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Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains

Authors: Lining Lu, Xiaoguo Zhai, Xiaolong Li, Shuansuo Wang, Lijun Zhang, Luyang Wang, Xi Jin, Lujun Liang, Zhiheng Deng, Zichen Li, Yanfeng Wang, Xiangdong Fu, Honggang Hu, Jiawei Wang, Ziqing Mei, Zhengguo He, Feng Wang

Journal: Nat Commun

PubMed ID: 35945250

Doi: 10.1038/s41467-022-32364-3

Products & Services: Codon Optimization

ChAdOx1 nCoV-19 (AZD1222) or nCoV-19-Beta (AZD2816) protect Syrian hamsters against Beta Delta and Omicron variants

Authors: Neeltje van Doremalen, Jonathan E Schulz, Danielle R Adney, Taylor A Saturday, Robert J Fischer, Claude Kwe Yinda, Nazia Thakur, Joseph Newman, Marta Ulaszewska, Sandra Belij-Rammerstorfer, Greg Saturday, Alexandra J Spencer, Dalan Bailey, Colin A Russell, Sarah C Gilbert, Teresa Lambe, Vincent J Munster

Journal: Nat Commun

PubMed ID: 35941149

Doi: 10.1038/s41467-022-32248-6

Products & Services: Catalog Antibody

Generation of Human Domain Antibody Fragments as Potential Insecticidal Agents against by Cadherin-Based Screening

Authors: Xiaodan Hu, Xiao Zhang, Yuan Liu, Meijing Gao, Manman Lin, Yajing Xie, Qing Zhu, Chongxin Xu, Xianjin Liu, Dalene Vosloo, Ofentse Jacob Pooe

Journal: J Agric Food Chem

PubMed ID: 35944165

Doi: 10.1021/acs.jafc.2c02000

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Dihydropyridine-derived calcium channel blocker as a promising anti-Hantaviral entry inhibitor

Authors: Bin Wang , Jiawei Pei, Hui Zhang , Jia Li , Yamei Dang , He Liu , Yuan Wang , Liang Zhang , Libin Qi , Yuewu Yang , Linfeng Cheng , Yangchao Dong , Airong Qian , Zhikai Xu , Yingfeng Lei , Fanglin Zhang , Wei Ye

Journal: Front Pharmacol .

PubMed ID: 36105208

Doi: 10.3389/fphar.2022.940178.

Products & Services: Gene Synthesis

Reduced sister chromatid cohesion acts as a tumor penetrance modifier

Authors: Jun Wang, Holly R Thomas, Yu Chen, Stefanie M Percival, Stephanie C Waldrep, Ryne C Ramaker, Robert G Thompson, Sara J Cooper, Zechen Chong, John M Parant

Journal: PLoS Genet

PubMed ID: 35994499

Doi: 10.1371/journal.pgen.1010341

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Novel Hits for N-Myristoyltransferase Inhibition Discovered by Docking-Based Screening

Authors: Danislav S Spassov, Mariyana Atanasova, Irini Doytchinova

Journal: Molecules

PubMed ID: 36080246

Doi: 10.3390/molecules27175478

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An antibody from single human V-rearranging mouse neutralizes all SARS-CoV-2 variants through BA5 by inhibiting membrane fusion

Authors: Sai Luo, Jun Zhang, Alex J B Kreutzberger, Amanda Eaton, Robert J Edwards, Changbin Jing, Hai-Qiang Dai, Gregory D Sempowski, Kenneth Cronin, Robert Parks, Adam Yongxin Ye, Katayoun Mansouri, Maggie Barr, Novalia Pishesha, Aimee Chapdelaine Williams, Lucas Vieira Francisco, Anand Saminathan, Hanqin Peng, Himanshu Batra, Lorenza Bellusci, Surender Khurana, S Munir Alam, David C Montefiori, Kevin O Saunders, Ming Tian, Hidde Ploegh, Tom Kirchhausen, Bing Chen, Barton F Haynes, Frederick W Alt

Journal: Sci Immunol

PubMed ID: 35951767

Doi: 10.1126/sciimmunol.add5446

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Structure and engineering of the minimal type VI CRISPR-Cas13bt3

Authors: Ryoya Nakagawa, Soumya Kannan, Han Altae-Tran, Satoru N Takeda, Atsuhiro Tomita, Hisato Hirano, Tsukasa Kusakizako, Tomohiro Nishizawa, Keitaro Yamashita, Feng Zhang, Hiroshi Nishimasu, Osamu Nureki

Journal: Mol Cell

PubMed ID: 36027912

Doi: 10.1016/j.molcel.2022.08.001

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Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 Protease

Authors: Annelies Stevaert, Ria Van Berwaer, Cato Mestdagh, Julie Vandeput, Els Vanstreels, Valerie Raeymaekers, Manon Laporte, Lieve Naesens

Journal: MBio

PubMed ID: 35913162

Doi: 10.1128/mbio.01376-22

Products & Services: Proteins, Expression, Isolation and Analysis

TCR extracellular domain genetically linked to CD28, 2B4/41BB and DAP10/CD3ζ -engineered NK cells mediates antitumor effects

Authors: Shance Li, Chaoting Zhang, Luyan Shen, Xia Teng, Yefei Xiao, Bentong Yu, Zheming Lu

Journal: Cancer Immunol Immunother

PubMed ID: 35988132

Doi: 10.1007/s00262-022-03275-5

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SARS-CoV-2 in a Mink Farm in Italy: Case Description, Molecular and Serological Diagnosis by Comparing Different Tests

Authors: Ana Moreno, Davide Lelli, Tiziana Trogu, Antonio Lavazza, Ilaria Barbieri, MariaBeatrice Boniotti, Giulia Pezzoni, Cristian Salogni, Stefano Giovannini, Giovanni Alborali, Silvia Bellini, Massimo Boldini, Marco Farioli, Luigi Ruocco, Olivia Bessi, Andrea Maroni Ponti, Ilaria Di Bartolo, Luca De Sabato, Gabriele Vaccari, Gabriele Belli, Alberto Margutti, Maurilio Giorgi

Journal: Viruses

PubMed ID: 36016360

Doi: 10.3390/v14081738

Products & Services: Recombinant Proteins

Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody

Authors: Mithu Baidya, Madhu Chaturvedi, Hemlata Dwivedi-Agnihotri, Ashutosh Ranjan, Dominic Devost, Yoon Namkung, Tomasz Maciej Stepniewski, Shubhi Pandey, Minakshi Baruah, Bhanupriya Panigrahi, Parishmita Sarma, Manish K Yadav, Jagannath Maharana, Ramanuj Banerjee, Kouki Kawakami, Asuka Inoue, Jana Selent, Stéphane A Laporte, Terence E Hébert, Arun K Shukla

Journal: Nat Commun

PubMed ID: 35941121

Doi: 10.1038/s41467-022-32386-x

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Immunoprophylaxis using polypeptide chimera vaccines plus adjuvant system promote Th1 response controlling the spleen parasitism in hamster model of visceral leishmaniasis

Authors: Miriã Rodrigues Gusmão, Thaís Lopes Valentim Di Paschoali Ostolin, Lívia Mendes Carvalho, Ana Flávia Pereira Costa, Gabriel José Lucas Moreira, Jamille Mirelle de Oliveira Cardoso, Rodrigo Dian de Oliveira Aguiar-Soares, Alexandre Barbosa Reis, Rory Cristiane Fortes de Brito, Bruno Mendes Roatt

Journal: Vaccine

PubMed ID: 35963820

Doi: 10.1016/j.vaccine.2022.08.005

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Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation

Authors: Jun-Yi Liu, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Shigeharu Yoshida, Kosuke Ogata, Yasushi Ishihama, Yuzuru Imai, Nobutaka Hattori

Journal: Hum Mol Genet

PubMed ID: 35313349

Doi: 10.1093/hmg/ddac064

Products & Services: Mutagenesis Services

Neuroprotection of Bone Marrow-Derived Mesenchymal Stem Cell-Derived Extracellular Vesicle-Enclosed miR-410 Correlates with HDAC4 Knockdown in Hypoxic-Ischemic Brain Damage

Authors: Mingqi Shen, Rongxiu Zheng, Xuan Kan

Journal: Neurochem Res

PubMed ID: 36028735

Doi: 10.1007/s11064-022-03670-5

Products & Services: Mutant Libraries

Pathway elucidation of bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiae

Authors: Chaojing Li, Xing Yan, Zhenzhen Xu, Yan Wang, Xiao Shen, Lei Zhang, Zhihua Zhou, Pingping Wang

Journal: Commun Biol

PubMed ID: 35918414

Doi: 10.1038/s42003-022-03740-y

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Identification of the extracellular metallo-endopeptidases ADAM and ADAMTS in the yellow fever mosquito Aedes aegypti

Authors: Christie S Herd, Xiudao Yu, Yingjun Cui, Alexander W E Franz

Journal: Insect Biochem Mol Biol

PubMed ID: 35932972

Doi: 10.1016/j.ibmb.2022.103815

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Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses

Authors: Norbert Pardi, Juan Manuel Carreño, George O'Dell, Jessica Tan, Csaba Bajusz, Hiromi Muramatsu, Willemijn Rijnink, Shirin Strohmeier, Madhumathi Loganathan, Dominika Bielak, Molly M H Sung, Ying K Tam, Florian Krammer, Meagan McMahon

Journal: Nat Commun

PubMed ID: 35945226

Doi: 10.1038/s41467-022-32149-8

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Second-Generation SuptoxR Strains for High-Level Recombinant Membrane Protein Production

Authors: Eleni Vasilopoulou, Artemis Giannakopoulou, Charalampos Kapsalis, Myrsini Michou, Aristeidis Michoglou-Sergiou, Fragiskos N Kolisis, Georgios Skretas

Journal: ACS Synth Biol

PubMed ID: 35922033

Doi: 10.1021/acssynbio.1c00598

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Identification, molecular and biochemical characterization of a novel thermoactive and thermostable glucoamylase from Thermoanaerobacter ethanolicus

Authors: Natael M Wayllace, Nicolas Hedín, María V Busi, Diego F Gomez-Casati

Journal: Biotechnol Lett

PubMed ID: 35997915

Doi: 10.1007/s10529-022-03296-1

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Water-organizing motif continuity is critical for potent ice nucleation protein activity

Authors: Jordan Forbes, Akalabya Bissoyi, Lukas Eickhoff, Naama Reicher, Thomas Hansen, Christopher G Bon, Virginia K Walker, Thomas Koop, Yinon Rudich, Ido Braslavsky, Peter L Davies

Journal: Nat Commun

PubMed ID: 36028506

Doi: 10.1038/s41467-022-32469-9

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TROP2 Down-regulated DSG2 to Promote Gastric Cancer Cell Invasion and Migration by EGFR/AKT and DSG2/PG/β-Catenin Pathways

Authors: Tingting Yang, Lizhou Jia, Susu Bian, Xinxia Chang, Qian Zhang, Qi Tang, Jing Zhu, Zhiping Yang, Zhenqing Feng

Journal: Curr Cancer Drug Targets

PubMed ID: 35392784

Doi: 10.2174/1568009622666220407111013

Products & Services: Proteins, Expression, Isolation and Analysis

CircKPNB1 mediates a positive feedback loop and promotes the malignant phenotypes of GSCs via TNF-α/NF-κB signaling

Authors: Yang Jiang, Junshuang Zhao, Yingliang Liu, Juntao Hu, Liang Gao, Hui Wang, Daming Cui

Journal: Cell Death Dis

PubMed ID: 35945192

Doi: 10.1038/s41419-022-05149-1

Products & Services: Proteins, Expression, Isolation and Analysis

A porcine reproductive and respiratory syndrome virus (PRRSV)-specific IgM as a novel adjuvant for an inactivated PRRSV vaccine improves protection efficiency and enhances cell-mediated immunity against heterologous PRRSV challenge

Authors: Rui Chen, Bing Liu, Xiangmei Zhang, Mengmeng Qin, Jianhui Dong, Guoqian Gu, Chunyan Wu, Jingyu Wang, Yuchen Nan

Journal: Vet Res

PubMed ID: 35986391

Doi: 10.1186/s13567-022-01082-5

Products & Services: Proteins, Expression, Isolation and Analysis

Metal Ion Periplasmic-Binding Protein YfeA of Induces the Secretion of Pro-Inflammatory Cytokines of Macrophages via MAPK and NF-κB Signaling through TLR2 and TLR4

Authors: Zhen Yang, Xinwei Tang, Kang Wang, Ke Dai, Yung-Fu Chang, Senyan Du, Qin Zhao, Xiaobo Huang, Rui Wu, Qigui Yan, Sanjie Cao, Yiping Wen

Journal: Int J Mol Sci

PubMed ID: 36077023

Doi: 10.3390/ijms23179627

Products & Services: Proteins, Expression, Isolation and Analysis

GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis

Authors: Xiaoni Shi, Jing Wang, Xinxin Zhang, Shaoqi Yang, Wei Luo, Sha Wang, Jie Huang, Mengling Chen, Yusi Cheng, Jie Chao

Journal: Cell Biosci

PubMed ID: 35933397

Doi: 10.1186/s13578-022-00860-0

Products & Services: Recombinant Antibody Expression

Detergent-Free Isolation of Membrane Proteins and Strategies to Study Them in a Near-Native Membrane Environment

Authors: Bankala Krishnarjuna, Ayyalusamy Ramamoorthy

Journal: Biomolecules

PubMed ID: 36008970

Doi: 10.3390/biom12081076

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Programmable DARPin-based receptors for the detection of thrombotic markers

Authors: Tobias Strittmatter, Yidan Wang, Adrian Bertschi, Leo Scheller, Patrick C Freitag, Preetam Guha Ray, Pascal Stuecheli, Jonas V Schaefer, Thomas Reinberg, Dimitrios Tsakiris, Andreas Plückthun, Haifeng Ye, Martin Fussenegger

Journal: Nat Chem Biol

PubMed ID: 35941237

Doi: 10.1038/s41589-022-01095-3

Products & Services: Plasmid DNA Preparation

Crystal Structure of Human CD47 in Complex with Engineered SIRPαD1(N80A)

Authors: Jifeng Yu, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Wei Zhang, Li Zhang, Gui Zhao, Xiaoping Tu, Liang Peng, Sijin Liu, Xing Bai, Yongping Song, Zhongxing Jiang, Ruliang Zhang, Wenzhi Tian

Journal: Molecules

PubMed ID: 36080360

Doi: 10.3390/molecules27175574

Products & Services: PCR Cloning and Subcloning

Two independent modes of kidney stone suppression achieved by AIM/CD5L and KIM-1

Authors: Kyohei Matsuura, Natsumi Maehara, Aika Hirota, Ayaka Eguchi, Keisuke Yasuda, Kaori Taniguchi, Akemi Nishijima, Nobuyuki Matsuhashi, Yoshiyuki Shiga, Rumi Ishii, Yasuhiro Iguchi, Kazunari Tanabe, Satoko Arai, Toru Miyazaki

Journal: Commun Biol

PubMed ID: 35922481

Doi: 10.1038/s42003-022-03750-w

Products & Services: Proteins, Expression, Isolation and Analysis

Permissive omicron breakthrough infections in individuals with binding or neutralizing antibodies to ancestral SARS-CoV-2

Authors: Erin Williams, Jordan Colson, Ranjini Valiathan, Juan Manuel Carreño, Florian Krammer, Michael Hoffer, Suresh Pallikkuth, Savita Pahwa, David Andrews

Journal: Vaccine

PubMed ID: 36088193

Doi: 10.1016/j.vaccine.2022.08.058

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Regioselectivity in inhibition of peptide deformylase from Haemophilus influenzae by 4- vs 5-azaindole hydroxamic acid derivatives: Biochemical, structural and antimicrobial studies

Authors: Bharati Reddi, Chandan Kishor, Aruna Jangam, Sandeepchowdary Bala, Uma Rajeswari Batchu, Rambabu Gundla, Anthony Addlagatta

Journal: Bioorg Chem

PubMed ID: 36049321

Doi: 10.1016/j.bioorg.2022.106095

Products & Services: PCR Cloning and Subcloning

Off-the-shelf third-party HSC-engineered iNKT cells for ameliorating GvHD while preserving GvL effect in the treatment of blood cancers

Authors: Yan-Ruide Li, Samuel Zeng, Zachary Spencer Dunn, Yang Zhou, Zhe Li, Jiaji Yu, Yu-Chen Wang, Josh Ku, Noah Cook, Adam Kramer, Lili Yang

Journal: iScience

PubMed ID: 36034226

Doi: 10.1016/j.isci.2022.104859

Products & Services: Proteins, Expression, Isolation and Analysis

PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer

Authors: Shoshana Sedley, Jeetendra Kumar Nag, Tatyana Rudina, Rachel Bar-Shavit

Journal: Int J Mol Sci

PubMed ID: 35955891

Doi: 10.3390/ijms23158758

Products & Services: Plasmid DNA Preparation

High-level de novo biosynthesis of cordycepin by systems metabolic engineering in Yarrowia lipolytica

Authors: Xi-Yu Duan, Yun Tian, Ze-Qi Song, Li-Ping Song, Wen-Bo Lin, Chong Wang, Hui Yang, Xiang-Yang Lu, Xiao-Jun Ji, Hu-Hu Liu

Journal: Bioresour Technol

PubMed ID: 36041680

Doi: 10.1016/j.biortech.2022.127862

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Reduced Immune Response to Inactivated Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine in a Cohort of Immunocompromised Patients in Chile

Authors: M Elvira Balcells, Nicole Le Corre, Josefina Durán, María Elena Ceballos, Cecilia Vizcaya, Sebastián Mondaca, Martín Dib, Ricardo Rabagliati, Mauricio Sarmiento, Paula I Burgos, Manuel Espinoza, Marcela Ferrés, Constanza Martinez-Valdebenito, Cinthya Ruiz-Tagle, Catalina Ortiz, Patricio Ross, Sigall Budnik, Sandra Solari, María de Los Ángeles Vizcaya, Hanns Lembach, Roslye Berrios-Rojas, Felipe Melo-González, Mariana Ríos, Alexis M Kalergis, Susan M Bueno, Bruno Nervi

Journal: Clin Infect Dis

PubMed ID: 35255140

Doi: 10.1093/cid/ciac167

Products & Services: Recombinant Proteins

Influences of miR-378a-3p on the Pathogenesis of Allergic Rhinitis via GzmB-Mediated Inflammatory Reaction

Authors: Xuping Wang, Haiqing Zhang, Long Du, Lian Zhang

Journal: Evid Based Complement Alternat Med

PubMed ID: 36072399

Doi: 10.1155/2022/5926834

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Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells

Authors: Yahui Wang, Ethan Stancliffe, Ronald Fowle-Grider, Rencheng Wang, Cheng Wang, Michaela Schwaiger-Haber, Leah P Shriver, Gary J Patti

Journal: Mol Cell

PubMed ID: 35973426

Doi: 10.1016/j.molcel.2022.07.007

Products & Services: Proteins, Expression, Isolation and Analysis

Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2

Authors: Jun Lan, Peng Chen, Weiming Liu, Wenlin Ren, Linqi Zhang, Qiang Ding, Qi Zhang, Xinquan Wang, Jiwan Ge

Journal: Structure

PubMed ID: 35917815

Doi: 10.1016/j.str.2022.07.005

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Trafficking of NMDA receptors is essential for hippocampal synaptic plasticity and memory consolidation

Authors: Xin Yang, Ru Gong, Linwei Qin, Yifei Bao, Yi Fu, Shan Gao, Hui Yang, Jinfei Ni, Ti-Fei Yuan, Wei Lu

Journal: Cell Rep

PubMed ID: 35977502

Doi: 10.1016/j.celrep.2022.111217

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Novel antiinflammatory biologics shaped by parasite-host coevolution

Authors: Stephanie M Ryan, Roland Ruscher, Wayne A Johnston, Darren A Pickering, Malcolm W Kennedy, Brian O Smith, Linda Jones, Geraldine Buitrago, Matt A Field, Adrian J Esterman, Connor P McHugh, Daniel J Browne, Martha M Cooper, Rachael Y M Ryan, Denise L Doolan, Christian R Engwerda, Kim Miles, Makedonka Mitreva, John Croese, Tony Rahman, Kirill Alexandrov, Paul R Giacomin, Alex Loukas

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36037362

Doi: 10.1073/pnas.2202795119

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High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails

Authors: Brian R Shy, Vivasvan S Vykunta, Alvin Ha, Alexis Talbot, Theodore L Roth, David N Nguyen, Wolfgang G Pfeifer, Yan Yi Chen, Franziska Blaeschke, Eric Shifrut, Shane Vedova, Murad R Mamedov, Jing-Yi Jing Chung, Hong Li, Ruby Yu, David Wu, Jeffrey Wolf, Thomas G Martin, Carlos E Castro, Lumeng Ye, Jonathan H Esensten, Justin Eyquem, Alexander Marson

Journal: Nat Biotechnol

PubMed ID: 36008610

Doi: 10.1038/s41587-022-01418-8

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Hydrogel Injection Molding to Generate Complex Cell Encapsulation Geometries

Authors: Amy E Emerson, Alec B McCall, Sarah R Brady, Emily M Slaby, Jessica D Weaver

Journal: ACS Biomater Sci Eng

PubMed ID: 36044604

Doi: 10.1021/acsbiomaterials.2c00640

Products & Services: Proteins, Expression, Isolation and Analysis

[Honokiol reduces doxorubicin-induced cardiotoxicity by inhibiting pyroptosis activating AMPK/Nrf2 signaling]

Authors: F Xiong, R Liu, Y Li, N Sun

Journal: Nan Fang Yi Ke Da Xue Xue Bao

PubMed ID: 36073220

Doi: 10.12122/j.issn.1673-4254.2022.08.13

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The neurodevelopmental gene MSANTD2 belongs to a gene family formed by recurrent molecular domestication of Harbinger transposons at the base of vertebrates

Authors: Ema Etchegaray, Dominique Baas, Magali Naville, Zofia Haftek-Terreau, Jean Nicolas Volff

Journal: Mol Biol Evol

PubMed ID: 35980103

Doi: 10.1093/molbev/msac173

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Transient Complexity of Lipidome Is Explained by Fatty Acyl Synthesis and Cyclopropanation

Authors: Nikolay V Berezhnoy, Amaury Cazenave-Gassiot, Liang Gao, Juat Chin Foo, Shanshan Ji, Viduthalai Rasheedkhan Regina, Pui Khee Peggy Yap, Markus R Wenk, Staffan Kjelleberg, Thomas William Seviour, Jamie Hinks

Journal: Metabolites

PubMed ID: 36144187

Doi: 10.3390/metabo12090784

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The Biosynthesis of 1-octene-3-ol by a Multifunctional Fatty Acid Dioxygenase and Hydroperoxide Lyase in

Authors: Tongfu Su, Yuannan Chen, Haohao Liu, Yuqian Gao, Jiawen Guo, Yanan Li, Yuancheng Qi, Liyou Qiu

Journal: J Fungi (Basel)

PubMed ID: 36012815

Doi: 10.3390/jof8080827

Products & Services: Proteins, Expression, Isolation and Analysis

Human Claudin-Derived Peptides Block the Membrane Fusion Process of Zika Virus and Are Broad Flavivirus Inhibitors

Authors: Jim Zoladek, Julien Burlaud-Gaillard, Maxime Chazal, Sophie Desgraupes, Patricia Jeannin, Antoine Gessain, Nathalie Pardigon, Mathieu Hubert, Philippe Roingeard, Nolwenn Jouvenet, Philippe V Afonso

Journal: Microbiol Spectr

PubMed ID: 36040168

Doi: 10.1128/spectrum.02989-22

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TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

Authors: Wendy Wing Sze Yue, Lin Yuan, Joao M Braz, Allan I Basbaum, David Julius

Journal: Elife

PubMed ID: 35968676

Doi: 10.7554/eLife.80139

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Secretion of collagenases by Saccharomyces cerevisiae for collagen degradation

Authors: Han Xiao, Xiufang Liu, Yunzi Feng, Lin Zheng, Mouming Zhao, Mingtao Huang

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 36031598

Doi: 10.1186/s13068-022-02186-y

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Preferential binding of DAP-PGs by major peptidoglycan recognition proteins found in cell-free hemolymph of Manduca sexta

Authors: Udeshika Kariyawasam, Mansi Gulati, Yang Wang, Haibo Bao, Tisheng Shan, Xiuru Li, Xiaolong Cao, Niranji Sumathipala, Yingxia Hu, Xiufeng Zhang, Geert-Jan Boons, Haobo Jiang

Journal: Insect Biochem Mol Biol

PubMed ID: 36007680

Doi: 10.1016/j.ibmb.2022.103827

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Development and application of a rapid all-in-one plasmid CRISPR-Cas9 system for iterative genome editing in Bacillus subtilis

Authors: Yu Zou, Lu Qiu, Aowen Xie, Wenyuan Han, Shangbo Zhang, Jinshan Li, Shumiao Zhao, Yingjun Li, Yunxiang Liang, Yongmei Hu

Journal: Microb Cell Fact

PubMed ID: 35999638

Doi: 10.1186/s12934-022-01896-0

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N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products

Authors: Kyusik Q Kim, Bhagyashri D Burgute, Shin-Cheng Tzeng, Crystal Jing, Courtney Jungers, Junya Zhang, Liewei L Yan, Richard D Vierstra, Sergej Djuranovic, Bradley S Evans, Hani S Zaher

Journal: Cell Rep

PubMed ID: 35988540

Doi: 10.1016/j.celrep.2022.111300

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Myoglobin diet affected the colonic mucus layer and barrier by increasing the abundance of several beneficial gut bacteria

Authors: Shuai Jiang, Dejiang Xue, Miao Zhang, Qian Li, Hui Liu, Di Zhao, Guanghong Zhou, Chunbao Li

Journal: Food Funct

PubMed ID: 35943300

Doi: 10.1039/d2fo01799g

Products & Services: Proteins, Expression, Isolation and Analysis

Microfluidic-Derived Detection of Protein-Facilitated Copper Flux Across Lipid Membranes

Authors: Kamil Górecki, Jesper S Hansen, Ping Li, Niloofar Nayeri, Karin Lindkvist-Petersson, Pontus Gourdon

Journal: Anal Chem

PubMed ID: 35969432

Doi: 10.1021/acs.analchem.2c02081

Products & Services: Bacterial Expression

Expedient Synthesis of Ubiquitin-like Protein ISG15 Tools Through Chemo-Enzymatic Ligation Catalyzed by a Viral Protease Lbpro

Authors: Tian Wang , Chuntong Li , Meijing Wang , Jiachen Zhang , Qingyun Zheng , Lujun Liang , Guochao Chu , Xiaolin Tian , Haiteng Deng , Wei He , Lei Liu , Jinghong Li

Journal: Angew Chem Int Ed Engl

PubMed ID: 35962463

Doi: 10.1002/anie.202206205

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Enhancing the Catalytic Activity of Type II L-Asparaginase from Bacillus licheniformis through Semi-Rational Design

Authors: Yawen Zhou ,Linshu Jiao ,Juan Shen ,Huibing Chi ,Zhaoxin Lu ,Huawei Liu ,Fengxia Lu ,Ping Zhu

Journal: Int J Mol Sci

Doi: 10.3390/ijms23179663

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Dry powder inhalation technology for heart targeting applied to calcium phosphate nanoparticles loaded with active substances

Authors: Eride Quarta,Lorenzo Degli Esposti, Ruggero Bettini ,Fabio Sonvico ,Daniele Catalucci , Michele Iafisco ,Claudio De Luca ,Giovanna Trevisi ,Paolo Colombo ,Alessandra Rossi ,Francesca Buttini , Gaia Colombo

Journal: Drug Delivery Science and Technology

Doi: doi.org/10.1016/j.jddst.2022.103719

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Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides

Authors: Nayeli Escudero Castelán , Dean C Semmens , Luis Alfonso Yañez Guerra , Meet Zandawala , Mario Dos Reis , Susan E Slade , James H Scrivens , Cleidiane G Zampronio , Alexandra M Jones , Olivier Mirabeau , Maurice R Elphick

Journal: BMC Biol

PubMed ID: 36002813

Doi: 10.1186/s12915-022-01387-z

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CRISPR/Cpf1-Mediated Multiplex and Large-Fragment Gene Editing in Staphylococcus aureus

Authors: Zhipeng Wang , Yu Wang , Yujue Wang , Weizhong Chen , Quanjiang Ji

Journal: ACS Synth Biol

PubMed ID: 36001082

Doi: 10.1021/acssynbio.2c00248

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Ultrabright nanoparticle-labeled lateral flow immunoassay for detection of anti-SARS-CoV-2 neutralizing antibodies in human serum

Authors: Lun Bian , Zhaoyue Li , An He , Biru Wu , Hui Yang , Yingsong Wu , Fang Hu , Guanfeng Lin , Deqing Zhang

Journal: Biomaterials

PubMed ID: 35977850

Doi: 10.1016/j.biomaterials.2022.121694

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Subtype-Selective Positive Modulation of KCa2.3 Channels Increases Cilia Length

Authors: Young-Woo Nam , Rajasekharreddy Pala , Naglaa Salem El-Sayed , Denisse Larin-Henriquez , Farideh Amirrad , Grace Yang , Mohammad Asikur Rahman , Razan Orfali , Myles Downey , Keykavous Parang , Surya M Nauli , Miao Zhang

Journal: ACS Chem Biol

PubMed ID: 35947779

Doi: 10.1021/acschembio.2c00469

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Hormone- and antibody-mediated activation of the thyrotropin receptor

Authors: Jia Duan , Peiyu Xu , Xiaodong Luan , Yujie Ji , Xinheng He , Ning Song , Qingning Yuan , Ye Jin , Xi Cheng , Hualiang Jiang , Jie Zheng , Shuyang Zhang , Yi Jiang , H Eric Xu

Journal: Nature

PubMed ID: 35940204

Doi: 10.1038/s41586-022-05173-3

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Growth State-Dependent Expression of Arachidonate Lipoxygenases in the Human Endothelial Cell Line EAhy926

Authors: Mohammad G Sabbir, Jeffrey T Wigle, Carla G Taylor, Peter Zahradka

Journal: Cells

PubMed ID: 36010555

Doi: 10.3390/cells11162478

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The Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19

Authors: Angela J Rogers, Deborah Wentworth, Andrew Phillips, Katy Shaw-Saliba, Robin L Dewar, Neil R Aggarwal, Abdel G Babiker, Weizhong Chang, Nila J Dharan, Victoria J Davey, Elizabeth S Higgs, Norman Gerry, Adit A Ginde, J W Awori Hayanga, Helene Highbarger, Jeroen L Highbarger, Mamta K Jain, Virginia Kan, Kami Kim, Perrine Lallemand, Bradley G Leshnower, Joseph K Lutaakome, Gail Matthews, Ahmad Mourad, Eleftherios Mylonakis, Ven Natarajan, Maria L Padilla, Lavannya M Pandit, Roger Paredes, Sarah Pett, Srikanth Ramachandruni, M Tauseef Rehman, Brad T Sherman, D Clark Files, Samuel M Brown, Michael A Matthay, B Taylor Thompson, James D Neaton, H Clifford Lane, Jens D Lundgren

Journal: Ann Intern Med

PubMed ID: 36037469

Doi: 10.7326/M22-0924

MTP18 inhibition triggers mitochondrial hyperfusion to induce apoptosis through ROS-mediated lysosomal membrane permeabilization-dependent pathway in oral cancer

Authors: Debasna Pritimanjari Panigrahi, Srimanta Patra, Bishnu Prasad Behera, Pradyota Kumar Behera, Shankargouda Patil, Birija Sankar Patro, Laxmidhar Rout, Itisam Sarangi, Sujit Kumar Bhutia

Journal: Free Radic Biol Med

PubMed ID: 35985563

Doi: 10.1016/j.freeradbiomed.2022.08.019

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A cytoskeletal vortex drives phage nucleus rotation during jumbo phage replication in E coli

Authors: Erica A Birkholz, Thomas G Laughlin, Emily Armbruster, Sergey Suslov, Jina Lee, Johannes Wittmann, Kevin D Corbett, Elizabeth Villa, Joe Pogliano

Journal: Cell Rep

PubMed ID: 35977483

Doi: 10.1016/j.celrep.2022.111179

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Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport

Authors: Xiaopan Gao, Huabin Tian, Kaixiang Zhu, Qing Li, Wei Hao, Linyue Wang, Bo Qin, Hongyu Deng, Sheng Cui

Journal: Nat Commun

PubMed ID: 35970938

Doi: 10.1038/s41467-022-32489-5

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The antibody landscapes following AS03 and MF59 adjuvanted H5N1 vaccination

Authors: Johannes B Goll, Aarti Jain, Travis L Jensen, Rafael Assis, Rie Nakajima, Algis Jasinskas, Lynda Coughlan, Sami R Cherikh, Casey E Gelber, S Khan, D Huw Davies, Philip Meade, Daniel Stadlbauer, Shirin Strohmeier, Florian Krammer, Wilbur H Chen, Philip L Felgner

Journal: npj Vaccines

PubMed ID: 36042229

Doi: 10.1038/s41541-022-00524-7

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Circular RNA hsa_circ_0007367 promotes the progression of pancreatic ductal adenocarcinoma by sponging miR-6820-3p and upregulating YAP1 expression

Authors: Haocheng Zhang, Xiaolei Ma, Luning Wang, Xinyu Li, Di Feng, Meiming Liu, Jiayang Li, Mengxing Cheng, Na Song, Xinxia Yang, Lina Ba, Yating Lei, Ruipu Zhang, Yunxiao Zhu, Wenxiao Xu, Guofen Qiao

Journal: Cell Death Dis

PubMed ID: 36008392

Doi: 10.1038/s41419-022-05188-8

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The Catalytic Subunit of CK2 (Cka1) Negatively Regulates RNA Polymerase II Transcription through Phosphorylation of Positive Cofactor 4 (PC4)

Authors: Diego A Rojas, Fabiola Urbina, Aldo Solari, Edio Maldonado

Journal: Int J Mol Sci

PubMed ID: 36012759

Doi: 10.3390/ijms23169499

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Transcriptional changes in LMH cells induced by rhoptry kinase family protein 17

Authors: Yi-Jing Meng, Bing-Jin Mu, Xiao-Xin Liu, Lin-Mei Yu, Wen-Bin Zheng, Shi-Chen Xie, Wen-Wei Gao, Xing-Quan Zhu, Qing Liu

Journal: Front Vet Sci

PubMed ID: 36016802

Doi: 10.3389/fvets.2022.956040

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Structural basis for receptor selectivity and inverse agonism in S1P receptors

Authors: Elizaveta Lyapina, Egor Marin, Anastasiia Gusach, Philipp Orekhov, Andrey Gerasimov, Aleksandra Luginina, Daniil Vakhrameev, Margarita Ergasheva, Margarita Kovaleva, Georgii Khusainov, Polina Khorn, Mikhail Shevtsov, Kirill Kovalev, Sergey Bukhdruker, Ivan Okhrimenko, Petr Popov, Hao Hu, Uwe Weierstall, Wei Liu, Yunje Cho, Ivan Gushchin, Andrey Rogachev, Gleb Bourenkov, Sehan Park, Gisu Park, Hyo Jung Hyun, Jaehyun Park, Valentin Gordeliy, Valentin Borshchevskiy, Alexey Mishin, Vadim Cherezov

Journal: Nat Commun

PubMed ID: 35961984

Doi: 10.1038/s41467-022-32447-1

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Strong T-cell activation in response to COVID-19 vaccination in multiple sclerosis patients receiving B-cell depleting therapies

Authors: Roberto Alfonso-Dunn, Jerry Lin, Vanessa Kirschner, Joyce Lei, Grant Feuer, Michaela Malin, Jiayuan Liu, Morgan Roche, Saud A Sadiq

Journal: Front Immunol

PubMed ID: 35990701

Doi: 10.3389/fimmu.2022.926318

CpG content in the Zika virus genome affects infection phenotypes in the adult brain and fetal lymph nodes

Authors: Daniel Udenze, Ivan Trus, Nathalie Berube, Uladzimir Karniychuk

Journal: Front Immunol

PubMed ID: 35983032

Doi: 10.3389/fimmu.2022.943481

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Engineering an adenine base editor in human embryonic stem cells with minimal DNA and RNA off-target activities

Authors: Zhenwu Zhang, Wanyu Tao, Shisheng Huang, Wenjun Sun, Yue Wang, Wen Jiang, Xingxu Huang, Chao-Po Lin

Journal: Mol Ther Nucleic Acids

PubMed ID: 35991312

Doi: 10.1016/j.omtn.2022.07.026

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Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure

Authors: Eva K Oernbo, Annette B Steffensen, Pooya Razzaghi Khamesi, Trine L Toft-Bertelsen, Dagne Barbuskaite, Frederik Vilhardt, Niklas J Gerkau, Katerina Tritsaris, Anja H Simonsen, Sara D Lolansen, Søren N Andreassen, Steen G Hasselbalch, Thomas Zeuthen, Christine R Rose, Vartan Kurtcuoglu, Nanna MacAulay

Journal: Fluids Barriers CNS

PubMed ID: 36038945

Doi: 10.1186/s12987-022-00358-4

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Signal Peptide-rheostat Dynamics Delay Secretory Preprotein Folding

Authors: Dries Smets, Jochem Smit, Ying Xu, Spyridoula Karamanou, Anastassios Economou

Journal: J Mol Biol

PubMed ID: 35970402

Doi: 10.1016/j.jmb.2022.167790

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assessment of simultaneous G1 cyclins silencing by a tumor-specific bidirectional promoter on the mammary tumor in nude mice

Authors: Gholamreza Mesbah, Fatemeh Namazi, Fatemeh T Shamsabadi, Zahra Maleki, Mehrab Nasirikenari, Majid Shahbazi

Journal: Front Vet Sci

PubMed ID: 36072388

Doi: 10.3389/fvets.2022.914311

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Effects of boosted mRNA and adenoviral-vectored vaccines on immune responses to omicron BA1 and BA2 following the heterologous CoronaVac/AZD1222 vaccination

Authors: Nungruthai Suntronwong, Sitthichai Kanokudom, Chompoonut Auphimai, Suvichada Assawakosri, Thanunrat Thongmee, Preeyaporn Vichaiwattana, Thaneeya Duangchinda, Warangkana Chantima, Pattarakul Pakchotanon, Jira Chansaenroj, Jiratchaya Puenpa, Pornjarim Nilyanimit, Donchida Srimuan, Thaksaporn Thatsanatorn, Natthinee Sudhinaraset, Nasamon Wanlapakorn, Juthathip Mongkolsapaya, Yong Poovorawan

Journal: J Med Virol

PubMed ID: 35924475

Doi: 10.1002/jmv.28044

Products & Services: Proteins, Expression, Isolation and Analysis

A Rapid Translational Immune Response Program in CD8 Memory T Lymphocytes

Authors: Darin Salloum, Kamini Singh, Natalie R Davidson, Linlin Cao, David Kuo, Viraj R Sanghvi, Man Jiang, Maria Tello Lafoz, Agnes Viale, Gunnar Ratsch, Hans-Guido Wendel

Journal: J Immunol

PubMed ID: 36002234

Doi: 10.4049/jimmunol.2100537

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Dual peptide-functionalized hydrogels differentially control periodontal cell function and promote tissue regeneration

Authors: David Fraser, Danielle Benoit

Journal: Biomater Adv

PubMed ID: 36067642

Doi: 10.1016/j.bioadv.2022.213093

Products & Services: Proteins, Expression, Isolation and Analysis

Manipulation of peptide-fatty acid bioconjugates on graphene: effects of fatty acid chain length and attachment point

Authors: Yuliana Perdomo, Ruitao Jin, Atul D Parab, Marc R Knecht, Tiffany R Walsh

Journal: J Mater Chem B

PubMed ID: 35894139

Doi: 10.1039/d2tb01104b

Products & Services: Proteins, Expression, Isolation and Analysis

Immunogenicity and Protective Efficacy of a Recombinant Pichinde Viral-Vectored Vaccine Expressing Influenza Virus Hemagglutinin Antigen in Pigs

Authors: Sushmita Kumari, Jayeshbhai Chaudhari, Qinfeng Huang, Phillip Gauger, Marcelo Nunes De Almeida, Yuying Liang, Hinh Ly, Hiep L X Vu

Journal: Vaccines (Basel)

PubMed ID: 36146478

Doi: 10.3390/vaccines10091400

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Translational potential of base-editing tools for gene therapy of monogenic diseases

Authors: Vasiliy V Reshetnikov, Angelina V Chirinskaite, Julia V Sopova, Roman A Ivanov, Elena I Leonova

Journal: Front Bioeng Biotechnol

PubMed ID: 36032737

Doi: 10.3389/fbioe.2022.942440

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Quorum Sensing Regulation of a Major Facilitator Superfamily Transporter Affects Multiple Streptococcal Virulence Factors

Authors: Jennifer C Chang, Reid V Wilkening, Kate M Rahbari, Michael J Federle

Journal: J Bacteriol

PubMed ID: 35938850

Doi: 10.1128/jb.00176-22

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A computational approach to rapidly design peptides that detect SARS-CoV-2 surface protein S

Authors: Maryam Hajikarimlou, Mohsen Hooshyar, Mohamed Taha Moutaoufik, Khaled A Aly, Taha Azad, Sarah Takallou, Sasi Jagadeesan, Sadhna Phanse, Kamaledin B Said, Bahram Samanfar, John C Bell, Frank Dehne, Mohan Babu, Ashkan Golshani

Journal: NAR Genom Bioinform

PubMed ID: 36004308

Doi: 10.1093/nargab/lqac058

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Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells

Authors: Sjoukje J C van der Stegen, Pieter L Lindenbergh, Roseanna M Petrovic, Hongyao Xie, Mame P Diop, Vera Alexeeva, Yuzhe Shi, Jorge Mansilla-Soto, Mohamad Hamieh, Justin Eyquem, Annalisa Cabriolu, Xiuyan Wang, Ramzey Abujarour, Tom Lee, Raedun Clarke, Bahram Valamehr, Maria Themeli, Isabelle Riviere, Michel Sadelain

Journal: Nat Biomed Eng

PubMed ID: 35941192

Doi: 10.1038/s41551-022-00915-0

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Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

Authors: Laura J Stevens, Andrea J Pruijssers, Hery W Lee, Calvin J Gordon, Egor P Tchesnokov, Jennifer Gribble, Amelia S George, Tia M Hughes, Xiaotao Lu, Jiani Li, Jason K Perry, Danielle P Porter, Tomas Cihlar, Timothy P Sheahan, Ralph S Baric, Matthias Götte, Mark R Denison

Journal: Sci Transl Med

PubMed ID: 35482820

Doi: 10.1126/scitranslmed.abo0718

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EmCyclinD-EmCDK4/6 complex is involved in the host EGF-mediated proliferation of germinative cells the EGFR-ERK pathway

Authors: Chonglv Feng, Zhe Cheng, Zhijian Xu, Ye Tian, Huimin Tian, Fan Liu, Damin Luo, Yanhai Wang

Journal: Front Microbiol

PubMed ID: 36033888

Doi: 10.3389/fmicb.2022.968872

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CGG repeats trigger translational frameshifts that generate aggregation-prone chimeric proteins

Authors: Shannon E Wright, Caitlin M Rodriguez, Jeremy Monroe, Jiazheng Xing, Amy Krans, Brittany N Flores, Venkatesha Barsur, Magdalena I Ivanova, Kristin S Koutmou, Sami J Barmada, Peter K Todd

Journal: Nucleic Acids Res

PubMed ID: 35904811

Doi: 10.1093/nar/gkac626

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Simulating androgen receptor selection in designer yeast

Authors: Haoran Zhang, Lu Zhang, Yipeng Xu, Shaoyong Chen, Zhenyi Ma, Mingdong Yao, Fangyin Li, Bo Li, Yingjin Yuan

Journal: Synth Syst Biotechnol

PubMed ID: 36017332

Doi: 10.1016/j.synbio.2022.07.005

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Endoplasmic stress-inducing variants in carboxyl ester lipase and pancreatic cancer risk

Authors: Makoto Kawamoto, Takeichi Yoshida, Koji Tamura, Mohamad Dbouk, Marcia Irene Canto, Richard Burkhart, Jin He, Nicholas J Roberts, Alison P Klein, Michael Goggins

Journal: Pancreatology

PubMed ID: 35995657

Doi: 10.1016/j.pan.2022.08.004

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Structures of topoisomerase V in complex with DNA reveal unusual DNA-binding mode and novel relaxation mechanism

Authors: Amy Osterman, Alfonso Mondragón

Journal: Elife

PubMed ID: 35969036

Doi: 10.7554/eLife.72702

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The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation

Authors: Kohei Kusakari, Takeshi Machida, Yumi Ishida, Tomoko Omori, Toshiyuki Suzuki, Masayuki Sekimata, Ikuo Wada, Teizo Fujita, Hideharu Sekine

Journal: Front Immunol

PubMed ID: 36052069

Doi: 10.3389/fimmu.2022.907023

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Severe congenital myasthenic syndromes caused by agrin mutations affecting secretion by motoneurons

Authors: Arnaud Jacquier, Valérie Risson, Thomas Simonet, Florine Roussange, Nicolas Lacoste, Shams Ribault, Julien Carras, Julian Theuriet, Emmanuelle Girard, Isabelle Grosjean, Laure Le Goff, Stephan Kröger, Julia Meltoranta, Stéphanie Bauché, Damien Sternberg, Emmanuel Fournier, Anna Kostera-Pruszczyk, Emily O'Connor, Bruno Eymard, Hanns Lochmüller, Cécile Martinat, Laurent Schaeffer

Journal: Acta Neuropathol

PubMed ID: 35948834

Doi: 10.1007/s00401-022-02475-8

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Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer's disease

Authors: Yue Dong, Hanqiao Yu, Xueqi Li, Kelong Bian, Yayuan Zheng, Mingrui Dai, Xuejian Feng, Yao Sun, Yu He, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kong

Journal: J Neuroinflammation

PubMed ID: 35971179

Doi: 10.1186/s12974-022-02567-y

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A High-Throughput Search for SFXN1 Physical Partners Led to the Identification of ATAD3, HSD10 and TIM50

Authors: Nesrine Tifoun, Mourad Bekhouche, José M De Las Heras, Arnaud Guillaume, Sylvina Bouleau, Isabelle Guénal, Bernard Mignotte, Nathalie Le Floch

Journal: Biology (Basel)

PubMed ID: 36138777

Doi: 10.3390/biology11091298

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High-titre production of aromatic amines in metabolically engineered Escherichia coli

Authors: Taiwei Yang, Peiling Wu, Yang Zhang, Mingfeng Cao, Jifeng Yuan

Journal: J Appl Microbiol

PubMed ID: 35938518

Doi: 10.1111/jam.15745

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Salvianolic acid B activates chondrocytes autophagy and reduces chondrocyte apoptosis in obese mice via the KCNQ1OT1/miR-128-3p/SIRT1 signaling pathways

Authors: Tianwen Sun, Fei Wang, Gaojian Hu, Zhizhou Li

Journal: Nutr Metab (Lond)

PubMed ID: 35922815

Doi: 10.1186/s12986-022-00686-0

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