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The role of CFA/I in adherence and toxin delivery by ETEC expressing multiple colonization factors in the human enteroid model
Authors: Emily M Smith, Christen L Grassel, Antonia Papadimas, Jennifer Foulke-Abel, Eileen M Barry
Journal: PLoS Negl Trop Dis
PubMed ID: 35881640
Doi: 10.1371/journal.pntd.0010638
Insight into bacterial community profiles of oil shale and sandstone in ordos basin by culture-dependent and culture-independent methods
Authors: Fengdan Wei, Rui Xu, Yuanyuan Xu, Tao Cheng, Yanling Ma
Journal: J Environ Sci Health A Tox Hazard Subst Environ Eng
PubMed ID: 35903918
Doi: 10.1080/10934529.2022.2105631
Products & Services: DNA Sequencing   
Enhancing epitope of PEDV spike protein
Authors: Techit Thavorasak, Monrat Chulanetra, Kittirat Glab-Ampai, Kodchakorn Mahasongkram, Nawannaporn Sae-Lim, Karsidete Teeranitayatarn, Thaweesak Songserm, Rungrueang Yodsheewan, Dachrit Nilubol, Wanpen Chaicumpa, Nitat Sookrung
Journal: Front Microbiol
PubMed ID: 35935230
Doi: 10.3389/fmicb.2022.933249
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Self-Assembling Protein Surfaces for Capture of Cell-Free-Synthesized Proteins
Authors: Ella Lucille Thornton, Sarah Maria Paterson, Zoe Gidden, Mathew H Horrocks, Nadanai Laohakunakorn, Lynne Regan
Journal: Front Bioeng Biotechnol
PubMed ID: 35875503
Doi: 10.3389/fbioe.2022.915035
Products & Services: Catalog Antibody   
Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2
Authors: Brandon Wey-Hung Liauw, Arash Foroutan, Michael R Schamber, Weifeng Lu, Hamid Samareh Afsari, Reza Vafabakhsh
Journal: Elife
PubMed ID: 35775730
Doi: 10.7554/eLife.78982
Products & Services: DNA Sequencing   
Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains
Authors: James Brett Case, Samantha Mackin, John M Errico, Zhenlu Chong, Emily A Madden, Bradley Whitener, Barbara Guarino, Michael A Schmid, Kim Rosenthal, Kuishu Ren, Ha V Dang, Gyorgy Snell, Ana Jung, Lindsay Droit, Scott A Handley, Peter J Halfmann, Yoshihiro Kawaoka, James E Crowe, Daved H Fremont, Herbert W Virgin, Yueh-Ming Loo, Mark T Esser, Lisa A Purcell, Davide Corti, Michael S Diamond
Journal: Nat Commun
PubMed ID: 35780162
Doi: 10.1038/s41467-022-31615-7
Products & Services: Polyclonal Antibody Services   
PTPRO knockdown protects against inflammation in hemorrhage shock-induced lung injury involving the NF-κB signaling pathway
Authors: Zhirong Huan, Ying Tang, Ce Xu, Jimin Cai, Hao Yao, Yan Wang, Fanyu Bu, Xin Ge
Journal: Respir Res
PubMed ID: 35906634
Doi: 10.1186/s12931-022-02118-2
Products & Services: Mammalian Expression   
Membrane fluidity, composition, and charge affect the activity and selectivity of the AMP ascaphin-8
Authors: Adriana Morales-Martínez, Brandt Bertrand, Juan M Hernández-Meza, Ramón Garduño-Juárez, Jesús Silva-Sanchez, Carlos Munoz-Garay
Journal: Biophys J
PubMed ID: 35842753
Doi: 10.1016/j.bpj.2022.07.018
Products & Services: GenCrispr Cas9 Genome Editing   
Construction of a T7 phage display nanobody library for bio-panning and identification of chicken dendritic cell-specific binding nanobodies
Authors: Hai Xu, Ling Li, Bihua Deng, Weiming Hong, Ruiting Li, Zijie Guo, Jibo Hou, Roshini Govinden, Hafizah Y Chenia
Journal: Sci Rep
PubMed ID: 35840654
Doi: 10.1038/s41598-022-16378-x
Products & Services: DNA Sequencing   
Ca attenuates nucleation activity of leiomodin
Authors: Garry E Smith, Dmitri Tolkatchev, Cristina Risi, Madison Little, Carol C Gregorio, Vitold E Galkin, Alla S Kostyukova
Journal: Protein Sci
PubMed ID: 35762710
Doi: 10.1002/pro.4358
A Single Vaccination of Chimeric Bivalent Virus-Like Particle Vaccine Confers Protection Against H9N2 and H3N2 Avian Influenza in Commercial Broilers and Allows a Strategy of Differentiating Infected from Vaccinated Animals
Authors: Yi-Xue Sun, Zheng-Rong Li, Peng-Ju Zhang, Jin-Hong Han, Hai-Yang Di, Jia-Yi Qin, Yan-Long Cong
Journal: Front Immunol
PubMed ID: 35874682
Doi: 10.3389/fimmu.2022.902515
Products & Services: Gene Synthesis   
Engineering a tunable bicistronic TetR autoregulation expression system in
Authors: Monica Bertucci, Ky Ariano, Meg Zumsteg, Paul Schweiger
Journal: PeerJ
PubMed ID: 35873911
Doi: 10.7717/peerj.13639
Products & Services: PCR Cloning and Subcloning   
Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus
Authors: Francesco Aulicino, Martin Pelosse, Christine Toelzer, Julien Capin, Erwin Ilegems, Parisa Meysami, Ruth Rollarson, Per-Olof Berggren, Mark Simon Dillingham, Christiane Schaffitzel, Moin A Saleem, Gavin I Welsh, Imre Berger
Journal: Nucleic Acids Res
PubMed ID: 35801912
Doi: 10.1093/nar/gkac587
Products & Services: Synthetic sgRNA and crRNA Service   
Durability of the Neutralizing Antibody Response to mRNA Booster Vaccination Against SARS-CoV-2 BA2121 and BA4/5 Variants
Authors: Panke Qu, Julia N Faraone, John P Evans, Yi-Min Zheng, Claire Carlin, Gerard Lozanski, Linda J Saif, Eugene M Oltz, Richard J Gumina, Shan-Lu Liu
Journal: biorxiv
PubMed ID: 35898337
Doi: 10.1101/2022.07.21.501010
Products & Services: Plasmid DNA Preparation   
Impact of the temperature on the interactions between common variants of the SARS-CoV-2 receptor binding domain and the human ACE2
Authors: Catherine Forest-Nault, Izel Koyuturk, Jimmy Gaudreault, Alex Pelletier, Denis L'Abbé, Brian Cass, Louis Bisson, Alina Burlacu, Laurence Delafosse, Matthew Stuible, Olivier Henry, Gregory De Crescenzo, Yves Durocher
Journal: Sci Rep
PubMed ID: 35798770
Doi: 10.1038/s41598-022-15215-5
Products & Services: Mammalian Expression   
Limited Correlation between SARS-CoV-2 Serologic Assays for Identification of High-Titer COVID-19 Convalescent Plasma Using FDA Thresholds
Authors: Nicholas E Larkey, Radwa Ewaisha, Michael A Lasho, Matthew M Roforth, Dane Granger, Calvin R Jerde, Liang Wu, Amy Gorsh, Stephen A Klassen, Jonathon W Senefeld, Michael J Joyner, Nikola A Baumann, Elitza S Theel, John R Mills
Journal: Microbiol Spectr
PubMed ID: 35862939
Doi: 10.1128/spectrum.01154-22
Pro-Survival Factor EDEM3 Confers Therapy Resistance in Prostate Cancer
Authors: Emma Scott, Rebecca Garnham, Kathleen Cheung, Adam Duxfield, David J Elliott, Jennifer Munkley
Journal: Int J Mol Sci
PubMed ID: 35897761
Doi: 10.3390/ijms23158184
Products & Services: Custom Vector Construction   
An adaptable platform for in-house hepatitis C serology
Authors: Jannie Pedersen, Irène Pegha Moukandja, Stella Ndidi, Anna-Louise Sørensen, Ismaël Hervé Koumakpayi, Jean-Bernard Lekana-Douki, Marie-Louise Vachon, Nina Weis, Gary Kobinger, Hugues Fausther-Bovendo
Journal: J Virol Methods
PubMed ID: 35850366
Doi: 10.1016/j.jviromet.2022.114586
Products & Services: Custom Vector Construction   
Physical activity and antibody persistence 6 months after the second dose of CoronaVac in immunocompromised patients
Authors: Bruno Gualano, Ítalo Ribeiro Lemes, Rafael Pires da Silva, Ana Jéssica Pinto, Bruna Caruso Mazzolani, Fabiana Infante Smaira, Sofia Mendes Sieczkowska, Nádia Emi Aikawa, Sandra Pasoto, Ana Cristina Medeiros-Ribeiro, Carla Saad, Emily Yuk, Clovis Silva, Paul Swinton, Pedro Curi Hallal, Hamilton Roschel, Eloisa Bonfa
Journal: Scand J Med Sci Sports
PubMed ID: 35844042
Doi: 10.1111/sms.14213
High Mobility Group Protein B1 Decreases Surface Localization of PD-1 to Augment T-cell Activation
Authors: Qun Gao, Shumin Wang, Feng Li, Jingyao Lian, Shaoyan Cheng, Dongli Yue, Zhen Zhang, Shasha Liu, Feifei Ren, Daiqun Zhang, Shengdian Wang, Liping Wang, Yi Zhang
Journal: Cancer Immunol Res
PubMed ID: 35580259
Doi: 10.1158/2326-6066.CIR-21-0652
Products & Services: Recombinant Proteins   
Structures of the T cell potassium channel Kv13 with immunoglobulin modulators
Authors: Purushotham Selvakumar, Ana I Fernández-Mariño, Nandish Khanra, Changhao He, Alice J Paquette, Bing Wang, Ruiqi Huang, Vaughn V Smider, William J Rice, Kenton J Swartz, Joel R Meyerson
Journal: Nat Commun
PubMed ID: 35788586
Doi: 10.1038/s41467-022-31285-5
Products & Services: Plasmid DNA Preparation   
Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition
Authors: Elena G Govorunova , Yueyang Gou , Oleg A Sineshchekov , Hai Li , Xiaoyu Lu , Yumei Wang , Leonid S Brown , François St-Pierre , Mingshan Xue , John L Spudich
Journal: Nature neuroscience
PubMed ID: 35726059
Doi: 10.1038/s41593-022-01094-6
Products & Services: Gene Synthesis   
Core cysteine residues in the Plasminogen-Apple-Nematode (PAN) domain are critical for HGF/c-MET signaling
Authors: Debjani Pal , Kuntal De , Carly M Shanks , Kai Feng , Timothy B Yates , Jennifer Morrell-Falvey , Russell B Davidson , Jerry M Parks , Wellington Muchero
Journal: Commun Biol
PubMed ID: 35778602
Doi: 10.1038/s42003-022-03582-8
Hsp70 inhibits the replication of Fowl Adenovirous serotype 4 by suppressing viral Hexon with the assistance of DnaJC7
Authors: Jie Cao , Shuhui Liu , Meng Liu , Shuaiwen Wang , Zhenwei Bi , Wentao Fan , Zhiyu Shi , Suquan Song , Liping Yan
Journal: J Virol
PubMed ID: 35852354
Doi: 10.1128/jvi.00807-22
Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker
Authors: Aslan Mansurov , Peyman Hosseinchi, Kevin Chang, Abigail L Lauterbach, Laura T Gray , Aaron T Alpar , Erica Budina , Anna J Slezak , Seounghun Kang, Shijie Cao, Ani Solanki , Suzana Gomes , John-Michael Williford, Melody A Swartz , Juan L Mendoza , Jun Ishihara , Jeffrey A Hubbell
Journal: Nat Biomed Eng
PubMed ID: 35534574
Doi: 10.1038/s41551-022-00888-0
Products & Services: Mammalian Expression   
Identification of nucleoside monophosphates and their epigenetic modifications using an engineered nanopore.
Authors: Yuqin Wang , Shanyu Zhang , Wendong Jia ,Pingping Fan , Liying Wang , Xinyue Li , Jialu Chen , Zhenyuan Cao , Xiaoyu Du , Yao Liu , Kefan Wang , Chengzhen Hu , Jinyue Zhang , Jun Hu , Panke Zhang , Hong-Yuan Chen , Shuo Huang
Journal: Nat Nanotechnol
PubMed ID: 35851382
Doi: 10.1038/s41565-022-01169-2
Products & Services: Gene Synthesis   
Oncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancer
Authors: Qiuman Wang , Xinyue Ma , Huan Wu , Chen Zhao 1, Jingying Chen , Rongrong Li , Shi Yan , Yingwei Li , Qing Zhang , Kun Song , Cunzhong Yuan , Beihua Kong
Journal: Oncoimmunology
PubMed ID: 35800156
Doi: 10.1080/2162402X.2022.2096362 Free PMC article
Developing and validating SARS-CoV-2 assays for nonhuman primate surveillance
Authors: JoAnn Yee, Amanda Carpenter, Peter Nham, Bryson Halley, Koen K A Van Rompay, Jeffrey Roberts
Journal: J Med Primatol
PubMed ID: 35794847
Doi: 10.1111/jmp.12604
Products & Services: Mammalian Expression   
CaMKII Inhibition Attenuates Distinct Gain-of-Function Effects Produced by Mutant Nav16 Channels and Reduces Neuronal Excitability
Authors: Agnes S Zybura, Firoj K Sahoo, Andy Hudmon, Theodore R Cummins
Journal: Cells
PubMed ID: 35805192
Doi: 10.3390/cells11132108
Products & Services: Mammalian Expression   
Efficient multiplex CRISPR/Cpf1 (Cas12a) genome editing system in Aspergillus aculeatus TBRC 277
Authors: Dede Abdulrachman, Verawat Champreda, Lily Eurwilaichitr, Duriya Chantasingh, Kusol Pootanakit
Journal: J Biotechnol
PubMed ID: 35788357
Doi: 10.1016/j.jbiotec.2022.06.011
Products & Services: Synthetic sgRNA and crRNA Service   
Ancestrally Reconstructed von Willebrand Factor Reveals Evidence for Trench Warfare Coevolution between Opossums and Pit Vipers
Authors: Danielle H Drabeck, Alexandra Rucavado, Erika Hingst-Zaher, Antony Dean, Sharon A Jansa
Journal: Mol Biol Evol
PubMed ID: 35723968
Doi: 10.1093/molbev/msac140
Products & Services: Gene Synthesis   
Calcium responses to external mechanical stimuli in the multicellular stage of Dictyostelium discoideum
Authors: Hidenori Hashimura, Yusuke V Morimoto, Yusei Hirayama, Masahiro Ueda
Journal: Sci Rep
PubMed ID: 35859163
Doi: 10.1038/s41598-022-16774-3
Products & Services: GenParts™ DNA Fragments   
miR-301b-5p and its target gene nfatc2ip regulate inflammatory responses in the liver of rainbow trout (Oncorhynchus mykiss) under high temperature stress
Authors: Tianqing Huang, Wei Gu, Enhui Liu, Bingqian Wang, Gaochao Wang, Fulin Dong, Fuyuan Guo, Wenlong Jiao, Yanchun Sun, Xiance Wang, Shanwei Li, Gefeng Xu
Journal: Ecotoxicol Environ Saf
PubMed ID: 35901591
Doi: 10.1016/j.ecoenv.2022.113915
Products & Services: Plasmid DNA Preparation   
An immunodetection assay developed using cobra cytotoxin-specific antibodies: Potential diagnostics for cobra envenoming
Authors: Hui Ling Ong, Choo Hock Tan, Louisa Pernee Lee, Sook Mei Khor, Kae Yi Tan
Journal: Toxicon
PubMed ID: 35868411
Doi: 10.1016/j.toxicon.2022.07.010
Products & Services: Catalog Antibody   
A Single Dose of Anti-HBsAg Antibody-Encoding mRNA-LNPs Suppressed HBsAg Expression: a Potential Cure of Chronic Hepatitis B Virus Infection
Authors: Binfan Chen, Yuchen Chen, Jian Li, Chunyu Wang, Wenping Song, Yumei Wen, Jinzhong Lin, Yanling Wu, Tianlei Ying
Journal: MBio
PubMed ID: 35862767
Doi: 10.1128/mbio.01612-22
Products & Services: Catalog Antibody   
Phage defence by deaminase-mediated depletion of deoxynucleotides in bacteria
Authors: Brian Y Hsueh, Geoffrey B Severin, Clinton A Elg, Evan J Waldron, Abhiruchi Kant, Alex J Wessel, John A Dover, Christopher R Rhoades, Benjamin J Ridenhour, Kristin N Parent, Matthew B Neiditch, Janani Ravi, Eva M Top, Christopher M Waters
Journal: Nat Microbiol
PubMed ID: 35817890
Doi: 10.1038/s41564-022-01162-4
Products & Services: Catalog Antibody   
Sequence grammar underlying the unfolding and phase separation of globular proteins
Authors: Kiersten M Ruff, Yoon Hee Choi, Dezerae Cox, Angelique R Ormsby, Yoochan Myung, David B Ascher, Sheena E Radford, Rohit V Pappu, Danny M Hatters
Journal: Mol Cell
PubMed ID: 35853451
Doi: 10.1016/j.molcel.2022.06.024
Products & Services: Custom Vector Construction   
Screening circular RNAs with functional potential using the RfxCas13d/BSJ-gRNA system
Authors: Siqi Li, Hao Wu, Ling-Ling Chen
Journal: Nat Protoc
PubMed ID: 35831613
Doi: 10.1038/s41596-022-00715-5
Products & Services: Custom DNA/RNA Oligos   
SARS-CoV-2 Epitopes following Infection and Vaccination Overlap Known Neutralizing Antibody Sites
Authors: Li Yang, Te Liang, Lane M Pierson, Hongye Wang, Jesse K Fletcher, Shu Wang, Duran Bao, Lili Zhang, Zhen Huang, Wenshu Zheng, Xiaomei Zhang, Heewon Park, Yuwen Li, James E Robinson, Amy K Feehan, Christopher J Lyon, Jing Cao, Lisa A Morici, Chenzhong Li, Chad J Roy, Xiaobo Yu, Tony Hu
Journal: Research (Wash D C)
PubMed ID: 35928300
Doi: 10.34133/2022/9769803
Products & Services: Catalog Peptides   
Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut
Authors: Víctor Taleb, Qinghua Liao, Yoshiki Narimatsu, Ana García-García, Ismael Compañón, Rafael Junqueira Borges, Andrés Manuel González-Ramírez, Francisco Corzana, Henrik Clausen, Carme Rovira, Ramon Hurtado-Guerrero
Journal: Nat Commun
PubMed ID: 35882872
Doi: 10.1038/s41467-022-32021-9
Products & Services: Mutagenesis Services   
Phage Particles of Controlled Length and Genome for Targeted Glioblastoma Imaging and Therapeutic Delivery
Authors: Uyanga Tsedev, Ching-Wei Lin, Gaelen T Hess, Jann N Sarkaria, Fred C Lam, Angela M Belcher
Journal: ACS Nano
PubMed ID: 35830573
Doi: 10.1021/acsnano.1c08720
Products & Services: Plasmid DNA Preparation   
The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency Pathway
Authors: Lindsay C Sidak-Loftis, Kristin L Rosche, Natasha Pence, Jessica K Ujczo, Joanna Hurtado, Elis A Fisk, Alan G Goodman, Susan M Noh, John W Peters, Dana K Shaw
Journal: MBio
PubMed ID: 35862781
Doi: 10.1128/mbio.00703-22
Products & Services: Mammalian Expression   
Conformational landscape of the yeast SAGA complex as revealed by cryo-EM
Authors: Diana Vasyliuk, Joeseph Felt, Ellen D Zhong, Bonnie Berger, Joseph H Davis, Calvin K Yip
Journal: Sci Rep
PubMed ID: 35853968
Doi: 10.1038/s41598-022-16391-0
Protective effects of small heat shock proteins in Daphnia magna against heavy metal exposure
Authors: Muyi Li, Ting Tang, Fengyu Yuan, Yuming Zhang, Fengchao Li, Fengsong Liu
Journal: Sci Total Environ
PubMed ID: 35907523
Doi: 10.1016/j.scitotenv.2022.157565
Development and applications of a TaqMan based quantitative real-time PCR for the rapid detection of Pigeon circovirus (PiCV)
Authors: Babu K Nath, Shubhagata Das, Tridip Das, Jade K Forwood, Shane R Raidal
Journal: J Virol Methods
PubMed ID: 35870671
Doi: 10.1016/j.jviromet.2022.114588
Cholesterol Deprivation Drives DHEA Biosynthesis in Human Adrenals
Authors: Emanuele Pignatti, Emre Murat Altinkilic, Konstantin Bräutigam, Michael Grössl, Aurel Perren, Mihaela Zavolan, Christa E Flück
Journal: Endocrinology
PubMed ID: 35583599
Doi: 10.1210/endocr/bqac076
Products & Services: Plasmid DNA Preparation   
An Engineered λ Phage Enables Enhanced and Strain-Specific Killing of Enterohemorrhagic Escherichia coli
Authors: Menglu Jin, Jingchao Chen, Xueyang Zhao, Guoru Hu, Hailei Wang, Zhi Liu, Wei-Hua Chen
Journal: Microbiol Spectr
PubMed ID: 35876591
Doi: 10.1128/spectrum.01271-22
Products & Services: Gene Synthesis   
Development and Assessment of Herpes Simplex Virus Type 1 (HSV-1) Amplicon Vectors with Sensory Neuron-Selective Promoters
Authors: Charles Joussain, Olivier Le Coz, Andrey Pichugin, Peggy Marconi, Filip Lim, Mariaconcetta Sicurella, Keith Foster, François Giuliano, Alberto L Epstein, Alejandro Aranda Muñoz
Journal: Int J Mol Sci
PubMed ID: 35955608
Doi: 10.3390/ijms23158474
Products & Services: Gene Synthesis   
Impacts of a Zwitterionic Peptide on its Fusion Protein
Authors: Patrick McMullen, Liang Fang, Qi Qiao, Qing Shao, Shaoyi Jiang
Journal: Bioconjug Chem
PubMed ID: 35852436
Doi: 10.1021/acs.bioconjchem.2c00176
Products & Services: Custom DNA/RNA Oligos   
Paraneoplastic Pemphigus Autoantibodies Against C-terminus of Desmoplakin Induced Acantholysis and
Authors: Xue Wang, Rui Wang, Dingfang Bu, Leyi Wang, Yuexin Zhang, Yuan Chang, Chenyang Zhang, Xixue Chen, Xuejun Zhu, Zhi Liu, Mingyue Wang
Journal: Front Immunol
PubMed ID: 35911677
Doi: 10.3389/fimmu.2022.886226
Products & Services: Bacterial Expression   
In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus
Authors: Linda B Oyama, Hamza Olleik, Ana Carolina Nery Teixeira, Matheus M Guidini, James A Pickup, Brandon Yeo Pei Hui, Nicolas Vidal, Alan R Cookson, Hannah Vallin, Toby Wilkinson, Denise M S Bazzolli, Jennifer Richards, Mandy Wootton, Ralf Mikut, Kai Hilpert, Marc Maresca, Josette Perrier, Matthias Hess, Hilario C Mantovani, Narcis Fernandez-Fuentes, Christopher J Creevey, Sharon A Huws
Journal: NPJ Biofilms Microbiomes
PubMed ID: 35835775
Doi: 10.1038/s41522-022-00320-0
Rhesus rotavirus receptor-binding site affects high mobility group box 1 release, altering the pathogenesis of experimental biliary atresia
Authors: Sujit K Mohanty, Bryan Donnelly, Haley Temple, Sarah Mowery, Holly M Poling, Jaroslaw Meller, Astha Malik, Monica McNeal, Greg Tiao
Journal: Hepatol Commun
PubMed ID: 35866580
Doi: 10.1002/hep4.2024
Products & Services: Catalog Peptides   
The transient expression of recombinant proteins in plant cell packs facilitates stable isotope labelling for NMR spectroscopy
Authors: Patrick Opdensteinen, Laura E Sperl, Mariam Mohamadi, Nicole Kündgen-Redding, Franz Hagn, Johannes Felix Buyel
Journal: Plant Biotechnol J
PubMed ID: 35702941
Doi: 10.1111/pbi.13873
The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE mice
Authors: Yishi Shen, Hong-Mei Gu, Lei Zhai, Binxiang Wang, Shucun Qin, Da-Wei Zhang
Journal: Biochim Biophys Acta Mol Cell Biol Lipids
PubMed ID: 35803528
Doi: 10.1016/j.bbalip.2022.159196
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Antitumor efficacy of MUC1-derived variable epitope library treatments in a mouse model of breast cancer
Authors: Josué Odales, Rodolfo Servín-Blanco, Fernando Martínez-Cortés, Jesus Guzman Valle, Allan Noé Domínguez-Romero, Goar Gevorkian, Karen Manoutcharian
Journal: Vaccine
PubMed ID: 35788294
Doi: 10.1016/j.vaccine.2022.06.062
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O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1
Authors: Qiang Zhu, Hong Zhou, Liming Wu, Zhenyuan Lai, Didi Geng, Weiwei Yang, Jie Zhang, Zhiya Fan, Weijie Qin, Yong Wang, Ruhong Zhou, Wen Yi
Journal: Nat Chem Biol
PubMed ID: 35879546
Doi: 10.1038/s41589-022-01085-5
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Reprogramming of Human B Cells from Secreting IgG to IgM by Genome Editing
Authors: Guigao Lin, Kuo Zhang, Yanxi Han, Rongxue Peng, Jiawei Zhang, Dandan Li, Jinming Li
Journal: CRISPR J
PubMed ID: 35900273
Doi: 10.1089/crispr.2021.0093
Products & Services: Custom Vector Construction   
Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis
Authors: Nikola Kenjić, Kathleen M Meneely, Daniel J Wherritt, Melissa C Denler, Timothy A Jackson, Graham R Moran, Audrey L Lamb
Journal: J Am Chem Soc
PubMed ID: 35802469
Doi: 10.1021/jacs.2c03376
Products & Services: Gene Synthesis   
Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice
Authors: Yuning Liu, Hong Xing, Alexis F Ernst, Canna Liu, Christian Maugee, Fumiaki Yokoi, Madepalli Lakshmana, Yuqing Li
Journal: Mol Cell Neurosci
PubMed ID: 35843530
Doi: 10.1016/j.mcn.2022.103756
Products & Services: Monoclonal Antibody Services   
Tumor-Localized Administration of α-GalCer to Recruit Invariant Natural Killer T Cells and Enhance Their Antitumor Activity against Solid Tumors
Authors: Yan-Ruide Li, Yang Zhou, Matthew Wilson, Adam Kramer, Ryan Hon, Yichen Zhu, Ying Fang, Lili Yang
Journal: Int J Mol Sci
PubMed ID: 35886891
Doi: 10.3390/ijms23147547
Products & Services: Recombinant Proteins   
Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge
Authors: Shanna S Leventhal, Kimberly Meade-White, Deepashri Rao, Elaine Haddock, Jacqueline Leung, Dana Scott, Jacob Archer, Samantha Randall, Jesse H Erasmus, Heinz Feldmann, David W Hawman
Journal: EBioMedicine
PubMed ID: 35907368
Doi: 10.1016/j.ebiom.2022.104188
Products & Services: Peptide Synthesis   
Development of Melioidosis Subunit Vaccines Using an Enzymatically Inactive Burkholderia pseudomallei AhpC
Authors: Lindsey K Schmidt, Caitlyn E Orne, Teresa L Shaffer, Shane M Wilson, Nittaya Khakhum, Alfredo G Torres, Paul J Brett, Mary N Burtnick
Journal: Infect Immun
PubMed ID: 35862715
Doi: 10.1128/iai.00222-22
The Patterning and Proportion of Charged Residues in the Arginine-Rich Mixed-Charge Domain Determine the Membrane-Less Organelle Targeted by the Protein
Authors: Tamami Miyagi, Rio Yamazaki, Koji Ueda, Satoshi Narumi, Yuhei Hayamizu, Hiroshi Uji-I, Masahiko Kuroda, Kohsuke Kanekura
Journal: Int J Mol Sci
PubMed ID: 35887012
Doi: 10.3390/ijms23147658
Products & Services: Bacterial Expression   
Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos
Authors: Fanye Meng, Chenxi Xu, Kwang-Su Park, H Ümit Kaniskan, Gang Greg Wang, Jian Jin
Journal: J Med Chem
PubMed ID: 35895319
Doi: 10.1021/acs.jmedchem.2c00807
Products & Services: Plasmid DNA Preparation   
Development and characterization of an inducible assay system to measure Zika virus capsid interactions
Authors: Jieshi Yu, Chen Huang, Zhao Wang, Radhey S Kaushik, Zizhang Sheng, Feng Li, Dan Wang
Journal: J Med Virol
PubMed ID: 35822280
Doi: 10.1002/jmv.27991
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SARS-CoV-2 Omicron escapes mRNA vaccine booster-induced antibody neutralisation in patients with autoimmune rheumatic diseases: an observational cohort study
Authors: Woo-Joong Kim, Seong-Ho Choi, Ji Young Park, Jung Soo Song, Jin-Won Chung, Sang Tae Choi
Journal: Ann Rheum Dis
PubMed ID: 35878999
Doi: 10.1136/ard-2022-222689
Bacteria deplete deoxynucleotides to defend against bacteriophage infection
Authors: Nitzan Tal, Adi Millman, Avigail Stokar-Avihail, Taya Fedorenko, Azita Leavitt, Sarah Melamed, Erez Yirmiya, Carmel Avraham, Alexander Brandis, Tevie Mehlman, Gil Amitai, Rotem Sorek
Journal: Nat Microbiol
PubMed ID: 35817891
Doi: 10.1038/s41564-022-01158-0
Products & Services: PCR Cloning and Subcloning   
RG203KR Mutations in SARS-CoV-2 Nucleocapsid: Assessing the Impact Using a Virus-Like Particle Model System
Authors: Harsha Raheja, Soma Das, Anindita Banerjee, Dikshaya P, Deepika C, Debanjan Mukhopadhyay, Subbaraya G Ramachandra, Saumitra Das
Journal: Microbiol Spectr
PubMed ID: 35862952
Doi: 10.1128/spectrum.00781-22
Products & Services: Gene Synthesis   
Development of an in-house quantitative ELISA for the evaluation of different Covid-19 vaccines in humans
Authors: Mariem Gdoura, Fatma Ben Ghaloum, Meriem Ben Hamida, Wafa Chamsa, Henda Triki, Chokri Bahloul
Journal: Sci Rep
PubMed ID: 35788676
Doi: 10.1038/s41598-022-15378-1
In situ architecture of the lipid transport protein VPS13C at ER-lysosome membrane contacts
Authors: Shujun Cai, Yumei Wu, Andrés Guillén-Samander, William Hancock-Cerutti, Jun Liu, Pietro De Camilli
Journal: Proc Natl Acad Sci U S A
PubMed ID: 35858323
Doi: 10.1073/pnas.2203769119
Products & Services: Mutant Libraries   
Immunogenicity of the third and fourth BNT162b2 mRNA COVID-19 boosters and factors associated with immune response in patients with SLE and rheumatoid arthritis
Authors: Theerada Assawasaksakul, Seelwan Sathitratanacheewin, Preeyaporn Vichaiwattana, Nasamon Wanlapakorn, Yong Poovorawan, Yingyos Avihingsanon, Nawaporn Assawasaksakul, Wonngarm Kittanamongkolchai
Journal: Lupus Sci Med
PubMed ID: 35902168
Doi: 10.1136/lupus-2022-000726
HOXB5-activated ANGPT2 promotes the proliferation, migration, invasion and angiogenic effect of esophageal cancer cells via activating ERK/AKT signaling pathway
Authors: Jing Li, Shanshan Gao
Journal: Exp Ther Med
PubMed ID: 35949323
Doi: 10.3892/etm.2022.11522
Products & Services: Gene Synthesis   
The Relative Positioning of B and T Cell Epitopes Drives Immunodominance
Authors: Riccardo Biavasco, Marco De Giovanni
Journal: Vaccines (Basel)
PubMed ID: 36016115
Doi: 10.3390/vaccines10081227
Products & Services: Mammalian Expression   
Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation
Authors: Charline Mary, Mona Hoseini Soflaee, Rushendhiran Kesavan, Muriel Gelin, Harrison Brown, G Zacharias, Thomas P Mathews, Andrew Lemoff, Corinne Lionne, Gilles Labesse, Gerta Hoxhaj
Journal: Mol Cell
PubMed ID: 35868311
Doi: 10.1016/j.molcel.2022.06.026
Products & Services: Mammalian Expression   
A Novel Cre/lox71-Based System for Inducible Expression of Recombinant Proteins and Genome Editing
Authors: Maxim Karagyaur, Daniyar Dyikanov, Pyotr Tyurin-Kuzmin, Stalik Dzhauari, Mariya Skryabina, Maksim Vigovskiy, Alexandra Primak, Natalia Kalinina, Vsevolod Tkachuk
Journal: Cells
PubMed ID: 35883584
Doi: 10.3390/cells11142141
Products & Services: Plasmid DNA Preparation   
ArsR Family Regulator MSMEG_6762 Mediates the Programmed Cell Death by Regulating the Expression of HNH Nuclease in Mycobacteria
Authors: Xiangke Duan, Xue Huang, Junqi Xu, Xue Li, Jingjing Niu, Xiaoli Du, Xiaoyu Wang, Jiang Li, Michael Kelly, Jiaohan Guo, Ke Zhang, Yu Huang, Biao Kan, Jianping Xie
Journal: Microorganisms
PubMed ID: 36013953
Doi: 10.3390/microorganisms10081535
Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis
Authors: Yize Liu, Guanzhen Qiu, Yinzhou Luo, Shanshan Li, Yeqiu Xu, Yuanzhuang Zhang, Jiayuan Hu, Peifeng Li, Hai Pan, Yong Wang
Journal: Exp Mol Med
PubMed ID: 35879346
Doi: 10.1038/s12276-022-00806-z
Products & Services: Mutant Libraries   
Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents
Authors: Jiyun Zhu, Linfeng Li, Aleksandra Drelich, Bala C Chenna, Drake M Mellott, Zane W Taylor, Vivian Tat, Christopher Z Garcia, Ardala Katzfuss, Chien-Te K Tseng, Thomas D Meek
Journal: Front Chem
PubMed ID: 35860632
Doi: 10.3389/fchem.2022.867928
Products & Services: Gene Synthesis   
Comprehensive Evaluation and Comparison of Machine Learning Methods in QSAR Modeling of Antioxidant Tripeptides
Authors: Zhenjiao Du, Donghai Wang, Yonghui Li
Journal: ACS Omega
PubMed ID: 35910147
Doi: 10.1021/acsomega.2c03062
Products & Services: Peptide Synthesis   
Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes
Authors: Jean Mukherjee, Celinia A Ondeck, Jacqueline M Tremblay, Jacob Archer, Michelle Debatis, Alexa Foss, Junya Awata, Jesse H Erasmus, Patrick M McNutt, Charles B Shoemaker
Journal: Sci Rep
PubMed ID: 35803998
Doi: 10.1038/s41598-022-15876-2
Products & Services: Gene Synthesis   
Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures
Authors: Marlen Kruse, Basma Altattan, Eva-Maria Laux, Nico Grasse, Lars Heinig, Christin Möser, David M Smith, Ralph Hölzel
Journal: Sci Rep
PubMed ID: 35896714
Doi: 10.1038/s41598-022-16914-9
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HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations
Authors: Yong Du, Yongfeng Chen, Yuxia Wang, Jinju Chen, Xiaorong Lu, Li Zhang, Yan Li, Zhaofu Wang, Guozhong Ye, George Zhang
Journal: Mol Cancer Ther
PubMed ID: 35499406
Doi: 10.1158/1535-7163.MCT-21-0835
Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis
Authors: Zachary Armstrong, Richard W Meek, Liang Wu, James N Blaza, Gideon J Davies
Journal: Structure
PubMed ID: 35907402
Doi: 10.1016/j.str.2022.07.001
Products & Services: Mutant Libraries   
Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis
Authors: Wenli Liu, Nataliya Östberg, Mustafa Yalcinkaya, Huijuan Dou, Kaori Endo-Umeda, Yang Tang, Xintong Hou, Tong Xiao, Trevor P Fidler, Sandra Abramowicz, Yong-Guang Yang, Oliver Soehnlein, Alan R Tall, Nan Wang
Journal: J Clin Invest
PubMed ID: 35587375
Doi: 10.1172/JCI155724
Products & Services: Recombinant Proteins   
Construction of a Novel Clinical Stage-Related Gene Signature for Predicting Outcome and Immune Response in Hepatocellular Carcinoma
Authors: Liu Yang, Long-Fei Zeng, Guo-Qing Hong, Qing Luo, Xing Lai
Journal: J Immunol Res
PubMed ID: 35865652
Doi: 10.1155/2022/6535009
Products & Services: Custom DNA/RNA Oligos   
Silencing lncRNA 93358 Inhibits the Apoptosis of Myocardial Cells in Myocardial Infarction Rats by Inducing the Expression of SLC8A1
Authors: Jiumei Cai, Xiaoping Wang, Wei Liao, Yiming Zhong, Lingling Chen, Zhiwei Zhang
Journal: Biomed Res Int
PubMed ID: 35845941
Doi: 10.1155/2022/1138709
Products & Services: Gene Synthesis   
Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism
Authors: Yong-Gang Chang, Christopher J Lupton, Charles Bayly-Jones, Alastair C Keen, Laura D'Andrea, Christina M Lucato, Joel R Steele, Hari Venugopal, Ralf B Schittenhelm, James C Whisstock, Michelle L Halls, Andrew M Ellisdon
Journal: Nat Struct Mol Biol
PubMed ID: 35864164
Doi: 10.1038/s41594-022-00804-9
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Diminished T-cell immune responses to SARS-CoV-2 omicron variant after BNT162b2 vaccination
Authors: Stanley C Jordan, Bong-Ha Shin, Edgar Rodriguez, Ashley Vo, Ruan Zhang
Journal: Immunol Lett
PubMed ID: 35843362
Doi: 10.1016/j.imlet.2022.07.004
Products & Services: Catalog Antibody   
Intranasal administration of a live-attenuated recombinant newcastle disease virus expressing the SARS-CoV-2 Spike protein induces high neutralizing antibody levels and protects from experimental challenge infection in hamsters
Authors: Rik L de Swart, Olav S de Leeuw, Nadia Oreshkova, Nora M Gerhards, Irina C Albulescu, Sandra Vreman, José L Gonzales, Riks Maas, Frank J M van Kuppeveld, Peter Soema, Berend-Jan Bosch, Ben P H Peeters
Journal: Vaccine
PubMed ID: 35820941
Doi: 10.1016/j.vaccine.2022.07.005
Products & Services: Mammalian Expression   
Large-scale application of free energy perturbation calculations for antibody design
Authors: Fangqiang Zhu, Feliza A Bourguet, William F D Bennett, Edmond Y Lau, Kathryn T Arrildt, Brent W Segelke, Adam T Zemla, Thomas A Desautels, Daniel M Faissol
Journal: Sci Rep
PubMed ID: 35864134
Doi: 10.1038/s41598-022-14443-z
Products & Services: Catalog Antibody   
Translating a Thin-Film Rehydration Method to Microfluidics for the Preparation of a SARS-CoV-2 DNA Vaccine: When Manufacturing Method Matters
Authors: Allegra Peletta, Eakachai Prompetchara, Kittipan Tharakhet, Papatsara Kaewpang, Supranee Buranapraditkun, Nongnaphat Yostrerat, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Jonathan Avaro, Leonard Krupnik, Antonia Neels, Kiat Ruxrungtham, Chutitorn Ketloy, Gerrit Borchard
Journal: Pharmaceutics
PubMed ID: 35890321
Doi: 10.3390/pharmaceutics14071427
Products & Services: Mammalian Expression   
From functional genomics of vero cells to CRISPR-based genomic deletion for improved viral production rates
Authors: Marie-Angélique Sène, Yu Xia, Amine A Kamen
Journal: Biotechnol Bioeng
PubMed ID: 35869699
Doi: 10.1002/bit.28190
Products & Services: Molecular Biology Tools   
Interaction of Liberibacter Solanacearum with Host Psyllid Vitellogenin and Its Association with Autophagy
Authors: Poulami Sarkar, Murad Ghanim
Journal: Microbiol Spectr
PubMed ID: 35863005
Doi: 10.1128/spectrum.01577-22
Ligand-induced transmembrane conformational coupling in monomeric EGFR
Authors: Shwetha Srinivasan, Raju Regmi, Xingcheng Lin, Courtney A Dreyer, Xuyan Chen, Steven D Quinn, Wei He, Matthew A Coleman, Kermit L Carraway, Bin Zhang, Gabriela S Schlau-Cohen
Journal: Nat Commun
PubMed ID: 35794108
Doi: 10.1038/s41467-022-31299-z
Products & Services: Mutagenesis Services   
NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections
Authors: Philippe Rascle, Cyril Planchais, Béatrice Jacquelin, Marie Lazzerini, Vanessa Contreras, Caroline Passaes, Asier Saez-Cirion, Hugo Mouquet, Nicolas Huot, Michaela Müller-Trutwin
Journal: Commun Biol
PubMed ID: 35798936
Doi: 10.1038/s42003-022-03619-y
Products & Services: Custom Vector Construction   
Structural, functional, and immunogenicity implications of F9 gene recoding
Authors: Upendra K Katneni, Aikaterini Alexaki, Ryan C Hunt, Nobuko Hamasaki-Katagiri, Gaya K Hettiarachchi, Jacob M Kames, Joseph R McGill, David D Holcomb, John C Athey, Brian Lin, Leonid A Parunov, Tal Kafri, Qi Lu, Robert Peters, Mikhail V Ovanesov, Darón I Freedberg, Haim Bar, Anton A Komar, Zuben E Sauna, Chava Kimchi-Sarfaty
Journal: Blood Adv
PubMed ID: 35413099
Doi: 10.1182/bloodadvances.2022007094
Products & Services: Plasmid DNA Preparation   
Neutralizing antibody responses against SARS-CoV-2 in patients with plasma cell disorders who are on active treatment after two doses of mRNA vaccination
Authors: Al-Ola Abdallah, Zahra Mahmoudjafari, Tahani Atieh, Nausheen Ahmed, Wei Cui, Leyla Shune, Meera Mohan, Joseph McGuirk, Cassie Remker, Margaret Foss, Ellie Karloff, Heather Fitch, Shebli Atrash
Journal: Eur J Haematol
PubMed ID: 35810359
Doi: 10.1111/ejh.13826
Highly Effective Markerless Genetic Manipulation of Using a Mutated PheS-Based Counterselectable Marker
Authors: Guangjuan Gao, Dong Wei, Gang Li, Ping Chen, Liujun Wu, Siguo Liu, Yueling Zhang
Journal: Front Microbiol
PubMed ID: 35910605
Doi: 10.3389/fmicb.2022.947821
Products & Services: Peptide Synthesis   
CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7
Authors: Yong Zi Tan, Yazan M Abbas, Jing Ze Wu, Di Wu, Kristine A Keon, Geoffrey G Hesketh, Stephanie A Bueler, Anne-Claude Gingras, Carol V Robinson, Sergio Grinstein, John L Rubinstein
Journal: Life Sci Alliance
PubMed ID: 35794005
Doi: 10.26508/lsa.202201527
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