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Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents

Authors: Jiyun Zhu, Linfeng Li, Aleksandra Drelich, Bala C Chenna, Drake M Mellott, Zane W Taylor, Vivian Tat, Christopher Z Garcia, Ardala Katzfuss, Chien-Te K Tseng, Thomas D Meek

Journal: Front Chem

PubMed ID: 35860632

Doi: 10.3389/fchem.2022.867928

Products & Services: Gene Synthesis

HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations

Authors: Yong Du, Yongfeng Chen, Yuxia Wang, Jinju Chen, Xiaorong Lu, Li Zhang, Yan Li, Zhaofu Wang, Guozhong Ye, George Zhang

Journal: Mol Cancer Ther

PubMed ID: 35499406

Doi: 10.1158/1535-7163.MCT-21-0835

Products & Services: Proteins, Expression, Isolation and Analysis

Ligand-induced transmembrane conformational coupling in monomeric EGFR

Authors: Shwetha Srinivasan, Raju Regmi, Xingcheng Lin, Courtney A Dreyer, Xuyan Chen, Steven D Quinn, Wei He, Matthew A Coleman, Kermit L Carraway, Bin Zhang, Gabriela S Schlau-Cohen

Journal: Nat Commun

PubMed ID: 35794108

Doi: 10.1038/s41467-022-31299-z

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Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis

Authors: Wenli Liu, Nataliya Östberg, Mustafa Yalcinkaya, Huijuan Dou, Kaori Endo-Umeda, Yang Tang, Xintong Hou, Tong Xiao, Trevor P Fidler, Sandra Abramowicz, Yong-Guang Yang, Oliver Soehnlein, Alan R Tall, Nan Wang

Journal: J Clin Invest

PubMed ID: 35587375

Doi: 10.1172/JCI155724

Products & Services: Recombinant Proteins

Construction of a Novel Clinical Stage-Related Gene Signature for Predicting Outcome and Immune Response in Hepatocellular Carcinoma

Authors: Liu Yang, Long-Fei Zeng, Guo-Qing Hong, Qing Luo, Xing Lai

Journal: J Immunol Res

PubMed ID: 35865652

Doi: 10.1155/2022/6535009

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Apela gene therapy alleviates pulmonary hypertension in rats

Authors: Yuexin Hu, Liangli Jin, Yang Pan, Jue Zou, Zhi Wang

Journal: FASEB J

PubMed ID: 35747913

Doi: 10.1096/fj.202200266R

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Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Authors: Gamma Chi , Qiansheng Liang , Akshay Sridhar , John B Cowgill , Kasim Sader , Mazdak Radjainia , Pu Qian , Pablo Castro-Hartmann , Shayla Venkaya , Nanki Kaur Singh , Gavin McKinley , Alejandra Fernandez-Cid , Shubhashish M M Mukhopadhyay , Nicola A Burgess-Brown , Lucie Delemotte , Manuel Covarrubias , Katharina L Dürr

Journal: Nat Commun

PubMed ID: 35840580

Doi: 10.1038/s41467-022-29594-w

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Induction of Broadly Cross-Reactive Antibody Responses to SARS-CoV-2 Variants by S1 Nanoparticle Vaccines

Authors: Cong Sun , Run-Yu Yuan , Chu Xie , Jiu-Feng Sun , Xin-Yan Fang , Yi-Sha Hu , Xiao-Hui Yu, Zheng Liu , Mu-Sheng Zeng , Yin-Feng Kang

Journal: J Virol

PubMed ID: 35699445

Doi: 10.1128/jvi.00383-22

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A precise and efficient adenine base editor

Authors: Tianxiang Tu , Zongming Song , Xiaoyu Liu , Shengxing Wang , Xiaoxue He , Haitao Xi , Jiahua Wang , Tong Yan , Haoran Chen , Zhenwu Zhang , Xiujuan Lv , Jineng Lv , Xiu-Feng Huang , Junzhao Zhao , Chao-Po Lin , Caixia Gao , Jinwei Zhang , Feng Gu

Journal: Mol Ther

PubMed ID: 35821638

Doi: 10.1016/j.ymthe.2022.07.010

Products & Services: Gene Synthesis

Native Glucagon Amyloids Catalyze Key Metabolic Reactions

Authors: Elad Arad , Gal Yosefi , Sofiya Kolusheva , Ronit Bitton , Hanna Rapaport , Raz Jelinek

Journal: ACS Nano

PubMed ID: 35866668

Doi: 10.1021/acsnano.2c05166

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Rational development of a combined mRNA vaccine against COVID-19 and influenza

Authors: Qing Ye , Mei Wu , Chao Zhou , Xishan Lu , Baoying Huang , Ning Zhang , Hui Zhao , Hang Chi , Xiaojing Zhang , Dandan Ling , Rong-Rong Zhang , Zhuofan Li , Dan Luo , Yi-Jiao Huang , Hong-Ying Qiu , Haifeng Song , Wenjie Tan , Ke Xu , Bo Ying , Cheng-Feng Qin

Journal: npj Vaccines

PubMed ID: 35882870

Doi: 10.1038/s41541-022-00478-w

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Detection of Nipah and Hendra Viruses Using Recombinant Human Ephrin B2 Capture Virus in Immunoassays

Authors: Ming Yang , Wenjun Zhu , Thang Truong , Bradley Pickering , Shawn Babiuk , Darwyn Kobasa , Logan Banadyga

Journal: Viruses

PubMed ID: 36016279

Doi: 10.3390/v14081657

Products & Services: Proteins, Expression, Isolation and Analysis

Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults

Authors: Hassen Kared, Asia-Sophia Wolf, Amin Alirezaylavasani, Anthony Ravussin, Guri Solum, Trung The Tran, Fridtjof Lund-Johansen, John Torgils Vaage, Lise Sofie Nissen-Meyer, Unni C Nygaard, Olav Hungnes, Anna H Robertson, Lisbeth Meyer Næss, Lill Trogstad, Per Magnus, Ludvig A Munthe, Siri Mjaaland

Journal: Nat Commun

PubMed ID: 35851055

Doi: 10.1038/s41467-022-31888-y

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Comprehensive Evaluation and Comparison of Machine Learning Methods in QSAR Modeling of Antioxidant Tripeptides

Authors: Zhenjiao Du, Donghai Wang, Yonghui Li

Journal: ACS Omega

PubMed ID: 35910147

Doi: 10.1021/acsomega.2c03062

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Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis

Authors: Zachary Armstrong, Richard W Meek, Liang Wu, James N Blaza, Gideon J Davies

Journal: Structure

PubMed ID: 35907402

Doi: 10.1016/j.str.2022.07.001

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Structural, functional, and immunogenicity implications of F9 gene recoding

Authors: Upendra K Katneni, Aikaterini Alexaki, Ryan C Hunt, Nobuko Hamasaki-Katagiri, Gaya K Hettiarachchi, Jacob M Kames, Joseph R McGill, David D Holcomb, John C Athey, Brian Lin, Leonid A Parunov, Tal Kafri, Qi Lu, Robert Peters, Mikhail V Ovanesov, Darón I Freedberg, Haim Bar, Anton A Komar, Zuben E Sauna, Chava Kimchi-Sarfaty

Journal: Blood Adv

PubMed ID: 35413099

Doi: 10.1182/bloodadvances.2022007094

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Programmable CRISPR-Cas9 microneedle patch for long-term capture and real-time monitoring of universal cell-free DNA

Authors: Bin Yang, Jilie Kong, Xueen Fang

Journal: Nat Commun

PubMed ID: 35810160

Doi: 10.1038/s41467-022-31740-3

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Silencing the enhancer of zeste homologue 2, E, represses axon regeneration of dorsal root ganglion neuronszh 2

Authors: Ting-Ting Guo, Ying Zhao, Wei-Xiao Huang, Tao Zhang, Li-Li Zhao, Xiao-Song Gu, Song-Lin Zhou

Journal: Neural Regen Res

PubMed ID: 34916437

Doi: 10.4103/1673-5374.330623

Products & Services: Gene Synthesis

Genetically Encoded Aryl Alkyne for Raman Spectral Imaging of Intracellular α-Synuclein Fibrils

Authors: Matthew D Watson, Jennifer C Lee

Journal: J Mol Biol

PubMed ID: 35792158

Doi: 10.1016/j.jmb.2022.167716

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A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry

Authors: Liangqin Tong, Lin Wang, Shumin Liao, Xiaoping Xiao, Jing Qu, Chunli Wu, Yibin Zhu, Wanbo Tai, Yanhong Huang, Penghua Wang, Liang Li, Renli Zhang, Ye Xiang, Gong Cheng

Journal: MBio

PubMed ID: 35862773

Doi: 10.1128/mbio.01485-22

Products & Services: Proteins, Expression, Isolation and Analysis

Stitchr: stitching coding TCR nucleotide sequences from V/J/CDR3 information

Authors: James M Heather, Matthew J Spindler, Marta Herrero Alonso, Yifang Ivana Shui, David G Millar, David S Johnson, Mark Cobbold, Aaron N Hata

Journal: Nucleic Acids Res

PubMed ID: 35325179

Doi: 10.1093/nar/gkac190

Products & Services: Proteins, Expression, Isolation and Analysis

Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

Authors: Jorge Franco, Francesco Piacente, Melanie Walter, Simone Fratta, Moustafa Ghanem, Andrea Benzi, Irene Caffa, Alexander V Kurkin, Andrea Altieri, Patrick Herr, Macarena Martínez-Bailén, Inmaculada Robina, Santina Bruzzone, Alessio Nencioni, Alberto Del Rio

Journal: Pharmaceuticals (Basel)

PubMed ID: 35890155

Doi: 10.3390/ph15070855

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Mycoplasma hyopneumoniae membrane protein Mhp271 interacts with host UPR protein GRP78 to facilitate infection

Authors: Qiao Pan, Qingyuan Xu, Tong Liu, Yujuan Zhang, Jiuqing Xin

Journal: Mol Microbiol

PubMed ID: 35791781

Doi: 10.1111/mmi.14963

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Optimization of Potent and Specific Trypanothione Reductase Inhibitors: A Structure-Based Drug Discovery Approach

Authors: Theo Battista, Stefano Federico, Simone Brogi, Luca Pozzetti, Tuhina Khan, Stefania Butini, Anna Ramunno, Eleonora Fiorentino, Stefania Orsini, Trentina Di Muccio, Annarita Fiorillo, Cécile Exertier, Daniel Di Risola, Gianni Colotti, Sandra Gemma, Andrea Ilari, Giuseppe Campiani

Journal: ACS Infect Dis

PubMed ID: 35880849

Doi: 10.1021/acsinfecdis.2c00325

Products & Services: PCR Cloning and Subcloning

Grp94 Works Upstream of BiP in Protein Remodeling Under Heat Stress

Authors: Yaa S Amankwah, Preston Collins, Yasmeen Fleifil, Erin Unruh, Kevin J Ruiz Márquez, Katherine Vitou, Andrea N Kravats

Journal: J Mol Biol

PubMed ID: 35905823

Doi: 10.1016/j.jmb.2022.167762

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Proteomic and Phosphoproteomic Analyses Reveal Gibel Carp Responses to Cyprinid Herpesvirus 2 Infection

Authors: Chen Xu, Yiqun Li, Zidong Xiao, Jie Yang, Mingyang Xue, Nan Jiang, Yan Meng, Wenzhi Liu, Yuding Fan, Yong Zhou

Journal: J Proteome Res

PubMed ID: 35792615

Doi: 10.1021/acs.jproteome.2c00253

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[C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease

Authors: Tharick A Pascoal, Mira Chamoun, Elad Lax, Hsiao-Ying Wey, Monica Shin, Kok Pin Ng, Min Su Kang, Sulantha Mathotaarachchi, Andrea L Benedet, Joseph Therriault, Firoza Z Lussier, Frederick A Schroeder, Jonathan M DuBois, Baileigh G Hightower, Tonya M Gilbert, Nicole R Zürcher, Changning Wang, Robert Hopewell, Mallar Chakravarty, Melissa Savard, Emilie Thomas, Sara Mohaddes, Sarah Farzin, Alyssa Salaciak, Stephanie Tullo, A Claudio Cuello, Jean-Paul Soucy, Gassan Massarweh, Heungsun Hwang, Eliane Kobayashi, Bradley T Hyman, Bradford C Dickerson, Marie-Christine Guiot, Moshe Szyf, Serge Gauthier, Jacob M Hooker, Pedro Rosa-Neto

Journal: Nat Commun

PubMed ID: 35853847

Doi: 10.1038/s41467-022-30653-5

Products & Services: Proteins, Expression, Isolation and Analysis

Genome-wide CRISPR Screening Reveals Pyrimidine Metabolic Reprogramming in 5-FU Chronochemotherapy of Colorectal Cancer

Authors: Ya Niu, Xinyi Fan, Yaping Wang, Jiaxin Lin, Luchun Hua, Xiaobo Li, Ruizhe Qian, Chao Lu

Journal: Front Oncol

PubMed ID: 35903686

Doi: 10.3389/fonc.2022.949715

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Oral Administration with Recombinant Attenuated Regulated Delayed Lysis Vaccines Protecting against Kidney Abscess Formation

Authors: Yanchen Liang, Haochi Zhang, Na Pan, Yang Liu, Shouxin Sheng, Haotian Li, Xuemei Bao, Xiao Wang

Journal: Vaccines (Basel)

PubMed ID: 35891237

Doi: 10.3390/vaccines10071073

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A time-resolved, multi-symbol molecular recorder via sequential genome editing

Authors: Junhong Choi, Wei Chen, Anna Minkina, Florence M Chardon, Chase C Suiter, Samuel G Regalado, Silvia Domcke, Nobuhiko Hamazaki, Choli Lee, Beth Martin, Riza M Daza, Jay Shendure

Journal: Nature

PubMed ID: 35794474

Doi: 10.1038/s41586-022-04922-8

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Overexpression of the scopoletin biosynthetic pathway enhances lignocellulosic biomass processing

Authors: Lennart Hoengenaert, Marlies Wouters, Hoon Kim, Barbara De Meester, Kris Morreel, Steven Vandersyppe, Jacob Pollier, Sandrien Desmet, Geert Goeminne, John Ralph, Wout Boerjan, Ruben Vanholme

Journal: Sci Adv

PubMed ID: 35857515

Doi: 10.1126/sciadv.abo5738

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Pharmacokinetic Characteristics, Safety, and Tolerability of Telitacicept, an Injectable Recombinant Human B-Lymphocyte Stimulating Factor Receptor-Antibody Fusion Protein, in Healthy Chinese Subjects

Authors: Jing Xie, Xiaoyun Fan, Yue Su, Huan Zhou, Shugang Cao, Xingyu Zhu, Minhui Zhu, Cuixia He, Ying Wang, Ling Fan, Qin Ge, Juan Zhu, Bingyan Liu, Xiao Chen, Yunqiu Xie, Ling Ma, Yuanyuan Liu, Juan Chen, Huaxue Wang, Zhijun Li

Journal: Clin Pharmacol Drug Dev

PubMed ID: 35844038

Doi: 10.1002/cpdd.1136

Products & Services: Mammalian Expression

A biepitope, adjuvant-free, self-assembled influenza nanovaccine provides cross-protection against H3N2 and H1N1 viruses in mice

Authors: Yongbo Qiao, YaXin Zhang, Jie Chen, Shenghui Jin, Yaming Shan

Journal: Nano Res

PubMed ID: 35911479

Doi: 10.1007/s12274-022-4482-4

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Protective Human Anti-Poxvirus Monoclonal Antibodies Are Generated from Rare Memory B Cells Isolated by Multicolor Antigen Tetramers

Authors: Xiuling Gu, Yufan Zhang, Wei Jiang, Dongfang Wang, Jiao Lu, Guanglei Gu, Chengfeng Qin, Min Fang

Journal: Vaccines (Basel)

PubMed ID: 35891248

Doi: 10.3390/vaccines10071084

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A hydrogel platform for co-delivery of immunomodulatory proteins for pancreatic islet allografts

Authors: Juan D Medina, Graham F Barber, Maria M Coronel, Michael D Hunckler, Stephen W Linderman, Michelle J Quizon, Vahap Ulker, Esma S Yolcu, Haval Shirwan, Andrés J García

Journal: J Biomed Mater Res A

PubMed ID: 35841329

Doi: 10.1002/jbm.a.37429

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Neoantigen Identification and Response to Adoptive Cell Transfer in Anti-PD-1 Naïve and Experienced Patients with Metastatic Melanoma

Authors: Shoshana T Levi, Amy R Copeland, Shirley Nah, Jessica S Crystal, Gabriel D Ivey, Almin Lalani, Mohammad Jafferji, Bradley S White, Neilesh B Parikh, Vid Leko, Sri Krishna, Frank Lowery, Todd D Prickett, Jared J Gartner, Li Jia, Yong F Li, Abraham Sachs, Sivasish Sindiri, Welles Robinson, Billel Gasmi, James C Yang, Stephanie L Goff, Steven A Rosenberg, Paul F Robbins

Journal: Clin Cancer Res

PubMed ID: 35247926

Doi: 10.1158/1078-0432.CCR-21-4499

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Non-synergy of PD-1 blockade with T-cell therapy in solid tumors

Authors: John S Davies, Farrah Karimipour, Ling Zhang, Nisha Nagarsheth, Scott Norberg, Carylinda Serna, Julius Strauss, Shinheng Chiou, James L Gulley, Christian S Hinrichs

Journal: J Immunother Cancer

PubMed ID: 35793866

Doi: 10.1136/jitc-2022-004906

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An effective strategy for the humanization of antibody fragments under an accelerated timeline

Authors: Isabella Gizzi Jiacomini, Martina Beltramino, Fanny Boursin, João Carlos Minozzo, Juliana Ferreira de Moura, Philippe Billiald, Larissa Magalhães Alvarenga, Nicolas Aubrey

Journal: Int J Biol Macromol

PubMed ID: 35803408

Doi: 10.1016/j.ijbiomac.2022.06.195

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A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir

Authors: Subramanyam Vankadara, Monique Danielle Dawson, Jia Yi Fong, Qin Yao Oh, Qi An Ang, Boping Liu, Hong Yun Chang, Judice Koh, Xiaoying Koh, Qian Wen Tan, Joma Joy, Cheng San Brian Chia

Journal: ACS Med Chem Lett

PubMed ID: 35971455

Doi: 10.1021/acsmedchemlett.2c00260

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Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions

Authors: Mengying Liu, Liane Z X Huang, Anthony A Smits, Christian Büll, Yoshiki Narimatsu, Frank J M van Kuppeveld, Henrik Clausen, Cornelis A M de Haan, Erik de Vries

Journal: Nat Commun

PubMed ID: 35831293

Doi: 10.1038/s41467-022-31840-0

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Preclinical immunogenicity and efficacy of a candidate COVID-19 vaccine based on a vesicular stomatitis virus-SARS-CoV-2 chimera

Authors: Amy S Espeseth, Maoli Yuan, Michael Citron, Lucia Reiserova, Gavin Morrow, Aaron Wilson, Melanie Horton, Mark Rukhman, Keith Kinek, Fuxiang Hou, Shui L Li, Fengsheng Li, Yesle Choi, Gwen Heidecker, Bin Luo, Guoxin Wu, Lan Zhang, Erica Strable, Joanne DeStefano, Susan Secore, Tarit K Mukhopadhyay, Douglas D Richardson, Eddy Sayeed, Lisa S Welch, Andrew J Bett, Mark B Feinberg, Swati B Gupta, Christopher L Cooper, Christopher L Parks

Journal: EBioMedicine

PubMed ID: 35915046

Doi: 10.1016/j.ebiom.2022.104203

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CAR T-Cell Targeting of Macrophage Colony-Stimulating Factor Receptor

Authors: Daniela Yordanova Achkova, Richard Esmond Beatson, John Maher

Journal: Cells

PubMed ID: 35883636

Doi: 10.3390/cells11142190

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N-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs

Authors: Tien-Hao Chen, Vladimir Potapov, Nan Dai, Jennifer L Ong, Bijoyita Roy

Journal: Sci Rep

PubMed ID: 35906281

Doi: 10.1038/s41598-022-17249-1

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Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy

Authors: Christianne Groeneveldt, Priscilla Kinderman, Jordi J C van Stigt Thans, Camilla Labrie, Lisa Griffioen, Marjolein Sluijter, Diana J M van den Wollenberg, Rob C Hoeben, Joke M M den Haan, Sjoerd H van der Burg, Thorbald van Hall, Nadine van Montfoort

Journal: J Immunother Cancer

PubMed ID: 35853671

Doi: 10.1136/jitc-2021-004464

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Design of two immunotoxins based rovalpituzumab antibody against DLL3 receptor; a promising potential opportunity

Authors: Mohammad Hossein Ataee, Seyed Ali Mirhosseini, Reza Mirnejad, Ehsan Rezaie, Hamideh Mahmoodzadeh Hosseini, Jafar Amani

Journal: Res Pharm Sci

PubMed ID: 36034078

Doi: 10.4103/1735-5362.350243

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Comparison of the immunogenicity of five COVID-19 vaccines in Sri Lanka

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Saubhagya Danasekara, Laksiri Gomes, Suranga Fernando, Dinuka Guruge, Thushali Ranasinghe, Banuri Gunasekera, Achala Kamaladasa, Heshan Kuruppu, Gayasha Somathilake, Jeewantha Jayamali, Deshni Jayathilaka, Helanka Dinesh Kumara Wijayatilake, Pradeep Darshana Pushpakumara, Michael Harvie, Thashmi Nimasha, Shiromi Devika Grace de Silva, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Jack Tan, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: Immunology

PubMed ID: 35751563

Doi: 10.1111/imm.13535

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Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins

Authors: David Moi, Shunsuke Nishio, Xiaohui Li, Clari Valansi, Mauricio Langleib, Nicolas G Brukman, Kateryna Flyak, Christophe Dessimoz, Daniele de Sanctis, Kathryn Tunyasuvunakool, John Jumper, Martin Graña, Héctor Romero, Pablo S Aguilar, Luca Jovine, Benjamin Podbilewicz

Journal: Nat Commun

PubMed ID: 35794124

Doi: 10.1038/s41467-022-31564-1

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A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes

Authors: Khyati Girdhar, Qian Huang, I-Ting Chow, Tommi Vatanen, Claudia Brady, Amol Raisingani, Patrick Autissier, Mark A Atkinson, William W Kwok, C Ronald Kahn, Emrah Altindis

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35878027

Doi: 10.1073/pnas.2120028119

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Anti-Ischemic Effects of PIK3IP1 Are Mediated through Its Interactions with the ET-PI3Kγ-AKT Axis

Authors: Jei Hyoung Park, Kyoung Jin Nho, Ji Young Lee, Yung Joon Yoo, Woo Jin Park, Chunghee Cho, Do Han Kim

Journal: Cells

PubMed ID: 35883611

Doi: 10.3390/cells11142162

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Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission

Authors: Sash Lopaticki, Robyn McConville, Alan John, Niall Geoghegan, Shihab Deen Mohamed, Lisa Verzier, Ryan W J Steel, Cindy Evelyn, Matthew T O'Neill, Niccolay Madiedo Soler, Nichollas E Scott, Kelly L Rogers, Ethan D Goddard-Borger, Justin A Boddey

Journal: Nat Commun

PubMed ID: 35906227

Doi: 10.1038/s41467-022-32076-8

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gC1qR/C1qBP/HABP-1: Structural Analysis of the Trimeric Core Region, Interactions With a Novel Panel of Monoclonal Antibodies, and Their Influence on Binding to FXII

Authors: Ying Zhang, Alexander J Vontz, Ethan M Kallenberger, Xin Xu, Nicoleta T Ploscariu, Kasra X Ramyar, Brandon L Garcia, Berhane Ghebrehiwet, Brian V Geisbrecht

Journal: Front Immunol

PubMed ID: 35865516

Doi: 10.3389/fimmu.2022.887742

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Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected Individuals

Authors: Zehra Karakoese, Mara Schwerdtfeger, Christina B Karsten, Stefan Esser, Ulf Dittmer, Kathrin Sutter

Journal: Front Immunol

PubMed ID: 35911692

Doi: 10.3389/fimmu.2022.936918

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Orphan nuclear receptor NUR77 relieves insulin resistance in HTR-8/SVneo trophoblast cells through activation of autophagy and insulin signaling

Authors: Ling Li, Yu Bai, Runyu Du, Lei Tang, Ling Li

Journal: J Physiol Biochem

PubMed ID: 35902547

Doi: 10.1007/s13105-022-00901-9

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Transcriptional response to VZV infection is modulated by RNA polymerase III in lung epithelial cell lines

Authors: Brianna M Doratt, Elizabeth Vance, Delphine C Malherbe, Mark T W Ebbert, Ilhem Messaoudi

Journal: Front Cell Infect Microbiol

PubMed ID: 35959363

Doi: 10.3389/fcimb.2022.943587

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Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter

Authors: Deepthi Joseph, Smruti Ranjan Nayak, Aravind Penmatsa

Journal: EMBO J

PubMed ID: 35796008

Doi: 10.15252/embj.2022110735

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SARS-CoV-2 Delta spike protein enhances the viral fusogenicity and inflammatory cytokine production

Authors: Zhujun Ao, Maggie Jing Ouyang, Titus Abiola Olukitibi, Xiaojian Yao

Journal: iScience

PubMed ID: 35854977

Doi: 10.1016/j.isci.2022.104759

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Inactive and active state structures template selective tools for the human 5-HT receptor

Authors: Shicheng Zhang, He Chen, Chengwei Zhang, Ying Yang, Petr Popov, Jing Liu, Brian E Krumm, Can Cao, Kuglae Kim, Yan Xiong, Vsevolod Katritch, Brian K Shoichet, Jian Jin, Jonathan F Fay, Bryan L Roth

Journal: Nat Struct Mol Biol

PubMed ID: 35835867

Doi: 10.1038/s41594-022-00796-6

Products & Services: Proteins, Expression, Isolation and Analysis

A recombinant VSV-vectored vaccine rapidly protects nonhuman primates against heterologous lethal Lassa fever

Authors: Robert W Cross, Courtney Woolsey, Abhishek N Prasad, Viktoriya Borisevich, Krystle N Agans, Daniel J Deer, Joan B Geisbert, Natalie S Dobias, Karla A Fenton, Thomas W Geisbert

Journal: Cell Rep

PubMed ID: 35858566

Doi: 10.1016/j.celrep.2022.111094

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Low molecular weight fucoidan alleviates cerebrovascular damage by promoting angiogenesis in type 2 diabetes mice

Authors: Zhi Li, Ning Wu, Jing Wang, Yang Yue, Lihua Geng, Quanbin Zhang

Journal: Int J Biol Macromol

PubMed ID: 35841956

Doi: doi.org/10.1016/j.ijbiomac.2022.07.053

Products & Services: Proteins, Expression, Isolation and Analysis

Structural insight into apelin receptor-G protein stoichiometry

Authors: Yang Yue , Lier Liu , Li-Jie Wu , Yiran Wu , Ling Wang , Fei Li , Junlin Liu , Gye-Won Han , Bo Chen , Xi Lin , Rebecca L Brouillette , Émile Breault , Jean-Michel Longpré , Songting Shi , Hui Lei , Philippe Sarret , Raymond C Stevens , Michael A Hanson , Fei Xu

Journal: Nat Struct Mol Biol

PubMed ID: 35817871

Doi: 10.1038/s41594-022-00797-5

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Endothelial PHD2 deficiency induces nitrative stress suppression of caveolin-1 in pulmonary hypertension

Authors: Bin Liu, Yi Peng, Dan Yi, Narsa Machireddy, Daoyin Dong, Karina Ramirez, Jingbo Dai, Rebecca Vanderpool, Maggie M Zhu, Zhiyu Dai, You-Yang Zhao

Journal: Eur Respir J

PubMed ID: 35798360

Doi: 10.1183/13993003.02643-2021

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Purification, characterization, and preliminary serial crystallography diffraction advances structure determination of full-length human particulate guanylyl cyclase A receptor

Authors: Shangji Zhang, Debra T Hansen, Jose M Martin-Garcia, James D Zook, Shuchong Pan, Felicia M Craciunescu, John C Burnett, Petra Fromme

Journal: Sci Rep

PubMed ID: 35821229

Doi: 10.1038/s41598-022-15798-z

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Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes.

Authors: Uxue Ballesteros , Asier Etxaniz , Marina N Iriondo , Yaiza R Varela , Melisa Lázaro , Ana R Viguera , L Ruth Montes , Mikel Valle , Félix M Goñi , Alicia Alonso

Journal: Int J Biol Macromol

PubMed ID: 35618088

Doi: 10.1016/j.ijbiomac.2022.05.129.

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Heterologous mRNA vaccine booster increases neutralization of SARS-CoV-2 Omicron BA.2 variant

Authors: Gen Li , Zhongcheng Zhou , Peng Du , Meixiao Zhan , Ning Li 1、, Xinxin Xiong , Shengjun Tang , Miao Man, Daniel T Baptista-Hon, Ligong Lu

Journal: Signal Transduct Target Ther

PubMed ID: 35853864

Doi: 10.1038/s41392-022-01062-3.

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Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions

Authors: Xingxing Li , Liuqing He , Jianhua Luo , Yangling Zheng , Yao Zhou , Danyang Li , Yuanyuan Zhang , Zhenrui Pan , Yanyan Li , Liang Tao

Journal: Nat Commun

PubMed ID: 35882856

Doi: 10.1038/s41467-022-31994-x

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Effective Functional Immunogenicity of a DNA Vaccine Combination Delivered via In Vivo Electroporation Targeting Malaria Infection and Transmission

Authors: Yi Cao , Clifford T H Hayashi , Fidel Zavala , Abhai K Tripathi , Hayk Simonyan , Colin N Young , Leor C Clark , Yukari Usuda , Jacob M Van Parys , Nirbhay Kumar

Journal: Vaccines (Basel)

PubMed ID: 35891298

Doi: 10.3390/vaccines10071134

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One-pot isothermal LAMP-CRISPR-based assay for Klebsiella pneumoniae detection

Authors: Xiaotong Qiu , Xueping Liu , Xiao Ma , Ruixue Wang , Shenglin Chen , Fang Li , Zhenjun Li

Journal: Microbiol Spectr

PubMed ID: 35856669

Doi: 10.1128/spectrum.01545-22

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Direct adenylation from 5?-OH-terminated oligonucleotides by a fusion enzyme containing Pfu RNA ligase and T4 polynucleotide kinase

Authors: Zhengquan Yang , Chengliang Zhang , Guojun Lian , Shijie Dong , Menghui Song , Hengrong Shao , Jingmei Wang , Tao Zhong , Zhenni Luo , Shengnan Jin , Chunming Ding

Journal: Nucleic Acids Res

PubMed ID: 35819229

Doi: org/10.1093/nar/gkac604

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Structural insights into the activation of neurokinin 2 receptor by neurokinin A

Authors: Wenjing Sun , Qingning Yuan , Huanhuan Zhang , Fan Yang , Shenglong Ling , Yifan Luo , Pei Lv , H Eric Xu , Changlin Tian , Wanchao Yin , Pan Shi

Journal: Cell Discov

PubMed ID: 35882833

Doi: 10.1038/s41421-022-00437-8

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Discrimination between Different DNA Lesions by Monitoring Single-Molecule Polymerase Stalling Kinetics during Nanopore Sequencing

Authors: Jinyue Zhang , Yu Wang , Yuqin Wang , Panke Zhang , Hong-Yuan Chen , Shuo Huang

Journal: Nano Lett

PubMed ID: 35713465

Doi: 10.1021/acs.nanolett.2c01833

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Generation of a Soluble African Horse Sickness Virus VP7 Protein Capable of Forming Core-like Particles

Authors: Shani Bekker, Henk Huismans, Vida van Staden

Journal: Viruses

PubMed ID: 35893692

Doi: 10.3390/v14081624

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Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance

Authors: Xinlei Zhuang, Zhe Wang, Jiansheng Fan, Xuefei Bai, Yingchun Xu, James J Chou, Tingjun Hou, Shuqing Chen, Liqiang Pan

Journal: Nat Commun

PubMed ID: 35907884

Doi: 10.1038/s41467-022-32159-6

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Effects of SPA4 peptide on lipopolysaccharide-disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury

Authors: Asif Alam Chowdhury, Nachiket M Godbole, Neha Chataut, Stanley Kosanke, Karla Rodgers, Shanjana Awasthi

Journal: Physiol Rep

PubMed ID: 35838161

Doi: 10.14814/phy2.15353

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Humanin derivative, HNG, enhances neurotransmitter release

Authors: Natsumi Ikegawa, Ayari Kozuka, Nozomi Morita, Minetaka Murakami, Nobuyuki Sasakawa, Takako Niikura

Journal: Biochim Biophys Acta Gen Subj

PubMed ID: 35843407

Doi: 10.1016/j.bbagen.2022.130204

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Development of a Multi-Epitope Vaccine for and Evaluation of Its Immune Responses in Mice and Piglets

Authors: Gaojian Li, Jinqi Shu, Jing Jin, Jianhong Shu, Huapeng Feng, Jian Chen, Yulong He

Journal: Int J Mol Sci

PubMed ID: 35887246

Doi: 10.3390/ijms23147899

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BioWF: A Naturally-Fused, Di-Domain Biocatalyst from Biotin Biosynthesis Displays an Unexpectedly Broad Substrate Scope

Authors: Shona M Richardson, Peter J Harrison, Michael A Herrera, Menglu Wang, Rebecca Verez, Gustavo Perez Ortiz, Dominic J Campopiano

Journal: Chembiochem

PubMed ID: 35695820

Doi: 10.1002/cbic.202200171

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A cell-free paper-based biosensor dependent on allosteric transcription factors (aTFs) for on-site detection of harmful metals Hg and Pb in water

Authors: Yongkang Zhang, Chen Zhao, Huaixiu Bi, Xi Zhang, Bin Xue, Chenyu Li, Shang Wang, Xiaobo Yang, Zhigang Qiu, Jingfeng Wang, Zhiqiang Shen

Journal: J Hazard Mater

PubMed ID: 35816794

Doi: 10.1016/j.jhazmat.2022.129499

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PLAA suppresses ovarian cancer metastasis via METTL3-mediated mA modification of TRPC3 mRNA

Authors: Zhangjin Shen, Lingkai Gu, Yuwan Liu, Lingfang Wang, Jiawei Zhu, Sangsang Tang, Xinyi Wei, Jiaying Wang, Songfa Zhang, Xinyu Wang, Xiaodong Cheng, Xing Xie, Weiguo Lu

Journal: Oncogene

PubMed ID: 35869392

Doi: 10.1038/s41388-022-02411-w

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Membrane Permeabilization and Antimicrobial Activity of Recombinant Defensin-d2 and Actifensin against Multidrug-Resistant and

Authors: Ifeoluwa D Gbala, Rosaline W Macharia, Joel L Bargul, Gabriel Magoma

Journal: Molecules

PubMed ID: 35889198

Doi: 10.3390/molecules27144325

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Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells

Authors: Dave Francisco, Ying Wang, Craig Marshall, Michelle Conway, Kenneth J Addison, Dean Billheimer, Hiroki Kimura, Mari Numata, Hong W Chu, Dennis R Voelker, Monica Kraft, Julie G Ledford

Journal: Front Immunol

PubMed ID: 35874703

Doi: 10.3389/fimmu.2022.900022

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Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis

Authors: Clint M Upchurch, Scott Yeudall, Caitlin M Pavelec, Dennis Merk, Jan Greulich, Mohan Manjegowda, Shyam S Raghavan, Irina M Bochkis, Michael M Scott, Edward Perez-Reyes, Norbert Leitinger

Journal: Sci Adv

PubMed ID: 35857497

Doi: 10.1126/sciadv.abn0050

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A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis

Authors: Namrata Bora-Singhal, Biswarup Saha, Durairaj Mohankumar, Jaya Padmanabhan, Domenico Coppola, Srikumar Chellappan

Journal: Cancer Res Commun

PubMed ID: 35937460

Doi: 10.1158/2767-9764.crc-21-0084

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Assessment of neutralizing antibody responses after natural SARS-CoV-2 infection and vaccination in congolese individuals

Authors: Armel Landry Batchi-Bouyou, Jean Claude Djontu, Jeannhey Christevy Vouvoungui, Claujens Chastel Mfoutou Mapanguy, Line Lobaloba Ingoba, Jiré Séphora Mougany, Kamal Rauchelvy Boumpoutou, Steve Diafouka-Kietela, Raoul Ampa, Francine Ntoumi

Journal: BMC Infect Dis

PubMed ID: 35831798

Doi: 10.1186/s12879-022-07593-y

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The two-domain elevator-type mechanism of zinc-transporting ZIP proteins

Authors: Anders Wiuf, Jonas Hyld Steffen, Eva Ramos Becares, Christina Grønberg, Dhani Ram Mahato, Søren G F Rasmussen, Magnus Andersson, Tristan Croll, Kamil Gotfryd, Pontus Gourdon

Journal: Sci Adv

PubMed ID: 35857505

Doi: 10.1126/sciadv.abn4331

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Development of Highly Sensitive Sandwich ELISA for the Early-Phase Diagnosis of Chikungunya Virus Utilizing rE2-E1 Protein

Authors: Mohammad Islamuddin, Abuzer Ali, Wajihul Hasan Khan, Amena Ali, Syed Kazim Hasan, Mohd Abdullah, Kentaro Kato, Malik Zainul Abdin, Shama Parveen

Journal: Infect Drug Resist

PubMed ID: 35924014

Doi: 10.2147/IDR.S347545

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Cutting Edge: Promoting T Cell Factor 1 T Cell Self-Renewal to Improve Programmed Cell Death Protein 1 Blockade

Authors: Peter H Wang, Robert Washburn, Rohan Maniar, Michael Mu, Olivia Ringham, Radomir Kratchmarov, Brian S Henick, Steven L Reiner

Journal: J Immunol

PubMed ID: 35905999

Doi: 10.4049/jimmunol.2200317

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Proteomic Network of Antibiotic-Induced Outer Membrane Vesicles Released by Extensively Drug-Resistant Elizabethkingia anophelis

Authors: Ming-Hsien Chiang, Fang-Ju Chang, Dinesh Kumar Kesavan, Aparna Vasudevan, Huaxi Xu, Kuo-Lun Lan, Shu-Wei Huang, Hung-Sheng Shang, Yi-Ping Chuang, Ya-Sung Yang, Te-Li Chen

Journal: Microbiol Spectr

PubMed ID: 35852325

Doi: 10.1128/spectrum.00262-22

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HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics

Authors: Matthew D Surette, Nicholas Waglechner, Kalinka Koteva, Gerard D Wright

Journal: Mol Cell

PubMed ID: 35907401

Doi: 10.1016/j.molcel.2022.06.019

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Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal

Authors: Huiyun Liu, Daniel Heller-Trulli, Claire L Moore

Journal: iScience

PubMed ID: 35992060

Doi: 10.1016/j.isci.2022.104804

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Combined strategies for suppressing nonspecific cationic adduction to G-quadruplexes in electrospray ionization mass spectrometry

Authors: Wen Lei, Jun Hu, Hong-Yuan Chen, Jing-Juan Xu

Journal: Anal Chim Acta

PubMed ID: 35868693

Doi: 10.1016/j.aca.2022.340146

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Optimized peptide extraction method for analysis of antimicrobial peptide Kn2-7/dKn2-7 stability in human serum by LC-MS

Authors: Wen Chen, Dickson Kirui, Nancy J Millenbaugh

Journal: Future Sci OA

PubMed ID: 35909998

Doi: 10.2144/fsoa-2022-0013

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CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1

Authors: Yixuan Lu, Yongxin Mu, Ju Chen, Xinyuan Guan, Ling Guo, Chuanyue Wu

Journal: Theranostics

PubMed ID: 35836803

Doi: 10.7150/thno.72365

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A multiple-target mRNA-LNP vaccine induces protective immunity against experimental multi-serotype DENV in mice

Authors: Lihong He, Wenqiang Sun, Limin Yang, Wenjun Liu, Jing Li

Journal: Virol Sin

PubMed ID: 35835315

Doi: 10.1016/j.virs.2022.07.003

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Comparing methods for immobilizing HIV-1 SOSIPs in ELISAs that evaluate antibody binding

Authors: Kim-Marie A Dam, Patricia S Mutia, Pamela J Bjorkman

Journal: Sci Rep

PubMed ID: 35778473

Doi: 10.1038/s41598-022-15506-x

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A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding

Authors: Brooke D Huisman, Zheng Dai, David K Gifford, Michael E Birnbaum

Journal: Elife

PubMed ID: 35781135

Doi: 10.7554/eLife.78589

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Pneumolysin suppresses the initial macrophage pro-inflammatory response to Streptococcus pneumoniae

Authors: Jimstan Periselneris, Carolin T Turner, Giuseppe Ercoli, Gabriella Szylar, Caroline M Weight, Teresa Thurston, Matthew Whelan, Gillian Tomlinson, Mahdad Noursadeghi, Jeremy Brown

Journal: Immunology

PubMed ID: 35835695

Doi: 10.1111/imm.13546

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Evaluation of residue variability in a conformation-specific context and during evolutionary sequence reconstruction narrows drug resistance selection in Abl1 tyrosine kinase

Authors: Felipe A M Otsuka, Sinisa Bjelic

Journal: Protein Sci

PubMed ID: 35762721

Doi: 10.1002/pro.4354

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Connexin 43 overexpression induces lung cancer angiogenesis following phosphorylation at Ser279 in its C-terminus

Authors: Zizi Zhou, Wenxiang Chai, Yi Liu, Yao Liu, Huiyu Pan, Qiang Wu, Xiaoming Zhang

Journal: Oncol Lett

PubMed ID: 35949588

Doi: 10.3892/ol.2022.13413

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Differences in Linear Epitopes of Ara h 9 Recognition in Peanut Allergic and Tolerant, Peach Allergic Patients

Authors: L Sánchez-Ruano, C Fernández-Lozano, M Ferrer, F Gómez, B de la Hoz, J Martínez-Botas, M J Goikoetxea

Journal: Front Allergy

PubMed ID: 35935018

Doi: 10.3389/falgy.2022.896617

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Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ

Authors: Qian Zhou, Wan-Wan Sun, Jia-Cong Chen, Hui-Lu Zhang, Jie Liu, Yan Lin, Peng-Cheng Lin, Bai-Xing Wu, Yan-Peng An, Lin Huang, Wen-Xing Sun, Xin-Wen Zhou, Yi-Ming Li, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao

Journal: Nat Commun

PubMed ID: 35879296

Doi: 10.1038/s41467-022-32000-0

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