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Comprehensive analysis of mitogenome of native Henan pig breeds with 58 worldwide pig breeds

Authors: Menghao Zhang, Chen Zhang, Panyang Hu, Lidan Shi, Mingming Ju, Ben Zhang, Xinjian Li, Xuelei Han, Kejun Wang, Xiuling Li, Ruimin Qiao

Journal: Anim Genet

PubMed ID: 36071602

Doi: 10.1111/age.13261

Products & Services: DNA Sequencing

PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design

Authors: Jeetendra Kumar Nag, Hodaya Malka, Shoshana Sedley, Priyanga Appasamy, Tatyana Rudina, Tgst Levi, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, Rachel Bar-Shavit

Journal: Mol Cancer Ther

PubMed ID: 36066448

Doi: 10.1158/1535-7163.MCT-21-0946

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Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern

Authors: Peifang Sun, Irene Ramos, Camila H Coelho, Alba Grifoni, Corey A Balinsky, Sindhu Vangeti, Alison Tarke, Nathaniel I Bloom, Vihasi Jani, Silvia J Jakubski, David A Boulifard, Elizabeth Cooper, Carl W Goforth, Jan Marayag, Amethyst Marrone, Edgar Nunez, Lindsey White, Chad K Porter, Victor A Sugiharto, Megan Schilling, Avinash S Mahajan, Charmagne Beckett, Alessandro Sette, Stuart C Sealfon, Shane Crotty, Andrew G Letizia

Journal: iScience

PubMed ID: 36168391

Doi: 10.1016/j.isci.2022.105202

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Overexpression of NDST1 Attenuates Fibrotic Response in Murine Adipose-Derived Stem Cells

Authors: Takayoshi Otsuka, Ho-Man Kan, Timothy D Mason, Lakshmi S Nair, Cato T Laurencin

Journal: Stem Cells Dev

PubMed ID: 35920108

Doi: 10.1089/scd.2022.0053

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Immunoglobulin yolk targeting spike 1, receptor binding domain of spike glycoprotein and nucleocapsid of SARS-CoV-2 blocking RBD-ACE2 binding interaction

Authors: Meliana Eka Saputri, Siti Aisyah Rahmalia Effendi, Rifa Nadila, Syauqi Azzam Fajar, Retno Damajanti Soejoedono, Ekowati Handharyani, Okti Nadia Poetri

Journal: Int Immunopharmacol

PubMed ID: 36183680

Doi: 10.1016/j.intimp.2022.109280

Personalized neoantigen vaccine combined with PD-1 blockade increases CD8+ tissue-resident memory T-cell infiltration in preclinical hepatocellular carcinoma models

Authors: Hengkai Chen, Zhenli Li, Liman Qiu, Xiuqing Dong, Geng Chen, Yingjun Shi, Linsheng Cai, Wenhan Liu,Honghao Ye,Yang Zhou,Jiahe Ouyang, Zhixiong Cai and Xiaolong Liu

Journal: J Immunother Cancer

PubMed ID: 36113894

Doi: 10.1136/jitc-2021-004389

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Gas Chromatography-Mass Spectrometry Metabolite Analysis Combined with Transcriptomic and Proteomic Provide New Insights into Revealing Cuticle Formation during Pepper Development

Authors: Shuai Ge, Keying Qin, Shenghua Ding, Jianfeng Yang, Liwen Jiang, Yeyou Qin, Rongrong Wang

Journal: J Agric Food Chem

PubMed ID: 36148491

Doi: 10.1021/acs.jafc.2c04522

Products & Services: Proteins, Expression, Isolation and Analysis

Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism

Authors: Ni Liu, Xiaohan Liang, Changwen Yang, Shun Hu, Qingming Luo, Haiming Luo

Journal: Theranostics

PubMed ID: 36185606

Doi: 10.7150/thno.76574

Products & Services: Proteins, Expression, Isolation and Analysis

Evaluation of Immunogenicity to Three Doses of the SARS-CoV-2 BNT162b2 mRNA Vaccine in Lung Transplant Patients

Authors: Mariasilvia Guardiani, Maria Antonella Zingaropoli, Francesco Cogliati Dezza, Anastasia Centofanti, Carolina Carillo, Eeva Tortellini, Federica Dominelli, Anna Napoli, Cosmo Del Borgo, Aurelia Gaeta, Federico Venuta, Vincenzo Vullo, Miriam Lichtner, Maria Rosa Ciardi, Claudio Maria Mastroianni, Gianluca Russo

Journal: Vaccines (Basel)

PubMed ID: 36298507

Doi: 10.3390/vaccines10101642

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Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca/calmodulin-dependent CaMKIIα activity in mutations related to intellectual disability

Authors: Hajime Fujii, Hiroyuki Kidokoro, Yayoi Kondo, Masahiro Kawaguchi, Shin-Ichiro Horigane, Jun Natsume, Sayaka Takemoto-Kimura, Haruhiko Bito

Journal: Front Mol Neurosci

PubMed ID: 36117912

Doi: 10.3389/fnmol.2022.970031

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BT8009; a Nectin-4 targeting Bicycle® Toxin Conjugate for treatment of solid tumors

Authors: Michael Rigby, Gavin Bennett, Liuhong Chen, Gemma E Mudd, Helen Harrison, Paul J Beswick, Katerine van Rietschoten, Sophie M Watcham, Heather S Scott, Amy N Brown, Peter U Park, Carly Campbell, Eric Haines, Johanna Lahdenranta, Michael J Skynner, Phil Jeffrey, Nicholas Keen, Kevin Lee

Journal: Mol Cancer Ther

PubMed ID: 36112771

Doi: 10.1158/1535-7163.MCT-21-0875

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Toll-like receptor 4 signaling pathway mediates both liver and kidney injuries in mice with hepatorenal syndrome

Authors: Mingliang Wang, Tingting Qin, Yunyun Zhang, Ting Zhang, Zirui Zhuang, Yingyu Wang, Yongfang Ding, Yunru Peng

Journal: Am J Physiol Gastrointest Liver Physiol

PubMed ID: 36165507

Doi: 10.1152/ajpgi.00048.2022

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Stacking herbicide detoxification and resistant genes improves glyphosate tolerance and reduces phytotoxicity in tobacco (Nicotiana tabacum L) and rice (Oryza sativa L)

Authors: Amaranatha Reddy Vennapusa, Subham Agarwal, Hanumanth Rao Hm, Thiagarayaselvam Aarthy, K C Babitha, Hirekodathakallu V Thulasiram, Mahesh J Kulkarni, Kalpalatha Melmaiee, Chinta Sudhakar, M Udayakumar, Ramu S Vemanna

Journal: Plant Physiol Biochem

PubMed ID: 36084528

Doi: 10.1016/j.plaphy.2022.08.025

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Small molecule quercetin binds triplex and modulates its cellular function

Authors: Isha Rakheja, Asgar Hussain Ansari, Arjun Ray, Dheeraj Chandra Joshi, Souvik Maiti

Journal: Mol Ther Nucleic Acids

PubMed ID: 36284512

Doi: 10.1016/j.omtn.2022.09.016

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Rational design of photosynthetic reaction center protein maquettes

Authors: Nathan M Ennist, Steven E Stayrook, P Leslie Dutton, Christopher C Moser

Journal: Front Mol Biosci

PubMed ID: 36213121

Doi: 10.3389/fmolb.2022.997295

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Heat Shock Protein 60 Is Involved in Viral Replication Complex Formation and Facilitates Foot and Mouth Virus Replication by Stabilizing Viral Nonstructural Proteins 3A and 2C

Authors: Jianli Tang, Sahibzada Waheed Abdullah, Pinghua Li, Jin'en Wu, Chenchen Pei, Suyu Mu, Yunlu Wang, Shiqi Sun, Huichen Guo

Journal: MBio

PubMed ID: 36106732

Doi: 10.1128/mbio.01434-22

Products & Services: Proteins, Expression, Isolation and Analysis

Protein Tyrosine Phosphatase Receptor Type R (PTPRR) Reduces AChR Clustering by Dephosphorylating MuSK

Authors: Yanxun Chen, Maohao Guan, Fengqiang Yu, Zhongshan Yang, Weiqiang Yi, Xuan Huang, Ruiqin Qiu, Fancai Lai

Journal: Dis Markers

PubMed ID: 36105254

Doi: 10.1155/2022/5160624

Products & Services: Proteins, Expression, Isolation and Analysis

Development of a highly sensitive Gaussia luciferase immunoprecipitation assay for the detection of antibodies against African swine fever virus

Authors: Jingjing Ding, Jifei Yang, Daoyuan Jiang, Yanyang Zhou, Chenxi Li, Yanhua Li

Journal: Front Cell Infect Microbiol

PubMed ID: 36189357

Doi: 10.3389/fcimb.2022.988355

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RAB3D, upregulated by aryl hydrocarbon receptor (AhR), promotes the progression of prostate cancer by activating the PI3K/AKT signaling pathway

Authors: Jingsong Yu, Haipeng Qi, Zheng Wang, Ze Zhang, Erlin Song, Wenting Song, Ruihua An

Journal: Cell Biol Int

PubMed ID: 36153645

Doi: 10.1002/cbin.11910

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Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

Authors: Eric S Pringle, Brett A Duguay, Maxwell P Bui-Marinos, Rory P Mulloy, Shelby L Landreth, Krishna Swaroop Desireddy, Stacia M Dolliver, Shan Ying, Taylor Caddell, Trinity H Tooley, Patrick D Slaine, Stephen L Bearne, Darryl Falzarano, Jennifer A Corcoran, Denys A Khaperskyy, Craig McCormick

Journal: PLoS Pathog

PubMed ID: 36121863

Doi: 10.1371/journal.ppat.1010832

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D121 Located within the DRY Motif of P2Y12 Is Essential for P2Y12-Mediated Platelet Function

Authors: Carol Dangelmaier, Benjamin Mauri, Akruti Patel, Satya P Kunapuli, John C Kostyak

Journal: Int J Mol Sci

PubMed ID: 36232816

Doi: 10.3390/ijms231911519

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Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein

Authors: Kailu Yang, Chuchu Wang, Alex J B Kreutzberger, Ravi Ojha, Suvi Kuivanen, Sergio Couoh-Cardel, Serena Muratcioglu, Timothy J Eisen, K Ian White, Richard G Held, Subu Subramanian, Kendra Marcus, Richard A Pfuetzner, Luis Esquivies, Catherine A Doyle, John Kuriyan, Olli Vapalahti, Giuseppe Balistreri, Tom Kirchhausen, Axel T Brunger

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36122200

Doi: 10.1073/pnas.2210990119

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Vaccine target and carrier molecule nontypeable Haemophilus influenzae protein D dimerizes like the close Escherichia coli GlpQ homolog but unlike other known homolog dimers

Authors: Seth P Jones, Kali H Cook, Melody L Holmquist, Liam J Almekinder, Annie M Delaney, Ryhl Charles, Natalie Labbe, Janai Perdue, Niaya Jackson, Michael E Pichichero, Ravinder Kaur, Lea V Michel, Michael L Gleghorn

Journal: Proteins

PubMed ID: 36065600

Doi: 10.1002/prot.26418

Products & Services: Proteins, Expression, Isolation and Analysis

Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens

Authors: Matheus Oliveira de Souza, Bharat Madan, I-Ting Teng, Aric Huang, Lihong Liu, Ahmed S Fahad, Sheila N Lopez Acevedo, Xiaoli Pan, Mallika Sastry, Matias Gutierrez-Gonzalez, Michael T Yin, Tongqing Zhou, David D Ho, Peter D Kwong, Brandon J DeKosky

Journal: Front Immunol

PubMed ID: 36119018

Doi: 10.3389/fimmu.2022.977064

Products & Services: Proteins, Expression, Isolation and Analysis

Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening

Authors: Peter C DeWeirdt, Abby V McGee, Fengyi Zheng, Ifunanya Nwolah, Mudra Hegde, John G Doench

Journal: Nat Commun

PubMed ID: 36068235

Doi: 10.1038/s41467-022-33024-2

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A recombinant subunit vaccine candidate produced in plants elicits neutralizing antibodies against SARS-CoV-2 variants in macaques

Authors: Narach Khorattanakulchai, Kanjana Srisutthisamphan, Balamurugan Shanmugaraj, Suwimon Manopwisedjaroen, Kaewta Rattanapisit, Chalisa Panapitakkul, Taratorn Kemthong, Nutchanat Suttisan, Suchinda Malaivijitnond, Arunee Thitithanyanont, Anan Jongkaewwattana, Waranyoo Phoolcharoen

Journal: Front Plant Sci

PubMed ID: 36247553

Doi: 10.3389/fpls.2022.901978

Products & Services: Proteins, Expression, Isolation and Analysis

Chemoenzymatic Synthesis of SARS-CoV-2 Homogeneous O-Linked Glycopeptides for Exploring Their Inhibition Functions

Authors: Yongheng Rong, Xingyun Wang, Weian Mao, Fang Yuan, Min Chen, Shengjun Wang, Peng George Wang, Zhigang Wu, Yunjiao He, Yun Kong

Journal: ACS Infect Dis

PubMed ID: 36095241

Doi: 10.1021/acsinfecdis.2c00383

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Herpes Simplex Virus 1 Glycoproteins Differentially Regulate the Activity of Costimulatory Molecules and T Cells

Authors: Harry H Matundan, Ujjaldeep Jaggi, Homayon Ghiasi

Journal: mSphere

PubMed ID: 36094100

Doi: 10.1128/msphere.00382-22

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A 1-aminocyclopropane-1-carboxylic-acid (ACC) dipeptide elicits ethylene responses through ACC-oxidase mediated substrate promiscuity

Authors: John Vaughan-Hirsch, Dongdong Li, Albert Roig Martinez, Stijn Roden, Jolien Pattyn, Shu Taira, Hitomi Shikano, Yoko Miyama, Yukari Okano, Arnout Voet, Bram Van de Poel

Journal: Front Plant Sci

PubMed ID: 36172554

Doi: 10.3389/fpls.2022.995073

Products & Services: Proteins, Expression, Isolation and Analysis

Treatment of Sindbis Virus-Infected Neurons with Antibody to E2 Alters Synthesis of Complete and nsP1-Expressing Defective Viral RNAs

Authors: Jane X Yeh, Yunfan Fan, Maggie L Bartlett, Xiaoyan Zhang, Norah Sadowski, Debra A Hauer, Winston Timp, Diane E Griffin

Journal: MBio

PubMed ID: 36069441

Doi: 10.1128/mbio.02221-22

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Evasion of neutralizing antibody responses by the SARS-CoV-2 BA275 variant

Authors: Panke Qu, John P Evans, Yi-Min Zheng, Claire Carlin, Linda J Saif, Eugene M Oltz, Kai Xu, Richard J Gumina, Shan-Lu Liu

Journal: Cell Host Microbe

PubMed ID: 36240764

Doi: 10.1016/j.chom.2022.09.015

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Selection and characterization of bispecific aptamers against malachite green and leucomalachite green

Authors: Wenwei Wu, Qifeng Sun, Tiansong Li, Kexin Liu, Yan Jiang, Yi Wang, Yongjie Yang

Journal: Anal Biochem

PubMed ID: 36150472

Doi: 10.1016/j.ab.2022.114849

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Fatty acid binding protein is required for chitin biosynthesis in the wing of Drosophila melanogaster

Authors: Jiqiang Chen, Xu Zou, Weixing Zhu, Yanwei Duan, Hans Merzendorfer, Zhangwu Zhao, Qing Yang

Journal: Insect Biochem Mol Biol

PubMed ID: 36165873

Doi: 10.1016/j.ibmb.2022.103845

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Seed-Based System for Cost-Effective Production of Vaccine Against Chronic Respiratory Disease in Chickens

Authors: Yao Shi, Peyman Habibi, Ayesha Naveed Ul Haq, Madiha Saeed, Namra Gulghutay Amjad, Imran Khan

Journal: Mol Biotechnol

PubMed ID: 36087216

Doi: 10.1007/s12033-022-00554-5

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SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins

Authors: Museer A Lone, Mari J Aaltonen, Aliza Zidell, Helio F Pedro, Jonas A Morales Saute, Shalett Mathew, Payam Mohassel, Carsten G Bönnemann, Eric A Shoubridge, Thorsten Hornemann

Journal: J Clin Invest

PubMed ID: 35900868

Doi: 10.1172/JCI161908

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Lymphocyte Subpopulations Associated with Neutralizing Antibody Levels of SARS-CoV-2 for COVID-19 Vaccination

Authors: Wan-Ting Huang, Shao-Wen Weng, Hong-Tai Tzeng, Feng-Chun Yen, Yu-Shao Chiang, Huey-Ling You

Journal: Vaccines (Basel)

PubMed ID: 36146627

Doi: 10.3390/vaccines10091550

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Function identification and characterization of ZRT and IRT-like proteins computationally for nutrition and biofortification in rice

Authors: Khaled Fathy Abdelmotelb Mohammed, Tanushri Kaul, Pawan Kumar Agrawal, Arulprakash Thangaraj, Rashmi Kaul, Sudhir K Sopory

Journal: J Biomol Struct Dyn

PubMed ID: 36111599

Doi: 10.1080/07391102.2022.2118169

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Single-chain insulin analogs threaded by the insulin receptor αCT domain

Authors: Nicholas A Smith, John G Menting, Michael A Weiss, Michael C Lawrence, Brian J Smith

Journal: Biophys J

PubMed ID: 36181268

Doi: 10.1016/j.bpj.2022.09.038

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Identification of a UDP-glucosyltransferase conferring deoxynivalenol resistance in Aegilops tauschii and wheat

Authors: Rizky Pasthika Kirana, Kumar Gaurav, Sanu Arora, Gerlinde Wiesenberger, Maria Doppler, Sebastian Michel, Simone Zimmerl, Magdalena Matic, Chinedu E Eze, Mukesh Kumar, Ajla Topuz, Marc Lemmens, Rainer Schuhmacher, Gerhard Adam, Brande B H Wulff, Hermann Buerstmayr, Barbara Steiner

Journal: Plant Biotechnol J

PubMed ID: 36121345

Doi: 10.1111/pbi.13928

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A Cephalosporin-Tripodalamine Conjugate Inhibits Metallo-β-Lactamase with High Efficacy and Low Toxicity

Authors: Hongyan Tian, Yiwan Wang, Yang Dai, Anwen Mao, Wanqing Zhou, Xiaoli Cao, Hui Deng, Hao Lu, Lin Ding, Han Shen, Xiaojian Wang

Journal: Antimicrob Agents Chemother

PubMed ID: 36094199

Doi: 10.1128/aac.00352-22

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Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors

Authors: Hadar Cohen, Noam Baram, Chaya Mushka Fridman, Liat Edry-Botzer, Dor Salomon, Motti Gerlic

Journal: Elife

PubMed ID: 36155655

Doi: 10.7554/eLife.82766

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Acetylation of Atp5f1c Mediates Cardiomyocyte Senescence via Metabolic Dysfunction in Radiation-Induced Heart Damage

Authors: Zhimin Zeng, Peng Xu, Yanqing He, Yali Yi, Zhicheng Liu, Jing Cai, Long Huang, Anwen Liu

Journal: Oxid Med Cell Longev

PubMed ID: 36160705

Doi: 10.1155/2022/4155565

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The gene regulates dimorphic sexual and aggressive behaviors in

Authors: Caihong Han, Qionglin Peng, Mengshi Sun, Xinyu Jiang, Xiangbin Su, Jiangtao Chen, Mingze Ma, Huan Zhu, Xiaoxiao Ji, Yufeng Pan

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36067320

Doi: 10.1073/pnas.2201513119

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A megadiverse naïve library derived from numerous camelids for efficient and rapid development of VHH antibodies

Authors: Meiniang Wang, Likun Wei, Haitao Xiang, Bingzhao Ren, Xiaopan Liu, Lin Jiang, Naibo Yang, Jiahai Shi

Journal: Anal Biochem

PubMed ID: 36108795

Doi: 10.1016/j.ab.2022.114871

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A gain-of-function filamin A mutation in mouse platelets induces thrombus instability

Authors: Frédéric Adam, Alexandre Kauskot, Lamia Lamrani, Jean Solarz, Christelle Soukaseum, Christelle Repérant, Cécile V Denis, Hana Raslova, Jean-Philippe Rosa, Marijke Bryckaert

Journal: J Thromb Haemost

PubMed ID: 36006037

Doi: 10.1111/jth.15864

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Immunogenicity after a Third COVID-19 mRNA Booster in Solid Cancer Patients Who Previously Received the Primary Heterologous CoronaVac/ChAdOx1 Vaccine

Authors: Sutima Luangdilok, Passakorn Wanchaijiraboon, Nussara Pakvisal, Thiti Susiriwatananont, Nicha Zungsontiporn, Virote Sriuranpong, Panot Sainamthip, Nungruthai Suntronwong, Preeyaporn Vichaiwattana, Nasamon Wanlapakorn, Yong Poovorawan, Nattaya Teeyapun, Suebpong Tanasanvimon

Journal: Vaccines (Basel)

PubMed ID: 36298478

Doi: 10.3390/vaccines10101613

The plant nucleoplasmin AtFKBP43 needs its extended arms for histone interaction

Authors: Ajit Kumar Singh, Ketul Saharan, Somanath Baral, Dileep Vasudevan

Journal: Biochim Biophys Acta Gene Regul Mech

PubMed ID: 36058470

Doi: 10.1016/j.bbagrm.2022.194872

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Recombinase polymerase amplification-lateral flow dipstick assay for rapid detection of Fusarium circinatum based on a newly identified unique target gene

Authors: Jieying Xu , Xiao Yang , Cuiping Wu , Zhenpeng Chen , Tingting Dai

Journal: Plant Dis

PubMed ID: 36089688

Doi: 10.1094/PDIS-04-22-0864-RE

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GAGE is a method for identification of plant species based on whole genome analysis and genome editing

Authors: Lijun Hao , Wenjie Xu , Guihong Qi , Tianyi Xin , Zhichao Xu , Hetian Lei , Jingyuan Song

Journal: Commun Biol

PubMed ID: 36088518

Doi: 10.1038/s42003-022-03894-9

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Structural and large-scale analysis unveil the intertwined paths promoting NMT-catalyzed lysine and glycine myristoylation

Authors: Frédéric Rivière , Cyril Dian , Rémi F Dutheil , Paul Monassa , Carmela Giglione , Thierry Meinnel

Journal: J Mol Biol

PubMed ID: 36181773

Doi: 10.1016/j.jmb.2022.167843

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Phosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy

Authors: Qi Yu , Xuanyunjing Gong , Yue Tong , Min Wang , Kai Duan , Xinyu Zhang , Feng Ge , Xilan Yu , Shanshan Li

Journal: NaCommunt

PubMed ID: 36167807

Doi: 10.1038/s41467-022-33423-5

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Hydrophobic cell surface display system of PETase as a sustainable biocatalyst for PET degradation

Authors: Yunpu Jia , Nadia A Samak , Xuemi Hao , Zheng Chen , Qifeng Wen , Jianmin Xing

Journal: Front Microbiol

PubMed ID: 36246227

Doi: 10.3389/fmicb.2022.1005480

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The sequestration mechanism as a generalizable approach to improve the sensitivity of biosensors and bioassays

Authors: Alejandro Chamorro-Garcia , Claudio Parolo , Gabriel Ortega , Andrea Idili , Joshua Green , Francesco Ricci , Kevin W Plaxco

Journal: Chem Sci

PubMed ID: 36349092

Doi: 10.1039/d2sc03901j

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Lentiviral vector mediated gene therapy for type I Dent disease ameliorates Dent disease-like phenotypes for three months in ClC-5 null mice

Authors: Manish Kumar Yadav , Kyung Whan Yoo , Anthony Atala , Baisong Lu

Journal: Mol Ther Methods Clin Dev

PubMed ID: 36284768

Doi: 10.1016/j.omtm.2022.09.009

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Cross-reactivity between vaccine antigens from the chitin deacetylase protein family improves survival in a mouse model of cryptococcosis

Authors: Maureen M Hester, Lorena V N Oliveira, Ruiying Wang, Zhongming Mou, Diana Lourenco, Gary R Ostroff, Charles A Specht, Stuart M Levitz

Journal: Front Immunol

PubMed ID: 36248898

Doi: 10.3389/fimmu.2022.1015586

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Spike mutation resilient scFv76 antibody counteracts SARS-CoV-2 lung damage upon aerosol delivery

Authors: Ferdinando M Milazzo, Antonio Chaves-Sanjuan, Olga Minenkova, Daniela Santapaola, Anna M Anastasi, Gianfranco Battistuzzi, Caterina Chiapparino, Antonio Rosi, Emilio Merlo Pich, Claudio Albertoni, Emanuele Marra, Laura Luberto, Cécile Viollet, Luigi G Spagnoli, Anna Riccio, Antonio Rossi, M Gabriella Santoro, Federico Ballabio, Cristina Paissoni, Carlo Camilloni, Martino Bolognesi, Rita De Santis

Journal: Mol Ther

PubMed ID: 36114671

Doi: 10.1016/j.ymthe.2022.09.010

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Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism

Authors: Xiyue Jin, Xue Sun, Yan Chai, Yu Bai, Ying Li, Tianjiao Hao, Jianxun Qi, Hao Song, Catherine C L Wong, George F Gao

Journal: Sci China Life Sci

PubMed ID: 36184694

Doi: 10.1007/s11427-022-2168-8

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Oral or intranasal immunization with recombinant Lactobacillus plantarum displaying head domain of Swine Influenza A virus hemagglutinin protects mice from H1N1 virus

Authors: Yufei Zhang, Li Yang, Jiali Zhang, Kun Huang, Xiaomei Sun, Ying Yang, Ting Wang, Qiang Zhang, Zhong Zou, Meilin Jin

Journal: Microb Cell Fact

PubMed ID: 36085207

Doi: 10.1186/s12934-022-01911-4

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Comparative transcriptome analysis of longissimus dorsi tissues with different intramuscular fat contents from Guangling donkeys

Authors: Wufeng Li, Lixia Qiu, Jiawei Guan, Yutong Sun, Jingwei Zhao, Min Du

Journal: BMC Genomics

PubMed ID: 36085018

Doi: 10.1186/s12864-022-08857-2

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Computer vision enabled funnel adapted sensing tube (FAST) for power-free and pipette-free nucleic acid detection

Authors: Mengdi Bao, Shuhuan Zhang, Chad Ten Pas, Stephen J Dollery, Ruth V Bushnell, F N U Yuqing, Rui Liu, Guoyu Lu, Gregory J Tobin, Ke Du

Journal: Lab Chip

PubMed ID: 36111877

Doi: 10.1039/d2lc00586g

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Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE

Authors: Brendan Miller, Su-Jeong Kim, Hemal H Mehta, Kevin Cao, Hiroshi Kumagai, Neehar Thumaty, Naphada Leelaprachakul, Henry Jiao, Joan Vaughan, Jolene Diedrich, Alan Saghatelian, Thalida E Arpawong, Eileen M Crimmins, Nilüfer Ertekin-Taner, Meral A Tubi, Evan T Hare, Meredith N Braskie, Léa Décarie-Spain, Scott E Kanoski, Francine Grodstein, David A Bennett, Lu Zhao, Arthur W Toga, Junxiang Wan, Kelvin Yen, Pinchas Cohen

Journal: Mol Psychiatry

PubMed ID: 36127429

Doi: 10.1038/s41380-022-01769-3

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Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover

Authors: Sihan Li, Ken Ikeuchi, Misaki Kato, Robert Buschauer, Takato Sugiyama, Shungo Adachi, Hideo Kusano, Tohru Natsume, Otto Berninghausen, Yoshitaka Matsuo, Thomas Becker, Roland Beckmann, Toshifumi Inada

Journal: Mol Cell

PubMed ID: 36113412

Doi: 10.1016/j.molcel.2022.08.018

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mRNA Vaccine Designing Using Chikungunya Virus E Glycoprotein through Immunoinformatics-Guided Approaches

Authors: Samavia Jaan, Aqal Zaman, Sarfraz Ahmed, Mohibullah Shah, Suvash Chandra Ojha

Journal: Vaccines (Basel)

PubMed ID: 36146554

Doi: 10.3390/vaccines10091476

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Peptide-Based HDL as an Effective Delivery System for Lipophilic Drugs to Restrain Atherosclerosis Development

Authors: Junwei Gao, Ziyun Li, Jing Li, Ping Song, Jinsheng Yang, Wei Xiao, Ning Li, Ruodan Xu

Journal: Int J Nanomedicine

PubMed ID: 36097444

Doi: 10.2147/IJN.S374736

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Small secreted peptides encoded on the wheat ( L) genome and their potential roles in stress responses

Authors: Dongdong Tian, Qi Xie, Zhichao Deng, Jin Xue, Wei Li, Zenglin Zhang, Yifei Dai, Bo Zheng, Tiegang Lu, Ive De Smet, Yongfeng Guo

Journal: Front Plant Sci

PubMed ID: 36212358

Doi: 10.3389/fpls.2022.1000297

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Engineered CRISPR prime editors with compact, untethered reverse transcriptases

Authors: Julian Grünewald, Bret R Miller, Regan N Szalay, Peter K Cabeceiras, Christopher J Woodilla, Eliza Jane B Holtz, Karl Petri, J Keith Joung

Journal: Nat Biotechnol

PubMed ID: 36163548

Doi: 10.1038/s41587-022-01473-1

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Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes

Authors: Marcello Scala, Masashi Nishikawa, Hidenori Ito, Hidenori Tabata, Tayyaba Khan, Andrea Accogli, Laura Davids, Anna Ruiz, Pietro Chiurazzi, Gabriella Cericola, Björn Schulte, Kristin G Monaghan, Amber Begtrup, Annalaura Torella, Michele Pinelli, Anne Sophie Denommé-Pichon, Antonio Vitobello, Caroline Racine, Maria Margherita Mancardi, Courtney Kiss, Andrea Guerin, Wendy Wu, Elisabeth Gabau Vila, Bryan C Mak, Julian A Martinez-Agosto, Michael B Gorin, Bugrahan Duz, Yavuz Bayram, Claudia M B Carvalho, Jaime E Vengoechea, David Chitayat, Tiong Yang Tan, Bert Callewaert, Bernd Kruse, Lynne M Bird, Laurence Faivre, Marcella Zollino, Saskia Biskup, Pasquale Striano, Vincenzo Nigro, Mariasavina Severino, Valeria Capra, Gregory Costain, Koh Ichi Nagata

Journal: Brain

PubMed ID: 35851598

Doi: 10.1093/brain/awac106

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Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma

Authors: Xiaoyu Liu, Jingying Zhou, Haoran Wu, Shufen Chen, Lingyun Zhang, Wenshu Tang, Liang Duan, Ying Wang, Eleanor McCabe, Mengying Hu, Zhuo Yu, Hanzhuang Liu, Chung Hang Jonathan Choi, Joseph Jao-Yiu Sung, Leaf Huang, Rihe Liu, Alfred Sze-Lok Cheng

Journal: Mol Ther

PubMed ID: 36146933

Doi: 10.1016/j.ymthe.2022.09.012

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Delivery of ceramide phosphoethanolamine lipids to the cleavage furrow through the endocytic pathway is essential for male meiotic cytokinesis

Authors: Govind Kunduri, Si-Hung Le, Valentina Baena, Nagampalli Vijaykrishna, Adam Harned, Kunio Nagashima, Daniel Blankenberg, Izumi Yoshihiro, Kedar Narayan, Takeshi Bamba, Usha Acharya, Jairaj K Acharya

Journal: PLoS Biol

PubMed ID: 36170207

Doi: 10.1371/journal.pbio.3001599

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Molecular fate-mapping of serum antibodies reveals the effects of antigenic imprinting on repeated immunization

Authors: Ariën Schiepers, Marije F L van 't Wout, Allison J Greaney, Trinity Zang, Hiromi Muramatsu, Paulo J C Lin, Ying K Tam, Luka Mesin, Tyler N Starr, Paul D Bieniasz, Norbert Pardi, Jesse D Bloom, Gabriel D Victora

Journal: biorxiv

PubMed ID: 36093344

Doi: 10.1101/2022.08.29.505743

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Frequency dependent growth of bacteria in living materials

Authors: Daniel D Lewis, Ting Gong, Yuanwei Xu, Cheemeng Tan

Journal: Front Bioeng Biotechnol

PubMed ID: 36159663

Doi: 10.3389/fbioe.2022.948483

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Exploring the Binding Affinity and Mechanism between ACE2 and the Trimers of Delta and Omicron Spike Proteins by Molecular Dynamics Simulation and Bioassay

Authors: Liping Zhou, Tingting Liu, Mengxia Mo, Yulong Shi, Leyun Wu, Yishui Li, Qiuping Qin, Weiliang Zhu, Chengkun Wu, Likun Gong, Zhijian Xu

Journal: J Chem Inf Model

PubMed ID: 36053674

Doi: 10.1021/acs.jcim.2c00881

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A Secreted Form of the Hepatitis E Virus ORF2 Protein: Design Strategy, Antigenicity and Immunogenicity

Authors: Zihao Chen, Shaoqi Guo, Guanghui Li, Dong Ying, Guiping Wen, Mujin Fang, Yingbin Wang, Zimin Tang, Zizheng Zheng, Ningshao Xia

Journal: Viruses

PubMed ID: 36298677

Doi: 10.3390/v14102122

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A LILRB1 variant with a decreased ability to phosphorylate SHP-1 leads to autoimmune diseases

Authors: Thivaratana Sinthuwiwat, Supranee Buranapraditkun, Wuttichart Kamolvisit, Siraprapa Tongkobpetch, Wanna Chetruengchai, Chalurmpon Srichomthong, Adjima Assawapitaksakul, Chureerat Phokaew, Patipark Kueanjinda, Tanapat Palaga, Tadech Boonpiyathad, Kanya Suphapeetiporn, Nattiya Hirankarn, Vorasuk Shotelersuk

Journal: Sci Rep

PubMed ID: 36104364

Doi: 10.1038/s41598-022-19334-x

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Structural Basis of Substrate Promiscuity and Catalysis by the Reverse Prenyltransferase -Dimethylallyl-l-tryptophan Synthase from

Authors: Samuel A Eaton, Trey A Ronnebaum, Benjamin W Roose, David W Christianson

Journal: Biochemistry

PubMed ID: 36084241

Doi: 10.1021/acs.biochem.2c00350

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FtlA and FtlB Are Candidates for Inclusion in a Next-Generation Multiantigen Subunit Vaccine for Lyme Disease

Authors: Andrew C Camire, Nathaniel S O'Bier, Dhara T Patel, Nicholas A Cramer, Reinhard K Straubinger, Edward B Breitschwerdt, Rebecca A Funk, Richard T Marconi

Journal: Infect Immun

PubMed ID: 36102656

Doi: 10.1128/iai.00364-22

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Targeting extracellular matrix remodeling sensitizes glioblastoma to ionizing radiation

Authors: Varsha Thakur, Vijay S Thakur, Brittany Aguila, Tatiana I Slepak, Man Wang, Wei Song, Mohini Konai, Shahriar Mobashery, Mayland Chang, Ayush B Rana, Dazhi Wang, Juliano Tiburcio de Freitas, Sakir Humayun Gultekin, Scott M Welford, Michael E Ivan, Barbara Bedogni

Journal: Neurooncol Adv

PubMed ID: 36212741

Doi: 10.1093/noajnl/vdac147

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A miniaturized bionic ocean-battery mimicking the structure of marine microbial ecosystems

Authors: Huawei Zhu, Liru Xu, Guodong Luan, Tao Zhan, Zepeng Kang, Chunli Li, Xuefeng Lu, Xueli Zhang, Zhiguang Zhu, Yanping Zhang, Yin Li

Journal: Nat Commun

PubMed ID: 36153325

Doi: 10.1038/s41467-022-33358-x

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Proton-transporting heliorhodopsins from marine giant viruses

Authors: Shoko Hososhima, Ritsu Mizutori, Rei Abe-Yoshizumi, Andrey Rozenberg, Shunta Shigemura, Alina Pushkarev, Masae Konno, Kota Katayama, Keiichi Inoue, Satoshi P Tsunoda, Oded Béjà, Hideki Kandori

Journal: Elife

PubMed ID: 36065640

Doi: 10.7554/eLife.78416

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Engineering sorghum for higher 4-hydroxybenzoic acid content

Authors: Chien-Yuan Lin, Yang Tian, Kimberly Nelson-Vasilchik, Joel Hague, Ramu Kakumanu, Mi Yeon Lee, Venkataramana R Pidatala, Jessica Trinh, Christopher M De Ben, Jutta Dalton, Trent R Northen, Edward E K Baidoo, Blake A Simmons, John M Gladden, Corinne D Scown, Daniel H Putnam, Albert P Kausch, Henrik V Scheller, Aymerick Eudes

Journal: Metab Eng Commun

PubMed ID: 36188638

Doi: 10.1016/j.mec.2022.e00207

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A soybean sodium/hydrogen exchanger GmNHX6 confers plant alkaline salt tolerance by regulating Na/K homeostasis

Authors: Ting Jin, Jiaxin An, Huadong Xu, Jie Chen, Lang Pan, Ranran Zhao, Ning Wang, Junyi Gai, Yan Li

Journal: Front Plant Sci

PubMed ID: 36204047

Doi: 10.3389/fpls.2022.938635

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Expressing the Pro-Apoptotic Reaper Protein via Insertion into the Structural Open Reading Frame of Sindbis Virus Reduces the Ability to Infect Mosquitoes

Authors: Alexis Carpenter, Scott R Santos, Rollie J Clem

Journal: Viruses

PubMed ID: 36146841

Doi: 10.3390/v14092035

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Characteristics of NtCCD1-3 from tobacco, and protein engineering of the CCD1 to enhance -ionone production in yeast

Authors: Xiaowei Gong, Fan Li, Yupeng Liang, Xiulin Han, Mengliang Wen

Journal: Front Microbiol

PubMed ID: 36212872

Doi: 10.3389/fmicb.2022.1011297

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Transport of acylated anthocyanins by the Arabidopsis ATP-binding cassette transporters AtABCC1, AtABCC2, and AtABCC14

Authors: John V Dean, Morgan Willis, Laith Shaban

Journal: Physiol Plant

PubMed ID: 36121340

Doi: 10.1111/ppl.13780

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Streptococcus mutans glutamate binding protein (GlnH) as antigen target for a mucosal anti-caries vaccine

Authors: Gisela de Souza Pereira, Milene Tavares Batista, Nayara Fernanda Barros Dos Santos, Hélic Moreira Passos, Dalva Adelina da Silva, Ewerton Lucena Ferreira, Luís Carlos de Souza Ferreira, Rita de Cássia Café Ferreira

Journal: Braz J Microbiol

PubMed ID: 36098933

Doi: 10.1007/s42770-022-00823-0

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Farnesyl pyrophosphate compartmentalization in the green microalga Chlamydomonas reinhardtii during heterologous (E)-α-bisabolene production

Authors: Julian Wichmann, Annibel Eggert, Liam D H Elbourne, Ian T Paulsen, Kyle J Lauersen, Olaf Kruse

Journal: Microb Cell Fact

PubMed ID: 36104783

Doi: 10.1186/s12934-022-01910-5

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The positive regulatory loop of TCF4N/p65 promotes glioblastoma tumourigenesis and chemosensitivity

Authors: Yaling Hu, Bo Zhang, Peihua Lu, Jingying Wang, Cheng Chen, Ying Yin, Quan Wan, Jingjing Wang, Jiantong Jiao, Xiangming Fang, Zhening Pu, Lingli Gong, Li Ji, Lingpeng Zhu, Rui Zhang, Jia Zhang, Xusheng Yang, Qing Wang, Zhaohui Huang, Jian Zou

Journal: Clin Transl Med

PubMed ID: 36116131

Doi: 10.1002/ctm2.1042

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Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-β receptors

Authors: Trinh-Le-Vi Kieu, Léa Pierre, Valentin Derangère, Sabrina Perrey, Caroline Truntzer, Antoine Jalil, Sébastien Causse, Emma Groetz, Adélie Dumont, Laura Guyard, Laurent Arnould, Jean-Paul Pais de Barros, Lionel Apetoh, Cédric Rébé, Emeric Limagne, Tony Jourdan, Laurent Demizieux, David Masson, Charles Thomas, François Ghiringhelli, Mickaël Rialland

Journal: Cell Death Dis

PubMed ID: 36056008

Doi: 10.1038/s41419-022-05209-6

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A sample-to-answer, quantitative real-time PCR system with low-cost, gravity-driven microfluidic cartridge for rapid detection of SARS-CoV-2, influenza A/B, and human papillomavirus 16/18

Authors: Yunfeng Zai, Chao Min, Zunliang Wang, Yongjun Ding, Huan Zhao, Enben Su, Nongyue He

Journal: Lab Chip

PubMed ID: 35972195

Doi: 10.1039/d2lc00434h

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An Unexpected Encounter: Respiratory Syncytial Virus Nonstructural Protein 1 Interacts with Mediator Subunit MED25

Authors: Tessa Van Royen, Koen Sedeyn, George D Moschonas, Wendy Toussaint, Marnik Vuylsteke, Delphi Van Haver, Francis Impens, Sven Eyckerman, Irma Lemmens, Jan Tavernier, Bert Schepens, Xavier Saelens

Journal: J Virol

PubMed ID: 36102648

Doi: 10.1128/jvi.01297-22

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Identification of a Potential Inhibitor (MCULE-8777613195-0-12) of New Delhi Metallo-β-Lactamase-1 (NDM-1) Using In Silico and In Vitro Approaches

Authors: Ghazala Muteeb, Md Tabish Rehman, Mohamed F AlAjmi, Mohammad Aatif, Mohd Farhan, Sheeba Shafi

Journal: Molecules

PubMed ID: 36144666

Doi: 10.3390/molecules27185930

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Kinetic Model and Numerical Simulation of Microbial Growth, Migration, and Oil Displacement in Reservoir Porous Media

Authors: Chuanjin Yao, Xiangxiang Meng, Xiaohuan Qu, Tianxiang Cheng, Qi'an Da, Kai Zhang, Guanglun Lei

Journal: ACS Omega

PubMed ID: 36120076

Doi: 10.1021/acsomega.2c04120

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Genome-wide in vivo screen of circulating tumor cells identifies as a regulator of metastasis

Authors: Fan Xia, Yuan Ma, Kangfu Chen, Bill Duong, Sharif Ahmed, Randy Atwal, David Philpott, Troy Ketela, Jennifer Pantea, Sichun Lin, Stephane Angers, Shana O Kelley

Journal: Sci Adv

PubMed ID: 36054348

Doi: 10.1126/sciadv.abo7792

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Antimicrobial Peptide Mechanism Studied by Scattering-Guided Molecular Dynamics Simulation

Authors: Robert Allsopp, Anna Pavlova, Tyler Cline, Aria M Salyapongse, Richard E Gillilan, Y Peter Di, Berthony Deslouches, Jeffery B Klauda, James C Gumbart, Stephanie Tristram-Nagle

Journal: J Phys Chem B

PubMed ID: 36067064

Doi: 10.1021/acs.jpcb.2c03193

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Modification of the HLA-A*24:02 Peptide Binding Pocket Enhances Cognate Peptide-Binding Capacity and Antigen-Specific T Cell Activation

Authors: Kenji Murata, Dalam Ly, Hiroshi Saijo, Yukiko Matsunaga, Kenji Sugata, Fumie Ihara, Daisuke Oryoji, Yota Ohashi, Kayoko Saso, Chung-Hsi Wang, Evey Y F Zheng, Brian D Burt, Marcus O Butler, Naoto Hirano

Journal: J Immunol

PubMed ID: 36165170

Doi: 10.4049/jimmunol.2200305

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Comparison of SARS-CoV-2 spike antibody quantitative titer reporting using the World Health Organization International Standard Units by four commercial assays

Authors: Ran Zhuo, Carmen Charlton, Sabrina Plitt, L Alexa Thompson, Sheila Braun, Jacqueline Day, Carla Osiowy, Graham Tipples, Jamil N Kanji

Journal: J Clin Virol

PubMed ID: 36108404

Doi: 10.1016/j.jcv.2022.105292

Truncated Tau caused by intron retention is enriched in Alzheimer's disease cortex and exhibits altered biochemical properties

Authors: Zhen-Kai Ngian, Yow-Yong Tan, Ching-Thong Choo, Wei-Qi Lin, Chao-Yong Leow, Shan-Jie Mah, Mitchell Kim-Peng Lai, Christopher Li-Hsian Chen, Chin-Tong Ong

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36067305

Doi: 10.1073/pnas.2204179119

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Reverse Transcription-Loop-Mediated Isothermal Amplification-CRISPR-Cas13a Technology as a Promising Diagnostic Tool for SARS-CoV-2

Authors: Concha Ortiz-Cartagena, Laura Fernández-García, Lucia Blasco, Olga Pacios, Inés Bleriot, María López, Rafael Cantón, María Tomás

Journal: Microbiol Spectr

PubMed ID: 36169448

Doi: 10.1128/spectrum.02398-22

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Host adaptation of codon usage in SARS-CoV-2 from mammals indicates potential natural selection and viral fitness

Authors: Yanan Fu, Yanping Huang, Jingjing Rao, Feng Zeng, Ruiping Yang, Huabing Tan, Zhixin Liu, Weixing Du, Long Liu

Journal: Arch Virol

PubMed ID: 36166106

Doi: 10.1007/s00705-022-05612-6

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Context-based sensing of orthosomycin antibiotics by the translating ribosome

Authors: Kyle Mangano, James Marks, Dorota Klepacki, Chayan Kumar Saha, Gemma C Atkinson, Nora Vázquez-Laslop, Alexander S Mankin

Journal: Nat Chem Biol

PubMed ID: 36138139

Doi: 10.1038/s41589-022-01138-9

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