLE and rheumatoid arthritis

Authors: Theerada Assawasaksakul, Seelwan Sathitratanacheewin, Preeyaporn Vichaiwattana, Nasamon Wanlapakorn, Yong Poovorawan, Yingyos Avihingsanon, Nawaporn Assawasaksakul, Wonngarm Kittanamongkolchai

Journal: Lupus Sci Med

PubMed ID: 35902168

Doi: 10.1136/lupus-2022-000726

HOXB5-activated ANGPT2 promotes the proliferation, migration, invasion and angiogenic effect of esophageal cancer cells via activating ERK/AKT signaling pathway

Authors: Jing Li, Shanshan Gao

Journal: Exp Ther Med

PubMed ID: 35949323

Doi: 10.3892/etm.2022.11522

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The Relative Positioning of B and T Cell Epitopes Drives Immunodominance

Authors: Riccardo Biavasco, Marco De Giovanni

Journal: Vaccines (Basel)

PubMed ID: 36016115

Doi: 10.3390/vaccines10081227

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Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation

Authors: Charline Mary, Mona Hoseini Soflaee, Rushendhiran Kesavan, Muriel Gelin, Harrison Brown, G Zacharias, Thomas P Mathews, Andrew Lemoff, Corinne Lionne, Gilles Labesse, Gerta Hoxhaj

Journal: Mol Cell

PubMed ID: 35868311

Doi: 10.1016/j.molcel.2022.06.026

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A Novel Cre/lox71-Based System for Inducible Expression of Recombinant Proteins and Genome Editing

Authors: Maxim Karagyaur, Daniyar Dyikanov, Pyotr Tyurin-Kuzmin, Stalik Dzhauari, Mariya Skryabina, Maksim Vigovskiy, Alexandra Primak, Natalia Kalinina, Vsevolod Tkachuk

Journal: Cells

PubMed ID: 35883584

Doi: 10.3390/cells11142141

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Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis

Authors: Yize Liu, Guanzhen Qiu, Yinzhou Luo, Shanshan Li, Yeqiu Xu, Yuanzhuang Zhang, Jiayuan Hu, Peifeng Li, Hai Pan, Yong Wang

Journal: Exp Mol Med

PubMed ID: 35879346

Doi: 10.1038/s12276-022-00806-z

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Large-scale application of free energy perturbation calculations for antibody design

Authors: Fangqiang Zhu, Feliza A Bourguet, William F D Bennett, Edmond Y Lau, Kathryn T Arrildt, Brent W Segelke, Adam T Zemla, Thomas A Desautels, Daniel M Faissol

Journal: Sci Rep

PubMed ID: 35864134

Doi: 10.1038/s41598-022-14443-z

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Analysis of FR901379 Biosynthetic Genes in by Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Based Genomic Manipulation

Authors: Teng-Yun Wei, Yan Zheng, Miyang Wan, Songbai Yang, Jiawei Tang, Yuanjie Wu, Jiyang Li, Shao-Xin Chen

Journal: ACS Chem Biol

PubMed ID: 35822391

Doi: 10.1021/acschembio.2c00250

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Relaxin Affects Airway Remodeling Genes Expression through Various Signal Pathways Connected with Transcription Factors

Authors: Joanna Wieczfinska, Rafal Pawliczak

Journal: Int J Mol Sci

PubMed ID: 35955554

Doi: 10.3390/ijms23158413

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NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections

Authors: Philippe Rascle, Cyril Planchais, Béatrice Jacquelin, Marie Lazzerini, Vanessa Contreras, Caroline Passaes, Asier Saez-Cirion, Hugo Mouquet, Nicolas Huot, Michaela Müller-Trutwin

Journal: Commun Biol

PubMed ID: 35798936

Doi: 10.1038/s42003-022-03619-y

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Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures

Authors: Marlen Kruse, Basma Altattan, Eva-Maria Laux, Nico Grasse, Lars Heinig, Christin Möser, David M Smith, Ralph Hölzel

Journal: Sci Rep

PubMed ID: 35896714

Doi: 10.1038/s41598-022-16914-9

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Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes

Authors: Jean Mukherjee, Celinia A Ondeck, Jacqueline M Tremblay, Jacob Archer, Michelle Debatis, Alexa Foss, Junya Awata, Jesse H Erasmus, Patrick M McNutt, Charles B Shoemaker

Journal: Sci Rep

PubMed ID: 35803998

Doi: 10.1038/s41598-022-15876-2

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Neutralizing antibody responses against SARS-CoV-2 in patients with plasma cell disorders who are on active treatment after two doses of mRNA vaccination

Authors: Al-Ola Abdallah, Zahra Mahmoudjafari, Tahani Atieh, Nausheen Ahmed, Wei Cui, Leyla Shune, Meera Mohan, Joseph McGuirk, Cassie Remker, Margaret Foss, Ellie Karloff, Heather Fitch, Shebli Atrash

Journal: Eur J Haematol

PubMed ID: 35810359

Doi: 10.1111/ejh.13826

Highly Effective Markerless Genetic Manipulation of Using a Mutated PheS-Based Counterselectable Marker

Authors: Guangjuan Gao, Dong Wei, Gang Li, Ping Chen, Liujun Wu, Siguo Liu, Yueling Zhang

Journal: Front Microbiol

PubMed ID: 35910605

Doi: 10.3389/fmicb.2022.947821

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CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7

Authors: Yong Zi Tan, Yazan M Abbas, Jing Ze Wu, Di Wu, Kristine A Keon, Geoffrey G Hesketh, Stephanie A Bueler, Anne-Claude Gingras, Carol V Robinson, Sergio Grinstein, John L Rubinstein

Journal: Life Sci Alliance

PubMed ID: 35794005

Doi: 10.26508/lsa.202201527

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ArsR Family Regulator MSMEG_6762 Mediates the Programmed Cell Death by Regulating the Expression of HNH Nuclease in Mycobacteria

Authors: Xiangke Duan, Xue Huang, Junqi Xu, Xue Li, Jingjing Niu, Xiaoli Du, Xiaoyu Wang, Jiang Li, Michael Kelly, Jiaohan Guo, Ke Zhang, Yu Huang, Biao Kan, Jianping Xie

Journal: Microorganisms

PubMed ID: 36013953

Doi: 10.3390/microorganisms10081535

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Silencing lncRNA 93358 Inhibits the Apoptosis of Myocardial Cells in Myocardial Infarction Rats by Inducing the Expression of SLC8A1

Authors: Jiumei Cai, Xiaoping Wang, Wei Liao, Yiming Zhong, Lingling Chen, Zhiwei Zhang

Journal: Biomed Res Int

PubMed ID: 35845941

Doi: 10.1155/2022/1138709

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Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism

Authors: Yong-Gang Chang, Christopher J Lupton, Charles Bayly-Jones, Alastair C Keen, Laura D'Andrea, Christina M Lucato, Joel R Steele, Hari Venugopal, Ralf B Schittenhelm, James C Whisstock, Michelle L Halls, Andrew M Ellisdon

Journal: Nat Struct Mol Biol

PubMed ID: 35864164

Doi: 10.1038/s41594-022-00804-9

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Diminished T-cell immune responses to SARS-CoV-2 omicron variant after BNT162b2 vaccination

Authors: Stanley C Jordan, Bong-Ha Shin, Edgar Rodriguez, Ashley Vo, Ruan Zhang

Journal: Immunol Lett

PubMed ID: 35843362

Doi: 10.1016/j.imlet.2022.07.004

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CC chemokine receptor 5 antagonist alleviates inflammation by regulating IFN-γ/IL-10 and STAT4/Smad3 signaling in a mouse model of autoimmune encephalomyelitis

Authors: Sheikh F Ahmad, Ahmed Nadeem, Mushtaq A Ansari, Saleh A Bakheet, Mudassar Shahid, Haneen A Al-Mazroua, Homood M As Sobeai, Abdullah F Alasmari, Mohammed M Alanazi, Abdullah S Alhamed, Abdullah A Aldossari, Sabry M Attia

Journal: Cell Immunol

PubMed ID: 35872534

Doi: 10.1016/j.cellimm.2022.104580

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Intranasal administration of a live-attenuated recombinant newcastle disease virus expressing the SARS-CoV-2 Spike protein induces high neutralizing antibody levels and protects from experimental challenge infection in hamsters

Authors: Rik L de Swart, Olav S de Leeuw, Nadia Oreshkova, Nora M Gerhards, Irina C Albulescu, Sandra Vreman, José L Gonzales, Riks Maas, Frank J M van Kuppeveld, Peter Soema, Berend-Jan Bosch, Ben P H Peeters

Journal: Vaccine

PubMed ID: 35820941

Doi: 10.1016/j.vaccine.2022.07.005

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Persistent Reptarenavirus and Hartmanivirus Infection in Cultured Boid Cells

Authors: Annika Lintala, Leonora Szirovicza, Anja Kipar, Udo Hetzel, Jussi Hepojoki

Journal: Microbiol Spectr

PubMed ID: 35862992

Doi: 10.1128/spectrum.01585-22

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Characterization of Dense Granule Metalloproteinase INS-16 in

Authors: Hao Cui, Rui Xu, Yu Li, Yaqiong Guo, Ziding Zhang, Lihua Xiao, Yaoyu Feng, Na Li

Journal: Int J Mol Sci

PubMed ID: 35886965

Doi: 10.3390/ijms23147617

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Translating a Thin-Film Rehydration Method to Microfluidics for the Preparation of a SARS-CoV-2 DNA Vaccine: When Manufacturing Method Matters

Authors: Allegra Peletta, Eakachai Prompetchara, Kittipan Tharakhet, Papatsara Kaewpang, Supranee Buranapraditkun, Nongnaphat Yostrerat, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Jonathan Avaro, Leonard Krupnik, Antonia Neels, Kiat Ruxrungtham, Chutitorn Ketloy, Gerrit Borchard

Journal: Pharmaceutics

PubMed ID: 35890321

Doi: 10.3390/pharmaceutics14071427

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From functional genomics of vero cells to CRISPR-based genomic deletion for improved viral production rates

Authors: Marie-Angélique Sène, Yu Xia, Amine A Kamen

Journal: Biotechnol Bioeng

PubMed ID: 35869699

Doi: 10.1002/bit.28190

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Interaction of Liberibacter Solanacearum with Host Psyllid Vitellogenin and Its Association with Autophagy

Authors: Poulami Sarkar, Murad Ghanim

Journal: Microbiol Spectr

PubMed ID: 35863005

Doi: 10.1128/spectrum.01577-22

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Genetic diversity of collaborative cross mice enables identification of novel rift valley fever virus encephalitis model

Authors: Haley N Cartwright, Dominique J Barbeau, Joshua D Doyle, Ed Klein, Mark T Heise, Martin T Ferris, Anita K McElroy

Journal: PLoS Pathog

PubMed ID: 35834486

Doi: 10.1371/journal.ppat.1010649

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Peptide-siRNA nanoparticles targeting NF-κB p50 mitigate experimental abdominal aortic aneurysm progression and rupture

Authors: Huimin Yan, Ying Hu, Antonina Akk, Samuel A Wickline, Hua Pan, Christine T N Pham

Journal: Biomater Adv

PubMed ID: 35891603

Doi: 10.1016/j.bioadv.2022.213009

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Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2

Authors: Mariana F Tioni, Robert Jordan, Angie Silva Pena, Aditya Garg, Danlu Wu, Shannon I Phan, Christopher M Weiss, Xing Cheng, Jack Greenhouse, Tatyana Orekov, Daniel Valentin, Swagata Kar, Laurent Pessaint, Hanne Andersen, Christopher C Stobart, Melissa H Bloodworth, R Stokes Peebles, Yang Liu, Xuping Xie, Pei-Yong Shi, Martin L Moore, Roderick S Tang

Journal: npj Vaccines

PubMed ID: 35906244

Doi: 10.1038/s41541-022-00509-6

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Polymeric nanoparticles for dual-targeted theranostic gene delivery to hepatocellular carcinoma

Authors: Hannah J Vaughan, Camila G Zamboni, Laboni F Hassan, Nicholas P Radant, Desmond Jacob, Ronnie C Mease, Il Minn, Stephany Y Tzeng, Kathleen L Gabrielson, Pranshu Bhardwaj, Xin Guo, David Francisco, Martin G Pomper, Jordan J Green

Journal: Sci Adv

PubMed ID: 35857843

Doi: 10.1126/sciadv.abo6406

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Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents

Authors: Jiyun Zhu, Linfeng Li, Aleksandra Drelich, Bala C Chenna, Drake M Mellott, Zane W Taylor, Vivian Tat, Christopher Z Garcia, Ardala Katzfuss, Chien-Te K Tseng, Thomas D Meek

Journal: Front Chem

PubMed ID: 35860632

Doi: 10.3389/fchem.2022.867928

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HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations

Authors: Yong Du, Yongfeng Chen, Yuxia Wang, Jinju Chen, Xiaorong Lu, Li Zhang, Yan Li, Zhaofu Wang, Guozhong Ye, George Zhang

Journal: Mol Cancer Ther

PubMed ID: 35499406

Doi: 10.1158/1535-7163.MCT-21-0835

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Ligand-induced transmembrane conformational coupling in monomeric EGFR

Authors: Shwetha Srinivasan, Raju Regmi, Xingcheng Lin, Courtney A Dreyer, Xuyan Chen, Steven D Quinn, Wei He, Matthew A Coleman, Kermit L Carraway, Bin Zhang, Gabriela S Schlau-Cohen

Journal: Nat Commun

PubMed ID: 35794108

Doi: 10.1038/s41467-022-31299-z

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Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis

Authors: Wenli Liu, Nataliya Östberg, Mustafa Yalcinkaya, Huijuan Dou, Kaori Endo-Umeda, Yang Tang, Xintong Hou, Tong Xiao, Trevor P Fidler, Sandra Abramowicz, Yong-Guang Yang, Oliver Soehnlein, Alan R Tall, Nan Wang

Journal: J Clin Invest

PubMed ID: 35587375

Doi: 10.1172/JCI155724

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Construction of a Novel Clinical Stage-Related Gene Signature for Predicting Outcome and Immune Response in Hepatocellular Carcinoma

Authors: Liu Yang, Long-Fei Zeng, Guo-Qing Hong, Qing Luo, Xing Lai

Journal: J Immunol Res

PubMed ID: 35865652

Doi: 10.1155/2022/6535009

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Apela gene therapy alleviates pulmonary hypertension in rats

Authors: Yuexin Hu, Liangli Jin, Yang Pan, Jue Zou, Zhi Wang

Journal: FASEB J

PubMed ID: 35747913

Doi: 10.1096/fj.202200266R

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Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Authors: Gamma Chi , Qiansheng Liang , Akshay Sridhar , John B Cowgill , Kasim Sader , Mazdak Radjainia , Pu Qian , Pablo Castro-Hartmann , Shayla Venkaya , Nanki Kaur Singh , Gavin McKinley , Alejandra Fernandez-Cid , Shubhashish M M Mukhopadhyay , Nicola A Burgess-Brown , Lucie Delemotte , Manuel Covarrubias , Katharina L Dürr

Journal: Nat Commun

PubMed ID: 35840580

Doi: 10.1038/s41467-022-29594-w

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Induction of Broadly Cross-Reactive Antibody Responses to SARS-CoV-2 Variants by S1 Nanoparticle Vaccines

Authors: Cong Sun , Run-Yu Yuan , Chu Xie , Jiu-Feng Sun , Xin-Yan Fang , Yi-Sha Hu , Xiao-Hui Yu, Zheng Liu , Mu-Sheng Zeng , Yin-Feng Kang

Journal: J Virol

PubMed ID: 35699445

Doi: 10.1128/jvi.00383-22

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A precise and efficient adenine base editor

Authors: Tianxiang Tu , Zongming Song , Xiaoyu Liu , Shengxing Wang , Xiaoxue He , Haitao Xi , Jiahua Wang , Tong Yan , Haoran Chen , Zhenwu Zhang , Xiujuan Lv , Jineng Lv , Xiu-Feng Huang , Junzhao Zhao , Chao-Po Lin , Caixia Gao , Jinwei Zhang , Feng Gu

Journal: Mol Ther

PubMed ID: 35821638

Doi: 10.1016/j.ymthe.2022.07.010

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Native Glucagon Amyloids Catalyze Key Metabolic Reactions

Authors: Elad Arad , Gal Yosefi , Sofiya Kolusheva , Ronit Bitton , Hanna Rapaport , Raz Jelinek

Journal: ACS Nano

PubMed ID: 35866668

Doi: 10.1021/acsnano.2c05166

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Rational development of a combined mRNA vaccine against COVID-19 and influenza

Authors: Qing Ye , Mei Wu , Chao Zhou , Xishan Lu , Baoying Huang , Ning Zhang , Hui Zhao , Hang Chi , Xiaojing Zhang , Dandan Ling , Rong-Rong Zhang , Zhuofan Li , Dan Luo , Yi-Jiao Huang , Hong-Ying Qiu , Haifeng Song , Wenjie Tan , Ke Xu , Bo Ying , Cheng-Feng Qin

Journal: npj Vaccines

PubMed ID: 35882870

Doi: 10.1038/s41541-022-00478-w

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Detection of Nipah and Hendra Viruses Using Recombinant Human Ephrin B2 Capture Virus in Immunoassays

Authors: Ming Yang , Wenjun Zhu , Thang Truong , Bradley Pickering , Shawn Babiuk , Darwyn Kobasa , Logan Banadyga

Journal: Viruses

PubMed ID: 36016279

Doi: 10.3390/v14081657

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Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults

Authors: Hassen Kared, Asia-Sophia Wolf, Amin Alirezaylavasani, Anthony Ravussin, Guri Solum, Trung The Tran, Fridtjof Lund-Johansen, John Torgils Vaage, Lise Sofie Nissen-Meyer, Unni C Nygaard, Olav Hungnes, Anna H Robertson, Lisbeth Meyer Næss, Lill Trogstad, Per Magnus, Ludvig A Munthe, Siri Mjaaland

Journal: Nat Commun

PubMed ID: 35851055

Doi: 10.1038/s41467-022-31888-y

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Comprehensive Evaluation and Comparison of Machine Learning Methods in QSAR Modeling of Antioxidant Tripeptides

Authors: Zhenjiao Du, Donghai Wang, Yonghui Li

Journal: ACS Omega

PubMed ID: 35910147

Doi: 10.1021/acsomega.2c03062

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Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis

Authors: Zachary Armstrong, Richard W Meek, Liang Wu, James N Blaza, Gideon J Davies

Journal: Structure

PubMed ID: 35907402

Doi: 10.1016/j.str.2022.07.001

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