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Potential of a novel flagellin epitope as a broad-spectrum vaccine candidate against enteric fever

Authors: Shania Vij, Reena Thakur, Laxmi Kumari, Chander Raman Suri, Praveen Rishi

Journal: Microb Pathog

PubMed ID: 36494021

Doi: 10.1016/j.micpath.2022.105936

Products & Services: Peptide Synthesis

Proteolytic activation of human-specific Olduvai domains by the furin protease

Authors: Ashley Pacheco, Aaron Issaian, Jonathan Davis, Nathan Anderson, Travis Nemkov, Natasia Paukovich, Morkos A Henen, Beat Vögeli, James M Sikela, Kirk Hansen

Journal: Int J Biol Macromol

PubMed ID: 36581038

Doi: 10.1016/j.ijbiomac.2022.12.260

Products & Services: Proteins, Expression, Isolation and Analysis

Impact of latency-reversing agents on human macrophage physiology

Authors: Laurent Hany, Marc-Olivier Turmel, Corinne Barat, Michel Ouellet, Michel J Tremblay

Journal: Immun Inflamm Dis

PubMed ID: 36480653

Doi: 10.1002/iid3.590

Products & Services: Proteins, Expression, Isolation and Analysis

Combining intramuscular and intranasal homologous prime-boost with a chimpanzee adenovirus-based COVID-19 vaccine elicits potent humoral and cellular immune responses in mice

Authors: Xingxing Li , Ling Wang , Jingjing Liu , Enyue Fang , Xiaohui Liu , Qinhua Peng , Zelun Zhang , Miao Li , Xinyu Liu , Xiaohong Wu , Danhua Zhao , Lihong Yang , Jia Li , Shouchun Cao , Yanqiu Huang , Leitai Shi , Hongshan Xu , Yunpeng Wang , Yue Suo , Guangzhi Yue , Jianhui Nie , Weijin Huang , Wenjuan Li , Yuhua Li

Journal: Emerg Microbes Infect

PubMed ID: 35775819

Doi: 10.1080/22221751.2022.2097479

Products & Services: Peptides and Peptide Library

A frontline, rapid, nucleic acid-based Fusarium circinatum detection system using CRISPR/Cas12a combined with recombinase polymerase amplification

Authors: Zhenpeng Chen , Xiao Yang , Hongming Xia , Cuiping Wu , Jing Yang , Tingting Dai

Journal: Plant Dis

PubMed ID: 36480733

Doi: 10.1094/PDIS-05-22-1234-RE

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Mitochondrial GPAT-derived LPA controls auxin-dependent embryonic and postembryonic development

Authors: Qianru Jia , Yang Bai , Hui Xu , Qingyun Liu , Wenyan Li , Teng Li , Feng Lin , Like Shen , Wei Xuan , Wenhua Zhang , Qun Zhang

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36454754

Doi: 10.1073/pnas.2212881119

Products & Services: Proteins, Expression, Isolation and Analysis

clbP Gene, a Potential New Member of the -Lactamase Family

Authors: Adel Azour , Charbel Al-Bayssari , Lucile Pinault , Saïd Azza , Jean-Marc Rolain ,Seydina M. Diene

Journal: Int. J. Mol. Sci

Doi: ijms232415642

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Bazi Bushen capsule attenuates cognitive deficits by inhibiting microglia activation and cellular senescence

Authors: Chuanyuan Ji, Cong Wei, Mengnan Li, Shuang Shen, Shixiong Zhang, Yunlong Hou, Yiling Wu

Journal: Pharm Biol

PubMed ID: 36263579

Doi: 10.1080/13880209.2022.2131839

Products & Services: Proteins, Expression, Isolation and Analysis

EYFP fusions to HD-Zip IV transcription factors enhance their stability and lead to phenotypic changes in

Authors: Bibek Subedi, Kathrin Schrick

Journal: Plant Signal Behav

PubMed ID: 36154907

Doi: 10.1080/15592324.2022.2119013

Products & Services: Proteins, Expression, Isolation and Analysis

Design of a H O -generating P450 fusion protein for high yield fatty acid conversion

Authors: Daniele Giuriato, Danilo Correddu, Gianluca Catucci, Giovanna Di Nardo, Cristiano Bolchi, Marco Pallavicini, Gianfranco Gilardi

Journal: Protein Sci

PubMed ID: 36334042

Doi: 10.1002/pro.4501

Products & Services: Plasmid DNA Preparation

A Recombinant Genotype I Japanese Encephalitis Virus Expressing a Gaussia Luciferase Gene for Antiviral Drug Screening Assay and Neutralizing Antibodies Detection

Authors: Chenxi Li , Xuan Chen , Jingbo Hu , Daoyuan Jiang , Demin Cai , Yanhua Li

Journal: Int J Mol Sci

PubMed ID: 36555192

Doi: 10.3390/ijms232415548

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Hepatic neddylation deficiency triggers fatal liver injury via inducing NF-κB-inducing kinase in mice

Authors: Cheng Xu , Hongyi Zhou , Yulan Jin , Khushboo Sahay , Anna Robicsek , Yisong Liu , Kunzhe Dong , Jiliang Zhou , Amanda Barrett , Huabo Su , Weiqin Chen

Journal: Nat Commun

PubMed ID: 36526632

Doi: 10.1038/s41467-022-35525-6

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A Rapid Label-Free Disposable Electrochemical Salivary Point-of-Care Sensor for SARS-CoV-2 Detection and Quantification

Authors: Nadia Farsaeivahid, Christian Grenier, Sheyda Nazarian, Ming L Wang

Journal: Sensors (Basel)

PubMed ID: 36617031

Doi: 10.3390/s23010433

Products & Services: Proteins, Expression, Isolation and Analysis

Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape

Authors: Roberta Marzi, Jessica Bassi, Chiara Silacci-Fregni, Istvan Bartha, Francesco Muoio, Katja Culap, Nicole Sprugasci, Gloria Lombardo, Christian Saliba, Elisabetta Cameroni, Antonino Cassotta, Jun Siong Low, Alexandra C Walls, Matthew McCallum, M Alejandra Tortorici, John E Bowen, Exequiel A Dellota, Josh R Dillen, Nadine Czudnochowski, Laura Pertusini, Tatiana Terrot, Valentino Lepori, Maciej Tarkowski, Agostino Riva, Maira Biggiogero, Alessandra Franzetti-Pellanda, Christian Garzoni, Paolo Ferrari, Alessandro Ceschi, Olivier Giannini, Colin Havenar-Daughton, Amalio Telenti, Ann Arvin, Herbert W Virgin, Federica Sallusto, David Veesler, Antonio Lanzavecchia, Davide Corti, Luca Piccoli

Journal: iScience

PubMed ID: 36507220

Doi: 10.1016/j.isci.2022.105726

Products & Services: Molecular Biology Reagents

Human Dectin-1 is -glycosylated and serves as a ligand for C-type lectin receptor CLEC-2

Authors: Shojiro Haji, Taiki Ito, Carla Guenther, Miyako Nakano, Takashi Shimizu, Daiki Mori, Yasunori Chiba, Masato Tanaka, Sushil K Mishra, Janet A Willment, Gordon D Brown, Masamichi Nagae, Sho Yamasaki

Journal: Elife

PubMed ID: 36479973

Doi: 10.7554/eLife.83037

Products & Services: Synthetic sgRNA and crRNA Service

Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8 T cells eradicates peritoneal metastases in mouse models

Authors: Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Ángela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Irene Olivera, Elizabeth Bolaños, José González-Gomariz, Maite Álvarez, Iñaki Etxeberria, Belen Palencia, Álvaro Teijeira, Ignacio Melero, Pedro Berraondo, Fernando Aranda

Journal: Oncoimmunology

PubMed ID: 36531687

Doi: 10.1080/2162402X.2022.2147317

Products & Services: Combinatorial DNA Libraries

Unsterile production of a polyhydroxyalkanoate copolymer by Halomonas cupida J9

Authors: Yujie Liu, Wanwan Zhao, Siqi Wang, Kaiyue Huo, Yaping Chen, Hongfu Guo, Shufang Wang, Ruihua Liu, Chao Yang

Journal: Int J Biol Macromol

PubMed ID: 36347367

Doi: 10.1016/j.ijbiomac.2022.10.275

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Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1

Authors: Yalan Wang, Qiubing Chen, Shuang Wu, Xinyu Sun, Runting Yin, Zhen Ouyang, Hao Yin, Yuan Wei

Journal: Acta Pharmaceutica Sinica B

Doi: 10.1016/j.apsb.2023.01.009

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Brown goat yogurt: Metabolomics, peptidomics, and sensory changes during production

Authors: R Zhang, W Jia

Journal: J Dairy Sci

PubMed ID: 36586795

Doi: 10.3168/jds.2022-22654

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Cell membrane-camouflaged liposomes and neo-peptide-loaded liposomes with TLR agonist R848 provides a prime and boost strategy for efficient personalized cancer vaccine therapy

Authors: Lu Shi , Hongchen Gu

Journal: Nanomedicine

PubMed ID: 36584738

Doi: 10.1016/j.nano.2022.102648

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An algal lectin griffithsin inhibits Hantaan virus infection in vitro and in vivo

Authors: Yajing Zhao , Ningbo Zhao, Yanxing Cai , Hui Zhang, Jia Li, Jiaqi Liu , Chuantao Ye , Yuan Wang , Yamei Dang , Wanying Li , He Liu , Lianqing Zhang , Yuexiang Li , Liang Zhang , Linfeng Cheng , Yangchao Dong , Zhikai Xu , Yingfeng Lei , Lu Lu , Yingjuan Wang , Wei Ye , Fanglin Zhang

Journal: Front Cell Infect Microbiol .

PubMed ID: 36579342

Doi: 10.3389/fcimb.2022.881083

Products & Services: Gene Services

Neutraligands of C5a can potentially occlude the interaction of C5a with the complement receptors C5aR1 and C5aR2

Authors: Aurosikha Das, Manaswini Ghosh, Pulkit Kr Gupta, Soumendra Rana

Journal: J Cell Biochem

PubMed ID: 36565188

Doi: 10.1002/jcb.30360

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Pseudomonas aeruginosa Promotes Persistence of Stenotrophomonas maltophilia via Increased Adherence to Depolarized Respiratory Epithelium

Authors: Melissa S McDaniel, Natalie R Lindgren, Caitlin E Billiot, Kristina N Valladares, Nicholas A Sumpter, W Edward Swords

Journal: Microbiol Spectr

PubMed ID: 36472421

Doi: 10.1128/spectrum.03846-22

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A chromosome-level genome assembly reveals that tandem-duplicated CYP706V oxidase genes control oridonin biosynthesis in the shoot apex of Isodon rubescens

Authors: Yuwei Sun, Jie Shao, Haili Liu, Hua Wang, Guangyi Wang, Jianhua Li, Yaping Mao, Zhuo Chen, Ke Ma, Lin Xu, Yong Wang

Journal: Mol Plant

PubMed ID: 36518072

Doi: 10.1016/j.molp.2022.12.007

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Molecular cloning and functional characterization of melanocortin-3 receptor in grass carp (Ctenopharyngodon idella)

Authors: Haolin Mo, Huixia Yu, Yang Li, Timothy P C Ezeorba, Zhihao Zhang, Mingxin Yao, Jiajia Yu, Dongmei Xiong, Haixia Liu, Lixin Wang

Journal: Fish Physiol Biochem

PubMed ID: 36547499

Doi: 10.1007/s10695-022-01164-3

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Mitoguardin-2–mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation

Authors: Zhouping Hong , Jyoti Adlakha , Neng Wan , Emily Guinn , Fabian Giska , Kallol Gupta , Thomas J Melia , Karin M Reinisch

Journal: J Cell Biol .

PubMed ID: 36282247

Doi: 10.1083/jcb.202207022

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An auristatin-based peptide-drug conjugate targeting Kita-Kyushu lung cancer antigen 1 for precision chemoradiotherapy in gastric cancer

Authors: Xiaotong Chen , Fangcen Liu , Xiaoxiao Yu , Lin Li , Jiayao Yan , Xinjie Chen , Qin Liu , Baorui Liu

Journal: Eur J Med Chem

PubMed ID: 35932567

Doi: 10.1016/j.ejmech.2022.114617

Products & Services: Recombinant Antibody Expression

Independently evolved viral effectors convergently suppress DELLA protein SLR1-mediated broad-spectrum antiviral immunity in rice

Authors: Lulu Li , Hehong Zhang , Zihang Yang , Chen Wang , Shanshan Li , Chen Cao , Tongsong Yao , Zhongyan Wei , Yanjun Li , Jianping Chen , Zongtao Sun

Journal: Nat Commun

PubMed ID: 36376330

Doi: doi.org/10.1038/s41467-022-34649-z

Products & Services: Catalog Antibody

Optimized prime editing in monocot plants using PlantPegDesigner and engineered plant prime editors (ePPEs)

Authors: Shuai Jin , Qiupeng Lin , Qiang Gao , Caixia Gao

Journal: Nat Protoc

PubMed ID: 36434096

Doi: doi.org/10.1038/s41596-022-00773-9

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A gold nanoparticles-based lateral flow assay utilizing baculovirus expressed recombinant nucleocapsid and receptor binding domain proteins for serodetection of IgG and IgM against SARS-CoV-2

Authors: Reda Salem, Amany M Elshamy, Noha Kamel, Soha Younes, Ohoud M Marie, Fatma R Waly, Alaa A El-Kholy, Wael Elmenofy

Journal: Biotechnol Lett

PubMed ID: 36319880

Doi: 10.1007/s10529-022-03316-0

Products & Services: Mammalian Expression

Neutralization Epitopes in Trimer and Pentamer Complexes Recognized by Potent Cytomegalovirus-Neutralizing Human Monoclonal Antibodies

Authors: Yuanbao Ai, Changwen Wu, Ming Zhang, Dabbu Kumar Jaijyan, Tong Liu, Lipeng Zan, Nan Li, Wei Yu, Yueming Wang, Xiaohui Yuan, Chengming Li, Weihong Zheng, Hua Zhu, Hua-Xin Liao

Journal: Microbiol Spectr

PubMed ID: 36342276

Doi: 10.1128/spectrum.01393-22

Products & Services: Proteins, Expression, Isolation and Analysis

Seroprevalence of AAV neutralizing antibodies in males with Duchenne muscular dystrophy

Authors: Sumit Verma, Stella N Nwosu, Raj Razdan, Saila R Upadhyayula, Han C Phan, Abubakarr A Koroma, Isai Leguizamo, Natalie S Correa, Michael Kuipa, David Lee, Thomas H Vanderford, Matthew R Gardner

Journal: Hum Gene Ther

PubMed ID: 36324212

Doi: 10.1089/hum.2022.081

Products & Services: Plasmid DNA Preparation

The two Gtsf paralogs in silkworms orthogonally activate their partner PIWI proteins for target cleavage

Authors: Natsuko Izumi, Keisuke Shoji, Takashi Kiuchi, Susumu Katsuma, Yukihide Tomari

Journal: RNA

PubMed ID: 36319089

Doi: 10.1261/rna.079380.122

Products & Services: GenParts™ DNA Fragments

Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation

Authors: Eisho Kanemitsu, Xiangdong Zhao, Keiko Iwaisako, Asuka Inoue, Akihide Takeuchi, Shintaro Yagi, Hidetoshi Masumoto, Hiroaki Ohara, Motoyasu Hosokawa, Tomonari Awaya, Junken Aoki, Etsuro Hatano, Shinji Uemoto, Masatoshi Hagiwara

Journal: Transl Res

PubMed ID: 36347491

Doi: 10.1016/j.trsl.2022.11.003

Products & Services: Codon Optimization

IgA quantification as a good predictor of the neutralizing antibodies levels after vaccination against SARS-CoV-2

Authors: Lorena O Fernandes-Siqueira, Bruna G Sousa, Carlos E Cleto, Luciana S Wermelinger, Beatriz L L Caetano, Agatha R Pacheco, Simone M Costa, Fabio C L Almeida, Gustavo C Ferreira, Didier Salmon, Ada M B Alves, Andrea T Da Poian

Journal: J Clin Virol Plus

PubMed ID: 36349309

Doi: 10.1016/j.jcvp.2022.100121

Development of fluorescent peptide G protein-coupled receptor activation biosensors for NanoBRET characterization of intracellular allosteric modulators

Authors: James P Farmer, Shailesh N Mistry, Charles A Laughton, Nicholas D Holliday

Journal: FASEB J

PubMed ID: 36183332

Doi: 10.1096/fj.202201024R

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A human adenovirus encoding IFN-γ can transduce Tasmanian devil facial tumour cells and upregulate MHC-I

Authors: Ahab N Kayigwe, Jocelyn M Darby, A Bruce Lyons, Amanda L Patchett, Leszek Lisowski, Guei-Sheung Liu, Andrew S Flies

Journal: J Gen Virol

PubMed ID: 36382885

Doi: 10.1099/jgv.0.001812

Products & Services: Recombinant Antibody Expression

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies

Authors: Nadeem Murtaza, Annie A Cheng, Chad O Brown, Durga Praveen Meka, Shuai Hong, Jarryll A Uy, Joelle El-Hajjar, Neta Pipko, Brianna K Unda, Birgit Schwanke, Sansi Xing, Bhooma Thiruvahindrapuram, Worrawat Engchuan, Brett Trost, Eric Deneault, Froylan Calderon de Anda, Bradley W Doble, James Ellis, Evdokia Anagnostou, Gary D Bader, Stephen W Scherer, Yu Lu, Karun K Singh

Journal: Cell Rep

PubMed ID: 36417873

Doi: 10.1016/j.celrep.2022.111678

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TMT-Based Comparative Peptidomics Analysis of Rice Seedlings under Salt Stress: An Accessible Method to Explore Plant Stress-Tolerance Processing

Authors: Wanlu Ma, Chenchen Zhang, Wei Zhang, Pijie Sheng, Minyan Xu, Ying Ni, Meng Chen, Beijiu Cheng, Xin Zhang

Journal: J Proteome Res

PubMed ID: 36351196

Doi: 10.1021/acs.jproteome.2c00318

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Novel Antibody Exerts Antitumor Effect through Downregulation of CD147 and Activation of Multiple Stress Signals

Authors: Keisuke Fukuchi, Kayoko Nanai, Hiroshi Yuita, Chikako Maru, Jun Tsukada, Masato Ishigami, Yoko Nagai, Yoko Nakano, Chigusa Yoshimura, Kozo Yoneda, Masato Amano, Kensuke Nakamura, Yoko Oda, Haruyuki Nishigohri, Shoji Yamamoto, Yusuke Ohnishi-Totoki, Koichiro Inaki, Hironobu Komori, Rika Nakano, Yoshiyuki Kanari, Atsuko Nishida, Yumi Matsui, Satoko Funo, Sayako Takahashi, Toshiaki Ohtsuka, Toshinori Agatsuma

Journal: J Oncol

PubMed ID: 36385956

Doi: 10.1155/2022/3552793

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Recombinant Vaccinia Virus Expressing Apical Membrane Antigen 1 or Microneme Protein Enhances Protection against Infection in Mice

Authors: Min-Ju Kim, Ki-Back Chu, Su-Hwa Lee, Hae-Ji Kang, Keon-Woong Yoon, Md Atique Ahmed, Fu-Shi Quan

Journal: Trop Med Infect Dis

PubMed ID: 36355892

Doi: 10.3390/tropicalmed7110350

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Accelerated Polyethylene Terephthalate (PET) Enzymatic Degradation by Room Temperature Alkali Pre-treatment for Reduced Polymer Crystallinity

Authors: Sariah Giraldo-Narcizo, Nihal Guenani, Ana María Sánchez-Pérez, Antonio Guerrero

Journal: Chembiochem

PubMed ID: 36341520

Doi: 10.1002/cbic.202200503

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Intrinsically Unstructured Sequences in the mRNA 3' UTR Reduce the Ability of Poly(A) Tail to Enhance Translation

Authors: Wan-Jung C Lai, Mingyi Zhu, Margarita Belinite, Gregory Ballard, David H Mathews, Dmitri N Ermolenko

Journal: J Mol Biol

PubMed ID: 36368412

Doi: 10.1016/j.jmb.2022.167877

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Multivalent binding of the hub protein LC8 at a newly discovered site in 53BP1

Authors: Jesse Howe, Austin Weeks, Patrick Reardon, Elisar Barbar

Journal: Biophys J

PubMed ID: 36335430

Doi: 10.1016/j.bpj.2022.11.006

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Plant-Produced S1 Subunit Protein of SARS-CoV-2 Elicits Immunogenic Responses in Mice

Authors: Chalisa Panapitakkul, Narach Khorattanakulchai, Kaewta Rattanapisit, Theerakarn Srisangsung, Balamurugan Shanmugaraj, Supranee Buranapraditkun, Chutitorn Ketloy, Eakachai Prompetchara, Waranyoo Phoolcharoen

Journal: Vaccines (Basel)

PubMed ID: 36423056

Doi: 10.3390/vaccines10111961

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COPA A-to-I RNA editing hijacks endoplasmic reticulum stress to promote metastasis in colorectal cancer

Authors: Shu-Yang Wang, Ling-Jie Zhang, Guo-Jun Chen, Qi-Qi Ni, Yuan Huang, Dan Zhang, Fang-Yi Han, Wen-Feng He, Li-Ling He, Yan-Qing Ding, Hong-Li Jiao, Ya-Ping Ye

Journal: Cancer Lett

PubMed ID: 36336148

Doi: 10.1016/j.canlet.2022.215995

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Health safety of parabens evaluated by selected in vitro methods

Authors: L Svobodova, K Kejlova, M Rucki, J Chrz, P Kubincova, M Dvorakova, H Kolarova, D Jirova

Journal: Regul Toxicol Pharmacol

PubMed ID: 36455707

Doi: 10.1016/j.yrtph.2022.105307

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Production of cytoplasmic type citrus leprosis virus-like particles by plant molecular farming

Authors: Oscar A Ortega-Rivera, Veronique Beiss, Elizabeth O Osota, Soo Khim Chan, Sweta Karan, Nicole F Steinmetz

Journal: Virology

PubMed ID: 36434906

Doi: 10.1016/j.virol.2022.11.004

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Recovery of Siniperca chuatsi rhabdovirus from cloned cDNA

Authors: Xiaoyu Liu, Xiaodong Zhang, Zhendong Xu, Zhiyang Huang, Junyao Zhong, Yinzhi Zhu, Yongwei Wei

Journal: J Fish Dis

PubMed ID: 36321410

Doi: 10.1111/jfd.13726

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High anti-SARS-CoV-2 seroprevalence among unvaccinated mother-child pairs from a rural setting in north-eastern Tanzania during the second wave of COVID-19

Authors: Omari Abdul Msemo, Laura Pérez-Alós, Daniel T R Minja, Cecilie Bo Hansen, Samwel Gesase, George Mtove, Joyce Mbwana, Victoria Marie Linderod Larsen, Emilie Caroline Skuladottir Bøgestad, Louise Groth Grunnet, Dirk Lund Christensen, Ib Christian Bygbjerg, David Burgner, Christentze Schmiegelow, Peter Garred, Line Hjort

Journal: IJID Reg

PubMed ID: 36466214

Doi: 10.1016/j.ijregi.2022.11.011

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Endotoxin-free gram-negative bacterium as a system for production and secretion of recombinant proteins

Authors: Ehud Shahar, Ken Emquies, Itai Bloch, Dalia Eliahu, Ran Ben Adiva, Jacob Pitcovski, Itamar Yadid

Journal: Appl Microbiol Biotechnol

PubMed ID: 36445389

Doi: 10.1007/s00253-022-12295-1

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In silico design, production and immunization evaluation of a recombinant bivalent fusion protein candidate vaccine against E coli O157:H7

Authors: Hossein Samiei, Shahram Nazarian, Abass Hajizade, Emad Kordbacheh

Journal: Int Immunopharmacol

PubMed ID: 36450206

Doi: 10.1016/j.intimp.2022.109464

Products & Services: Proteins, Expression, Isolation and Analysis

An insecticide target in mechanoreceptor neurons

Authors: Xiaomu Qiao , Xiaoyu Zhang , Zhendong Zhou , Lei Guo , Weiping Wu , Suhan Ma , Xinzhong Zhang , Craig Montell , Jia Huang

Journal: Sci Adv

PubMed ID: 36417522

Doi: 10.1126/sciadv.abq3132

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DNA topology regulates PAM-Cas9 interaction and DNA unwinding to enable near-PAMless cleavage by thermophilic Cas9

Authors: Ya-Jing Shi , Min Duan , Jun-Mei Ding , Fan-Qi Wang , Li-Li Bi , Cai-Xiang Zhang , Yi-Zhou Zhang , Jun-Yi Duan , An-Hui Huang , Xin-Lin Lei , Hao Yin , Ying Zhang

Journal: Mol Cell

PubMed ID: 36272409

Doi: 10.1016/j.molcel.2022.09.032

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Rearranged endogenized plant pararetroviruses as evidence of heritable RNA-based immunity

Authors: Adrian A Valli, Irene Gonzalo-Magro, Diego H Sanchez

Journal: Mol Biol Evol

PubMed ID: 36322467

Doi: 10.1093/molbev/msac240

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Activation of a novel αAR-spinophilin-cofilin axis determines the effect of α adrenergic drugs on fear memory reconsolidation

Authors: Shalini Saggu, Yunjia Chen, Christopher Cottingham, Hasibur Rehman, Hongxia Wang, Sixue Zhang, Corinne Augelli-Szafran, Sumin Lu, Nevin Lambert, Kai Jiao, Xin-Yun Lu, Qin Wang

Journal: Mol Psychiatry

PubMed ID: 36357671

Doi: 10.1038/s41380-022-01851-w

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Ornate, large, extremophilic (OLE) RNA forms a kink turn necessary for OapC protein recognition and RNA function

Authors: Seth E Lyon, Kimberly A Harris, Nicole B Odzer, Sarah G Wilkins, Ronald R Breaker

Journal: J Biol Chem

PubMed ID: 36336078

Doi: 10.1016/j.jbc.2022.102674

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FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis

Authors: Allison V Mitchell, Ling Wu, C James Block, Mu Zhang, Justin Hackett, Douglas B Craig, Wei Chen, Yongzhong Zhao, Bin Zhang, Yongjun Dang, Xiaohong Zhang, Shengping Zhang, Chuangui Wang, Heather Gibson, Lori A Pile, Benjamin Kidder, Larry Matherly, Zhe Yang, Yali Dou, Guojun Wu

Journal: Nat Commun

PubMed ID: 36319643

Doi: 10.1038/s41467-022-34239-z

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Antibody-mediated delivery of CRISPR-Cas9 ribonucleoproteins in human cells

Authors: Stephanie Ubiparipovic, Daniel Christ, Romain Rouet

Journal: Protein Eng Des Sel

PubMed ID: 36336952

Doi: 10.1093/protein/gzac011

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The Immunological Epigenetic Landscape of the Human Life Trajectory

Authors: Iva Juříčková, Michael Hudec, Felix Votava, Jan Vosáhlo, Saak Victor Ovsepian, Marie Černá, Valerie Bríd O'Leary

Journal: Biomedicines

PubMed ID: 36428462

Doi: 10.3390/biomedicines10112894

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Evolutionary gain and loss of a plant pattern-recognition receptor for HAMP recognition

Authors: Simon Snoeck, Bradley W Abramson, Anthony G K Garcia, Ashley N Egan, Todd P Michael, Adam Steinbrenner

Journal: Elife

PubMed ID: 36377784

Doi: 10.7554/eLife.81050

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Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2

Authors: Ren-Lei Ji, Shan-Shan Jiang, Ya-Xiong Tao

Journal: Biomolecules

PubMed ID: 36358958

Doi: 10.3390/biom12111608

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Functional and molecular dissection of HCMV long non-coding RNAs

Authors: Sungwon Lee, Hyewon Kim, Ari Hong, Jaewon Song, Sungyul Lee, Myeonghwan Kim, Sung-Yeon Hwang, Dongjoon Jeong, Jeesoo Kim, Ahyeon Son, Young-Suk Lee, V Narry Kim, Jong-Seo Kim, Hyeshik Chang, Kwangseog Ahn

Journal: Sci Rep

PubMed ID: 36369338

Doi: 10.1038/s41598-022-23317-3

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ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation

Authors: Alexander R van Vliet, George N Chiduza, Sarah L Maslen, Valerie E Pye, Dhira Joshi, Stefano De Tito, Harold B J Jefferies, Evangelos Christodoulou, Chloë Roustan, Emma Punch, Javier H Hervás, Nicola O'Reilly, J Mark Skehel, Peter Cherepanov, Sharon A Tooze

Journal: Mol Cell

PubMed ID: 36347259

Doi: 10.1016/j.molcel.2022.10.017

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KCNQ1OT1 sponges miR-34a to promote malignant progression of malignant melanoma via upregulation of the STAT3/PD-L1 axis

Authors: Xin Wang, Zhiyao Ren, Yunfeng Xu, Xiang Gao, Hainian Huang, Fei Zhu

Journal: Environ Toxicol

PubMed ID: 36399467

Doi: 10.1002/tox.23687

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Epsilon-caprolactone-modified polyethylenimine as a genetic vehicle for stem cell-based bispecific antibody and exosome synergistic therapy

Authors: Yan Tan, Jiali Cai, Zhiyong Wang

Journal: Regen Biomater

PubMed ID: 36683744

Doi: 10.1093/rb/rbac090

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Immune Phenotypes and Target Antigens of Clonally Expanded Bone Marrow T Cells in Treatment-Naïve Multiple Myeloma

Authors: Carlotta Welters, María Fernanda Lammoglia Cobo, Christian Alexander Stein, Meng-Tung Hsu, Amin Ben Hamza, Livius Penter, Xiaojing Chen, Christopher Buccitelli, Oliver Popp, Philipp Mertins, Kerstin Dietze, Lars Bullinger, Andreas Moosmann, Eric Blanc, Dieter Beule, Armin Gerbitz, Julian Strobel, Holger Hackstein, Hans-Peter Rahn, Klaus Dornmair, Thomas Blankenstein, Leo Hansmann

Journal: Cancer Immunol Res

PubMed ID: 36122410

Doi: 10.1158/2326-6066.CIR-22-0434

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Biochemical Identification of a Nuclear Coactivator Protein Required for AtrR-Dependent Gene Regulation in Aspergillus fumigatus

Authors: Sanjoy Paul, Shivani Ror, W Hayes McDonald, W Scott Moye-Rowley

Journal: mSphere

PubMed ID: 36374043

Doi: 10.1128/msphere.00476-22

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A novel humanized Chi3l1 blocking antibody attenuates acetaminophen-induced liver injury in mice

Authors: Leike Li, Yankai Wen, Daniel Wrapp, Jongmin Jeong, Peng Zhao, Wei Xiong, Constance Lynn Atkins, Zhao Shan, Deng Hui, Jason S McLellan, Ningyan Zhang, Cynthia Ju, Zhiqiang An

Journal: Antib Ther

PubMed ID: 36683763

Doi: 10.1093/abt/tbac027

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An odorant receptor that senses four classes of musk compounds

Authors: Keiichi Yoshikawa, Jun Deguchi, Hu Jieying, Hsiu-Yi Lu, Hiroaki Matsunami

Journal: Curr Biol

PubMed ID: 36370695

Doi: 10.1016/j.cub.2022.10.038

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The Integration of Proteome-Wide PTM Data with Protein Structural and Sequence Features Identifies Phosphorylations that Mediate 14-3-3 Interactions

Authors: C M Egbert, L R Warr, K L Pennington, M M Thornton, A J Vaughan, S W Ashworth, M J Heaton, N English, M P Torres, J L Andersen

Journal: J Mol Biol

PubMed ID: 36402225

Doi: 10.1016/j.jmb.2022.167890

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Human histone pre-mRNA assembles histone or canonical mRNA-processing complexes by overlapping 3'-end sequence elements

Authors: Francesco S Ielasi, Sara Ternifi, Emeline Fontaine, Domenico Iuso, Yohann Couté, Andrés Palencia

Journal: Nucleic Acids Res

PubMed ID: 36447390

Doi: 10.1093/nar/gkac878

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Chitosan-functionalized graphene oxide as adjuvant in HEV P239 vaccine

Authors: Qianyu Bai, Zhiwen Wang, Yina An, Jijing Tian, Zhilin Li, Yifei Yang, Yanjun Dong, Mingyong Chen, Tianlong Liu

Journal: Vaccine

PubMed ID: 36371365

Doi: 10.1016/j.vaccine.2022.11.005

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Recent progress in adaptive laboratory evolution of industrial microorganisms

Authors: Guanglu Wang, Qian Li, Zhan Zhang, Xianzhong Yin, Bingyang Wang, Xuepeng Yang

Journal: J Ind Microbiol Biotechnol

PubMed ID: 36323428

Doi: 10.1093/jimb/kuac023

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A KLHL40 3' UTR splice-altering variant causes milder NEM8, an under-appreciated disease mechanism

Authors: Lein N H Dofash, Gavin V Monahan, Emilia Servián-Morilla, Eloy Rivas, Fathimath Faiz, Patricia Sullivan, Emily Oates, Joshua Clayton, Rhonda L Taylor, Mark R Davis, Traude Beilharz, Nigel G Laing, Macarena Cabrera-Serrano, Gianina Ravenscroft

Journal: Hum Mol Genet

PubMed ID: 36322148

Doi: 10.1093/hmg/ddac272

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Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signaling

Authors: Dennis Dik-Long Chau, Wen Li, Wai Wa Ray Chan, Jacquelyne Ka-Li Sun, Yuqi Zhai, Hei-Man Chow, Kwok-Fai Lau

Journal: FASEB J

PubMed ID: 36250347

Doi: 10.1096/fj.202200757R

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Retinal regions shape human and murine Müller cell proteome profile and functionality

Authors: Lew Kaplan, Corinne Drexler, Anna M Pfaller, Santra Brenna, Kirsten A Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M Hauck, Antje Grosche

Journal: Glia

PubMed ID: 36334068

Doi: 10.1002/glia.24283

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Trifluoro-icaritin ameliorates spared nerve injury-induced neuropathic pain by inhibiting microglial activation through α7nAChR-mediated blockade of BDNF/TrkB/KCC2 signaling in the spinal cord of rats

Authors: Dandan Jia, Guangsen Liu, Yalan Sun, Zhiping Hu, Zhihua Huang, Cheng Huang

Journal: Biomed Pharmacother

PubMed ID: 36375307

Doi: 10.1016/j.biopha.2022.114001

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Comprehensive profiling of the human viral exposome in households containing an at-risk child with mitochondrial disease during the 2020-2021 COVID-19 pandemic

Authors: Eliza M Gordon-Lipkin, Christopher S Marcum, Shannon Kruk, Elizabeth Thompson, Sophie E M Kelly, Heather Kalish, Lorenza Bellusci, Surender Khurana, Kaitlyn Sadtler, Peter J McGuire

Journal: Clin Transl Med

PubMed ID: 36336785

Doi: 10.1002/ctm2.1100

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Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway

Authors: Yuyuan Yao, Zhichu Ren, Ruihan Yang, Yilan Mei, Yuying Dai, Qian Cheng, Chong Xu, Xiaogang Xu, Sanying Wang, Kyoung Mi Kim, Ji Heon Noh, Jian Zhu, Ningwei Zhao, Yong U Liu, Genxiang Mao, Jian Sima

Journal: Cell Biosci

PubMed ID: 36333711

Doi: 10.1186/s13578-022-00918-z

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Grafting of short elastin-like peptides using an electric field

Authors: Nuttanit Pramounmat, Sogol Asaei, Jacob D Hostert, Kathleen Young, Horst A von Recum, Julie N Renner

Journal: Sci Rep

PubMed ID: 36333395

Doi: 10.1038/s41598-022-21672-9

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How modular protein nanoparticles may expand the ability of subunit anti-viral vaccines: The spring viremia carp virus (SVCV) case

Authors: Mauricio Rojas, Patricia Aceituno, Maria E Salvador, Marlid Garcia-Ordoñez, Mariana Teles, Maria Del Mar Ortega-Villaizan, Luis Perez, Nerea Roher

Journal: Fish Shellfish Immunol

PubMed ID: 36371050

Doi: 10.1016/j.fsi.2022.10.067

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Alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models

Authors: Thomas Caracena, Rachel Blomberg, Rukshika S Hewawasam, Zoe E Fry, David W H Riches, Chelsea M Magin

Journal: Biomater Sci

PubMed ID: 36366982

Doi: 10.1039/d2bm00827k

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speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing

Authors: Rocío Castellanos-Rueda, Raphaël B Di Roberto, Florian Bieberich, Fabrice S Schlatter, Darya Palianina, Oanh T P Nguyen, Edo Kapetanovic, Heinz Läubli, Andreas Hierlemann, Nina Khanna, Sai T Reddy

Journal: Nat Commun

PubMed ID: 36323661

Doi: 10.1038/s41467-022-34141-8

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Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses

Authors: Ruyu Wang, Guanglei Zhai, Guanghao Zhu, Mengge Wang, Xiaoyi Gong, Weidong Zhang, Guangbo Ge, Hongzhuan Chen, Lili Chen

Journal: Bioorg Chem

PubMed ID: 36395603

Doi: 10.1016/j.bioorg.2022.106264

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Mammalian Target of Rapamycin Inhibition Decreases Angiotensin II-Induced Steroidogenesis in HAC15 Human Adrenocortical Carcinoma Cells

Authors: Yusuf Ali, Elise P Gomez-Sanchez, Celso E Gomez-Sanchez

Journal: Endocrinology

PubMed ID: 36320101

Doi: 10.1210/endocr/bqac185

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Broad-specificity indirect competitive enzyme-linked immunosorbent assay for aristolochic acids: Computer-aided hapten design and molecular mechanism of antibody recognition

Authors: Xiaonan Wang, Qingpeng Lu, Leina Dou, Minggang Liu, Peipei Li, Wenbo Yu, Xuezhi Yu, Zhanhui Wang, Kai Wen

Journal: Sci Total Environ

PubMed ID: 36347294

Doi: 10.1016/j.scitotenv.2022.159941

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New Effective Method of Lactococcus Genome Editing Using Guide RNA-Directed Transposition

Authors: Pavel Yu Pechenov, Danil A Garagulya, Daniil S Stanovov, Andrey V Letarov

Journal: Int J Mol Sci

PubMed ID: 36430465

Doi: 10.3390/ijms232213978

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Linoleic acid binds to SARS-CoV-2 RdRp and represses replication of seasonal human coronavirus OC43

Authors: Anna Goc, Waldemar Sumera, Matthias Rath, Aleksandra Niedzwiecki

Journal: Sci Rep

PubMed ID: 36352079

Doi: 10.1038/s41598-022-23880-9

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Alginate-Chitosan Hydrogel Formulations Sustain Baculovirus Delivery and VEGFA Expression Which Promotes Angiogenesis for Wound Dressing Applications

Authors: Sabrina Schaly, Paromita Islam, Ahmed Abosalha, Jacqueline L Boyajian, Dominique Shum-Tim, Satya Prakash

Journal: Pharmaceuticals (Basel)

PubMed ID: 36355553

Doi: 10.3390/ph15111382

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PNGase H + variant from Rudaea cellulosilytica with improved deglycosylation efficiency for rapid analysis of eukaryotic N-glycans and hydrogen deuterium exchange mass spectrometry analysis of glycoproteins

Authors: Rui-Rui Guo, Tian-Chan Zhang, Thomas Ole Tandrup Lambert, Ting Wang, Josef Voglmeir, Kasper D Rand, Li Liu

Journal: Rapid Commun Mass Spectrom

PubMed ID: 35945033

Doi: 10.1002/rcm.9376

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The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice

Authors: Karianne Fjeld, Anny Gravdal, Ranveig S Brekke, Jahedul Alam, Steven J Wilhelm, Khadija El Jellas, Helene N Pettersen, Jianguo Lin, Marie H Solheim, Solrun J Steine, Bente B Johansson, Pål R Njølstad, Caroline S Verbeke, Xunjun Xiao, Mark E Lowe, Anders Molven

Journal: Pancreatology

PubMed ID: 36379850

Doi: 10.1016/j.pan.2022.11.003

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Immune responses of hemocytes in the blood clam Tegillarca granosa in response to in vivo Vibrio harveyi infection

Authors: Qianyuan Yang, Guoqiang Xiao, Ran Chen, Xiaolin Huang, Shuangshuang Teng

Journal: Fish Shellfish Immunol

PubMed ID: 36435369

Doi: 10.1016/j.fsi.2022.11.035

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Seroepidemiological and genomic investigation of SARS-CoV-2 spread in North East region of India

Authors: Romi Wahengbam, Pankaj Bharali, Prasenjit Manna, Tridip Phukan, Moirangthem Goutam Singh, Gayatri Gogoi, Yasmin Begam Tapadar, Anil Kumar Singh, Rituraj Konwar, Channakeshavaiah Chikkaputtaiah, Natarajan Velmurugan, Selvaraman Nagamani, Hridoy Jyoti Mahanta, Himakshi Sarma, Ravi Kumar Sahu, Prachurjya Dutta, Sawlang Borsingh Wann, Jatin Kalita, G Narahari Sastry

Journal: Indian J Med Microbiol

PubMed ID: 36371334

Doi: 10.1016/j.ijmmb.2022.10.011

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SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1

Authors: Di Wang, Weiwei Liang, Di Huo, Hongyong Wang, Ying Wang, Chaohua Cong, Chunting Zhang, Shi Yan, Ming Gao, Xiaoli Su, Xingli Tan, Wenmo Zhang, Ling Han, Dongmei Zhang, Honglin Feng

Journal: Cell Death Differ

PubMed ID: 36443440

Doi: 10.1038/s41418-022-01089-7

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PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1

Authors: Yuzhong Chen, Wanqing Liang, Jun Du, Jiachi Ma, Rongrui Liang, Min Tao

Journal: Exp Cell Res

PubMed ID: 36400182

Doi: 10.1016/j.yexcr.2022.113413

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TMBIM5 is the Ca /H antiporter of mammalian mitochondria

Authors: Shane Austin, Ronald Mekis, Sami E M Mohammed, Mariafrancesca Scalise, Wen-An Wang, Michele Galluccio, Christina Pfeiffer, Tamara Borovec, Katja Parapatics, Dijana Vitko, Nora Dinhopl, Nicolas Demaurex, Keiryn L Bennett, Cesare Indiveri, Karin Nowikovsky

Journal: EMBO Rep

PubMed ID: 36321428

Doi: 10.15252/embr.202254978

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Heat shock protein 20 suppresses breast carcinogenesis by inhibiting the MAPK and AKT signaling pathways

Authors: Yinxi Yang, Yifeng Wu, Lihong Hou, Xin Ge, Guoquan Song, Hongdou Jin

Journal: Oncol Lett

PubMed ID: 36380873

Doi: 10.3892/ol.2022.13582

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Prevalence of Neospora caninum, Toxoplasma gondii and Brucella abortus in water buffalo (Bubalus bubalis): Climatic and environmental risk factors in eastern and southeast Mexico

Authors: J Baltazar-Pérez, F Utrera-Quintana, J Camacho-Ronquillo, R González-Garduño, H Jiménez-Cortez, A Villa-Mancera

Journal: Microb Pathog

PubMed ID: 36356791

Doi: 10.1016/j.micpath.2022.105871

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In silico analysis of a novel protein in CAR T- cell therapy for the treatment of hematologic cancer through molecular modelling, docking, and dynamics approach

Authors: Rimjhim Mohanty, Manoswini Manoswini, Ajit Kumar Dhal, Niladri Ganguly

Journal: Comput Biol Med

PubMed ID: 36395593

Doi: 10.1016/j.compbiomed.2022.106285

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