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A human adenovirus encoding IFN-γ can transduce Tasmanian devil facial tumour cells and upregulate MHC-I

Authors: Ahab N Kayigwe, Jocelyn M Darby, A Bruce Lyons, Amanda L Patchett, Leszek Lisowski, Guei-Sheung Liu, Andrew S Flies

Journal: J Gen Virol

PubMed ID: 36382885

Doi: 10.1099/jgv.0.001812

Products & Services: Recombinant Antibody Expression

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies

Authors: Nadeem Murtaza, Annie A Cheng, Chad O Brown, Durga Praveen Meka, Shuai Hong, Jarryll A Uy, Joelle El-Hajjar, Neta Pipko, Brianna K Unda, Birgit Schwanke, Sansi Xing, Bhooma Thiruvahindrapuram, Worrawat Engchuan, Brett Trost, Eric Deneault, Froylan Calderon de Anda, Bradley W Doble, James Ellis, Evdokia Anagnostou, Gary D Bader, Stephen W Scherer, Yu Lu, Karun K Singh

Journal: Cell Rep

PubMed ID: 36417873

Doi: 10.1016/j.celrep.2022.111678

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TMT-Based Comparative Peptidomics Analysis of Rice Seedlings under Salt Stress: An Accessible Method to Explore Plant Stress-Tolerance Processing

Authors: Wanlu Ma, Chenchen Zhang, Wei Zhang, Pijie Sheng, Minyan Xu, Ying Ni, Meng Chen, Beijiu Cheng, Xin Zhang

Journal: J Proteome Res

PubMed ID: 36351196

Doi: 10.1021/acs.jproteome.2c00318

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Novel Antibody Exerts Antitumor Effect through Downregulation of CD147 and Activation of Multiple Stress Signals

Authors: Keisuke Fukuchi, Kayoko Nanai, Hiroshi Yuita, Chikako Maru, Jun Tsukada, Masato Ishigami, Yoko Nagai, Yoko Nakano, Chigusa Yoshimura, Kozo Yoneda, Masato Amano, Kensuke Nakamura, Yoko Oda, Haruyuki Nishigohri, Shoji Yamamoto, Yusuke Ohnishi-Totoki, Koichiro Inaki, Hironobu Komori, Rika Nakano, Yoshiyuki Kanari, Atsuko Nishida, Yumi Matsui, Satoko Funo, Sayako Takahashi, Toshiaki Ohtsuka, Toshinori Agatsuma

Journal: J Oncol

PubMed ID: 36385956

Doi: 10.1155/2022/3552793

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Recombinant Vaccinia Virus Expressing Apical Membrane Antigen 1 or Microneme Protein Enhances Protection against Infection in Mice

Authors: Min-Ju Kim, Ki-Back Chu, Su-Hwa Lee, Hae-Ji Kang, Keon-Woong Yoon, Md Atique Ahmed, Fu-Shi Quan

Journal: Trop Med Infect Dis

PubMed ID: 36355892

Doi: 10.3390/tropicalmed7110350

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Accelerated Polyethylene Terephthalate (PET) Enzymatic Degradation by Room Temperature Alkali Pre-treatment for Reduced Polymer Crystallinity

Authors: Sariah Giraldo-Narcizo, Nihal Guenani, Ana María Sánchez-Pérez, Antonio Guerrero

Journal: Chembiochem

PubMed ID: 36341520

Doi: 10.1002/cbic.202200503

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Intrinsically Unstructured Sequences in the mRNA 3' UTR Reduce the Ability of Poly(A) Tail to Enhance Translation

Authors: Wan-Jung C Lai, Mingyi Zhu, Margarita Belinite, Gregory Ballard, David H Mathews, Dmitri N Ermolenko

Journal: J Mol Biol

PubMed ID: 36368412

Doi: 10.1016/j.jmb.2022.167877

Products & Services: Recombinant Antibody Expression

Multivalent binding of the hub protein LC8 at a newly discovered site in 53BP1

Authors: Jesse Howe, Austin Weeks, Patrick Reardon, Elisar Barbar

Journal: Biophys J

PubMed ID: 36335430

Doi: 10.1016/j.bpj.2022.11.006

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Plant-Produced S1 Subunit Protein of SARS-CoV-2 Elicits Immunogenic Responses in Mice

Authors: Chalisa Panapitakkul, Narach Khorattanakulchai, Kaewta Rattanapisit, Theerakarn Srisangsung, Balamurugan Shanmugaraj, Supranee Buranapraditkun, Chutitorn Ketloy, Eakachai Prompetchara, Waranyoo Phoolcharoen

Journal: Vaccines (Basel)

PubMed ID: 36423056

Doi: 10.3390/vaccines10111961

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COPA A-to-I RNA editing hijacks endoplasmic reticulum stress to promote metastasis in colorectal cancer

Authors: Shu-Yang Wang, Ling-Jie Zhang, Guo-Jun Chen, Qi-Qi Ni, Yuan Huang, Dan Zhang, Fang-Yi Han, Wen-Feng He, Li-Ling He, Yan-Qing Ding, Hong-Li Jiao, Ya-Ping Ye

Journal: Cancer Lett

PubMed ID: 36336148

Doi: 10.1016/j.canlet.2022.215995

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Health safety of parabens evaluated by selected in vitro methods

Authors: L Svobodova, K Kejlova, M Rucki, J Chrz, P Kubincova, M Dvorakova, H Kolarova, D Jirova

Journal: Regul Toxicol Pharmacol

PubMed ID: 36455707

Doi: 10.1016/j.yrtph.2022.105307

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Production of cytoplasmic type citrus leprosis virus-like particles by plant molecular farming

Authors: Oscar A Ortega-Rivera, Veronique Beiss, Elizabeth O Osota, Soo Khim Chan, Sweta Karan, Nicole F Steinmetz

Journal: Virology

PubMed ID: 36434906

Doi: 10.1016/j.virol.2022.11.004

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Recovery of Siniperca chuatsi rhabdovirus from cloned cDNA

Authors: Xiaoyu Liu, Xiaodong Zhang, Zhendong Xu, Zhiyang Huang, Junyao Zhong, Yinzhi Zhu, Yongwei Wei

Journal: J Fish Dis

PubMed ID: 36321410

Doi: 10.1111/jfd.13726

Products & Services: Molecular Biology Reagents

High anti-SARS-CoV-2 seroprevalence among unvaccinated mother-child pairs from a rural setting in north-eastern Tanzania during the second wave of COVID-19

Authors: Omari Abdul Msemo, Laura Pérez-Alós, Daniel T R Minja, Cecilie Bo Hansen, Samwel Gesase, George Mtove, Joyce Mbwana, Victoria Marie Linderod Larsen, Emilie Caroline Skuladottir Bøgestad, Louise Groth Grunnet, Dirk Lund Christensen, Ib Christian Bygbjerg, David Burgner, Christentze Schmiegelow, Peter Garred, Line Hjort

Journal: IJID Reg

PubMed ID: 36466214

Doi: 10.1016/j.ijregi.2022.11.011

Products & Services: Proteins, Expression, Isolation and Analysis

Endotoxin-free gram-negative bacterium as a system for production and secretion of recombinant proteins

Authors: Ehud Shahar, Ken Emquies, Itai Bloch, Dalia Eliahu, Ran Ben Adiva, Jacob Pitcovski, Itamar Yadid

Journal: Appl Microbiol Biotechnol

PubMed ID: 36445389

Doi: 10.1007/s00253-022-12295-1

Products & Services: Proteins, Expression, Isolation and Analysis

In silico design, production and immunization evaluation of a recombinant bivalent fusion protein candidate vaccine against E coli O157:H7

Authors: Hossein Samiei, Shahram Nazarian, Abass Hajizade, Emad Kordbacheh

Journal: Int Immunopharmacol

PubMed ID: 36450206

Doi: 10.1016/j.intimp.2022.109464

Products & Services: Proteins, Expression, Isolation and Analysis

An insecticide target in mechanoreceptor neurons

Authors: Xiaomu Qiao , Xiaoyu Zhang , Zhendong Zhou , Lei Guo , Weiping Wu , Suhan Ma , Xinzhong Zhang , Craig Montell , Jia Huang

Journal: Sci Adv

PubMed ID: 36417522

Doi: 10.1126/sciadv.abq3132

Products & Services: Gene Synthesis Proteins, Expression, Isolation and Analysis Polyclonal Antibody Services

DNA topology regulates PAM-Cas9 interaction and DNA unwinding to enable near-PAMless cleavage by thermophilic Cas9

Authors: Ya-Jing Shi , Min Duan , Jun-Mei Ding , Fan-Qi Wang , Li-Li Bi , Cai-Xiang Zhang , Yi-Zhou Zhang , Jun-Yi Duan , An-Hui Huang , Xin-Lin Lei , Hao Yin , Ying Zhang

Journal: Mol Cell

PubMed ID: 36272409

Doi: 10.1016/j.molcel.2022.09.032

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Rearranged endogenized plant pararetroviruses as evidence of heritable RNA-based immunity

Authors: Adrian A Valli, Irene Gonzalo-Magro, Diego H Sanchez

Journal: Mol Biol Evol

PubMed ID: 36322467

Doi: 10.1093/molbev/msac240

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Activation of a novel αAR-spinophilin-cofilin axis determines the effect of α adrenergic drugs on fear memory reconsolidation

Authors: Shalini Saggu, Yunjia Chen, Christopher Cottingham, Hasibur Rehman, Hongxia Wang, Sixue Zhang, Corinne Augelli-Szafran, Sumin Lu, Nevin Lambert, Kai Jiao, Xin-Yun Lu, Qin Wang

Journal: Mol Psychiatry

PubMed ID: 36357671

Doi: 10.1038/s41380-022-01851-w

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Ornate, large, extremophilic (OLE) RNA forms a kink turn necessary for OapC protein recognition and RNA function

Authors: Seth E Lyon, Kimberly A Harris, Nicole B Odzer, Sarah G Wilkins, Ronald R Breaker

Journal: J Biol Chem

PubMed ID: 36336078

Doi: 10.1016/j.jbc.2022.102674

Products & Services: PCR Cloning and Subcloning

FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis

Authors: Allison V Mitchell, Ling Wu, C James Block, Mu Zhang, Justin Hackett, Douglas B Craig, Wei Chen, Yongzhong Zhao, Bin Zhang, Yongjun Dang, Xiaohong Zhang, Shengping Zhang, Chuangui Wang, Heather Gibson, Lori A Pile, Benjamin Kidder, Larry Matherly, Zhe Yang, Yali Dou, Guojun Wu

Journal: Nat Commun

PubMed ID: 36319643

Doi: 10.1038/s41467-022-34239-z

Products & Services: Plasmid DNA Preparation

Antibody-mediated delivery of CRISPR-Cas9 ribonucleoproteins in human cells

Authors: Stephanie Ubiparipovic, Daniel Christ, Romain Rouet

Journal: Protein Eng Des Sel

PubMed ID: 36336952

Doi: 10.1093/protein/gzac011

Products & Services: Gene Synthesis

The Immunological Epigenetic Landscape of the Human Life Trajectory

Authors: Iva Juříčková, Michael Hudec, Felix Votava, Jan Vosáhlo, Saak Victor Ovsepian, Marie Černá, Valerie Bríd O'Leary

Journal: Biomedicines

PubMed ID: 36428462

Doi: 10.3390/biomedicines10112894

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Evolutionary gain and loss of a plant pattern-recognition receptor for HAMP recognition

Authors: Simon Snoeck, Bradley W Abramson, Anthony G K Garcia, Ashley N Egan, Todd P Michael, Adam Steinbrenner

Journal: Elife

PubMed ID: 36377784

Doi: 10.7554/eLife.81050

Products & Services: Peptide Synthesis

Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2

Authors: Ren-Lei Ji, Shan-Shan Jiang, Ya-Xiong Tao

Journal: Biomolecules

PubMed ID: 36358958

Doi: 10.3390/biom12111608

Products & Services: PCR Cloning and Subcloning

Functional and molecular dissection of HCMV long non-coding RNAs

Authors: Sungwon Lee, Hyewon Kim, Ari Hong, Jaewon Song, Sungyul Lee, Myeonghwan Kim, Sung-Yeon Hwang, Dongjoon Jeong, Jeesoo Kim, Ahyeon Son, Young-Suk Lee, V Narry Kim, Jong-Seo Kim, Hyeshik Chang, Kwangseog Ahn

Journal: Sci Rep

PubMed ID: 36369338

Doi: 10.1038/s41598-022-23317-3

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ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation

Authors: Alexander R van Vliet, George N Chiduza, Sarah L Maslen, Valerie E Pye, Dhira Joshi, Stefano De Tito, Harold B J Jefferies, Evangelos Christodoulou, Chloë Roustan, Emma Punch, Javier H Hervás, Nicola O'Reilly, J Mark Skehel, Peter Cherepanov, Sharon A Tooze

Journal: Mol Cell

PubMed ID: 36347259

Doi: 10.1016/j.molcel.2022.10.017

Products & Services: Proteins, Expression, Isolation and Analysis

KCNQ1OT1 sponges miR-34a to promote malignant progression of malignant melanoma via upregulation of the STAT3/PD-L1 axis

Authors: Xin Wang, Zhiyao Ren, Yunfeng Xu, Xiang Gao, Hainian Huang, Fei Zhu

Journal: Environ Toxicol

PubMed ID: 36399467

Doi: 10.1002/tox.23687

Products & Services: Proteins, Expression, Isolation and Analysis

Epsilon-caprolactone-modified polyethylenimine as a genetic vehicle for stem cell-based bispecific antibody and exosome synergistic therapy

Authors: Yan Tan, Jiali Cai, Zhiyong Wang

Journal: Regen Biomater

PubMed ID: 36683744

Doi: 10.1093/rb/rbac090

Products & Services: Proteins, Expression, Isolation and Analysis

Immune Phenotypes and Target Antigens of Clonally Expanded Bone Marrow T Cells in Treatment-Naïve Multiple Myeloma

Authors: Carlotta Welters, María Fernanda Lammoglia Cobo, Christian Alexander Stein, Meng-Tung Hsu, Amin Ben Hamza, Livius Penter, Xiaojing Chen, Christopher Buccitelli, Oliver Popp, Philipp Mertins, Kerstin Dietze, Lars Bullinger, Andreas Moosmann, Eric Blanc, Dieter Beule, Armin Gerbitz, Julian Strobel, Holger Hackstein, Hans-Peter Rahn, Klaus Dornmair, Thomas Blankenstein, Leo Hansmann

Journal: Cancer Immunol Res

PubMed ID: 36122410

Doi: 10.1158/2326-6066.CIR-22-0434

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Biochemical Identification of a Nuclear Coactivator Protein Required for AtrR-Dependent Gene Regulation in Aspergillus fumigatus

Authors: Sanjoy Paul, Shivani Ror, W Hayes McDonald, W Scott Moye-Rowley

Journal: mSphere

PubMed ID: 36374043

Doi: 10.1128/msphere.00476-22

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A novel humanized Chi3l1 blocking antibody attenuates acetaminophen-induced liver injury in mice

Authors: Leike Li, Yankai Wen, Daniel Wrapp, Jongmin Jeong, Peng Zhao, Wei Xiong, Constance Lynn Atkins, Zhao Shan, Deng Hui, Jason S McLellan, Ningyan Zhang, Cynthia Ju, Zhiqiang An

Journal: Antib Ther

PubMed ID: 36683763

Doi: 10.1093/abt/tbac027

Products & Services: Proteins, Expression, Isolation and Analysis

An odorant receptor that senses four classes of musk compounds

Authors: Keiichi Yoshikawa, Jun Deguchi, Hu Jieying, Hsiu-Yi Lu, Hiroaki Matsunami

Journal: Curr Biol

PubMed ID: 36370695

Doi: 10.1016/j.cub.2022.10.038

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The Integration of Proteome-Wide PTM Data with Protein Structural and Sequence Features Identifies Phosphorylations that Mediate 14-3-3 Interactions

Authors: C M Egbert, L R Warr, K L Pennington, M M Thornton, A J Vaughan, S W Ashworth, M J Heaton, N English, M P Torres, J L Andersen

Journal: J Mol Biol

PubMed ID: 36402225

Doi: 10.1016/j.jmb.2022.167890

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Human histone pre-mRNA assembles histone or canonical mRNA-processing complexes by overlapping 3'-end sequence elements

Authors: Francesco S Ielasi, Sara Ternifi, Emeline Fontaine, Domenico Iuso, Yohann Couté, Andrés Palencia

Journal: Nucleic Acids Res

PubMed ID: 36447390

Doi: 10.1093/nar/gkac878

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Chitosan-functionalized graphene oxide as adjuvant in HEV P239 vaccine

Authors: Qianyu Bai, Zhiwen Wang, Yina An, Jijing Tian, Zhilin Li, Yifei Yang, Yanjun Dong, Mingyong Chen, Tianlong Liu

Journal: Vaccine

PubMed ID: 36371365

Doi: 10.1016/j.vaccine.2022.11.005

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Recent progress in adaptive laboratory evolution of industrial microorganisms

Authors: Guanglu Wang, Qian Li, Zhan Zhang, Xianzhong Yin, Bingyang Wang, Xuepeng Yang

Journal: J Ind Microbiol Biotechnol

PubMed ID: 36323428

Doi: 10.1093/jimb/kuac023

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A KLHL40 3' UTR splice-altering variant causes milder NEM8, an under-appreciated disease mechanism

Authors: Lein N H Dofash, Gavin V Monahan, Emilia Servián-Morilla, Eloy Rivas, Fathimath Faiz, Patricia Sullivan, Emily Oates, Joshua Clayton, Rhonda L Taylor, Mark R Davis, Traude Beilharz, Nigel G Laing, Macarena Cabrera-Serrano, Gianina Ravenscroft

Journal: Hum Mol Genet

PubMed ID: 36322148

Doi: 10.1093/hmg/ddac272

Products & Services: Mammalian Expression

Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signaling

Authors: Dennis Dik-Long Chau, Wen Li, Wai Wa Ray Chan, Jacquelyne Ka-Li Sun, Yuqi Zhai, Hei-Man Chow, Kwok-Fai Lau

Journal: FASEB J

PubMed ID: 36250347

Doi: 10.1096/fj.202200757R

Products & Services: Proteins, Expression, Isolation and Analysis

Retinal regions shape human and murine Müller cell proteome profile and functionality

Authors: Lew Kaplan, Corinne Drexler, Anna M Pfaller, Santra Brenna, Kirsten A Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M Hauck, Antje Grosche

Journal: Glia

PubMed ID: 36334068

Doi: 10.1002/glia.24283

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Trifluoro-icaritin ameliorates spared nerve injury-induced neuropathic pain by inhibiting microglial activation through α7nAChR-mediated blockade of BDNF/TrkB/KCC2 signaling in the spinal cord of rats

Authors: Dandan Jia, Guangsen Liu, Yalan Sun, Zhiping Hu, Zhihua Huang, Cheng Huang

Journal: Biomed Pharmacother

PubMed ID: 36375307

Doi: 10.1016/j.biopha.2022.114001

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Comprehensive profiling of the human viral exposome in households containing an at-risk child with mitochondrial disease during the 2020-2021 COVID-19 pandemic

Authors: Eliza M Gordon-Lipkin, Christopher S Marcum, Shannon Kruk, Elizabeth Thompson, Sophie E M Kelly, Heather Kalish, Lorenza Bellusci, Surender Khurana, Kaitlyn Sadtler, Peter J McGuire

Journal: Clin Transl Med

PubMed ID: 36336785

Doi: 10.1002/ctm2.1100

Products & Services: Mammalian Expression

Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway

Authors: Yuyuan Yao, Zhichu Ren, Ruihan Yang, Yilan Mei, Yuying Dai, Qian Cheng, Chong Xu, Xiaogang Xu, Sanying Wang, Kyoung Mi Kim, Ji Heon Noh, Jian Zhu, Ningwei Zhao, Yong U Liu, Genxiang Mao, Jian Sima

Journal: Cell Biosci

PubMed ID: 36333711

Doi: 10.1186/s13578-022-00918-z

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Grafting of short elastin-like peptides using an electric field

Authors: Nuttanit Pramounmat, Sogol Asaei, Jacob D Hostert, Kathleen Young, Horst A von Recum, Julie N Renner

Journal: Sci Rep

PubMed ID: 36333395

Doi: 10.1038/s41598-022-21672-9

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How modular protein nanoparticles may expand the ability of subunit anti-viral vaccines: The spring viremia carp virus (SVCV) case

Authors: Mauricio Rojas, Patricia Aceituno, Maria E Salvador, Marlid Garcia-Ordoñez, Mariana Teles, Maria Del Mar Ortega-Villaizan, Luis Perez, Nerea Roher

Journal: Fish Shellfish Immunol

PubMed ID: 36371050

Doi: 10.1016/j.fsi.2022.10.067

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Alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models

Authors: Thomas Caracena, Rachel Blomberg, Rukshika S Hewawasam, Zoe E Fry, David W H Riches, Chelsea M Magin

Journal: Biomater Sci

PubMed ID: 36366982

Doi: 10.1039/d2bm00827k

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speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing

Authors: Rocío Castellanos-Rueda, Raphaël B Di Roberto, Florian Bieberich, Fabrice S Schlatter, Darya Palianina, Oanh T P Nguyen, Edo Kapetanovic, Heinz Läubli, Andreas Hierlemann, Nina Khanna, Sai T Reddy

Journal: Nat Commun

PubMed ID: 36323661

Doi: 10.1038/s41467-022-34141-8

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Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses

Authors: Ruyu Wang, Guanglei Zhai, Guanghao Zhu, Mengge Wang, Xiaoyi Gong, Weidong Zhang, Guangbo Ge, Hongzhuan Chen, Lili Chen

Journal: Bioorg Chem

PubMed ID: 36395603

Doi: 10.1016/j.bioorg.2022.106264

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Mammalian Target of Rapamycin Inhibition Decreases Angiotensin II-Induced Steroidogenesis in HAC15 Human Adrenocortical Carcinoma Cells

Authors: Yusuf Ali, Elise P Gomez-Sanchez, Celso E Gomez-Sanchez

Journal: Endocrinology

PubMed ID: 36320101

Doi: 10.1210/endocr/bqac185

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Broad-specificity indirect competitive enzyme-linked immunosorbent assay for aristolochic acids: Computer-aided hapten design and molecular mechanism of antibody recognition

Authors: Xiaonan Wang, Qingpeng Lu, Leina Dou, Minggang Liu, Peipei Li, Wenbo Yu, Xuezhi Yu, Zhanhui Wang, Kai Wen

Journal: Sci Total Environ

PubMed ID: 36347294

Doi: 10.1016/j.scitotenv.2022.159941

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New Effective Method of Lactococcus Genome Editing Using Guide RNA-Directed Transposition

Authors: Pavel Yu Pechenov, Danil A Garagulya, Daniil S Stanovov, Andrey V Letarov

Journal: Int J Mol Sci

PubMed ID: 36430465

Doi: 10.3390/ijms232213978

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Linoleic acid binds to SARS-CoV-2 RdRp and represses replication of seasonal human coronavirus OC43

Authors: Anna Goc, Waldemar Sumera, Matthias Rath, Aleksandra Niedzwiecki

Journal: Sci Rep

PubMed ID: 36352079

Doi: 10.1038/s41598-022-23880-9

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Alginate-Chitosan Hydrogel Formulations Sustain Baculovirus Delivery and VEGFA Expression Which Promotes Angiogenesis for Wound Dressing Applications

Authors: Sabrina Schaly, Paromita Islam, Ahmed Abosalha, Jacqueline L Boyajian, Dominique Shum-Tim, Satya Prakash

Journal: Pharmaceuticals (Basel)

PubMed ID: 36355553

Doi: 10.3390/ph15111382

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PNGase H + variant from Rudaea cellulosilytica with improved deglycosylation efficiency for rapid analysis of eukaryotic N-glycans and hydrogen deuterium exchange mass spectrometry analysis of glycoproteins

Authors: Rui-Rui Guo, Tian-Chan Zhang, Thomas Ole Tandrup Lambert, Ting Wang, Josef Voglmeir, Kasper D Rand, Li Liu

Journal: Rapid Commun Mass Spectrom

PubMed ID: 35945033

Doi: 10.1002/rcm.9376

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The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice

Authors: Karianne Fjeld, Anny Gravdal, Ranveig S Brekke, Jahedul Alam, Steven J Wilhelm, Khadija El Jellas, Helene N Pettersen, Jianguo Lin, Marie H Solheim, Solrun J Steine, Bente B Johansson, Pål R Njølstad, Caroline S Verbeke, Xunjun Xiao, Mark E Lowe, Anders Molven

Journal: Pancreatology

PubMed ID: 36379850

Doi: 10.1016/j.pan.2022.11.003

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Immune responses of hemocytes in the blood clam Tegillarca granosa in response to in vivo Vibrio harveyi infection

Authors: Qianyuan Yang, Guoqiang Xiao, Ran Chen, Xiaolin Huang, Shuangshuang Teng

Journal: Fish Shellfish Immunol

PubMed ID: 36435369

Doi: 10.1016/j.fsi.2022.11.035

Products & Services: Proteins, Expression, Isolation and Analysis

Seroepidemiological and genomic investigation of SARS-CoV-2 spread in North East region of India

Authors: Romi Wahengbam, Pankaj Bharali, Prasenjit Manna, Tridip Phukan, Moirangthem Goutam Singh, Gayatri Gogoi, Yasmin Begam Tapadar, Anil Kumar Singh, Rituraj Konwar, Channakeshavaiah Chikkaputtaiah, Natarajan Velmurugan, Selvaraman Nagamani, Hridoy Jyoti Mahanta, Himakshi Sarma, Ravi Kumar Sahu, Prachurjya Dutta, Sawlang Borsingh Wann, Jatin Kalita, G Narahari Sastry

Journal: Indian J Med Microbiol

PubMed ID: 36371334

Doi: 10.1016/j.ijmmb.2022.10.011

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SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1

Authors: Di Wang, Weiwei Liang, Di Huo, Hongyong Wang, Ying Wang, Chaohua Cong, Chunting Zhang, Shi Yan, Ming Gao, Xiaoli Su, Xingli Tan, Wenmo Zhang, Ling Han, Dongmei Zhang, Honglin Feng

Journal: Cell Death Differ

PubMed ID: 36443440

Doi: 10.1038/s41418-022-01089-7

Products & Services: Proteins, Expression, Isolation and Analysis

PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1

Authors: Yuzhong Chen, Wanqing Liang, Jun Du, Jiachi Ma, Rongrui Liang, Min Tao

Journal: Exp Cell Res

PubMed ID: 36400182

Doi: 10.1016/j.yexcr.2022.113413

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TMBIM5 is the Ca /H antiporter of mammalian mitochondria

Authors: Shane Austin, Ronald Mekis, Sami E M Mohammed, Mariafrancesca Scalise, Wen-An Wang, Michele Galluccio, Christina Pfeiffer, Tamara Borovec, Katja Parapatics, Dijana Vitko, Nora Dinhopl, Nicolas Demaurex, Keiryn L Bennett, Cesare Indiveri, Karin Nowikovsky

Journal: EMBO Rep

PubMed ID: 36321428

Doi: 10.15252/embr.202254978

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Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections

Authors: Catherine B Blackwood, Margalida Mateu-Borrás, Emel Sen-Kilic, Gage M Pyles, Sarah Jo Miller, Kelly L Weaver, William T Witt, Annalisa B Huckaby, Jason Kang, Courtney E Chandler, Robert K Ernst, F Heath Damron, Mariette Barbier

Journal: npj Vaccines

PubMed ID: 36357402

Doi: 10.1038/s41541-022-00562-1

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Heat shock protein 20 suppresses breast carcinogenesis by inhibiting the MAPK and AKT signaling pathways

Authors: Yinxi Yang, Yifeng Wu, Lihong Hou, Xin Ge, Guoquan Song, Hongdou Jin

Journal: Oncol Lett

PubMed ID: 36380873

Doi: 10.3892/ol.2022.13582

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Prevalence of Neospora caninum, Toxoplasma gondii and Brucella abortus in water buffalo (Bubalus bubalis): Climatic and environmental risk factors in eastern and southeast Mexico

Authors: J Baltazar-Pérez, F Utrera-Quintana, J Camacho-Ronquillo, R González-Garduño, H Jiménez-Cortez, A Villa-Mancera

Journal: Microb Pathog

PubMed ID: 36356791

Doi: 10.1016/j.micpath.2022.105871

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In silico analysis of a novel protein in CAR T- cell therapy for the treatment of hematologic cancer through molecular modelling, docking, and dynamics approach

Authors: Rimjhim Mohanty, Manoswini Manoswini, Ajit Kumar Dhal, Niladri Ganguly

Journal: Comput Biol Med

PubMed ID: 36395593

Doi: 10.1016/j.compbiomed.2022.106285

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The role of carbonic anhydrase-mediated tissue oxygen extraction in a marine teleost acclimated to hypoxia

Authors: Angelina M Dichiera, Benjamin Negrete, Kerri Lynn Ackerly, Andrew J Esbaugh

Journal: J Exp Biol

PubMed ID: 36354111

Doi: 10.1242/jeb.244474

Products & Services: Proteins, Expression, Isolation and Analysis

Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types

Authors: Madhuvanthi Kannan, Ganesh Vasan, Simon Haziza, Cheng Huang, Radosław Chrapkiewicz, Junjie Luo, Jessica A Cardin, Mark J Schnitzer, Vincent A Pieribone

Journal: Science

PubMed ID: 36378956

Doi: 10.1126/science.abm8797

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synDNA-a Synthetic DNA Spike-in Method for Absolute Quantification of Shotgun Metagenomic Sequencing

Authors: Livia S Zaramela, Megan Tjuanta, Oriane Moyne, Maxwell Neal, Karsten Zengler

Journal: mSystems

PubMed ID: 36317886

Doi: 10.1128/msystems.00447-22

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Transport of symbiont-encoded cellulases from the gill to the gut of shipworms via the enigmatic ducts of Deshayes: a 174-year mystery solved

Authors: Marvin A Altamia, Daniel L Distel

Journal: Proc Biol Sci

PubMed ID: 36350208

Doi: 10.1098/rspb.2022.1478

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Genome-wide identification of FAR gene family and functional analysis of NlFAR10 during embryogenesis in the brown planthopper Nilaparvata lugens

Authors: Xiaobin Fan, Wenqing Zhang

Journal: Int J Biol Macromol

PubMed ID: 36375673

Doi: 10.1016/j.ijbiomac.2022.11.075

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A basal actinopterygian melanocortin receptor: molecular and functional characterization of an Mc2r ortholog from the Senegal bichir (Polypterus senegalus).

Authors: Ciaran A Shaughnessy , Mary F Jensen , Robert M Dores

Journal: Gen Comp Endocrinol

PubMed ID: 35973587

Doi: 10.1016/j.ygcen.2022.114105

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A genetic approach to identify amino acids in Gcn1 required for Gcn2 activation

Authors: Susanne Gottfried , Siaosi M B M J Koloamatangi , Clement Daube , Anja H Schiemann , Evelyn Sattlegger

Journal: PLoS One

PubMed ID: 36441697

Doi: doi.org/10.1371/journal.pone.0277648

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Lipid metabolism reprogramming in colorectal cancer

Authors: Dan Chen, Xuebing Zhou, PengYu Yan, Chunyu Yang, Yuan Li, Longzhe Han, Xiangshan Ren

Journal: J Cell Biochem

PubMed ID: 36334309

Doi: 10.1002/jcb.30347

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Correction: Identification of novel HLA-A*11:01-restricted HPV16 E6/E7 epitopes and T-cell receptors for HPV-related cancer immunotherapy

Authors:

Journal: J Immunother Cancer

PubMed ID: 36332929

Doi: 10.1136/jitc-2022-004790corr1

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Autoimmune haemolytic anaemia

Authors: María Argüello Marina, Montserrat López Rubio, Lucía Castilla García

Journal: Med Clin (Barc)

PubMed ID: 36334945

Doi: 10.1016/j.medcli.2022.07.021

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Analysis of the HbpA Protein from Corynebacterium diphtheriae Clinical Isolates and Identification of a Putative Hemoglobin-Binding Site on HbpA

Authors: Lindsey R Lyman, Justine Schaeffer, Werner Ruppitsch, Michael P Schmitt

Journal: J Bacteriol

PubMed ID: 36346227

Doi: 10.1128/jb.00349-22

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Allosteric potentiation of GABA receptor single-channel conductance by netrin-1 during neuronal-excitation-induced inhibitory synaptic homeostasis

Authors: Elizabeth S Chan, Yang Ge, Yee Wah So, Yun-Fei Bai, Lidong Liu, Yu Tian Wang

Journal: Cell Rep

PubMed ID: 36323250

Doi: 10.1016/j.celrep.2022.111584

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A Δ42PD1 fusion-expressing DNA vaccine elicits enhanced adaptive immune response to HIV-1: the key role of TLR4

Authors: Lin Cheng, Xian Tang, Yun He, Bin Ju, Hui Wang

Journal: Virol J

PubMed ID: 36320043

Doi: 10.1186/s12985-022-01909-9

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Phosphate limitation intensifies negative effects of ocean acidification on globally important nitrogen fixing cyanobacterium

Authors: Futing Zhang, Zuozhu Wen, Shanlin Wang, Weiyi Tang, Ya-Wei Luo, Sven A Kranz, Haizheng Hong, Dalin Shi

Journal: Nat Commun

PubMed ID: 36344528

Doi: 10.1038/s41467-022-34586-x

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Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties

Authors: Hannah N Corman, Jessica N Ross, Francisco R Fields, Douglas A Shoue, Shaun W Lee, Mary Ann McDowell

Journal: Microbiol Spectr

PubMed ID: 36342284

Doi: 10.1128/spectrum.02658-22

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TARDBP promotes ovarian cancer progression by altering vascular endothelial growth factor splicing

Authors: Yutian He, Zhenbo OuYang, Wenwen Liu, Yu Chen, Qiushi Zhang

Journal: Oncogene

PubMed ID: 36369320

Doi: 10.1038/s41388-022-02539-9

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Quantum Dot-Based Molecular Beacons for Quantitative Detection of Nucleic Acids with CRISPR/Cas(N) Nucleases

Authors: Christopher M Green, Joseph Spangler, Kimihiro Susumu, David A Stenger, Igor L Medintz, Sebastián A Díaz

Journal: ACS Nano

PubMed ID: 36378103

Doi: 10.1021/acsnano.2c07749

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Characteristics and Resistance to Cisplatin of Human Neuroblastoma Cells Co-Cultivated with Immune and Stromal Cells

Authors: Kristina V Kitaeva , Daria S Chulpanova , Margarita N Zhuravleva , Ivan Yu Filin , Ruslan M Deviatiiarov , Alyssa C Ballard-Reisch , Albert A Rizvanov , Valeriya V Solovyeva

Journal: Bioengineering (Basel) .

PubMed ID: 36354566

Doi: 10.3390/bioengineering9110655

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Antibody and T Cell Immune Responses to SARS-CoV-2 Peptides in COVID-19 Convalescent Patients

Authors: Kristina V Kitaeva , Daria S Chulpanova , Margarita N Zhuravleva , Ivan Yu Filin , Ruslan M Deviatiiarov , Alyssa C Ballard-Reisch , Albert A Rizvanov , Valeriya V Solovyeva

Journal: Bioengineering (Basel) .

PubMed ID: 36354566

Doi: 10.3389/fmicb.2022.842232

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Pathogenic Interleukin-10 Receptor Alpha Variants in Humans - Balancing Natural Selection and Clinical Implications

Authors: Dominik Aschenbrenner, Ziqing Ye, Ying Zhou, Wenhui Hu, Isabel Brooks, Isabelle Williams, Melania Capitani, Lisa Gartner, Daniel Kotlarz, Scott B Snapper, Christoph Klein, Aleixo M Muise, Brian D Marsden, Ying Huang, Holm H Uhlig

Journal: J Clin Immunol

PubMed ID: 36370291

Doi: 10.1007/s10875-022-01366-7

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An engineered (CAGA)-EGFP cell-based biosensor for high-content and accurate detection of active TGF-β

Authors: Qian Ruan, Xuezhen Lin, Lixia Wang, Niu Wang, Yu Zhao, Hao Wang, Fu-Ying Tian, Ning Hu, Ying Li, Bo Zhao

Journal: Biosens Bioelectron

PubMed ID: 36403492

Doi: 10.1016/j.bios.2022.114884

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Identification of African swine fever virus MGF505-2R as a potent inhibitor of innate immunity in vitro

Authors: Huaguo Huang, Wen Dang, Zhengwang Shi, Mingyang Ding, Fan Xu, Tao Li, Tao Feng, Haixue Zheng, Shuqi Xiao

Journal: Virol Sin

PubMed ID: 36442611

Doi: 10.1016/j.virs.2022.11.009

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Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism

Authors: Jie Shen, Qian Zha, Qian-Hua Yang, Yue-Qian Zhou, Xiao Liang, Ying-Jie Chen, Gui-Xia Qi, Xiao-Jin Zhang, Wen-Bing Yao, Xiang-Dong Gao, Song Chen

Journal: Acta Pharmacol Sin

PubMed ID: 36357669

Doi: 10.1038/s41401-022-01014-1

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A reversible cell penetrating peptide-cargo linkage allows dissection of cell penetrating peptide- and cargo-dependent effects on internalization and identifies new functionalities of putative endolytic peptides

Authors: Daniel P Morris, Lucy C Snipes, Stephanie A Hill, Michael M Woods, Maria M Mbugua, Lydia R Wade, Jonathan L McMurry

Journal: Front Pharmacol .

PubMed ID: 36479201

Doi: 10.3389/fphar.2022.1070464

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Chaperoning activity of the cyclophilin family prevents tau aggregation

Authors: Shannon E Hill , Abigail R Esquivel , Santiago Rodriguez Ospina , Lauren M Rahal , Chad A Dickey , Laura J Blair

Journal: Protein Sci

PubMed ID: 36305768

Doi: 10.1002/pro.4448

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Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes

Authors: Zeyu Jin , Li Wan , Yuqi Zhang , Xuecheng Li , Yong Cao , Haobin Liu , Shengyao Fan , Du Cao , Zhengmao Wang , Xiaobo Li , Junmin Pan , Meng-Qiu Dong , Jianping Wu , Zhen Yan

Journal: Cell

PubMed ID: 36413996

Doi: 10.1016/j.cell.2022.10.030

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Structure/function studies on the activation motif of two non-mammalian Mrap1 orthologs, and observations on the phylogeny of Mrap1, including a novel characterization of an Mrap1 from the chondrostean fish, Polyodon spathula.

Authors: Robert M. Dores , Greer McKinley, Audrey Meyers, Morgan Martin and Ciaran A. Shaughnessy

Journal: Biomolecules

Doi: 10.3390/biom12111681

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Rice FLOURY ENDOSPERM22, encoding a pentatricopeptide repeat protein, is involved in both mitochondrial RNA splicing and editing and is crucial for endosperm development

Authors: Hang Yang , Yunlong Wang , Yunlu Tian , Xuan Teng , Zehui Lv , Jie Lei , Erchao Duan , Hui Dong , Xue Yang , Yuanyan Zhang , Yinglun Sun , Xiaoli Chen , Xiuhao Bao , Rongbo Chen , Chuanwei Gu , Yipeng Zhang , Xiaokang Jiang , Wenyu Ma , Pengcheng Zhang , Yi Ji , Yu Zhang , Yihua Wang , Jianmin Wan

Journal: J Integr Plant Biol

PubMed ID: 36333887

Doi: 10.1111/jipb.13402

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The effect of mutations on binding interactions between the SARS-CoV-2 receptor binding domain and neutralizing antibodies B38 and CB6

Authors: Jonathan E Barnes, Peik K Lund-Andersen, Jagdish Suresh Patel, F Marty Ytreberg

Journal: Sci Rep

PubMed ID: 36335244

Doi: 10.1038/s41598-022-23482-5

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Design and optimization of enzymatic activity in a de novo β-barrel scaffold

Authors: Yakov Kipnis, Anissa Ouald Chaib, Anastassia A Vorobieva, Guangyang Cai, Gabriella Reggiano, Benjamin Basanta, Eshan Kumar, Peer R E Mittl, Donald Hilvert, David Baker

Journal: Protein Sci

PubMed ID: 36305767

Doi: 10.1002/pro.4405

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Association of neutrophil extracellular traps with fistula healing in patients with complex perianal fistulising Crohn's disease

Authors: Dongxing Cao, Keyu Qian, Ying Zhao, Jie Hong, Haoyan Chen, Xiaohui Wang, Nailin Yang, Cheng Zhang, Jingkai Cao, Keyu Jia, Guangyu Wu, Mingming Zhu, Jun Shen, Ye Zhang, Zhe Cui, Zheng Wang

Journal: J Crohns Colitis

PubMed ID: 36322703

Doi: 10.1093/ecco-jcc/jjac171

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Ectopic circSTK39 expression ameliorates hydrogen peroxide-induced human lens epithelial cell apoptosis and oxidative stress through the miR-125a-5p/ERCC6 pathway

Authors: Ming Guo, Fanfan Su, Yao Chen, Bo Su

Journal: Curr Eye Res

PubMed ID: 36322706

Doi: 10.1080/02713683.2022.2143529

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Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomes

Authors: Neil Berry, Deborah Ferguson, Sarah Kempster, Jo Hall, Claire Ham, Adrian Jenkins, Vicky Rannow, Elaine Giles, Rose Leahy, Sara Goulding, Arturo Fernandez, Yemisi Adedeji, Sandrine Vessillier, Deepa Rajagopal, Sandra Prior, Yann Le Duff, Matthew Hurley, Sarah Gilbert, Martin Fritzsche, Ryan Mate, Nicola Rose, Robert J Francis, Kirsty MacLellan-Gibson, Alejandro Suarez-Bonnet, Simon Priestnall, Neil Almond

Journal: Sci Rep

PubMed ID: 36333445

Doi: 10.1038/s41598-022-23339-x

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Developmentally regulated mitochondrial biogenesis and cell death competence in maize pollen

Authors: Karen C Chamusco, May N Milazzo, Kanchan S Bhan, Terry L Kamps, Prestina Smith, Modupeoluwa Durojaiye, Cristina D Moreira, Maria Gallo, Christine D Chase

Journal: BMC Plant Biol

PubMed ID: 36316635

Doi: 10.1186/s12870-022-03897-y

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A microbial transporter of the dietary antioxidant ergothioneine

Authors: Daniel G Dumitrescu, Elizabeth M Gordon, Yekaterina Kovalyova, Anna B Seminara, Brianna Duncan-Lowey, Emily R Forster, Wen Zhou, Carmen J Booth, Aimee Shen, Philip J Kranzusch, Stavroula K Hatzios

Journal: Cell

PubMed ID: 36347253

Doi: 10.1016/j.cell.2022.10.008

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