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Whole genome sequencing of Malaysian colorectal cancer patients reveals specific druggable somatic mutations
Authors: Ryia Illani Mohd Yunos, Nurul-Syakima Ab Mutalib, Jia-Shiun Khoo, Sazuita Saidin, Muhiddin Ishak, Saiful Effendi Syafruddin, Francis Yew Fu Tieng, Najwa Farhah Md Yusof, Mohd Ridhwan Abd Razak, Norshahidah Mahamad Nadzir, Nadiah Abu, Isa Md Rose, Ismail Sagap, Luqman Mazlan, Rahman Jamal
Journal: Front Mol Biosci
PubMed ID: 36866106
Doi: 10.3389/fmolb.2022.997747
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Fragment-Based Phasing of Peptidic Nanocrystals by MicroED
Authors: Logan S Richards, Maria D Flores, Claudia Millán, Calina Glynn, Chih-Te Zee, Michael R Sawaya, Marcus Gallagher-Jones, Rafael J Borges, Isabel Usón, Jose A Rodriguez
Journal: ACS Bio Med Chem Au
PubMed ID: 37096030
Doi: 10.1021/acsbiomedchemau.2c00082
Products & Services: Peptide Synthesis   
DhFIG_2, a gene of nematode-trapping fungus Dactylellina haptotyla that encodes a component of the low-affinity calcium uptake system, is required for conidiation and knob-trap formation
Authors: Xiaozhou Zhao, Yani Fan, Weiwei Zhang, Meichun Xiang, Seogchan Kang, Shunxian Wang, Xingzhong Liu
Journal: Fungal Genet Biol
PubMed ID: 36849068
Doi: 10.1016/j.fgb.2023.103782
Products & Services: Gene Synthesis   
A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma
Authors: Xianli Du, Jing Pang, Bin Gu, Tian Si, Yan Chang, Tianqi Li, Min Wu, Zicheng Wang, Yuxia Wang, Jiannan Feng, Ning Wu, Jianghong Man, Huiyan Li, Ailing Li, Tong Zhang, Bo Wang, Xiaotao Duan
Journal: Nucleic Acids Res
PubMed ID: 36660824
Doi: 10.1093/nar/gkad002
Mindin Activates Autophagy for Lipid Utilization and Facilitates White Spot Syndrome Virus Infection in Shrimp
Authors: Jie Gao, Ye-Jia Song, Hao Wang, Bao-Rui Zhao, Xian-Wei Wang
Journal: MBio
PubMed ID: 36779788
Doi: 10.1128/mbio.02919-22
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N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy
Authors: Hidehiko Okuma, Jeffrey M Hord, Ishita Chandel, David Venzke, Mary E Anderson, Ameya S Walimbe, Soumya Joseph, Zeita Gastel, Yuji Hara, Fumiaki Saito, Kiichiro Matsumura, Kevin P Campbell
Journal: Elife
PubMed ID: 36723429
Doi: 10.7554/eLife.82811
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Planthopper salivary sheath protein LsSP1 contributes to manipulation of rice plant defenses
Authors: Hai-Jian Huang, Yi-Zhe Wang , Li-Li Li , Hai-Bin Lu, Jia-Bao Lu, Xin Wang , Zhuang-Xin Ye , Ze-Long Zhang, Yu-Juan He, Gang Lu , Ji-Chong Zhuo , Qian-Zhuo Mao , Zong-Tao Sun , Jian-Ping Chen, Jun-Min Li , Chuan-Xi Zhang
Journal: Nat Commun .
PubMed ID: 36759625
Doi: 10.1038/s41467-023-36403-5
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Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules
Authors: Yan-Hong Ma, Xu Hong, Fang Wu, Xin-Feng Xu, Rui Li, Jin Zhong, Yao-Qi Zhou, Shu-Wen Liu, Jian Zhan, Wei Xu
Journal: Acta Pharmacol Sin
PubMed ID: 36759643
Doi: 10.1038/s41401-023-01055-0
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De novo assembled transcriptomics assisted label-free quantitative proteomics analysis reveals sex-specific proteins in the intestinal tissue of Haemaphysalis qinghaiensis
Authors: Hejia Ma, Eloiza May Galon, Yanjun Lao, Ming Kang, Xuenan Xuan, Jixu Li, Yali Sun
Journal: Infect Genet Evol
PubMed ID: 36773671
Doi: 10.1016/j.meegid.2023.105409
Products & Services: PCR Cloning and Subcloning   
Transferrin Receptor Protein 1 Is an Entry Factor for Rabies Virus
Authors: Xinxin Wang, Zhiyuan Wen, Huizhen Cao, Jie Luo, Lei Shuai, Chong Wang, Jinying Ge, Xijun Wang, Zhigao Bu, Jinliang Wang
Journal: J Virol
PubMed ID: 36779762
Doi: 10.1128/jvi.01612-22
Lipid-induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells
Authors: Eshani Karmakar, Nabanita Das, Bidisha Mukherjee, Prosenjit Das, Satinath Mukhopadhyay, Sib Sankar Roy
Journal: Biochem Cell Biol
PubMed ID: 36787544
Doi: 10.1139/bcb-2022-0266
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BioID2 screening identifies KIAA1671 as an EPS8 proximal factor that marks sites of microvillus growth
Authors: Isabella M Gaeta, Matthew J Tyska
Journal: Mol Biol Cell
PubMed ID: 36790915
Doi: 10.1091/mbc.E22-11-0498
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Function of the bacteriophage P2 baseplate central spike Apex domain in the infection process
Authors: John-Mark Miller, Ekaterina S Knyazhanskaya, Sergii A Buth, Nikolai S Prokhorov, Petr G Leiman
Journal: biorxiv
PubMed ID: 36865152
Doi: 10.1101/2023.02.25.529910
Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment
Authors: Robin M Hallett, Ester Bonfill-Teixidor, Raffaella Iurlaro, Alexandra Arias, Swetha Raman, Peter Bayliss, Olga Egorova, Almudena Neva-Alejo, Aj Robert McGray, Esther Lau, Alexandre Bosch, Melissa Beilschmidt, Dorothea Maetzel, Johan Fransson, Isabel Huber-Ruano, Judit Anido, Jean-Philippe Julien, Patricia Giblin, Joan Seoane
Journal: Clin Cancer Res
PubMed ID: 36441800
Doi: 10.1158/1078-0432.CCR-21-1888
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Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury
Authors: Jie Chang, Zhanyang Qian, Binyu Wang, Jiang Cao, Sheng Zhang, Fan Jiang, Renyi Kong, Xiao Yu, Xiaojian Cao, Lei Yang, Hongtao Chen
Journal: Cell Commun Signal
PubMed ID: 36797790
Doi: 10.1186/s12964-022-01036-6
Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapy
Authors: Natalia Plewa, Lucia Poncette, Thomas Blankenstein
Journal: J Immunother Cancer
PubMed ID: 36822673
Doi: 10.1136/jitc-2022-006001
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The SpACE-CCM: A facile and versatile cell culture medium-based biosensor for detection of SARS-CoV-2 spike-ACE2 interaction
Authors: Youngwook Ham, Nam-Chul Cho, Daeyong Kim, Jung-Hee Kim, Min Ju Jo, Min Seon Jeong, Bo-Yeong Pak, Sanghyeok Lee, Mi-Kyung Lee, Seung-Wook Chi, Tae-Don Kim, Nak Cheol Jeong, Sungchan Cho
Journal: Biosens Bioelectron
PubMed ID: 36827795
Doi: 10.1016/j.bios.2023.115169
Products & Services: Molecular Biology Reagents   
Tuning the Microenvironment to Create Functionally Distinct Mesenchymal Stromal Cell Spheroids
Authors: Victoria L Thai, Diego O Candelas, J Kent Leach
Journal: Ann Biomed Eng
PubMed ID: 36809393
Doi: 10.1007/s10439-023-03162-9
Products & Services: Molecular Biology Reagents   
Non-specific and specific DNA binding modes of bacterial histone, HU, separately regulate distinct physiological processes through different mechanisms
Authors: Subhash C Verma, Adam Harned, Kedar Narayan, Sankar Adhya
Journal: Mol Microbiol
PubMed ID: 36708073
Doi: 10.1111/mmi.15033
Design of a Tumor Binding GMCSF as Intratumoral Immunotherapy of Solid Tumors
Authors: Aparna Raghavachar Chakravarti, Chad E Groer, Huan Gong, Vivian Yudistyra, Marcus Laird Forrest, Cory J Berkland
Journal: Mol Pharm
PubMed ID: 36825806
Doi: 10.1021/acs.molpharmaceut.2c00897
Products & Services: Gene Synthesis   
CYCLIN-DEPENDENT KINASE 8 positively regulates oil synthesis by activating WRINKLED1 transcription
Authors: Zhiyang Zhai, Jantana K Blanford, Yingqi Cai, Jing Sun, Hui Liu, Hai Shi, Jorg Schwender, John Shanklin
Journal: New Phytol
PubMed ID: 36683527
Doi: 10.1111/nph.18764
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pH-Sensitive and Biodegradable Mn3(PO4)2·3H2O Nanoparticles as an Adjuvant of Protein-Based Bivalent COVID-19 Vaccine to Induce Potent and Broad-Spectrum Immunity
Authors: Shi-Hao Zhou,‡Ru-Yan Zhang,Zi-Wei You, Yong-Ke Zou, Yu Wen, Jian Wang, Dong Ding, Miao-Miao Bian, Zhi-Ming Zhang, Hong Yuan, Guang-Fu Yang, and Jun Guo
Journal: ACS Applied Materials & Interfaces
Doi: 10.1021/acsami.2c19736
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A novel binary pesticidal protein from Chryseobacterium arthrosphaerae controls western corn rootworm by a different mode of action to existing commercial pesticidal proteins
Authors: Rania Jabeur, Virginie Guyon, Szabolcs Toth, Adriano E Pereira, Man P Huynh, Zakia Selmani, Erin Boland, Mickael Bosio, Laurent Beuf, Pete Clark, David Vallenet, Wafa Achouak, Carine Audiffrin, François Torney, Wyatt Paul, Thierry Heulin, Bruce E Hibbard, Stefan Toepfer, Christophe Sallaud
Journal: PLoS ONE
PubMed ID: 36800363
Doi: 10.1371/journal.pone.0267220
Mechanistic Basis for a Connection between the Catalytic Step and Slow Opening Dynamics of Adenylate Kinase
Authors: Beata Dulko-Smith, Pedro Ojeda-May, Jörgen Ådén, Magnus Wolf-Watz, Kwangho Nam
Journal: J Chem Inf Model
PubMed ID: 36802243
Doi: 10.1021/acs.jcim.2c01629
Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease
Authors: Raaj S Mehta, Jared R Mayers, Yancong Zhang, Amrisha Bhosle, Nathaniel R Glasser, Long H Nguyen, Wenjie Ma, Sena Bae, Tobyn Branck, Kijun Song, Luke Sebastian, Julian Avila Pacheco, Hyuk-Soo Seo, Clary Clish, Sirano Dhe-Paganon, Ashwin N Ananthakrishnan, Eric A Franzosa, Emily P Balskus, Andrew T Chan, Curtis Huttenhower
Journal: Nat Med
PubMed ID: 36823301
Doi: 10.1038/s41591-023-02217-7
Exocytic machineries differentially control mediator release from allergen-triggered RBL-2H3 cells
Authors: Pratikshya Adhikari, Tolulope E Ayo, John C Vines, Shuzo Sugita, Hao Xu
Journal: Inflamm Res
PubMed ID: 36725743
Doi: 10.1007/s00011-023-01698-z
Mechanism of inhibition of CRISPR-Cas9 by anti-CRISPR protein AcrIIC1
Authors: Yalan Zhu, Sen Yin, Zhao Li
Journal: Biochem Biophys Res Commun
PubMed ID: 36878037
Doi: 10.1016/j.bbrc.2023.02.065
Products & Services: Molecular Biology Reagents   
Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants
Authors: Haisheng Yu, Banghui Liu, Yudi Zhang, Xijie Gao, Qian Wang, Haitao Xiang, Xiaofang Peng, Caixia Xie, Yaping Wang, Peiyu Hu, Jingrong Shi, Quan Shi, Pingqian Zheng, Chengqian Feng, Guofang Tang, Xiaopan Liu, Liliangzi Guo, Xiumei Lin, Jiaojiao Li, Chuanyu Liu, Yaling Huang, Naibo Yang, Qiuluan Chen, Zimu Li, Mengzhen Su, Qihong Yan, Rongjuan Pei, Xinwen Chen, Longqi Liu, Fengyu Hu, Dan Liang, Bixia Ke, Changwen Ke, Feng Li, Jun He, Meiniang Wang, Ling Chen, Xiaoli Xiong, Xiaoping Tang
Journal: Nat Commun
PubMed ID: 36828833
Doi: 10.1038/s41467-023-36761-0
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Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase
Authors: Nadine T Werner, Philipp Högel, Gökhan Güner, Walter Stelzer, Manfred Wozny, Marlene Aßfalg, Stefan F Lichtenthaler, Harald Steiner, Dieter Langosch
Journal: Commun Biol
PubMed ID: 36792683
Doi: 10.1038/s42003-023-04470-5
Products & Services: Gene Synthesis   
Expression, purification, and characterisation of the p53 binding domain of Retinoblastoma binding protein 6 (RBBP6)
Authors: Bonnie L Russell, Monde Ntwasa
Journal: PLoS ONE
PubMed ID: 36763571
Doi: 10.1371/journal.pone.0277478
LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway
Authors: Sijia Han, Xueying Jin, Tianyu Hu, Feng Chi
Journal: Oncol Rep
PubMed ID: 36799186
Doi: 10.3892/or.2023.8497
Products & Services: Stable Cell Lines   
ACE2 binding and antibody evasion in enhanced transmissibility of XBB15
Authors: Can Yue, Weiliang Song, Lei Wang, Fanchong Jian, Xiaosu Chen, Fei Gao, Zhongyang Shen, Youchun Wang, Xiangxi Wang, Yunlong Cao
Journal: Lancet Infect Dis
PubMed ID: 36746173
Doi: 10.1016/S1473-3099(23)00010-5
MTORC2 is a physiological hydrophobic motif kinase of S6 Kinase 1
Authors: Sheikh Tahir Majeed, Rabiya Majeed, Aijaz A Malik, Khurshid Iqbal Andrabi
Journal: Biochim Biophys Acta Mol Cell Res
PubMed ID: 36858209
Doi: 10.1016/j.bbamcr.2023.119449
Products & Services: Catalog Peptides   
A Physiologically Responsive Nanocomposite Hydrogel for Treatment of Head and Neck Squamous Cell Carcinoma via Proteolysis-Targeting Chimeras Enhanced Immunotherapy
Authors: Yaping Wu, Xiaowei Chang, Guizhu Yang, Li Chen, Qi Wu, Jiamin Gao, Ran Tian, Wenyun Mu, John Justin Gooding, Xin Chen, Shuyang Sun
Journal: Adv Mater
PubMed ID: 36656993
Doi: 10.1002/adma.202210787
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Functionalized biomimetic nanoparticles combining programmed death-1/programmed death-ligand 1 blockade with photothermal ablation for enhanced colorectal cancer immunotherapy.
Authors: Yuchen Xiao, Tianchuan Zhu, Qi Zeng, Qingqin Tan, Guanmin Jiang, Xi Huang
Journal: Acta Biomater
PubMed ID: 36442821
Doi: 10.1016/j.actbio.2022.11.043
Revealing the role of tunable amino acid residues in elastin-like polypeptides (ELPs)-mediated biomimetic silicification
Authors: Yue Qiu , Yuanqing Lin , Bo Zeng , Peiliang Qin , Zhiwei Yi , Guangya Zhang
Journal: Int J Biol Macromol
PubMed ID: 36539170
Doi: 10.1016/j.ijbiomac.2022.12.152
Products & Services: Gene Synthesis   
Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations
Authors: Joseph H Garcia, Erin A Akins, Saket Jain, Kayla J Wolf, Jason Zhang, Nikita Choudhary, Meeki Lad, Poojan Shukla, Sabraj Gill, Will Carson, Luis Carette, Allison Zheng, Sanjay Kumar, Manish K Aghi
Journal: biorxiv
PubMed ID: 36865128
Doi: 10.1101/2023.02.23.529575
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Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres
Authors: Radka Storchova, Matous Palek, Natalie Palkova, Pavel Veverka, Tomas Brom, Ctirad Hofr, Libor Macurek
Journal: Nucleic Acids Res
PubMed ID: 36651296
Doi: 10.1093/nar/gkac1269
Products & Services: Peptide Synthesis   
Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice
Authors: Matthew T Birnie, Annabel K Short, Gregory B de Carvalho, Lara Taniguchi, Benjamin G Gunn, Aidan L Pham, Christy A Itoga, Xiangmin Xu, Lulu Y Chen, Stephen V Mahler, Yuncai Chen, Tallie Z Baram
Journal: Nat Commun
PubMed ID: 36841826
Doi: 10.1038/s41467-023-36780-x
Retinoblastoma Expression and Targeting by CDK4/6 Inhibitors in Small Cell Lung Cancer
Authors: Gary Wildey, Ashley M Shay, Karen S McColl, Suzy Yoon, Mohammad A Shatat, Ahmad Perwez, Kyle B Spainhower, Adam M Kresak, MaryBeth Lipka, Michael Yang, Mohadese Behtaj, Pingfu Fu, Asrar Alahmadi, Wadad Mneimneh, Ata Abbas, Afshin Dowlati
Journal: Mol Cancer Ther
PubMed ID: 36399634
Doi: 10.1158/1535-7163.MCT-22-0365
Products & Services: Molecular Biology Reagents   
Time-Course Transcriptome Profiling Reveals Differential Resistance Responses of Tomato to a Phytotoxic Effector of the Pathogenic Oomycete
Authors: Xue Zhou, Ke Wen, Shen-Xin Huang, Yi Lu, Yang Liu, Jing-Hao Jin, Shiv D Kale, Xiao-Ren Chen
Journal: Plants (Basel)
PubMed ID: 36840230
Doi: 10.3390/plants12040883
Antagonism between Prdm16 and Smad4 specifies the trajectory and progression of pancreatic cancer
Authors: Eric Hurwitz, Parash Parajuli, Seval Ozkan, Celine Prunier, Thien Ly Nguyen, Deanna Campbell, Creighton Friend, Allyn Austin Bryan, Ting-Xuan Lu, Steven Christopher Smith, Mohammed Shawkat Razzaque, Keli Xu, Azeddine Atfi
Journal: J Cell Biol
PubMed ID: 36828547
Doi: 10.1083/jcb.202203036
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Enhancement of Cell Adhesion by Nucleolin-Interacting Protein AFAP
Authors: Hongcheng Tang, Daxiu Zhang, Fenfen Jiang, Lifeng Yu, Hui Tang, Jiafeng Zhu, Shuyan Wu, Hua Niu
Journal: J Pers Med
PubMed ID: 36836536
Doi: 10.3390/jpm13020302
Products & Services: Plasmid DNA Preparation   
FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner
Authors: Yaguang Bi, Shuolin Liu, Xing Qin, Miyesaier Abudureyimu, Lu Wang, Rongjun Zou, Amir Ajoolabady, Wenjing Zhang, Hu Peng, Jun Ren, Yingmei Zhang
Journal: J Adv Res
PubMed ID: 36828120
Doi: 10.1016/j.jare.2023.02.012
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A cercarial invadolysin interferes with the host immune response and facilitates infection establishment of Schistosoma mansoni
Authors: Jacob R Hambrook, Patrick C Hanington
Journal: PLoS Pathog
PubMed ID: 36730464
Doi: 10.1371/journal.ppat.1010884
Products & Services: Polyclonal Antibody Services   
Microenvironment-responsive anti-PD-L1 × CD3 bispecific T-cell engager for solid tumor immunotherapy
Authors: Dingkang Liu, Lichen Bao, Haichao Zhu, Yali Yue, Jing Tian, Xiangdong Gao, Jun Yin
Journal: Journal of controlled release
PubMed ID: 36669532
Doi: 10.1016/j.jconrel.2023.01.041
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Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner
Authors: Yiru Long , Runqiu Chen , Xiaolu Yu , Yongliang Tong , Xionghua Peng , Fanglin Li , Chao Hu, Jianhua Sun , Likun Gong
Journal: Cancer Immunol Res .
PubMed ID: 36484740
Doi: 10.1158/2326-6066.CIR-22-0439
Products & Services: Recombinant Proteins   
A natriuretic peptide molecule from Vigna angularis, VaEG45, confers rust resistance by inhibiting fungal development
Authors: Weina Sun , Mengqi Yuan , Lihua Yin , Xiwang Ke , Yuhu Zuo
Journal: Plant Cell Rep .
PubMed ID: 36576553
Doi: 10.1007/s00299-022-02967-7
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Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser
Authors: Rebecca J Jernigan , Dhenugen Logeswaran , Diandra Doppler , Nirupa Nagaratnam , Mukul Sonker , Jay-How Yang , Gihan Ketawala , Jose M Martin-Garcia , Megan L Shelby , Thomas D Grant , Valerio Mariani , Alexandra Tolstikova , Michelle Z Sheikh , Mimi Cho Yung , Matthew A Coleman , Sahba Zaare , Emily K Kaschner , Mohammad Towshif Rabbani , Reza Nazari , Michele A Zacks , Brandon Hayes , Raymond G Sierra , Mark S Hunter , Stella Lisova , Alexander Batyuk , Christopher Kupitz , Sebastien Boutet , Debra T Hansen , Richard A Kirian , Marius Schmidt , Raimund Fromme , Matthias Frank , Alexandra Ros , Julian J-L Chen , Sabine Botha , Petra Fromme
Journal: Structure.
PubMed ID: 36630960
Doi: 10.1016/j.str.2022.12.009
Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes
Authors: Yi Sun, Georgia F Papadaki, Christine A Devlin, Julia N Danon, Michael C Young, Trenton J Winters, George M Burslem, Erik Procko, Nikolaos G Sgourakis
Journal: Sci Adv
PubMed ID: 36827371
Doi: 10.1126/sciadv.ade7151
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Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives
Authors: Yee Han Tee, Wei Jia Goh, Xianbin Yong, Hui Ting Ong, Jinrong Hu, Ignacius Yan Yun Tay, Shidong Shi, Salma Jalal, Samuel F H Barnett, Pakorn Kanchanawong, Wenmao Huang, Jie Yan, Yong Ann Ben Lim, Visalatchi Thiagarajan, Alex Mogilner, Alexander D Bershadsky
Journal: Nat Commun
PubMed ID: 36774346
Doi: 10.1038/s41467-023-35918-1
Establishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection
Authors: Pei-Fen Zhang, Zi-Yi Wu, Wen-Bin Zhang, Yong-Qiao He, Kexin Chen, Tong-Min Wang, Haixin Li, Hong Zheng, Dan-Hua Li, Da-Wei Yang, Ting Zhou, Chang-Mi Deng, Ying Liao, Wen-Qiong Xue, Lian-Jing Cao, Xi-Zhao Li, Jiang-Bo Zhang, Si-Qi Dong, Fang Wang, Mei-Qi Zheng, Wen-Li Zhang, Jianbing Mu, Wei-Hua Jia
Journal: Nat Commun
PubMed ID: 36746966
Doi: 10.1038/s41467-023-36374-7
Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols
Authors: Calvin Dumesnil, Lauri Vanharanta, Xavier Prasanna, Mohyeddine Omrane, Maxime Carpentier, Apoorva Bhapkar, Giray Enkavi, Veijo T Salo, Ilpo Vattulainen, Elina Ikonen, Abdou Rachid Thiam
Journal: Nat Commun
PubMed ID: 36807572
Doi: 10.1038/s41467-023-36375-6
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SARS-CoV-2 Main Protease Targets Host Selenoproteins and Glutathione Biosynthesis for Knockdown via Proteolysis, Potentially Disrupting the Thioredoxin and Glutaredoxin Redox Cycles
Authors: Ignacio A Gallardo, Daniel A Todd, Stella T Lima, Jonathan R Chekan, Norman H Chiu, Ethan Will Taylor
Journal: Antioxidants (Basel)
PubMed ID: 36978807
Doi: 10.3390/antiox12030559
Heteromultivalent scaffolds fabricated by biomimetic co-assembly of DNA-RNA building blocks for the multi-analysis of miRNAs
Authors: Chengjie Duan, Yan Chen, Zhiqiang Hou, Dayong Li, Jin Jiao, Weihao Sun, Yang Xiang
Journal: J Mater Chem B
PubMed ID: 36723144
Doi: 10.1039/d2tb02663e
Chikungunya Virus and Its Envelope Protein E2 Induce Hyperalgesia in Mice: Inhibition by Anti-E2 Monoclonal Antibodies and by Targeting TRPV1
Authors: Carina Z Segato-Vendrameto, Camila Zanluca, Amanda Z Zucoloto, Tiago H Zaninelli, Mariana M Bertozzi, Telma Saraiva-Santos, Camila R Ferraz, Larissa Staurengo-Ferrari, Stephanie Badaro-Garcia, Marília F Manchope, Amanda M Dionisio, Felipe A Pinho-Ribeiro, Sergio M Borghi, Ana Luiza Pamplona Mosimann, Rubia Casagrande, Juliano Bordignon, Victor Fattori, Claudia N Duarte Dos Santos, Waldiceu A Verri
Journal: Cells
PubMed ID: 36831223
Doi: 10.3390/cells12040556
Products & Services: Codon Optimization   
How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member
Authors: Juan C Opazo, Michael W Vandewege, Federico G Hoffmann, Kattina Zavala, Catalina Meléndez, Charlotte Luchsinger, Viviana A Cavieres, Luis Vargas-Chacoff, Francisco J Morera, Patricia V Burgos, Cheril Tapia-Rojas, Gonzalo A Mardones
Journal: Mol Biol Evol
PubMed ID: 36656997
Doi: 10.1093/molbev/msad014
Products & Services: Plasmid DNA Preparation   
Functional analysis of 110 phosphorylation sites on the circadian clock protein FRQ identifies clusters determining period length and temperature compensation
Authors: Bin Wang, Elizabeth-Lauren Stevenson, Jay C Dunlap
Journal: G3 (Bethesda)
PubMed ID: 36537198
Doi: 10.1093/g3journal/jkac334
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Selective excitation with recoupling pulse schemes uncover properties of disordered mineral phases in bone-like apatite grown with bone proteins
Authors: Irina Matlahov, Alexey Kulpanovich, Taly Iline-Vul, Merav Nadav-Tsubery, Gil Goobes
Journal: Solid State Nucl Magn Reson
PubMed ID: 36913847
Doi: 10.1016/j.ssnmr.2023.101860
Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease
Authors: Rui Zhao, Li Cao, Wen-Jun Gu, Lei Li, Zhong-Zhong Chen, Jie Xiang, Ze-Yu Zhou, Bo Xu, Wei-Dong Zang, Xiang-Yu Zhou, Jing Cao, Kun Sun, Jian-Yuan Zhao
Journal: Cell Rep Med
PubMed ID: 36809766
Doi: 10.1016/j.xcrm.2023.100953
A midposition NOTCH3 truncation in inherited cerebral small vessel disease may affect the protein interactome
Authors: Soo Jung Lee , Xiaojie Zhang , Gang Xu , Jimo Borjigin , Michael M Wang
Journal: J Biol Chem .
PubMed ID: 36470429
Doi: 10.1016/j.jbc.2022.102772
Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants
Authors: Saskia Meyer , Isaac Blaas , Ravi Chand Bollineni , Marina Delic-Sarac , Trung T Tran , Cathrine Knetter , Ke-Zheng Dai , Torfinn Støve Madssen , John T Vaage , Alice Gustavsen , Weiwen Yang , Lise Sofie Haug Nissen-Meyer , Karolos Douvlataniotis , Maarja Laos , Morten Milek Nielsen , Bernd Thiede , Arne Søraas , Fridtjof Lund-Johansen , Even H Rustad, Johanna Olweus
Journal: Cell Rep .
PubMed ID: 36656713
Doi: 10.1016/j.celrep.2023.111995
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Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor
Authors: Jia Duan , Peiyu Xu , Huibing Zhang , Xiaodong Luan , Jiaqi Yang, Xinheng He , Chunyou Mao , Dan-Dan Shen , Yujie Ji , Xi Cheng , Hualiang Jiang , Yi Jiang , Shuyang Zhang , Yan Zhang , H Eric Xu
Journal: Nat Commun .
PubMed ID: 36720854
Doi: 10.1038/s41467-023-36170-3
Wheat yellow mosaic virus NIb targets TaVTC2 to elicit broad-spectrum pathogen resistance in wheat.
Authors: Zhang Tianye, Hu Haichao, Wang Ziqiong, Feng Tianyou, Yu Lu, Jie Zhang, Gao Wenqing, Zhou Yilin, Meihao Sun, Peng Liu, Zhong Kaili, Chen ZhiHui, Jianping Chen, Wei Li, Jian Yang
Journal: Plant Biotechnology Journal
PubMed ID: 36715229
Doi: 10.1111/pbi.14019
Simultaneous capture of ISG15 conjugating and deconjugating enzymes using a semi-synthetic ISG15-Dha probe
Authors: Chuntong Li, Tian Wang, Lujun Liang, Guochao Chu, Jiachen Zhang, Wei He, Lei Liu, Jinghong Li
Journal: Science China. Chemistry
PubMed ID: 36684644
Doi: 10.1007/s11426-022-1455-x
lectrochemical and Structural Study of the Buried Tryptophan in Azurin: Effects of Hydration and Polarity on the Redox Potential of W48
Authors: Kristin Tyson, Chanin B Tangtartharakul, Matthias Zeug, Nathan Findling, Alice Haddy, Eli Hvastkovs, Jun-Yong Choe, Judy E Kim, Adam R Offenbacher
Journal: The Journal of Physical Chemistry. B
PubMed ID: 36542812
Doi: 10.1021/acs.jpcb.2c06677
Products & Services: Gene Synthesis   
Cryo-EM structures of orphan GPR21 signaling complexes
Authors: Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng, Suwen Zhao, Fei Xu
Journal: nature communications
PubMed ID: 36639690
Doi: 10.1038/s41467-023-35882-w
Products & Services: Gene Services   
Subunit Vaccine Targeting Phosphate ABC Transporter ATP-Binding Protein, PstB, Provides Cross-Protection against Serotype 2, 7, and 9 in Mice
Authors: Zujie Yan, Xiaohui Yao, Ruyi Pan, Junjie Zhang, Xiaochun Ma, Nihua Dong, Jianchao Wei, Ke Liu, Yafeng Qiu, Katie Sealey, Hester Nichols, Michael A Jarvis, Mathew Upton, Xiangdong Li, Zhiyong Ma, Juxiang Liu, Beibei Li
Journal: Vet Sci
PubMed ID: 36669049
Doi: 10.3390/vetsci10010048
A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells
Authors: Kakeru Sato, Tatsuya Seki, Asuka Mizutani, Yuka Muranaka, Shiho Hirota, Kodai Nishi, Kana Yamazaki, Ryuichi Nishii, Takeo Nakanishi, Ikumi Tamai, Keiichi Kawai, Masato Kobayashi
Journal: Front Pharmacol
PubMed ID: 36712667
Doi: 10.3389/fphar.2022.1069321
Transcriptomic exploration of the Coleopteran wings reveals insight into the evolution of novel structures associated with the beetle elytron
Authors: David M Linz, Yuichiro Hara, Kevin D Deem, Shigehiro Kuraku, Shigeo Hayashi, Yoshinori Tomoyasu
Journal: J Exp Zool B Mol Dev Evol
PubMed ID: 36617687
Doi: 10.1002/jez.b.23188
Products & Services: Molecular Biology Reagents   
Calmodulin variants associated with congenital arrhythmia impair selectivity for ryanodine receptors
Authors: Giuditta Dal Cortivo, Valerio Marino, Silvia Bianconi, Daniele Dell'Orco
Journal: Front Mol Biosci
PubMed ID: 36685279
Doi: 10.3389/fmolb.2022.1100992
Products & Services: DNA Sequencing   
Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation
Authors: Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Michael Bowman, Lih-Ling Lin, Hao Wu, James Jeiwen Chou
Journal: Cell Res
PubMed ID: 36604598
Doi: 10.1038/s41422-022-00755-2
Products & Services: Plasmid DNA Preparation   
Vaccination with S, an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice
Authors: Yongliang Zhao, Wenjia Ni, Simeng Liang, Lianghui Dong, Min Xiang, Zeng Cai, Danping Niu, Qiuhan Zhang, Dehe Wang, Yucheng Zheng, Zhen Zhang, Dan Zhou, Wenhua Guo, Yongbing Pan, Xiaoli Wu, Yimin Yang, Zhaofei Jing, Yongzhong Jiang, Yu Chen, Huan Yan, Yu Zhou, Ke Xu, Ke Lan
Journal: Sci Transl Med
PubMed ID: 36599007
Doi: 10.1126/scitranslmed.abo3332
Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress
Authors: Samuel C Woodburn, Helina S Asrat, James K Flurer, Hana C Schwierling, Justin L Bollinger, Lauren L Vollmer, Eric S Wohleb
Journal: Brain Behav Immun
PubMed ID: 36681359
Doi: 10.1016/j.bbi.2023.01.014
Chronic intermittent hypoxia-induced BNIP3 expression mitigates contractile dysfunction and myocardial injury in animal and cell model via modulating autophagy
Authors: Ruifang Chi, Chanjuan Chai, Gaizhen Liu, Huili Cao, Bin Yang
Journal: Hum Cell
PubMed ID: 36627546
Doi: 10.1007/s13577-022-00851-w
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Exploring the Expression and Function of cTyro3, a Candidate Zika Virus Receptor, in the Embryonic Chicken Brain and Inner Ear
Authors: Vashi Negi, Richard J Kuhn, Donna M Fekete
Journal: Viruses
PubMed ID: 36680287
Doi: 10.3390/v15010247
Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding Antibodies
Authors: Kenya Moore, Urmi Sengupta, Nicha Puangmalai, Nemil Bhatt, Rakez Kayed
Journal: Mol Neurobiol
PubMed ID: 36707462
Doi: 10.1007/s12035-023-03211-3
A non-toxic recombinant bivalent chimeric protein rETXCSA as a potential vaccine candidate against enterotoxemia and braxy
Authors: Jige Du, Bo Liu, Tuanjie Wang, Zhen Zhu, Chunsheng Yin, Yufeng Luo, Ying Liu, Xiaoyun Chen
Journal: Vaccine
PubMed ID: 36635138
Doi: 10.1016/j.vaccine.2022.11.021
Products & Services: Molecular Biology Reagents   
Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees
Authors: Pei Yu, Zijian Liu, Zhuoqi Zhu, Jiaqing Yang, Min Deng, Mingxiao Chen, Changchun Lai, Weiya Kong, Shilong Xiong, Li Wan, Weikang Mai, Lu Chen, Yu Lei, Shahzad Akbar Khan, Jianfeng Ruan, An Kang, Xuguang Guo, Qiang Zhou, Wenrui Li, Zheng Chen, Yuemei Liang, Pingchao Li, Lei Zhang, Tianxing Ji
Journal: Virol Sin
PubMed ID: 36603767
Doi: 10.1016/j.virs.2022.12.008
Products & Services: Molecular Biology Reagents   
Nanocell COVID-19 vaccine triggers a novel immune response pathway producing high-affinity antibodies which neutralize all variants of concern
Authors: Steven Y Gao, Nancy B Amaro-Mugridge, Jocelyn Madrid-Weiss, Nikolina Petkovic, Natasha Vanegas, Kumar Visvanathan, Bryan R G Williams, Jennifer A MacDiarmid, Himanshu Brahmbhatt
Journal: Front Immunol
PubMed ID: 36818474
Doi: 10.3389/fimmu.2022.1038562
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Detection and Molecular Characterization of the SARS-CoV-2 Delta Variant and the Specific Immune Response in Companion Animals in Switzerland
Authors: Evelyn Kuhlmeier, Tatjana Chan, Cecilia Valenzuela Agüí, Barbara Willi, Aline Wolfensberger, Christian Beisel, Ivan Topolsky, Niko Beerenwinkel, Tanja Stadler, Sarah Jones, Grace Tyson, Margaret J Hosie, Katja Reitt, Julia Hüttl, Marina L Meli, Regina Hofmann-Lehmann
Journal: Viruses
PubMed ID: 36680285
Doi: 10.3390/v15010245
Defending against SARS-CoV-2: The T cell perspective
Authors: Patricia Almendro-Vázquez, Rocío Laguna-Goya, Estela Paz-Artal
Journal: Front Immunol
PubMed ID: 36776863
Doi: 10.3389/fimmu.2023.1107803
Products & Services: Gene Synthesis   
Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance
Authors: Dario Gerace, Quan Zhou, Jennifer Hyoje-Ryu Kenty, Adrian Veres, Elad Sintov, Xi Wang, Kyle R Boulanger, Hongfei Li, Douglas A Melton
Journal: Cell Rep Med
PubMed ID: 36599351
Doi: 10.1016/j.xcrm.2022.100879
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Low-cost and prototype-friendly method for biocompatible encapsulation of implantable electronics with epoxy overmolding, hermetic feedthroughs and P3HT coating
Authors: Marek Novák, Jozef Rosina, Hana Bendová, Kristina Kejlová, Alena Vlková, Marian Rucki, Lada Svobodová, Robert Gürlich, Jan Hajer
Journal: Sci Rep
PubMed ID: 36717683
Doi: 10.1038/s41598-023-28699-6
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Dependency of sanitation infrastructure on the discharge of faecal coliform and SARS-CoV-2 viral RNA in wastewater from COVID and non-COVID hospitals in Dhaka, Bangladesh
Authors: Nuhu Amin, Rehnuma Haque, Md Ziaur Rahman, Mohammed Ziaur Rahman, Zahid Hayat Mahmud, Rezaul Hasan, Md Tahmidul Islam, Protim Sarker, Supriya Sarker, Shaikh Daud Adnan, Nargis Akter, Dara Johnston, Mahbubur Rahman, Pengbo Liu, Yuke Wang, Tahmina Shirin, Mahbubur Rahman, Prosun Bhattacharya
Journal: Sci Total Environ
PubMed ID: 36623655
Doi: 10.1016/j.scitotenv.2023.161424
Products & Services: Custom DNA/RNA Oligos   
Exploiting natural riboswitches for aptamer engineering and validation
Authors: Michael G Mohsen, Matthew K Midy, Aparaajita Balaji, Ronald R Breaker
Journal: Nucleic Acids Res
PubMed ID: 36617976
Doi: 10.1093/nar/gkac1218
Products & Services: CRISPR Plasmids   
Monosynaptic restriction of the anterograde herpes simplex virus strain H129 for neural circuit tracing
Authors: Kyle B Fischer, Hannah K Collins, Yan Pang, Dheeraj S Roy, Ying Zhang, Guoping Feng, Shu-Jing Li, Adam Kepecs, Edward M Callaway
Journal: J Comp Neurol
PubMed ID: 36606699
Doi: 10.1002/cne.25451
Products & Services: Molecular Biology Reagents   
Evaluation of a biotin-based surrogate virus neutralization test for detecting postvaccination antibodies against SARS-CoV-2 variants in sera
Authors: Min-Ju Ahn, Jung-Ah Kang, Su Min Hong, Kyu-Sun Lee, Dong Ho Kim, Daesub Song, Dae Gwin Jeong
Journal: Biochem Biophys Res Commun
PubMed ID: 36696754
Doi: 10.1016/j.bbrc.2023.01.052
Products & Services: Molecular Biology Reagents   
PLK1 and AURKB phosphorylate survivin differentially to affect proliferation in racially distinct triple-negative breast cancer
Authors: Chakravarthy Garlapati, Shriya Joshi, Shristi Bhattarai, Jayashree Krishnamurthy, Ravi Chakra Turaga, Thi Nguyen, Xiaoxian Li, Ritu Aneja
Journal: Cell Death Dis
PubMed ID: 36627281
Doi: 10.1038/s41419-022-05539-5
Products & Services: Molecular Biology Reagents   
Pold4 is dispensable for mouse development, DNA replication and DNA repair
Authors: Xueping Gu , Qinjin Dai , Peng Du , Ning Li , Jiahui Li , Simiao Zeng , Shuyi Peng , Shengjun Tang , Lei Wang , Zhongcheng Zhou
Journal: Gene
PubMed ID: 36356905
Doi: 10.1016/j.gene.2022.147029
Expression and kinetic characterization of PYCR3 Kaylen
Authors: Kaylen R Meeks , John J Tanner
Journal: Arch Biochem Biophys
PubMed ID: 36414121
Doi: 10.1016/j.abb.2022.109468
Products & Services: Codon Optimization   
Radiotherapy-Triggered Proteolysis Targeting Chimera Prodrug Activation in Tumors
Authors: Chunrong Yang , Yuchen Yang , Yujie Li , Qiankun Ni , Jinghong Li
Journal: J Am Chem Soc.
PubMed ID: 36542856
Doi: 10.1021/jacs.2c10177
RsCLE22a regulates taproot growth through an auxin signaling-related pathway in radish (Raphanus sativus L)
Authors: Junhui Dong, Yan Wang, Liang Xu, Bingshuang Li, Kai Wang, Jiali Ying, Qing He, Liwang Liu
Journal: J Exp Bot
PubMed ID: 36239471
Doi: 10.1093/jxb/erac406
Products & Services: Peptide Synthesis   
Atlantic cod () MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals
Authors: Synne Arstad Bjørnestad, Monica Hongrø Solbakken, Kjetill S Jakobsen, Sissel Jentoft, Oddmund Bakke, Cinzia Progida
Journal: Front Cell Dev Biol
PubMed ID: 36760361
Doi: 10.3389/fcell.2023.1050323
Products & Services: Peptide Synthesis   
Linoleic acid ameliorates intestinal mucosal barrier injury in early weaned pigeon squabs (Columba livia)
Authors: Qianqian Xu, Jin Zhao, Huafeng Jian, Jiangcheng Ye, Mingxiu Gong, Xiaoting Zou, Xinyang Dong
Journal: J Anim Sci
PubMed ID: 37186172
Doi: 10.1093/jas/skad125
Mesenchymal stem cell-derived extracellular vesicles transfer miR-598 to inhibit the growth and metastasis of non-small-cell lung cancer by targeting THBS2
Authors: Xuebo Li, Fan Wu
Journal: Cell Death Discov
PubMed ID: 36609437
Doi: 10.1038/s41420-022-01283-z
Products & Services: Custom DNA/RNA Oligos   
Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates
Authors: Daehun Park, Yumei Wu, Xinbo Wang, Swetha Gowrishankar, Aaron Baublis, Pietro De Camilli
Journal: Nat Commun
PubMed ID: 36709207
Doi: 10.1038/s41467-023-36081-3
Products & Services: Custom Vector Construction   
CRISPR mediated transactivation in the human disease vector Aedes aegypti
Authors: Michelle Bui, Elena Dalla Benetta, Yuemei Dong, Yunchong Zhao, Ting Yang, Ming Li, Igor A Antoshechkin, Anna Buchman, Vanessa Bottino-Rojas, Anthony A James, Michael W Perry, George Dimopoulos, Omar S Akbari
Journal: PLoS Pathog
PubMed ID: 36656895
Doi: 10.1371/journal.ppat.1010842
A method for mapping the linear epitopes targeted by the natural antibody response to Zika virus infection using a VLP platform technology
Authors: Alexandra Fowler, Chunyan Ye, Elizabeth C Clarke, Juan M Pascale, David S Peabody, Steven B Bradfute, Kathryn M Frietze, Bryce Chackerian
Journal: Virology
PubMed ID: 36623351
Doi: 10.1016/j.virol.2023.01.001
Products & Services: Peptide Synthesis   
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