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Metabolomic analysis of rapeseed priming with H2O2 in response to germination under chilling stress
Authors: Zhiwei Gu, Duan Wang, Qingtao Gong, Juan You, Qingji Ren, Haimei An, Yongyin Zhou, Haidong Jiang
Journal: Plant Growth Regulation
Doi: 10.1007/s10725-022-00918-6
Products & Services: Gene Synthesis   
Observation of conformational changes that underlie the catalytic cycle of Xrn2
Authors: Jan H Overbeck, David Stelzig, Anna-Lisa Fuchs, Jan Philip Wurm, Remco Sprangers
Journal: Nature Chemical Biology
PubMed ID: 36008487
Doi: 10.1038/s41589-022-01111-6
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A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin
Authors: Qiyao Chai , Shanshan Yu, Yanzhao Zhong , Zhe Lu , Changgen Qiu, Yang Yu , Xinwen Zhang , Yong Zhang, Zehui Lei, Lihua Qiang, Bing-Xi Li, Yu Pang, Xiao-Bo Qiu, Jing Wang , Cui Hua Liu
Journal: Science .
PubMed ID: 36227980
Doi: 10.1126/science.abq0132
Products & Services: DNA Sequencing   Peptide Synthesis   
Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
Authors: Oguz Bolgi, Maria Silva-Garcia, Breyan Ross, Esther Pilla, Vijayalakshmi Kari, Markus Killisch, Melanie Spitzner, Nadine Stark, Christof Lenz, Konstantin Weiss, Laura Donzelli, Mark D Gorrell, Marian Grade, Jan Riemer, Henning Urlaub, Matthias Dobbelstein, Robert Huber, Ruth Geiss-Friedlander
Journal: EMBO Reports
Doi: 10.15252/embr.202154136
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Correction to: Selection of DNA aptamer and its application as an electrical biosensor for Zika virus detection in human serum
Authors: Goeun Park, Myoungro Lee, Jiatong Kang, Chulwhan Park, Junhong Min, Taek Lee
Journal: Nano Converg
PubMed ID: 36315359
Doi: 10.1186/s40580-022-00340-8
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Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance
Authors: Jaël S Copier , Marianne Bootsma , Chai A Ng , Arthur A M Wilde , Robin A Bertels , Hennie Bikker , Imke Christiaans , Saskia N van der Crabben , Janna A Hol , Tamara T Koopmann , Jeroen Knijnenburg , Aafke A J Lommerse , Jasper J van der Smagt , Connie R Bezzina , Jamie I Vandenberg , Arie O Verkerk , Daniela Q C M Barge-Schaapveld , Elisabeth M Lodder
Journal: Hum Mol Genet
PubMed ID: 36269083
Doi: 10.1093/hmg/ddac261
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Available online 28 June 2022 0925-4005/© 2022 Elsevier B.V. All rights reserved. A universal CRISPR/Cas12a-mediated AuNPs aggregation-based surface-enhanced Raman scattering (CRISPR/Cas-SERS) platform for virus gene detection
Authors: Ailing Su , Yuan Liu , Xiumian Cao , Weiqing Xu , Chongyang Liang , Shuping Xu
Journal: Sensors and Actuators B: Chemical
Doi: 10.1016/j.snb.2022.132295
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Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein
Authors: Xiaodong Luan, Xinming Li, Yufan Li, Gengchen Su, Wanchao Yin, Yi Jiang, Ning Xu, Feng Wang, Wang Cheng, Ye Jin, Leike Zhang, H. Eric Xu, Yi Xue, Shuyang Zhang
Journal: Science Bulletin
Doi: 10.1016/j.scib.2022.10.021
Products & Services: Gene Synthesis   
The PSI Domain of the MET Oncogene Encodes a Functional Disulfide Isomerase Essential for the Maturation of the Receptor Precursor
Authors: Dogus Murat Altintas, Simona Gallo, Cristina Basilico, Marina Cerqua, Alessio Bocedi, Annapia Vitacolonna, Orsola Botti, Elena Casanova, Ilaria Rancati, Chiara Milanese, Sara Notari, Giorgia Gambardella, Giorgio Ricci, Pier Giorgio Mastroberardino, Carla Boccaccio, Tiziana Crepaldi, Paolo Maria Comoglio
Journal: Int J Mol Sci
PubMed ID: 36293286
Doi: 10.3390/ijms232012427
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EP-Pred: A Machine Learning Tool for Bioprospecting Promiscuous Ester Hydrolases
Authors: Ruite Xiang, Laura Fernandez-Lopez, Ana Robles-Martín, Manuel Ferrer, Victor Guallar
Journal: Biomolecules
PubMed ID: 36291739
Doi: 10.3390/biom12101529
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N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation
Authors: Yuhang Li, Yitian Li, Sennan Xu, Yue Chen, Pan Zhou, Ting Hu, Hua Li, Ying Liu, Yaping Xu, Jie Ren, Yan Qiu, Canzhong Lu
Journal: Pharmacol Res
PubMed ID: 36244543
Doi: 10.1016/j.phrs.2022.106491
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Genetic variation in gene linked to predisposition of T2DM: A case control study
Authors: Archna Bhargave, Kiran Devi, Imteyaz Ahmad, Anita Yadav, Ranjan Gupta
Journal: J Diabetes Metab Disord
PubMed ID: 36249912
Doi: 10.1007/s40200-022-01131-y
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NAC Transcription Factor Improved Drought Stress Tolerance in Soybean
Authors: Chengfeng Yang, Yanzhong Huang, Peiyun Lv, Augustine Antwi-Boasiako, Naheeda Begum, Tuanjie Zhao, Jinming Zhao
Journal: Int J Mol Sci
PubMed ID: 36233329
Doi: 10.3390/ijms231912029
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Rescue of the first alphanucleorhabdovirus entirely from cloned complementary DNA: An efficient vector for systemic expression of foreign genes in maize and insect vectors
Authors: Surapathrudu Kanakala, César A D Xavier, Kathleen M Martin, Hong Hanh Tran, Margaret G Redinbaugh, Anna E Whitfield
Journal: Mol Plant Pathol
PubMed ID: 36239302
Doi: 10.1111/mpp.13273
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High-throughput genome editing in rice with a virus-based surrogate system
Authors: Yifu Tian, Dating Zhong, Xinbo Li, Rundong Shen, Han Han, Yuqin Dai, Qi Yao, Xuening Zhang, Qi Deng, Xuesong Cao, Jian-Kang Zhu, Yuming Lu
Journal: J Integr Plant Biol
PubMed ID: 36218268
Doi: 10.1111/jipb.13381
Immunogenicity and reactogenicity of a third dose of BNT162b2 vaccine for COVID-19 after a primary regimen with BBIBP-CorV or BNT162b2 vaccines in Lima, Peru
Authors: Natalia Vargas-Herrera, Manuel Fernández-Navarro, Nestor E Cabezudo, Percy Soto-Becerra, Gilmer Solís-Sánchez, Stefan Escobar-Agreda, Javier Silva-Valencia, Luis Pampa-Espinoza, Ricardo Bado-Pérez, Lely Solari, Roger V Araujo-Castillo
Journal: PLoS ONE
PubMed ID: 36251630
Doi: 10.1371/journal.pone.0268419
Lysyl-tRNA synthetase, a target for urgently needed M tuberculosis drugs
Authors: Simon R Green, Susan H Davis, Sebastian Damerow, Curtis A Engelhart, Michael Mathieson, Beatriz Baragaña, David A Robinson, Jevgenia Tamjar, Alice Dawson, Fabio K Tamaki, Kirsteen I Buchanan, John Post, Karen Dowers, Sharon M Shepherd, Chimed Jansen, Fabio Zuccotto, Ian H Gilbert, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Maria Osuna-Cabello, Esther Pérez-Herrán, María José Rebollo, Laura Guijarro López, Patricia Casado Castro, Isabel Camino, Heather C Kim, James M Bean, Navid Nahiyaan, Kyu Y Rhee, Qinglan Wang, Vee Y Tan, Helena I M Boshoff, Paul J Converse, Si-Yang Li, Yong S Chang, Nader Fotouhi, Anna M Upton, Eric L Nuermberger, Dirk Schnappinger, Kevin D Read, Lourdes Encinas, Robert H Bates, Paul G Wyatt, Laura A T Cleghorn
Journal: Nat Commun
PubMed ID: 36220877
Doi: 10.1038/s41467-022-33736-5
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Bioelectrocatalytic CO Reduction by Redox Polymer-Wired Carbon Monoxide Dehydrogenase Gas Diffusion Electrodes
Authors: Jana M Becker, Anna Lielpetere, Julian Szczesny, João R C Junqueira, Patricia Rodríguez-Maciá, James A Birrell, Felipe Conzuelo, Wolfgang Schuhmann
Journal: ACS Appl Mater Interfaces
PubMed ID: 36194638
Doi: 10.1021/acsami.2c09547
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Regulation of PaRBOH1-mediated ROS production in Norway spruce by Ca binding and phosphorylation
Authors: Kaloian Nickolov, Adrien Gauthier, Kenji Hashimoto, Teresa Laitinen, Enni Väisänen, Tanja Paasela, Rabah Soliymani, Takamitsu Kurusu, Kristiina Himanen, Olga Blokhina, Kurt V Fagerstedt, Soile Jokipii-Lukkari, Hannele Tuominen, Hely Häggman, Gunnar Wingsle, Teemu H Teeri, Kazuyuki Kuchitsu, Anna Kärkönen
Journal: Front Plant Sci
PubMed ID: 36311083
Doi: 10.3389/fpls.2022.978586
Characterization of a GH5 endoxylanase from Penicillium funiculosum and its synergism with GH16 endo-1,3(4)-glucanase in saccharification of sugarcane bagasse
Authors: Olusola A Ogunyewo, Omoaruemike E Okereke, Sandeep Kumar, Syed Shams Yazdani
Journal: Sci Rep
PubMed ID: 36241677
Doi: 10.1038/s41598-022-21529-1
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Nitric Oxide Negatively Regulates the Rapid Formation of Primordia by Inhibiting the Mitochondrial Gene
Authors: Ludan Hou, Chenyang Huang, Xiangli Wu, Jinxia Zhang, Mengran Zhao
Journal: J Fungi (Basel)
PubMed ID: 36294620
Doi: 10.3390/jof8101055
Molecular architecture of the glycogen- committed PP1/PTG holoenzyme
Authors: Marta Stefania Semrau, Gabriele Giachin, Sonia Covaceuszach, Alberto Cassetta, Nicola Demitri, Paola Storici, Graziano Lolli
Journal: Nat Commun
PubMed ID: 36261419
Doi: 10.1038/s41467-022-33693-z
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Author Correction: [C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease
Authors: Tharick A Pascoal, Mira Chamoun, Elad Lax, Hsiao-Ying Wey, Monica Shin, Kok Pin Ng, Min Su Kang, Sulantha Mathotaarachchi, Andrea L Benedet, Joseph Therriault, Firoza Z Lussier, Frederick A Schroeder, Jonathan M DuBois, Baileigh G Hightower, Tonya M Gilbert, Nicole R Zürcher, Changning Wang, Robert Hopewell, Mallar Chakravarty, Melissa Savard, Emilie Thomas, Sara Mohaddes, Sarah Farzin, Alyssa Salaciak, Stephanie Tullo, A Claudio Cuello, Jean-Paul Soucy, Gassan Massarweh, Heungsun Hwang, Eliane Kobayashi, Bradley T Hyman, Bradford C Dickerson, Marie-Christine Guiot, Moshe Szyf, Serge Gauthier, Jacob M Hooker, Pedro Rosa-Neto
Journal: Nat Commun
PubMed ID: 36192402
Doi: 10.1038/s41467-022-33668-0
SRC-3 deficiency prevents atherosclerosis development by decreasing endothelial ICAM-1 expression to attenuate macrophage recruitment
Authors: Wenbo Chen, Wuyang Zheng, Shixiao Liu, Qiang Su, Kangxi Ding, Ziguan Zhang, Ping Luo, Yong Zhang, Jianming Xu, Chundong Yu, Weihua Li, Zhengrong Huang
Journal: Int J Biol Sci
PubMed ID: 36263184
Doi: 10.7150/ijbs.74864
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Characterization of proteases from Irpex lacteus grown on minimally denatured soybean meals
Authors: Xiaoxu Zhu, Yufei Hua, Xiangzhen Kong, Xingfei Li, Yeming Chen, Caimeng Zhang
Journal: J Sci Food Agric
PubMed ID: 36317244
Doi: 10.1002/jsfa.12301
Crystal Structures of Epstein-Barr Virus Bcl-2 Homolog BHRF1 Bound to Bid and Puma BH3 Motif Peptides
Authors: Chathura D Suraweera, Mark G Hinds, Marc Kvansakul
Journal: Viruses
PubMed ID: 36298777
Doi: 10.3390/v14102222
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Greater Phosphorylation of AMPK and Multiple AMPK Substrates in the Skeletal Muscle of 24 Month-old Calorie Restricted Compared to Ad Libitum Fed Male Rats
Authors: Amy Zheng, Seong Eun Kwak, Jesper B Birk, Edward B Arias, Dominic Thorley, Jørgen F P Wojtaszewski, Gregory D Cartee
Journal: J Gerontol A Biol Sci Med Sci
PubMed ID: 36269629
Doi: 10.1093/gerona/glac218
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Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity
Authors: Sujith Rajan, Peter Hofer, Amanda Christiano, Matthew Stevenson, Louis Ragolia, Eugenia Villa-Cuesta, Susan K Fried, Raymond Lau, Collin Braithwaite, Rudolf Zechner, Gary J Schwartz, M Mahmood Hussain
Journal: Metabolism
PubMed ID: 36228741
Doi: 10.1016/j.metabol.2022.155331
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COX7A2L genetic variants determine cardiorespiratory fitness in mice and human
Authors: Giorgia Benegiamo, Maroun Bou Sleiman, Martin Wohlwend, Sandra Rodríguez-López, Ludger J E Goeminne, Pirkka-Pekka Laurila, Marie Klevjer, Minna K Salonen, Jari Lahti, Pooja Jha, Sara Cogliati, José Antonio Enriquez, Ben M Brumpton, Anja Bye, Johan G Eriksson, Johan Auwerx
Journal: Nat Metab
PubMed ID: 36253618
Doi: 10.1038/s42255-022-00655-0
Products & Services: Mammalian Expression   
Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack
Authors: Shuang Yang, Giorgos Hiotis, Yi Wang, Junjian Chen, Jia-Huai Wang, Mikyung Kim, Ellis L Reinherz, Thomas Walz
Journal: Nat Commun
PubMed ID: 36302771
Doi: 10.1038/s41467-022-34008-y
Achieving regioselective materials binding using multidomain peptides
Authors: Ruitao Jin, Nermina Brljak, Robert Sangrigoli, Tiffany R Walsh, Marc R Knecht
Journal: Nanoscale
PubMed ID: 36073151
Doi: 10.1039/d2nr03169h
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Tannin Reduces the Incidence of Polyspermic Penetration in Porcine Oocytes
Authors: Jing-Tao Sun, Jia-Hui Liu, Xi-Qing Jiang, Xin Luo, Jin-Dong Yuan, Qi Zhang, Xin-Yue Qi, Sanghoon Lee, Zhong-Hua Liu, Jun-Xue Jin
Journal: Antioxidants (Basel)
PubMed ID: 36290750
Doi: 10.3390/antiox11102027
Immunization with CRT-Induced Protective Immunity against Infection in BALB/c Mice
Authors: Lujuan Chen, Zhe Cheng, Siqi Xian, Bin Zhan, Zhijian Xu, Yan Yan, Jianfang Chen, Yanhai Wang, Limei Zhao
Journal: Trop Med Infect Dis
PubMed ID: 36288020
Doi: 10.3390/tropicalmed7100279
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Phytoremediation of isoproturon-contaminated sites by transgenic soybean
Authors: Xiangkun Kong, Na Lv, Songmeng Liu, Hui Xu, Junwei Huang, Xiangting Xie, Qing Tao, Baozhan Wang, Rong Ji, Qun Zhang, Jiandong Jiang
Journal: Plant Biotechnol J
PubMed ID: 36278914
Doi: 10.1111/pbi.13951
Supramolecular Assembly and Small-Molecule Binding by Protein-Engineered Coiled-Coil Fibers
Authors: Dustin Britton, Julia Monkovic, Sihan Jia, Chengliang Liu, Farbod Mahmoudinobar, Michael Meleties, P Douglas Renfrew, Richard Bonneau, Jin Kim Montclare
Journal: Biomacromolecules
PubMed ID: 36227640
Doi: 10.1021/acs.biomac.2c01031
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Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparum
Authors: Ajit Kumar Singh, Margaret Phillips, Saleh Alkrimi, Marco Tonelli, Samuel P Boyson, Kiera L Malone, Jay C Nix, Karen C Glass
Journal: Int J Biol Macromol
PubMed ID: 36328269
Doi: 10.1016/j.ijbiomac.2022.10.247
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Predicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry
Authors: Tom Dixon, Derek MacPherson, Barmak Mostofian, Taras Dauzhenka, Samuel Lotz, Dwight McGee, Sharon Shechter, Utsab R Shrestha, Rafal Wiewiora, Zachary A McDargh, Fen Pei, Rajat Pal, João V Ribeiro, Tanner Wilkerson, Vipin Sachdeva, Ning Gao, Shourya Jain, Samuel Sparks, Yunxing Li, Alexander Vinitsky, Xin Zhang, Asghar M Razavi, István Kolossváry, Jason Imbriglio, Artem Evdokimov, Louise Bergeron, Wenchang Zhou, Jagat Adhikari, Benjamin Ruprecht, Alex Dickson, Huafeng Xu, Woody Sherman, Jesus A Izaguirre
Journal: Nat Commun
PubMed ID: 36202813
Doi: 10.1038/s41467-022-33575-4
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LncRNA XIST from the bone marrow mesenchymal stem cell derived exosome promotes osteosarcoma growth and metastasis through miR-655/ACLY signal
Authors: Guanghui Zhu, Yu Xia, Ziyue Zhao, Aoyu Li, Hui Li, Tao Xiao
Journal: Cancer Cell Int
PubMed ID: 36309693
Doi: 10.1186/s12935-022-02746-0
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Development of CD163 receptor-based enzyme-linked immunosorbent assay for diagnosis of porcine reproductive and respiratory syndrome virus
Authors: Rajib Deb, Ajay Kumar Yadav, Gyanendra Singh Sengar, Joyshikh Sonowal, D Lalita, Seema Rani Pegu, Indra Singh, Ningthoukhongjam Linda, Pranab Jyoti Das, Satish Kumar, Prasanna Pal, Souvik Paul, Swaraj Rajkhowa, Vivek Kumar Gupta
Journal: 3 Biotech
PubMed ID: 36276438
Doi: 10.1007/s13205-022-03376-z
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Structural and molecular determinants of Candida glabrata metacaspase maturation and activation by calcium
Authors: Léa Conchou, Bastien Doumèche, Frédéric Galisson, Sébastien Violot, Chloé Dugelay, Eric Diesis, Adeline Page, Anne-Lise Bienvenu, Stéphane Picot, Nushin Aghajari, Lionel Ballut
Journal: Commun Biol
PubMed ID: 36316540
Doi: 10.1038/s42003-022-04091-4
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APC/CCdc20-mediated degradation of Clb4 prompts astral microtubule stabilization at anaphase onset
Authors: Federico Zucca, Clara Visintin, Jiaming Li, Steven P Gygi, Rosella Visintin
Journal: J Cell Biol
PubMed ID: 36269172
Doi: 10.1083/jcb.202203089
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Development of a simple PCR-RFLP technique for detection and differentiation of E histolytica, E dispar and E moshkovskii
Authors: Sanjib K Sardar, Seiki Kobayashi, Koushik Das, Yumiko Saito-Nakano, Shanta Dutta, Tomoyoshi Nozaki, Sandipan Ganguly
Journal: Parasitol Res
PubMed ID: 36308533
Doi: 10.1007/s00436-022-07706-1
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Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif
Authors: Wenwen Ru, Tomoyuki Koga, Xiaoyang Wang, Qiong Guo, Micah D Gearhart, Shidong Zhao, Mark Murphy, Hiroko Kawakami, Dylan Corcoran, Jiahai Zhang, Zhongliang Zhu, Xuebiao Yao, Yasuhiko Kawakami, Chao Xu
Journal: J Biol Chem
PubMed ID: 36257403
Doi: 10.1016/j.jbc.2022.102607
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Efficacy and Safety of a Brain-Penetrant Biologic TNF-α Inhibitor in Aged APP/PS1 Mice
Authors: Weijun Ou, Yuu Ohno, Joshua Yang, Devaraj V Chandrashekar, Tamara Abdullah, Jiahong Sun, Riley Murphy, Chuli Roules, Nataraj Jagadeesan, David H Cribbs, Rachita K Sumbria
Journal: Pharmaceutics
PubMed ID: 36297637
Doi: 10.3390/pharmaceutics14102200
Molecular cloning and characterization of a novel bifunctional cellobiohydrolase/β-xylosidase from a metagenomic library of mangrove soil
Authors: Yi-De Liu, Ge Yuan, Yu-Ting An, Zi-Ran Zhu, Gang Li
Journal: Enzyme Microb Technol
PubMed ID: 36265247
Doi: 10.1016/j.enzmictec.2022.110141
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Intrinsically disordered protein regions are required for cell wall homeostasis in
Authors: Yannick R Brunet, Cameron Habib, Anna P Brogan, Lior Artzi, David Z Rudner
Journal: Genes Dev
PubMed ID: 36265902
Doi: 10.1101/gad.349895.122
Oxidative Stress Amelioration of Novel Peptides Extracted from Enzymatic Hydrolysates of Chinese Pecan Cake
Authors: Jiaojiao Zhang, Shaozhen Wu, Qingqing Wang, Qinjie Yuan, Yane Li, Patricia Reboredo-Rodríguez, Alfonso Varela-López, Zhiping He, Fenghua Wu, Hao Hu, Xingquan Liu
Journal: Int J Mol Sci
PubMed ID: 36292968
Doi: 10.3390/ijms232012086
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CP12 fine-tunes the Calvin-Benson cycle and carbohydrate metabolism in cyanobacteria
Authors: Stefan Lucius, Marius Theune, Stéphanie Arrivault, Sarah Hildebrandt, Conrad W Mullineaux, Kirstin Gutekunst, Martin Hagemann
Journal: Front Plant Sci
PubMed ID: 36330266
Doi: 10.3389/fpls.2022.1028794
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Ablation of CD8 T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA1, BA2 and BA3
Authors: Srividhya Swaminathan, Katie E Lineburg, Archana Panikkar, Jyothy Raju, Lawton D Murdolo, Christopher Szeto, Pauline Crooks, Laetitia Le Texier, Sweera Rehan, Michael J Dewar-Oldis, Peter J Barnard, George R Ambalathingal, Michelle A Neller, Kirsty R Short, Stephanie Gras, Rajiv Khanna, Corey Smith
Journal: Nat Commun
PubMed ID: 36302758
Doi: 10.1038/s41467-022-34180-1
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Development of a Factor VII Activating Protease (FSAP) generation assay and its application in studying FSAP in venous thrombosis
Authors: Michael Etscheid, Kay-Martin Hanschmann, Per Morten Sandset, Sandip M Kanse
Journal: Thromb Res
PubMed ID: 36265411
Doi: 10.1016/j.thromres.2022.09.027
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A new family of CRISPR-type V nucleases with C-rich PAM recognition
Authors: Tomas Urbaitis, Giedrius Gasiunas, Joshua K Young, Zhenglin Hou, Sushmitha Paulraj, Egle Godliauskaite, Mantvyda M Juskeviciene, Migle Stitilyte, Monika Jasnauskaite, Megumu Mabuchi, G Brett Robb, Virginijus Siksnys
Journal: EMBO Rep
PubMed ID: 36268581
Doi: 10.15252/embr.202255481
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Mediator subunit MED1 differentially modulates mutant thyroid hormone receptor intracellular dynamics in Resistance to Thyroid Hormone syndrome
Authors: Moyao Wang, Vincent R Roggero, Lizabeth A Allison
Journal: Mol Cell Endocrinol
PubMed ID: 36191835
Doi: 10.1016/j.mce.2022.111781
Rational Design of a Thermostable 2' -Deoxyribosyltransferase for Nelarabine Production by Prediction of Disulfide Bond Engineering Sites
Authors: Guillermo Cruz, Javier Acosta, Jose Miguel Mancheño, Jon Del Arco, Jesús Fernández-Lucas
Journal: Int J Mol Sci
PubMed ID: 36233108
Doi: 10.3390/ijms231911806
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The seroprevalence of neutralizing antibodies against the adeno-associated virus capsids in Japanese hemophiliacs
Authors: Yuji Kashiwakura, Nemekhbayar Baatartsogt, Shoji Yamazaki, Azusa Nagao, Kagehiro Amano, Nobuaki Suzuki, Tadashi Matsushita, Akihiro Sawada, Satoshi Higasa, Naoya Yamasaki, Teruhisa Fujii, Taemi Ogura, Hideyuki Takedani, Masashi Taki, Takeshi Matsumoto, Jun Yamanouchi, Michio Sakai, Masako Nishikawa, Yutaka Yatomi, Koji Yada, Keiji Nogami, Ryota Watano, Takafumi Hiramoto, Morisada Hayakawa, Nobuhiko Kamoshita, Akihiro Kume, Hiroaki Mizukami, Shizukiyo Ishikawa, Yoichi Sakata, Tsukasa Ohmori
Journal: Mol Ther Methods Clin Dev
PubMed ID: 36381300
Doi: 10.1016/j.omtm.2022.10.014
Products & Services: Plasmid DNA Preparation   
Ubiquitin proteolysis of a CDK-related kinase regulates titan cell formation and virulence in the fungal pathogen Cryptococcus neoformans
Authors: Chengjun Cao, Keyi Wang, Yina Wang, Tong-Bao Liu, Amariliz Rivera, Chaoyang Xue
Journal: Nat Commun
PubMed ID: 36302775
Doi: 10.1038/s41467-022-34151-6
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The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain
Authors: Lavanya Moparthi, Viktor Sinica, Vamsi K Moparthi, Mohamed Kreir, Thibaut Vignane, Milos R Filipovic, Viktorie Vlachova, Peter M Zygmunt
Journal: Nat Commun
PubMed ID: 36253390
Doi: 10.1038/s41467-022-33876-8
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Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology
Authors: Anika Heinze, Cara Schuldt, Sharof Khudayberdiev, Bas van Bommel, Daniela Hacker, Toni G Schulz, Ramona Stringhi, Elena Marcello, Marina Mikhaylova, Marco B Rust
Journal: Cell Mol Life Sci
PubMed ID: 36264429
Doi: 10.1007/s00018-022-04593-8
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G3BP/Rin-Binding Motifs Inserted into Flexible Regions of nsP2 Support RNA Replication of Chikungunya Virus
Authors: Sainan Wang, Andres Merits
Journal: J Virol
PubMed ID: 36226983
Doi: 10.1128/jvi.01278-22
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Preclinical evaluation of new C-11 labeled benzo-1,4-dioxane PET radiotracers for brain α2C adrenergic receptors
Authors: Santosh Alluri,Seth M. Eisenberg,Laurel A. Grisanti,Miles Tanner,Nora D. Volkow,Sung Won Kim,Kun-Eek Kil
Journal: European Journal of Medicinal Chemistry
Doi: doi.org/10.1016/j.ejmech.2022.114764
Products & Services: ORF cDNA Clones/MolecularCloud   
E2/E3‐independent ubiquitin‐like protein conjugation by Urm1 is directly coupled to cysteine persulfidation
Authors: Keerthiraju E Ravichandran , Lars Kaduhr , Bozena Skupien-Rabian , Ekaterina Shvetsova , Mikołaj Sokołowski , Ros Cisław Krutyhołowa ,Dominika Kwasna , Cindy Brachmann , Sean Lin , Sebastian Guzman Perez , Piotr Wilk , Manuel Kösters , Przemysław Grudnik , Urszula Jankowska , Sebastian A Leidel , Raffael Schaffrath , Sebastian Glatt
Journal: EMBO J
PubMed ID: 36102610
Doi: 10.15252/embj.2022111318
Products & Services: Gene Synthesis   
Engineering a powerful green cell factory for robust photoautotrophic diterpenoid production
Authors: Alexander Einhaus , Jasmin Steube , Robert Ansgar Freudenberg , Jonas Barczyk , Thomas Baier , Olaf Kruse
Journal: Metab Eng
PubMed ID: 35717002
Doi: 10.1016/j.ymben.2022.06.002
Products & Services: Gene Synthesis   
Sodium Accumulation in Infected Cells and Ion Transporters Mistargeting in Nodules of : Two Ugly Items That Hinder Coping with Salt Stress Effects
Authors: Natalia A Trifonova, Roman Kamyshinsky, Teodoro Coba de la Peña, Maria I Koroleva, Olga Kulikova, Victoria Lara-Dampier, Pavel Pashkovskiy, Mikhail Presniakov, José J Pueyo, M Mercedes Lucas, Elena E Fedorova
Journal: Int J Mol Sci
PubMed ID: 36142539
Doi: 10.3390/ijms231810618
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Characterizing the Contributions of Various Clostridium perfringens Enterotoxin Properties to and Permeability Effects
Authors: Archana Shrestha, Mauricio A Navarro, Juliann Beingesser, Anibal G Armien, Francisco A Uzal, Bruce A McClane
Journal: mSphere
PubMed ID: 36069435
Doi: 10.1128/msphere.00276-22
Products & Services: Plasmid DNA Preparation   
Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variants
Authors: Zhaochun Chen, Peng Zhang, Yumiko Matsuoka, Yaroslav Tsybovsky, Kamille West, Celia Santos, Lisa F Boyd, Hanh Nguyen, Anna Pomerenke, Tyler Stephens, Adam S Olia, Baoshan Zhang, Valeria De Giorgi, Michael R Holbrook, Robin Gross, Elena Postnikova, Nicole L Garza, Reed F Johnson, David H Margulies, Peter D Kwong, Harvey J Alter, Ursula J Buchholz, Paolo Lusso, Patrizia Farci
Journal: Cell Rep
PubMed ID: 36302375
Doi: 10.1016/j.celrep.2022.111528
Products & Services: Mammalian Expression   
Automated model-predictive design of synthetic promoters to control transcriptional profiles in bacteria
Authors: Travis L LaFleur, Ayaan Hossain, Howard M Salis
Journal: Nat Commun
PubMed ID: 36056029
Doi: 10.1038/s41467-022-32829-5
Products & Services: Custom DNA/RNA Oligos   
Effect of Foot-and-Mouth Disease Virus 2B Viroporin on Expression and Extraction of Mammalian Cell Culture Produced Foot-and-Mouth Disease Virus-like Particles
Authors: Victoria Primavera, Janine Simmons, Benjamin A Clark, John G Neilan, Michael Puckette
Journal: Vaccines (Basel)
PubMed ID: 36146583
Doi: 10.3390/vaccines10091506
Products & Services: Custom Vector Construction   
Mechanistic understanding of human SLFN11
Authors: Felix J Metzner, Simon J Wenzl, Michael Kugler, Stefan Krebs, Karl-Peter Hopfner, Katja Lammens
Journal: Nat Commun
PubMed ID: 36115853
Doi: 10.1038/s41467-022-33123-0
Viruses inhibit TIR gcADPR signaling to overcome bacterial defense
Authors: Azita Leavitt, Erez Yirmiya, Gil Amitai, Allen Lu, Jeremy Garb, Ehud Herbst, Benjamin R Morehouse, Samuel J Hobbs, Sadie P Antine, Zhen-Yu J Sun, Philip J Kranzusch, Rotem Sorek
Journal: Nature
PubMed ID: 36174646
Doi: 10.1038/s41586-022-05375-9
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Glycosyltransferase engineering and multi-glycosylation routes development facilitating synthesis of high-intensity sweetener mogrosides
Authors: Jiao Li, Shicheng Mu, Jiangang Yang, Cui Liu, Yanfei Zhang, Peng Chen, Yan Zeng, Yueming Zhu, Yuanxia Sun
Journal: iScience
PubMed ID: 36248741
Doi: 10.1016/j.isci.2022.105222
Products & Services: Mutant Libraries   
Evaluating Primary Endpoints for COVID-19 Therapeutic Trials to Assess Recovery
Authors: David J Douin, Lianne Siegel, Greg Grandits, Andrew Phillips, Neil R Aggarwal, Jason Baker, Samuel M Brown, Christina C Chang, Anna L Goodman, Birgit Grund, Elizabeth S Higgs, Catherine L Hough, Daniel D Murray, Roger Paredes, Mahesh Parmar, Sarah Pett, Mark N Polizzotto, Uriel Sandkovsky, Wesley H Self, Barnaby E Young, Abdel G Babiker, Victoria J Davey, Virginia Kan, Annetine C Gelijns, Gail Matthews, B Taylor Thompson, H Clifford Lane, James D Neaton, Jens D Lundgren, Adit A Ginde
Journal: Am J Respir Crit Care Med
PubMed ID: 35580040
Doi: 10.1164/rccm.202112-2836OC
Products & Services: Catalog Antibody   
Impact of hypertension on long-term humoral and cellular response to SARS-CoV-2 infection
Authors: Chang Chu, Anne Schönbrunn, Kristin Klemm, Volker von Baehr, Bernhard K Krämer, Saban Elitok, Berthold Hocher
Journal: Front Immunol
PubMed ID: 36119050
Doi: 10.3389/fimmu.2022.915001
DNA Prime and Recombinant Protein Boost Vaccination Confers Chickens with Enhanced Protection against Chicken Infectious Anemia Virus
Authors: Ling Liu, Mingrong Yin, Yang Li, Hong Su, Lichun Fang, Xiaolong Sun, Shuang Chang, Peng Zhao, Yixin Wang
Journal: Viruses
PubMed ID: 36298670
Doi: 10.3390/v14102115
The first molecular identification and phylogenetic analysis of tick-borne pathogens in captive wild animals from Lohi Bher zoo, Pakistan
Authors: Muhammad Uzair Mukhtar, Naveed Iqbal, Jifei Yang, Zeeshan Nawaz, Tan Li Peng
Journal: Parasitol Res
PubMed ID: 36114837
Doi: 10.1007/s00436-022-07666-6
Products & Services: DNA Sequencing   
Ras GTPase-activating proteins control neuronal circuit development in barrel cortex layer 4
Authors: Madhura S Rao, Hiromi Mizuno, Takuji Iwasato, Hidenobu Mizuno
Journal: Front Neurosci
PubMed ID: 36188467
Doi: 10.3389/fnins.2022.901774
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Engineered flavivirus vaccines control induction of crossreactive infection-enhancing and -neutralizing antibodies
Authors: Atsushi Yamanaka, Pimploy Rattanaamnuaychai, Mami Matsuda, Ryosuke Suzuki, Yoshiharu Matsuura, Masashi Tatsumi, Eiji Konishi
Journal: Vaccine
PubMed ID: 36109279
Doi: 10.1016/j.vaccine.2022.09.012
Products & Services: Mutagenesis Services   
An alternative angiosperm DGAT1 topology and potential motifs in the N-terminus
Authors: Somrutai Winichayakul, Amy Curran, Roger Moraga, Ruth Cookson, Hong Xue, Tracey Crowther, Marissa Roldan, Greg Bryan, Nick Roberts
Journal: Front Plant Sci
PubMed ID: 36186081
Doi: 10.3389/fpls.2022.951389
Products & Services: PCR Cloning and Subcloning   
Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens
Authors: John C Kraft, Minh N Pham, Laila Shehata, Mitch Brinkkemper, Seyhan Boyoglu-Barnum, Kaitlin R Sprouse, Alexandra C Walls, Suna Cheng, Mike Murphy, Deleah Pettie, Maggie Ahlrichs, Claire Sydeman, Max Johnson, Alyssa Blackstone, Daniel Ellis, Rashmi Ravichandran, Brooke Fiala, Samuel Wrenn, Marcos Miranda, Kwinten Sliepen, Philip J M Brouwer, Aleksandar Antanasijevic, David Veesler, Andrew B Ward, Masaru Kanekiyo, Marion Pepper, Rogier W Sanders, Neil P King
Journal: Cell Rep Med
PubMed ID: 36206752
Doi: 10.1016/j.xcrm.2022.100780
Products & Services: Mammalian Expression   
Color-Switchable Nanosilicon Fluorescent Probes
Authors: Huai Chen, Jiang Xu, Yaping Wang, Da Wang, Raquel Ferrer-Espada, Yutong Wang, Jingjian Zhou, Adrián Pedrazo-Tardajos, Mei Yang, Jia-Heng Tan, Xiaoyu Yang, Lei Zhang, Ilya Sychugov, Shoudeng Chen, Sara Bals, Johan Paulsson, Zhenyu Yang
Journal: ACS Nano
PubMed ID: 36107985
Doi: 10.1021/acsnano.2c07443
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The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling
Authors: Manoshi Gayen, Marc R Benoit, Qingyuan Fan, Jacob Hudobenko, Riqiang Yan
Journal: J Biol Chem
PubMed ID: 36162508
Doi: 10.1016/j.jbc.2022.102532
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An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension
Authors: Elisabeth Fuchs, Imke Rudnik-Jansen, Anders Dinesen, Denis Selnihhin, Ole Aalund Mandrup, Kader Thiam, Jørgen Kjems, Finn Skou Pedersen, Kenneth A Howard
Journal: Acta Biomater
PubMed ID: 36162760
Doi: 10.1016/j.actbio.2022.09.048
Products & Services: Plasmid DNA Preparation   
Enhanced and Potency of a T Cell Epitope in the Ebola Virus Glycoprotein Following Amino Acid Replacement at HLA-A*02:01 Binding Positions
Authors: Sylvie Chabot, Yusra Gimie, Karam Obeid, Jaekwan Kim, Clement A Meseda, Krishnamurthy Konduru, Gerardo Kaplan, Li Sheng Fowler, Jerry P Weir, Keith Peden, Marian E Major
Journal: J Virol
PubMed ID: 36069549
Doi: 10.1128/jvi.01166-21
Products & Services: Gene Synthesis   
miR-3651 Participates in the Growth Cycle of Hepatocellular Carcinoma Cells and Promotes the Malignant Metastasis via the PI3K/AKT/mTOR Signalling Pathway
Authors: Yawei Liu, Litian Hu, Qinqiang Liu, Jing Ye, Jianping Zhang
Journal: J Oncol
PubMed ID: 36245984
Doi: 10.1155/2022/5744999
Products & Services: Custom Vector Construction   
Gene Promotes Muscle Growth and Development in Meat Ducks
Authors: Tingting Zhou, Yijing Wu, Yulin Bi, Hao Bai, Yong Jiang, Guohong Chen, Guobin Chang, Zhixiu Wang
Journal: Genes (Basel)
PubMed ID: 36140742
Doi: 10.3390/genes13091574
Products & Services: DNA Sequencing   
Chaperonin CCT5 binding with porcine parvovirus NS1 promotes the interaction of NS1 and COPƐ to facilitate viral replication
Authors: Qian Du, Xuezhi Zhang, Ning Xu, Mengyu Ma, Bicheng Miao, Yong Huang, Dewen Tong
Journal: Vet Microbiol
PubMed ID: 36126504
Doi: 10.1016/j.vetmic.2022.109574
Products & Services: Monoclonal Antibody Services   
Near Infrared Emitting Semiconductor Polymer Dots for Bioimaging and Sensing
Authors: Connor Riahin, Kushani Mendis, Brandon Busick, Marcin Ptaszek, Mengran Yang, Gary Stacey, Amar Parvate, James E Evans, Jeremiah Traeger, Dehong Hu, Galya Orr, Zeev Rosenzweig
Journal: Sensors (Basel)
PubMed ID: 36236328
Doi: 10.3390/s22197218
High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development
Authors: Shalev Gihaz, Peter Gareiss, Jae-Yeon Choi, Isaline Renard, Anasuya Chattopadhyay Pal, Yulia Surovsteva, Joy E Chiu, Jose Thekkiniath, Mark Plummer, William Hungerford, Micaela L Montgomery, Alanah Hosford, Emily M Adams, Jorge D Lightfoot, David Fox, Kayode K Ojo, Bart L Staker, Kevin Fuller, Choukri Ben Mamoun
Journal: Structure
PubMed ID: 36167065
Doi: 10.1016/j.str.2022.09.001
Products & Services: Plasmid DNA Preparation   
CycC1;1 negatively modulates ABA signaling by interacting with and inhibiting ABI5 during seed germination
Authors: Jia-Xing Guo, Ru-Feng Song, Kai-Kai Lu, Yu Zhang, Hui-Hui Chen, Jia-Xin Zuo, Ting-Ting Li, Xue-Feng Li, Wen-Cheng Liu
Journal: Plant Physiol
PubMed ID: 36173345
Doi: 10.1093/plphys/kiac456
Products & Services: Polyclonal Antibody Services   
Identification of a broad lipid repertoire associated to the endothelial cell protein C receptor (EPCR)
Authors: Elena Erausquin, María Morán-Garrido, Jorge Sáiz, Coral Barbas, Gilda Dichiara-Rodríguez, Alejandro Urdiciain, Jacinto López-Sagaseta
Journal: Sci Rep
PubMed ID: 36068249
Doi: 10.1038/s41598-022-18844-y
Products & Services: Mammalian Expression   
Novel method for detecting complement C3 deposition on Staphylococcus aureus
Authors: Toska Wonfor, Shuxian Li, Rhys W Dunphy, Alex Macpherson, Jean van den Elsen, Maisem Laabei
Journal: Sci Rep
PubMed ID: 36130996
Doi: 10.1038/s41598-022-20098-7
Products & Services: GenParts™ DNA Fragments   
Phospholipase C-related catalytically inactive protein enhances cisplatin-induced apoptotic cell death
Authors: Satoshi Asano, Yuka Maetani, Yukio Ago, Takashi Kanematsu
Journal: Eur J Pharmacol
PubMed ID: 36108738
Doi: 10.1016/j.ejphar.2022.175273
Products & Services: Gene Synthesis   
TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy
Authors: Chengyang Li, Patrick Duckney, Tong Zhang, Yanshu Fu, Xin Li, Johan Kroon, Geert De Jaeger, Yunjiang Cheng, Patrick J Hussey, Pengwei Wang
Journal: Nat Commun
PubMed ID: 36163196
Doi: 10.1038/s41467-022-33402-w
Products & Services: Custom DNA/RNA Oligos   
Tumor-Intrinsic PD-L1 Exerts an Oncogenic Function through the Activation of the Wnt/β-Catenin Pathway in Human Non-Small Cell Lung Cancer
Authors: Yunxia Ma, Rumyana Marinkova, Miljana Nenkov, Lai Jin, Otmar Huber, Jürgen Sonnemann, Natália Peca, Nikolaus Gaßler, Yuan Chen
Journal: Int J Mol Sci
PubMed ID: 36232331
Doi: 10.3390/ijms231911031
Products & Services: Mammalian Expression   
Nuclear Factor Kappa B Promotes Ferritin Heavy Chain Expression in in Response to Nucleopolyhedrovirus Infection
Authors: Linbao Zhu, Yingxue Liu, Ancheng Wang, Xiya Chen, Handan Zhu, Zhihao Huang, Huihua Cao, Shihuo Liu, Jiaping Xu
Journal: Int J Mol Sci
PubMed ID: 36142290
Doi: 10.3390/ijms231810380
Products & Services: Recombinant Antibody Expression   
Removal of redox-sensitive Rubisco Activase does not alter Rubisco regulation in soybean
Authors: Christopher M Harvey, Amanda P Cavanagh, Sang Yeol Kim, David A Wright, Ron G Edquilang, Kayla S Shreeves, Juan Alejandro Perdomo, Martin H Spalding, Donald R Ort, Carl J Bernacchi, Steven C Huber
Journal: Photosynth Res
PubMed ID: 36163583
Doi: 10.1007/s11120-022-00962-3
Products & Services: Polyclonal Antibody Services   
A review post-vaccination SARS-CoV-2 serological test: Method and antibody titer response
Authors: Melania Janisha Devi, Shabarni Gaffar, Yeni Wahyuni Hartati
Journal: Anal Biochem
PubMed ID: 36122603
Doi: 10.1016/j.ab.2022.114902
Products & Services: Recombinant Proteins   
Targeting of palpable B16-F10 melanoma tumors with polyclonal antibodies on white blood cells
Authors: Girja S Shukla, Stephanie C Pero, Linda Mei, Yu-Jing Sun, David N Krag
Journal: J Immunol Methods
PubMed ID: 36174735
Doi: 10.1016/j.jim.2022.113362
Products & Services: Catalog Peptides   
Plant transcripts with long or structured uORFs in NDL2 5' UTR can escape NMD in a reinitiation independent manner
Authors: Miryam A Cymerman, Helen Saul, Ronit Farhi, Karina Vexler, Dror Gottlieb, Irina Berezin, Orit Shaul
Journal: J Exp Bot
PubMed ID: 36169317
Doi: 10.1093/jxb/erac385
Fluorescence Spectroscopy of Low-Level Endogenous β-Adrenergic Receptor Expression at the Plasma Membrane of Differentiating Human iPSC-Derived Cardiomyocytes
Authors: Philipp Gmach, Marc Bathe-Peters, Narasimha Telugu, Duncan C Miller, Paolo Annibale
Journal: Int J Mol Sci
PubMed ID: 36142320
Doi: 10.3390/ijms231810405
Products & Services: Plasmid DNA Preparation   
Herpes simplex virus lymphadenitis is associated with tumor reduction in a patient with chronic lymphocytic leukemia
Authors: Andres Chang, Anton M Sholukh, Andreas Wieland, David L Jaye, Mary Carrington, Meei-Li Huang, Hong Xie, Keith R Jerome, Pavitra Roychoudhury, Alexander L Greninger, Jean L Koff, Jonathon B Cohen, David M Koelle, Lawrence Corey, Christopher R Flowers, Rafi Ahmed
Journal: J Clin Invest
PubMed ID: 35862190
Doi: 10.1172/JCI161109
Products & Services: Peptide Synthesis   
Microarray-guided evaluation of the frequency, B-cell origins, and selectivity of human glycan-binding antibodies reveals new insights and novel antibodies
Authors: J Sebastian Temme, Jennifer A Crainic, Laura M Walker, Weizhun Yang, Zibin Tan, Xuefei Huang, Jeffrey C Gildersleeve
Journal: J Biol Chem
PubMed ID: 36087840
Doi: 10.1016/j.jbc.2022.102468
Products & Services: Plasmid DNA Preparation   
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