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A context-dependent and disordered ubiquitin-binding motif

Authors: Jesper E Dreier, Andreas Prestel, João M Martins, Sebastian S Brøndum, Olaf Nielsen, Anna E Garbers, Hiroaki Suga, Wouter Boomsma, Joseph M Rogers, Rasmus Hartmann-Petersen, Birthe B Kragelund

Journal: Cell Mol Life Sci

PubMed ID: 35974206

Doi: 10.1007/s00018-022-04486-w

Products & Services: Plasmid DNA Preparation

Comparative genomics of mortal and immortal cnidarians unveils novel keys behind rejuvenation

Authors: Maria Pascual-Torner, Dido Carrero, José G Pérez-Silva, Diana Álvarez-Puente, David Roiz-Valle, Gabriel Bretones, David Rodríguez, Daniel Maeso, Elena Mateo-González, Yaiza Español, Guillermo Mariño, José Luis Acuña, Víctor Quesada, Carlos López-Otín

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36037356

Doi: 10.1073/pnas.2118763119

Products & Services: Gene Synthesis

Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment

Authors: Athanasios Papadas, Gauri Deb, Alexander Cicala, Adam Officer, Chelsea Hope, Adam Pagenkopf, Evan Flietner, Zachary T Morrow, Philip Emmerich, Joshua Wiesner, Garrett Arauz, Varun Bansal, Karla Esbona, Christian M Capitini, Kristina A Matkowskyj, Dustin A Deming, Katerina Politi, Scott I Abrams, Olivier Harismendy, Fotis Asimakopoulos

Journal: Cell Rep

PubMed ID: 35977482

Doi: 10.1016/j.celrep.2022.111201

Products & Services: Proteins, Expression, Isolation and Analysis

Comparison of replicating and nonreplicating vaccines against SARS-CoV-2

Authors: Haley E Mudrick, Shane Massey, Erin B McGlinch, Brian J Parrett, Jack R Hemsath, Mary E Barry, Jeffrey D Rubin, Chisom Uzendu, Michael J Hansen, Courtney L Erskine, Virginia P Van Keulen, Aleksandra Drelich, Joseph A Panos, Madiha Fida, Gina A Suh, Tobias Peikert, Matthew S Block, Chien-Te Kent Tseng, Gloria R Olivier, Michael A Barry

Journal: Sci Adv

PubMed ID: 36001674

Doi: 10.1126/sciadv.abm8563

Detection of Anticancer Drug-Induced Cardiotoxicity Using VCAM1-Targeted Nanoprobes

Authors: Humayra Afrin, Md Nurul Huda, Tamanna Islam, Beu P Oropeza, Efren Alvidrez, Muhammad I Abir, Thomas Boland, David Turbay, Md Nurunnabi

Journal: ACS Appl Mater Interfaces

PubMed ID: 35939041

Doi: 10.1021/acsami.2c13019

Products & Services: Proteins, Expression, Isolation and Analysis

latent liver infection is characterized by persistent hypnozoites, hypnozoite-derived schizonts, and time-dependent efficacy of primaquine

Authors: Erika L Flannery, Niwat Kangwanrangsan, Vorada Chuenchob, Wanlapa Roobsoong, Matthew Fishbaugher, Kevin Zhou, Zachary P Billman, Thomas Martinson, Tayla M Olsen, Carola Schäfer, Brice Campo, Sean C Murphy, Sebastian A Mikolajczak, Stefan H I Kappe, Jetsumon Sattabongkot

Journal: Mol Ther Methods Clin Dev

PubMed ID: 36092359

Doi: 10.1016/j.omtm.2022.07.016

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Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals

Authors: Chenxi Wang, Runkang Qu, Yanan Zong, Chao Qin, Litao Liu, Xiaoyi Gao, Honglei Sun, Yipeng Sun, Kin-Chow Chang, Rui Zhang 1 , Jinhua Liu 1 , Juan Pu 1

Journal: PLoS Pathog

PubMed ID: 35793327

Doi: 10.1371/journal.ppat.1010645

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Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1

Authors: Yu Jin , Zhen Liu , Zhenxia Li , Hairui Li , Cheng Zhu , Ruomei Li , Ting Zhou , Bing Fang

Journal: Int J Oral Sci

PubMed ID: 35831280

Doi: 10.1038/s41368-022-00190-4

Products & Services: Peptide Synthesis

Simultaneous quantification of SMN1 and SMN2 copy numbers by MALDI-TOF mass spectrometry for spinal muscular atrophy genetic testing

Authors: Weijiang Jin , Zhengquan Yang , Xiaojun Tang , Xiuchao Wang , Yaxin Huang , Chenmin Hui , Jiaming Yao , Ju Luan , Shaohua Tang , Shengnan Wu , Shengnan Jin , Chunming Ding

Journal: Clin Chim Acta

PubMed ID: 35643151

Doi: 10.1016/j.cca.2022.05.017

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Golgin Subfamily A Member 5 Is Essential for Production of Extracellular Matrix Proteins during TGF-1-Induced Periodontal Ligament-Fibroblastic Differentiation

Authors: Hyun-Jin Kim, Seong-Min Kim, Min-Jeong Choi, Young-Joo Jang

Journal: Stem Cells Int

PubMed ID: 35879965

Doi: 10.1155/2022/3273779

Products & Services: Mammalian Expression

Urinary CD8+HLA-DR+ T Cell Abundance Non-invasively Predicts Kidney Transplant Rejection

Authors: Emil Grothgar, Nina Goerlich, Bjoern Samans, Christopher M Skopnik, Diana Metzke, Jan Klocke, Luka Prskalo, Paul Freund, Leonie Wagner, Michael Duerr, Mareen Matz, Sven Olek, Klemens Budde, Alexander Paliege, Philipp Enghard

Journal: Front Med (Lausanne)

PubMed ID: 35911418

Doi: 10.3389/fmed.2022.928516

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Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP

Authors: Takeshi Yokoyama, Shiho Fujii, Andreas Ostermann, Tobias E Schrader, Yuko Nabeshima, Mineyuki Mizuguchi

Journal: IUCrJ

PubMed ID: 36071806

Doi: 10.1107/S2052252522006297

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Surface cysteine to serine substitutions in IL-18 reduce aggregation and enhance activity

Authors: Jirakrit Saetang, Niran Roongsawang, Surasak Sangkhathat, Supayang Piyawan Voravuthikunchai, Natnaree Sangkaew, Napat Prompat, Teerapol Srichana, Varomyalin Tipmanee

Journal: PeerJ

PubMed ID: 35811828

Doi: 10.7717/peerj.13626

Products & Services: Plasmid DNA Preparation

Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA

Authors: Qiuxia Chen, You Li, Chunrong Lin, Liu Chen, Hao Luo, Shuai Xia, Chuan Liu, Xuemin Cheng, Chengzhong Liu, Jin Li, Dengfeng Dou

Journal: Nucleic Acids Res

PubMed ID: 35288754

Doi: 10.1093/nar/gkac173

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The role of CFA/I in adherence and toxin delivery by ETEC expressing multiple colonization factors in the human enteroid model

Authors: Emily M Smith, Christen L Grassel, Antonia Papadimas, Jennifer Foulke-Abel, Eileen M Barry

Journal: PLoS Negl Trop Dis

PubMed ID: 35881640

Doi: 10.1371/journal.pntd.0010638

Products & Services: Proteins, Expression, Isolation and Analysis

Insight into bacterial community profiles of oil shale and sandstone in ordos basin by culture-dependent and culture-independent methods

Authors: Fengdan Wei, Rui Xu, Yuanyuan Xu, Tao Cheng, Yanling Ma

Journal: J Environ Sci Health A Tox Hazard Subst Environ Eng

PubMed ID: 35903918

Doi: 10.1080/10934529.2022.2105631

Products & Services: DNA Sequencing

Enhancing epitope of PEDV spike protein

Authors: Techit Thavorasak, Monrat Chulanetra, Kittirat Glab-Ampai, Kodchakorn Mahasongkram, Nawannaporn Sae-Lim, Karsidete Teeranitayatarn, Thaweesak Songserm, Rungrueang Yodsheewan, Dachrit Nilubol, Wanpen Chaicumpa, Nitat Sookrung

Journal: Front Microbiol

PubMed ID: 35935230

Doi: 10.3389/fmicb.2022.933249

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Self-Assembling Protein Surfaces for Capture of Cell-Free-Synthesized Proteins

Authors: Ella Lucille Thornton, Sarah Maria Paterson, Zoe Gidden, Mathew H Horrocks, Nadanai Laohakunakorn, Lynne Regan

Journal: Front Bioeng Biotechnol

PubMed ID: 35875503

Doi: 10.3389/fbioe.2022.915035

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Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2

Authors: Brandon Wey-Hung Liauw, Arash Foroutan, Michael R Schamber, Weifeng Lu, Hamid Samareh Afsari, Reza Vafabakhsh

Journal: Elife

PubMed ID: 35775730

Doi: 10.7554/eLife.78982

Products & Services: DNA Sequencing

Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains

Authors: James Brett Case, Samantha Mackin, John M Errico, Zhenlu Chong, Emily A Madden, Bradley Whitener, Barbara Guarino, Michael A Schmid, Kim Rosenthal, Kuishu Ren, Ha V Dang, Gyorgy Snell, Ana Jung, Lindsay Droit, Scott A Handley, Peter J Halfmann, Yoshihiro Kawaoka, James E Crowe, Daved H Fremont, Herbert W Virgin, Yueh-Ming Loo, Mark T Esser, Lisa A Purcell, Davide Corti, Michael S Diamond

Journal: Nat Commun

PubMed ID: 35780162

Doi: 10.1038/s41467-022-31615-7

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PTPRO knockdown protects against inflammation in hemorrhage shock-induced lung injury involving the NF-κB signaling pathway

Authors: Zhirong Huan, Ying Tang, Ce Xu, Jimin Cai, Hao Yao, Yan Wang, Fanyu Bu, Xin Ge

Journal: Respir Res

PubMed ID: 35906634

Doi: 10.1186/s12931-022-02118-2

Products & Services: Mammalian Expression

Membrane fluidity, composition, and charge affect the activity and selectivity of the AMP ascaphin-8

Authors: Adriana Morales-Martínez, Brandt Bertrand, Juan M Hernández-Meza, Ramón Garduño-Juárez, Jesús Silva-Sanchez, Carlos Munoz-Garay

Journal: Biophys J

PubMed ID: 35842753

Doi: 10.1016/j.bpj.2022.07.018

Products & Services: GenCrispr Cas9 Genome Editing

Construction of a T7 phage display nanobody library for bio-panning and identification of chicken dendritic cell-specific binding nanobodies

Authors: Hai Xu, Ling Li, Bihua Deng, Weiming Hong, Ruiting Li, Zijie Guo, Jibo Hou, Roshini Govinden, Hafizah Y Chenia

Journal: Sci Rep

PubMed ID: 35840654

Doi: 10.1038/s41598-022-16378-x

Products & Services: DNA Sequencing

Ca attenuates nucleation activity of leiomodin

Authors: Garry E Smith, Dmitri Tolkatchev, Cristina Risi, Madison Little, Carol C Gregorio, Vitold E Galkin, Alla S Kostyukova

Journal: Protein Sci

PubMed ID: 35762710

Doi: 10.1002/pro.4358

Products & Services: Proteins, Expression, Isolation and Analysis

A Single Vaccination of Chimeric Bivalent Virus-Like Particle Vaccine Confers Protection Against H9N2 and H3N2 Avian Influenza in Commercial Broilers and Allows a Strategy of Differentiating Infected from Vaccinated Animals

Authors: Yi-Xue Sun, Zheng-Rong Li, Peng-Ju Zhang, Jin-Hong Han, Hai-Yang Di, Jia-Yi Qin, Yan-Long Cong

Journal: Front Immunol

PubMed ID: 35874682

Doi: 10.3389/fimmu.2022.902515

Products & Services: Gene Synthesis

Engineering a tunable bicistronic TetR autoregulation expression system in

Authors: Monica Bertucci, Ky Ariano, Meg Zumsteg, Paul Schweiger

Journal: PeerJ

PubMed ID: 35873911

Doi: 10.7717/peerj.13639

Products & Services: PCR Cloning and Subcloning

Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus

Authors: Francesco Aulicino, Martin Pelosse, Christine Toelzer, Julien Capin, Erwin Ilegems, Parisa Meysami, Ruth Rollarson, Per-Olof Berggren, Mark Simon Dillingham, Christiane Schaffitzel, Moin A Saleem, Gavin I Welsh, Imre Berger

Journal: Nucleic Acids Res

PubMed ID: 35801912

Doi: 10.1093/nar/gkac587

Products & Services: Synthetic sgRNA and crRNA Service

Durability of the Neutralizing Antibody Response to mRNA Booster Vaccination Against SARS-CoV-2 BA2121 and BA4/5 Variants

Authors: Panke Qu, Julia N Faraone, John P Evans, Yi-Min Zheng, Claire Carlin, Gerard Lozanski, Linda J Saif, Eugene M Oltz, Richard J Gumina, Shan-Lu Liu

Journal: biorxiv

PubMed ID: 35898337

Doi: 10.1101/2022.07.21.501010

Products & Services: Plasmid DNA Preparation

Impact of the temperature on the interactions between common variants of the SARS-CoV-2 receptor binding domain and the human ACE2

Authors: Catherine Forest-Nault, Izel Koyuturk, Jimmy Gaudreault, Alex Pelletier, Denis L'Abbé, Brian Cass, Louis Bisson, Alina Burlacu, Laurence Delafosse, Matthew Stuible, Olivier Henry, Gregory De Crescenzo, Yves Durocher

Journal: Sci Rep

PubMed ID: 35798770

Doi: 10.1038/s41598-022-15215-5

Products & Services: Mammalian Expression

Limited Correlation between SARS-CoV-2 Serologic Assays for Identification of High-Titer COVID-19 Convalescent Plasma Using FDA Thresholds

Authors: Nicholas E Larkey, Radwa Ewaisha, Michael A Lasho, Matthew M Roforth, Dane Granger, Calvin R Jerde, Liang Wu, Amy Gorsh, Stephen A Klassen, Jonathon W Senefeld, Michael J Joyner, Nikola A Baumann, Elitza S Theel, John R Mills

Journal: Microbiol Spectr

PubMed ID: 35862939

Doi: 10.1128/spectrum.01154-22

Pro-Survival Factor EDEM3 Confers Therapy Resistance in Prostate Cancer

Authors: Emma Scott, Rebecca Garnham, Kathleen Cheung, Adam Duxfield, David J Elliott, Jennifer Munkley

Journal: Int J Mol Sci

PubMed ID: 35897761

Doi: 10.3390/ijms23158184

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An adaptable platform for in-house hepatitis C serology

Authors: Jannie Pedersen, Irène Pegha Moukandja, Stella Ndidi, Anna-Louise Sørensen, Ismaël Hervé Koumakpayi, Jean-Bernard Lekana-Douki, Marie-Louise Vachon, Nina Weis, Gary Kobinger, Hugues Fausther-Bovendo

Journal: J Virol Methods

PubMed ID: 35850366

Doi: 10.1016/j.jviromet.2022.114586

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Physical activity and antibody persistence 6 months after the second dose of CoronaVac in immunocompromised patients

Authors: Bruno Gualano, Ítalo Ribeiro Lemes, Rafael Pires da Silva, Ana Jéssica Pinto, Bruna Caruso Mazzolani, Fabiana Infante Smaira, Sofia Mendes Sieczkowska, Nádia Emi Aikawa, Sandra Pasoto, Ana Cristina Medeiros-Ribeiro, Carla Saad, Emily Yuk, Clovis Silva, Paul Swinton, Pedro Curi Hallal, Hamilton Roschel, Eloisa Bonfa

Journal: Scand J Med Sci Sports

PubMed ID: 35844042

Doi: 10.1111/sms.14213

High Mobility Group Protein B1 Decreases Surface Localization of PD-1 to Augment T-cell Activation

Authors: Qun Gao, Shumin Wang, Feng Li, Jingyao Lian, Shaoyan Cheng, Dongli Yue, Zhen Zhang, Shasha Liu, Feifei Ren, Daiqun Zhang, Shengdian Wang, Liping Wang, Yi Zhang

Journal: Cancer Immunol Res

PubMed ID: 35580259

Doi: 10.1158/2326-6066.CIR-21-0652

Products & Services: Recombinant Proteins

Structures of the T cell potassium channel Kv13 with immunoglobulin modulators

Authors: Purushotham Selvakumar, Ana I Fernández-Mariño, Nandish Khanra, Changhao He, Alice J Paquette, Bing Wang, Ruiqi Huang, Vaughn V Smider, William J Rice, Kenton J Swartz, Joel R Meyerson

Journal: Nat Commun

PubMed ID: 35788586

Doi: 10.1038/s41467-022-31285-5

Products & Services: Plasmid DNA Preparation

Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition

Authors: Elena G Govorunova , Yueyang Gou , Oleg A Sineshchekov , Hai Li , Xiaoyu Lu , Yumei Wang , Leonid S Brown , François St-Pierre , Mingshan Xue , John L Spudich

Journal: Nature neuroscience

PubMed ID: 35726059

Doi: 10.1038/s41593-022-01094-6

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Core cysteine residues in the Plasminogen-Apple-Nematode (PAN) domain are critical for HGF/c-MET signaling

Authors: Debjani Pal , Kuntal De , Carly M Shanks , Kai Feng , Timothy B Yates , Jennifer Morrell-Falvey , Russell B Davidson , Jerry M Parks , Wellington Muchero

Journal: Commun Biol

PubMed ID: 35778602

Doi: 10.1038/s42003-022-03582-8

Products & Services: Proteins, Expression, Isolation and Analysis

Hsp70 inhibits the replication of Fowl Adenovirous serotype 4 by suppressing viral Hexon with the assistance of DnaJC7

Authors: Jie Cao , Shuhui Liu , Meng Liu , Shuaiwen Wang , Zhenwei Bi , Wentao Fan , Zhiyu Shi , Suquan Song , Liping Yan

Journal: J Virol

PubMed ID: 35852354

Doi: 10.1128/jvi.00807-22

Products & Services: Proteins, Expression, Isolation and Analysis

Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker

Authors: Aslan Mansurov , Peyman Hosseinchi, Kevin Chang, Abigail L Lauterbach, Laura T Gray , Aaron T Alpar , Erica Budina , Anna J Slezak , Seounghun Kang, Shijie Cao, Ani Solanki , Suzana Gomes , John-Michael Williford, Melody A Swartz , Juan L Mendoza , Jun Ishihara , Jeffrey A Hubbell

Journal: Nat Biomed Eng

PubMed ID: 35534574

Doi: 10.1038/s41551-022-00888-0

Products & Services: Mammalian Expression

Identification of nucleoside monophosphates and their epigenetic modifications using an engineered nanopore.

Authors: Yuqin Wang , Shanyu Zhang , Wendong Jia ,Pingping Fan , Liying Wang , Xinyue Li , Jialu Chen , Zhenyuan Cao , Xiaoyu Du , Yao Liu , Kefan Wang , Chengzhen Hu , Jinyue Zhang , Jun Hu , Panke Zhang , Hong-Yuan Chen , Shuo Huang

Journal: Nat Nanotechnol

PubMed ID: 35851382

Doi: 10.1038/s41565-022-01169-2

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Oncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancer

Authors: Qiuman Wang , Xinyue Ma , Huan Wu , Chen Zhao 1, Jingying Chen , Rongrong Li , Shi Yan , Yingwei Li , Qing Zhang , Kun Song , Cunzhong Yuan , Beihua Kong

Journal: Oncoimmunology

PubMed ID: 35800156

Doi: 10.1080/2162402X.2022.2096362 Free PMC article

Products & Services: Proteins, Expression, Isolation and Analysis

Developing and validating SARS-CoV-2 assays for nonhuman primate surveillance

Authors: JoAnn Yee, Amanda Carpenter, Peter Nham, Bryson Halley, Koen K A Van Rompay, Jeffrey Roberts

Journal: J Med Primatol

PubMed ID: 35794847

Doi: 10.1111/jmp.12604

Products & Services: Mammalian Expression

Correction: High level SARS-CoV-2 nucleocapsid refolding using mild condition for inclusion bodies solubilization: Application of high pressure at pH 90

Authors:

Journal: PLoS ONE

PubMed ID: 35788214

Doi: 10.1371/journal.pone.0271140

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CaMKII Inhibition Attenuates Distinct Gain-of-Function Effects Produced by Mutant Nav16 Channels and Reduces Neuronal Excitability

Authors: Agnes S Zybura, Firoj K Sahoo, Andy Hudmon, Theodore R Cummins

Journal: Cells

PubMed ID: 35805192

Doi: 10.3390/cells11132108

Products & Services: Mammalian Expression

Ancestrally Reconstructed von Willebrand Factor Reveals Evidence for Trench Warfare Coevolution between Opossums and Pit Vipers

Authors: Danielle H Drabeck, Alexandra Rucavado, Erika Hingst-Zaher, Antony Dean, Sharon A Jansa

Journal: Mol Biol Evol

PubMed ID: 35723968

Doi: 10.1093/molbev/msac140

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Efficient multiplex CRISPR/Cpf1 (Cas12a) genome editing system in Aspergillus aculeatus TBRC 277

Authors: Dede Abdulrachman, Verawat Champreda, Lily Eurwilaichitr, Duriya Chantasingh, Kusol Pootanakit

Journal: J Biotechnol

PubMed ID: 35788357

Doi: 10.1016/j.jbiotec.2022.06.011

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Calcium responses to external mechanical stimuli in the multicellular stage of Dictyostelium discoideum

Authors: Hidenori Hashimura, Yusuke V Morimoto, Yusei Hirayama, Masahiro Ueda

Journal: Sci Rep

PubMed ID: 35859163

Doi: 10.1038/s41598-022-16774-3

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miR-301b-5p and its target gene nfatc2ip regulate inflammatory responses in the liver of rainbow trout (Oncorhynchus mykiss) under high temperature stress

Authors: Tianqing Huang, Wei Gu, Enhui Liu, Bingqian Wang, Gaochao Wang, Fulin Dong, Fuyuan Guo, Wenlong Jiao, Yanchun Sun, Xiance Wang, Shanwei Li, Gefeng Xu

Journal: Ecotoxicol Environ Saf

PubMed ID: 35901591

Doi: 10.1016/j.ecoenv.2022.113915

Products & Services: Plasmid DNA Preparation

A Single Dose of Anti-HBsAg Antibody-Encoding mRNA-LNPs Suppressed HBsAg Expression: a Potential Cure of Chronic Hepatitis B Virus Infection

Authors: Binfan Chen, Yuchen Chen, Jian Li, Chunyu Wang, Wenping Song, Yumei Wen, Jinzhong Lin, Yanling Wu, Tianlei Ying

Journal: MBio

PubMed ID: 35862767

Doi: 10.1128/mbio.01612-22

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An immunodetection assay developed using cobra cytotoxin-specific antibodies: Potential diagnostics for cobra envenoming

Authors: Hui Ling Ong, Choo Hock Tan, Louisa Pernee Lee, Sook Mei Khor, Kae Yi Tan

Journal: Toxicon

PubMed ID: 35868411

Doi: 10.1016/j.toxicon.2022.07.010

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Phage defence by deaminase-mediated depletion of deoxynucleotides in bacteria

Authors: Brian Y Hsueh, Geoffrey B Severin, Clinton A Elg, Evan J Waldron, Abhiruchi Kant, Alex J Wessel, John A Dover, Christopher R Rhoades, Benjamin J Ridenhour, Kristin N Parent, Matthew B Neiditch, Janani Ravi, Eva M Top, Christopher M Waters

Journal: Nat Microbiol

PubMed ID: 35817890

Doi: 10.1038/s41564-022-01162-4

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Development of Melioidosis Subunit Vaccines Using an Enzymatically Inactive Burkholderia pseudomallei AhpC

Authors: Lindsey K Schmidt, Caitlyn E Orne, Teresa L Shaffer, Shane M Wilson, Nittaya Khakhum, Alfredo G Torres, Paul J Brett, Mary N Burtnick

Journal: Infect Immun

PubMed ID: 35862715

Doi: 10.1128/iai.00222-22

Products & Services: Proteins, Expression, Isolation and Analysis

Development and characterization of an inducible assay system to measure Zika virus capsid interactions

Authors: Jieshi Yu, Chen Huang, Zhao Wang, Radhey S Kaushik, Zizhang Sheng, Feng Li, Dan Wang

Journal: J Med Virol

PubMed ID: 35822280

Doi: 10.1002/jmv.27991

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SARS-CoV-2 Omicron escapes mRNA vaccine booster-induced antibody neutralisation in patients with autoimmune rheumatic diseases: an observational cohort study

Authors: Woo-Joong Kim, Seong-Ho Choi, Ji Young Park, Jung Soo Song, Jin-Won Chung, Sang Tae Choi

Journal: Ann Rheum Dis

PubMed ID: 35878999

Doi: 10.1136/ard-2022-222689

SARS-CoV-2 Epitopes following Infection and Vaccination Overlap Known Neutralizing Antibody Sites

Authors: Li Yang, Te Liang, Lane M Pierson, Hongye Wang, Jesse K Fletcher, Shu Wang, Duran Bao, Lili Zhang, Zhen Huang, Wenshu Zheng, Xiaomei Zhang, Heewon Park, Yuwen Li, James E Robinson, Amy K Feehan, Christopher J Lyon, Jing Cao, Lisa A Morici, Chenzhong Li, Chad J Roy, Xiaobo Yu, Tony Hu

Journal: Research (Wash D C)

PubMed ID: 35928300

Doi: 10.34133/2022/9769803

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Phage Particles of Controlled Length and Genome for Targeted Glioblastoma Imaging and Therapeutic Delivery

Authors: Uyanga Tsedev, Ching-Wei Lin, Gaelen T Hess, Jann N Sarkaria, Fred C Lam, Angela M Belcher

Journal: ACS Nano

PubMed ID: 35830573

Doi: 10.1021/acsnano.1c08720

Products & Services: Plasmid DNA Preparation

RG203KR Mutations in SARS-CoV-2 Nucleocapsid: Assessing the Impact Using a Virus-Like Particle Model System

Authors: Harsha Raheja, Soma Das, Anindita Banerjee, Dikshaya P, Deepika C, Debanjan Mukhopadhyay, Subbaraya G Ramachandra, Saumitra Das

Journal: Microbiol Spectr

PubMed ID: 35862952

Doi: 10.1128/spectrum.00781-22

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Development of an in-house quantitative ELISA for the evaluation of different Covid-19 vaccines in humans

Authors: Mariem Gdoura, Fatma Ben Ghaloum, Meriem Ben Hamida, Wafa Chamsa, Henda Triki, Chokri Bahloul

Journal: Sci Rep

PubMed ID: 35788676

Doi: 10.1038/s41598-022-15378-1

In situ architecture of the lipid transport protein VPS13C at ER-lysosome membrane contacts

Authors: Shujun Cai, Yumei Wu, Andrés Guillén-Samander, William Hancock-Cerutti, Jun Liu, Pietro De Camilli

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35858323

Doi: 10.1073/pnas.2203769119

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The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency Pathway

Authors: Lindsay C Sidak-Loftis, Kristin L Rosche, Natasha Pence, Jessica K Ujczo, Joanna Hurtado, Elis A Fisk, Alan G Goodman, Susan M Noh, John W Peters, Dana K Shaw

Journal: MBio

PubMed ID: 35862781

Doi: 10.1128/mbio.00703-22

Products & Services: Mammalian Expression

In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus

Authors: Linda B Oyama, Hamza Olleik, Ana Carolina Nery Teixeira, Matheus M Guidini, James A Pickup, Brandon Yeo Pei Hui, Nicolas Vidal, Alan R Cookson, Hannah Vallin, Toby Wilkinson, Denise M S Bazzolli, Jennifer Richards, Mandy Wootton, Ralf Mikut, Kai Hilpert, Marc Maresca, Josette Perrier, Matthias Hess, Hilario C Mantovani, Narcis Fernandez-Fuentes, Christopher J Creevey, Sharon A Huws

Journal: NPJ Biofilms Microbiomes

PubMed ID: 35835775

Doi: 10.1038/s41522-022-00320-0

Products & Services: Proteins, Expression, Isolation and Analysis

Sequence grammar underlying the unfolding and phase separation of globular proteins

Authors: Kiersten M Ruff, Yoon Hee Choi, Dezerae Cox, Angelique R Ormsby, Yoochan Myung, David B Ascher, Sheena E Radford, Rohit V Pappu, Danny M Hatters

Journal: Mol Cell

PubMed ID: 35853451

Doi: 10.1016/j.molcel.2022.06.024

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The Patterning and Proportion of Charged Residues in the Arginine-Rich Mixed-Charge Domain Determine the Membrane-Less Organelle Targeted by the Protein

Authors: Tamami Miyagi, Rio Yamazaki, Koji Ueda, Satoshi Narumi, Yuhei Hayamizu, Hiroshi Uji-I, Masahiko Kuroda, Kohsuke Kanekura

Journal: Int J Mol Sci

PubMed ID: 35887012

Doi: 10.3390/ijms23147658

Products & Services: Bacterial Expression

Conformational landscape of the yeast SAGA complex as revealed by cryo-EM

Authors: Diana Vasyliuk, Joeseph Felt, Ellen D Zhong, Bonnie Berger, Joseph H Davis, Calvin K Yip

Journal: Sci Rep

PubMed ID: 35853968

Doi: 10.1038/s41598-022-16391-0

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos

Authors: Fanye Meng, Chenxi Xu, Kwang-Su Park, H Ümit Kaniskan, Gang Greg Wang, Jian Jin

Journal: J Med Chem

PubMed ID: 35895319

Doi: 10.1021/acs.jmedchem.2c00807

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Cholesterol Deprivation Drives DHEA Biosynthesis in Human Adrenals

Authors: Emanuele Pignatti, Emre Murat Altinkilic, Konstantin Bräutigam, Michael Grössl, Aurel Perren, Mihaela Zavolan, Christa E Flück

Journal: Endocrinology

PubMed ID: 35583599

Doi: 10.1210/endocr/bqac076

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Screening circular RNAs with functional potential using the RfxCas13d/BSJ-gRNA system

Authors: Siqi Li, Hao Wu, Ling-Ling Chen

Journal: Nat Protoc

PubMed ID: 35831613

Doi: 10.1038/s41596-022-00715-5

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An Engineered λ Phage Enables Enhanced and Strain-Specific Killing of Enterohemorrhagic Escherichia coli

Authors: Menglu Jin, Jingchao Chen, Xueyang Zhao, Guoru Hu, Hailei Wang, Zhi Liu, Wei-Hua Chen

Journal: Microbiol Spectr

PubMed ID: 35876591

Doi: 10.1128/spectrum.01271-22

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Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut

Authors: Víctor Taleb, Qinghua Liao, Yoshiki Narimatsu, Ana García-García, Ismael Compañón, Rafael Junqueira Borges, Andrés Manuel González-Ramírez, Francisco Corzana, Henrik Clausen, Carme Rovira, Ramon Hurtado-Guerrero

Journal: Nat Commun

PubMed ID: 35882872

Doi: 10.1038/s41467-022-32021-9

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Rhesus rotavirus receptor-binding site affects high mobility group box 1 release, altering the pathogenesis of experimental biliary atresia

Authors: Sujit K Mohanty, Bryan Donnelly, Haley Temple, Sarah Mowery, Holly M Poling, Jaroslaw Meller, Astha Malik, Monica McNeal, Greg Tiao

Journal: Hepatol Commun

PubMed ID: 35866580

Doi: 10.1002/hep4.2024

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The transient expression of recombinant proteins in plant cell packs facilitates stable isotope labelling for NMR spectroscopy

Authors: Patrick Opdensteinen, Laura E Sperl, Mariam Mohamadi, Nicole Kündgen-Redding, Franz Hagn, Johannes Felix Buyel

Journal: Plant Biotechnol J

PubMed ID: 35702941

Doi: 10.1111/pbi.13873

Products & Services: Proteins, Expression, Isolation and Analysis

Antitumor efficacy of MUC1-derived variable epitope library treatments in a mouse model of breast cancer

Authors: Josué Odales, Rodolfo Servín-Blanco, Fernando Martínez-Cortés, Jesus Guzman Valle, Allan Noé Domínguez-Romero, Goar Gevorkian, Karen Manoutcharian

Journal: Vaccine

PubMed ID: 35788294

Doi: 10.1016/j.vaccine.2022.06.062

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O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1

Authors: Qiang Zhu, Hong Zhou, Liming Wu, Zhenyuan Lai, Didi Geng, Weiwei Yang, Jie Zhang, Zhiya Fan, Weijie Qin, Yong Wang, Ruhong Zhou, Wen Yi

Journal: Nat Chem Biol

PubMed ID: 35879546

Doi: 10.1038/s41589-022-01085-5

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Reprogramming of Human B Cells from Secreting IgG to IgM by Genome Editing

Authors: Guigao Lin, Kuo Zhang, Yanxi Han, Rongxue Peng, Jiawei Zhang, Dandan Li, Jinming Li

Journal: CRISPR J

PubMed ID: 35900273

Doi: 10.1089/crispr.2021.0093

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Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice

Authors: Yuning Liu, Hong Xing, Alexis F Ernst, Canna Liu, Christian Maugee, Fumiaki Yokoi, Madepalli Lakshmana, Yuqing Li

Journal: Mol Cell Neurosci

PubMed ID: 35843530

Doi: 10.1016/j.mcn.2022.103756

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Bacteria deplete deoxynucleotides to defend against bacteriophage infection

Authors: Nitzan Tal, Adi Millman, Avigail Stokar-Avihail, Taya Fedorenko, Azita Leavitt, Sarah Melamed, Erez Yirmiya, Carmel Avraham, Alexander Brandis, Tevie Mehlman, Gil Amitai, Rotem Sorek

Journal: Nat Microbiol

PubMed ID: 35817891

Doi: 10.1038/s41564-022-01158-0

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Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge

Authors: Shanna S Leventhal, Kimberly Meade-White, Deepashri Rao, Elaine Haddock, Jacqueline Leung, Dana Scott, Jacob Archer, Samantha Randall, Jesse H Erasmus, Heinz Feldmann, David W Hawman

Journal: EBioMedicine

PubMed ID: 35907368

Doi: 10.1016/j.ebiom.2022.104188

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Tumor-Localized Administration of α-GalCer to Recruit Invariant Natural Killer T Cells and Enhance Their Antitumor Activity against Solid Tumors

Authors: Yan-Ruide Li, Yang Zhou, Matthew Wilson, Adam Kramer, Ryan Hon, Yichen Zhu, Ying Fang, Lili Yang

Journal: Int J Mol Sci

PubMed ID: 35886891

Doi: 10.3390/ijms23147547

Products & Services: Recombinant Proteins

Paraneoplastic Pemphigus Autoantibodies Against C-terminus of Desmoplakin Induced Acantholysis and

Authors: Xue Wang, Rui Wang, Dingfang Bu, Leyi Wang, Yuexin Zhang, Yuan Chang, Chenyang Zhang, Xixue Chen, Xuejun Zhu, Zhi Liu, Mingyue Wang

Journal: Front Immunol

PubMed ID: 35911677

Doi: 10.3389/fimmu.2022.886226

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Protective effects of small heat shock proteins in Daphnia magna against heavy metal exposure

Authors: Muyi Li, Ting Tang, Fengyu Yuan, Yuming Zhang, Fengchao Li, Fengsong Liu

Journal: Sci Total Environ

PubMed ID: 35907523

Doi: 10.1016/j.scitotenv.2022.157565

Products & Services: Proteins, Expression, Isolation and Analysis

Development and applications of a TaqMan based quantitative real-time PCR for the rapid detection of Pigeon circovirus (PiCV)

Authors: Babu K Nath, Shubhagata Das, Tridip Das, Jade K Forwood, Shane R Raidal

Journal: J Virol Methods

PubMed ID: 35870671

Doi: 10.1016/j.jviromet.2022.114588

Products & Services: Proteins, Expression, Isolation and Analysis

The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE mice

Authors: Yishi Shen, Hong-Mei Gu, Lei Zhai, Binxiang Wang, Shucun Qin, Da-Wei Zhang

Journal: Biochim Biophys Acta Mol Cell Biol Lipids

PubMed ID: 35803528

Doi: 10.1016/j.bbalip.2022.159196

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Development and Assessment of Herpes Simplex Virus Type 1 (HSV-1) Amplicon Vectors with Sensory Neuron-Selective Promoters

Authors: Charles Joussain, Olivier Le Coz, Andrey Pichugin, Peggy Marconi, Filip Lim, Mariaconcetta Sicurella, Keith Foster, François Giuliano, Alberto L Epstein, Alejandro Aranda Muñoz

Journal: Int J Mol Sci

PubMed ID: 35955608

Doi: 10.3390/ijms23158474

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Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis

Authors: Nikola Kenjić, Kathleen M Meneely, Daniel J Wherritt, Melissa C Denler, Timothy A Jackson, Graham R Moran, Audrey L Lamb

Journal: J Am Chem Soc

PubMed ID: 35802469

Doi: 10.1021/jacs.2c03376

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Impacts of a Zwitterionic Peptide on its Fusion Protein

Authors: Patrick McMullen, Liang Fang, Qi Qiao, Qing Shao, Shaoyi Jiang

Journal: Bioconjug Chem

PubMed ID: 35852436

Doi: 10.1021/acs.bioconjchem.2c00176

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Immunogenicity of the third and fourth BNT162b2 mRNA COVID-19 boosters and factors associated with immune response in patients with SLE and rheumatoid arthritis

Authors: Theerada Assawasaksakul, Seelwan Sathitratanacheewin, Preeyaporn Vichaiwattana, Nasamon Wanlapakorn, Yong Poovorawan, Yingyos Avihingsanon, Nawaporn Assawasaksakul, Wonngarm Kittanamongkolchai

Journal: Lupus Sci Med

PubMed ID: 35902168

Doi: 10.1136/lupus-2022-000726

HOXB5-activated ANGPT2 promotes the proliferation, migration, invasion and angiogenic effect of esophageal cancer cells via activating ERK/AKT signaling pathway

Authors: Jing Li, Shanshan Gao

Journal: Exp Ther Med

PubMed ID: 35949323

Doi: 10.3892/etm.2022.11522

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The Relative Positioning of B and T Cell Epitopes Drives Immunodominance

Authors: Riccardo Biavasco, Marco De Giovanni

Journal: Vaccines (Basel)

PubMed ID: 36016115

Doi: 10.3390/vaccines10081227

Products & Services: Mammalian Expression

Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation

Authors: Charline Mary, Mona Hoseini Soflaee, Rushendhiran Kesavan, Muriel Gelin, Harrison Brown, G Zacharias, Thomas P Mathews, Andrew Lemoff, Corinne Lionne, Gilles Labesse, Gerta Hoxhaj

Journal: Mol Cell

PubMed ID: 35868311

Doi: 10.1016/j.molcel.2022.06.026

Products & Services: Mammalian Expression

A Novel Cre/lox71-Based System for Inducible Expression of Recombinant Proteins and Genome Editing

Authors: Maxim Karagyaur, Daniyar Dyikanov, Pyotr Tyurin-Kuzmin, Stalik Dzhauari, Mariya Skryabina, Maksim Vigovskiy, Alexandra Primak, Natalia Kalinina, Vsevolod Tkachuk

Journal: Cells

PubMed ID: 35883584

Doi: 10.3390/cells11142141

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ArsR Family Regulator MSMEG_6762 Mediates the Programmed Cell Death by Regulating the Expression of HNH Nuclease in Mycobacteria

Authors: Xiangke Duan, Xue Huang, Junqi Xu, Xue Li, Jingjing Niu, Xiaoli Du, Xiaoyu Wang, Jiang Li, Michael Kelly, Jiaohan Guo, Ke Zhang, Yu Huang, Biao Kan, Jianping Xie

Journal: Microorganisms

PubMed ID: 36013953

Doi: 10.3390/microorganisms10081535

Products & Services: Proteins, Expression, Isolation and Analysis

Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis

Authors: Yize Liu, Guanzhen Qiu, Yinzhou Luo, Shanshan Li, Yeqiu Xu, Yuanzhuang Zhang, Jiayuan Hu, Peifeng Li, Hai Pan, Yong Wang

Journal: Exp Mol Med

PubMed ID: 35879346

Doi: 10.1038/s12276-022-00806-z

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Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents

Authors: Jiyun Zhu, Linfeng Li, Aleksandra Drelich, Bala C Chenna, Drake M Mellott, Zane W Taylor, Vivian Tat, Christopher Z Garcia, Ardala Katzfuss, Chien-Te K Tseng, Thomas D Meek

Journal: Front Chem

PubMed ID: 35860632

Doi: 10.3389/fchem.2022.867928

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Comprehensive Evaluation and Comparison of Machine Learning Methods in QSAR Modeling of Antioxidant Tripeptides

Authors: Zhenjiao Du, Donghai Wang, Yonghui Li

Journal: ACS Omega

PubMed ID: 35910147

Doi: 10.1021/acsomega.2c03062

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Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes

Authors: Jean Mukherjee, Celinia A Ondeck, Jacqueline M Tremblay, Jacob Archer, Michelle Debatis, Alexa Foss, Junya Awata, Jesse H Erasmus, Patrick M McNutt, Charles B Shoemaker

Journal: Sci Rep

PubMed ID: 35803998

Doi: 10.1038/s41598-022-15876-2

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Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures

Authors: Marlen Kruse, Basma Altattan, Eva-Maria Laux, Nico Grasse, Lars Heinig, Christin Möser, David M Smith, Ralph Hölzel

Journal: Sci Rep

PubMed ID: 35896714

Doi: 10.1038/s41598-022-16914-9

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HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations

Authors: Yong Du, Yongfeng Chen, Yuxia Wang, Jinju Chen, Xiaorong Lu, Li Zhang, Yan Li, Zhaofu Wang, Guozhong Ye, George Zhang

Journal: Mol Cancer Ther

PubMed ID: 35499406

Doi: 10.1158/1535-7163.MCT-21-0835

Products & Services: Proteins, Expression, Isolation and Analysis

Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis

Authors: Zachary Armstrong, Richard W Meek, Liang Wu, James N Blaza, Gideon J Davies

Journal: Structure

PubMed ID: 35907402

Doi: 10.1016/j.str.2022.07.001

Products & Services: Mutant Libraries

Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis

Authors: Wenli Liu, Nataliya Östberg, Mustafa Yalcinkaya, Huijuan Dou, Kaori Endo-Umeda, Yang Tang, Xintong Hou, Tong Xiao, Trevor P Fidler, Sandra Abramowicz, Yong-Guang Yang, Oliver Soehnlein, Alan R Tall, Nan Wang

Journal: J Clin Invest

PubMed ID: 35587375

Doi: 10.1172/JCI155724

Products & Services: Recombinant Proteins

Construction of a Novel Clinical Stage-Related Gene Signature for Predicting Outcome and Immune Response in Hepatocellular Carcinoma

Authors: Liu Yang, Long-Fei Zeng, Guo-Qing Hong, Qing Luo, Xing Lai

Journal: J Immunol Res

PubMed ID: 35865652

Doi: 10.1155/2022/6535009

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