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Cap Is the Protease of the Porcine Circovirus 2

Authors: Xuechen Yang, Wei Yang, Wei Zhang, Jiamei Li, Guoyu Yang, Shuhong Zhao, Yueting Zheng

Journal: Viruses

PubMed ID: 35891530

Doi: 10.3390/v14071550

Products & Services: Proteins, Expression, Isolation and Analysis

A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins

Authors: Noureddine Lazar, Carl H Mesarich, Yohann Petit-Houdenot, Nacera Talbi, Ines Li de la Sierra-Gallay, Emilie Zélie, Karine Blondeau, Jérôme Gracy, Bénédicte Ollivier, Françoise Blaise, Thierry Rouxel, Marie-Hélène Balesdent, Alexander Idnurm, Herman van Tilbeurgh, Isabelle Fudal

Journal: PLoS Pathog

PubMed ID: 35793393

Doi: 10.1371/journal.ppat.1010664

Products & Services: Proteins, Expression, Isolation and Analysis

Phase transition modulation and biophysical characterization of biomolecular condensates using microfluidics

Authors: Katherine W Y Chan, Maryam Navi, Jennifer Kieda, Thomas Moran, Daniel Hammers, Shaun Lee, Scott S H Tsai

Journal: Lab Chip

PubMed ID: 35616128

Doi: 10.1039/d2lc00037g

Products & Services: Proteins, Expression, Isolation and Analysis

Theaflavin-3,3'-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells

Authors: Yichen Wu, Min Chen, Zilong Chen, Jiangcheng Shu, Luoying Zhang, Jiong Hu, Hongjun Yu, Kai Huang, Minglu Liang

Journal: Front Pharmacol

PubMed ID: 35903325

Doi: 10.3389/fphar.2022.861319

Products & Services: Recombinant Proteins

CROWN ROOTLESS1 binds DNA with a relaxed specificity and activates OsROP and OsbHLH044 genes involved in crown root formation in rice

Authors: Mathieu Gonin, Kwanho Jeong, Yoan Coudert, Jeremy Lavarenne, Giang Thi Hoang, Martine Bes, Huong Thi Mai To, Marie-Rose Ndella Thiaw, Toan Van Do, Daniel Moukouanga, Soazig Guyomarc'h, Kevin Bellande, Jean-Rémy Brossier, Boris Parizot, Hieu Trang Nguyen, Tom Beeckman, Véronique Bergougnoux, Jacques Rouster, Christophe Sallaud, Laurent Laplaze, Antony Champion, Pascal Gantet

Journal: Plant J

PubMed ID: 35596715

Doi: 10.1111/tpj.15838

Products & Services: Mutant Libraries

Mining Amphibian and Insect Transcriptomes for Antimicrobial Peptide Sequences with rAMPage

Authors: Diana Lin, Darcy Sutherland, Sambina Islam Aninta, Nathan Louie, Ka Ming Nip, Chenkai Li, Anat Yanai, Lauren Coombe, René L Warren, Caren C Helbing, Linda M N Hoang, Inanc Birol

Journal: Antibiotics (Basel)

PubMed ID: 35884206

Doi: 10.3390/antibiotics11070952

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Cross-variant protection against SARS-CoV-2 infection in hamsters immunized with monovalent and bivalent inactivated vaccines

Authors: Zi-Wei Ye, Yilan Fan, Kaiming Tang, Chon Phin Ong, Cuiting Luo, Hon-Lam Chung, Tsun-Lam Leong, Ronghui Liang, Wai-Yin Lui, Runhong Zhou, Yun Cheng, Lu Lu, Pak-Hin Hinson Cheung, Jasper Fuk-Woo Chan, Zhiwei Chen, Kwok-Yung Yuen, Shuofeng Yuan, Kelvin Kai-Wang To, Dong-Yan Jin

Journal: Int J Biol Sci

PubMed ID: 35874942

Doi: 10.7150/ijbs.72109

Biglycan neo-epitope (BGN), a novel biomarker for screening early changes in equine osteoarthritic subchondral bone

Authors: S Adepu, S Ekman, J Leth, U Johansson, A Lindahl, E Skiöldebrand

Journal: Osteoarthritis Cartilage

PubMed ID: 35870736

Doi: 10.1016/j.joca.2022.07.005

Products & Services: Proteins, Expression, Isolation and Analysis

Comparative analysis of human immune responses following SARS-CoV-2 vaccination with BNT162b2, mRNA-1273, or Ad26COV2S

Authors: Dominique J Barbeau, Judith M Martin, Emily Carney, Emily Dougherty, Joshua D Doyle, Terence S Dermody, Alejandro Hoberman, John V Williams, Marian G Michaels, John F Alcorn, W Paul Duprex, Anita K McElroy

Journal: npj Vaccines

PubMed ID: 35794181

Doi: 10.1038/s41541-022-00504-x

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FOXM1 regulates glycolysis and energy production in multiple myeloma

Authors: Yan Cheng, Fumou Sun, Krista Thornton, Xuefang Jing, Jing Dong, Grant Yun, Michael Pisano, Fenghuang Zhan, Sung Hoon Kim, John A Katzenellenbogen, Benita S Katzenellenbogen, Parameswaran Hari, Siegfried Janz

Journal: Oncogene

PubMed ID: 35794249

Doi: 10.1038/s41388-022-02398-4

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Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a live biotherapeutic for phenylketonuria

Authors: Yu Jiang, Bingbing Sun, Fenghui Qian, Feng Dong, Chongmao Xu, Wuling Zhong, Rui Huang, Qiwei Zhai, Yu Jiang, Sheng Yang

Journal: Sci China Life Sci

PubMed ID: 35907113

Doi: 10.1007/s11427-021-2137-3

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Microfluidic Paper-Based Preconcentration and Retrieval for Rapid Ribonucleic Acid Biomarker Detection and Visualization

Authors: Yannan Yu, Fengya Fan, Zachary J Smith, Xi Wei

Journal: Anal Chem

PubMed ID: 35858837

Doi: 10.1021/acs.analchem.2c01442

Products & Services: Molecular Biology Tools

Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster model

Authors: Kyle Rosenke, Atsushi Okumura, Matthew C Lewis, Friederike Feldmann, Kimberly Meade-White, W Forrest Bohler, Amanda Griffin, Rebecca Rosenke, Carl Shaia, Michael A Jarvis, Heinz Feldmann

Journal: JCI Insight

PubMed ID: 35579953

Doi: 10.1172/jci.insight.160108

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HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS

Authors: Elke Braems, Valérie Bercier, Evelien Van Schoor, Kara Heeren, Jimmy Beckers, Laura Fumagalli, Lieselot Dedeene, Matthieu Moisse, Ilse Geudens, Nicole Hersmus, Arpan R Mehta, Bhuvaneish T Selvaraj, Siddharthan Chandran, Ritchie Ho, Dietmar R Thal, Philip Van Damme, Bart Swinnen, Ludo Van Den Bosch

Journal: Acta Neuropathol

PubMed ID: 35895140

Doi: 10.1007/s00401-022-02471-y

Products & Services: Proteins, Expression, Isolation and Analysis

KIL1 terminates fertility in maize by controlling silk senescence

Authors: M Ria Šim Škov, Anna Daneva, Nicolas Doll, Neeltje Schilling, Marta Cubr A-Rad O, Liangzi Zhou, Freya De Winter, Stijn Aesaert, Riet De Rycke, Laurens Pauwels, Thomas Dresselhaus, Norbert Brugi Re, Carl R Simmons, Jeffrey E Habben, Moritz K Nowack

Journal: Plant Cell

PubMed ID: 35608197

Doi: 10.1093/plcell/koac151

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The structure of Vibrio cholerae FeoC reveals conservation of the helix-turn-helix motif but not the cluster-binding domain

Authors: Janae B Brown, Mark A Lee, Aaron T Smith

Journal: J Biol Inorg Chem

PubMed ID: 35796835

Doi: 10.1007/s00775-022-01945-4

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma

Authors: Ryan J Boyd, Tien L Olson, James D Zook, Derek Stein, Manuel Aceves, Wan-Hsin Lin, Felicia M Craciunescu, Debra T Hansen, Panos Z Anastasiadis, Abhishek Singharoy, Petra Fromme

Journal: FASEB J

PubMed ID: 35639414

Doi: 10.1096/fj.202101808RR

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Optimization and validation of CAR transduction into human primary NK cells using CRISPR and AAV

Authors: Meisam Naeimi Kararoudi, Shibi Likhite, Ezgi Elmas, ..., Branden S. Moriarity, Kathrin Meyer, Dean A. Lee

Journal: CellPress

Doi: crmeth.2022.100236

Products & Services: Plasmid DNA Preparation

Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway.

Authors: Shenglong Zhu, Jingwei Zhang, Xuan Jiang, Wei Wang, Yong Q Chen

Journal: EBioMedicine

PubMed ID: 35588628

Doi: 10.1016/j.ebiom.2022.104060

Products & Services: PCR Cloning and Subcloning

Agrochemical control of gene expression using evolved split RNA polymerase

Authors: Yuan Yuan , Jin Miao

Journal: PeerJ

PubMed ID: 35729907

Doi: doi.org/10.7717/peerj.13619

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Nociceptor Neurons are Involved in the Host Response to Urinary Tract Infections

Authors: Zhengdong Gao, Yaxiao Liu, Lekai Zhang, Zizhuo Yang, Linchen Lv, Shuai Wang, Lipeng Chen, Nan Zhou, Yaofeng Zhu, Xuewen Jiang, Benkang Shi, Yan Li

Journal: J Inflamm Res

PubMed ID: 35702548

Doi: 10.2147/JIR.S356960

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Humoral and Cellular Responses to BNT162b2 as a Booster Following Two Doses of ChAdOx1 nCov-19 Determined Using Three SARS-CoV-2 Antibody Assays and an Interferon-Gamma Release Assay: A Prospective Longitudinal Study in Healthcare Workers

Authors: Seri Jeong, Nuri Lee, Su Kyung Lee, Eun-Jung Cho, Jungwon Hyun, Min-Jeong Park, Wonkeun Song, Hyun Soo Kim

Journal: Front Immunol

PubMed ID: 35720318

Doi: 10.3389/fimmu.2022.859019

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Using field evaluation and systematic iteration to rationalize the accumulation of omega-3 long-chain polyunsaturated fatty acids in transgenic Camelina sativa

Authors: Lihua Han, Susana Silvestre, Olga Sayanova, Richard P Haslam, Johnathan A Napier

Journal: Plant Biotechnol J

PubMed ID: 35656640

Doi: 10.1111/pbi.13867

Products & Services: Codon Optimization

Visualizing molecules of functional profilin

Authors: Morgan L Pimm, Xinbei Liu, Farzana Tuli, Jennifer Heritz, Ashley Lojko, Jessica L Henty-Ridilla

Journal: Elife

PubMed ID: 35666129

Doi: 10.7554/eLife.76485

Products & Services: Gene Synthesis

Synergistic interaction of Cry1Ah and Vip3Aa19 proteins combination with midgut ATP-binding cassette subfamily C receptors of Conogethes punctiferalis (Guenée) (Lepidoptera: Crambidae)

Authors: Su Mon Shwe, Sivaprasath Prabu, Dapeng Jing, Kanglai He, Zhenying Wang

Journal: Int J Biol Macromol

PubMed ID: 35690160

Doi: 10.1016/j.ijbiomac.2022.06.019

Products & Services: Proteins, Expression, Isolation and Analysis

Circular ribonucleic acid nucleoporin 98 knockdown alleviates high glucose-induced proliferation, fibrosis, inflammation and oxidative stress in human glomerular mesangial cells by regulating the microribonucleic acid-151-3p-high mobility group AT-hook 2 axis

Authors: Qianlan Dong, Longhao Dong, Yanting Zhu, Xiaoming Wang, Zhenjiang Li, Linping Zhang

Journal: J Diabetes Investig

PubMed ID: 35482475

Doi: 10.1111/jdi.13821

Products & Services: Recombinant Proteins

Tomato brown rugose fruit virus resistance generated by quadruple knockout of homologs of TOBAMOVIRUS MULTIPLICATION1 in tomato

Authors: Masayuki Ishikawa, Tetsuya Yoshida, Momoko Matsuyama, Yusuke Kouzai, Akihito Kano, Kazuhiro Ishibashi

Journal: Plant Physiol

PubMed ID: 35262730

Doi: 10.1093/plphys/kiac103

Products & Services: PCR Cloning and Subcloning

Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y

Authors: Yichao Zhu, Wenzhao Zhou, Zubiao Niu, Jiayi Sun, Zhengrong Zhang, Qinqin Li, You Zheng, Chenxi Wang, Lihua Gao, Qiang Sun

Journal: Biol Direct

PubMed ID: 35658928

Doi: 10.1186/s13062-022-00325-x

Products & Services: Mutant Libraries

Identification of Reference Genes for Reverse Transcription-Quantitative PCR Analysis of Ginger Under Abiotic Stress and for Postharvest Biology Studies

Authors: Gang Li, Jiawei Ma, Junliang Yin, Fengling Guo, Keyong Xi, Peihua Yang, Xiaodong Cai, Qie Jia, Lu Li, Yiqing Liu, Yongxing Zhu

Journal: Front Plant Sci

PubMed ID: 35734245

Doi: 10.3389/fpls.2022.893495

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A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse sera

Authors: Chotiwat Seephetdee, Kanit Bhukhai, Nattawut Buasri, Puttipatch Leelukkanaveera, Pat Lerdwattanasombat, Suwimon Manopwisedjaroen, Nut Phueakphud, Sakonwan Kuhaudomlarp, Eduardo Olmedillas, Erica Ollmann Saphire, Arunee Thitithanyanont, Suradej Hongeng, Patompon Wongtrakoongate

Journal: Antiviral Res

PubMed ID: 35772601

Doi: 10.1016/j.antiviral.2022.105370

Products & Services: Codon Optimization

Peptidoglycan maturation controls outer membrane protein assembly

Authors: Gideon Mamou, Federico Corona, Ruth Cohen-Khait, Nicholas G Housden, Vivian Yeung, Dawei Sun, Pooja Sridhar, Manuel Pazos, Timothy J Knowles, Colin Kleanthous, Waldemar Vollmer

Journal: Nature

PubMed ID: 35705811

Doi: 10.1038/s41586-022-04834-7

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Overproduction, Purification, and Stability of the Functionally Active Human Carnitine Acetyl Transferase

Authors: Deborah Giudice, Lara Console, Arduino Arduini, Cesare Indiveri

Journal: Mol Biotechnol

PubMed ID: 35727434

Doi: 10.1007/s12033-022-00522-z

Products & Services: PCR Cloning and Subcloning

Genomic insights into the recent chromosome reduction of autopolyploid sugarcane Saccharum spontaneum

Authors: Qing Zhang, Yiying Qi, Haoran Pan, Haibao Tang, Gang Wang, Xiuting Hua, Yongjun Wang, Lianyu Lin, Zhen Li, Yihan Li, Fan Yu, Zehuai Yu, Yongji Huang, Tianyou Wang, Panpan Ma, Meijie Dou, Zongyi Sun, Yibin Wang, Hengbo Wang, Xingtan Zhang, Wei Yao, Yuntong Wang, Xinlong Liu, Maojun Wang, Jianping Wang, Zuhu Deng, Jingsheng Xu, Qinghui Yang, ZhongJian Liu, Baoshan Chen, Muqing Zhang, Ray Ming, Jisen Zhang

Journal: Nat Genet

PubMed ID: 35654976

Doi: 10.1038/s41588-022-01084-1

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Coupled fibromodulin and SOX2 signaling as a critical regulator of metastatic outgrowth in melanoma

Authors: Victor O Oria, Hongyi Zhang, Christopher R Zito, Chetan K Rane, Xian-Yong Ma, Olivia K Provance, Thuy T Tran, Adebowale Adeniran, Yuval Kluger, Mario Sznol, Marcus W Bosenberg, Harriet M Kluger, Lucia B Jilaveanu

Journal: Cell Mol Life Sci

PubMed ID: 35737114

Doi: 10.1007/s00018-022-04364-5

Products & Services: Gene Synthesis

SpyChIP identifies cell type-specific transcription factor occupancy from complex tissues

Authors: Siqian Feng, Richard S Mann

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35696584

Doi: 10.1073/pnas.2122900119

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Regression of EGFR positive established solid tumors in mice with the conditionally active T cell engager TAK-186

Authors: Danielle E Dettling, Eilene Kwok, Lucy Quach, Aakash Datt, Jeremiah D Degenhardt, Anand Panchal, Pui Seto, Jessica L Krakow, Russell Wall, Brian J Hillier, Ying Zhu, Maia Vinogradova, Robert B DuBridge, Chad May

Journal: J Immunother Cancer

PubMed ID: 35728872

Doi: 10.1136/jitc-2021-004336

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular insights into intra-complex signal transmission during stressosome activation

Authors: Algirdas Miksys, Lifei Fu, M Gregor Madej, Duarte N Guerreiro, Susann Kaltwasser, Maria Conway, Sema Ejder, Astrid Bruckmann, Jon Marles-Wright, Richard J Lewis, Conor O'Byrne, Jan Pané-Farré, Christine Ziegler

Journal: Commun Biol

PubMed ID: 35760945

Doi: 10.1038/s42003-022-03549-9

Products & Services: Proteins, Expression, Isolation and Analysis

GLYCINE-RICH RNA-BINDING PROTEIN 7 potentiates effector-triggered immunity through an RNA recognition motif

Authors: Octavina C A Sukarta, Qi Zheng, Erik J Slootweg, Mark Mekken, Melanie Mendel, Vera Putker, André Bertran, Anouk Brand, Hein Overmars, Rikus Pomp, Jan Roosien, Sjef Boeren, Geert Smant, Aska Goverse

Journal: Plant Physiol

PubMed ID: 35218353

Doi: 10.1093/plphys/kiac081

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Heterologous Expression and Characterization of Plant Wax Ester Producing Enzymes

Authors: Daolin Cheng, Ling Li, Ludmila Rizhsky, Priyanka Bhandary, Basil J Nikolau

Journal: Metabolites

PubMed ID: 35888701

Doi: 10.3390/metabo12070577

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Quercetin ameliorates salivary gland apoptosis and inflammation in primary Sjögren's syndrome through regulation of the leptin/OB-R signaling

Authors: Lihua Chang, Aibin Kong, Yun Guo, Jing Zhang, Yue Sun, Penglu Chen, Xiaofei Wang

Journal: Drug Dev Res

PubMed ID: 35749642

Doi: 10.1002/ddr.21964

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Potential of Aspergillus oryzae as a biosynthetic platform for indigoidine, a non-ribosomal peptide pigment with antioxidant activity

Authors: Sarocha Panchanawaporn, Chanikul Chutrakul, Sukanya Jeennor, Jutamas Anantayanon, Nakul Rattanaphan, Kobkul Laoteng

Journal: PLoS ONE

PubMed ID: 35737654

Doi: 10.1371/journal.pone.0270359

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Microstructured Hydrogels to Guide Self-Assembly and Function of Lung Alveolospheres

Authors: Claudia Loebel, Aaron I Weiner, Madeline K Eiken, Jeremy B Katzen, Michael P Morley, Vikram Bala, Fabian L Cardenas-Diaz, Matthew D Davidson, Kazushige Shiraishi, Maria C Basil, Laura T Ferguson, Jason R Spence, Matthias Ochs, Michael F Beers, Edward E Morrisey, Andrew E Vaughan, Jason A Burdick

Journal: Adv Mater

PubMed ID: 35522531

Doi: 10.1002/adma.202202992

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Lineage-specific insertions in T-box riboswitches modulate antibiotic binding and action

Authors: Nikoleta Giarimoglou, Adamantia Kouvela, Ioanna Patsi, Jinwei Zhang, Vassiliki Stamatopoulou, Constantinos Stathopoulos

Journal: Nucleic Acids Res

PubMed ID: 35580054

Doi: 10.1093/nar/gkac359

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Catalytic Properties of Caseinolytic Protease Subunit of and Its Inhibition by a Member of δ-Lactone, Hyptolide

Authors: Cahyo Budiman, Raimalynah Abd Razak, Angelesa Runin Anak Unggit, Rafida Razali, Meiny Suzery, Ruzaidi Azli Mohd Mokhtar, Ping-Chin Lee, Didik Huswo Utomo

Journal: Molecules

PubMed ID: 35744912

Doi: 10.3390/molecules27123787

Products & Services: Proteins, Expression, Isolation and Analysis

The Specificity of ParR Binding Determines the Incompatibility of Conjugative Plasmids in Clostridium perfringens

Authors: Thomas D Watts, Daouda A K Traore, Sarah C Atkinson, Carmen Lao, Natalie Caltabiano, Julian I Rood, Vicki Adams

Journal: MBio

PubMed ID: 35726914

Doi: 10.1128/mbio.01356-22

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Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology

Authors: Giavanna Paterno, Brach M Bell, Kimberly-Marie M Gorion, Stefan Prokop, Benoit I Giasson

Journal: Acta Neuropathol Commun

PubMed ID: 35765058

Doi: 10.1186/s40478-022-01394-9

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A Novel Synthetic Antibody Library with Complementarity-Determining Region Diversities Designed for an Improved Amplification Profile

Authors: Xuelian Bai, Moonseon Jang, Nam Ju Lee, Thi Thu Ha Nguyen, Mooyoung Jung, Jeong Yeon Hwang, Hyunbo Shim

Journal: Int J Mol Sci

PubMed ID: 35682935

Doi: 10.3390/ijms23116255

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Isogenic GAA-KO Murine Muscle Cell Lines Mimicking Severe Pompe Mutations as Preclinical Models for the Screening of Potential Gene Therapy Strategies

Authors: Araceli Aguilar-González, Juan Elías González-Correa, Eliana Barriocanal-Casado, Iris Ramos-Hernández, Miguel A Lerma-Juárez, Sara Greco, Juan José Rodríguez-Sevilla, Francisco Javier Molina-Estévez, Valle Montalvo-Romeral, Giuseppe Ronzitti, Rosario María Sánchez-Martín, Francisco Martín, Pilar Muñoz

Journal: Int J Mol Sci

PubMed ID: 35682977

Doi: 10.3390/ijms23116298

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Characterization of novel antimicrobial peptides designed on the basis of amino acid sequence of peptides from egg white hydrolysate

Authors: Cunkuan Shen, Yunzhi Lin, Tahir Noor Mohammadi, Yoshimitsu Masuda, Ken-Ichi Honjoh, Takahisa Miyamoto

Journal: Int J Food Microbiol

PubMed ID: 35752018

Doi: 10.1016/j.ijfoodmicro.2022.109802

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Novel switchable ECF sigma factor transcription system for improving thaxtomin A production in

Authors: Xuejin Zhao, Weijia Wei, Yeqing Zong, Chaoxian Bai, Xian Guo, Hua Zhu, Chunbo Lou

Journal: Synth Syst Biotechnol

PubMed ID: 35756964

Doi: 10.1016/j.synbio.2022.05.010

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Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans

Authors: Xin-Zi Emily Tang, Shu Xuan Tan, Shawn Hoon, Gene W Yeo

Journal: Nat Med

PubMed ID: 35668177

Doi: 10.1038/s41591-022-01848-6

Products & Services: Recombinant Antibody Expression

Identification of Antigenic Properties of Acinetobacter baumannii Proteins as Novel Putative Vaccine Candidates Using Reverse Vaccinology Approach

Authors: Tohid Piri-Gharaghie, Abbas Doosti, Seyed Abbas Mirzaei

Journal: Appl Biochem Biotechnol

PubMed ID: 35670904

Doi: 10.1007/s12010-022-03995-5

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COVID-19 redux: clinical, virologic, and immunologic evaluation of clinical rebound after nirmatrelvir/ritonavir

Authors: Brian P Epling, Joseph M Rocco, Kristin L Boswell, Elizabeth Laidlaw, Frances Galindo, Anela Kellogg, Sanchita Das, Allison Roder, Elodie Ghedin, Allie Kreitman, Robin L Dewar, Sophie E M Kelly, Heather Kalish, Tauseef Rehman, Jeroen Highbarger, Adam Rupert, Gregory Kocher, Michael R Holbrook, Andrea Lisco, Maura Manion, Richard A Koup, Irini Sereti

Journal: medrxiv

PubMed ID: 35734093

Doi: 10.1101/2022.06.16.22276392

Divergent cis-regulatory evolution underlies the convergent loss of sodium channel expression in electric fish

Authors: Sarah LaPotin, Mary E Swartz, David M Luecke, Savvas J Constantinou, Jason R Gallant, Johann K Eberhart, Harold H Zakon

Journal: Sci Adv

PubMed ID: 35648851

Doi: 10.1126/sciadv.abm2970

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Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling

Authors: Airah Javorsky, Patrick O Humbert, Marc Kvansakul

Journal: Biochem J

PubMed ID: 35670457

Doi: 10.1042/BCJ20220037

Products & Services: Proteins, Expression, Isolation and Analysis

Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR)

Authors: Johannes C van der Mijn, Qiuying Chen, Kristian B Laursen, Francesca Khani, Xiaofei Wang, Princesca Dorsaint, Andrea Sboner, Steven S Gross, David M Nanus, Lorraine J Gudas

Journal: Mol Carcinog

PubMed ID: 35726553

Doi: 10.1002/mc.23437

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Apo-Form Selective Inhibition of IDO for Tumor Immunotherapy

Authors: Wen Liu, Yi Zou, Kaiming Li, Haiqing Zhong, Longbo Yu, Shushan Ge, Yisheng Lai, Xianchi Dong, Qiang Xu, Wenjie Guo

Journal: J Immunol

PubMed ID: 35725271

Doi: 10.4049/jimmunol.2100938

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Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infection

Authors: Amy R Rappaport, Sue-Jean Hong, Ciaran D Scallan, Leonid Gitlin, Arvin Akoopie, Gregory R Boucher, Milana Egorova, J Aaron Espinosa, Mario Fidanza, Melissa A Kachura, Annie Shen, Gloria Sivko, Anne Van Abbema, Robert L Veres, Karin Jooss

Journal: Nat Commun

PubMed ID: 35672369

Doi: 10.1038/s41467-022-31005-z

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Linear DNA amplicons as a novel cancer vaccine strategy

Authors: Antonella Conforti, Erika Salvatori, Lucia Lione, Mirco Compagnone, Eleonora Pinto, Clay Shorrock, James A Hayward, Yuhua Sun, Ben Minghwa Liang, Fabio Palombo, Brian Viscount, Luigi Aurisicchio

Journal: J Exp Clin Cancer Res

PubMed ID: 35668533

Doi: 10.1186/s13046-022-02402-5

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Shelterin Components Modulate Nucleic Acids Condensation and Phase Separation in the Context of Telomeric DNA

Authors: Andrea Soranno, J Jeremías Incicco, Paolo De Bona, Eric J Tomko, Eric A Galburt, Alex S Holehouse, Roberto Galletto

Journal: J Mol Biol

PubMed ID: 35724929

Doi: 10.1016/j.jmb.2022.167685

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A prion-like domain of TFEB mediates the co-aggregation of TFEB and mHTT

Authors: Junsheng Yang, Huilin Xu, Chaoyue Zhang, Xiaotong Yang, Weijie Cai, Xiaoli Chen

Journal: Autophagy

PubMed ID: 35635192

Doi: 10.1080/15548627.2022.2083857

Products & Services: Proteins, Expression, Isolation and Analysis

Asexual Blood-Stage Malaria Vaccine Candidate PfRipr5: Enhanced Production in Insect Cells

Authors: Ricardo Correia, Bárbara Fernandes, Rute Castro, Hikaru Nagaoka, Eizo Takashima, Takafumi Tsuboi, Akihisa Fukushima, Nicola K Viebig, Hilde Depraetere, Paula M Alves, António Roldão

Journal: Front Bioeng Biotechnol

PubMed ID: 35845392

Doi: 10.3389/fbioe.2022.908509

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A cytosolic pentatricopeptide repeat protein is essential for tapetal plastid development by regulating OsGLK1 transcript levels in rice

Authors: Shaoyan Zheng , Jingfang Dong , Jingqin Lu , Jing Li , Dagang Jiang , Haopeng Yu , Simiao Ye , Wenli Bu , Zhenlan Liu , Hai Zhou , Yiliang Ding , Chuxiong Zhuang

Journal: New Phytol .

PubMed ID: 35306663

Doi: 10.1111/nph.18105

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The Texture Change of Chinese Traditional Pig Trotter with Soy Sauce during Stewing Processing: Based on a Thermal Degradation Model of Collagen Fibers

Authors: Yuhai Lin, Ying Wang, Guofeng Jin, Junjie Duan, Yuemei Zhang, Jinxuan Cao

Journal: Foods

PubMed ID: 35741970

Doi: 10.3390/foods11121772

Products & Services: Molecular Biology Reagents

PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal mast cells

Authors: Fan Ye, Yucui Jiang, Yingxin Zong, Jian Zhang, Chan Zhu, Yan Yang, Zongxiang Tang

Journal: Immunol Lett

PubMed ID: 35714789

Doi: 10.1016/j.imlet.2022.06.006

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Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain

Authors: Airah Javorsky, Patrick O Humbert , Marc Kvansakul

Journal: Commun Biol

PubMed ID: 34117354

Doi: 10.1038/s42003-021-02250-7

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LcCCL28-25, Derived from Piscine Chemokine, Exhibits Antimicrobial Activity against Gram-Negative and Gram-Positive Bacteria In Vitro and In Vivo

Authors: Juanjuan Su , Haimeng Li , Jingyang Hu , Danni Wang , Fengchao Zhang , Zheng Fu , Feng Han

Journal: Microbiol Spectr

PubMed ID: 35616397

Doi: 10.1128/spectrum.02515-21

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Umami polypeptide detection system targeting the human T1R1 receptor and its taste-presenting mechanism

Authors: Chuanxi Zhang , Yulu Miao , Yinghui Feng , Jiawei Wang , Zhuoli Tian , Juan Dong , Bei Gao , Lujia Zhang

Journal: Biomaterials

PubMed ID: 35792387

Doi: doi.org/10.1016/j.biomaterials.2022.121660

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Staphylococcal saoABC operon codes for a DNA-binding protein SaoC implicated in the response to nutrient deficit

Authors: Michal Bukowski , Maja Kosecka-Strojek , Anna Madry , Rafal Zagorski-Przybylo , Tomasz Zadlo , Katarzyna Gawron , Benedykt Wladyka

Journal: Int J Mol Sci

PubMed ID: 35742885

Doi: 10.3390/ijms23126443

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3D structure and in situ arrangements of CatSper channel in the sperm flagellum

Authors: Yanhe Zhao , Huafeng Wang , Caroline Wiesehoefer , Naman B Shah , Evan Reetz , Jae Yeon Hwang , Xiaofang Huang , Tse-En Wang , Polina V Lishko , Karen M Davies , Gunther Wennemuth , Daniela Nicastro , Jean-Ju Chung

Journal: Nat Commun

PubMed ID: 35715406

Doi: 10.1038/s41467-022-31050-8

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A Five Year Randomized Controlled Trial to Assess the Efficacy and Antibody Responses to a Commercial and Autogenous Vaccine for the Prevention of Infectious Bovine Keratoconjunctivitis

Authors: Matthew M Hille, Matthew L Spangler, Michael L Clawson, Kelly D Heath, Hiep L X Vu, Rachel E S Rogers, John Dustin Loy

Journal: Vaccines (Basel)

PubMed ID: 35746524

Doi: 10.3390/vaccines10060916

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A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis

Authors: Monir Ejemel, Todd G Smith, Lauren Greenberg, William C Carson, David Lowe, Yong Yang, Felix R Jackson, Clint N Morgan, Brock E Martin, Chantal Kling, Christina L Hutson, Nadia Gallardo-Romero, James A Ellison, Susan Moore, Adam Buzby, John Sullivan-Bolyai, Mark Klempner, Yang Wang

Journal: Sci Rep

PubMed ID: 35672343

Doi: 10.1038/s41598-022-13527-0

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Recombinant chimpanzee adenovirus vector vaccine expressing the spike protein provides effective and lasting protection against SARS-CoV-2 infection in mice

Authors: Mingqing Lu, Kunpeng Liu, Yun Peng, Zhe Ding, Yingwen Li, Alexander Tendu, Xue Hu, Ge Gao, Weiwei Guo, Hang Liu, Juhong Rao, Jiaxuan Zhao, Miaoyu Chen, Zhiming Yuan, Gary Wong, Chao Shan, Yanfeng Yao, Jiaming Lan

Journal: Virol Sin

PubMed ID: 35659605

Doi: 10.1016/j.virs.2022.05.006

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The Role of Dihydroresveratrol in Enhancing the Synergistic Effect of Li01 and Resveratrol in Ameliorating Colitis in Mice

Authors: Yiqiu Fei, Shuobo Zhang, Shengyi Han, Bo Qiu, Yanmeng Lu, Weixing Huang, Fang Li, Deying Chen, Björn Berglund, Hang Xiao, Lanjuan Li, Mingfei Yao

Journal: Research (Wash D C)

PubMed ID: 35935130

Doi: 10.34133/2022/9863845

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Excessive Immune Activation and the Correlation with Decreased Expression of PD-1 at the Maternal-Fetal Interface in Preeclampsia

Authors: Shan Wang, Yining Liu, Yue Liang, Lina Sun, Xiaoxiao Du, Yueyang Shi, Jinlai Meng

Journal: Reprod Sci

PubMed ID: 35708884

Doi: 10.1007/s43032-022-01003-z

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Patulin Detoxification by Recombinant Manganese Peroxidase from Expressed by

Authors: Shuai Wang, Xiaolu Wang, Leena Penttinen, Huiying Luo, Yuhong Zhang, Bo Liu, Bin Yao, Nina Hakulinen, Wei Zhang, Xiaoyun Su

Journal: Toxins (Basel)

PubMed ID: 35878178

Doi: 10.3390/toxins14070440

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Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naïve CD8 T Cell Activation and Expansion by Promoting T Cell-APC Interactions

Authors: Monique M Waldman, Jeremy T Rahkola, Ashton L Sigler, Jeffrey W Chung, Benjamin A S Willett, Ross M Kedl, Rachel S Friedman, Jordan Jacobelli

Journal: Front Immunol

PubMed ID: 35757762

Doi: 10.3389/fimmu.2022.856977

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PD-L1 in gestational trophoblastic disease: an antibody evaluation

Authors: Yvonne M Hoeijmakers, Michiel Simons, Johan Bulten, Mark A J Gorris, Petronella B Ottevanger, I Jolanda M de Vries, Fred C G J Sweep

Journal: Acta Obstet Gynecol Scand

PubMed ID: 35689468

Doi: 10.1111/aogs.14404

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The simultaneous perception of self- and non-self-danger signals potentiates plant innate immunity responses

Authors: Victoria Pastor, Raquel Cervero, Jordi Gamir

Journal: Planta

PubMed ID: 35697869

Doi: 10.1007/s00425-022-03918-y

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Genetic characterization of the cyclohexane carboxylate degradation pathway in the denitrifying bacterium Aromatoleum sp CIB

Authors: David Sanz, Eduardo Díaz

Journal: Environ Microbiol

PubMed ID: 35768954

Doi: 10.1111/1462-2920.16093

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A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis

Authors: Caroline De Souza Pereira, Helenita Costa Quadros, Samuel Yaw Aboagye, Diana Fontinha, Sarah D'Alessandro, Margaret Elizabeth Byrne, Mathieu Gendrot, Isabelle Fonta, Joel Mosnier, Diogo Rodrigo M Moreira, Nicoletta Basilico, David L Williams, Miguel Prudêncio, Bruno Pradines, Maribel Navarro

Journal: Pharmaceutics

PubMed ID: 35745823

Doi: 10.3390/pharmaceutics14061251

Products & Services: Mammalian Expression

Engineering a highly sensitive biosensor for abscisic acid in mammalian cells

Authors: Seo Woo Kim, Kübra Alci, Femke Van Gaever, Yasmine Driege, Keylla Bicalho, Geert Goeminne, Claude Libert, Alain Goossens, Rudi Beyaert, Jens Staal

Journal: FEBS Lett

PubMed ID: 35727199

Doi: 10.1002/1873-3468.14431

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Mapping the deformability of natural and designed cellulosomes in solution

Authors: Jonathan Dorival, Sarah Moraïs, Aurore Labourel, Bartosz Rozycki, Pierre-Andre Cazade, Jérôme Dabin, Eva Setter-Lamed, Itzhak Mizrahi, Damien Thompson, Aurélien Thureau, Edward A Bayer, Mirjam Czjzek

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 35725490

Doi: 10.1186/s13068-022-02165-3

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The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication

Authors: Lucca R Policastro, Isabela Dolci, Andre S Godoy, José V J Silva Júnior, Uriel E A Ruiz, Igor A Santos, Ana C G Jardim, Kirandeep Samby, Jeremy N Burrows, Timothy N C Wells, Laura H V G Gil, Glaucius Oliva, Rafaela S Fernandes

Journal: Viruses

PubMed ID: 35891332

Doi: 10.3390/v14071351

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Gas5 inhibition promotes the axon regeneration in the adult mammalian nervous system

Authors: Xiaoxiao Han, Jiacheng Xu, Zixin Chen, Ping Li, Lili Zhao, Jincheng Tao, Yu Shen, Shengze Zhu, Bin Yu, Jianwei Zhu, Qianqian Cao, Songlin Zhou

Journal: Exp Neurol

PubMed ID: 35779613

Doi: 10.1016/j.expneurol.2022.114157

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ISCA2 deficiency leads to heme synthesis defects and impaired erythroid differentiation in K562 cells by indirect ROS-mediated IRP1 activation

Authors: Jing Wang, Mengyao Jiang, Guanru Yue, Lifei Zhu, Xueqing Wang, Mengxiang Liang, Xiaolin Wu, Beibei Li, Yilin Pang, Guoqiang Tan, Jianghui Li

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 35714932

Doi: 10.1016/j.bbamcr.2022.119307

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Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4

Authors: Hugh C Welles, Hannah A D King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A Schramm, Nicole A Doria-Rose, Adrienne E Swanstrom, James A Hoxie, Celia LaBranche, David C Montefiori, Daniel C Douek, Peter D Kwong, John R Mascola, Mario Roederer, Rosemarie D Mason

Journal: PLoS Pathog

PubMed ID: 35709309

Doi: 10.1371/journal.ppat.1010574

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A DNA vaccine candidate delivered by an electroacupuncture machine provides protective immunity against SARS-CoV-2 infection

Authors: Tsai-Teng Tzeng, Kit Man Chai, Kuan-Yin Shen, Chia-Yi Yu, Shiu-Ju Yang, Wan-Chun Huang, Hung-Chun Liao, Fang-Feng Chiu, Horng-Yunn Dou, Ching-Len Liao, Hsin-Wei Chen, Shih-Jen Liu

Journal: npj Vaccines

PubMed ID: 35662254

Doi: 10.1038/s41541-022-00482-0

Products & Services: Mammalian Expression

Immunoinformatics Design and Assessment of a Multiepitope Antigen (OvMCBL02) for Onchocerciasis Diagnosis and Monitoring

Authors: Bernis Neneyoh Yengo, Cabirou Mounchili Shintouo, An Hotterbeekx, Ntang Emmaculate Yaah, Robert Adamu Shey, Jusal Quanico, Geert Baggerman, Lawrence Ayong, Luc Vanhamme, Rose Njemini, Jacob Souopgui, Robert Colebunders, Stephen Mbigha Ghogomu

Journal: Diagnostics (Basel)

PubMed ID: 35741250

Doi: 10.3390/diagnostics12061440

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Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium

Authors: Aujan Mehregan, Sergio Pérez-Conesa, Yuxuan Zhuang, Ahmad Elbahnsi, Diletta Pasini, Erik Lindahl, Rebecca J Howard, Chris Ulens, Lucie Delemotte

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 35724739

Doi: 10.1016/j.bbamem.2022.183994

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RG2-VLP: a Vaccine Designed to Broadly Protect against Anogenital and Skin Human Papillomaviruses Causing Human Cancer

Authors: Pola Olczak, Ken Matsui, Margaret Wong, Jade Alvarez, Paul Lambert, Neil D Christensen, Jiafen Hu, Bettina Huber, Reinhard Kirnbauer, Joshua W Wang, Richard B S Roden

Journal: J Virol

PubMed ID: 35703545

Doi: 10.1128/jvi.00566-22

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Snake Venom Hydrogels as a Rapid Hemostatic Agent for Uncontrolled Bleeding

Authors: Ramanathan Yegappan, Jan Lauko, Zhao Wang, Martin F Lavin, Amanda W Kijas, Alan E Rowan

Journal: Adv Healthc Mater

PubMed ID: 35652565

Doi: 10.1002/adhm.202200574

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Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms

Authors: Jia Li, Tingting Hong, Yue Wei, Lei Guo, Minjung Lee, Hui Yang, Caleb Class, Yaling Yang, Xiaoqiong Wang, Hua He, Stefan Siwko, M James You, Yubin Zhou, Guillermo Garcia-Manero, Yun Huang

Journal: Clin Epigenetics

PubMed ID: 35765052

Doi: 10.1186/s13148-022-01297-5

Products & Services: Proteins, Expression, Isolation and Analysis

Metabolic sensor O-GlcNAcylation regulates erythroid differentiation and globin production via BCL11A

Authors: Sudjit Luanpitpong, Xing Kang, Montira Janan, Kanjana Thumanu, Jingting Li, Pakpoom Kheolamai, Surapol Issaragrisil

Journal: Stem Cell Res Ther

PubMed ID: 35739577

Doi: 10.1186/s13287-022-02954-5

Products & Services: Plasmid DNA Preparation

The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression

Authors: Jianchao Zhang, Xiaokai Fan, Yunfan Zhou, Liang Chen, Hai Rao