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Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor

Authors: Xiyuan Zhang, Hannah E Lou, Vishaka Gopalan, Zhihui Liu, Hilda M Jafarah, Haiyan Lei, Paige Jones, Carly M Sayers, Marielle E Yohe, Prashant Chittiboina, Brigitte C Widemann, Carol J Thiele, Michael C Kelly, Sridhar Hannenhalli, Jack F Shern

Journal: Cell Rep

PubMed ID: 36130486

Doi: 10.1016/j.celrep.2022.111363

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Alamandine alleviated heart failure and fibrosis in myocardial infarction mice

Authors: Kun Zhao, Tianhua Xu, Yukang Mao, Xiaoguang Wu, Dongxu Hua, Yanhui Sheng, Peng Li

Journal: Biol Direct

PubMed ID: 36167556

Doi: 10.1186/s13062-022-00338-6

Products & Services: Custom DNA/RNA Oligos

Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors

Authors: Jordan R Willis, Zachary T Berndsen, Krystal M Ma, Jon M Steichen, Torben Schiffner, Elise Landais, Alessia Liguori, Oleksandr Kalyuzhniy, Joel D Allen, Sabyasachi Baboo, Oluwarotimi Omorodion, Jolene K Diedrich, Xiaozhen Hu, Erik Georgeson, Nicole Phelps, Saman Eskandarzadeh, Bettina Groschel, Michael Kubitz, Yumiko Adachi, Tina-Marie Mullin, Nushin B Alavi, Samantha Falcone, Sunny Himansu, Andrea Carfi, Ian A Wilson, John R Yates, James C Paulson, Max Crispin, Andrew B Ward, William R Schief

Journal: Immunity

PubMed ID: 36179689

Doi: 10.1016/j.immuni.2022.09.001

Products & Services: Recombinant Antibody Expression

Intranasal Immunization with Liposome-Displayed Receptor-Binding Domain Induces Mucosal Immunity and Protection against SARS-CoV-2

Authors: Wei-Chiao Huang, Kevin Chiem, Luis Martinez-Sobrido, Jonathan F Lovell

Journal: Pathogens

PubMed ID: 36145467

Doi: 10.3390/pathogens11091035

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Inactivated COVID-19 vaccines: durability of Covaxin/BBV152 induced immunity against variants of concern

Authors: Nathella Pavan Kumar, V V Banurekha, C P Girish Kumar, Arul Nancy, Chandrasekaran Padmapriyadarsini, Sakila Shankar, Luke Elizabeth Hanna, Manoj Murhekar, K R Uma Devi, Subash Babu

Journal: J Travel Med

PubMed ID: 35900009

Doi: 10.1093/jtm/taac088

Products & Services: Recombinant Proteins

High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity

Authors: Rodrigo Vazquez-Lombardi, Johanna S Jung, Fabrice S Schlatter, Anna Mei, Natalia Rodrigues Mantuano, Florian Bieberich, Kai-Lin Hong, Jakub Kucharczyk, Edo Kapetanovic, Erik Aznauryan, Cédric R Weber, Alfred Zippelius, Heinz Läubli, Sai T Reddy

Journal: Immunity

PubMed ID: 36174557

Doi: 10.1016/j.immuni.2022.09.004

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mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts

Authors: Denzil Furtado, Christina Cortez-Jugo, Ya Hui Hung, Ashley I Bush, Frank Caruso

Journal: Mol Pharm

PubMed ID: 36125338

Doi: 10.1021/acs.molpharmaceut.2c00463

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A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity

Authors: Lian-Sheng Cheng, Yong-Feng Cheng, Wen-Ting Liu, Aolin Shen, Dayan Zhang, Tingjuan Xu, Wu Yin, Min Cheng, Xiaopeng Ma, Fengrong Wang, Qun Zhao, Xiaoli Zeng, Yan Zhang, Guodong Shen

Journal: J Transl Med

PubMed ID: 36076251

Doi: 10.1186/s12967-022-03619-w

Products & Services: Mammalian Expression

H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity

Authors: Huasong Ai , Maoshen Sun , Aijun Liu , Zixian Sun , Tingting Liu , Lin Cao , Lujun Liang , Qian Qu , Zichen Li , Zhiheng Deng , Zebin Tong , Guochao Chu , Xiaolin Tian , Haiteng Deng , Suwen Zhao , Jia-Bin Li , Zhiyong Lou , Lei Liu

Journal: Nat Chem Biol

PubMed ID: 35739357

Doi: 10.1038/s41589-022-01067-7

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The SOS response-associated peptidase (SRAP) domain of YedK catalyzes ring opening of abasic sites and reversal of its DNA–protein cross-link

Authors: Katherine A Paulin , David Cortez , Brandt F Eichman

Journal: J Biol Chem

PubMed ID: 35934051

Doi: 10.1016/j.jbc.2022.102307

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Guide RNA engineering enables efficient CRISPR editing with a miniature Syntrophomonas palmitatica Cas12f1 nuclease

Authors: Yujue Wang , Yannan Wang ， Deng Pan , Haopeng Yu , Yifei Zhang , Weizhong Chen , Fan Li , Zhaowei Wu , Quanjiang Ji

Journal: Cell Rep

PubMed ID: 36170834

Doi: doi.org/10.1016/j.celrep.2022.111418

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Nilaparvata lugens salivary protein NlG14 triggers defense response in plants

Authors: Haoli Gao , Jianzheng Zou , Xumin Lin , Huihui Zhang , Na Yu , Zewen Liu

Journal: J Exp Bot

PubMed ID: 36056768

Doi: 10.1093/jxb/erac354

Products & Services: Proteins, Expression, Isolation and Analysis

Proposal to Consider Chemical/Physical Microenvironment as a New Therapeutic Off-Target Approach

Authors: Alessandro Giuliani, Stefano Fais

Journal: Pharmaceutics

PubMed ID: 36297518

Doi: 10.3390/pharmaceutics14102084

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Autophagic flux restoration of senescent T cells improves antitumor activity of TCR-engineered T cells

Authors: Chaoting Zhang, Yizhe Sun, Shance Li, Luyan Shen, Xia Teng, Yefei Xiao, Ping Zhou, Zheming Lu

Journal: Clin Transl Immunology

PubMed ID: 36188121

Doi: 10.1002/cti2.1419

Products & Services: Plasmid DNA Preparation

Development of a GalNAc-Tyrosine-Specific Monoclonal Antibody and Detection of Tyrosine -GalNAcylation in Numerous Human Tissues and Cell Lines

Authors: Li Xia, Tiffany R Bellomo, Ruslan Gibadullin, Molly D Congdon, Elijah F Edmondson, Mi Li, Alexander Wlodawer, Crystal Li, J Sebastian Temme, Pavan Patel, Donna Butcher, Jeffrey C Gildersleeve

Journal: J Am Chem Soc

PubMed ID: 36054098

Doi: 10.1021/jacs.2c04477

Products & Services: Mammalian Expression

Febuxostat Alleviates Allergic Rhinitis by Inhibiting Inflammation and Monocyte Adhesion in Human Nasal Epithelial Cells via Regulating KLF6

Authors: Yuting Yao, Ran Wei, Hui Jiang

Journal: Evid Based Complement Alternat Med

PubMed ID: 36118091

Doi: 10.1155/2022/9092311

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Mitochondrial derived peptide MOTS-c prevents the development of heart failure under pressure overload conditions in mice

Authors: Peng Zhong, Jianye Peng, Yewen Hu, Jun Zhang, Caijie Shen

Journal: J Cell Mol Med

PubMed ID: 36156853

Doi: 10.1111/jcmm.17551

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Simple and practical sialoglycan encoding system reveals vast diversity in nature and identifies a universal sialoglycan-recognizing probe derived from AB5 toxin B subunits

Authors: Aniruddha Sasmal, Naazneen Khan, Zahra Khedri, Benjamin P Kellman, Saurabh Srivastava, Andrea Verhagen, Hai Yu, Anders Bech Bruntse, Sandra Diaz, Nissi Varki, Travis Beddoe, Adrienne W Paton, James C Paton, Xi Chen, Nathan E Lewis, Ajit Varki

Journal: Glycobiology

PubMed ID: 36048714

Doi: 10.1093/glycob/cwac057

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Recombinant COVID-19 vaccine based on recombinant RBD/Nucleoprotein and saponin adjuvant induces long-lasting neutralizing antibodies and cellular immunity

Authors: Amir Ghaemi, Parisa Roshani Asl, Hedieh Zargaran, Delaram Ahmadi, Asim Ali Hashimi, Elahe Abdolalipour, Sahar Bathaeian, Seyed Mohammad Miri

Journal: Front Immunol

PubMed ID: 36159845

Doi: 10.3389/fimmu.2022.974364

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Effects of TAMP family on the tight junction strand network and barrier function in epithelial cells

Authors: Akira C Saito, Chisato Endo, Yugo Fukazawa, Tomohito Higashi, Hideki Chiba

Journal: Ann N Y Acad Sci

PubMed ID: 36069127

Doi: 10.1111/nyas.14889

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Riboflavin salvage by Borrelia burgdorferi supports carbon metabolism and is essential for survival in the tick vector

Authors: Darlene Ramos, Amanda G Lasseter, Crystal L Richards, Benjamin Schwarz, Susmita Ghosh, Berta Victoria, Catharine M Bosio, Frank C Gherardini, Mollie W Jewett

Journal: Mol Microbiol

PubMed ID: 36054485

Doi: 10.1111/mmi.14977

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De novo sphingolipid biosynthesis necessitates detoxification in cancer cells

Authors: Meghan E Spears, Namgyu Lee, Sunyoung Hwang, Sung Jin Park, Anne E Carlisle, Rui Li, Mihir B Doshi, Aaron M Armando, Jenny Gao, Karl Simin, Lihua Julie Zhu, Paul L Greer, Oswald Quehenberger, Eduardo M Torres, Dohoon Kim

Journal: Cell Rep

PubMed ID: 36170811

Doi: 10.1016/j.celrep.2022.111415

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Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein

Authors: Xiaoxiao Ren, Huijuan Zhu, Keyong Deng, Xiaotong Ning, Lin Li, Dan Liu, Bin Yang, Chenyang Shen, Xianqiang Wang, Naqiong Wu, Shufeng Chen, Dongfeng Gu, Laiyuan Wang

Journal: Arterioscler Thromb Vasc Biol

PubMed ID: 36172865

Doi: 10.1161/ATVBAHA.122.318158

Products & Services: Proteins, Expression, Isolation and Analysis

RUP2 facilitates UVR8 redimerization via two interfaces

Authors: Lixia Wang, Yidong Wang, Hongfei Chang, Hui Ren, Xinquan Wu, Jia Wen, Zeyuan Guan, Ling Ma, Liang Qiu, Junjie Yan, Delin Zhang, Xi Huang, Ping Yin

Journal: Plant Commun

PubMed ID: 36065466

Doi: 10.1016/j.xplc.2022.100428

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Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies

Authors: Cathrine Scheepers, Prudence Kgagudi, Nonkululeko Mzindle, Elin S Gray, Thandeka Moyo-Gwete, Bronwen E Lambson, Brent Oosthuysen, Batsirai Mabvakure, Nigel J Garrett, Salim S Abdool Karim, Lynn Morris, Penny L Moore

Journal: PLoS Pathog

PubMed ID: 36054228

Doi: 10.1371/journal.ppat.1010450

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Identification of Aedes aegypti salivary gland proteins interacting with human immune receptor proteins

Authors: Edem Gavor, Yeu Khai Choong, Yonghao Liu, Julien Pompon, Eng Eong Ooi, Yu Keung Mok, Haiyan Liu, R Manjunatha Kini, J Sivaraman

Journal: PLoS Negl Trop Dis

PubMed ID: 36070318

Doi: 10.1371/journal.pntd.0010743

Products & Services: Insect Expression

Anti-Phytophthora Activity of Halofuginone and the Corresponding Mode of Action

Authors: Saisai Zhang, Jialing Cai, Yimeng Xie, Xinyu Zhang, Xilang Yang, Shenyuan Lin, Wensheng Xiang, Ji Zhang

Journal: J Agric Food Chem

PubMed ID: 36126316

Doi: 10.1021/acs.jafc.2c04266

Products & Services: Proteins, Expression, Isolation and Analysis

SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins

Authors: Tyler D R Vance, Patrick Yip, Elisabet Jiménez, Sheng Li, Diana Gawol, James Byrnes, Isabel Usón, Ahmed Ziyyat, Jeffrey E Lee

Journal: Commun Biol

PubMed ID: 36115925

Doi: 10.1038/s42003-022-03883-y

Products & Services: Proteins, Expression, Isolation and Analysis

EuRBG10 involved in indole alkaloids biosynthesis in Eucommia ulmoides induced by drought and salt stresses

Authors: Yanjun Zuo, Bairu Li, Suixia Guan, Jingyu Jia, Xinjie Xu, Zilong Zhang, Zheng Lu, Xin Li, Xinyue Pang

Journal: J Plant Physiol

PubMed ID: 36179396

Doi: 10.1016/j.jplph.2022.153813

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Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia

Authors: Houfang Long, Shengnan Zhang, Shuyi Zeng, Yilun Tong, Jun Liu, Cong Liu, Dan Li

Journal: Cell Rep

PubMed ID: 36130498

Doi: 10.1016/j.celrep.2022.111401

Products & Services: Proteins, Expression, Isolation and Analysis

Protein Stabilization by Alginate Binding and Suppression of Thermal Aggregation

Authors: Roger Chang, Martin Gruebele, Deborah E Leckband

Journal: Biomacromolecules

PubMed ID: 36054903

Doi: 10.1021/acs.biomac.2c00297

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Small Molecule Antibiotics Inhibit Distinct Stages of Bacterial Outer Membrane Protein Assembly

Authors: Janine H Peterson, Matthew Thomas Doyle, Harris D Bernstein

Journal: MBio

PubMed ID: 36165532

Doi: 10.1128/mbio.02286-22

Products & Services: Monoclonal Antibody Services

Unveiling the Essential Role of Arkadia's Non-RING Elements in the Ubiquitination Process

Authors: Maria Birkou, Georgia N Delegkou, Konstantinos D Marousis, Nefeli Fragkaki, Tamara Toro, Vasso Episkopou, Georgios A Spyroulias

Journal: Int J Mol Sci

PubMed ID: 36142504

Doi: 10.3390/ijms231810585

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De Novo design of a humanized antiCD33 antibody-oridonin conjugate for acute myeloid leukemia therapy

Authors: Hui Feng, Yi Liu, Mengyao Zhang, Ruimin Liu, Jincheng Wang, Wenjuan Wang, Pengcheng He, Penghui Zhang, Fan Niu

Journal: Biochem Biophys Res Commun

PubMed ID: 36122452

Doi: 10.1016/j.bbrc.2022.09.032

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Cutaneous kinase activity correlates with treatment outcomes following PI3K delta inhibition in mice with experimental pemphigoid diseases

Authors: Saeedeh Ghorbanalipoor, Shirin Emtenani, Melissa Parker, Mayumi Kamaguchi, Colin Osterloh, Manuela Pigors, Natalie Gross, Stanislav Khil'chenko, Anika Kasprick, Sabrina Patzelt, Diana Wortmann, Ibrahim O Ibrahim, Kentaro Izumi, Stephanie Goletz, Katharina Boch, Kathrin Kalies, Katja Bieber, Paul Smith, Enno Schmidt, Ralf J Ludwig

Journal: Front Immunol

PubMed ID: 36248903

Doi: 10.3389/fimmu.2022.865241

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A bead-based method for high-throughput mapping of the sequence- and force-dependence of T cell activation

Authors: Yinnian Feng, Xiang Zhao, Adam K White, K Christopher Garcia, Polly M Fordyce

Journal: Nat Methods

PubMed ID: 36064771

Doi: 10.1038/s41592-022-01592-2

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Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirus

Authors: Scott A Rush, Gurpreet Brar, Ching-Lin Hsieh, Emilie Chautard, Jennifer N Rainho-Tomko, Chris D Slade, Christine A Bricault, Ana Kume, James Kearns, Rachel Groppo, Sophia T Mundle, Linong Zhang, Danilo Casimiro, Tong-Ming Fu, Joshua M DiNapoli, Jason S McLellan

Journal: Cell Rep

PubMed ID: 36130517

Doi: 10.1016/j.celrep.2022.111399

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Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy

Authors: Andrea Raspadori, Valentina Vignali, Anna Murello, Gabriele Giachin, Bruno Samorì, Motomasa Tanaka, Carlos Bustamante, Giampaolo Zuccheri, Giuseppe Legname

Journal: Biology (Basel)

PubMed ID: 36138837

Doi: 10.3390/biology11091358

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Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma

Authors: Akira Nakamizo, Yuichiro Miyamatsu, Haruka Hirose, Toshiyuki Amano, Satoshi Matsuo, Minako Fujiwara, Teppei Shimamura, Koji Yoshimoto

Journal: Sci Rep

PubMed ID: 36175487

Doi: 10.1038/s41598-022-20613-w

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The Musashi proteins direct post-transcriptional control of protein expression and alternate exon splicing in vertebrate photoreceptors

Authors: Fatimah Matalkah, Bohye Jeong, Macie Sheridan, Eric Horstick, Visvanathan Ramamurthy, Peter Stoilov

Journal: Commun Biol

PubMed ID: 36153373

Doi: 10.1038/s42003-022-03990-w

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mRNA-1273 but not BNT162b2 induces antibodies against polyethylene glycol (PEG) contained in mRNA-based vaccine formulations

Authors: Juan Manuel Carreño, Gagandeep Singh, Johnstone Tcheou, Komal Srivastava, Charles Gleason, Hiromi Muramatsu, Parnavi Desai, Judith A Aberg, Rachel L Miller, Paris Study Group, Norbert Pardi, Viviana Simon, Florian Krammer

Journal: Vaccine

PubMed ID: 36115801

Doi: 10.1016/j.vaccine.2022.08.024

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Disease-associated inosine misincorporation into RNA hinders translation

Authors: Jacob H Schroader, Lindsey A Jones, Ryan Meng, Hannah K Shorrock, Jared I Richardson, Sharon M Shaughnessy, Qishan Lin, Thomas J Begley, J Andrew Berglund, Gabriele Fuchs, Mark T Handley, Kaalak Reddy

Journal: Nucleic Acids Res

PubMed ID: 35979951

Doi: 10.1093/nar/gkac709

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Investigation of the Neutralizing Antibody Response of Healthcare Workers at a Korean University Hospital Six Months After the Introduction of the COVID-19 Vaccine

Authors: Seong-Ho Choi, Ji Young Park, Joung Ha Park, Min-Chul Kim, Oh Joo Kweon, Jin-Won Chung

Journal: Ann Lab Med

PubMed ID: 35470282

Doi: 10.3343/alm.2022.42.5.612

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OsAMT1;1 and OsAMT1;2 Coordinate Root Morphological and Physiological Responses to Ammonium for Efficient Nitrogen Foraging in Rice

Authors: Xiangyu Wu, Xiaoxiao Xie, Shan Yang, Qianyu Yin, Huairong Cao, Xiaonan Dong, Jing Hui, Zhi Liu, Zhongtao Jia, Chuanzao Mao, Lixing Yuan

Journal: Plant&cell physiology

PubMed ID: 35861152

Doi: 10.1093/pcp/pcac104

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Splice-switch oligonucleotide-based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC-driven hepatocellular carcinoma

Authors: Dexter Kai Hao Thng, Tan Boon Toh, Paolo Pigini, Lissa Hooi, Yock Young Dan, Pierce Kah-Hoe Chow, Glenn Kunnath Bonney, Masturah Bte Mohd Abdul Rashid, Ernesto Guccione, Dave Keng Boon Wee, Edward Kai-Hua Chow

Journal: Bioeng Transl Med

PubMed ID: 36684069

Doi: 10.1002/btm2.10363

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A new blocking ELISA for detection of foot-and-mouth disease non-structural protein (NSP) antibodies in a broad host range

Authors: Madhusudan Hosamani, Shreya Gopinath, B P Sreenivasa, Subhasmita Behera, Suresh H Basagoudanavar, Ashok Boora, Durlav P Bora, Pankaj Deka, Veerakyathappa Bhanuprakash, Raj Kumar Singh, Aniket Sanyal, Klaas Weerdmeester, Aldo Dekker

Journal: Appl Microbiol Biotechnol

PubMed ID: 36089639

Doi: 10.1007/s00253-022-12151-2

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Synthetic evolution of herbicide resistance using a T7 RNAP-based random DNA base editor

Authors: Haroon Butt, Jose Luis Moreno Ramirez, Magdy Mahfouz

Journal: Life Sci Alliance

PubMed ID: 36171140

Doi: 10.26508/lsa.202201538

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Body Weight is Inversely Associated with Anti-SARS-CoV-2 Antibody Levels after BNT162b2 mRNA Vaccination in Young and Middle Aged Adults

Authors: Su Youn Nam, Seong Woo Jeon, Deuk Kju Jung, Sung-Jae Heo

Journal: Infect Chemother

PubMed ID: 36196609

Doi: 10.3947/ic.2022.0089

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Co-expression and Interaction of Pax6 with Genes and Proteins of Immunological Surveillance in the Brain of Mice

Authors: Shashank Kumar Maurya, Rajnikant Mishra

Journal: Neurotox Res

PubMed ID: 36069979

Doi: 10.1007/s12640-022-00562-y

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Bombyx mori transcription factor, E74A, beneficially affects BmNPV infection through direct interaction

Authors: Xin Wang, Jun-Li Lv, Shuang Cheng, Zhi-Hao Su, Sheng Qin, Xia Sun, Xu-Dong Tang, Qiu-Ning Liu, Mu-Wang Li, Xue-Yang Wang

Journal: Pest Manag Sci

PubMed ID: 36054174

Doi: 10.1002/ps.7152

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Nanobody-based RFP-dependent Cre recombinase for selective anterograde tracing in RFP-expressing transgenic animals

Authors: Ayumu Inutsuka, Sho Maejima, Hiroyuki Mizoguchi, Ryosuke Kaneko, Rei Nomura, Keiko Takanami, Hirotaka Sakamoto, Tatsushi Onaka

Journal: Commun Biol

PubMed ID: 36114373

Doi: 10.1038/s42003-022-03944-2

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Heterologous Expression and Catalytic Properties of Codon-Optimized Small-Sized Bromelain from MD2 Pineapple

Authors: Rafida Razali, Fikran Aranda Fahrudin, Vijay Kumar Subbiah, Kazufumi Takano, Cahyo Budiman

Journal: Molecules

PubMed ID: 36144767

Doi: 10.3390/molecules27186031

Products & Services: Bacterial Expression

Antigenic characterization of the SARS-CoV-2 Omicron subvariant BA275

Authors: Qian Wang, Sho Iketani, Zhiteng Li, Yicheng Guo, Andre Yanchen Yeh, Michael Liu, Jian Yu, Zizhang Sheng, Yaoxing Huang, Lihong Liu, David D Ho

Journal: Cell Host Microbe

PubMed ID: 36108630

Doi: 10.1016/j.chom.2022.09.002

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Dynamic Actin Filament Traps Mediate Active Diffusion of Vesicular Stomatitis Virus Ribonucleoproteins

Authors: Steven J Moran, Shelby Puckett, David A Ornelles, Jed C Macosko, George Holzwarth, Douglas S Lyles

Journal: J Virol

PubMed ID: 36135365

Doi: 10.1128/jvi.00934-22

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Boosting the Cannabidiol Production in Engineered by Harnessing the Vacuolar Transporter BPT1

Authors: Jie Qiu, Kangxin Hou, Qiang Li, Jialin Chen, Xiwen Li, Hongping Hou, Liqiang Wang, Jia Liu, Qiang Xue, Caixia Wang

Journal: J Agric Food Chem

PubMed ID: 36122349

Doi: 10.1021/acs.jafc.2c05468

Products & Services: Proteins, Expression, Isolation and Analysis

Vaspin Ameliorates Cardiac Remodeling by Suppressing Phosphoinositide 3-Kinase/Protein Kinase B Pathway to Improve Oxidative Stress in Heart Failure Rats

Authors: Mingyue Ji, Yong Li, Yun Liu, Genshan Ma

Journal: J Cardiovasc Pharmacol

PubMed ID: 36067399

Doi: 10.1097/FJC.0000000000001291

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Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish

Authors: Josiah D Zoodsma, Emma J Keegan, Gabrielle R Moody, Ashwin A Bhandiwad, Amalia J Napoli, Harold A Burgess, Lonnie P Wollmuth, Howard I Sirotkin

Journal: Mol Autism

PubMed ID: 36138431

Doi: 10.1186/s13229-022-00516-3

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Development and optimization of biologically contained Marburg virus for high-throughput antiviral screening

Authors: Bert Vanmechelen, Joren Stroobants, Winston Chiu, Lieve Naesens, Joost Schepers, Kurt Vermeire, Piet Maes

Journal: Antiviral Res

PubMed ID: 36183903

Doi: 10.1016/j.antiviral.2022.105426

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Utilization of the Abbott SARS-CoV-2 IgG II Quant Assay To Identify High-Titer Anti-SARS-CoV-2 Neutralizing Plasma against Wild-Type and Variant SARS-CoV-2 Viruses

Authors: Yi-Chan J Lin, David H Evans, Ninette F Robbins, Guillermo Orjuela, Queenie Hu, Reuben Samson, Kento T Abe, Bhavisha Rathod, Karen Colwill, Anne-Claude Gingras, Ashleigh Tuite, Qi-Long Yi, Sheila F O'Brien, Steven J Drews

Journal: Microbiol Spectr

PubMed ID: 36125288

Doi: 10.1128/spectrum.02811-22

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Role of lipopolysaccharide in antimicrobial and cell penetrating peptide membrane interactions probed by deuterium NMR of whole cells

Authors: Sarika Kumari, Michael R Morrow, Valerie Booth

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 36155053

Doi: 10.1016/j.bbamem.2022.184053

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Activated AMP-activated protein kinase prevents hepatic steatosis, oxidative stress and inflammation in primary chicken hepatocytes

Authors: Yao Yao, Longlong Li, Huihui Wang, Ying Yang, Haitian Ma

Journal: Front Physiol

PubMed ID: 36160867

Doi: 10.3389/fphys.2022.974825

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A nuclear import pathway exploited by pathogenic noncoding RNAs

Authors: Junfei Ma, Shachinthaka D Dissanayaka Mudiyanselage, Woong June Park, Mo Wang, Ryuta Takeda, Bin Liu, Ying Wang

Journal: Plant Cell

PubMed ID: 35877068

Doi: 10.1093/plcell/koac210

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ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation

Authors: Haruka Hiraoka, Jiewen Wang, Tadashi Nakano, Yasuhiro Hirano, Shinichi Yamazaki, Yasushi Hiraoka, Tokuko Haraguchi

Journal: FEBS Open Bio

PubMed ID: 36054629

Doi: 10.1002/2211-5463.13480

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The CD4 T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn's disease

Authors: Thomas K Pedersen, Eric M Brown, Damian R Plichta, Joachim Johansen, Shaina W Twardus, Toni M Delorey, Helena Lau, Hera Vlamakis, James J Moon, Ramnik J Xavier, Daniel B Graham

Journal: Immunity

PubMed ID: 36115338

Doi: 10.1016/j.immuni.2022.08.016

Products & Services: Proteins, Expression, Isolation and Analysis

Comprehensive analysis of mitogenome of native Henan pig breeds with 58 worldwide pig breeds

Authors: Menghao Zhang, Chen Zhang, Panyang Hu, Lidan Shi, Mingming Ju, Ben Zhang, Xinjian Li, Xuelei Han, Kejun Wang, Xiuling Li, Ruimin Qiao

Journal: Anim Genet

PubMed ID: 36071602

Doi: 10.1111/age.13261

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PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design

Authors: Jeetendra Kumar Nag, Hodaya Malka, Shoshana Sedley, Priyanga Appasamy, Tatyana Rudina, Tgst Levi, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, Rachel Bar-Shavit

Journal: Mol Cancer Ther

PubMed ID: 36066448

Doi: 10.1158/1535-7163.MCT-21-0946

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Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern

Authors: Peifang Sun, Irene Ramos, Camila H Coelho, Alba Grifoni, Corey A Balinsky, Sindhu Vangeti, Alison Tarke, Nathaniel I Bloom, Vihasi Jani, Silvia J Jakubski, David A Boulifard, Elizabeth Cooper, Carl W Goforth, Jan Marayag, Amethyst Marrone, Edgar Nunez, Lindsey White, Chad K Porter, Victor A Sugiharto, Megan Schilling, Avinash S Mahajan, Charmagne Beckett, Alessandro Sette, Stuart C Sealfon, Shane Crotty, Andrew G Letizia

Journal: iScience

PubMed ID: 36168391

Doi: 10.1016/j.isci.2022.105202

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Overexpression of NDST1 Attenuates Fibrotic Response in Murine Adipose-Derived Stem Cells

Authors: Takayoshi Otsuka, Ho-Man Kan, Timothy D Mason, Lakshmi S Nair, Cato T Laurencin

Journal: Stem Cells Dev

PubMed ID: 35920108

Doi: 10.1089/scd.2022.0053

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Immunoglobulin yolk targeting spike 1, receptor binding domain of spike glycoprotein and nucleocapsid of SARS-CoV-2 blocking RBD-ACE2 binding interaction

Authors: Meliana Eka Saputri, Siti Aisyah Rahmalia Effendi, Rifa Nadila, Syauqi Azzam Fajar, Retno Damajanti Soejoedono, Ekowati Handharyani, Okti Nadia Poetri

Journal: Int Immunopharmacol

PubMed ID: 36183680

Doi: 10.1016/j.intimp.2022.109280

Personalized neoantigen vaccine combined with PD-1 blockade increases CD8+ tissue-resident memory T-cell infiltration in preclinical hepatocellular carcinoma models

Authors: Hengkai Chen, Zhenli Li, Liman Qiu, Xiuqing Dong, Geng Chen, Yingjun Shi, Linsheng Cai, Wenhan Liu,Honghao Ye,Yang Zhou,Jiahe Ouyang, Zhixiong Cai and Xiaolong Liu

Journal: J Immunother Cancer

PubMed ID: 36113894

Doi: 10.1136/jitc-2021-004389

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Gas Chromatography-Mass Spectrometry Metabolite Analysis Combined with Transcriptomic and Proteomic Provide New Insights into Revealing Cuticle Formation during Pepper Development

Authors: Shuai Ge, Keying Qin, Shenghua Ding, Jianfeng Yang, Liwen Jiang, Yeyou Qin, Rongrong Wang

Journal: J Agric Food Chem

PubMed ID: 36148491

Doi: 10.1021/acs.jafc.2c04522

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Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism

Authors: Ni Liu, Xiaohan Liang, Changwen Yang, Shun Hu, Qingming Luo, Haiming Luo

Journal: Theranostics

PubMed ID: 36185606

Doi: 10.7150/thno.76574

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Evaluation of Immunogenicity to Three Doses of the SARS-CoV-2 BNT162b2 mRNA Vaccine in Lung Transplant Patients

Authors: Mariasilvia Guardiani, Maria Antonella Zingaropoli, Francesco Cogliati Dezza, Anastasia Centofanti, Carolina Carillo, Eeva Tortellini, Federica Dominelli, Anna Napoli, Cosmo Del Borgo, Aurelia Gaeta, Federico Venuta, Vincenzo Vullo, Miriam Lichtner, Maria Rosa Ciardi, Claudio Maria Mastroianni, Gianluca Russo

Journal: Vaccines (Basel)

PubMed ID: 36298507

Doi: 10.3390/vaccines10101642

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Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca/calmodulin-dependent CaMKIIα activity in mutations related to intellectual disability

Authors: Hajime Fujii, Hiroyuki Kidokoro, Yayoi Kondo, Masahiro Kawaguchi, Shin-Ichiro Horigane, Jun Natsume, Sayaka Takemoto-Kimura, Haruhiko Bito

Journal: Front Mol Neurosci

PubMed ID: 36117912

Doi: 10.3389/fnmol.2022.970031

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BT8009; a Nectin-4 targeting Bicycle® Toxin Conjugate for treatment of solid tumors

Authors: Michael Rigby, Gavin Bennett, Liuhong Chen, Gemma E Mudd, Helen Harrison, Paul J Beswick, Katerine van Rietschoten, Sophie M Watcham, Heather S Scott, Amy N Brown, Peter U Park, Carly Campbell, Eric Haines, Johanna Lahdenranta, Michael J Skynner, Phil Jeffrey, Nicholas Keen, Kevin Lee

Journal: Mol Cancer Ther

PubMed ID: 36112771

Doi: 10.1158/1535-7163.MCT-21-0875

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Toll-like receptor 4 signaling pathway mediates both liver and kidney injuries in mice with hepatorenal syndrome

Authors: Mingliang Wang, Tingting Qin, Yunyun Zhang, Ting Zhang, Zirui Zhuang, Yingyu Wang, Yongfang Ding, Yunru Peng

Journal: Am J Physiol Gastrointest Liver Physiol

PubMed ID: 36165507

Doi: 10.1152/ajpgi.00048.2022

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Stacking herbicide detoxification and resistant genes improves glyphosate tolerance and reduces phytotoxicity in tobacco (Nicotiana tabacum L) and rice (Oryza sativa L)

Authors: Amaranatha Reddy Vennapusa, Subham Agarwal, Hanumanth Rao Hm, Thiagarayaselvam Aarthy, K C Babitha, Hirekodathakallu V Thulasiram, Mahesh J Kulkarni, Kalpalatha Melmaiee, Chinta Sudhakar, M Udayakumar, Ramu S Vemanna

Journal: Plant Physiol Biochem

PubMed ID: 36084528

Doi: 10.1016/j.plaphy.2022.08.025

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Small molecule quercetin binds triplex and modulates its cellular function

Authors: Isha Rakheja, Asgar Hussain Ansari, Arjun Ray, Dheeraj Chandra Joshi, Souvik Maiti

Journal: Mol Ther Nucleic Acids

PubMed ID: 36284512

Doi: 10.1016/j.omtn.2022.09.016

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Rational design of photosynthetic reaction center protein maquettes

Authors: Nathan M Ennist, Steven E Stayrook, P Leslie Dutton, Christopher C Moser

Journal: Front Mol Biosci

PubMed ID: 36213121

Doi: 10.3389/fmolb.2022.997295

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Heat Shock Protein 60 Is Involved in Viral Replication Complex Formation and Facilitates Foot and Mouth Virus Replication by Stabilizing Viral Nonstructural Proteins 3A and 2C

Authors: Jianli Tang, Sahibzada Waheed Abdullah, Pinghua Li, Jin'en Wu, Chenchen Pei, Suyu Mu, Yunlu Wang, Shiqi Sun, Huichen Guo

Journal: MBio

PubMed ID: 36106732

Doi: 10.1128/mbio.01434-22

Products & Services: Proteins, Expression, Isolation and Analysis

Protein Tyrosine Phosphatase Receptor Type R (PTPRR) Reduces AChR Clustering by Dephosphorylating MuSK

Authors: Yanxun Chen, Maohao Guan, Fengqiang Yu, Zhongshan Yang, Weiqiang Yi, Xuan Huang, Ruiqin Qiu, Fancai Lai

Journal: Dis Markers

PubMed ID: 36105254

Doi: 10.1155/2022/5160624

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Development of a highly sensitive Gaussia luciferase immunoprecipitation assay for the detection of antibodies against African swine fever virus

Authors: Jingjing Ding, Jifei Yang, Daoyuan Jiang, Yanyang Zhou, Chenxi Li, Yanhua Li

Journal: Front Cell Infect Microbiol

PubMed ID: 36189357

Doi: 10.3389/fcimb.2022.988355

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RAB3D, upregulated by aryl hydrocarbon receptor (AhR), promotes the progression of prostate cancer by activating the PI3K/AKT signaling pathway

Authors: Jingsong Yu, Haipeng Qi, Zheng Wang, Ze Zhang, Erlin Song, Wenting Song, Ruihua An

Journal: Cell Biol Int

PubMed ID: 36153645

Doi: 10.1002/cbin.11910

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Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

Authors: Eric S Pringle, Brett A Duguay, Maxwell P Bui-Marinos, Rory P Mulloy, Shelby L Landreth, Krishna Swaroop Desireddy, Stacia M Dolliver, Shan Ying, Taylor Caddell, Trinity H Tooley, Patrick D Slaine, Stephen L Bearne, Darryl Falzarano, Jennifer A Corcoran, Denys A Khaperskyy, Craig McCormick

Journal: PLoS Pathog

PubMed ID: 36121863

Doi: 10.1371/journal.ppat.1010832

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D121 Located within the DRY Motif of P2Y12 Is Essential for P2Y12-Mediated Platelet Function

Authors: Carol Dangelmaier, Benjamin Mauri, Akruti Patel, Satya P Kunapuli, John C Kostyak

Journal: Int J Mol Sci

PubMed ID: 36232816

Doi: 10.3390/ijms231911519

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Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein

Authors: Kailu Yang, Chuchu Wang, Alex J B Kreutzberger, Ravi Ojha, Suvi Kuivanen, Sergio Couoh-Cardel, Serena Muratcioglu, Timothy J Eisen, K Ian White, Richard G Held, Subu Subramanian, Kendra Marcus, Richard A Pfuetzner, Luis Esquivies, Catherine A Doyle, John Kuriyan, Olli Vapalahti, Giuseppe Balistreri, Tom Kirchhausen, Axel T Brunger

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36122200

Doi: 10.1073/pnas.2210990119

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Vaccine target and carrier molecule nontypeable Haemophilus influenzae protein D dimerizes like the close Escherichia coli GlpQ homolog but unlike other known homolog dimers

Authors: Seth P Jones, Kali H Cook, Melody L Holmquist, Liam J Almekinder, Annie M Delaney, Ryhl Charles, Natalie Labbe, Janai Perdue, Niaya Jackson, Michael E Pichichero, Ravinder Kaur, Lea V Michel, Michael L Gleghorn

Journal: Proteins

PubMed ID: 36065600

Doi: 10.1002/prot.26418

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Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens

Authors: Matheus Oliveira de Souza, Bharat Madan, I-Ting Teng, Aric Huang, Lihong Liu, Ahmed S Fahad, Sheila N Lopez Acevedo, Xiaoli Pan, Mallika Sastry, Matias Gutierrez-Gonzalez, Michael T Yin, Tongqing Zhou, David D Ho, Peter D Kwong, Brandon J DeKosky

Journal: Front Immunol

PubMed ID: 36119018

Doi: 10.3389/fimmu.2022.977064

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Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening

Authors: Peter C DeWeirdt, Abby V McGee, Fengyi Zheng, Ifunanya Nwolah, Mudra Hegde, John G Doench

Journal: Nat Commun

PubMed ID: 36068235

Doi: 10.1038/s41467-022-33024-2

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A recombinant subunit vaccine candidate produced in plants elicits neutralizing antibodies against SARS-CoV-2 variants in macaques

Authors: Narach Khorattanakulchai, Kanjana Srisutthisamphan, Balamurugan Shanmugaraj, Suwimon Manopwisedjaroen, Kaewta Rattanapisit, Chalisa Panapitakkul, Taratorn Kemthong, Nutchanat Suttisan, Suchinda Malaivijitnond, Arunee Thitithanyanont, Anan Jongkaewwattana, Waranyoo Phoolcharoen

Journal: Front Plant Sci

PubMed ID: 36247553

Doi: 10.3389/fpls.2022.901978

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Chemoenzymatic Synthesis of SARS-CoV-2 Homogeneous O-Linked Glycopeptides for Exploring Their Inhibition Functions

Authors: Yongheng Rong, Xingyun Wang, Weian Mao, Fang Yuan, Min Chen, Shengjun Wang, Peng George Wang, Zhigang Wu, Yunjiao He, Yun Kong

Journal: ACS Infect Dis

PubMed ID: 36095241

Doi: 10.1021/acsinfecdis.2c00383

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Herpes Simplex Virus 1 Glycoproteins Differentially Regulate the Activity of Costimulatory Molecules and T Cells

Authors: Harry H Matundan, Ujjaldeep Jaggi, Homayon Ghiasi

Journal: mSphere

PubMed ID: 36094100

Doi: 10.1128/msphere.00382-22

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A 1-aminocyclopropane-1-carboxylic-acid (ACC) dipeptide elicits ethylene responses through ACC-oxidase mediated substrate promiscuity

Authors: John Vaughan-Hirsch, Dongdong Li, Albert Roig Martinez, Stijn Roden, Jolien Pattyn, Shu Taira, Hitomi Shikano, Yoko Miyama, Yukari Okano, Arnout Voet, Bram Van de Poel

Journal: Front Plant Sci

PubMed ID: 36172554

Doi: 10.3389/fpls.2022.995073

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Treatment of Sindbis Virus-Infected Neurons with Antibody to E2 Alters Synthesis of Complete and nsP1-Expressing Defective Viral RNAs

Authors: Jane X Yeh, Yunfan Fan, Maggie L Bartlett, Xiaoyan Zhang, Norah Sadowski, Debra A Hauer, Winston Timp, Diane E Griffin

Journal: MBio

PubMed ID: 36069441

Doi: 10.1128/mbio.02221-22

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Evasion of neutralizing antibody responses by the SARS-CoV-2 BA275 variant

Authors: Panke Qu, John P Evans, Yi-Min Zheng, Claire Carlin, Linda J Saif, Eugene M Oltz, Kai Xu, Richard J Gumina, Shan-Lu Liu

Journal: Cell Host Microbe

PubMed ID: 36240764

Doi: 10.1016/j.chom.2022.09.015

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Selection and characterization of bispecific aptamers against malachite green and leucomalachite green

Authors: Wenwei Wu, Qifeng Sun, Tiansong Li, Kexin Liu, Yan Jiang, Yi Wang, Yongjie Yang

Journal: Anal Biochem

PubMed ID: 36150472

Doi: 10.1016/j.ab.2022.114849

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Fatty acid binding protein is required for chitin biosynthesis in the wing of Drosophila melanogaster

Authors: Jiqiang Chen, Xu Zou, Weixing Zhu, Yanwei Duan, Hans Merzendorfer, Zhangwu Zhao, Qing Yang

Journal: Insect Biochem Mol Biol

PubMed ID: 36165873

Doi: 10.1016/j.ibmb.2022.103845

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Seed-Based System for Cost-Effective Production of Vaccine Against Chronic Respiratory Disease in Chickens

Authors: Yao Shi, Peyman Habibi, Ayesha Naveed Ul Haq, Madiha Saeed, Namra Gulghutay Amjad, Imran Khan

Journal: Mol Biotechnol

PubMed ID: 36087216

Doi: 10.1007/s12033-022-00554-5

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SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins

Authors: Museer A Lone, Mari J Aaltonen, Aliza Zidell, Helio F Pedro, Jonas A Morales Saute, Shalett Mathew, Payam Mohassel, Carsten G Bönnemann, Eric A Shoubridge, Thorsten Hornemann

Journal: J Clin Invest

PubMed ID: 35900868

Doi: 10.1172/JCI161908

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Lymphocyte Subpopulations Associated with Neutralizing Antibody Levels of SARS-CoV-2 for COVID-19 Vaccination

Authors: Wan-Ting Huang, Shao-Wen Weng, Hong-Tai Tzeng, Feng-Chun Yen, Yu-Shao Chiang, Huey-Ling You

Journal: Vaccines (Basel)

PubMed ID: 36146627

Doi: 10.3390/vaccines10091550

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