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A novel rhesus macaque model of Huntington's disease recapitulates key neuropathological changes along with motor and cognitive decline

Authors: Alison R Weiss, William A Liguore, Kristin Brandon, Xiaojie Wang, Zheng Liu, Jacqueline S Domire, Dana Button, Sathya Srinivasan, Christopher D Kroenke, Jodi L McBride

Journal: Elife

PubMed ID: 36205397

Doi: 10.7554/eLife.77568

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Comparative proteomic analysis reveals novel insights into the continuous cropping induced response in Scrophularia ningpoensis

Authors: Jiachen Sun, Xuejiao Li, Zhuo Qu, Huairui Wang, Yao Cheng, Shengjie Dong, Hui Zhao

Journal: J Sci Food Agric

PubMed ID: 36271763

Doi: 10.1002/jsfa.12284

Products & Services: Proteins, Expression, Isolation and Analysis

A dataset comprised of binding interactions for 104,972 antibodies against a SARS-CoV-2 peptide

Authors: Emily Engelhart, Ryan Emerson, Leslie Shing, Chelsea Lennartz, Daniel Guion, Mary Kelley, Charles Lin, Randolph Lopez, David Younger, Matthew E Walsh

Journal: Sci Data

PubMed ID: 36289234

Doi: 10.1038/s41597-022-01779-4

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ICG-Dimeric Her2-Specific Affibody Conjugates for Tumor Imaging and Photothermal Therapy for Her2-Positive Tumors

Authors: Dianlong Jia, Huimin Liu, Shuhui Zheng, Dandan Yuan, Ruohan Sun, Fei Wang, Yang Li, Hui Li, Fengjiao Yuan, Qing Fan, Zhenxiong Zhao

Journal: Mol Pharm

PubMed ID: 36315025

Doi: 10.1021/acs.molpharmaceut.2c00708

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Autophagic flux restoration enhances the antitumor efficacy of tumor infiltrating lymphocytes

Authors: Chaoting Zhang, Yizhe Sun, Shance Li, Luyan Shen, Xia Teng, Yefei Xiao, Nan Wu, Zheming Lu

Journal: J Immunother Cancer

PubMed ID: 36307150

Doi: 10.1136/jitc-2022-004868

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A method for targeting a specified segment of DNA to a bacterial microorganelle

Authors: Jan Otoničar, Maja Hostnik, Maja Grundner, Rok Kostanjšek, Tajda Gredar, Maja Garvas, Zoran Arsov, Zdravko Podlesek, Cene Gostinčar, Jernej Jakše, Stephen J W Busby, Matej Butala

Journal: Nucleic Acids Res

PubMed ID: 36029110

Doi: 10.1093/nar/gkac714

Products & Services: Proteins, Expression, Isolation and Analysis

Macromolecular crowding amplifies allosteric regulation of T-Cell Protein Tyrosine Phosphatase

Authors: May Thwe Tun, Shen Yang, Fabio Luis Forti, Eugenio Santelli, Nunzio Bottini

Journal: J Biol Chem

PubMed ID: 36328244

Doi: 10.1016/j.jbc.2022.102655

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Inhibition of Glypican-3 Cleavage Results in Reduced Cell Proliferation in a Liver Cancer Cell Line

Authors: Emily J Schepers, Charissa Lake, Kathryn Glaser, Alexander J Bondoc

Journal: J Surg Res

PubMed ID: 36272230

Doi: 10.1016/j.jss.2022.09.011

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A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers

Authors: Rongjie Cheng, Fanying Li, Maolei Zhang, Xin Xia, Jianzhuang Wu, Xinya Gao, Huangkai Zhou, Zhi Zhang, Nunu Huang, Xuesong Yang, Yaliang Zhang, Shunli Shen, Tiebang Kang, Zexian Liu, Feizhe Xiao, Hongwei Yao, Jianbo Xu, Chao Yan, Nu Zhang

Journal: Cell Res

PubMed ID: 36241718

Doi: 10.1038/s41422-022-00726-7

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Upregulation of programmed cell death 1 by interferon gamma and its biological functions in human monocytes

Authors: Kittitach Sri-Ngern-Ngam, Pornlapat Keawvilai, Trairak Pisitkun, Tanapat Palaga

Journal: Biochem Biophys Rep

PubMed ID: 36275930

Doi: 10.1016/j.bbrep.2022.101369

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Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage

Authors: Qianying Lv, Xinli Han, Jiajia Ni, Qianqian Ma, Rufeng Dai, Jiaojiao Liu, Jialu Liu, Yihui Zhai, Qian Shen, Li Sun, Haimei Liu, Jia Rao, Hong Xu

Journal: Cell Death Dis

PubMed ID: 36229446

Doi: 10.1038/s41419-022-05313-7

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DNA damage-induced nuclear import of HSP90α is promoted by Aha1

Authors: Nupur Fangaria, Khushboo Rani, Priyanka Singh, Sandeep Dey, Kota Arun Kumar, Sunanda Bhattacharyya

Journal: Mol Biol Cell

PubMed ID: 36260391

Doi: 10.1091/mbc.E21-11-0554

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A broadly protective vaccine against cutaneous human papillomaviruses

Authors: Filipe Colaco Mariz, Kathrin Balz, Manuela Dittrich, Yueru Zhang, Fan Yang, Xueer Zhao, Angelo Bolchi, Simone Ottonello, Martin Müller

Journal: npj Vaccines

PubMed ID: 36216845

Doi: 10.1038/s41541-022-00539-0

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An inducible gene from glycoside hydrolase one family of decreases larval survival when feeding on host plant

Authors: Wei Chen, Yuhong Dong, Ling Zheng, Yingfang Lai, Feifei Li, Li Zhou, Beibei Wang, Minsheng You, Weiyi He

Journal: Front Physiol

PubMed ID: 36338470

Doi: 10.3389/fphys.2022.1013092

Products & Services: Recombinant Antibody Expression

Combating the SARS-CoV-2 Omicron (BA1) and BA2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies

Authors: Yingdan Wang, Xiang Zhang, Yunping Ma, Yanqun Wang, Wuqiang Zhan, Qinwen Zheng, Meng Zhang, Ping Ji, Mei Liu, Qianying Liu, Tingting Sun, Tongyu Zhu, Yumei Wen, Lei Sun, Jincun Zhao, Fan Wu, Zhenguo Chen, Jinghe Huang

Journal: Cell Discov

PubMed ID: 36207299

Doi: 10.1038/s41421-022-00463-6

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An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation

Authors: Merve Avar, Daniel Heinzer, Alana M Thackray, Yingjun Liu, Marian Hruska-Plochan, Stefano Sellitto, Elke Schaper, Daniel P Pease, Jiang-An Yin, Asvin Kk Lakkaraju, Marc Emmenegger, Marco Losa, Andra Chincisan, Simone Hornemann, Magdalini Polymenidou, Raymond Bujdoso, Adriano Aguzzi

Journal: EMBO J

PubMed ID: 36254605

Doi: 10.15252/embj.2022112338

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Priming conditions shape breadth of neutralizing antibody responses to sarbecoviruses

Authors: Janice Zhirong Jia, Chee Wah Tan, Samuel M S Cheng, Haogao Gu, Aileen Ying Yan Yeoh, Chris Ka Pun Mok, Yanqun Wang, Jincun Zhao, Nancy H L Leung, Benjamin J Cowling, Leo L M Poon, David S C Hui, Linfa Wang, Malik Peiris, Sophie A Valkenburg

Journal: Nat Commun

PubMed ID: 36271047

Doi: 10.1038/s41467-022-34038-6

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On the role of cell surface associated, mucin-like glycoproteins in the pennate diatom Craspedostauros australis (Bacillariophyceae)

Authors: Nicole Poulsen, Helene Hennig, Veikko F Geyer, Stefan Diez, Richard Wetherbee, Sorel Fitz-Gibbon, Matteo Pellegrini, Nils Kröger

Journal: J Phycol

PubMed ID: 36199194

Doi: 10.1111/jpy.13287

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Transient State Kinetics of Apicoplast DNA Polymerase Suggests the Involvement of Accessory Factors for Efficient and Accurate DNA Synthesis

Authors: Anamika Kumari, Anjali Yadav, Indrajit Lahiri

Journal: Biochemistry

PubMed ID: 36251801

Doi: 10.1021/acs.biochem.2c00446

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A critical path to producing high quality, reproducible data from quantitative western blot experiments

Authors: Sean C Taylor, Luciana K Rosselli-Murai, Bélinda Crobeddu, Isabelle Plante

Journal: Sci Rep

PubMed ID: 36266411

Doi: 10.1038/s41598-022-22294-x

Products & Services: Proteins, Expression, Isolation and Analysis

Protein kinase C beta relieves autism-like behavior in EN2 knockout mice via upregulation of the FTO/PGC-1α/UCP1 axis

Authors: Xingyu Song, Qibo Hu, Xiaoheng Xu, Wei Pan

Journal: J Biochem Mol Toxicol

PubMed ID: 36239013

Doi: 10.1002/jbt.23236

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Energy landscape reshaped by strain-specific mutations underlies epistasis in NS1 evolution of influenza A virus

Authors: Iktae Kim, Alyssa Dubrow, Bryan Zuniga, Baoyu Zhao, Noah Sherer, Abhishek Bastiray, Pingwei Li, Jae-Hyun Cho

Journal: Nat Commun

PubMed ID: 36182933

Doi: 10.1038/s41467-022-33554-9

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GITRL impairs the immunosuppressive function of MDSCs via PTEN-mediated signaling pathway in experimental Sjögren syndrome

Authors: Jie Tian, Beibei Zhang, Qingfang Yuan, Xueqing Sun, Na Peng, Bo Zhu, Chang Liu, Xiaoran Wang, Man Han, Meng Cao, Fan Xiao, Shengjun Wang, Ke Rui, Liwei Lu

Journal: Inflamm Res

PubMed ID: 36301339

Doi: 10.1007/s00011-022-01660-5

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Discovery and functional characterization of the oncogenicity and targetability of a novel gene fusion in pediatric angiosarcoma

Authors: Payal Jain, Sudarshan Iyer, Joshua Straka, Lea F Surrey, Jennifer Pogoriler, Harry Han, Tiffany Smith, Christine Busch, Elizabeth Fox, Marilyn Li, Angela J Waanders, Adam Resnick, Monika A Davare

Journal: Cold Spring Harb Mol Case Stud

PubMed ID: 36307212

Doi: 10.1101/mcs.a006222

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A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction

Authors: John T Happ, Corvin D Arveseth, Jessica Bruystens, Daniela Bertinetti, Isaac B Nelson, Cristina Olivieri, Jingyi Zhang, Danielle S Hedeen, Ju-Fen Zhu, Jacob L Capener, Jan W Bröckel, Lily Vu, C C King, Victor L Ruiz-Perez, Xuecai Ge, Gianluigi Veglia, Friedrich W Herberg, Susan S Taylor, Benjamin R Myers

Journal: Nat Struct Mol Biol

PubMed ID: 36202993

Doi: 10.1038/s41594-022-00838-z

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Evasion of cGAS and TRIM5 defines pandemic HIV

Authors: Lorena Zuliani-Alvarez, Morten L Govasli, Jane Rasaiyaah, Chris Monit, Stephen O Perry, Rebecca P Sumner, Simon McAlpine-Scott, Claire Dickson, K M Rifat Faysal, Laura Hilditch, Richard J Miles, Frederic Bibollet-Ruche, Beatrice H Hahn, Till Boecking, Nikos Pinotsis, Leo C James, David A Jacques, Greg J Towers

Journal: Nat Microbiol

PubMed ID: 36289397

Doi: 10.1038/s41564-022-01247-0

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Comparison of the kinetics and magnitude of antibody responses to different SARS-CoV-2 proteins in Sinopharm/BBIBP-CorV vaccinees following the BNT162b2 booster or natural infection

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Shashika Dayarathna, Thashmi Nimasha, Thushali Ranasinghe, Jeewantha Jayamali, Achala Kamaladasa, Maneshka Karunanada, Lahiru Perera, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: PLoS ONE

PubMed ID: 36227884

Doi: 10.1371/journal.pone.0274845

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Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination

Authors: Jia Xin Chua, Lindy Gillian Durrant, Yin Ling Chok, Oi Ming Lai

Journal: iScience

PubMed ID: 36277260

Doi: 10.1016/j.isci.2022.105379

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Cancer stem cell antigen nanodisc cocktail elicits anti-tumor immune responses in melanoma

Authors: Marisa E Aikins, You Qin, Hannah E Dobson, Alireza Hassani Najafabadi, Kexing Lyu, Yao Xu, Ying Xin, Anna Schwendeman, Max S Wicha, Alfred E Chang, Qiao Li, James J Moon

Journal: J Control Release

PubMed ID: 36206945

Doi: 10.1016/j.jconrel.2022.09.061

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Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library

Authors: Devan J Shell, Justin M Rectenwald, Peter H Buttery, Rebecca L Johnson, Caroline A Foley, Shiva K R Guduru, Mélanie Uguen, Juanita Sanchez Rubiano, Xindi Zhang, Fengling Li, Jacqueline L Norris-Drouin, Matthew Axtman, P Brian Hardy, Masoud Vedadi, Stephen V Frye, Lindsey I James, Kenneth H Pearce

Journal: SLAS Discov

PubMed ID: 36272689

Doi: 10.1016/j.slasd.2022.10.003

Products & Services: Recombinant Proteins

Sex Difference Leads to Differential Gene Expression Patterns and Therapeutic Efficacy in Mucopolysaccharidosis IVA Murine Model Receiving AAV8 Gene Therapy

Authors: Matthew Piechnik, Paige C Amendum, Kazuki Sawamoto, Molly Stapleton, Shaukat Khan, Nidhi Fnu, Victor Álvarez, Angelica Maria Herreño Pachon, Olivier Danos, Joseph T Bruder, Subha Karumuthil-Melethil, Shunji Tomatsu

Journal: Int J Mol Sci

PubMed ID: 36293546

Doi: 10.3390/ijms232012693

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External quality assessment of SARS-CoV-2 serology in European expert laboratories, April 2021

Authors: Ramona Mögling, Francesca Colavita, Johan Reimerink, Angeliki Melidou, Katrin Leitmeyer, Maria Keramarou, Daniele Lapa, Massimo Francalancia, Jean-Luc Murk, Ann Vossen, Fabrizio Carletti, Boris Hogema, Adam Meijer, Liesbet Deprez, Antonino di Caro, Concetta Castilletti, Chantal Bem Reusken

Journal: Euro Surveill

PubMed ID: 36268736

Doi: 10.2807/1560-7917.ES.2022.27.42.2101057

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Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity

Authors: Brett H Pogostin, Marina H Yu, Alon R Azares, Erin M Euliano, Cheuk Sun Edwin Lai, Gabriel Saenz, Samuel X Wu, Adam C Farsheed, Sarah M Melhorn, Tyler P Graf, Darren G Woodside, Jeffrey D Hartgerink, Kevin J McHugh

Journal: Biomater Sci

PubMed ID: 36102692

Doi: 10.1039/d2bm01242a

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation

Authors: Wen-Hsin Lee, Xiaorui Chen, I-Ju Liu, Jiin-Horng Lee, Chun-Mei Hu, Han-Chung Wu, Sheng-Kai Wang, Wen-Hwa Lee, Che Ma

Journal: Cell Rep

PubMed ID: 36288706

Doi: 10.1016/j.celrep.2022.111555

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Identification of human MHC-I HPV18 E6/E7-specific CD8 + T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice

Authors: Shiwen Peng, Deyin Xing, Louise Ferrall, Ya-Chea Tsai, Chien-Fu Hung, T-C Wu

Journal: J Biomed Sci

PubMed ID: 36224625

Doi: 10.1186/s12929-022-00864-5

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Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

Authors: Tilman L B Hölting, Florencia Cidre-Aranaz, Dana Matzek, Bastian Popper, Severin J Jacobi, Cornelius M Funk, Florian H Geyer, Jing Li, Ignazio Piseddu, Bruno L Cadilha, Stephan Ledderose, Jennifer Zwilling, Shunya Ohmura, David Anz, Annette Künkele, Frederick Klauschen, Thomas G P Grünewald, Maximilian M L Knott

Journal: Mol Cancer

PubMed ID: 36229873

Doi: 10.1186/s12943-022-01641-6

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Active Pharmaceutical Ingredient Uptake by Zebrafish (Danio rerio) Oct2 (slc22a2) Transporter Expressed in Xenopus laevis Oocytes

Authors: Elisabeth D Chang, Stewart F Owen, Christer Hogstrand, Nic R Bury

Journal: Environ Toxicol Chem

PubMed ID: 36102855

Doi: 10.1002/etc.5480

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Author Correction: Omicron BA4/BA5 escape neutralizing immunity elicited by BA1 infection

Authors: Khadija Khan, Farina Karim, Yashica Ganga, Mallory Bernstein, Zesuliwe Jule, Kajal Reedoy, Sandile Cele, Gila Lustig, Daniel Amoako, Nicole Wolter, Natasha Samsunder, Aida Sivro, James Emmanuel San, Jennifer Giandhari, Houriiyah Tegally, Sureshnee Pillay, Yeshnee Naidoo, Matilda Mazibuko, Yoliswa Miya, Nokuthula Ngcobo, Nithendra Manickchund, Nombulelo Magula, Quarraisha Abdool Karim, Anne von Gottberg, Salim S Abdool Karim, Willem Hanekom, Bernadett I Gosnell, Richard J Lessells, Tulio de Oliveira, Mahomed-Yunus S Moosa, Alex Sigal

Journal: Nat Commun

PubMed ID: 36229444

Doi: 10.1038/s41467-022-33371-0

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FAD-Deficient P187S mutation of NAD(P)H:quinone oxidoreductase 1 (NQO1*2) binds and accelerates β-amyloid aggregation

Authors: Sudipta Panja, David Siegel, Simonetta Camandola, Rafael de Cabo, David Ross, Krishna Mallela

Journal: Biosci Rep

PubMed ID: 36281795

Doi: 10.1042/BSR20220643

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MnO Nanozyme-Mediated CRISPR-Cas12a System for the Detection of SARS-CoV-2

Authors: Lina Wu, Xinjie Wang, Xiangchuan Wu, Shiqi Xu, Ming Liu, Xizhong Cao, Taishan Tang, Xingxu Huang, He Huang

Journal: ACS Appl Mater Interfaces

PubMed ID: 36301087

Doi: 10.1021/acsami.2c14497

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A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology

Authors: Benjamin F N Campbell, Antje Dittmann, Birgit Dreier, Andreas Plückthun, Shiva K Tyagarajan

Journal: Elife

PubMed ID: 36314779

Doi: 10.7554/eLife.80895

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Sequential Deletions of Interferon Inhibitors MGF110-9L and MGF505-7R Result in Sterile Immunity against the Eurasia Strain of Africa Swine Fever

Authors: Mingyang Ding, Wen Dang, Huanan Liu, Keshan Zhang, Fan Xu, Hong Tian, Huaguo Huang, Zhengwang Shi, Yongjie Sunkang, Xiaodong Qin, Yong Zhang, Haixue Zheng

Journal: J Virol

PubMed ID: 36197109

Doi: 10.1128/jvi.01192-22

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Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy

Authors: Evgenii N Tcyganov, Emilio Sanseviero, Douglas Marvel, Thomas Beer, Hsin-Yao Tang, Peter Hembach, David W Speicher, Qianfei Zhang, Laxminarasimha R Donthireddy, Ali Mostafa, Sabina Tsyganova, Vladimir Pisarev, Terri Laufer, Dmitriy Ignatov, Soldano Ferrone, Christiane Meyer, Hélène Maby-El Hajjami, Daniel E Speiser, Sooner Altiok, Scott Antonia, Xiaowei Xu, Wei Xu, Cathy Zheng, Lynn M Schuchter, Ravi K Amaravadi, Tara C Mitchell, Giorgos C Karakousis, Zhe Yuan, Luis J Montaner, Esteban Celis, Dmitry I Gabrilovich

Journal: Cancer Cell

PubMed ID: 36220073

Doi: 10.1016/j.ccell.2022.09.001

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Chitosan and chitosan oligosaccharide influence digestibility of whey protein isolate through electrostatic interaction

Authors: Linlin Wang, Lilong Wang, Chengrong Wen, Nan Wang, Chunhong Yan, Caihong Shen, Shuang Song

Journal: Int J Biol Macromol

PubMed ID: 36191784

Doi: 10.1016/j.ijbiomac.2022.09.258

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Characteristics of a new carotenoid cleavage dioxygenase NtCCD10 derived from Nicotiana tabacum

Authors: Fan Li, Xiaowei Gong, Yupeng Liang, Lijuan Peng, Xiulin Han, Mengliang Wen

Journal: Planta

PubMed ID: 36251100

Doi: 10.1007/s00425-022-04013-y

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Deciphering the Alphabet of Disorder-Glu and Asp Act Differently on Local but Not Global Properties

Authors: Mette Ahrensback Roesgaard, Jeppe E Lundsgaard, Estella A Newcombe, Nina L Jacobsen, Francesco Pesce, Emil E Tranchant, Søren Lindemose, Andreas Prestel, Rasmus Hartmann-Petersen, Kresten Lindorff-Larsen, Birthe B Kragelund

Journal: Biomolecules

PubMed ID: 36291634

Doi: 10.3390/biom12101426

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Outliers Matter-Correlation between S1 IgG SARS-CoV-2 Antibodies and Neutralizing SARS-CoV-2 Antibodies

Authors: Berthold Hocher, Anne Schönbrunn, Xin Chen, Bernhard K Krämer, Volker von Baehr

Journal: Microorganisms

PubMed ID: 36296343

Doi: 10.3390/microorganisms10102067

Neutralizing Antibody Responses Among Residents and Staff of Long-Term Care Facilities in the State of New Jersey During the First Wave of the COVID-19 Pandemic

Authors: Stephen M Friedman, Jieliang Li, Pauline Thomas, Manisha Gurumurthy, Richard Siderits, Anna Nepomich, Edward Lifshitz

Journal: J Community Health

PubMed ID: 36197535

Doi: 10.1007/s10900-022-01142-z

Insertion of circularly permuted cyan fluorescent protein into the ligand-binding domain of inositol 1,4,5-trisphosphate receptor for enhanced FRET upon binding of fluorescent ligand

Authors: Azmeree Jahan, Mst Tahmina Akter, Kiwamu Takemoto, Tai Oura, Akiko Shitara, Shingo Semba, Akihiro Nezu, Satoshi Suto, Takeharu Nagai, Akihiko Tanimura

Journal: Cell Calcium

PubMed ID: 36335765

Doi: 10.1016/j.ceca.2022.102668

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Long Noncoding RNA LINC00909 Induces Epithelial-Mesenchymal Transition and Contributes to Osteosarcoma Tumorigenesis and Metastasis

Authors: Wanshun Liu, Qi Zhang, Kai Shen, Keran Li, Jie Chang, He Li, Ao Duan, Sheng Zhang, Yumin Huang

Journal: J Oncol

PubMed ID: 36262353

Doi: 10.1155/2022/8660965

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Targeting SARS-CoV-2 infection through CAR-T-like bispecific T cell engagers incorporating ACE2

Authors: Mikail Dogan, Lina Kozhaya, Lindsey Placek, Fatih Karabacak, Mesut Yigit, Derya Unutmaz

Journal: Clin Transl Immunology

PubMed ID: 36285327

Doi: 10.1002/cti2.1421

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A non-canonical RNA-binding domain of the Fragile X protein, FMRP, elicits translational repression independent of mRNA G-quadruplexes

Authors: MaKenzie R Scarpitti, Julia E Warrick, Evelyn L Yoder, Michael G Kearse

Journal: J Biol Chem

PubMed ID: 36328245

Doi: 10.1016/j.jbc.2022.102660

Products & Services: Bacterial Expression

Genome-Wide Identification and Functional Analysis of the Gene Family Responding to Multiple Stressors in

Authors: Mei Zhang, Zhengfeng Wang, Shuguang Jian

Journal: Genes (Basel)

PubMed ID: 36360226

Doi: 10.3390/genes13111988

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The synergism of lytic polysaccharide monooxygenases with lichenase and their co-immobilization on silica nanospheres for green conversion of lichen biomass

Authors: Lixi Cai, Ying Zheng, Yunmeng Chu, Yuanqing Lin, Lixing Liu, Guangya Zhang

Journal: Front Nutr

PubMed ID: 36337671

Doi: 10.3389/fnut.2022.970540

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miR-124-3p Delivered Using Exosomes Attenuates the Keratinocyte Response to IL-17A Stimulation in Psoriasis

Authors: Simin Liu, Jian Gong

Journal: Oxid Med Cell Longev

PubMed ID: 36275890

Doi: 10.1155/2022/6264474

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Recent reconfiguration of an ancient developmental gene regulatory network in Heliocidaris sea urchins

Authors: Phillip L Davidson, Haobing Guo, Jane S Swart, Abdull J Massri, Allison Edgar, Lingyu Wang, Alejandro Berrio, Hannah R Devens, Demian Koop, Paula Cisternas, He Zhang, Yaolei Zhang, Maria Byrne, Guangyi Fan, Gregory A Wray

Journal: Nat Ecol Evol

PubMed ID: 36266460

Doi: 10.1038/s41559-022-01906-9

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Construction of a bioluminescence-based assay for bitter taste receptors (TAS2Rs)

Authors: Shi Min Tan, Wei-Guang Seetoh

Journal: Sci Rep

PubMed ID: 36271274

Doi: 10.1038/s41598-022-21678-3

Products & Services: Mammalian Expression

CRISPR/Cas Precisely Regulated DNA-Templated Silver Nanocluster Fluorescence Sensor for Meat Adulteration Detection

Authors: Jiahui Chen, Jianghua Liu, Di Wu, Ruiyuan Pan, Jian Chen, Yongning Wu, Mingquan Huang, Guoliang Li

Journal: J Agric Food Chem

PubMed ID: 36288511

Doi: 10.1021/acs.jafc.2c04500

Products & Services: Proteins, Expression, Isolation and Analysis

Autophagy Regulates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells Induced by Orthodontic Tension

Authors: Junyi Zheng, Bowen Xu, Kai Yang

Journal: Stem Cells Int

PubMed ID: 36248255

Doi: 10.1155/2022/2983862

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Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques

Authors: Pingchao Li, Qian Wang, Yizi He, Chenchen Yang, Zhengyuan Zhang, Zijian Liu, Bo Liu, Li Yin, Yilan Cui, Peiyu Hu, Yichu Liu, Pingqian Zheng, Wei Wang, Linbing Qu, Caijun Sun, Suhua Guan, Liqiang Feng, Ling Chen

Journal: Emerg Microbes Infect

PubMed ID: 36239345

Doi: 10.1080/22221751.2022.2136538

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Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H αβ tetramer

Authors: Abhinandan V Murthy, Ramita Sulu, Andrey Lebedev, Antti M Salo, Kati Korhonen, Rajaram Venkatesan, Hongmin Tu, Ulrich Bergmann, Janne Jänis, Mikko Laitaoja, Lloyd W Ruddock, Johanna Myllyharju, M Kristian Koski, Rik K Wierenga

Journal: J Biol Chem

PubMed ID: 36265586

Doi: 10.1016/j.jbc.2022.102614

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Bridging the gap between maleate hydratase, citraconase and isopropylmalate isomerase: Insights into the single broad-specific enzyme

Authors: Akila Thirumalai, Padmapriya Ganapathy Raman, Tamilselvan Jayavelu, Ramalingam Subramanian

Journal: Enzyme Microb Technol

PubMed ID: 36272242

Doi: 10.1016/j.enzmictec.2022.110140

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Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion

Authors: Palak N Patel, Thayne H Dickey, Christine S Hopp, Ababacar Diouf, Wai Kwan Tang, Carole A Long, Kazutoyo Miura, Peter D Crompton, Niraj H Tolia

Journal: Nat Commun

PubMed ID: 36202833

Doi: 10.1038/s41467-022-33336-3

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HCV Infection Increases the Expression of ACE2 Receptor, Leading to Enhanced Entry of Both HCV and SARS-CoV-2 into Hepatocytes and a Coinfection State

Authors: Tom Domovitz, Samer Ayoub, Michal Werbner, Joel Alter, Lee Izhaki Tavor, Yfat Yahalom-Ronen, Evgeny Tikhonov, Tomer Meirson, Yaakov Maman, Nir Paran, Tomer Israely, Moshe Dessau, Meital Gal-Tanamy

Journal: Microbiol Spectr

PubMed ID: 36314945

Doi: 10.1128/spectrum.01150-22

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Accelerated DNA vaccine regimen provides protection against Crimean-Congo hemorrhagic fever virus challenge in a macaque model

Authors: David W Hawman, Kimberly Meade-White, Shanna Leventhal, Sofia Appelberg, Gustaf Ahlén, Negin Nikouyan, Chad Clancy, Brian Smith, Patrick Hanley, Jamie Lovaglio, Ali Mirazimi, Matti Sällberg, Heinz Feldmann

Journal: Mol Ther

PubMed ID: 36184852

Doi: 10.1016/j.ymthe.2022.09.016

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Safety, efficacy, and DIVA feasibility on a novel live attenuated classical swine fever marker vaccine candidate

Authors: Chao Tong, Huanhuan Liu, Jiaying Wang, Yanyong Sun, Ning Chen

Journal: Vaccine

PubMed ID: 36328881

Doi: 10.1016/j.vaccine.2022.10.035

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Mannose and Hyaluronic Acid Dual-Modified Iron Oxide Enhances Neoantigen-Based Peptide Vaccine Therapy by Polarizing Tumor-Associated Macrophages

Authors: Ying Nie , Lu Shi , Yanan Zhang , Yunfei Guo , Hongchen Gu

Journal: Cancers

PubMed ID: 36291890

Doi: /10.3390/cancers14205107

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Structural basis of TRPV3 inhibition by an antagonist

Authors: Junping Fan, Linghan Hu, Zongwei Yue, Daohong Liao, Fusheng Guo, Han Ke, Daohua Jiang, Yong Yang, Xiaoguang Lei

Journal: Nat Chem Biol

PubMed ID: 36302896

Doi: 10.1038/s41589-022-01166-5

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Identifying a novel role for the master regulator Tal1 in the Endothelial to Hematopoietic Transition

Authors: Yasmin Natalia Serina Secanechia, Isabelle Bergiers, Matt Rogon, Christian Arnold, Nicolas Descostes, Stephanie Le, Natalia López-Anguita, Kerstin Ganter, Chrysi Kapsali, Lea Bouilleau, Aaron Gut, Auguste Uzuotaite, Ayshan Aliyeva, Judith B Zaugg, Christophe Lancrin

Journal: Sci Rep

PubMed ID: 36217016

Doi: 10.1038/s41598-022-20906-0

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Amphiphile-CpG vaccination induces potent lymph node activation and COVID-19 immunity in mice and non-human primates

Authors: Lochana M Seenappa, Aniela Jakubowski, Martin P Steinbuck, Erica Palmer, Christopher M Haqq, Crystal Carter, Jane Fontenot, Francois Villinger, Lisa K McNeil, Peter C DeMuth

Journal: npj Vaccines

PubMed ID: 36307453

Doi: 10.1038/s41541-022-00560-3

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Development of Enzymatic Depletion Methods for Preparation of Small Extracellular Vesicles with Long Blood-Circulation Half-Life

Authors: Yuki Kobayashi, Shimpei Kitamura, Yuki Takahashi, Yoshinobu Takakura

Journal: Pharm Res

PubMed ID: 36195822

Doi: 10.1007/s11095-022-03405-9

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Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP

Authors: Maria A Schumacher, Mirka E Wörmann, Max Henderson, Raul Salinas, Andreas Latoscha, Mahmoud M Al-Bassam, Kumar Siddharth Singh, Elaine Barclay, Katrin Gunka, Natalia Tschowri

Journal: Nat Commun

PubMed ID: 36192422

Doi: 10.1038/s41467-022-33537-w

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Engineering a precise adenine base editor with minimal bystander editing

Authors: Liang Chen, Shun Zhang, Niannian Xue, Mengjia Hong, Xiaohui Zhang, Dan Zhang, Jing Yang, Sijia Bai, Yifan Huang, Haowei Meng, Hao Wu, Changming Luan, Biyun Zhu, Gaomeng Ru, Hongyi Gao, Liping Zhong, Meizhen Liu, Mingyao Liu, Yiyun Cheng, Chengqi Yi, Liren Wang, Yongxiang Zhao, Gaojie Song, Dali Li

Journal: Nat Chem Biol

PubMed ID: 36229683

Doi: 10.1038/s41589-022-01163-8

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Expression changes of non-specific cytotoxic cell receptor (NCCRP1) and proliferation and migration of NCCs post-Nocardia seriolae infection in Northern Snakehead

Authors: Jian Teng, Meng Yao Cui, Yan Zhao, Hong Ju Chen, Wen Jing Du, Liang Yi Xue, Xiang Shan Ji

Journal: Dev Comp Immunol

PubMed ID: 36240859

Doi: 10.1016/j.dci.2022.104576

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miR-275/305 cluster is essential for maintaining energy metabolic homeostasis by the insulin signaling pathway in Bactrocera dorsalis

Authors: Junfei Xie, Hao Chen, Wenping Zheng, Zhaohui Cai, Xiaoxue Li, Hongyu Zhang

Journal: PLOS Genetics

Doi: 10.1371/journal.pgen.1010418

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TEMPOL inhibits SARS-CoV-2 replication and development of lung disease in the Syrian hamster model

Authors: Nunziata Maio, Sara Cherry, David C Schultz, Brett L Hurst, W Marston Linehan, Tracey A Rouault

Journal: iScience

PubMed ID: 36093377

Doi: 10.1016/j.isci.2022.105074

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Resistance of SARS-CoV-2 Omicron variant to convalescent and CoronaVac vaccine plasma

Authors: Yingdan Wang, Yunping Ma, Yan Xu, Jiangyan Liu, Xiang Li, Yuyuan Chen, Yan Chen, Jun Xie, Lianbo Xiao, Zheng Xiang, Fan Wu, Jinghe Huang

Journal: Emerg Microbes Infect

PubMed ID: 35001836

Doi: 10.1080/22221751.2022.2027219

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TNP Analogues Inhibit the Virulence Promoting IP3-4 Kinase Arg1 in the Fungal Pathogen Cryptococcus neoformans

Authors: Desmarini Desmarini, Daniel Truong, Lorna Wilkinson-White, Chandrika Desphande, Mario Torrado, Joel P Mackay, Jacqueline M Matthews, Tania C Sorrell, Sophie Lev, Philip E Thompson, Julianne Teresa Djordjevic

Journal: Biomolecules

PubMed ID: 36291735

Doi: 10.3390/biom12101526

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Glycoside hydrolase subfamily GH5_57 features a highly redesigned catalytic interface to process complex hetero-β-mannans

Authors: Marcele P Martins, Mariana A B Morais, Gabriela F Persinoti, Rafael H Galinari, Li Yu, Yoshihisa Yoshimi, Fernanda B Passos Nunes, Tatiani B Lima, Shayla F Barbieri, Joana L M Silveira, Vincent Lombard, Nicolas Terrapon, Paul Dupree, Bernard Henrissat, Mário T Murakami

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 36322419

Doi: 10.1107/S2059798322009561

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MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases

Authors: Zahra Mohtashami, Mithalesh K Singh, Nasim Salimiaghdam, Mustafa Ozgul, M Cristina Kenney

Journal: Int J Mol Sci

PubMed ID: 36233287

Doi: 10.3390/ijms231911991

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Velcrin-induced selective cleavage of tRNA(TAA) by SLFN12 causes cancer cell death

Authors: Sooncheol Lee, Stephanie Hoyt, Xiaoyun Wu, Colin Garvie, Joseph McGaunn, Mrinal Shekhar, Marcus Tötzl, Matthew G Rees, Andrew D Cherniack, Matthew Meyerson, Heidi Greulich

Journal: Nat Chem Biol

PubMed ID: 36302897

Doi: 10.1038/s41589-022-01170-9

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CD4-1 and CD8α T lymphocytes subsets in spotted sea bass (Lateolabrax maculatus) and comparison on antigenicity of T lymphocytes subsets in other three marine fish species

Authors: Xiaoyu Jiang, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan

Journal: Fish Shellfish Immunol

PubMed ID: 36210001

Doi: 10.1016/j.fsi.2022.10.004

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Loss of Chemerin in Rhabdomyosarcoma Cells Polarizes Adjacent Monocytes to an Immunosuppressive Phenotype

Authors: Rui Sun, Jia Le Lin, Man Si Cheng, Kang Yi Lee, Thilo Spruss, Christa Buechler, Herbert Schwarz

Journal: Biomedicines

PubMed ID: 36289872

Doi: 10.3390/biomedicines10102610

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Impairment of antiviral immune response and disruption of cellular functions by SARS-CoV-2 ORF7a and ORF7b

Authors: Tránsito García-García, Raúl Fernández-Rodríguez, Natalia Redondo, Ana de Lucas-Rius, Sara Zaldívar-López, Blanca Dies López-Ayllón, José M Suárez-Cárdenas, Ángeles Jiménez-Marín, María Montoya, Juan J Garrido

Journal: iScience

PubMed ID: 36310646

Doi: 10.1016/j.isci.2022.105444

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New mescaline-related N-acylhydrazone and its unsubstituted benzoyl derivative: Promising metallophores for copper-associated deleterious effects relief in Alzheimer's disease

Authors: Alessandra Carvalho, Barbara Marinho Barbosa, Jesica S Flores, Phelippe do Carmo Gonçalves, Renata Diniz, Yraima Cordeiro, Claudio O Fernández, Daphne S Cukierman, Nicolás A Rey

Journal: J Inorg Biochem

PubMed ID: 36396525

Doi: 10.1016/j.jinorgbio.2022.112033

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The potential effects and mechanisms of Gegen Qinlian Decoction in oxaliplatin-resistant colorectal cancer based on network pharmacology

Authors: Xiang Lin, Li Xu, Huicheng Tan, Xinyi Zhang, Huan Shao, Li Yao, Xuan Huang

Journal: Heliyon

PubMed ID: 36353164

Doi: 10.1016/j.heliyon.2022.e11305

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Modification of Hinge/Transmembrane and Signal Transduction Domains Improves the Expression and Signaling Threshold of GXMR-CAR Specific to spp

Authors: Matheus Henrique Dos Santos, Michele Procópio Machado, Pappanaicken R Kumaresan, Thiago Aparecido da Silva

Journal: Cells

PubMed ID: 36359781

Doi: 10.3390/cells11213386

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IFITM3 promotes NiV envelope protein-mediated entry into MDCK cells and interacts with the fusion subunit of the F protein

Authors: Wang Xu, Shou-Wen Du, Le-Tian Li, Xiao-Shuang Shi, Jia-Min Wang, Ti-Yuan Li, Ning-Yi Jin, Chang Li

Journal: Int J Biochem Cell Biol

PubMed ID: 36330888

Doi: 10.1016/j.biocel.2022.106325

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Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases

Authors: Gretchen L Seim, Steven V John, Nicholas L Arp, Zixiang Fang, David J Pagliarini, Jing Fan

Journal: Nat Chem Biol

PubMed ID: 36266351

Doi: 10.1038/s41589-022-01153-w

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CD8+ T cell clonotypes from prior SARS-CoV-2 infection predominate during the cellular immune response to mRNA vaccination

Authors: Emily S Ford, Koshlan Mayer-Blackwell, Lichen Jing, Anton M Sholukh, Russell St Germain, Emily L Bossard, Hong Xie, Thomas H Pulliam, Saumya Jani, Stacy Selke, Carlissa J Burrow, Christopher L McClurkan, Anna Wald, Michael R Holbrook, Brett Eaton, Elizabeth Eudy, Michael Murphy, Elena Postnikova, Harlan S Robins, Rebecca Elyanow, Rachel M Gittelman, Matyas Ecsedi, Elise Wilcox, Aude G Chapuis, Andrew Fiore-Gartland, David M Koelle

Journal: Res Sq

PubMed ID: 36263073

Doi: 10.21203/rs.3.rs-2146712/v1

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A bZIP transcription factor (CiFD) regulates drought and low temperature induced flowering by alternative splicing in citrus

Authors: Li-Xia Ye, Yan-Mei Wu, Jin-Xia Zhang, Jin-Xin Zhang, Huan Zhou, Ren-Fang Zeng, Wei-Xuan Zheng, Mei-Qi Qiu, Jing-Jing Zhou, Zong-Zhou Xie, Chun-Gen Hu, Jin-Zhi Zhang

Journal: J Integr Plant Biol

PubMed ID: 36250511

Doi: 10.1111/jipb.13390

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Epitope of antiphospholipid antibodies retrieved from peptide microarray based on R39-R43 of β2-glycoprotein I

Authors: Marc Moghbel, Aline Roth, Daniela Baptista, Kapka Miteva, Fabienne Burger, Fabrizio Montecucco, Nicolas Vuilleumier, François Mach, Karim J Brandt

Journal: Res Pract Thromb Haemost

PubMed ID: 36304483

Doi: 10.1002/rth2.12828

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Blocking Autophagy in M1 Macrophages Enhances Virus Replication and Eye Disease in Ocularly Infected Transgenic Mice

Authors: Ujjaldeep Jaggi, Harry H Matundan, Dhong Hyun Lee, Homayon Ghiasi

Journal: J Virol

PubMed ID: 36286481

Doi: 10.1128/jvi.01401-22

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Apigenin suppresses mycoplasma-induced alveolar macrophages necroptosis via enhancing the methylation of TNF-α promoter by PPARγ-Uhrf1 axis

Authors: Xiuzhen Mei, Jian Wang, Chao Zhang, Jiale Zhu, Beibei Liu, Qingyun Xie, Ting Yuan, Yuzi Wu, Rong Chen, Xing Xie, Yanna Wei, Li Wang, Guoqing Shao, Qiyan Xiong, Yefen Xu, Zhixin Feng, Zhenzhen Zhang

Journal: Phytomedicine

PubMed ID: 36332388

Doi: 10.1016/j.phymed.2022.154504

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Combining mass spectrometry and machine learning to discover bioactive peptides

Authors: Christian T Madsen, Jan C Refsgaard, Felix G Teufel, Sonny K Kjærulff, Zhe Wang, Guangjun Meng, Carsten Jessen, Petteri Heljo, Qunfeng Jiang, Xin Zhao, Bo Wu, Xueping Zhou, Yang Tang, Jacob F Jeppesen, Christian D Kelstrup, Stephen T Buckley, Søren Tullin, Jan Nygaard-Jensen, Xiaoli Chen, Fang Zhang, Jesper V Olsen, Dan Han, Mads Grønborg, Ulrik de Lichtenberg

Journal: Nat Commun

PubMed ID: 36266275

Doi: 10.1038/s41467-022-34031-z

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Functional EGF domain of the human neuregulin 1α produced in Escherichia coli with accurate disulfide bonds

Authors: Arthur Schveitzer Ferreira, Amanda Lopacinski, Michel Batista, Priscila Mazzocchi Hiraiwa, Natalia Fernanda Bueno, Beatriz Gomes Guimarães, Nilson I T Zanchin

Journal: Mol Biol Rep

PubMed ID: 36198848

Doi: 10.1007/s11033-022-07956-3

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The Antimicrobial Peptide LJ-hep2 from Exerting Activities against Multiple Pathogenic Bacteria and Immune Protection In Vivo

Authors: Ruihao Gong, Zhe An, Weibin Zhang, Fangyi Chen, Ke-Jian Wang

Journal: Mar Drugs

PubMed ID: 36286474

Doi: 10.3390/md20100651

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Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation

Authors: Yoshibumi Ueda, Yuri Miura, Nario Tomishige, Naotoshi Sugimoto, Megumi Murase, Genki Kawamura, Norihiko Sasaki, Toshiyuki Ishiwata, Takeaki Ozawa

Journal: Cell Chem Biol

PubMed ID: 36288730

Doi: 10.1016/j.chembiol.2022.10.002

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Inhibition of intermittent calcium-activated potassium channel (SK4) attenuates Ang II-induced hypertrophy of human-induced stem cell-derived cardiomyocytes via targeting Ras-Raf-MEK1/2-ERK1/2 and CN-NFAT signaling pathways

Authors: Hongyi Zhao, Xi Wang, Yanhong Tang, Qingyan Zhao, Congxin Huang

Journal: Cell Biol Int

PubMed ID: 36273427

Doi: 10.1002/cbin.11948

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Engineering Self-Assembled Endolysin Nanoparticles against Antibiotic-Resistant Bacteria

Authors: Christian K O Dzuvor, Bhuvana K Shanbhag, Tayyaba Younas, Hsin-Hui Shen, Victoria S Haritos, Lizhong He

Journal: ACS Appl Bio Mater

PubMed ID: 36194892

Doi: 10.1021/acsabm.2c00741

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