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Automated model-predictive design of synthetic promoters to control transcriptional profiles in bacteria

Authors: Travis L LaFleur, Ayaan Hossain, Howard M Salis

Journal: Nat Commun

PubMed ID: 36056029

Doi: 10.1038/s41467-022-32829-5

Products & Services: Custom DNA/RNA Oligos

Effect of Foot-and-Mouth Disease Virus 2B Viroporin on Expression and Extraction of Mammalian Cell Culture Produced Foot-and-Mouth Disease Virus-like Particles

Authors: Victoria Primavera, Janine Simmons, Benjamin A Clark, John G Neilan, Michael Puckette

Journal: Vaccines (Basel)

PubMed ID: 36146583

Doi: 10.3390/vaccines10091506

Products & Services: Custom Vector Construction

Mechanistic understanding of human SLFN11

Authors: Felix J Metzner, Simon J Wenzl, Michael Kugler, Stefan Krebs, Karl-Peter Hopfner, Katja Lammens

Journal: Nat Commun

PubMed ID: 36115853

Doi: 10.1038/s41467-022-33123-0

Products & Services: Proteins, Expression, Isolation and Analysis

Viruses inhibit TIR gcADPR signaling to overcome bacterial defense

Authors: Azita Leavitt, Erez Yirmiya, Gil Amitai, Allen Lu, Jeremy Garb, Ehud Herbst, Benjamin R Morehouse, Samuel J Hobbs, Sadie P Antine, Zhen-Yu J Sun, Philip J Kranzusch, Rotem Sorek

Journal: Nature

PubMed ID: 36174646

Doi: 10.1038/s41586-022-05375-9

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Glycosyltransferase engineering and multi-glycosylation routes development facilitating synthesis of high-intensity sweetener mogrosides

Authors: Jiao Li, Shicheng Mu, Jiangang Yang, Cui Liu, Yanfei Zhang, Peng Chen, Yan Zeng, Yueming Zhu, Yuanxia Sun

Journal: iScience

PubMed ID: 36248741

Doi: 10.1016/j.isci.2022.105222

Products & Services: Mutant Libraries

Evaluating Primary Endpoints for COVID-19 Therapeutic Trials to Assess Recovery

Authors: David J Douin, Lianne Siegel, Greg Grandits, Andrew Phillips, Neil R Aggarwal, Jason Baker, Samuel M Brown, Christina C Chang, Anna L Goodman, Birgit Grund, Elizabeth S Higgs, Catherine L Hough, Daniel D Murray, Roger Paredes, Mahesh Parmar, Sarah Pett, Mark N Polizzotto, Uriel Sandkovsky, Wesley H Self, Barnaby E Young, Abdel G Babiker, Victoria J Davey, Virginia Kan, Annetine C Gelijns, Gail Matthews, B Taylor Thompson, H Clifford Lane, James D Neaton, Jens D Lundgren, Adit A Ginde

Journal: Am J Respir Crit Care Med

PubMed ID: 35580040

Doi: 10.1164/rccm.202112-2836OC

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Impact of hypertension on long-term humoral and cellular response to SARS-CoV-2 infection

Authors: Chang Chu, Anne Schönbrunn, Kristin Klemm, Volker von Baehr, Bernhard K Krämer, Saban Elitok, Berthold Hocher

Journal: Front Immunol

PubMed ID: 36119050

Doi: 10.3389/fimmu.2022.915001

DNA Prime and Recombinant Protein Boost Vaccination Confers Chickens with Enhanced Protection against Chicken Infectious Anemia Virus

Authors: Ling Liu, Mingrong Yin, Yang Li, Hong Su, Lichun Fang, Xiaolong Sun, Shuang Chang, Peng Zhao, Yixin Wang

Journal: Viruses

PubMed ID: 36298670

Doi: 10.3390/v14102115

Products & Services: Proteins, Expression, Isolation and Analysis

The first molecular identification and phylogenetic analysis of tick-borne pathogens in captive wild animals from Lohi Bher zoo, Pakistan

Authors: Muhammad Uzair Mukhtar, Naveed Iqbal, Jifei Yang, Zeeshan Nawaz, Tan Li Peng

Journal: Parasitol Res

PubMed ID: 36114837

Doi: 10.1007/s00436-022-07666-6

Products & Services: DNA Sequencing

Ras GTPase-activating proteins control neuronal circuit development in barrel cortex layer 4

Authors: Madhura S Rao, Hiromi Mizuno, Takuji Iwasato, Hidenobu Mizuno

Journal: Front Neurosci

PubMed ID: 36188467

Doi: 10.3389/fnins.2022.901774

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Engineered flavivirus vaccines control induction of crossreactive infection-enhancing and -neutralizing antibodies

Authors: Atsushi Yamanaka, Pimploy Rattanaamnuaychai, Mami Matsuda, Ryosuke Suzuki, Yoshiharu Matsuura, Masashi Tatsumi, Eiji Konishi

Journal: Vaccine

PubMed ID: 36109279

Doi: 10.1016/j.vaccine.2022.09.012

Products & Services: Mutagenesis Services

An alternative angiosperm DGAT1 topology and potential motifs in the N-terminus

Authors: Somrutai Winichayakul, Amy Curran, Roger Moraga, Ruth Cookson, Hong Xue, Tracey Crowther, Marissa Roldan, Greg Bryan, Nick Roberts

Journal: Front Plant Sci

PubMed ID: 36186081

Doi: 10.3389/fpls.2022.951389

Products & Services: PCR Cloning and Subcloning

Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens

Authors: John C Kraft, Minh N Pham, Laila Shehata, Mitch Brinkkemper, Seyhan Boyoglu-Barnum, Kaitlin R Sprouse, Alexandra C Walls, Suna Cheng, Mike Murphy, Deleah Pettie, Maggie Ahlrichs, Claire Sydeman, Max Johnson, Alyssa Blackstone, Daniel Ellis, Rashmi Ravichandran, Brooke Fiala, Samuel Wrenn, Marcos Miranda, Kwinten Sliepen, Philip J M Brouwer, Aleksandar Antanasijevic, David Veesler, Andrew B Ward, Masaru Kanekiyo, Marion Pepper, Rogier W Sanders, Neil P King

Journal: Cell Rep Med

PubMed ID: 36206752

Doi: 10.1016/j.xcrm.2022.100780

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Color-Switchable Nanosilicon Fluorescent Probes

Authors: Huai Chen, Jiang Xu, Yaping Wang, Da Wang, Raquel Ferrer-Espada, Yutong Wang, Jingjian Zhou, Adrián Pedrazo-Tardajos, Mei Yang, Jia-Heng Tan, Xiaoyu Yang, Lei Zhang, Ilya Sychugov, Shoudeng Chen, Sara Bals, Johan Paulsson, Zhenyu Yang

Journal: ACS Nano

PubMed ID: 36107985

Doi: 10.1021/acsnano.2c07443

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The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling

Authors: Manoshi Gayen, Marc R Benoit, Qingyuan Fan, Jacob Hudobenko, Riqiang Yan

Journal: J Biol Chem

PubMed ID: 36162508

Doi: 10.1016/j.jbc.2022.102532

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An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension

Authors: Elisabeth Fuchs, Imke Rudnik-Jansen, Anders Dinesen, Denis Selnihhin, Ole Aalund Mandrup, Kader Thiam, Jørgen Kjems, Finn Skou Pedersen, Kenneth A Howard

Journal: Acta Biomater

PubMed ID: 36162760

Doi: 10.1016/j.actbio.2022.09.048

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Enhanced and Potency of a T Cell Epitope in the Ebola Virus Glycoprotein Following Amino Acid Replacement at HLA-A*02:01 Binding Positions

Authors: Sylvie Chabot, Yusra Gimie, Karam Obeid, Jaekwan Kim, Clement A Meseda, Krishnamurthy Konduru, Gerardo Kaplan, Li Sheng Fowler, Jerry P Weir, Keith Peden, Marian E Major

Journal: J Virol

PubMed ID: 36069549

Doi: 10.1128/jvi.01166-21

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miR-3651 Participates in the Growth Cycle of Hepatocellular Carcinoma Cells and Promotes the Malignant Metastasis via the PI3K/AKT/mTOR Signalling Pathway

Authors: Yawei Liu, Litian Hu, Qinqiang Liu, Jing Ye, Jianping Zhang

Journal: J Oncol

PubMed ID: 36245984

Doi: 10.1155/2022/5744999

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Gene Promotes Muscle Growth and Development in Meat Ducks

Authors: Tingting Zhou, Yijing Wu, Yulin Bi, Hao Bai, Yong Jiang, Guohong Chen, Guobin Chang, Zhixiu Wang

Journal: Genes (Basel)

PubMed ID: 36140742

Doi: 10.3390/genes13091574

Products & Services: DNA Sequencing

Chaperonin CCT5 binding with porcine parvovirus NS1 promotes the interaction of NS1 and COPƐ to facilitate viral replication

Authors: Qian Du, Xuezhi Zhang, Ning Xu, Mengyu Ma, Bicheng Miao, Yong Huang, Dewen Tong

Journal: Vet Microbiol

PubMed ID: 36126504

Doi: 10.1016/j.vetmic.2022.109574

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Near Infrared Emitting Semiconductor Polymer Dots for Bioimaging and Sensing

Authors: Connor Riahin, Kushani Mendis, Brandon Busick, Marcin Ptaszek, Mengran Yang, Gary Stacey, Amar Parvate, James E Evans, Jeremiah Traeger, Dehong Hu, Galya Orr, Zeev Rosenzweig

Journal: Sensors (Basel)

PubMed ID: 36236328

Doi: 10.3390/s22197218

Products & Services: Proteins, Expression, Isolation and Analysis

High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development

Authors: Shalev Gihaz, Peter Gareiss, Jae-Yeon Choi, Isaline Renard, Anasuya Chattopadhyay Pal, Yulia Surovsteva, Joy E Chiu, Jose Thekkiniath, Mark Plummer, William Hungerford, Micaela L Montgomery, Alanah Hosford, Emily M Adams, Jorge D Lightfoot, David Fox, Kayode K Ojo, Bart L Staker, Kevin Fuller, Choukri Ben Mamoun

Journal: Structure

PubMed ID: 36167065

Doi: 10.1016/j.str.2022.09.001

Products & Services: Plasmid DNA Preparation

CycC1;1 negatively modulates ABA signaling by interacting with and inhibiting ABI5 during seed germination

Authors: Jia-Xing Guo, Ru-Feng Song, Kai-Kai Lu, Yu Zhang, Hui-Hui Chen, Jia-Xin Zuo, Ting-Ting Li, Xue-Feng Li, Wen-Cheng Liu

Journal: Plant Physiol

PubMed ID: 36173345

Doi: 10.1093/plphys/kiac456

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Identification of a broad lipid repertoire associated to the endothelial cell protein C receptor (EPCR)

Authors: Elena Erausquin, María Morán-Garrido, Jorge Sáiz, Coral Barbas, Gilda Dichiara-Rodríguez, Alejandro Urdiciain, Jacinto López-Sagaseta

Journal: Sci Rep

PubMed ID: 36068249

Doi: 10.1038/s41598-022-18844-y

Products & Services: Mammalian Expression

Novel method for detecting complement C3 deposition on Staphylococcus aureus

Authors: Toska Wonfor, Shuxian Li, Rhys W Dunphy, Alex Macpherson, Jean van den Elsen, Maisem Laabei

Journal: Sci Rep

PubMed ID: 36130996

Doi: 10.1038/s41598-022-20098-7

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Phospholipase C-related catalytically inactive protein enhances cisplatin-induced apoptotic cell death

Authors: Satoshi Asano, Yuka Maetani, Yukio Ago, Takashi Kanematsu

Journal: Eur J Pharmacol

PubMed ID: 36108738

Doi: 10.1016/j.ejphar.2022.175273

Products & Services: Gene Synthesis

TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy

Authors: Chengyang Li, Patrick Duckney, Tong Zhang, Yanshu Fu, Xin Li, Johan Kroon, Geert De Jaeger, Yunjiang Cheng, Patrick J Hussey, Pengwei Wang

Journal: Nat Commun

PubMed ID: 36163196

Doi: 10.1038/s41467-022-33402-w

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Tumor-Intrinsic PD-L1 Exerts an Oncogenic Function through the Activation of the Wnt/β-Catenin Pathway in Human Non-Small Cell Lung Cancer

Authors: Yunxia Ma, Rumyana Marinkova, Miljana Nenkov, Lai Jin, Otmar Huber, Jürgen Sonnemann, Natália Peca, Nikolaus Gaßler, Yuan Chen

Journal: Int J Mol Sci

PubMed ID: 36232331

Doi: 10.3390/ijms231911031

Products & Services: Mammalian Expression

Nuclear Factor Kappa B Promotes Ferritin Heavy Chain Expression in in Response to Nucleopolyhedrovirus Infection

Authors: Linbao Zhu, Yingxue Liu, Ancheng Wang, Xiya Chen, Handan Zhu, Zhihao Huang, Huihua Cao, Shihuo Liu, Jiaping Xu

Journal: Int J Mol Sci

PubMed ID: 36142290

Doi: 10.3390/ijms231810380

Products & Services: Recombinant Antibody Expression

Removal of redox-sensitive Rubisco Activase does not alter Rubisco regulation in soybean

Authors: Christopher M Harvey, Amanda P Cavanagh, Sang Yeol Kim, David A Wright, Ron G Edquilang, Kayla S Shreeves, Juan Alejandro Perdomo, Martin H Spalding, Donald R Ort, Carl J Bernacchi, Steven C Huber

Journal: Photosynth Res

PubMed ID: 36163583

Doi: 10.1007/s11120-022-00962-3

Products & Services: Polyclonal Antibody Services

A review post-vaccination SARS-CoV-2 serological test: Method and antibody titer response

Authors: Melania Janisha Devi, Shabarni Gaffar, Yeni Wahyuni Hartati

Journal: Anal Biochem

PubMed ID: 36122603

Doi: 10.1016/j.ab.2022.114902

Products & Services: Recombinant Proteins

Targeting of palpable B16-F10 melanoma tumors with polyclonal antibodies on white blood cells

Authors: Girja S Shukla, Stephanie C Pero, Linda Mei, Yu-Jing Sun, David N Krag

Journal: J Immunol Methods

PubMed ID: 36174735

Doi: 10.1016/j.jim.2022.113362

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Plant transcripts with long or structured uORFs in NDL2 5' UTR can escape NMD in a reinitiation independent manner

Authors: Miryam A Cymerman, Helen Saul, Ronit Farhi, Karina Vexler, Dror Gottlieb, Irina Berezin, Orit Shaul

Journal: J Exp Bot

PubMed ID: 36169317

Doi: 10.1093/jxb/erac385

Products & Services: Proteins, Expression, Isolation and Analysis

Fluorescence Spectroscopy of Low-Level Endogenous β-Adrenergic Receptor Expression at the Plasma Membrane of Differentiating Human iPSC-Derived Cardiomyocytes

Authors: Philipp Gmach, Marc Bathe-Peters, Narasimha Telugu, Duncan C Miller, Paolo Annibale

Journal: Int J Mol Sci

PubMed ID: 36142320

Doi: 10.3390/ijms231810405

Products & Services: Plasmid DNA Preparation

Herpes simplex virus lymphadenitis is associated with tumor reduction in a patient with chronic lymphocytic leukemia

Authors: Andres Chang, Anton M Sholukh, Andreas Wieland, David L Jaye, Mary Carrington, Meei-Li Huang, Hong Xie, Keith R Jerome, Pavitra Roychoudhury, Alexander L Greninger, Jean L Koff, Jonathon B Cohen, David M Koelle, Lawrence Corey, Christopher R Flowers, Rafi Ahmed

Journal: J Clin Invest

PubMed ID: 35862190

Doi: 10.1172/JCI161109

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Microarray-guided evaluation of the frequency, B-cell origins, and selectivity of human glycan-binding antibodies reveals new insights and novel antibodies

Authors: J Sebastian Temme, Jennifer A Crainic, Laura M Walker, Weizhun Yang, Zibin Tan, Xuefei Huang, Jeffrey C Gildersleeve

Journal: J Biol Chem

PubMed ID: 36087840

Doi: 10.1016/j.jbc.2022.102468

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Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor

Authors: Xiyuan Zhang, Hannah E Lou, Vishaka Gopalan, Zhihui Liu, Hilda M Jafarah, Haiyan Lei, Paige Jones, Carly M Sayers, Marielle E Yohe, Prashant Chittiboina, Brigitte C Widemann, Carol J Thiele, Michael C Kelly, Sridhar Hannenhalli, Jack F Shern

Journal: Cell Rep

PubMed ID: 36130486

Doi: 10.1016/j.celrep.2022.111363

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Alamandine alleviated heart failure and fibrosis in myocardial infarction mice

Authors: Kun Zhao, Tianhua Xu, Yukang Mao, Xiaoguang Wu, Dongxu Hua, Yanhui Sheng, Peng Li

Journal: Biol Direct

PubMed ID: 36167556

Doi: 10.1186/s13062-022-00338-6

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Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors

Authors: Jordan R Willis, Zachary T Berndsen, Krystal M Ma, Jon M Steichen, Torben Schiffner, Elise Landais, Alessia Liguori, Oleksandr Kalyuzhniy, Joel D Allen, Sabyasachi Baboo, Oluwarotimi Omorodion, Jolene K Diedrich, Xiaozhen Hu, Erik Georgeson, Nicole Phelps, Saman Eskandarzadeh, Bettina Groschel, Michael Kubitz, Yumiko Adachi, Tina-Marie Mullin, Nushin B Alavi, Samantha Falcone, Sunny Himansu, Andrea Carfi, Ian A Wilson, John R Yates, James C Paulson, Max Crispin, Andrew B Ward, William R Schief

Journal: Immunity

PubMed ID: 36179689

Doi: 10.1016/j.immuni.2022.09.001

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Intranasal Immunization with Liposome-Displayed Receptor-Binding Domain Induces Mucosal Immunity and Protection against SARS-CoV-2

Authors: Wei-Chiao Huang, Kevin Chiem, Luis Martinez-Sobrido, Jonathan F Lovell

Journal: Pathogens

PubMed ID: 36145467

Doi: 10.3390/pathogens11091035

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Inactivated COVID-19 vaccines: durability of Covaxin/BBV152 induced immunity against variants of concern

Authors: Nathella Pavan Kumar, V V Banurekha, C P Girish Kumar, Arul Nancy, Chandrasekaran Padmapriyadarsini, Sakila Shankar, Luke Elizabeth Hanna, Manoj Murhekar, K R Uma Devi, Subash Babu

Journal: J Travel Med

PubMed ID: 35900009

Doi: 10.1093/jtm/taac088

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High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity

Authors: Rodrigo Vazquez-Lombardi, Johanna S Jung, Fabrice S Schlatter, Anna Mei, Natalia Rodrigues Mantuano, Florian Bieberich, Kai-Lin Hong, Jakub Kucharczyk, Edo Kapetanovic, Erik Aznauryan, Cédric R Weber, Alfred Zippelius, Heinz Läubli, Sai T Reddy

Journal: Immunity

PubMed ID: 36174557

Doi: 10.1016/j.immuni.2022.09.004

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mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts

Authors: Denzil Furtado, Christina Cortez-Jugo, Ya Hui Hung, Ashley I Bush, Frank Caruso

Journal: Mol Pharm

PubMed ID: 36125338

Doi: 10.1021/acs.molpharmaceut.2c00463

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A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity

Authors: Lian-Sheng Cheng, Yong-Feng Cheng, Wen-Ting Liu, Aolin Shen, Dayan Zhang, Tingjuan Xu, Wu Yin, Min Cheng, Xiaopeng Ma, Fengrong Wang, Qun Zhao, Xiaoli Zeng, Yan Zhang, Guodong Shen

Journal: J Transl Med

PubMed ID: 36076251

Doi: 10.1186/s12967-022-03619-w

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H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity

Authors: Huasong Ai , Maoshen Sun , Aijun Liu , Zixian Sun , Tingting Liu , Lin Cao , Lujun Liang , Qian Qu , Zichen Li , Zhiheng Deng , Zebin Tong , Guochao Chu , Xiaolin Tian , Haiteng Deng , Suwen Zhao , Jia-Bin Li , Zhiyong Lou , Lei Liu

Journal: Nat Chem Biol

PubMed ID: 35739357

Doi: 10.1038/s41589-022-01067-7

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The SOS response-associated peptidase (SRAP) domain of YedK catalyzes ring opening of abasic sites and reversal of its DNA–protein cross-link

Authors: Katherine A Paulin , David Cortez , Brandt F Eichman

Journal: J Biol Chem

PubMed ID: 35934051

Doi: 10.1016/j.jbc.2022.102307

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Guide RNA engineering enables efficient CRISPR editing with a miniature Syntrophomonas palmitatica Cas12f1 nuclease

Authors: Yujue Wang , Yannan Wang ， Deng Pan , Haopeng Yu , Yifei Zhang , Weizhong Chen , Fan Li , Zhaowei Wu , Quanjiang Ji

Journal: Cell Rep

PubMed ID: 36170834

Doi: doi.org/10.1016/j.celrep.2022.111418

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Nilaparvata lugens salivary protein NlG14 triggers defense response in plants

Authors: Haoli Gao , Jianzheng Zou , Xumin Lin , Huihui Zhang , Na Yu , Zewen Liu

Journal: J Exp Bot

PubMed ID: 36056768

Doi: 10.1093/jxb/erac354

Products & Services: Proteins, Expression, Isolation and Analysis

Autophagic flux restoration of senescent T cells improves antitumor activity of TCR-engineered T cells

Authors: Chaoting Zhang, Yizhe Sun, Shance Li, Luyan Shen, Xia Teng, Yefei Xiao, Ping Zhou, Zheming Lu

Journal: Clin Transl Immunology

PubMed ID: 36188121

Doi: 10.1002/cti2.1419

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Proposal to Consider Chemical/Physical Microenvironment as a New Therapeutic Off-Target Approach

Authors: Alessandro Giuliani, Stefano Fais

Journal: Pharmaceutics

PubMed ID: 36297518

Doi: 10.3390/pharmaceutics14102084

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Development of a GalNAc-Tyrosine-Specific Monoclonal Antibody and Detection of Tyrosine -GalNAcylation in Numerous Human Tissues and Cell Lines

Authors: Li Xia, Tiffany R Bellomo, Ruslan Gibadullin, Molly D Congdon, Elijah F Edmondson, Mi Li, Alexander Wlodawer, Crystal Li, J Sebastian Temme, Pavan Patel, Donna Butcher, Jeffrey C Gildersleeve

Journal: J Am Chem Soc

PubMed ID: 36054098

Doi: 10.1021/jacs.2c04477

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Febuxostat Alleviates Allergic Rhinitis by Inhibiting Inflammation and Monocyte Adhesion in Human Nasal Epithelial Cells via Regulating KLF6

Authors: Yuting Yao, Ran Wei, Hui Jiang

Journal: Evid Based Complement Alternat Med

PubMed ID: 36118091

Doi: 10.1155/2022/9092311

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Mitochondrial derived peptide MOTS-c prevents the development of heart failure under pressure overload conditions in mice

Authors: Peng Zhong, Jianye Peng, Yewen Hu, Jun Zhang, Caijie Shen

Journal: J Cell Mol Med

PubMed ID: 36156853

Doi: 10.1111/jcmm.17551

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Simple and practical sialoglycan encoding system reveals vast diversity in nature and identifies a universal sialoglycan-recognizing probe derived from AB5 toxin B subunits

Authors: Aniruddha Sasmal, Naazneen Khan, Zahra Khedri, Benjamin P Kellman, Saurabh Srivastava, Andrea Verhagen, Hai Yu, Anders Bech Bruntse, Sandra Diaz, Nissi Varki, Travis Beddoe, Adrienne W Paton, James C Paton, Xi Chen, Nathan E Lewis, Ajit Varki

Journal: Glycobiology

PubMed ID: 36048714

Doi: 10.1093/glycob/cwac057

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Recombinant COVID-19 vaccine based on recombinant RBD/Nucleoprotein and saponin adjuvant induces long-lasting neutralizing antibodies and cellular immunity

Authors: Amir Ghaemi, Parisa Roshani Asl, Hedieh Zargaran, Delaram Ahmadi, Asim Ali Hashimi, Elahe Abdolalipour, Sahar Bathaeian, Seyed Mohammad Miri

Journal: Front Immunol

PubMed ID: 36159845

Doi: 10.3389/fimmu.2022.974364

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Effects of TAMP family on the tight junction strand network and barrier function in epithelial cells

Authors: Akira C Saito, Chisato Endo, Yugo Fukazawa, Tomohito Higashi, Hideki Chiba

Journal: Ann N Y Acad Sci

PubMed ID: 36069127

Doi: 10.1111/nyas.14889

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Riboflavin salvage by Borrelia burgdorferi supports carbon metabolism and is essential for survival in the tick vector

Authors: Darlene Ramos, Amanda G Lasseter, Crystal L Richards, Benjamin Schwarz, Susmita Ghosh, Berta Victoria, Catharine M Bosio, Frank C Gherardini, Mollie W Jewett

Journal: Mol Microbiol

PubMed ID: 36054485

Doi: 10.1111/mmi.14977

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RUP2 facilitates UVR8 redimerization via two interfaces

Authors: Lixia Wang, Yidong Wang, Hongfei Chang, Hui Ren, Xinquan Wu, Jia Wen, Zeyuan Guan, Ling Ma, Liang Qiu, Junjie Yan, Delin Zhang, Xi Huang, Ping Yin

Journal: Plant Commun

PubMed ID: 36065466

Doi: 10.1016/j.xplc.2022.100428

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De novo sphingolipid biosynthesis necessitates detoxification in cancer cells

Authors: Meghan E Spears, Namgyu Lee, Sunyoung Hwang, Sung Jin Park, Anne E Carlisle, Rui Li, Mihir B Doshi, Aaron M Armando, Jenny Gao, Karl Simin, Lihua Julie Zhu, Paul L Greer, Oswald Quehenberger, Eduardo M Torres, Dohoon Kim

Journal: Cell Rep

PubMed ID: 36170811

Doi: 10.1016/j.celrep.2022.111415

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Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein

Authors: Xiaoxiao Ren, Huijuan Zhu, Keyong Deng, Xiaotong Ning, Lin Li, Dan Liu, Bin Yang, Chenyang Shen, Xianqiang Wang, Naqiong Wu, Shufeng Chen, Dongfeng Gu, Laiyuan Wang

Journal: Arterioscler Thromb Vasc Biol

PubMed ID: 36172865

Doi: 10.1161/ATVBAHA.122.318158

Products & Services: Proteins, Expression, Isolation and Analysis

Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies

Authors: Cathrine Scheepers, Prudence Kgagudi, Nonkululeko Mzindle, Elin S Gray, Thandeka Moyo-Gwete, Bronwen E Lambson, Brent Oosthuysen, Batsirai Mabvakure, Nigel J Garrett, Salim S Abdool Karim, Lynn Morris, Penny L Moore

Journal: PLoS Pathog

PubMed ID: 36054228

Doi: 10.1371/journal.ppat.1010450

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Identification of Aedes aegypti salivary gland proteins interacting with human immune receptor proteins

Authors: Edem Gavor, Yeu Khai Choong, Yonghao Liu, Julien Pompon, Eng Eong Ooi, Yu Keung Mok, Haiyan Liu, R Manjunatha Kini, J Sivaraman

Journal: PLoS Negl Trop Dis

PubMed ID: 36070318

Doi: 10.1371/journal.pntd.0010743

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Anti-Phytophthora Activity of Halofuginone and the Corresponding Mode of Action

Authors: Saisai Zhang, Jialing Cai, Yimeng Xie, Xinyu Zhang, Xilang Yang, Shenyuan Lin, Wensheng Xiang, Ji Zhang

Journal: J Agric Food Chem

PubMed ID: 36126316

Doi: 10.1021/acs.jafc.2c04266

Products & Services: Proteins, Expression, Isolation and Analysis

EuRBG10 involved in indole alkaloids biosynthesis in Eucommia ulmoides induced by drought and salt stresses

Authors: Yanjun Zuo, Bairu Li, Suixia Guan, Jingyu Jia, Xinjie Xu, Zilong Zhang, Zheng Lu, Xin Li, Xinyue Pang

Journal: J Plant Physiol

PubMed ID: 36179396

Doi: 10.1016/j.jplph.2022.153813

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SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins

Authors: Tyler D R Vance, Patrick Yip, Elisabet Jiménez, Sheng Li, Diana Gawol, James Byrnes, Isabel Usón, Ahmed Ziyyat, Jeffrey E Lee

Journal: Commun Biol

PubMed ID: 36115925

Doi: 10.1038/s42003-022-03883-y

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Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia

Authors: Houfang Long, Shengnan Zhang, Shuyi Zeng, Yilun Tong, Jun Liu, Cong Liu, Dan Li

Journal: Cell Rep

PubMed ID: 36130498

Doi: 10.1016/j.celrep.2022.111401

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Protein Stabilization by Alginate Binding and Suppression of Thermal Aggregation

Authors: Roger Chang, Martin Gruebele, Deborah E Leckband

Journal: Biomacromolecules

PubMed ID: 36054903

Doi: 10.1021/acs.biomac.2c00297

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Small Molecule Antibiotics Inhibit Distinct Stages of Bacterial Outer Membrane Protein Assembly

Authors: Janine H Peterson, Matthew Thomas Doyle, Harris D Bernstein

Journal: MBio

PubMed ID: 36165532

Doi: 10.1128/mbio.02286-22

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De Novo design of a humanized antiCD33 antibody-oridonin conjugate for acute myeloid leukemia therapy

Authors: Hui Feng, Yi Liu, Mengyao Zhang, Ruimin Liu, Jincheng Wang, Wenjuan Wang, Pengcheng He, Penghui Zhang, Fan Niu

Journal: Biochem Biophys Res Commun

PubMed ID: 36122452

Doi: 10.1016/j.bbrc.2022.09.032

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Unveiling the Essential Role of Arkadia's Non-RING Elements in the Ubiquitination Process

Authors: Maria Birkou, Georgia N Delegkou, Konstantinos D Marousis, Nefeli Fragkaki, Tamara Toro, Vasso Episkopou, Georgios A Spyroulias

Journal: Int J Mol Sci

PubMed ID: 36142504

Doi: 10.3390/ijms231810585

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Cutaneous kinase activity correlates with treatment outcomes following PI3K delta inhibition in mice with experimental pemphigoid diseases

Authors: Saeedeh Ghorbanalipoor, Shirin Emtenani, Melissa Parker, Mayumi Kamaguchi, Colin Osterloh, Manuela Pigors, Natalie Gross, Stanislav Khil'chenko, Anika Kasprick, Sabrina Patzelt, Diana Wortmann, Ibrahim O Ibrahim, Kentaro Izumi, Stephanie Goletz, Katharina Boch, Kathrin Kalies, Katja Bieber, Paul Smith, Enno Schmidt, Ralf J Ludwig

Journal: Front Immunol

PubMed ID: 36248903

Doi: 10.3389/fimmu.2022.865241

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Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirus

Authors: Scott A Rush, Gurpreet Brar, Ching-Lin Hsieh, Emilie Chautard, Jennifer N Rainho-Tomko, Chris D Slade, Christine A Bricault, Ana Kume, James Kearns, Rachel Groppo, Sophia T Mundle, Linong Zhang, Danilo Casimiro, Tong-Ming Fu, Joshua M DiNapoli, Jason S McLellan

Journal: Cell Rep

PubMed ID: 36130517

Doi: 10.1016/j.celrep.2022.111399

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Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy

Authors: Andrea Raspadori, Valentina Vignali, Anna Murello, Gabriele Giachin, Bruno Samorì, Motomasa Tanaka, Carlos Bustamante, Giampaolo Zuccheri, Giuseppe Legname

Journal: Biology (Basel)

PubMed ID: 36138837

Doi: 10.3390/biology11091358

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Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma

Authors: Akira Nakamizo, Yuichiro Miyamatsu, Haruka Hirose, Toshiyuki Amano, Satoshi Matsuo, Minako Fujiwara, Teppei Shimamura, Koji Yoshimoto

Journal: Sci Rep

PubMed ID: 36175487

Doi: 10.1038/s41598-022-20613-w

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Co-expression and Interaction of Pax6 with Genes and Proteins of Immunological Surveillance in the Brain of Mice

Authors: Shashank Kumar Maurya, Rajnikant Mishra

Journal: Neurotox Res

PubMed ID: 36069979

Doi: 10.1007/s12640-022-00562-y

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The Musashi proteins direct post-transcriptional control of protein expression and alternate exon splicing in vertebrate photoreceptors

Authors: Fatimah Matalkah, Bohye Jeong, Macie Sheridan, Eric Horstick, Visvanathan Ramamurthy, Peter Stoilov

Journal: Commun Biol

PubMed ID: 36153373

Doi: 10.1038/s42003-022-03990-w

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Boosting the Cannabidiol Production in Engineered by Harnessing the Vacuolar Transporter BPT1

Authors: Jie Qiu, Kangxin Hou, Qiang Li, Jialin Chen, Xiwen Li, Hongping Hou, Liqiang Wang, Jia Liu, Qiang Xue, Caixia Wang

Journal: J Agric Food Chem

PubMed ID: 36122349

Doi: 10.1021/acs.jafc.2c05468

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Investigation of the Neutralizing Antibody Response of Healthcare Workers at a Korean University Hospital Six Months After the Introduction of the COVID-19 Vaccine

Authors: Seong-Ho Choi, Ji Young Park, Joung Ha Park, Min-Chul Kim, Oh Joo Kweon, Jin-Won Chung

Journal: Ann Lab Med

PubMed ID: 35470282

Doi: 10.3343/alm.2022.42.5.612

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Immunoglobulin yolk targeting spike 1, receptor binding domain of spike glycoprotein and nucleocapsid of SARS-CoV-2 blocking RBD-ACE2 binding interaction

Authors: Meliana Eka Saputri, Siti Aisyah Rahmalia Effendi, Rifa Nadila, Syauqi Azzam Fajar, Retno Damajanti Soejoedono, Ekowati Handharyani, Okti Nadia Poetri

Journal: Int Immunopharmacol

PubMed ID: 36183680

Doi: 10.1016/j.intimp.2022.109280

Splice-switch oligonucleotide-based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC-driven hepatocellular carcinoma

Authors: Dexter Kai Hao Thng, Tan Boon Toh, Paolo Pigini, Lissa Hooi, Yock Young Dan, Pierce Kah-Hoe Chow, Glenn Kunnath Bonney, Masturah Bte Mohd Abdul Rashid, Ernesto Guccione, Dave Keng Boon Wee, Edward Kai-Hua Chow

Journal: Bioeng Transl Med

PubMed ID: 36684069

Doi: 10.1002/btm2.10363

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Body Weight is Inversely Associated with Anti-SARS-CoV-2 Antibody Levels after BNT162b2 mRNA Vaccination in Young and Middle Aged Adults

Authors: Su Youn Nam, Seong Woo Jeon, Deuk Kju Jung, Sung-Jae Heo

Journal: Infect Chemother

PubMed ID: 36196609

Doi: 10.3947/ic.2022.0089

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Comprehensive analysis of mitogenome of native Henan pig breeds with 58 worldwide pig breeds

Authors: Menghao Zhang, Chen Zhang, Panyang Hu, Lidan Shi, Mingming Ju, Ben Zhang, Xinjian Li, Xuelei Han, Kejun Wang, Xiuling Li, Ruimin Qiao

Journal: Anim Genet

PubMed ID: 36071602

Doi: 10.1111/age.13261

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PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design

Authors: Jeetendra Kumar Nag, Hodaya Malka, Shoshana Sedley, Priyanga Appasamy, Tatyana Rudina, Tgst Levi, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, Rachel Bar-Shavit

Journal: Mol Cancer Ther

PubMed ID: 36066448

Doi: 10.1158/1535-7163.MCT-21-0946

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Role of lipopolysaccharide in antimicrobial and cell penetrating peptide membrane interactions probed by deuterium NMR of whole cells

Authors: Sarika Kumari, Michael R Morrow, Valerie Booth

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 36155053

Doi: 10.1016/j.bbamem.2022.184053

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OsAMT1;1 and OsAMT1;2 Coordinate Root Morphological and Physiological Responses to Ammonium for Efficient Nitrogen Foraging in Rice

Authors: Xiangyu Wu, Xiaoxiao Xie, Shan Yang, Qianyu Yin, Huairong Cao, Xiaonan Dong, Jing Hui, Zhi Liu, Zhongtao Jia, Chuanzao Mao, Lixing Yuan

Journal: Plant&cell physiology

PubMed ID: 35861152

Doi: 10.1093/pcp/pcac104

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Antigenic characterization of the SARS-CoV-2 Omicron subvariant BA275

Authors: Qian Wang, Sho Iketani, Zhiteng Li, Yicheng Guo, Andre Yanchen Yeh, Michael Liu, Jian Yu, Zizhang Sheng, Yaoxing Huang, Lihong Liu, David D Ho

Journal: Cell Host Microbe

PubMed ID: 36108630

Doi: 10.1016/j.chom.2022.09.002

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Activated AMP-activated protein kinase prevents hepatic steatosis, oxidative stress and inflammation in primary chicken hepatocytes

Authors: Yao Yao, Longlong Li, Huihui Wang, Ying Yang, Haitian Ma

Journal: Front Physiol

PubMed ID: 36160867

Doi: 10.3389/fphys.2022.974825

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Heterologous Expression and Catalytic Properties of Codon-Optimized Small-Sized Bromelain from MD2 Pineapple

Authors: Rafida Razali, Fikran Aranda Fahrudin, Vijay Kumar Subbiah, Kazufumi Takano, Cahyo Budiman

Journal: Molecules

PubMed ID: 36144767

Doi: 10.3390/molecules27186031

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A nuclear import pathway exploited by pathogenic noncoding RNAs

Authors: Junfei Ma, Shachinthaka D Dissanayaka Mudiyanselage, Woong June Park, Mo Wang, Ryuta Takeda, Bin Liu, Ying Wang

Journal: Plant Cell

PubMed ID: 35877068

Doi: 10.1093/plcell/koac210

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Dynamic Actin Filament Traps Mediate Active Diffusion of Vesicular Stomatitis Virus Ribonucleoproteins

Authors: Steven J Moran, Shelby Puckett, David A Ornelles, Jed C Macosko, George Holzwarth, Douglas S Lyles

Journal: J Virol

PubMed ID: 36135365

Doi: 10.1128/jvi.00934-22

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The CD4 T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn's disease

Authors: Thomas K Pedersen, Eric M Brown, Damian R Plichta, Joachim Johansen, Shaina W Twardus, Toni M Delorey, Helena Lau, Hera Vlamakis, James J Moon, Ramnik J Xavier, Daniel B Graham

Journal: Immunity

PubMed ID: 36115338

Doi: 10.1016/j.immuni.2022.08.016

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Vaspin Ameliorates Cardiac Remodeling by Suppressing Phosphoinositide 3-Kinase/Protein Kinase B Pathway to Improve Oxidative Stress in Heart Failure Rats

Authors: Mingyue Ji, Yong Li, Yun Liu, Genshan Ma

Journal: J Cardiovasc Pharmacol

PubMed ID: 36067399

Doi: 10.1097/FJC.0000000000001291

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Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish

Authors: Josiah D Zoodsma, Emma J Keegan, Gabrielle R Moody, Ashwin A Bhandiwad, Amalia J Napoli, Harold A Burgess, Lonnie P Wollmuth, Howard I Sirotkin

Journal: Mol Autism

PubMed ID: 36138431

Doi: 10.1186/s13229-022-00516-3

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Overexpression of NDST1 Attenuates Fibrotic Response in Murine Adipose-Derived Stem Cells

Authors: Takayoshi Otsuka, Ho-Man Kan, Timothy D Mason, Lakshmi S Nair, Cato T Laurencin

Journal: Stem Cells Dev

PubMed ID: 35920108

Doi: 10.1089/scd.2022.0053

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Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern

Authors: Peifang Sun, Irene Ramos, Camila H Coelho, Alba Grifoni, Corey A Balinsky, Sindhu Vangeti, Alison Tarke, Nathaniel I Bloom, Vihasi Jani, Silvia J Jakubski, David A Boulifard, Elizabeth Cooper, Carl W Goforth, Jan Marayag, Amethyst Marrone, Edgar Nunez, Lindsey White, Chad K Porter, Victor A Sugiharto, Megan Schilling, Avinash S Mahajan, Charmagne Beckett, Alessandro Sette, Stuart C Sealfon, Shane Crotty, Andrew G Letizia

Journal: iScience

PubMed ID: 36168391

Doi: 10.1016/j.isci.2022.105202

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Utilization of the Abbott SARS-CoV-2 IgG II Quant Assay To Identify High-Titer Anti-SARS-CoV-2 Neutralizing Plasma against Wild-Type and Variant SARS-CoV-2 Viruses

Authors: Yi-Chan J Lin, David H Evans, Ninette F Robbins, Guillermo Orjuela, Queenie Hu, Reuben Samson, Kento T Abe, Bhavisha Rathod, Karen Colwill, Anne-Claude Gingras, Ashleigh Tuite, Qi-Long Yi, Sheila F O'Brien, Steven J Drews

Journal: Microbiol Spectr

PubMed ID: 36125288

Doi: 10.1128/spectrum.02811-22

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Nanobody-based RFP-dependent Cre recombinase for selective anterograde tracing in RFP-expressing transgenic animals

Authors: Ayumu Inutsuka, Sho Maejima, Hiroyuki Mizoguchi, Ryosuke Kaneko, Rei Nomura, Keiko Takanami, Hirotaka Sakamoto, Tatsushi Onaka

Journal: Commun Biol

PubMed ID: 36114373

Doi: 10.1038/s42003-022-03944-2

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A bead-based method for high-throughput mapping of the sequence- and force-dependence of T cell activation

Authors: Yinnian Feng, Xiang Zhao, Adam K White, K Christopher Garcia, Polly M Fordyce

Journal: Nat Methods

PubMed ID: 36064771

Doi: 10.1038/s41592-022-01592-2

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A new blocking ELISA for detection of foot-and-mouth disease non-structural protein (NSP) antibodies in a broad host range

Authors: Madhusudan Hosamani, Shreya Gopinath, B P Sreenivasa, Subhasmita Behera, Suresh H Basagoudanavar, Ashok Boora, Durlav P Bora, Pankaj Deka, Veerakyathappa Bhanuprakash, Raj Kumar Singh, Aniket Sanyal, Klaas Weerdmeester, Aldo Dekker

Journal: Appl Microbiol Biotechnol

PubMed ID: 36089639

Doi: 10.1007/s00253-022-12151-2

Products & Services: Proteins, Expression, Isolation and Analysis

Synthetic evolution of herbicide resistance using a T7 RNAP-based random DNA base editor

Authors: Haroon Butt, Jose Luis Moreno Ramirez, Magdy Mahfouz

Journal: Life Sci Alliance

PubMed ID: 36171140

Doi: 10.26508/lsa.202201538

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