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Delineation of the CYP505E subfamily of fungal self-sufficient in-chain hydroxylating cytochrome P450 monooxygenases

Authors: Martha Sophia Smit, Mpeyake Jacob Maseme, Jacqueline van Marwijk, Jasmin Cara Aschenbrenner, Diederik Johannes Opperman

Journal: Appl Microbiol Biotechnol

PubMed ID: 36607403

Doi: 10.1007/s00253-022-12329-8

Products & Services: Molecular Biology Reagents

Dwarf Open Reading Frame (DWORF) Gene Therapy Ameliorated Duchenne Muscular Dystrophy Cardiomyopathy in Aged mdx Mice

Authors: Emily D Morales, Yongping Yue, Thais B Watkins, Jin Han, Xiufang Pan, Aaron M Gibson, Bryan Hu, Omar Brito-Estrada, Gang Yao, Catherine A Makarewich, Gopal J Babu, Dongsheng Duan

Journal: J Am Heart Assoc

PubMed ID: 36695318

Doi: 10.1161/JAHA.122.027480

Products & Services: Molecular Biology Reagents

A covalent opsonization approach to enhance synthetic immunity against viral escape variants

Authors: Eden Kapcan, Anthony F Rullo

Journal: Cell Rep Phys Sci

PubMed ID: 36741337

Doi: 10.1016/j.xcrp.2023.101258

Products & Services: Molecular Biology Reagents

Identification of gluten T cell epitopes driving celiac disease

Authors: Markéta Chlubnová, Asbjørn O Christophersen, Geir Kjetil F Sandve, Knut E A Lundin, Jørgen Jahnsen, Shiva Dahal-Koirala, Ludvig M Sollid

Journal: Sci Adv

PubMed ID: 36696493

Doi: 10.1126/sciadv.ade5800

Products & Services: Peptide Synthesis

The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9

Authors: Charles Bayly-Jones, Bill H T Ho, Corinna Lau, Eleanor W W Leung, Laura D'Andrea, Christopher J Lupton, Susan M Ekkel, Hariprasad Venugopal, James C Whisstock, Tom E Mollnes, Bradley A Spicer, Michelle A Dunstone

Journal: Commun Biol

PubMed ID: 36639734

Doi: 10.1038/s42003-023-04431-y

Products & Services: DNA Sequencing

Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters

Authors: Bart Nieuwenhuis, Elise Laperrousaz, James R Tribble, Joost Verhaagen, James W Fawcett, Keith R Martin, Pete A Williams, Andrew Osborne

Journal: Gene Ther

PubMed ID: 36635457

Doi: 10.1038/s41434-022-00380-z

Products & Services: Plasmid DNA Preparation

Highly efficient and robust π-FISH rainbow for multiplexed in situ detection of diverse biomolecules

Authors: Yingfeng Tao, Xiaoliu Zhou, Leqiang Sun, Da Lin, Huaiyuan Cai, Xi Chen, Wei Zhou, Bing Yang, Zhe Hu, Jing Yu, Jing Zhang, Xiaoqing Yang, Fang Yang, Bang Shen, Wenbao Qi, Zhenfang Fu, Jinxia Dai, Gang Cao

Journal: Nat Commun

PubMed ID: 36707540

Doi: 10.1038/s41467-023-36137-4

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Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium

Authors: Heather M Callaway, Kathryn M Hastie, Sharon L Schendel, Haoyang Li, Xiaoying Yu, Jeremy Shek, Tierra Buck, Sean Hui, Dan Bedinger, Camille Troup, S Moses Dennison, Kan Li, Michael D Alpert, Charles C Bailey, Sharon Benzeno, Jody L Bonnevier, Jin-Qiu Chen, Charm Chen, Hyeseon Cho, Peter D Crompton, Vincent Dussupt, Kevin C Entzminger, Yassine Ezzyat, Jonathan K Fleming, Nick Geukens, Amy E Gilbert, Yongjun Guan, Xiaojian Han, Christopher J Harvey, Julia M Hatler, Bryan Howie, Chao Hu, Ailong Huang, Maya Imbrechts, Aishun Jin, Nik Kamachi, Gladys Keitany, Mark Klinger, Jay K Kolls, Shelly J Krebs, Tingting Li, Feiyan Luo, Toshiaki Maruyama, Michael A Meehl, Letzibeth Mendez-Rivera, Andrea Musa, C J Okumura, Benjamin E R Rubin, Aaron K Sato, Meiying Shen, Anirudh Singh, Shuyi Song, Joshua Tan, Jeffrey M Trimarchi, Dhruvkumar P Upadhyay, Yingming Wang, Lei Yu, Tom Z Yuan, Erik Yusko, Bjoern Peters, Georgia Tomaras, Erica Ollmann Saphire

Journal: Cell Rep

PubMed ID: 36681898

Doi: 10.1016/j.celrep.2023.112014

Products & Services: Molecular Biology Reagents

Author Correction: Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376

Authors: Xiao-Dong Luan, Bin-Xian Chen, Wei-Juan Shang, Wan-Chao Yin, Ye Jin, Lei-Ke Zhang, H Eric Xu, Shu-Yang Zhang

Journal: Acta Pharmacol Sin

PubMed ID: 35948753

Doi: 10.1038/s41401-022-00964-w

Products & Services: Proteins, Expression, Isolation and Analysis

The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer

Authors: Xue Yang, Miguel I Cruz, Elizabeth V Nguyen, Cheng Huang, Ralf B Schittenhelm, Jennii Luu, Karla J Cowley, Sung-Young Shin, Lan K Nguyen, Terry C C Lim Kam Sian, Kimberley C Clark, Kaylene J Simpson, Xiuquan Ma, Roger J Daly

Journal: Oncogene

PubMed ID: 36693952

Doi: 10.1038/s41388-023-02594-w

Products & Services: Proteins, Expression, Isolation and Analysis

Booster shot of inactivated SARS-CoV-2 vaccine induces potent immune responses in people living with HIV

Authors: Haoting Zhan, Huixia Gao, Yongmei Liu, Xihong Zhang, Haolong Li, Xiaomeng Li, Lijing Wang, Chen Li, Beilei Li, Yuling Wang, Erhei Dai, Yongzhe Li

Journal: J Med Virol

PubMed ID: 36571267

Doi: 10.1002/jmv.28428

Products & Services: Proteins, Expression, Isolation and Analysis

Structural Basis for Self-Discrimination by Neoantigen-Specific TCRs

Authors: John P Finnigan, Jenna H Newman, Yury Patskovsky, Larysa Patskovska, Andrew S Ishizuka, Geoffrey M Lynn, Robert A Seder, Michelle Krogsgaard, Nina Bhardwaj

Journal: Res Sq

PubMed ID: 36778273

Doi: 10.21203/rs.3.rs-2531184/v1

Products & Services: Proteins, Expression, Isolation and Analysis

Alleviation of Hepatic Steatosis by 4-azidophlorizin via the Degradation of Geranylgeranyl Diphosphate Synthase by the Ubiquitin-Proteasome Pathway in Vivo and in Vitro

Authors: Juan Ye, Yaling Qi, Jiao Chen, Shihu Zhang, Boyuan Liu, Yinjuan Zhao, Xianwen Yuan, Qi Cheng, Yang Yang, Furong Zhang, Hongliang Gao, Haoran Wang, Jing Wu, Feng Zhu, Chaojun Li, Peng Cao, Bin Xue

Journal: Adv Biol (Weinh)

PubMed ID: 36599632

Doi: 10.1002/adbi.202200150

Products & Services: Proteins, Expression, Isolation and Analysis

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus

Authors: Jennifer A Jenks, Sharmi Amin, Madeline R Sponholtz, Amit Kumar, Daniel Wrapp, Sravani Venkatayogi, Joshua J Tu, Krithika Karthigeyan, Sarah M Valencia, Megan Connors, Melissa J Harnois, Bhavna Hora, Eric Rochat, Jason S McLellan, Kevin Wiehe, Sallie R Permar

Journal: PLoS Pathog

PubMed ID: 36662906

Doi: 10.1371/journal.ppat.1011107

Products & Services: Recombinant Antibody Expression

An OsPRMT5-OsAGO2/miR1875-OsHXK1 module regulates rice immunity to blast disease

Authors: Cong Sheng, Xuan Li, Shengge Xia, Yimai Zhang, Ze Yu, Cheng Tang, Le Xu, Zhaoyun Wang, Xin Zhang, Tong Zhou, Pingping Nie, Ayesha Baig, Dongdong Niu, Hongwei Zhao

Journal: J Integr Plant Biol

PubMed ID: 36511124

Doi: 10.1111/jipb.13430

Products & Services: Proteins, Expression, Isolation and Analysis

Performance evaluation of the Ortho VITROS SARS-CoV-2 Spike-Specific Quantitative IgG test by comparison with the surrogate virus neutralizing antibody test and clinical assessment

Authors: Maika Takahashi, Kaori Saito, Tomohiko Ai, Shuko Nojiri, Abdullah Khasawneh, Faith Jessica Paran, Yuki Horiuchi, Satomi Takei, Takamasa Yamamoto, Mitsuru Wakita, Makoto Hiki, Takashi Miida, Toshio Naito, Kazuhisa Takahashi, Yoko Tabe

Journal: PLoS ONE

PubMed ID: 36693058

Doi: 10.1371/journal.pone.0279779

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Structural domains of SARS-CoV-2 nucleocapsid protein coordinate to compact long nucleic acid substrates

Authors: Michael Morse, Jana Sefcikova, Ioulia Rouzina, Penny J Beuning, Mark C Williams

Journal: Nucleic Acids Res

PubMed ID: 36533523

Doi: 10.1093/nar/gkac1179

Products & Services: Recombinant Proteins

S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction

Authors: Liam Butler , Carolina Locatelli , Despoina Allagioti , Irina Lousa , Kimon Lemonidis , Nicholas C O Tomkinson , Christine Salaun , Luke H Chamberlain

Journal: J Biol Chem

PubMed ID: 36442513

Doi: 10.1016/j.jbc.2022.102754

Products & Services: Mutagenesis Services ORF cDNA Clones/MolecularCloud

Functional Impact of a Cancer-Related Variant in Human Δ1-Pyrroline-5-Carboxylate Reductase 1

Authors: Oseeyi I Daudu , Kaylen R Meeks , Lu Zhang , Javier Seravalli , John J Tanner , Donald F Becker

Journal: ACS Omega .

PubMed ID: 36713721

Doi: 10.1021/acsomega.2c07788

Products & Services: Mutagenesis Services

Enhancer architecture and chromatin accessibility constrain phenotypic space during Drosophila development

Authors: Rafael Galupa, Gilberto Alvarez-Canale, Noa Ottilie Borst, Timothy Fuqua, Lautaro Gandara, Natalia Misunou, Kerstin Richter, Mariana R P Alves, Esther Karumbi, Melinda Liu Perkins, Tin Kocjan, Christine A Rushlow, Justin Crocker

Journal: Dev Cell

PubMed ID: 36626871

Doi: 10.1016/j.devcel.2022.12.003

Products & Services: Molecular Biology Reagents Gene Synthesis

YAP1 suppression inhibits autophagy and improves the efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma

Authors: Yuting Gao, Qing Peng, Shenghao Li, Kangning Zheng, Yi Gong, Yu Xue, Yiwei Liu, Junlan Lu, Yuman Zhang, Xinli Shi

Journal: Exp Cell Res

PubMed ID: 36693491

Doi: 10.1016/j.yexcr.2023.113486

Products & Services: Proteins, Expression, Isolation and Analysis

An iterative gene-editing strategy broadens eIF4E1 genetic diversity in Solanum lycopersicum and generates resistance to multiple potyvirus isolates

Authors: Kyoka Kuroiwa, Benoit Danilo, Laura Perrot, Christina Thenault, Florian Veillet, Fabien Delacote, Philippe Duchateau, Fabien Nogué, Marianne Mazier, Jean-Luc Gallois

Journal: Plant Biotechnol J

PubMed ID: 36715107

Doi: 10.1111/pbi.14003

Products & Services: Proteins, Expression, Isolation and Analysis

Human mitochondria require mtRF1 for translation termination at non-canonical stop codons

Authors: Annika Krüger, Cristina Remes, Dmitrii Igorevich Shiriaev, Yong Liu, Henrik Spåhr, Rolf Wibom, Ilian Atanassov, Minh Duc Nguyen, Barry S Cooperman, Joanna Rorbach

Journal: Nat Commun

PubMed ID: 36596788

Doi: 10.1038/s41467-022-35684-6

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New Synthetic Operon Vectors for Expressing Multiple Proteins in the Chloroplast

Authors: Jihye Yeon, Stephen M Miller, Wipawee Dejtisakdi

Journal: Genes (Basel)

PubMed ID: 36833295

Doi: 10.3390/genes14020368

Products & Services: Molecular Biology Reagents

Epitope identification for p53R273C mutant

Authors: Jian Zhang, Minglu Liu, Yin Chen, Zishan Zhou, Ping Wang, Yang Yu, Shunchang Jiao

Journal: Immun Inflamm Dis

PubMed ID: 36705409

Doi: 10.1002/iid3.752

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A Search for Tick-Associated, Bronnoya-like Virus Spillover into Sheep

Authors: Bianca Elena Bratuleanu, Cristian Raileanu, Delphine Chrétien, Pablo Guardado-Calvo, Thomas Bigot, Gheorghe Savuta, Sarah Temmam, Marc Eloit

Journal: Microorganisms

PubMed ID: 36677501

Doi: 10.3390/microorganisms11010209

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Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex

Authors: Zhicheng Cui, Gennaro Napolitano, Mariana E G de Araujo, Alessandra Esposito, Jlenia Monfregola, Lukas A Huber, Andrea Ballabio, James H Hurley

Journal: Nature

PubMed ID: 36697823

Doi: 10.1038/s41586-022-05652-7

Products & Services: Codon Optimization

Ensemble-based, high-throughput virtual screening of potential inhibitor targeting putative farnesol dehydrogenase of Metisa plana (Lepidoptera: Psychidae)

Authors: Anis Nadyra Zifruddin, Mohamad Ariff Mohamad Yusoff, Nur Syatila Abd Ghani, Nor Azlan Nor Muhammad, Kok Wai Lam, Maizom Hassan

Journal: Comput Biol Chem

PubMed ID: 36645937

Doi: 10.1016/j.compbiolchem.2023.107811

Products & Services: DNA Sequencing

A novel secreted protein, NISP1, is phosphorylated by soybean Nodulation Receptor Kinase to promote nodule symbiosis

Authors: Baolan Fu, Zhipeng Xu, Yutao Lei, Ru Dong, Yanan Wang, Xiaoli Guo, Hui Zhu, Yangrong Cao, Zhe Yan

Journal: J Integr Plant Biol

PubMed ID: 36534458

Doi: 10.1111/jipb.13436

Products & Services: Recombinant Proteins

A soluble TLR5 is involved in PBLs activation and antibacterial immunity via TLR5M-MyD88-signaling pathway in tongue sole Cynoglossus semilaevis

Authors: Ji-Xing Feng, Ling Liu, Hong-Ye Wang, Jian Zhang, Xue-Peng Li

Journal: Int J Biol Macromol

PubMed ID: 36634796

Doi: 10.1016/j.ijbiomac.2023.123208

Products & Services: Proteins, Expression, Isolation and Analysis

Diagnostic performance between in-house and commercial SARS-CoV-2 serological immunoassays including binding-specific antibody and surrogate virus neutralization test (sVNT)

Authors: Poramed Winichakoon, Jiraprapa Wipasa, Kriangkrai Chawansuntati, Parichat Salee, Tavitiya Sudjaritruk, Saowaluck Yasri, Chantana Khamwan, Rungnapa Peerakam, Dararat Dankai, Romanee Chaiwarith

Journal: Sci Rep

PubMed ID: 36593231

Doi: 10.1038/s41598-022-26202-1

Products & Services: Proteins, Expression, Isolation and Analysis

Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis

Authors: Wencheng Zhu, Huiying Chu, Yajuan Zhang, Tianhang Luo, Hua Yu, Hongwen Zhu, Ye Liu, Hong Gao, Yun Zhao, Quanlin Li, Xiongjun Wang, Guohui Li, Weiwei Yang

Journal: Cell Res

PubMed ID: 36646759

Doi: 10.1038/s41422-022-00773-0

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Chimeric a-subunit isoforms generate functional yeast V-ATPases with altered regulatory properties in vitro and in vivo

Authors: Farzana Tuli, Patricia M Kane

Journal: Mol Biol Cell

PubMed ID: 36598799

Doi: 10.1091/mbc.E22-07-0265

Products & Services: Molecular Biology Reagents

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

Authors: View ORCID ProfileMartin S. Taylor, Connie Wu, Peter C. Fridy, Yasmeen Senussi, Wen-Chih Cheng, John Heaps, Kei Mori, Limor Cohen, Kelly R. Molloy, Brian T. Chait, Michael Goggins, Irun Bhan, Joseph W. Franses, Xiaoyu Yang, Mary-Ellen Taplin, Xinan Wang, David C. Christiani, Bruce E. Johnson, Matthew Meyerson, Ravindra Uppaluri, Ann Marie Egloff, Elyssa N. Denault, Laura M. Spring, Tian-Li Wang, Ie-Ming Shih, Euihye Jung, Kshitij S. Arora, Lawrence R. Zukerberg, Osman H. Yilmaz, Gary Chi, Bryanna L. Norden, Yuhui Song, Linda Nieman, Aparna R. Parikh, Matthew Strickland, Tomas Mustelin, George Eng, Ömer H. Yilmaz, Ursula A. Matulonis, Steven J. Skates, Bo R. Rueda, Ronny Drapkin, Samuel J. Klempner, Vikram Deshpande, David T. Ting, Michael P. Rout, John LaCava, View ORCID ProfileDavid R. Walt, View ORCID ProfileKathleen H. Burns

Journal: biorxiv

Doi: 10.1101/2023.01.25.525462

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Development of a Competitive Enzyme-Linked Immunosorbent Assay Targeting the-p30 Protein for Detection of Antibodies against African Swine Fever Virus

Authors: Junming Zhou, Yanxiu Ni, Dandan Wang, Baochao Fan, Xuejiao Zhu, Jinzhu Zhou, Yiyi Hu, Li Li, Bin Li

Journal: Viruses

PubMed ID: 36680193

Doi: 10.3390/v15010154

Products & Services: Proteins, Expression, Isolation and Analysis

Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma

Authors: Wajd N Al-Holou, Hanxiao Wang, Visweswaran Ravikumar, Sunita Shankar, Morgan Oneka, Ziad Fehmi, Roel Gw Verhaak, Hoon Kim, Drew Pratt, Sandra Camelo-Piragua, Corey Speers, Daniel R Wahl, Todd Hollon, Oren Sagher, Jason A Heth, Karin M Muraszko, Theodore S Lawrence, Ana C de Carvalho, Tom Mikkelsen, Arvind Rao, Alnawaz Rehemtulla

Journal: Neoplasia

PubMed ID: 36621024

Doi: 10.1016/j.neo.2022.100872

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ABT1 modifies SMARD1 pathology via interactions with IGHMBP2 and stimulation of ATPase and helicase activity

Authors: Gangadhar P Vadla, Sara M Ricardez Hernandez, Jiude Mao, Mona O Garro-Kacher, Zachary C Lorson, Ronin P Rice, Sarah A Hansen, Christian L Lorson, Kamal Singh, Monique A Lorson

Journal: JCI Insight

PubMed ID: 36480289

Doi: 10.1172/jci.insight.164608

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Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate

Authors: Weam S Shahin, Shima O Ebed, Scott R Tyler, Branko Miljkovic, Soon H Choi, Yulong Zhang, Weihong Zhou, Idil A Evans, Charles Yeaman, John F Engelhardt

Journal: Nat Commun

PubMed ID: 36707536

Doi: 10.1038/s41467-023-36174-z

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CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX

Authors: Jack T Whelan, Ragunath Singaravelu, Fuan Wang, Adrian Pelin, Levi A Tamming, Giuseppe Pugliese, Nikolas T Martin, Mathieu J F Crupi, Julia Petryk, Bradley Austin, Xiaohong He, Ricardo Marius, Jessie Duong, Carter Jones, Emily E F Fekete, Nouf Alluqmani, Andrew Chen, Stephen Boulton, Michael S Huh, Matt Y Tang, Zaid Taha, Elena Scut, Jean-Simon Diallo, Taha Azad, Brian D Lichty, Carolina S Ilkow, John C Bell

Journal: Front Immunol

PubMed ID: 36713447

Doi: 10.3389/fimmu.2022.1050250

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Generation of RUNX1c-eGFP induced pluripotent stem cell, MUSIi012-A-4, using CRISPR/Cas9

Authors: Pimonwan Srisook, Chuti Laowtammathron, Chanchao Lorthongpanich, Phatchanat Klaihmon, Papussorn Terbto, Supaporn Waeteekul, Yaowalak U-Pratya, Surapol Issaragrisil

Journal: Stem Cell Res

PubMed ID: 36753833

Doi: 10.1016/j.scr.2023.103035

Products & Services: Gene Synthesis

Changes in Gene Chromatin Organization during Odontogenic Lineage Specification

Authors: Gokul Gopinathan, Xinmin Zhang, Xianghong Luan, Thomas G H Diekwisch

Journal: Genes (Basel)

PubMed ID: 36672939

Doi: 10.3390/genes14010198

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BML-111, the agonist of lipoxin A4, suppresses epithelial-mesenchymal transition and migration of MCF-7 cells regulating the lipoxygenase pathway

Authors: Fen Xu, Xiaoyan Zhou, Lan Lin, Jing Xu, Yu Feng, Yuanqiao He, Hua Hao

Journal: Int J Immunopathol Pharmacol

PubMed ID: 38134963

Doi: 10.1177/03946320231223826

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SaaS sRNA promotes Salmonella intestinal invasion via modulating MAPK inflammatory pathway

Authors: Linlin Cai , Yunting Xie , Liangting Shao , Haijing Hu , Xinglian Xu , Huhu Wang , Guanghong Zhou

Journal: Gut Microbes .

PubMed ID: 37158502

Doi: 10.1080/19490976.2023.2211184

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Genetic diversity of Newcastle disease viruses circulating in wild and synanthropic birds in Ukraine between 2006 and 2015

Authors: Iryna V Goraichuk, Anton Gerilovych, Vitaliy Bolotin, Olexii Solodiankin, Kiril M Dimitrov, Oleksandr Rula, Nataliia Muzyka, Oleksandr Mezinov, Borys Stegniy, Olena Kolesnyk, Mary J Pantin-Jackwood, Patti J Miller, Claudio L Afonso, Denys Muzyka

Journal: Front Vet Sci

PubMed ID: 36742982

Doi: 10.3389/fvets.2023.1026296

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Nanoparticle vaccines can be designed to induce pDC support of mDCs for increased antigen display

Authors: Nina Butkovich, Jo Anne Tucker, Aaron Ramirez, Enya Li, Vijaykumar S Meli, Edward L Nelson, Szu-Wen Wang

Journal: Biomater Sci

PubMed ID: 36476811

Doi: 10.1039/d2bm01132h

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Potential Protective Function of Aβ Monomer on Tauopathies

Authors: Amber L H Gray, Victoria Norman, Damilola S Oluwatoba, Rebecca A Prosser, Thanh D Do

Journal: J Am Soc Mass Spectrom

PubMed ID: 36693165

Doi: 10.1021/jasms.2c00343

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MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcoma

Authors: Laura S Danielson, Maria V Guijarro, Silvia Menendez, Brett Higgins, Qiang Sun, Khushbakhat Mittal, Dorota A Popiolek, Michael Overholtzer, Glyn D Palmer, Eva Hernando

Journal: PLoS ONE

PubMed ID: 36701370

Doi: 10.1371/journal.pone.0278844

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Differentially Expressed Genes and Signalling Pathways Regulated by High Selenium Involved in Antioxidant and Immune Functions of Goats Based on Transcriptome Sequencing

Authors: Xu Wang, Chao Ban, Jia-Xuan Li, Qing-Yuan Luo, Ji-Xiao Qin, Yi-Qing Xu, Qi Lu, Xing-Zhou Tian

Journal: Int J Mol Sci

PubMed ID: 36674636

Doi: 10.3390/ijms24021124

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Ligand-dependent protein interactions of the juvenile hormone receptor captured in real time

Authors: Sarka Tumova, Marek Jindra

Journal: FEBS J

PubMed ID: 36609881

Doi: 10.1111/febs.16719

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Discovery and validation of new Hv1 proton channel inhibitors with onco-therapeutic potential

Authors: Antoun El Chemaly, Vincent Jaquet, Yves Cambet, Aurélie Caillon, Ophélie Cherpin, Alexia Balafa, Karl-Heinz Krause, Nicolas Demaurex

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 36640925

Doi: 10.1016/j.bbamcr.2022.119415

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His-tagged lactate oxidase production for industrial applications using fed-batch fermentation

Authors: Agustina Godino, Marilla Amaranto, Agustina Manassero, Fausto Comba, Martín Alonzo Pérez, Lucio Simonella, Martín Pernigotti, José L Barra

Journal: J Biotechnol

PubMed ID: 36608873

Doi: 10.1016/j.jbiotec.2022.12.011

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Protective Effects of against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles

Authors: Tianhua He, Nikita Lykov, Xu Luo, Huiling Wang, Zhanxiang Du, Ziyi Chen, Shitian Chen, Lin Zhu, Ye Zhao, Chimeng Tzeng

Journal: Int J Mol Sci

PubMed ID: 36768377

Doi: 10.3390/ijms24032053

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Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation

Authors: Pedro Madrigal, Siwei Deng, Yuliang Feng, Stefania Militi, Kim Jee Goh, Reshma Nibhani, Rodrigo Grandy, Anna Osnato, Daniel Ortmann, Stephanie Brown, Siim Pauklin

Journal: Nat Commun

PubMed ID: 36697417

Doi: 10.1038/s41467-023-36116-9

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Hyaluronate decorated polyethylene glycol linked poly(lactide-co-glycolide) nanoparticles encapsulating MUC-1 peptide augmented mucosal immune response in Balb/c mice through inhalation route

Authors: Kiran Jyoti, Garima Malik, Monika Chaudhary, Jitender Madan, Anjoo Kamboj

Journal: Biochim Biophys Acta Gen Subj

PubMed ID: 36731729

Doi: 10.1016/j.bbagen.2023.130317

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Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates

Authors: Yuanyuan Zhang, Xinyu Zhao, Xiaona Dong, Yuying Zhang, Haixia Zou, Yaoguang Jin, Wei Guo, Peng Zhai, Xu Chen, Alexei Kharitonenkov

Journal: Cell Metab

PubMed ID: 36706758

Doi: 10.1016/j.cmet.2023.01.001

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Comparative analysis of allergenicity and predicted linear epitopes in α and β parvalbumin from turbot (Scophthalmus maximus)

Authors: Yuhao Huang, Zhenxing Li, Yeting Wu, Yonghong Li, Siddanakoppalu Pramod, Guanzhi Chen, Wenjia Zhu, Ziye Zhang, Hao Wang, Hong Lin

Journal: J Sci Food Agric

PubMed ID: 36606403

Doi: 10.1002/jsfa.12432

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Oncogenic KRAS signaling drives evasion of innate immune surveillance in lung adenocarcinoma by activating CD47

Authors: Huanhuan Hu, Rongjie Cheng, Yanbo Wang, Xiaojun Wang, Jianzhuang Wu, Yan Kong, Shoubin Zhan, Zhen Zhou, Hongyu Zhu, Ranran Yu, Gaoli Liang, Qingyan Wang, Xiaoju Zhu, Chen-Yu Zhang, Rong Yin, Chao Yan , Xi Chen

Journal: The Journal of Clinical Investigation

PubMed ID: 36413402

Doi: 10.1172/JCI153470

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Cytochalasin B-Induced Membrane Vesicles from TRAIL-Overexpressing Mesenchymal Stem Cells Induce Extrinsic Pathway of Apoptosis in Breast Cancer Mouse Model

Authors: Daria S Chulpanova , Tamara V Pukhalskaia , Zarema E Gilazieva , Yuliya V Filina 1, Milana N Mansurova 1, Albert A Rizvanov 1, Valeriya V Solovyeva

Journal: Curr Issues Mol Biol .

PubMed ID: 36661524

Doi: 10.3390/cimb45010038

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α-Synuclein as a Target for Metallo-Anti-Neurodegenerative Agents

Authors: Kaiming Cao , Yang Zhu , Zhuanghao Hou , Manman Liu , Yanyan Yang , Hongze Hu , Yi Dai , Yu Wang , Siming Yuan , Guangming Huang , Jiaming Mei , Peter J Sadler , Yangzhong Liu

Journal: Angew Chem Int Ed Engl .

PubMed ID: 36345707

Doi: 10.1002/anie.202215360

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Click and bioorthogonal hyaluronic acid hydrogels as an ultra-tunable platform for the investigation of cell-material interactions

Authors: Nathan Lagneau, Pierre Tournier, Boris Halgand, François Loll, Yves Maugars, Jérôme Guicheux, Catherine Le Visage, Vianney Delplace

Journal: Bioact Mater

PubMed ID: 36632500

Doi: 10.1016/j.bioactmat.2022.12.022

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The establishment of multiple knockout mutants of Colletotrichum orbiculare by CRISPR-Cas9 and Cre-loxP systems

Authors: Kohji Yamada, Toya Yamamoto, Kanon Uwasa, Keishi Osakabe, Yoshitaka Takano

Journal: Fungal Genet Biol

PubMed ID: 36669556

Doi: 10.1016/j.fgb.2023.103777

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Association Between Human Immunodeficiency Virus Viremia and Compromised Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Beta Variant

Authors: Shi-Hsia Hwa, Jumari Snyman, Mallory Bernstein, Yashica Ganga, Sandile Cele, Daniel Muema, Chee Wah Tan, Khadija Khan, Farina Karim, Willem Hanekom, Leslie Bernstein, Stefan H E Kaufmann, Lin-Fa Wang, Thumbi Ndung'u, Alex Sigal

Journal: J Infect Dis

PubMed ID: 35975942

Doi: 10.1093/infdis/jiac343

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The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma

Authors: Yue Yan, Marc-Andre Gauthier, Ahmad Malik, Iosifina Fotiadou, Michael Ostrovski, Dzana Dervovic, Logine Ghadban, Ricky Tsai, Gerald Gish, Sampath Kumar Loganathan, Daniel Schramek

Journal: Cancers (Basel)

PubMed ID: 36765696

Doi: 10.3390/cancers15030737

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SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression

Authors: Laura Cioetto-Mazzabò, Francesca Boldrin, Claire Beauvineau, Martin Speth, Alberto Marina, Amine Namouchi, Greta Segafreddo, Mena Cimino, Sandrine Favre-Rochex, Seetha Balasingham, Beatriz Trastoy, Hélène Munier-Lehmann, Gareth Griffiths, Brigitte Gicquel, Marcelo E Guerin, Riccardo Manganelli, Noelia Alonso-Rodríguez

Journal: Nucleic Acids Res

PubMed ID: 36546765

Doi: 10.1093/nar/gkac1173

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The FACT-targeted drug CBL0137 enhances the effects of rituximab to inhibit B-cell non-Hodgkin's lymphoma tumor growth by promoting apoptosis and autophagy

Authors: Yan Lv, Yuxin Du, Kening Li, Xiao Ma, Juan Wang, Tongde Du, Yuxin Ma, Yue Teng, Weiyan Tang, Rong Ma, Jianqiu Wu, Jianzhong Wu, Jifeng Feng

Journal: Cell Commun Signal

PubMed ID: 36691066

Doi: 10.1186/s12964-022-01031-x

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Plant production of a virus-like particle-based vaccine candidate against porcine reproductive and respiratory syndrome

Authors: Jordan T VanderBurgt, Ondre Harper, Christopher P Garnham, Susanne E Kohalmi, Rima Menassa

Journal: Front Plant Sci

PubMed ID: 36760639

Doi: 10.3389/fpls.2023.1044675

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Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs

Authors: Yuki Ono, Kouki Kawakami, Gaku Nakamura, Satoru Ishida, Junken Aoki, Asuka Inoue

Journal: Commun Biol

PubMed ID: 36709222

Doi: 10.1038/s42003-023-04465-2

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Genomewide Association Study Identifies Copy Number Variants Associated With Warfarin Dose Response and Risk of Venous Thromboembolism in African Americans

Authors: Honghong Zhang, Cristina Alarcon, Larisa H Cavallari, Edith Nutescu, Gemma L Carvill, Minoli A Perera, Wenndy Hernandez

Journal: Clin Pharmacol Ther

PubMed ID: 36507737

Doi: 10.1002/cpt.2820

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Spike-mediated viral membrane fusion is inhibited by a specific anti-IFITM2 monoclonal antibody

Authors: Anna Basile , Carla Zannella , Margot De Marco , Giuseppina Sanna , Gianluigi Franci , Massimiliano Galdiero , Aldo Manzin , Vincenzo De Laurenzi , Massimiliano Chetta , Alessandra Rosati , Maria Caterina Turco , Liberato Marzullo

Journal: Antiviral Res

PubMed ID: 36669656

Doi: 10.1016/j.antiviral.2023.105546

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Identification of B-Cell Epitopes on Capsid Protein Reveals Two Potential Neutralization Mechanisms in Red-Spotted Grouper Nervous Necrosis Virus

Authors: Zhiqi Zhang, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan

Journal: J Virol

PubMed ID: 36633407

Doi: 10.1128/jvi.01748-22

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Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy

Authors: Justin M Quiles, Rita H Najor, Eileen Gonzalez, Monica Jeung, Wenjing Liang, Sarah M Burbach, Erika A Zumaya, Rachel Y Diao, Mark A Lampert, Åsa B Gustafsson

Journal: Sci Signal

PubMed ID: 36719945

Doi: 10.1126/scisignal.abo4457

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B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV

Authors: Jacopo Polvere, Massimiliano Fabbiani, Gabiria Pastore, Ilaria Rancan, Barbara Rossetti, Miriam Durante, Sara Zirpoli, Enrico Morelli, Elena Pettini, Simone Lucchesi, Fabio Fiorino, Mario Tumbarello, Annalisa Ciabattini, Francesca Montagnani, Donata Medaglini

Journal: Commun Med (Lond)

PubMed ID: 36717688

Doi: 10.1038/s43856-023-00245-5

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Identification of a Novel Interaction between Prohibitin (PHB-1) and Bovine RuvB-Like AAA ATPase 1

Authors: Prasanna Babu Araveti, Prajna Parimita Kar, Akshay Kuriakose, Achintya Sanju, Kota Arun Kumar, Anand Srivastava

Journal: Microbiol Spectr

PubMed ID: 36651733

Doi: 10.1128/spectrum.02502-22

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The NLRP6 protein is very faintly expressed in several normal and cancerous epithelial cells and may be confused with an unrelated protein

Authors: Abdallah Mound, Gautier Goormachtigh, Fabrice Bray, Stéphanie Flament, Christian Rolando, Richard Ruez, Nathalie Martin, Amélie Decourcelle, Vanessa Dehennaut, Jean-Michel Saliou, Mathias Chamaillard, Corinne Abbadie

Journal: PLoS ONE

PubMed ID: 36662875

Doi: 10.1371/journal.pone.0279028

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Functions of human olfactory mucus and age-dependent changes

Authors: Tomohiro Shirai, Dan Takase, Junkichi Yokoyama, Kuniyuki Nakanishi, Chisaki Uehara, Naoko Saito, Aya Kato-Namba, Keiichi Yoshikawa

Journal: Sci Rep

PubMed ID: 36653421

Doi: 10.1038/s41598-023-27937-1

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Unusual crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing in antigen presentation

Authors: Lenong Li, Xubiao Peng, Mansoor Batliwala, Marlene Bouvier

Journal: Res Sq

PubMed ID: 36747752

Doi: 10.21203/rs.3.rs-2500847/v1

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Comprehensive Comparison of Seven SARS-CoV-2-Specific Surrogate Virus Neutralization and Anti-Spike IgG Antibody Assays Using a Live-Virus Neutralization Assay as a Reference

Authors: Marianne Graninger, Claudia Maria Jani, Elisabeth Reuberger, Katja Prüger, Philipp Gaspar, David Niklas Springer, Christian Borsodi, Lisa Weidner, Susanne Rabady, Elisabeth Puchhammer-Stöckl, Christof Jungbauer, Eva Höltl, Judith Helene Aberle, Karin Stiasny, Lukas Weseslindtner

Journal: Microbiol Spectr

PubMed ID: 36622205

Doi: 10.1128/spectrum.02314-22

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Investigating the Sequence Specific Adsorption Behavior of Polypeptides at the Solid/Liquid Interface

Authors: Christopher S O'Bryan, Timothy J Murdoch, Daniel J Strickland, Katie A Rose, Denis Bendejacq, Daeyeon Lee, Russell J Composto

Journal: Langmuir

PubMed ID: 36637895

Doi: 10.1021/acs.langmuir.2c02292

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Vimentin epigenetic deregulation in Bladder Cancer associates with acquisition of invasive and metastatic phenotype through epithelial-to-mesenchymal transition

Authors: Sara Monteiro-Reis, Vera Miranda-Gonçalves, Catarina Guimarães-Teixeira, Cláudia Martins-Lima, João Lobo, Diana Montezuma, Paula C Dias, Helene Neyret-Kahn, Isabelle Bernard-Pierrot, Rui Henrique, Carmen Jerónimo

Journal: Int J Biol Sci

PubMed ID: 36594099

Doi: 10.7150/ijbs.77181

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Functional characterization of a novel aminoglycoside phosphotransferase, APH(9)-Ic, and its variant from

Authors: Weina Shi, Junwan Lu, Chunlin Feng, Mengdi Gao, Anqi Li, Shuang Liu, Lei Zhang, Xueya Zhang, Qiaoling Li, Hailong Lin, Xi Lin, Kewei Li, Hailin Zhang, Yunliang Hu, Guangli Wang, Qiyu Bao, Weiyan Jiang

Journal: Front Cell Infect Microbiol

PubMed ID: 36699730

Doi: 10.3389/fcimb.2022.1097561

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Lactate oxidase/catalase-displaying nanoparticles efficiently consume lactate in the tumor microenvironment to effectively suppress tumor growth

Authors: Hyukjun Choi, Mirae Yeo, Yujin Kang, Hyo Jeong Kim, Seong Guk Park, Eunjung Jang, Sung Ho Park, Eunhee Kim, Sebyung Kang

Journal: J Nanobiotechnology

PubMed ID: 36597089

Doi: 10.1186/s12951-022-01762-6

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A linear DNA encoding the SARS-CoV-2 receptor binding domain elicits potent immune response and neutralizing antibodies in domestic cats

Authors: Antonella Conforti, Elisa Sanchez, Erika Salvatori, Lucia Lione, Mirco Compagnone, Eleonora Pinto, Fabio Palombo, Emanuela D'Acunto, Alessia Muzi, Giuseppe Roscilli, Yuhua Sun, Brian Viscount, James Hayward, Clay Shorrock, Diego G Diel, Joseph A Impellizeri, Luigi Aurisicchio

Journal: Mol Ther Methods Clin Dev

PubMed ID: 36618106

Doi: 10.1016/j.omtm.2022.12.015

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AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer

Authors: Yongming Fu, Tuoyu Cao, Xiaorui Zou, Yubing Ye, Youhong Liu, Yuchong Peng, Tanggang Deng, Linglong Yin, Xiong Li

Journal: Oncogenesis

PubMed ID: 36593255

Doi: 10.1038/s41389-022-00446-y

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Cellular and humoral immunity to Ebola Zaire glycoprotein and viral vector proteins following immunization with recombinant vesicular stomatitis virus-based Ebola vaccine (rVSVΔG-ZEBOV-GP)

Authors: Vanessa Raabe, Lilin Lai, Juliet Morales, Yongxian Xu, Nadine Rouphael, Richard T Davey, Mark J Mulligan

Journal: Vaccine

PubMed ID: 36725433

Doi: 10.1016/j.vaccine.2023.01.059

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Design of a chimeric ACE-2/Fc-silent fusion protein with ultrahigh affinity and neutralizing capacity for SARS-CoV-2 variants

Authors: Neil M Bodie, Rina Hashimoto, David Connolly, Jennifer Chu, Kazuo Takayama, Bruce D Uhal

Journal: Antib Ther

PubMed ID: 36741194

Doi: 10.1093/abt/tbad001

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Cry51Aa Proteins Are Active against and Show a Mechanism Similar to Pore Formation Model

Authors: Ei Thinzar Soe, Zaw Lin Naing, Caihong Zhang, Lin Lin Niu, Jinrong Tang, Siqi Yu, Zhongwei Ding, Gemei Liang

Journal: J Agric Food Chem

PubMed ID: 36710440

Doi: 10.1021/acs.jafc.2c07244

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Simultaneous enzyme production, Levan-type FOS synthesis and sugar by-products elimination using a recombinant Pichia pastoris strain expressing a levansucrase-endolevanase fusion enzyme

Authors: Ángela Ávila-Fernández, Silvia Montiel, María Elena Rodríguez-Alegría, Luis Caspeta, Agustín López Munguía

Journal: Microb Cell Fact

PubMed ID: 36703199

Doi: 10.1186/s12934-022-02009-7

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Structure of monkeypox virus DNA polymerase holoenzyme

Authors: Qi Peng, Yufeng Xie, Lu Kuai, Han Wang, Jianxun Qi, George F Gao, Yi Shi

Journal: Science (New York, N. Y.)

PubMed ID: 36520947

Doi: 10.1126/science.ade6360

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Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis

Authors: Alhaji H. Janneh, Mohamed Faisal Kassir, F. Cansu Atilgan, Stephen Tomlinson, Shikhar Mehrotra, Besim Ogretmen

Journal: Cell Reports

Doi: doi.org/10.1016/j.celrep.2022.111742

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Structure-activity relationship studies for inhibitors for vancomycin-resistant and human carbonic anhydrases

Authors: Weiwei An, Katrina J Holly, Alessio Nocentini, Ryan D Imhoff, Chad S Hewitt, Nader S Abutaleb, Xufeng Cao, Mohamed N Seleem, Claudiu T Supuran, Daniel P Flaherty

Journal: J Enzyme Inhib Med Chem

PubMed ID: 35758212

Doi: 10.1080/14756366.2022.2092729

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Normal GCAPs partly compensate for altered cGMP signaling in retinal dystrophies associated with mutations in GUCA1A

Authors: Dell'Orco D, Dal Cortivo G.

Journal: Sci Rep

PubMed ID: 31882816

Doi: 10.1038/s41598-019-56606-5

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SUMO monoclonal antibodies vary in sensitivity, specificity, and ability to detect types of SUMO conjugate

Authors: Alexander J Garvin , Alexander J Lanz , Joanna R Morris

Journal: Sci Rep

PubMed ID: 36494414

Doi: 10.1038/s41598-022-25665-6

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Prevalence of Anti-PF4 Antibodies After First and Second ChAdOx1 nCoV-19 Vaccinations in Women With Adverse Events: A Brief Report and Literature Review

Authors: Kye Won Choe, Yong Kwan Lim, Oh Joo Kweon, Mi-Kyung Lee, Jin-Won Chung, Hye Ryoun Kim

Journal: Ann Lab Med

PubMed ID: 36544343

Doi: 10.3343/alm.2023.43.3.299

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Identification of selective hepatitis delta virus ribozyme inhibitors by high-throughput screening of small molecule libraries

Authors: Eirini D Tseligka, Stéphanie Conzelmann, Yves Cambet, Tifany Schaer, Francesco Negro, Sophie Clément

Journal: JHEP Rep

PubMed ID: 36704052

Doi: 10.1016/j.jhepr.2022.100652

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Influence of affinity tags and tobacco PR1a signal peptide on detection, purification and bioactivity analyses of the small oomycete apoplastic effectors

Authors: Jing-Hao Jin, Xue Zhou, Wang Liu, Zi-Hui Zhang, Shen-Xin Huang, Wen-Jing Zhao, Xiao-Ren Chen

Journal: Biotechnol Lett

PubMed ID: 36450976

Doi: 10.1007/s10529-022-03324-0

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Development of a cockroach (Blattella germanica) qPCR for the objective measurement of exposure at home

Authors: Steffi Rocchi, Benoit Valot, Audrey Laboissière, Audrey Guitton, Emeline Scherer, Laurence Millon, Gabriel Reboux

Journal: Sci Total Environ

PubMed ID: 36526200

Doi: 10.1016/j.scitotenv.2022.160965

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BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network

Authors: Xueqin Sun, Olaf Klingbeil, Bin Lu, Caizhi Wu, Carlos Ballon, Meng Ouyang, Xiaoli S Wu, Ying Jin, Yon Hwangbo, Yu-Han Huang, Tim D D Somerville, Kenneth Chang, Jung Park, Taemoon Chung, Scott K Lyons, Junwei Shi, Hannes Vogel, Michael Schulder, Christopher R Vakoc, Alea A Mills

Journal: Nature

PubMed ID: 36544023

Doi: 10.1038/s41586-022-05551-x

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Distinct biogenesis pathways may have led to functional divergence of the human and Drosophila Arglu1 sisRNA

Authors: Seow Neng Chan, Jun Wei Pek

Journal: EMBO Rep

PubMed ID: 36533631

Doi: 10.15252/embr.202154350

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The effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple

Authors: Runmin Che, Changhai Liu, Qi Wang, Wenyan Tu, Ping Wang, Chao Li, Xiaoqing Gong, Ke Mao, Hao Feng, Lili Huang, Pengmin Li, Fengwang Ma

Journal: Autophagy

PubMed ID: 36449354

Doi: 10.1080/15548627.2022.2153573

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Tissue replication and mucosal swab detection of Sosuga virus in Syrian hamsters in the absence of overt tissue pathology and clinical disease

Authors: Stephen R Welch, Jana M Ritter, Amy J Schuh, Sarah C Genzer, Teresa E Sorvillo, Jessica R Harmon, JoAnn D Coleman-McCray, Shilpi Jain, Punya Shrivastava-Ranjan, Josilene Nascimento Seixas, Lindsey B Estetter, Pamela S Fair, Jonathan S Towner, Joel M Montgomery, César G Albariño, Christina F Spiropoulou, Jessica R Spengler

Journal: Antiviral Res

PubMed ID: 36521633

Doi: 10.1016/j.antiviral.2022.105490

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