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Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains

Authors: Xingxing Chen, Yize Sun, Laiqiang Chen, Xiu-Sheng Chen, Mingtian Pan, Yiran Zhang, Qi Wang, Weili Yang, Peng Yin, Dajian He, Xiangyu Guo, Su Yang, Yan Zeng, Sen Yan, Xiao-Jiang Li, Shihua Li

Journal: Cell Mol Life Sci

PubMed ID: 36251080

Doi: 10.1007/s00018-022-04577-8

Products & Services: Proteins, Expression, Isolation and Analysis

Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose)

Authors: Jijin R A Kuttiyatveetil, Heddy Soufari, Morgan Dasovich, Isabel R Uribe, Manija Mirhasan, Shang-Jung Cheng, Anthony K L Leung, John M Pascal

Journal: Cell Rep

PubMed ID: 36288691

Doi: 10.1016/j.celrep.2022.111529

Products & Services: Mutant Libraries

Multiplex Detection of Antibody Landscapes to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/Influenza/Common Human Coronaviruses Following Vaccination or Infection With SARS-CoV-2 and Influenza

Authors: Zhu Nan Li, Feng Liu, Stacie Jefferson, Lauren Horner, Paul Carney, Michael D L Johnson, Jennifer P King, Emily T Martin, Richard K Zimmerman, Karen Wernli, Manjusha Gaglani, Mark Thompson, Brendan Flannery, James Stevens, Terrence Tumpey, Min Z Levine

Journal: Clin Infect Dis

PubMed ID: 35684961

Doi: 10.1093/cid/ciac472

Products & Services: Stable Cell Lines

The choroid plexus: a door between the blood and the brain for tissue-type plasminogen activator

Authors: Vincent Zuba, Jonathane Furon, Mathys Bellemain-Sagnard, Sara Martinez de Lizarrondo, Laurent Lebouvier, Marina Rubio, Yannick Hommet, Maxime Gauberti, Denis Vivien, Carine Ali

Journal: Fluids Barriers CNS

PubMed ID: 36243724

Doi: 10.1186/s12987-022-00378-0

Products & Services: Mammalian Expression

Multiple phage resistance systems inhibit infection via SIR2-dependent NAD⁺ depletion

Authors: Jeremy Garb, Anna Lopatina, Aude Bernheim, Mindaugas Zaremba, Virginijus Siksnys, Sarah Melamed, Azita Leavitt, Adi Millman, Gil Amitai, Rotem Sorek

Journal: Nat Microbiol

PubMed ID: 36192536

Doi: 10.1038/s41564-022-01207-8

Products & Services: GenParts™ DNA Fragments

Comprehensive transcription terminator atlas for Bacillus subtilis

Authors: Zachary F Mandell, Rishi K Vishwakarma, Helen Yakhnin, Katsuhiko S Murakami, Mikhail Kashlev, Paul Babitzke

Journal: Nat Microbiol

PubMed ID: 36192538

Doi: 10.1038/s41564-022-01240-7

Products & Services: Catalog Antibody

Immunogenicity of SARS-CoV-2 spike antigens derived from Beta & Delta variants of concern

Authors: Bassel Akache, Tyler M Renner, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates, Lise Deschatelets, Renu Dudani, Blair A Harrison, Christian Gervais, Jennifer J Hill, Usha D Hemraz, Edmond Lam, Sophie Régnier, Anne E G Lenferink, Yves Durocher, Michael J McCluskie

Journal: npj Vaccines

PubMed ID: 36224247

Doi: 10.1038/s41541-022-00540-7

Products & Services: Recombinant Proteins

Core-Shell Structured Chitosan-Polyethylenimine Nanoparticles for Gene Delivery: Improved Stability, Cellular Uptake, and Transfection Efficiency

Authors: Jens Casper, Laura Nicolle, Melanie Willimann, Evrim Ümit Kuzucu, Alan Tran, Perrine Robin, Pascal Detampel, Hiu Man Grisch-Chan, Beat Thöny, Jörg Huwyler, Sandrine Gerber-Lemaire

Journal: Macromol Biosci

PubMed ID: 36200651

Doi: 10.1002/mabi.202200314

Products & Services: Proteins, Expression, Isolation and Analysis

Clinical, Virologic, and Immunologic Evaluation of Symptomatic Coronavirus Disease 2019 Rebound Following Nirmatrelvir/Ritonavir Treatment

Authors: Brian P Epling, Joseph M Rocco, Kristin L Boswell, Elizabeth Laidlaw, Frances Galindo, Anela Kellogg, Sanchita Das, Allison Roder, Elodie Ghedin, Allie Kreitman, Robin L Dewar, Sophie E M Kelly, Heather Kalish, Tauseef Rehman, Jeroen Highbarger, Adam Rupert, Gregory Kocher, Michael R Holbrook, Andrea Lisco, Maura Manion, Richard A Koup, Irini Sereti

Journal: Clin Infect Dis

PubMed ID: 36200701

Doi: 10.1093/cid/ciac663

Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1

Authors: Darshika J Udawatte, Diane M Lang, Jeffrey R Currier, Carey L Medin, Alan L Rothman

Journal: Front Cell Infect Microbiol

PubMed ID: 36310878

Doi: 10.3389/fcimb.2022.926036

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A tunable metabolic valve for precise growth control and increased product formation in Pseudomonas putida

Authors: Christos Batianis, Rik P van Rosmalen, Monika Major, Cheyenne van Ee, Alexandros Kasiotakis, Ruud A Weusthuis, Vitor A P Martins Dos Santos

Journal: Metab Eng

PubMed ID: 36244546

Doi: 10.1016/j.ymben.2022.10.002

Products & Services: Codon Optimization

Isolation of a Peptide That Binds to Lytic Bacteriophage

Authors: Soo Khim Chan, Zhongchao Zhao, Samuel Penziner, Ethan Khong, David Pride, Robert T Schooley, Nicole F Steinmetz

Journal: ACS Omega

PubMed ID: 36312416

Doi: 10.1021/acsomega.2c05539

Products & Services: Peptide Synthesis

A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer

Authors: Kristin A Altwegg, Suryavathi Viswanadhapalli, Monica Mann, Dimple Chakravarty, Samaya Krishnan, Zexuan Liu, Junhao Liu, Uday P Pratap, Behnam Ebrahimi, John R Sanchez, Xiaonan Li, Shihong Ma, Ben H Park, Bindu Santhamma, Yidong Chen, Zhao Lai, Ganesh V Raj, Yaxia Yuan, Daohong Zhou, Gangadhara R Sareddy, Rajeshwar R Tekmal, Stan McHardy, Tim H-M Huang, Manjeet K Rao, Hariprasad Vankayalapati, Ratna K Vadlamudi

Journal: Cancer Res

PubMed ID: 35950923

Doi: 10.1158/0008-5472.CAN-22-0698

Products & Services: Peptide Synthesis

Fluorescence dequenching assay for the activity of TEV protease

Authors: Chathura Paththamperuma, Richard C Page

Journal: Anal Biochem

PubMed ID: 36265691

Doi: 10.1016/j.ab.2022.114954

Products & Services: Mutagenesis Services

Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition

Authors: Wei-Hung Chen, JungHyun Kim, Wei Bu, Nathan L Board, Yaroslav Tsybovsky, Yanmei Wang, Anna Hostal, Sarah F Andrews, Rebecca A Gillespie, Misook Choe, Tyler Stephens, Eun Sung Yang, Amarendra Pegu, Caroline E Peterson, Brian E Fisher, John R Mascola, Stefania Pittaluga, Adrian B McDermott, Masaru Kanekiyo, M Gordon Joyce, Jeffrey I Cohen

Journal: Immunity

PubMed ID: 36306784

Doi: 10.1016/j.immuni.2022.10.003

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BP5 alleviates endotoxemia-induced acute lung injury by activating Nrf2 via dual regulation of the Keap1-Nrf2 interaction and the Akt (Ser473)/GSK3β (Ser9)/Fyn pathway

Authors: Tianxiang Li, Zhirong Geng, Ju Zhang, Lu Xu, Xiaoli Zhu

Journal: Free Radic Biol Med

PubMed ID: 36272670

Doi: 10.1016/j.freeradbiomed.2022.10.299

Products & Services: Recombinant Proteins

Efficacy and safety of universal (TCRKO) ARI-0001 CAR-T cells for the treatment of B-cell lymphoma

Authors: Noelia Maldonado-Pérez, María Tristán-Manzano, Pedro Justicia-Lirio, Elena Martínez-Planes, Pilar Muñoz, Kristina Pavlovic, Marina Cortijo-Gutiérrez, Carlos Blanco-Benítez, María Castella, Manel Juan, Mathias Wenes, Pedro Romero, Francisco J Molina-Estévez, Concepción Marañón, Concha Herrera, Karim Benabdellah, Francisco Martin

Journal: Front Immunol

PubMed ID: 36275777

Doi: 10.3389/fimmu.2022.1011858

Products & Services: Recombinant Antibody Expression

Reverse genetics based H5N2 vaccine provides clinical protection against H5N1, H5N8 and H9N2 avian influenza infection in chickens

Authors: Sivasankar Panickan, Sandeep Bhatia, Sushant Bhat, Nisha Bhandari, Atul Kumar Pateriya, Semmannan Kalaiyarasu, Richa Sood, Meghna Tripathi

Journal: Vaccine

PubMed ID: 36374710

Doi: 10.1016/j.vaccine.2022.10.018

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Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins

Authors: Michael D Healy, Joanna Sacharz, Kerrie E McNally, Calum McConville, Vikas A Tillu, Ryan J Hall, Molly Chilton, Peter J Cullen, Mehdi Mobli, Rajesh Ghai, David A Stroud, Brett M Collins

Journal: Structure

PubMed ID: 36302387

Doi: 10.1016/j.str.2022.10.001

Products & Services: Mammalian Expression

Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant

Authors: Wei Zhang, Ke Shi, Qibin Geng, Gang Ye, Hideki Aihara, Fang Li

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36256797

Doi: 10.1073/pnas.2206509119

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Structural basis for product specificities of MLL family methyltransferases

Authors: Yanjing Li , Lijie Zhao , Yuebin Zhang , Ping Wu , Ying Xu , Jun Mencius , Yongxin Zheng , Xiaoman Wang , Wancheng Xu , Naizhe Huang , Xianwen Ye , Ming Lei , Pan Shi , Changlin Tian , Chao Peng , Guohui Li , Zhijun Liu , Shu Quan , Yong Chen

Journal: Mol Cell

PubMed ID: 36108631

Doi: 10.1016/j.molcel.2022.08.022

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Advanced pathway engineering for phototrophic putrescine production

Authors: Robert A Freudenberg , Luisa Wittemeier , Alexander Einhaus , Thomas Baier , Olaf Kruse

Journal: Plant Biotechnol J

PubMed ID: 35748533

Doi: 10.1111/pbi.13879

Products & Services: Gene Synthesis

Human melanocortin-2 receptor: Identifying a role for residues in the TM4, EC2, and TM5 domains in activation and trafficking as a result of co-expression with the accessory protein, Mrap1 in Chinese Hamster Ovary Cells.

Authors: Perry V Davis , Ciaran A Shaughnessy , Robert M Dores

Journal: Biomolecules

PubMed ID: 36291631

Doi: 10.3390/biom12101422

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Labeling Ebola Virus with a Self-Splicing Fluorescent Reporter

Authors: Baylee Heiden , Elke Mühlberger , Christopher W Lennon , Adam J Hume

Journal: Microorganisms

PubMed ID: 36363701

Doi: 10.3390/microorganisms10112110

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Crystal structure of an L-type lectin domain from archaea

Authors: Farha Khan, Kaza Suguna

Journal: Proteins

PubMed ID: 36301308

Doi: 10.1002/prot.26440

Products & Services: PCR Cloning and Subcloning

Authors: Eyby Leon, Claris Nde, Randall S Ray, Diego Preciado, Irene E Zohn

Journal: Am J Med Genet A

PubMed ID: 36263470

Doi: 10.1002/ajmg.a.62991

Products & Services: Plasmid DNA Preparation

Divergent SARS-CoV-2-specific T cell responses in intensive care unit workers following mRNA COVID-19 vaccination

Authors: Estefanía Salgado Del Riego, María Laura Saiz, Viviana Corte-Iglesias, Blanca Leoz Gordillo, Cristina Martin-Martin, Mercedes Rodríguez-Pérez, Dolores Escudero, Carlos Lopez-Larrea, Beatriz Suarez-Alvarez

Journal: Front Immunol

PubMed ID: 36275696

Doi: 10.3389/fimmu.2022.942192

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Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2

Authors: Phillip Pymm, Samuel J Redmond, Olan Dolezal, Francesca Mordant, Ester Lopez, James P Cooney, Kathryn C Davidson, Ebene R Haycroft, Chee Wah Tan, Rebecca Seneviratna, Samantha L Grimley, Damian F J Purcell, Stephen J Kent, Adam K Wheatley, Lin-Fa Wang, Andrew Leis, Alisa Glukhova, Marc Pellegrini, Amy W Chung, Kanta Subbarao, Adam P Uldrich, Wai-Hong Tham, Dale I Godfrey, Nicholas A Gherardin

Journal: iScience

PubMed ID: 36213007

Doi: 10.1016/j.isci.2022.105259

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 Transmission from Human to Pet and Suspected Transmission from Pet to Human, Thailand

Authors: Chutchai Piewbang, Panida Poonsin, Pattiya Lohavicharn, Sabrina Wahyu Wardhani, Wichan Dankaona, Jiratchaya Puenpa, Yong Poovorawan, Somporn Techangamsuwan

Journal: J Clin Microbiol

PubMed ID: 36314788

Doi: 10.1128/jcm.01058-22

Products & Services: Catalog Antibody

Antibody Response to Rotavirus C Pre-Farrow Natural Planned Exposure to Gilts and Their Piglets

Authors: Deepak Kumar, Amanda V Anderson, Jeremy Pittman, Nora L Springer, Douglas G Marthaler, Waithaka Mwangi

Journal: Viruses

PubMed ID: 36298806

Doi: 10.3390/v14102250

Products & Services: Mammalian Expression

The Therapeutic Effects of a PEDF-Derived Short Peptide on Murine Experimental Dry Eye Involves Suppression of MMP-9 and Inflammation

Authors: Tsung-Chuan Ho, Nai-Wen Fan, Shu-I Yeh, Show-Li Chen, Yeou-Ping Tsao

Journal: Transl Vis Sci Technol

PubMed ID: 36201200

Doi: 10.1167/tvst.11.10.12

Products & Services: Catalog Peptides

Deciphering the Key Regulatory Roles of KLF6 and Bta-miR-148a on Milk Fat Metabolism in Bovine Mammary Epithelial Cells

Authors: Ambreen Iqbal, Haibin Yu, Ping Jiang, Zhihui Zhao

Journal: Genes (Basel)

PubMed ID: 36292712

Doi: 10.3390/genes13101828

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Focused B cell response to recurring gluten motif with implications for epitope spreading in celiac disease

Authors: Chunyan Zhou, Thomas Østerbye, Emil Bach, Shiva Dahal-Koirala, Lene S Høydahl, Øyvind Steinsbø, Jørgen Jahnsen, Knut E A Lundin, Søren Buus, Ludvig M Sollid, Rasmus Iversen

Journal: Cell Rep

PubMed ID: 36288703

Doi: 10.1016/j.celrep.2022.111541

Products & Services: Recombinant Antibody Expression

Investigating the Role of African Horse Sickness Virus VP7 Protein Crystalline Particles on Virus Replication and Release

Authors: Shani Bekker, Christiaan A Potgieter, Vida van Staden, Jacques Theron

Journal: Viruses

PubMed ID: 36298748

Doi: 10.3390/v14102193

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Single-cell RNA sequencing analysis of shrimp immune cells identifies macrophage-like phagocytes

Authors: Peng Yang , Yaohui Chen , Zhiqi Huang , Huidan Xia , Ling Cheng , Hao Wu , Yueling Zhang , Fan Wang

Journal: Elife

PubMed ID: 36200862

Doi: 10.7554/eLife.80127

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Intracellular infection by symbiotic bacteria requires the mitotic kinase AURORA1

Authors: Jin-Peng Gao , Suyu Jiang , Yangyang Su , Ping Xu , Junjie Wang , Wenjie Liang , Cheng-Wu Liu , Jeremy D Murray

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36252014

Doi: doi.org/10.1073/pnas.2202606119

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Observation of conformational changes that underlie the catalytic cycle of Xrn2

Authors: Jan H Overbeck, David Stelzig, Anna-Lisa Fuchs, Jan Philip Wurm, Remco Sprangers

Journal: Nature Chemical Biology

PubMed ID: 36008487

Doi: 10.1038/s41589-022-01111-6

Products & Services: Codon Optimization Gene Synthesis

Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair

Authors: Oguz Bolgi, Maria Silva-Garcia, Breyan Ross, Esther Pilla, Vijayalakshmi Kari, Markus Killisch, Melanie Spitzner, Nadine Stark, Christof Lenz, Konstantin Weiss, Laura Donzelli, Mark D Gorrell, Marian Grade, Jan Riemer, Henning Urlaub, Matthias Dobbelstein, Robert Huber, Ruth Geiss-Friedlander

Journal: EMBO Reports

Doi: 10.15252/embr.202154136

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Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance

Authors: Jaël S Copier , Marianne Bootsma , Chai A Ng , Arthur A M Wilde , Robin A Bertels , Hennie Bikker , Imke Christiaans , Saskia N van der Crabben , Janna A Hol , Tamara T Koopmann , Jeroen Knijnenburg , Aafke A J Lommerse , Jasper J van der Smagt , Connie R Bezzina , Jamie I Vandenberg , Arie O Verkerk , Daniela Q C M Barge-Schaapveld , Elisabeth M Lodder

Journal: Hum Mol Genet

PubMed ID: 36269083

Doi: 10.1093/hmg/ddac261

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Metabolomic analysis of rapeseed priming with H2O2 in response to germination under chilling stress

Authors: Zhiwei Gu, Duan Wang, Qingtao Gong, Juan You, Qingji Ren, Haimei An, Yongyin Zhou, Haidong Jiang

Journal: Plant Growth Regulation

Doi: 10.1007/s10725-022-00918-6

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A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin

Authors: Qiyao Chai , Shanshan Yu, Yanzhao Zhong , Zhe Lu , Changgen Qiu, Yang Yu , Xinwen Zhang , Yong Zhang, Zehui Lei, Lihua Qiang, Bing-Xi Li, Yu Pang, Xiao-Bo Qiu, Jing Wang , Cui Hua Liu

Journal: Science .

PubMed ID: 36227980

Doi: 10.1126/science.abq0132

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Correction to: Selection of DNA aptamer and its application as an electrical biosensor for Zika virus detection in human serum

Authors: Goeun Park, Myoungro Lee, Jiatong Kang, Chulwhan Park, Junhong Min, Taek Lee

Journal: Nano Converg

PubMed ID: 36315359

Doi: 10.1186/s40580-022-00340-8

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Available online 28 June 2022 0925-4005/© 2022 Elsevier B.V. All rights reserved. A universal CRISPR/Cas12a-mediated AuNPs aggregation-based surface-enhanced Raman scattering (CRISPR/Cas-SERS) platform for virus gene detection

Authors: Ailing Su ， Yuan Liu , Xiumian Cao , Weiqing Xu , Chongyang Liang , Shuping Xu

Journal: Sensors and Actuators B: Chemical

Doi: 10.1016/j.snb.2022.132295

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Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein

Authors: Xiaodong Luan, Xinming Li, Yufan Li, Gengchen Su, Wanchao Yin, Yi Jiang, Ning Xu, Feng Wang, Wang Cheng, Ye Jin, Leike Zhang, H. Eric Xu, Yi Xue, Shuyang Zhang

Journal: Science Bulletin

Doi: 10.1016/j.scib.2022.10.021

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The PSI Domain of the MET Oncogene Encodes a Functional Disulfide Isomerase Essential for the Maturation of the Receptor Precursor

Authors: Dogus Murat Altintas, Simona Gallo, Cristina Basilico, Marina Cerqua, Alessio Bocedi, Annapia Vitacolonna, Orsola Botti, Elena Casanova, Ilaria Rancati, Chiara Milanese, Sara Notari, Giorgia Gambardella, Giorgio Ricci, Pier Giorgio Mastroberardino, Carla Boccaccio, Tiziana Crepaldi, Paolo Maria Comoglio

Journal: Int J Mol Sci

PubMed ID: 36293286

Doi: 10.3390/ijms232012427

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EP-Pred: A Machine Learning Tool for Bioprospecting Promiscuous Ester Hydrolases

Authors: Ruite Xiang, Laura Fernandez-Lopez, Ana Robles-Martín, Manuel Ferrer, Victor Guallar

Journal: Biomolecules

PubMed ID: 36291739

Doi: 10.3390/biom12101529

Products & Services: Recombinant Proteins

N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation

Authors: Yuhang Li, Yitian Li, Sennan Xu, Yue Chen, Pan Zhou, Ting Hu, Hua Li, Ying Liu, Yaping Xu, Jie Ren, Yan Qiu, Canzhong Lu

Journal: Pharmacol Res

PubMed ID: 36244543

Doi: 10.1016/j.phrs.2022.106491

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Genetic variation in gene linked to predisposition of T2DM: A case control study

Authors: Archna Bhargave, Kiran Devi, Imteyaz Ahmad, Anita Yadav, Ranjan Gupta

Journal: J Diabetes Metab Disord

PubMed ID: 36249912

Doi: 10.1007/s40200-022-01131-y

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NAC Transcription Factor Improved Drought Stress Tolerance in Soybean

Authors: Chengfeng Yang, Yanzhong Huang, Peiyun Lv, Augustine Antwi-Boasiako, Naheeda Begum, Tuanjie Zhao, Jinming Zhao

Journal: Int J Mol Sci

PubMed ID: 36233329

Doi: 10.3390/ijms231912029

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Rescue of the first alphanucleorhabdovirus entirely from cloned complementary DNA: An efficient vector for systemic expression of foreign genes in maize and insect vectors

Authors: Surapathrudu Kanakala, César A D Xavier, Kathleen M Martin, Hong Hanh Tran, Margaret G Redinbaugh, Anna E Whitfield

Journal: Mol Plant Pathol

PubMed ID: 36239302

Doi: 10.1111/mpp.13273

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High-throughput genome editing in rice with a virus-based surrogate system

Authors: Yifu Tian, Dating Zhong, Xinbo Li, Rundong Shen, Han Han, Yuqin Dai, Qi Yao, Xuening Zhang, Qi Deng, Xuesong Cao, Jian-Kang Zhu, Yuming Lu

Journal: J Integr Plant Biol

PubMed ID: 36218268

Doi: 10.1111/jipb.13381

Products & Services: Proteins, Expression, Isolation and Analysis

Immunogenicity and reactogenicity of a third dose of BNT162b2 vaccine for COVID-19 after a primary regimen with BBIBP-CorV or BNT162b2 vaccines in Lima, Peru

Authors: Natalia Vargas-Herrera, Manuel Fernández-Navarro, Nestor E Cabezudo, Percy Soto-Becerra, Gilmer Solís-Sánchez, Stefan Escobar-Agreda, Javier Silva-Valencia, Luis Pampa-Espinoza, Ricardo Bado-Pérez, Lely Solari, Roger V Araujo-Castillo

Journal: PLoS ONE

PubMed ID: 36251630

Doi: 10.1371/journal.pone.0268419

Products & Services: Proteins, Expression, Isolation and Analysis

Lysyl-tRNA synthetase, a target for urgently needed M tuberculosis drugs

Authors: Simon R Green, Susan H Davis, Sebastian Damerow, Curtis A Engelhart, Michael Mathieson, Beatriz Baragaña, David A Robinson, Jevgenia Tamjar, Alice Dawson, Fabio K Tamaki, Kirsteen I Buchanan, John Post, Karen Dowers, Sharon M Shepherd, Chimed Jansen, Fabio Zuccotto, Ian H Gilbert, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Maria Osuna-Cabello, Esther Pérez-Herrán, María José Rebollo, Laura Guijarro López, Patricia Casado Castro, Isabel Camino, Heather C Kim, James M Bean, Navid Nahiyaan, Kyu Y Rhee, Qinglan Wang, Vee Y Tan, Helena I M Boshoff, Paul J Converse, Si-Yang Li, Yong S Chang, Nader Fotouhi, Anna M Upton, Eric L Nuermberger, Dirk Schnappinger, Kevin D Read, Lourdes Encinas, Robert H Bates, Paul G Wyatt, Laura A T Cleghorn

Journal: Nat Commun

PubMed ID: 36220877

Doi: 10.1038/s41467-022-33736-5

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Bioelectrocatalytic CO Reduction by Redox Polymer-Wired Carbon Monoxide Dehydrogenase Gas Diffusion Electrodes

Authors: Jana M Becker, Anna Lielpetere, Julian Szczesny, João R C Junqueira, Patricia Rodríguez-Maciá, James A Birrell, Felipe Conzuelo, Wolfgang Schuhmann

Journal: ACS Appl Mater Interfaces

PubMed ID: 36194638

Doi: 10.1021/acsami.2c09547

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Regulation of PaRBOH1-mediated ROS production in Norway spruce by Ca binding and phosphorylation

Authors: Kaloian Nickolov, Adrien Gauthier, Kenji Hashimoto, Teresa Laitinen, Enni Väisänen, Tanja Paasela, Rabah Soliymani, Takamitsu Kurusu, Kristiina Himanen, Olga Blokhina, Kurt V Fagerstedt, Soile Jokipii-Lukkari, Hannele Tuominen, Hely Häggman, Gunnar Wingsle, Teemu H Teeri, Kazuyuki Kuchitsu, Anna Kärkönen

Journal: Front Plant Sci

PubMed ID: 36311083

Doi: 10.3389/fpls.2022.978586

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of a GH5 endoxylanase from Penicillium funiculosum and its synergism with GH16 endo-1,3(4)-glucanase in saccharification of sugarcane bagasse

Authors: Olusola A Ogunyewo, Omoaruemike E Okereke, Sandeep Kumar, Syed Shams Yazdani

Journal: Sci Rep

PubMed ID: 36241677

Doi: 10.1038/s41598-022-21529-1

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Nitric Oxide Negatively Regulates the Rapid Formation of Primordia by Inhibiting the Mitochondrial Gene

Authors: Ludan Hou, Chenyang Huang, Xiangli Wu, Jinxia Zhang, Mengran Zhao

Journal: J Fungi (Basel)

PubMed ID: 36294620

Doi: 10.3390/jof8101055

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular architecture of the glycogen- committed PP1/PTG holoenzyme

Authors: Marta Stefania Semrau, Gabriele Giachin, Sonia Covaceuszach, Alberto Cassetta, Nicola Demitri, Paola Storici, Graziano Lolli

Journal: Nat Commun

PubMed ID: 36261419

Doi: 10.1038/s41467-022-33693-z

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Author Correction: [C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease

Authors: Tharick A Pascoal, Mira Chamoun, Elad Lax, Hsiao-Ying Wey, Monica Shin, Kok Pin Ng, Min Su Kang, Sulantha Mathotaarachchi, Andrea L Benedet, Joseph Therriault, Firoza Z Lussier, Frederick A Schroeder, Jonathan M DuBois, Baileigh G Hightower, Tonya M Gilbert, Nicole R Zürcher, Changning Wang, Robert Hopewell, Mallar Chakravarty, Melissa Savard, Emilie Thomas, Sara Mohaddes, Sarah Farzin, Alyssa Salaciak, Stephanie Tullo, A Claudio Cuello, Jean-Paul Soucy, Gassan Massarweh, Heungsun Hwang, Eliane Kobayashi, Bradley T Hyman, Bradford C Dickerson, Marie-Christine Guiot, Moshe Szyf, Serge Gauthier, Jacob M Hooker, Pedro Rosa-Neto

Journal: Nat Commun

PubMed ID: 36192402

Doi: 10.1038/s41467-022-33668-0

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SRC-3 deficiency prevents atherosclerosis development by decreasing endothelial ICAM-1 expression to attenuate macrophage recruitment

Authors: Wenbo Chen, Wuyang Zheng, Shixiao Liu, Qiang Su, Kangxi Ding, Ziguan Zhang, Ping Luo, Yong Zhang, Jianming Xu, Chundong Yu, Weihua Li, Zhengrong Huang

Journal: Int J Biol Sci

PubMed ID: 36263184

Doi: 10.7150/ijbs.74864

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Characterization of proteases from Irpex lacteus grown on minimally denatured soybean meals

Authors: Xiaoxu Zhu, Yufei Hua, Xiangzhen Kong, Xingfei Li, Yeming Chen, Caimeng Zhang

Journal: J Sci Food Agric

PubMed ID: 36317244

Doi: 10.1002/jsfa.12301

Products & Services: Proteins, Expression, Isolation and Analysis

Crystal Structures of Epstein-Barr Virus Bcl-2 Homolog BHRF1 Bound to Bid and Puma BH3 Motif Peptides

Authors: Chathura D Suraweera, Mark G Hinds, Marc Kvansakul

Journal: Viruses

PubMed ID: 36298777

Doi: 10.3390/v14102222

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Greater Phosphorylation of AMPK and Multiple AMPK Substrates in the Skeletal Muscle of 24 Month-old Calorie Restricted Compared to Ad Libitum Fed Male Rats

Authors: Amy Zheng, Seong Eun Kwak, Jesper B Birk, Edward B Arias, Dominic Thorley, Jørgen F P Wojtaszewski, Gregory D Cartee

Journal: J Gerontol A Biol Sci Med Sci

PubMed ID: 36269629

Doi: 10.1093/gerona/glac218

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Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity

Authors: Sujith Rajan, Peter Hofer, Amanda Christiano, Matthew Stevenson, Louis Ragolia, Eugenia Villa-Cuesta, Susan K Fried, Raymond Lau, Collin Braithwaite, Rudolf Zechner, Gary J Schwartz, M Mahmood Hussain

Journal: Metabolism

PubMed ID: 36228741

Doi: 10.1016/j.metabol.2022.155331

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COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

Authors: Giorgia Benegiamo, Maroun Bou Sleiman, Martin Wohlwend, Sandra Rodríguez-López, Ludger J E Goeminne, Pirkka-Pekka Laurila, Marie Klevjer, Minna K Salonen, Jari Lahti, Pooja Jha, Sara Cogliati, José Antonio Enriquez, Ben M Brumpton, Anja Bye, Johan G Eriksson, Johan Auwerx

Journal: Nat Metab

PubMed ID: 36253618

Doi: 10.1038/s42255-022-00655-0

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Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack

Authors: Shuang Yang, Giorgos Hiotis, Yi Wang, Junjian Chen, Jia-Huai Wang, Mikyung Kim, Ellis L Reinherz, Thomas Walz

Journal: Nat Commun

PubMed ID: 36302771

Doi: 10.1038/s41467-022-34008-y

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Achieving regioselective materials binding using multidomain peptides

Authors: Ruitao Jin, Nermina Brljak, Robert Sangrigoli, Tiffany R Walsh, Marc R Knecht

Journal: Nanoscale

PubMed ID: 36073151

Doi: 10.1039/d2nr03169h

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Tannin Reduces the Incidence of Polyspermic Penetration in Porcine Oocytes

Authors: Jing-Tao Sun, Jia-Hui Liu, Xi-Qing Jiang, Xin Luo, Jin-Dong Yuan, Qi Zhang, Xin-Yue Qi, Sanghoon Lee, Zhong-Hua Liu, Jun-Xue Jin

Journal: Antioxidants (Basel)

PubMed ID: 36290750

Doi: 10.3390/antiox11102027

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Immunization with CRT-Induced Protective Immunity against Infection in BALB/c Mice

Authors: Lujuan Chen, Zhe Cheng, Siqi Xian, Bin Zhan, Zhijian Xu, Yan Yan, Jianfang Chen, Yanhai Wang, Limei Zhao

Journal: Trop Med Infect Dis

PubMed ID: 36288020

Doi: 10.3390/tropicalmed7100279

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Phytoremediation of isoproturon-contaminated sites by transgenic soybean

Authors: Xiangkun Kong, Na Lv, Songmeng Liu, Hui Xu, Junwei Huang, Xiangting Xie, Qing Tao, Baozhan Wang, Rong Ji, Qun Zhang, Jiandong Jiang

Journal: Plant Biotechnol J

PubMed ID: 36278914

Doi: 10.1111/pbi.13951

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Supramolecular Assembly and Small-Molecule Binding by Protein-Engineered Coiled-Coil Fibers

Authors: Dustin Britton, Julia Monkovic, Sihan Jia, Chengliang Liu, Farbod Mahmoudinobar, Michael Meleties, P Douglas Renfrew, Richard Bonneau, Jin Kim Montclare

Journal: Biomacromolecules

PubMed ID: 36227640

Doi: 10.1021/acs.biomac.2c01031

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Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparum

Authors: Ajit Kumar Singh, Margaret Phillips, Saleh Alkrimi, Marco Tonelli, Samuel P Boyson, Kiera L Malone, Jay C Nix, Karen C Glass

Journal: Int J Biol Macromol

PubMed ID: 36328269

Doi: 10.1016/j.ijbiomac.2022.10.247

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Predicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry

Authors: Tom Dixon, Derek MacPherson, Barmak Mostofian, Taras Dauzhenka, Samuel Lotz, Dwight McGee, Sharon Shechter, Utsab R Shrestha, Rafal Wiewiora, Zachary A McDargh, Fen Pei, Rajat Pal, João V Ribeiro, Tanner Wilkerson, Vipin Sachdeva, Ning Gao, Shourya Jain, Samuel Sparks, Yunxing Li, Alexander Vinitsky, Xin Zhang, Asghar M Razavi, István Kolossváry, Jason Imbriglio, Artem Evdokimov, Louise Bergeron, Wenchang Zhou, Jagat Adhikari, Benjamin Ruprecht, Alex Dickson, Huafeng Xu, Woody Sherman, Jesus A Izaguirre

Journal: Nat Commun

PubMed ID: 36202813

Doi: 10.1038/s41467-022-33575-4

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LncRNA XIST from the bone marrow mesenchymal stem cell derived exosome promotes osteosarcoma growth and metastasis through miR-655/ACLY signal

Authors: Guanghui Zhu, Yu Xia, Ziyue Zhao, Aoyu Li, Hui Li, Tao Xiao

Journal: Cancer Cell Int

PubMed ID: 36309693

Doi: 10.1186/s12935-022-02746-0

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Development of CD163 receptor-based enzyme-linked immunosorbent assay for diagnosis of porcine reproductive and respiratory syndrome virus

Authors: Rajib Deb, Ajay Kumar Yadav, Gyanendra Singh Sengar, Joyshikh Sonowal, D Lalita, Seema Rani Pegu, Indra Singh, Ningthoukhongjam Linda, Pranab Jyoti Das, Satish Kumar, Prasanna Pal, Souvik Paul, Swaraj Rajkhowa, Vivek Kumar Gupta

Journal: 3 Biotech

PubMed ID: 36276438

Doi: 10.1007/s13205-022-03376-z

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Structural and molecular determinants of Candida glabrata metacaspase maturation and activation by calcium

Authors: Léa Conchou, Bastien Doumèche, Frédéric Galisson, Sébastien Violot, Chloé Dugelay, Eric Diesis, Adeline Page, Anne-Lise Bienvenu, Stéphane Picot, Nushin Aghajari, Lionel Ballut

Journal: Commun Biol

PubMed ID: 36316540

Doi: 10.1038/s42003-022-04091-4

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APC/CCdc20-mediated degradation of Clb4 prompts astral microtubule stabilization at anaphase onset

Authors: Federico Zucca, Clara Visintin, Jiaming Li, Steven P Gygi, Rosella Visintin

Journal: J Cell Biol

PubMed ID: 36269172

Doi: 10.1083/jcb.202203089

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Development of a simple PCR-RFLP technique for detection and differentiation of E histolytica, E dispar and E moshkovskii

Authors: Sanjib K Sardar, Seiki Kobayashi, Koushik Das, Yumiko Saito-Nakano, Shanta Dutta, Tomoyoshi Nozaki, Sandipan Ganguly

Journal: Parasitol Res

PubMed ID: 36308533

Doi: 10.1007/s00436-022-07706-1

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Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif

Authors: Wenwen Ru, Tomoyuki Koga, Xiaoyang Wang, Qiong Guo, Micah D Gearhart, Shidong Zhao, Mark Murphy, Hiroko Kawakami, Dylan Corcoran, Jiahai Zhang, Zhongliang Zhu, Xuebiao Yao, Yasuhiko Kawakami, Chao Xu

Journal: J Biol Chem

PubMed ID: 36257403

Doi: 10.1016/j.jbc.2022.102607

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Efficacy and Safety of a Brain-Penetrant Biologic TNF-α Inhibitor in Aged APP/PS1 Mice

Authors: Weijun Ou, Yuu Ohno, Joshua Yang, Devaraj V Chandrashekar, Tamara Abdullah, Jiahong Sun, Riley Murphy, Chuli Roules, Nataraj Jagadeesan, David H Cribbs, Rachita K Sumbria

Journal: Pharmaceutics

PubMed ID: 36297637

Doi: 10.3390/pharmaceutics14102200

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Molecular cloning and characterization of a novel bifunctional cellobiohydrolase/β-xylosidase from a metagenomic library of mangrove soil

Authors: Yi-De Liu, Ge Yuan, Yu-Ting An, Zi-Ran Zhu, Gang Li

Journal: Enzyme Microb Technol

PubMed ID: 36265247

Doi: 10.1016/j.enzmictec.2022.110141

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Intrinsically disordered protein regions are required for cell wall homeostasis in

Authors: Yannick R Brunet, Cameron Habib, Anna P Brogan, Lior Artzi, David Z Rudner

Journal: Genes Dev

PubMed ID: 36265902

Doi: 10.1101/gad.349895.122

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Oxidative Stress Amelioration of Novel Peptides Extracted from Enzymatic Hydrolysates of Chinese Pecan Cake

Authors: Jiaojiao Zhang, Shaozhen Wu, Qingqing Wang, Qinjie Yuan, Yane Li, Patricia Reboredo-Rodríguez, Alfonso Varela-López, Zhiping He, Fenghua Wu, Hao Hu, Xingquan Liu

Journal: Int J Mol Sci

PubMed ID: 36292968

Doi: 10.3390/ijms232012086

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CP12 fine-tunes the Calvin-Benson cycle and carbohydrate metabolism in cyanobacteria

Authors: Stefan Lucius, Marius Theune, Stéphanie Arrivault, Sarah Hildebrandt, Conrad W Mullineaux, Kirstin Gutekunst, Martin Hagemann

Journal: Front Plant Sci

PubMed ID: 36330266

Doi: 10.3389/fpls.2022.1028794

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Ablation of CD8 T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA1, BA2 and BA3

Authors: Srividhya Swaminathan, Katie E Lineburg, Archana Panikkar, Jyothy Raju, Lawton D Murdolo, Christopher Szeto, Pauline Crooks, Laetitia Le Texier, Sweera Rehan, Michael J Dewar-Oldis, Peter J Barnard, George R Ambalathingal, Michelle A Neller, Kirsty R Short, Stephanie Gras, Rajiv Khanna, Corey Smith

Journal: Nat Commun

PubMed ID: 36302758

Doi: 10.1038/s41467-022-34180-1

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Development of a Factor VII Activating Protease (FSAP) generation assay and its application in studying FSAP in venous thrombosis

Authors: Michael Etscheid, Kay-Martin Hanschmann, Per Morten Sandset, Sandip M Kanse

Journal: Thromb Res

PubMed ID: 36265411

Doi: 10.1016/j.thromres.2022.09.027

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A new family of CRISPR-type V nucleases with C-rich PAM recognition

Authors: Tomas Urbaitis, Giedrius Gasiunas, Joshua K Young, Zhenglin Hou, Sushmitha Paulraj, Egle Godliauskaite, Mantvyda M Juskeviciene, Migle Stitilyte, Monika Jasnauskaite, Megumu Mabuchi, G Brett Robb, Virginijus Siksnys

Journal: EMBO Rep

PubMed ID: 36268581

Doi: 10.15252/embr.202255481

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Mediator subunit MED1 differentially modulates mutant thyroid hormone receptor intracellular dynamics in Resistance to Thyroid Hormone syndrome

Authors: Moyao Wang, Vincent R Roggero, Lizabeth A Allison

Journal: Mol Cell Endocrinol

PubMed ID: 36191835

Doi: 10.1016/j.mce.2022.111781

Products & Services: Proteins, Expression, Isolation and Analysis

Rational Design of a Thermostable 2' -Deoxyribosyltransferase for Nelarabine Production by Prediction of Disulfide Bond Engineering Sites

Authors: Guillermo Cruz, Javier Acosta, Jose Miguel Mancheño, Jon Del Arco, Jesús Fernández-Lucas

Journal: Int J Mol Sci

PubMed ID: 36233108

Doi: 10.3390/ijms231911806

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The seroprevalence of neutralizing antibodies against the adeno-associated virus capsids in Japanese hemophiliacs

Authors: Yuji Kashiwakura, Nemekhbayar Baatartsogt, Shoji Yamazaki, Azusa Nagao, Kagehiro Amano, Nobuaki Suzuki, Tadashi Matsushita, Akihiro Sawada, Satoshi Higasa, Naoya Yamasaki, Teruhisa Fujii, Taemi Ogura, Hideyuki Takedani, Masashi Taki, Takeshi Matsumoto, Jun Yamanouchi, Michio Sakai, Masako Nishikawa, Yutaka Yatomi, Koji Yada, Keiji Nogami, Ryota Watano, Takafumi Hiramoto, Morisada Hayakawa, Nobuhiko Kamoshita, Akihiro Kume, Hiroaki Mizukami, Shizukiyo Ishikawa, Yoichi Sakata, Tsukasa Ohmori

Journal: Mol Ther Methods Clin Dev

PubMed ID: 36381300

Doi: 10.1016/j.omtm.2022.10.014

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Ubiquitin proteolysis of a CDK-related kinase regulates titan cell formation and virulence in the fungal pathogen Cryptococcus neoformans

Authors: Chengjun Cao, Keyi Wang, Yina Wang, Tong-Bao Liu, Amariliz Rivera, Chaoyang Xue

Journal: Nat Commun

PubMed ID: 36302775

Doi: 10.1038/s41467-022-34151-6

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The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

Authors: Lavanya Moparthi, Viktor Sinica, Vamsi K Moparthi, Mohamed Kreir, Thibaut Vignane, Milos R Filipovic, Viktorie Vlachova, Peter M Zygmunt

Journal: Nat Commun

PubMed ID: 36253390

Doi: 10.1038/s41467-022-33876-8

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Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology

Authors: Anika Heinze, Cara Schuldt, Sharof Khudayberdiev, Bas van Bommel, Daniela Hacker, Toni G Schulz, Ramona Stringhi, Elena Marcello, Marina Mikhaylova, Marco B Rust

Journal: Cell Mol Life Sci

PubMed ID: 36264429

Doi: 10.1007/s00018-022-04593-8

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G3BP/Rin-Binding Motifs Inserted into Flexible Regions of nsP2 Support RNA Replication of Chikungunya Virus

Authors: Sainan Wang, Andres Merits

Journal: J Virol

PubMed ID: 36226983

Doi: 10.1128/jvi.01278-22

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Preclinical evaluation of new C-11 labeled benzo-1,4-dioxane PET radiotracers for brain α2C adrenergic receptors

Authors: Santosh Alluri，Seth M. Eisenberg，Laurel A. Grisanti，Miles Tanner，Nora D. Volkow，Sung Won Kim，Kun-Eek Kil

Journal: European Journal of Medicinal Chemistry

Doi: doi.org/10.1016/j.ejmech.2022.114764

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E2/E3‐independent ubiquitin‐like protein conjugation by Urm1 is directly coupled to cysteine persulfidation

Authors: Keerthiraju E Ravichandran , Lars Kaduhr , Bozena Skupien-Rabian , Ekaterina Shvetsova , Mikołaj Sokołowski , Ros Cisław Krutyhołowa ,Dominika Kwasna , Cindy Brachmann , Sean Lin , Sebastian Guzman Perez , Piotr Wilk , Manuel Kösters , Przemysław Grudnik , Urszula Jankowska , Sebastian A Leidel , Raffael Schaffrath , Sebastian Glatt

Journal: EMBO J

PubMed ID: 36102610

Doi: 10.15252/embj.2022111318

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Engineering a powerful green cell factory for robust photoautotrophic diterpenoid production

Authors: Alexander Einhaus , Jasmin Steube , Robert Ansgar Freudenberg , Jonas Barczyk , Thomas Baier , Olaf Kruse

Journal: Metab Eng

PubMed ID: 35717002

Doi: 10.1016/j.ymben.2022.06.002

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Sodium Accumulation in Infected Cells and Ion Transporters Mistargeting in Nodules of : Two Ugly Items That Hinder Coping with Salt Stress Effects

Authors: Natalia A Trifonova, Roman Kamyshinsky, Teodoro Coba de la Peña, Maria I Koroleva, Olga Kulikova, Victoria Lara-Dampier, Pavel Pashkovskiy, Mikhail Presniakov, José J Pueyo, M Mercedes Lucas, Elena E Fedorova

Journal: Int J Mol Sci

PubMed ID: 36142539

Doi: 10.3390/ijms231810618

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Characterizing the Contributions of Various Clostridium perfringens Enterotoxin Properties to and Permeability Effects

Authors: Archana Shrestha, Mauricio A Navarro, Juliann Beingesser, Anibal G Armien, Francisco A Uzal, Bruce A McClane

Journal: mSphere

PubMed ID: 36069435

Doi: 10.1128/msphere.00276-22

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Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variants

Authors: Zhaochun Chen, Peng Zhang, Yumiko Matsuoka, Yaroslav Tsybovsky, Kamille West, Celia Santos, Lisa F Boyd, Hanh Nguyen, Anna Pomerenke, Tyler Stephens, Adam S Olia, Baoshan Zhang, Valeria De Giorgi, Michael R Holbrook, Robin Gross, Elena Postnikova, Nicole L Garza, Reed F Johnson, David H Margulies, Peter D Kwong, Harvey J Alter, Ursula J Buchholz, Paolo Lusso, Patrizia Farci

Journal: Cell Rep

PubMed ID: 36302375

Doi: 10.1016/j.celrep.2022.111528

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