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In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus

Authors: Linda B Oyama, Hamza Olleik, Ana Carolina Nery Teixeira, Matheus M Guidini, James A Pickup, Brandon Yeo Pei Hui, Nicolas Vidal, Alan R Cookson, Hannah Vallin, Toby Wilkinson, Denise M S Bazzolli, Jennifer Richards, Mandy Wootton, Ralf Mikut, Kai Hilpert, Marc Maresca, Josette Perrier, Matthias Hess, Hilario C Mantovani, Narcis Fernandez-Fuentes, Christopher J Creevey, Sharon A Huws

Journal: NPJ Biofilms Microbiomes

PubMed ID: 35835775

Doi: 10.1038/s41522-022-00320-0

Products & Services: Proteins, Expression, Isolation and Analysis

Sequence grammar underlying the unfolding and phase separation of globular proteins

Authors: Kiersten M Ruff, Yoon Hee Choi, Dezerae Cox, Angelique R Ormsby, Yoochan Myung, David B Ascher, Sheena E Radford, Rohit V Pappu, Danny M Hatters

Journal: Mol Cell

PubMed ID: 35853451

Doi: 10.1016/j.molcel.2022.06.024

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The Patterning and Proportion of Charged Residues in the Arginine-Rich Mixed-Charge Domain Determine the Membrane-Less Organelle Targeted by the Protein

Authors: Tamami Miyagi, Rio Yamazaki, Koji Ueda, Satoshi Narumi, Yuhei Hayamizu, Hiroshi Uji-I, Masahiko Kuroda, Kohsuke Kanekura

Journal: Int J Mol Sci

PubMed ID: 35887012

Doi: 10.3390/ijms23147658

Products & Services: Bacterial Expression

Conformational landscape of the yeast SAGA complex as revealed by cryo-EM

Authors: Diana Vasyliuk, Joeseph Felt, Ellen D Zhong, Bonnie Berger, Joseph H Davis, Calvin K Yip

Journal: Sci Rep

PubMed ID: 35853968

Doi: 10.1038/s41598-022-16391-0

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos

Authors: Fanye Meng, Chenxi Xu, Kwang-Su Park, H Ümit Kaniskan, Gang Greg Wang, Jian Jin

Journal: J Med Chem

PubMed ID: 35895319

Doi: 10.1021/acs.jmedchem.2c00807

Products & Services: Plasmid DNA Preparation

Cholesterol Deprivation Drives DHEA Biosynthesis in Human Adrenals

Authors: Emanuele Pignatti, Emre Murat Altinkilic, Konstantin Bräutigam, Michael Grössl, Aurel Perren, Mihaela Zavolan, Christa E Flück

Journal: Endocrinology

PubMed ID: 35583599

Doi: 10.1210/endocr/bqac076

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Screening circular RNAs with functional potential using the RfxCas13d/BSJ-gRNA system

Authors: Siqi Li, Hao Wu, Ling-Ling Chen

Journal: Nat Protoc

PubMed ID: 35831613

Doi: 10.1038/s41596-022-00715-5

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An Engineered λ Phage Enables Enhanced and Strain-Specific Killing of Enterohemorrhagic Escherichia coli

Authors: Menglu Jin, Jingchao Chen, Xueyang Zhao, Guoru Hu, Hailei Wang, Zhi Liu, Wei-Hua Chen

Journal: Microbiol Spectr

PubMed ID: 35876591

Doi: 10.1128/spectrum.01271-22

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Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut

Authors: Víctor Taleb, Qinghua Liao, Yoshiki Narimatsu, Ana García-García, Ismael Compañón, Rafael Junqueira Borges, Andrés Manuel González-Ramírez, Francisco Corzana, Henrik Clausen, Carme Rovira, Ramon Hurtado-Guerrero

Journal: Nat Commun

PubMed ID: 35882872

Doi: 10.1038/s41467-022-32021-9

Products & Services: Mutagenesis Services

Rhesus rotavirus receptor-binding site affects high mobility group box 1 release, altering the pathogenesis of experimental biliary atresia

Authors: Sujit K Mohanty, Bryan Donnelly, Haley Temple, Sarah Mowery, Holly M Poling, Jaroslaw Meller, Astha Malik, Monica McNeal, Greg Tiao

Journal: Hepatol Commun

PubMed ID: 35866580

Doi: 10.1002/hep4.2024

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The transient expression of recombinant proteins in plant cell packs facilitates stable isotope labelling for NMR spectroscopy

Authors: Patrick Opdensteinen, Laura E Sperl, Mariam Mohamadi, Nicole Kündgen-Redding, Franz Hagn, Johannes Felix Buyel

Journal: Plant Biotechnol J

PubMed ID: 35702941

Doi: 10.1111/pbi.13873

Products & Services: Proteins, Expression, Isolation and Analysis

Antitumor efficacy of MUC1-derived variable epitope library treatments in a mouse model of breast cancer

Authors: Josué Odales, Rodolfo Servín-Blanco, Fernando Martínez-Cortés, Jesus Guzman Valle, Allan Noé Domínguez-Romero, Goar Gevorkian, Karen Manoutcharian

Journal: Vaccine

PubMed ID: 35788294

Doi: 10.1016/j.vaccine.2022.06.062

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O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1

Authors: Qiang Zhu, Hong Zhou, Liming Wu, Zhenyuan Lai, Didi Geng, Weiwei Yang, Jie Zhang, Zhiya Fan, Weijie Qin, Yong Wang, Ruhong Zhou, Wen Yi

Journal: Nat Chem Biol

PubMed ID: 35879546

Doi: 10.1038/s41589-022-01085-5

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Reprogramming of Human B Cells from Secreting IgG to IgM by Genome Editing

Authors: Guigao Lin, Kuo Zhang, Yanxi Han, Rongxue Peng, Jiawei Zhang, Dandan Li, Jinming Li

Journal: CRISPR J

PubMed ID: 35900273

Doi: 10.1089/crispr.2021.0093

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Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice

Authors: Yuning Liu, Hong Xing, Alexis F Ernst, Canna Liu, Christian Maugee, Fumiaki Yokoi, Madepalli Lakshmana, Yuqing Li

Journal: Mol Cell Neurosci

PubMed ID: 35843530

Doi: 10.1016/j.mcn.2022.103756

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Bacteria deplete deoxynucleotides to defend against bacteriophage infection

Authors: Nitzan Tal, Adi Millman, Avigail Stokar-Avihail, Taya Fedorenko, Azita Leavitt, Sarah Melamed, Erez Yirmiya, Carmel Avraham, Alexander Brandis, Tevie Mehlman, Gil Amitai, Rotem Sorek

Journal: Nat Microbiol

PubMed ID: 35817891

Doi: 10.1038/s41564-022-01158-0

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Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge

Authors: Shanna S Leventhal, Kimberly Meade-White, Deepashri Rao, Elaine Haddock, Jacqueline Leung, Dana Scott, Jacob Archer, Samantha Randall, Jesse H Erasmus, Heinz Feldmann, David W Hawman

Journal: EBioMedicine

PubMed ID: 35907368

Doi: 10.1016/j.ebiom.2022.104188

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Tumor-Localized Administration of α-GalCer to Recruit Invariant Natural Killer T Cells and Enhance Their Antitumor Activity against Solid Tumors

Authors: Yan-Ruide Li, Yang Zhou, Matthew Wilson, Adam Kramer, Ryan Hon, Yichen Zhu, Ying Fang, Lili Yang

Journal: Int J Mol Sci

PubMed ID: 35886891

Doi: 10.3390/ijms23147547

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Paraneoplastic Pemphigus Autoantibodies Against C-terminus of Desmoplakin Induced Acantholysis and

Authors: Xue Wang, Rui Wang, Dingfang Bu, Leyi Wang, Yuexin Zhang, Yuan Chang, Chenyang Zhang, Xixue Chen, Xuejun Zhu, Zhi Liu, Mingyue Wang

Journal: Front Immunol

PubMed ID: 35911677

Doi: 10.3389/fimmu.2022.886226

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Protective effects of small heat shock proteins in Daphnia magna against heavy metal exposure

Authors: Muyi Li, Ting Tang, Fengyu Yuan, Yuming Zhang, Fengchao Li, Fengsong Liu

Journal: Sci Total Environ

PubMed ID: 35907523

Doi: 10.1016/j.scitotenv.2022.157565

Products & Services: Proteins, Expression, Isolation and Analysis

Development and applications of a TaqMan based quantitative real-time PCR for the rapid detection of Pigeon circovirus (PiCV)

Authors: Babu K Nath, Shubhagata Das, Tridip Das, Jade K Forwood, Shane R Raidal

Journal: J Virol Methods

PubMed ID: 35870671

Doi: 10.1016/j.jviromet.2022.114588

Products & Services: Proteins, Expression, Isolation and Analysis

The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE mice

Authors: Yishi Shen, Hong-Mei Gu, Lei Zhai, Binxiang Wang, Shucun Qin, Da-Wei Zhang

Journal: Biochim Biophys Acta Mol Cell Biol Lipids

PubMed ID: 35803528

Doi: 10.1016/j.bbalip.2022.159196

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Development and Assessment of Herpes Simplex Virus Type 1 (HSV-1) Amplicon Vectors with Sensory Neuron-Selective Promoters

Authors: Charles Joussain, Olivier Le Coz, Andrey Pichugin, Peggy Marconi, Filip Lim, Mariaconcetta Sicurella, Keith Foster, François Giuliano, Alberto L Epstein, Alejandro Aranda Muñoz

Journal: Int J Mol Sci

PubMed ID: 35955608

Doi: 10.3390/ijms23158474

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Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis

Authors: Nikola Kenjić, Kathleen M Meneely, Daniel J Wherritt, Melissa C Denler, Timothy A Jackson, Graham R Moran, Audrey L Lamb

Journal: J Am Chem Soc

PubMed ID: 35802469

Doi: 10.1021/jacs.2c03376

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Impacts of a Zwitterionic Peptide on its Fusion Protein

Authors: Patrick McMullen, Liang Fang, Qi Qiao, Qing Shao, Shaoyi Jiang

Journal: Bioconjug Chem

PubMed ID: 35852436

Doi: 10.1021/acs.bioconjchem.2c00176

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Immunogenicity of the third and fourth BNT162b2 mRNA COVID-19 boosters and factors associated with immune response in patients with SLE and rheumatoid arthritis

Authors: Theerada Assawasaksakul, Seelwan Sathitratanacheewin, Preeyaporn Vichaiwattana, Nasamon Wanlapakorn, Yong Poovorawan, Yingyos Avihingsanon, Nawaporn Assawasaksakul, Wonngarm Kittanamongkolchai

Journal: Lupus Sci Med

PubMed ID: 35902168

Doi: 10.1136/lupus-2022-000726

HOXB5-activated ANGPT2 promotes the proliferation, migration, invasion and angiogenic effect of esophageal cancer cells via activating ERK/AKT signaling pathway

Authors: Jing Li, Shanshan Gao

Journal: Exp Ther Med

PubMed ID: 35949323

Doi: 10.3892/etm.2022.11522

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The Relative Positioning of B and T Cell Epitopes Drives Immunodominance

Authors: Riccardo Biavasco, Marco De Giovanni

Journal: Vaccines (Basel)

PubMed ID: 36016115

Doi: 10.3390/vaccines10081227

Products & Services: Mammalian Expression

Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation

Authors: Charline Mary, Mona Hoseini Soflaee, Rushendhiran Kesavan, Muriel Gelin, Harrison Brown, G Zacharias, Thomas P Mathews, Andrew Lemoff, Corinne Lionne, Gilles Labesse, Gerta Hoxhaj

Journal: Mol Cell

PubMed ID: 35868311

Doi: 10.1016/j.molcel.2022.06.026

Products & Services: Mammalian Expression

A Novel Cre/lox71-Based System for Inducible Expression of Recombinant Proteins and Genome Editing

Authors: Maxim Karagyaur, Daniyar Dyikanov, Pyotr Tyurin-Kuzmin, Stalik Dzhauari, Mariya Skryabina, Maksim Vigovskiy, Alexandra Primak, Natalia Kalinina, Vsevolod Tkachuk

Journal: Cells

PubMed ID: 35883584

Doi: 10.3390/cells11142141

Products & Services: Plasmid DNA Preparation

ArsR Family Regulator MSMEG_6762 Mediates the Programmed Cell Death by Regulating the Expression of HNH Nuclease in Mycobacteria

Authors: Xiangke Duan, Xue Huang, Junqi Xu, Xue Li, Jingjing Niu, Xiaoli Du, Xiaoyu Wang, Jiang Li, Michael Kelly, Jiaohan Guo, Ke Zhang, Yu Huang, Biao Kan, Jianping Xie

Journal: Microorganisms

PubMed ID: 36013953

Doi: 10.3390/microorganisms10081535

Products & Services: Proteins, Expression, Isolation and Analysis

Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis

Authors: Yize Liu, Guanzhen Qiu, Yinzhou Luo, Shanshan Li, Yeqiu Xu, Yuanzhuang Zhang, Jiayuan Hu, Peifeng Li, Hai Pan, Yong Wang

Journal: Exp Mol Med

PubMed ID: 35879346

Doi: 10.1038/s12276-022-00806-z

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Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents

Authors: Jiyun Zhu, Linfeng Li, Aleksandra Drelich, Bala C Chenna, Drake M Mellott, Zane W Taylor, Vivian Tat, Christopher Z Garcia, Ardala Katzfuss, Chien-Te K Tseng, Thomas D Meek

Journal: Front Chem

PubMed ID: 35860632

Doi: 10.3389/fchem.2022.867928

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Comprehensive Evaluation and Comparison of Machine Learning Methods in QSAR Modeling of Antioxidant Tripeptides

Authors: Zhenjiao Du, Donghai Wang, Yonghui Li

Journal: ACS Omega

PubMed ID: 35910147

Doi: 10.1021/acsomega.2c03062

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Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes

Authors: Jean Mukherjee, Celinia A Ondeck, Jacqueline M Tremblay, Jacob Archer, Michelle Debatis, Alexa Foss, Junya Awata, Jesse H Erasmus, Patrick M McNutt, Charles B Shoemaker

Journal: Sci Rep

PubMed ID: 35803998

Doi: 10.1038/s41598-022-15876-2

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Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures

Authors: Marlen Kruse, Basma Altattan, Eva-Maria Laux, Nico Grasse, Lars Heinig, Christin Möser, David M Smith, Ralph Hölzel

Journal: Sci Rep

PubMed ID: 35896714

Doi: 10.1038/s41598-022-16914-9

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HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations

Authors: Yong Du, Yongfeng Chen, Yuxia Wang, Jinju Chen, Xiaorong Lu, Li Zhang, Yan Li, Zhaofu Wang, Guozhong Ye, George Zhang

Journal: Mol Cancer Ther

PubMed ID: 35499406

Doi: 10.1158/1535-7163.MCT-21-0835

Products & Services: Proteins, Expression, Isolation and Analysis

Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis

Authors: Zachary Armstrong, Richard W Meek, Liang Wu, James N Blaza, Gideon J Davies

Journal: Structure

PubMed ID: 35907402

Doi: 10.1016/j.str.2022.07.001

Products & Services: Mutant Libraries

Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis

Authors: Wenli Liu, Nataliya Östberg, Mustafa Yalcinkaya, Huijuan Dou, Kaori Endo-Umeda, Yang Tang, Xintong Hou, Tong Xiao, Trevor P Fidler, Sandra Abramowicz, Yong-Guang Yang, Oliver Soehnlein, Alan R Tall, Nan Wang

Journal: J Clin Invest

PubMed ID: 35587375

Doi: 10.1172/JCI155724

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Construction of a Novel Clinical Stage-Related Gene Signature for Predicting Outcome and Immune Response in Hepatocellular Carcinoma

Authors: Liu Yang, Long-Fei Zeng, Guo-Qing Hong, Qing Luo, Xing Lai

Journal: J Immunol Res

PubMed ID: 35865652

Doi: 10.1155/2022/6535009

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Silencing lncRNA 93358 Inhibits the Apoptosis of Myocardial Cells in Myocardial Infarction Rats by Inducing the Expression of SLC8A1

Authors: Jiumei Cai, Xiaoping Wang, Wei Liao, Yiming Zhong, Lingling Chen, Zhiwei Zhang

Journal: Biomed Res Int

PubMed ID: 35845941

Doi: 10.1155/2022/1138709

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Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism

Authors: Yong-Gang Chang, Christopher J Lupton, Charles Bayly-Jones, Alastair C Keen, Laura D'Andrea, Christina M Lucato, Joel R Steele, Hari Venugopal, Ralf B Schittenhelm, James C Whisstock, Michelle L Halls, Andrew M Ellisdon

Journal: Nat Struct Mol Biol

PubMed ID: 35864164

Doi: 10.1038/s41594-022-00804-9

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Diminished T-cell immune responses to SARS-CoV-2 omicron variant after BNT162b2 vaccination

Authors: Stanley C Jordan, Bong-Ha Shin, Edgar Rodriguez, Ashley Vo, Ruan Zhang

Journal: Immunol Lett

PubMed ID: 35843362

Doi: 10.1016/j.imlet.2022.07.004

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Intranasal administration of a live-attenuated recombinant newcastle disease virus expressing the SARS-CoV-2 Spike protein induces high neutralizing antibody levels and protects from experimental challenge infection in hamsters

Authors: Rik L de Swart, Olav S de Leeuw, Nadia Oreshkova, Nora M Gerhards, Irina C Albulescu, Sandra Vreman, José L Gonzales, Riks Maas, Frank J M van Kuppeveld, Peter Soema, Berend-Jan Bosch, Ben P H Peeters

Journal: Vaccine

PubMed ID: 35820941

Doi: 10.1016/j.vaccine.2022.07.005

Products & Services: Mammalian Expression

Large-scale application of free energy perturbation calculations for antibody design

Authors: Fangqiang Zhu, Feliza A Bourguet, William F D Bennett, Edmond Y Lau, Kathryn T Arrildt, Brent W Segelke, Adam T Zemla, Thomas A Desautels, Daniel M Faissol

Journal: Sci Rep

PubMed ID: 35864134

Doi: 10.1038/s41598-022-14443-z

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Translating a Thin-Film Rehydration Method to Microfluidics for the Preparation of a SARS-CoV-2 DNA Vaccine: When Manufacturing Method Matters

Authors: Allegra Peletta, Eakachai Prompetchara, Kittipan Tharakhet, Papatsara Kaewpang, Supranee Buranapraditkun, Nongnaphat Yostrerat, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Jonathan Avaro, Leonard Krupnik, Antonia Neels, Kiat Ruxrungtham, Chutitorn Ketloy, Gerrit Borchard

Journal: Pharmaceutics

PubMed ID: 35890321

Doi: 10.3390/pharmaceutics14071427

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From functional genomics of vero cells to CRISPR-based genomic deletion for improved viral production rates

Authors: Marie-Angélique Sène, Yu Xia, Amine A Kamen

Journal: Biotechnol Bioeng

PubMed ID: 35869699

Doi: 10.1002/bit.28190

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Interaction of Liberibacter Solanacearum with Host Psyllid Vitellogenin and Its Association with Autophagy

Authors: Poulami Sarkar, Murad Ghanim

Journal: Microbiol Spectr

PubMed ID: 35863005

Doi: 10.1128/spectrum.01577-22

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Ligand-induced transmembrane conformational coupling in monomeric EGFR

Authors: Shwetha Srinivasan, Raju Regmi, Xingcheng Lin, Courtney A Dreyer, Xuyan Chen, Steven D Quinn, Wei He, Matthew A Coleman, Kermit L Carraway, Bin Zhang, Gabriela S Schlau-Cohen

Journal: Nat Commun

PubMed ID: 35794108

Doi: 10.1038/s41467-022-31299-z

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NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections

Authors: Philippe Rascle, Cyril Planchais, Béatrice Jacquelin, Marie Lazzerini, Vanessa Contreras, Caroline Passaes, Asier Saez-Cirion, Hugo Mouquet, Nicolas Huot, Michaela Müller-Trutwin

Journal: Commun Biol

PubMed ID: 35798936

Doi: 10.1038/s42003-022-03619-y

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Structural, functional, and immunogenicity implications of F9 gene recoding

Authors: Upendra K Katneni, Aikaterini Alexaki, Ryan C Hunt, Nobuko Hamasaki-Katagiri, Gaya K Hettiarachchi, Jacob M Kames, Joseph R McGill, David D Holcomb, John C Athey, Brian Lin, Leonid A Parunov, Tal Kafri, Qi Lu, Robert Peters, Mikhail V Ovanesov, Darón I Freedberg, Haim Bar, Anton A Komar, Zuben E Sauna, Chava Kimchi-Sarfaty

Journal: Blood Adv

PubMed ID: 35413099

Doi: 10.1182/bloodadvances.2022007094

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Neutralizing antibody responses against SARS-CoV-2 in patients with plasma cell disorders who are on active treatment after two doses of mRNA vaccination

Authors: Al-Ola Abdallah, Zahra Mahmoudjafari, Tahani Atieh, Nausheen Ahmed, Wei Cui, Leyla Shune, Meera Mohan, Joseph McGuirk, Cassie Remker, Margaret Foss, Ellie Karloff, Heather Fitch, Shebli Atrash

Journal: Eur J Haematol

PubMed ID: 35810359

Doi: 10.1111/ejh.13826

Highly Effective Markerless Genetic Manipulation of Using a Mutated PheS-Based Counterselectable Marker

Authors: Guangjuan Gao, Dong Wei, Gang Li, Ping Chen, Liujun Wu, Siguo Liu, Yueling Zhang

Journal: Front Microbiol

PubMed ID: 35910605

Doi: 10.3389/fmicb.2022.947821

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CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7

Authors: Yong Zi Tan, Yazan M Abbas, Jing Ze Wu, Di Wu, Kristine A Keon, Geoffrey G Hesketh, Stephanie A Bueler, Anne-Claude Gingras, Carol V Robinson, Sergio Grinstein, John L Rubinstein

Journal: Life Sci Alliance

PubMed ID: 35794005

Doi: 10.26508/lsa.202201527

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Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Authors: Gamma Chi , Qiansheng Liang , Akshay Sridhar , John B Cowgill , Kasim Sader , Mazdak Radjainia , Pu Qian , Pablo Castro-Hartmann , Shayla Venkaya , Nanki Kaur Singh , Gavin McKinley , Alejandra Fernandez-Cid , Shubhashish M M Mukhopadhyay , Nicola A Burgess-Brown , Lucie Delemotte , Manuel Covarrubias , Katharina L Dürr

Journal: Nat Commun

PubMed ID: 35840580

Doi: 10.1038/s41467-022-29594-w

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Induction of Broadly Cross-Reactive Antibody Responses to SARS-CoV-2 Variants by S1 Nanoparticle Vaccines

Authors: Cong Sun , Run-Yu Yuan , Chu Xie , Jiu-Feng Sun , Xin-Yan Fang , Yi-Sha Hu , Xiao-Hui Yu, Zheng Liu , Mu-Sheng Zeng , Yin-Feng Kang

Journal: J Virol

PubMed ID: 35699445

Doi: 10.1128/jvi.00383-22

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A precise and efficient adenine base editor

Authors: Tianxiang Tu , Zongming Song , Xiaoyu Liu , Shengxing Wang , Xiaoxue He , Haitao Xi , Jiahua Wang , Tong Yan , Haoran Chen , Zhenwu Zhang , Xiujuan Lv , Jineng Lv , Xiu-Feng Huang , Junzhao Zhao , Chao-Po Lin , Caixia Gao , Jinwei Zhang , Feng Gu

Journal: Mol Ther

PubMed ID: 35821638

Doi: 10.1016/j.ymthe.2022.07.010

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Native Glucagon Amyloids Catalyze Key Metabolic Reactions

Authors: Elad Arad , Gal Yosefi , Sofiya Kolusheva , Ronit Bitton , Hanna Rapaport , Raz Jelinek

Journal: ACS Nano

PubMed ID: 35866668

Doi: 10.1021/acsnano.2c05166

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Rational development of a combined mRNA vaccine against COVID-19 and influenza

Authors: Qing Ye , Mei Wu , Chao Zhou , Xishan Lu , Baoying Huang , Ning Zhang , Hui Zhao , Hang Chi , Xiaojing Zhang , Dandan Ling , Rong-Rong Zhang , Zhuofan Li , Dan Luo , Yi-Jiao Huang , Hong-Ying Qiu , Haifeng Song , Wenjie Tan , Ke Xu , Bo Ying , Cheng-Feng Qin

Journal: npj Vaccines

PubMed ID: 35882870

Doi: 10.1038/s41541-022-00478-w

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Detection of Nipah and Hendra Viruses Using Recombinant Human Ephrin B2 Capture Virus in Immunoassays

Authors: Ming Yang , Wenjun Zhu , Thang Truong , Bradley Pickering , Shawn Babiuk , Darwyn Kobasa , Logan Banadyga

Journal: Viruses

PubMed ID: 36016279

Doi: 10.3390/v14081657

Products & Services: Proteins, Expression, Isolation and Analysis

Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults

Authors: Hassen Kared, Asia-Sophia Wolf, Amin Alirezaylavasani, Anthony Ravussin, Guri Solum, Trung The Tran, Fridtjof Lund-Johansen, John Torgils Vaage, Lise Sofie Nissen-Meyer, Unni C Nygaard, Olav Hungnes, Anna H Robertson, Lisbeth Meyer Næss, Lill Trogstad, Per Magnus, Ludvig A Munthe, Siri Mjaaland

Journal: Nat Commun

PubMed ID: 35851055

Doi: 10.1038/s41467-022-31888-y

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CC chemokine receptor 5 antagonist alleviates inflammation by regulating IFN-γ/IL-10 and STAT4/Smad3 signaling in a mouse model of autoimmune encephalomyelitis

Authors: Sheikh F Ahmad, Ahmed Nadeem, Mushtaq A Ansari, Saleh A Bakheet, Mudassar Shahid, Haneen A Al-Mazroua, Homood M As Sobeai, Abdullah F Alasmari, Mohammed M Alanazi, Abdullah S Alhamed, Abdullah A Aldossari, Sabry M Attia

Journal: Cell Immunol

PubMed ID: 35872534

Doi: 10.1016/j.cellimm.2022.104580

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Persistent Reptarenavirus and Hartmanivirus Infection in Cultured Boid Cells

Authors: Annika Lintala, Leonora Szirovicza, Anja Kipar, Udo Hetzel, Jussi Hepojoki

Journal: Microbiol Spectr

PubMed ID: 35862992

Doi: 10.1128/spectrum.01585-22

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Characterization of Dense Granule Metalloproteinase INS-16 in

Authors: Hao Cui, Rui Xu, Yu Li, Yaqiong Guo, Ziding Zhang, Lihua Xiao, Yaoyu Feng, Na Li

Journal: Int J Mol Sci

PubMed ID: 35886965

Doi: 10.3390/ijms23147617

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Analysis of FR901379 Biosynthetic Genes in by Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Based Genomic Manipulation

Authors: Teng-Yun Wei, Yan Zheng, Miyang Wan, Songbai Yang, Jiawei Tang, Yuanjie Wu, Jiyang Li, Shao-Xin Chen

Journal: ACS Chem Biol

PubMed ID: 35822391

Doi: 10.1021/acschembio.2c00250

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Genetic diversity of collaborative cross mice enables identification of novel rift valley fever virus encephalitis model

Authors: Haley N Cartwright, Dominique J Barbeau, Joshua D Doyle, Ed Klein, Mark T Heise, Martin T Ferris, Anita K McElroy

Journal: PLoS Pathog

PubMed ID: 35834486

Doi: 10.1371/journal.ppat.1010649

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Relaxin Affects Airway Remodeling Genes Expression through Various Signal Pathways Connected with Transcription Factors

Authors: Joanna Wieczfinska, Rafal Pawliczak

Journal: Int J Mol Sci

PubMed ID: 35955554

Doi: 10.3390/ijms23158413

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Peptide-siRNA nanoparticles targeting NF-κB p50 mitigate experimental abdominal aortic aneurysm progression and rupture

Authors: Huimin Yan, Ying Hu, Antonina Akk, Samuel A Wickline, Hua Pan, Christine T N Pham

Journal: Biomater Adv

PubMed ID: 35891603

Doi: 10.1016/j.bioadv.2022.213009

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Apela gene therapy alleviates pulmonary hypertension in rats

Authors: Yuexin Hu, Liangli Jin, Yang Pan, Jue Zou, Zhi Wang

Journal: FASEB J

PubMed ID: 35747913

Doi: 10.1096/fj.202200266R

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Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2

Authors: Mariana F Tioni, Robert Jordan, Angie Silva Pena, Aditya Garg, Danlu Wu, Shannon I Phan, Christopher M Weiss, Xing Cheng, Jack Greenhouse, Tatyana Orekov, Daniel Valentin, Swagata Kar, Laurent Pessaint, Hanne Andersen, Christopher C Stobart, Melissa H Bloodworth, R Stokes Peebles, Yang Liu, Xuping Xie, Pei-Yong Shi, Martin L Moore, Roderick S Tang

Journal: npj Vaccines

PubMed ID: 35906244

Doi: 10.1038/s41541-022-00509-6

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Polymeric nanoparticles for dual-targeted theranostic gene delivery to hepatocellular carcinoma

Authors: Hannah J Vaughan, Camila G Zamboni, Laboni F Hassan, Nicholas P Radant, Desmond Jacob, Ronnie C Mease, Il Minn, Stephany Y Tzeng, Kathleen L Gabrielson, Pranshu Bhardwaj, Xin Guo, David Francisco, Martin G Pomper, Jordan J Green

Journal: Sci Adv

PubMed ID: 35857843

Doi: 10.1126/sciadv.abo6406

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Programmable CRISPR-Cas9 microneedle patch for long-term capture and real-time monitoring of universal cell-free DNA

Authors: Bin Yang, Jilie Kong, Xueen Fang

Journal: Nat Commun

PubMed ID: 35810160

Doi: 10.1038/s41467-022-31740-3

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Genetically Encoded Aryl Alkyne for Raman Spectral Imaging of Intracellular α-Synuclein Fibrils

Authors: Matthew D Watson, Jennifer C Lee

Journal: J Mol Biol

PubMed ID: 35792158

Doi: 10.1016/j.jmb.2022.167716

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Silencing the enhancer of zeste homologue 2, E, represses axon regeneration of dorsal root ganglion neuronszh 2

Authors: Ting-Ting Guo, Ying Zhao, Wei-Xiao Huang, Tao Zhang, Li-Li Zhao, Xiao-Song Gu, Song-Lin Zhou

Journal: Neural Regen Res

PubMed ID: 34916437

Doi: 10.4103/1673-5374.330623

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A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry

Authors: Liangqin Tong, Lin Wang, Shumin Liao, Xiaoping Xiao, Jing Qu, Chunli Wu, Yibin Zhu, Wanbo Tai, Yanhong Huang, Penghua Wang, Liang Li, Renli Zhang, Ye Xiang, Gong Cheng

Journal: MBio

PubMed ID: 35862773

Doi: 10.1128/mbio.01485-22

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Stitchr: stitching coding TCR nucleotide sequences from V/J/CDR3 information

Authors: James M Heather, Matthew J Spindler, Marta Herrero Alonso, Yifang Ivana Shui, David G Millar, David S Johnson, Mark Cobbold, Aaron N Hata

Journal: Nucleic Acids Res

PubMed ID: 35325179

Doi: 10.1093/nar/gkac190

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Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

Authors: Jorge Franco, Francesco Piacente, Melanie Walter, Simone Fratta, Moustafa Ghanem, Andrea Benzi, Irene Caffa, Alexander V Kurkin, Andrea Altieri, Patrick Herr, Macarena Martínez-Bailén, Inmaculada Robina, Santina Bruzzone, Alessio Nencioni, Alberto Del Rio

Journal: Pharmaceuticals (Basel)

PubMed ID: 35890155

Doi: 10.3390/ph15070855

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Mycoplasma hyopneumoniae membrane protein Mhp271 interacts with host UPR protein GRP78 to facilitate infection

Authors: Qiao Pan, Qingyuan Xu, Tong Liu, Yujuan Zhang, Jiuqing Xin

Journal: Mol Microbiol

PubMed ID: 35791781

Doi: 10.1111/mmi.14963

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Optimization of Potent and Specific Trypanothione Reductase Inhibitors: A Structure-Based Drug Discovery Approach

Authors: Theo Battista, Stefano Federico, Simone Brogi, Luca Pozzetti, Tuhina Khan, Stefania Butini, Anna Ramunno, Eleonora Fiorentino, Stefania Orsini, Trentina Di Muccio, Annarita Fiorillo, Cécile Exertier, Daniel Di Risola, Gianni Colotti, Sandra Gemma, Andrea Ilari, Giuseppe Campiani

Journal: ACS Infect Dis

PubMed ID: 35880849

Doi: 10.1021/acsinfecdis.2c00325

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Grp94 Works Upstream of BiP in Protein Remodeling Under Heat Stress

Authors: Yaa S Amankwah, Preston Collins, Yasmeen Fleifil, Erin Unruh, Kevin J Ruiz Márquez, Katherine Vitou, Andrea N Kravats

Journal: J Mol Biol

PubMed ID: 35905823

Doi: 10.1016/j.jmb.2022.167762

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Proteomic and Phosphoproteomic Analyses Reveal Gibel Carp Responses to Cyprinid Herpesvirus 2 Infection

Authors: Chen Xu, Yiqun Li, Zidong Xiao, Jie Yang, Mingyang Xue, Nan Jiang, Yan Meng, Wenzhi Liu, Yuding Fan, Yong Zhou

Journal: J Proteome Res

PubMed ID: 35792615

Doi: 10.1021/acs.jproteome.2c00253

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[C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease

Authors: Tharick A Pascoal, Mira Chamoun, Elad Lax, Hsiao-Ying Wey, Monica Shin, Kok Pin Ng, Min Su Kang, Sulantha Mathotaarachchi, Andrea L Benedet, Joseph Therriault, Firoza Z Lussier, Frederick A Schroeder, Jonathan M DuBois, Baileigh G Hightower, Tonya M Gilbert, Nicole R Zürcher, Changning Wang, Robert Hopewell, Mallar Chakravarty, Melissa Savard, Emilie Thomas, Sara Mohaddes, Sarah Farzin, Alyssa Salaciak, Stephanie Tullo, A Claudio Cuello, Jean-Paul Soucy, Gassan Massarweh, Heungsun Hwang, Eliane Kobayashi, Bradley T Hyman, Bradford C Dickerson, Marie-Christine Guiot, Moshe Szyf, Serge Gauthier, Jacob M Hooker, Pedro Rosa-Neto

Journal: Nat Commun

PubMed ID: 35853847

Doi: 10.1038/s41467-022-30653-5

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Genome-wide CRISPR Screening Reveals Pyrimidine Metabolic Reprogramming in 5-FU Chronochemotherapy of Colorectal Cancer

Authors: Ya Niu, Xinyi Fan, Yaping Wang, Jiaxin Lin, Luchun Hua, Xiaobo Li, Ruizhe Qian, Chao Lu

Journal: Front Oncol

PubMed ID: 35903686

Doi: 10.3389/fonc.2022.949715

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Oral Administration with Recombinant Attenuated Regulated Delayed Lysis Vaccines Protecting against Kidney Abscess Formation

Authors: Yanchen Liang, Haochi Zhang, Na Pan, Yang Liu, Shouxin Sheng, Haotian Li, Xuemei Bao, Xiao Wang

Journal: Vaccines (Basel)

PubMed ID: 35891237

Doi: 10.3390/vaccines10071073

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A time-resolved, multi-symbol molecular recorder via sequential genome editing

Authors: Junhong Choi, Wei Chen, Anna Minkina, Florence M Chardon, Chase C Suiter, Samuel G Regalado, Silvia Domcke, Nobuhiko Hamazaki, Choli Lee, Beth Martin, Riza M Daza, Jay Shendure

Journal: Nature

PubMed ID: 35794474

Doi: 10.1038/s41586-022-04922-8

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Overexpression of the scopoletin biosynthetic pathway enhances lignocellulosic biomass processing

Authors: Lennart Hoengenaert, Marlies Wouters, Hoon Kim, Barbara De Meester, Kris Morreel, Steven Vandersyppe, Jacob Pollier, Sandrien Desmet, Geert Goeminne, John Ralph, Wout Boerjan, Ruben Vanholme

Journal: Sci Adv

PubMed ID: 35857515

Doi: 10.1126/sciadv.abo5738

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Pharmacokinetic Characteristics, Safety, and Tolerability of Telitacicept, an Injectable Recombinant Human B-Lymphocyte Stimulating Factor Receptor-Antibody Fusion Protein, in Healthy Chinese Subjects

Authors: Jing Xie, Xiaoyun Fan, Yue Su, Huan Zhou, Shugang Cao, Xingyu Zhu, Minhui Zhu, Cuixia He, Ying Wang, Ling Fan, Qin Ge, Juan Zhu, Bingyan Liu, Xiao Chen, Yunqiu Xie, Ling Ma, Yuanyuan Liu, Juan Chen, Huaxue Wang, Zhijun Li

Journal: Clin Pharmacol Drug Dev

PubMed ID: 35844038

Doi: 10.1002/cpdd.1136

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A biepitope, adjuvant-free, self-assembled influenza nanovaccine provides cross-protection against H3N2 and H1N1 viruses in mice

Authors: Yongbo Qiao, YaXin Zhang, Jie Chen, Shenghui Jin, Yaming Shan

Journal: Nano Res

PubMed ID: 35911479

Doi: 10.1007/s12274-022-4482-4

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Protective Human Anti-Poxvirus Monoclonal Antibodies Are Generated from Rare Memory B Cells Isolated by Multicolor Antigen Tetramers

Authors: Xiuling Gu, Yufan Zhang, Wei Jiang, Dongfang Wang, Jiao Lu, Guanglei Gu, Chengfeng Qin, Min Fang

Journal: Vaccines (Basel)

PubMed ID: 35891248

Doi: 10.3390/vaccines10071084

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A hydrogel platform for co-delivery of immunomodulatory proteins for pancreatic islet allografts

Authors: Juan D Medina, Graham F Barber, Maria M Coronel, Michael D Hunckler, Stephen W Linderman, Michelle J Quizon, Vahap Ulker, Esma S Yolcu, Haval Shirwan, Andrés J García

Journal: J Biomed Mater Res A

PubMed ID: 35841329

Doi: 10.1002/jbm.a.37429

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Neoantigen Identification and Response to Adoptive Cell Transfer in Anti-PD-1 Naïve and Experienced Patients with Metastatic Melanoma

Authors: Shoshana T Levi, Amy R Copeland, Shirley Nah, Jessica S Crystal, Gabriel D Ivey, Almin Lalani, Mohammad Jafferji, Bradley S White, Neilesh B Parikh, Vid Leko, Sri Krishna, Frank Lowery, Todd D Prickett, Jared J Gartner, Li Jia, Yong F Li, Abraham Sachs, Sivasish Sindiri, Welles Robinson, Billel Gasmi, James C Yang, Stephanie L Goff, Steven A Rosenberg, Paul F Robbins

Journal: Clin Cancer Res

PubMed ID: 35247926

Doi: 10.1158/1078-0432.CCR-21-4499

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Non-synergy of PD-1 blockade with T-cell therapy in solid tumors

Authors: John S Davies, Farrah Karimipour, Ling Zhang, Nisha Nagarsheth, Scott Norberg, Carylinda Serna, Julius Strauss, Shinheng Chiou, James L Gulley, Christian S Hinrichs

Journal: J Immunother Cancer

PubMed ID: 35793866

Doi: 10.1136/jitc-2022-004906

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An effective strategy for the humanization of antibody fragments under an accelerated timeline

Authors: Isabella Gizzi Jiacomini, Martina Beltramino, Fanny Boursin, João Carlos Minozzo, Juliana Ferreira de Moura, Philippe Billiald, Larissa Magalhães Alvarenga, Nicolas Aubrey

Journal: Int J Biol Macromol

PubMed ID: 35803408

Doi: 10.1016/j.ijbiomac.2022.06.195

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A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir

Authors: Subramanyam Vankadara, Monique Danielle Dawson, Jia Yi Fong, Qin Yao Oh, Qi An Ang, Boping Liu, Hong Yun Chang, Judice Koh, Xiaoying Koh, Qian Wen Tan, Joma Joy, Cheng San Brian Chia

Journal: ACS Med Chem Lett

PubMed ID: 35971455

Doi: 10.1021/acsmedchemlett.2c00260

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Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions

Authors: Mengying Liu, Liane Z X Huang, Anthony A Smits, Christian Büll, Yoshiki Narimatsu, Frank J M van Kuppeveld, Henrik Clausen, Cornelis A M de Haan, Erik de Vries

Journal: Nat Commun

PubMed ID: 35831293

Doi: 10.1038/s41467-022-31840-0

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Preclinical immunogenicity and efficacy of a candidate COVID-19 vaccine based on a vesicular stomatitis virus-SARS-CoV-2 chimera

Authors: Amy S Espeseth, Maoli Yuan, Michael Citron, Lucia Reiserova, Gavin Morrow, Aaron Wilson, Melanie Horton, Mark Rukhman, Keith Kinek, Fuxiang Hou, Shui L Li, Fengsheng Li, Yesle Choi, Gwen Heidecker, Bin Luo, Guoxin Wu, Lan Zhang, Erica Strable, Joanne DeStefano, Susan Secore, Tarit K Mukhopadhyay, Douglas D Richardson, Eddy Sayeed, Lisa S Welch, Andrew J Bett, Mark B Feinberg, Swati B Gupta, Christopher L Cooper, Christopher L Parks

Journal: EBioMedicine

PubMed ID: 35915046

Doi: 10.1016/j.ebiom.2022.104203

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CAR T-Cell Targeting of Macrophage Colony-Stimulating Factor Receptor

Authors: Daniela Yordanova Achkova, Richard Esmond Beatson, John Maher

Journal: Cells

PubMed ID: 35883636

Doi: 10.3390/cells11142190

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N-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs

Authors: Tien-Hao Chen, Vladimir Potapov, Nan Dai, Jennifer L Ong, Bijoyita Roy

Journal: Sci Rep

PubMed ID: 35906281

Doi: 10.1038/s41598-022-17249-1

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Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy

Authors: Christianne Groeneveldt, Priscilla Kinderman, Jordi J C van Stigt Thans, Camilla Labrie, Lisa Griffioen, Marjolein Sluijter, Diana J M van den Wollenberg, Rob C Hoeben, Joke M M den Haan, Sjoerd H van der Burg, Thorbald van Hall, Nadine van Montfoort

Journal: J Immunother Cancer

PubMed ID: 35853671

Doi: 10.1136/jitc-2021-004464

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Design of two immunotoxins based rovalpituzumab antibody against DLL3 receptor; a promising potential opportunity

Authors: Mohammad Hossein Ataee, Seyed Ali Mirhosseini, Reza Mirnejad, Ehsan Rezaie, Hamideh Mahmoodzadeh Hosseini, Jafar Amani

Journal: Res Pharm Sci

PubMed ID: 36034078

Doi: 10.4103/1735-5362.350243

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