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The antibacterial activity and antibacterial mechanism analyses of an LRR-IG protein in the Chinese mitten crab, Eriocheir sinensis

Authors: Yi Zhang, Yunhui Bai, Qiao Shi, Bin Zhou, Mengqi Ni, Jinbin Zheng, Zhaoxia Cui

Journal: Int J Biol Macromol

PubMed ID: 36801302

Doi: 10.1016/j.ijbiomac.2023.123732

Products & Services: Proteins, Expression, Isolation and Analysis

New Monoclonal Antibodies Specific for Different Epitopes of the Spike Protein of SARS-CoV-2 and Its Major Variants: Additional Tools for a More Specific COVID-19 Diagnosis

Authors: Sabrina Mariotti, Maria Vincenza Chiantore, Raffaela Teloni, Angelo Iacobino, Antonio Capocefalo, Zuleika Michelini, Martina Borghi, Melissa Baggieri, Antonella Marchi, Paola Bucci, Silvia Gioacchini, Raffaele D'Amelio, Philip J M Brouwer, Silvia Sandini, Chiara Acchioni, Marco Sgarbanti, Antonio Di Virgilio, Felicia Grasso, Andrea Cara, Donatella Negri, Fabio Magurano, Paola Di Bonito, Roberto Nisini

Journal: Biomedicines

PubMed ID: 36831149

Doi: 10.3390/biomedicines11020610

Products & Services: Proteins, Expression, Isolation and Analysis

Hyperoxia exposure upregulates Dvl-1 and activates Wnt/β-catenin signaling pathway in newborn rat lung

Authors: Yuting Zhu, Yawen Li, Weilai Jin, Zhengying Li, Le Zhang, Yuanyuan Fang, Yanyu Zhang

Journal: BMC Mol Cell Biol

PubMed ID: 36726071

Doi: 10.1186/s12860-023-00465-6

Products & Services: Catalog Peptides

EGF‑IL2 bispecific and bivalent EGF fusion toxin efficacy against syngeneic head and neck cancer mouse models

Authors: Yue Qiu , Zeng Qi , Zhaohui Wang , Yu Cao , Ling Lu , Huiping Zhang , David Mathes , Elizabeth A Pomfret , Shi-Long Lu , Zhirui Wang

Journal: Oncol Rep

PubMed ID: 36579667

Doi: 10.3892/or.2022.8474

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Novel csuC-DNA nanovaccine based on chitosan candidate vaccine against infection with Acinetobacter baumannii

Authors: Eskandar Hosseinnezhad-Lazarjani, Abbas Doosti, Ali Sharifzadeh

Journal: Vaccine

PubMed ID: 36841724

Doi: 10.1016/j.vaccine.2023.02.046

Products & Services: Proteins, Expression, Isolation and Analysis

DNA aptamer-based affinity chromatography system for purification of recombinant proteins tagged with lysine tag

Authors: Klaudia Arciszewska, Ewa Kowalska, Filip Bartnicki, Piotr Bonarek, Agnieszka Katarzyna Banaś, Wojciech Strzałka

Journal: J Chromatogr A

PubMed ID: 36780846

Doi: 10.1016/j.chroma.2023.463846

Products & Services: Proteins, Expression, Isolation and Analysis

Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2

Authors: Xinxin Wang, Zhiyuan Wen, Huizhen Cao, Jie Luo, Lei Shuai, Chong Wang, Jinying Ge, Xijun Wang, Zhigao Bu, Jinliang Wang

Journal: J Virol

PubMed ID: 36779763

Doi: 10.1128/jvi.01611-22

Products & Services: Catalog Antibody

Lrpap1 (RAP) Inhibits Proximal Tubule Clathrin Mediated and Clathrin Independent Endocytosis, Ameliorating Renal Aminoglycoside Nephrotoxicity

Authors: Mark C Wagner, Ruben M Sandoval, Shiv Pratap S Yadav, Silvia B Campos, George J Rhodes, Carrie L Phillips, Bruce A Molitoris

Journal: Kidney360

PubMed ID: 36848531

Doi: 10.34067/KID.0000000000000094

Products & Services: Proteins, Expression, Isolation and Analysis

Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection

Authors: Alan T Tang, David W Buchholz, Katherine M Szigety, Brian Imbiakha, Siqi Gao, Maxwell Frankfurter, Min Wang, Jisheng Yang, Peter Hewins, Patricia Mericko-Ishizuka, N Adrian Leu, Stephanie Sterling, Isaac A Monreal, Julie Sahler, Avery August, Xuming Zhu, Kellie A Jurado, Mingang Xu, Edward E Morrisey, Sarah E Millar, Hector C Aguilar, Mark L Kahn

Journal: PLoS Biol

PubMed ID: 36745682

Doi: 10.1371/journal.pbio.3001989

Products & Services: Proteins, Expression, Isolation and Analysis

A biallelic loss of function variant in HORMAD1 within a large consanguineous Turkish family is associated with spermatogenic arrest

Authors: Ozlem Okutman, Manon Boivin, Jean Muller, Nicolas Charlet-Berguerand, Stéphane Viville

Journal: Hum Reprod

PubMed ID: 36524333

Doi: 10.1093/humrep/deac259

Products & Services: Proteins, Expression, Isolation and Analysis

Celastrol alleviates oxidative stress induced by multi-walled carbon nanotubes through the Keap1/Nrf2/HO-1 signaling pathway

Authors: Tao-Lin Qing, Lang Yan, Shao-Kang Wang, Xiao-Yu Dai, Li-Jun Ren, Ji-Qian-Zhu Zhang, Wen-Jing Shi, Xiao-Fang Zhang, Mei-Tang Wang, Ji-Kuai Chen, Jiang-Bo Zhu

Journal: Ecotoxicol Environ Saf

PubMed ID: 36774793

Doi: 10.1016/j.ecoenv.2023.114623

Products & Services: Molecular Biology Reagents

Synthesis of Bispecific Antibody Conjugates Using Functionalized Poly-ADP-ribose Polymers

Authors: Qinqin Cheng, Xiao-Nan Zhang, Jiawei Li, Jingwen Chen, Yiling Wang, Yong Zhang

Journal: Biochemistry

PubMed ID: 36821831

Doi: 10.1021/acs.biochem.2c00718

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Multicopy suppressor screens reveal convergent evolution of single-gene lysis proteins

Authors: Benjamin A Adler, Karthik Chamakura, Heloise Carion, Jonathan Krog, Adam M Deutschbauer, Ry Young, Vivek K Mutalik, Adam P Arkin

Journal: Nat Chem Biol

PubMed ID: 36805702

Doi: 10.1038/s41589-023-01269-7

Products & Services: Plasmid DNA Preparation

The Ku complex promotes DNA end-bridging and this function is antagonized by Tel1/ATM kinase

Authors: Carlo Rinaldi, Paolo Pizzul, Erika Casari, Marco Mangiagalli, Renata Tisi, Maria Pia Longhese

Journal: Nucleic Acids Res

PubMed ID: 36762474

Doi: 10.1093/nar/gkad062

Products & Services: Gene Synthesis

Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer's disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assay

Authors: Liding Zhang, Ying Su, Xiaohan Liang, Kai Cao, Qingming Luo, Haiming Luo

Journal: Nano Res

PubMed ID: 37223429

Doi: 10.1007/s12274-022-5354-4

Products & Services: Recombinant Proteins

Glucose-Induced Enhanced Virulence in Strains of Multidrug-Resistant Pseudomonas aeruginosa Isolated from Diabetic Patients

Authors: Sarika Suresh, Akshatha Naik, Ramya Premanath

Journal: Curr Microbiol

PubMed ID: 36752926

Doi: 10.1007/s00284-023-03200-8

Products & Services: PCR Cloning and Subcloning

DUX4 double whammy: The transcription factor that causes a rare muscular dystrophy also kills the precursors of the human nose

Authors: Kaoru Inoue, Hamed Bostan, MaKenna R Browne, Owen F Bevis, Carl D Bortner, Steven A Moore, Aaron A Stence, Negin P Martin, Shih-Heng Chen, Adam B Burkholder, Jian-Liang Li, Natalie D Shaw

Journal: Sci Adv

PubMed ID: 36800423

Doi: 10.1126/sciadv.abq7744

Products & Services: Monoclonal Antibody Services

PERK recruits E-Syt1 at ER-mitochondria contacts for mitochondrial lipid transport and respiration

Authors: Maria Livia Sassano, Alexander R van Vliet, Ellen Vervoort, Sofie Van Eygen, Chris Van den Haute, Benjamin Pavie, Joris Roels, Johannes V Swinnen, Marco Spinazzi, Leen Moens, Kristina Casteels, Isabelle Meyts, Paolo Pinton, Saverio Marchi, Leila Rochin, Francesca Giordano, Blanca Felipe-Abrio, Patrizia Agostinis

Journal: J Cell Biol

PubMed ID: 36821088

Doi: 10.1083/jcb.202206008

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Discovery of Novel Transketolase Epitopes and the Development of IgG-Based Tuberculosis Serodiagnostics

Authors: Jaya Talreja , Changya Peng , Tuan-Minh Nguyen , Sorin Draghici , Lobelia Samavati

Journal: Microbiology Spectrum

PubMed ID: 36651770

Doi: 10.1128/spectrum.03377-22

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A PEG-lipid-free COVID-19 mRNA vaccine triggers robust immune responses in mice

Authors: Min Li , Yixuan Huang , Jiacai Wu , Sanpeng Li , Miao Mei , Haixia Chen , Ning Wang , Weigang Wu , Boping Zhou , Xu Tan , Bin Li

Journal: Materials Horizons

PubMed ID: 36468425

Doi: 10.1039/D2MH01260J

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Planthopper salivary sheath protein LsSP1 contributes to manipulation of rice plant defenses

Authors: Hai-Jian Huang, Yi-Zhe Wang , Li-Li Li , Hai-Bin Lu, Jia-Bao Lu, Xin Wang , Zhuang-Xin Ye , Ze-Long Zhang, Yu-Juan He, Gang Lu , Ji-Chong Zhuo , Qian-Zhuo Mao , Zong-Tao Sun , Jian-Ping Chen, Jun-Min Li , Chuan-Xi Zhang

Journal: Nat Commun .

PubMed ID: 36759625

Doi: 10.1038/s41467-023-36403-5

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NRXN1 depletion in the medial prefrontal cortex induces anxiety-like behaviors and abnormal social phenotypes along with impaired neurite outgrowth in rat

Authors: Di Wu, Jiansheng Zhu, Lianghui You, Jingyu Wang, Sufen Zhang, Zhonghui Liu, Qu Xu, Xiaojie Yuan, Lei Yang, Wei Wang, Meiling Tong, Qin Hong, Xia Chi

Journal: J Neurodev Disord

PubMed ID: 36737720

Doi: 10.1186/s11689-022-09471-9

Products & Services: Molecular Biology Reagents

Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity

Authors: Xiaoge Gao, Pin Jiang, Xiaohuan Wei, Wei Zhang, Jiwei Zheng, Shishuo Sun, Hong Yao, Xiangye Liu, Qing Zhang

Journal: BMC Cancer

PubMed ID: 36793021

Doi: 10.1186/s12885-023-10608-9

Products & Services: Molecular Biology Reagents

Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules

Authors: Yan-Hong Ma, Xu Hong, Fang Wu, Xin-Feng Xu, Rui Li, Jin Zhong, Yao-Qi Zhou, Shu-Wen Liu, Jian Zhan, Wei Xu

Journal: Acta Pharmacol Sin

PubMed ID: 36759643

Doi: 10.1038/s41401-023-01055-0

Products & Services: PCR Cloning and Subcloning

A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma

Authors: Xianli Du, Jing Pang, Bin Gu, Tian Si, Yan Chang, Tianqi Li, Min Wu, Zicheng Wang, Yuxia Wang, Jiannan Feng, Ning Wu, Jianghong Man, Huiyan Li, Ailing Li, Tong Zhang, Bo Wang, Xiaotao Duan

Journal: Nucleic Acids Res

PubMed ID: 36660824

Doi: 10.1093/nar/gkad002

Products & Services: Proteins, Expression, Isolation and Analysis

Transferrin Receptor Protein 1 Is an Entry Factor for Rabies Virus

Authors: Xinxin Wang, Zhiyuan Wen, Huizhen Cao, Jie Luo, Lei Shuai, Chong Wang, Jinying Ge, Xijun Wang, Zhigao Bu, Jinliang Wang

Journal: J Virol

PubMed ID: 36779762

Doi: 10.1128/jvi.01612-22

Products & Services: Proteins, Expression, Isolation and Analysis

Application of an electro elution system for direct purification of linear covalently closed DNA fragments

Authors: F Talebnia, D Pushparajah, S Chandrasekaran, S J Hersch, N Nafissi, R Slavcev

Journal: J Chromatogr B Analyt Technol Biomed Life Sci

PubMed ID: 36842293

Doi: 10.1016/j.jchromb.2023.123622

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De novo assembled transcriptomics assisted label-free quantitative proteomics analysis reveals sex-specific proteins in the intestinal tissue of Haemaphysalis qinghaiensis

Authors: Hejia Ma, Eloiza May Galon, Yanjun Lao, Ming Kang, Xuenan Xuan, Jixu Li, Yali Sun

Journal: Infect Genet Evol

PubMed ID: 36773671

Doi: 10.1016/j.meegid.2023.105409

Products & Services: PCR Cloning and Subcloning

Reaction intensification for biocatalytic production of polyphenolic natural product di-C-β-glucosides

Authors: Tuo Li, Annika J E Borg, Leo Krammer, Rolf Breinbauer, Bernd Nidetzky

Journal: Biotechnol Bioeng

PubMed ID: 36787984

Doi: 10.1002/bit.28354

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The cytoplasmic synthesis and coupled membrane translocation of eukaryotic polyphosphate by signal-activated VTC complex

Authors: Zeyuan Guan, Juan Chen, Ruiwen Liu, Yanke Chen, Qiong Xing, Zhangmeng Du, Meng Cheng, Jianjian Hu, Wenhui Zhang, Wencong Mei, Beijing Wan, Qiang Wang, Jie Zhang, Peng Cheng, Huanyu Cai, Jianbo Cao, Delin Zhang, Junjie Yan, Ping Yin, Michael Hothorn, Zhu Liu

Journal: Nat Commun

PubMed ID: 36759618

Doi: 10.1038/s41467-023-36466-4

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Chromium exposure altered metabolome and microbiome-associated with neurotoxicity in zebrafish

Authors: Tongtong Yan, Yawen Xu, Yuqi Zhu, Ping Jiang, Zhan Zhang, Lei Li, Qian Wu

Journal: J Appl Toxicol

PubMed ID: 36727205

Doi: 10.1002/jat.4440

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Delivery of spike-RBD by bacterial type three secretion system for SARS-CoV-2 vaccine development

Authors: Yuchen Zhou, Jing Qu, Xiaomeng Sun, Zhuo Yue, Yingzi Liu, Keli Zhao, Fan Yang, Jie Feng, Xiaolei Pan, Yongxin Jin, Zhihui Cheng, Liang Yang, Un-Hwan Ha, Weihui Wu, Liang Li, Fang Bai

Journal: Front Immunol

PubMed ID: 36895557

Doi: 10.3389/fimmu.2023.1129705

Products & Services: Recombinant Proteins

Fragment-Based Phasing of Peptidic Nanocrystals by MicroED

Authors: Logan S Richards, Maria D Flores, Claudia Millán, Calina Glynn, Chih-Te Zee, Michael R Sawaya, Marcus Gallagher-Jones, Rafael J Borges, Isabel Usón, Jose A Rodriguez

Journal: ACS Bio Med Chem Au

PubMed ID: 37096030

Doi: 10.1021/acsbiomedchemau.2c00082

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The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread

Authors: A C Gomes, I A Baraniak, A Lankina, Z Moulder, P Holenya, C Atkinson, G Tang, T Mahungu, F Kern, P D Griffiths, M B Reeves

Journal: Nat Commun

PubMed ID: 36823200

Doi: 10.1038/s41467-023-36683-x

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Analysis of Bacterial Microcompartments and Shell Protein Superstructures by Confocal Microscopy

Authors: Daniel S Trettel, Wade C Winkler

Journal: Microbiol Spectr

PubMed ID: 36786617

Doi: 10.1128/spectrum.03357-22

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Mindin Activates Autophagy for Lipid Utilization and Facilitates White Spot Syndrome Virus Infection in Shrimp

Authors: Jie Gao, Ye-Jia Song, Hao Wang, Bao-Rui Zhao, Xian-Wei Wang

Journal: MBio

PubMed ID: 36779788

Doi: 10.1128/mbio.02919-22

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N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy

Authors: Hidehiko Okuma, Jeffrey M Hord, Ishita Chandel, David Venzke, Mary E Anderson, Ameya S Walimbe, Soumya Joseph, Zeita Gastel, Yuji Hara, Fumiaki Saito, Kiichiro Matsumura, Kevin P Campbell

Journal: Elife

PubMed ID: 36723429

Doi: 10.7554/eLife.82811

Products & Services: Combinatorial DNA Libraries

Identifying CDC7 as a synergistic target of chemotherapy in resistant small-cell lung cancer via CRISPR/Cas9 screening

Authors: Ling Deng, Li Yang, Shuhan Zhu, Man Li, Yu Wang, Xiaolong Cao, Qiongyao Wang, Linlang Guo

Journal: Cell Death Discov

PubMed ID: 36725843

Doi: 10.1038/s41420-023-01315-2

Products & Services: Molecular Biology Reagents

Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes

Authors: Amanda Fabra-García, Sophia Hailemariam, Roos M de Jong, Kirsten Janssen, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Danton Ivanochko, Anthony Semesi, Brandon McLeod, Martijn W Vos, Marloes H C de Bruijni, Judith M Bolscher, Marta Szabat, Stefanie Vogt, Lucas Kraft, Sherie Duncan, Moses R Kamya, Margaret E Feeney, Prasanna Jagannathan, Bryan Greenhouse, Koen J Dechering, Robert W Sauerwein, C Richter King, Randall S MacGill, Teun Bousema, Jean-Philippe Julien, Matthijs M Jore

Journal: Immunity

PubMed ID: 36792574

Doi: 10.1016/j.immuni.2023.01.009

Products & Services: Proteins, Expression, Isolation and Analysis

Cas9-orthologue-mediated cytosine and adenine base editors recognizing NNAAAA PAM sequences

Authors: Min Li, Yuting Zhao, Xiaowen Xue, Jingli Zhong, Jianxiang Lin, Jiankui Zhou, Wenhua Yu, Jun Chen, Yunbo Qiao

Journal: Biotechnol J

PubMed ID: 36800529

Doi: 10.1002/biot.202200533

Products & Services: Proteins, Expression, Isolation and Analysis

Using a modified piggyBac transposon-combined Cre/loxP system to produce selectable reporter-free transgenic bovine mammary epithelial cells for somatic cell nuclear transfer

Authors: Guangdong Hu, Meijun Song, Yan Wang, Kexing Hao, Jing Wang, Yong Zhang

Journal: Genesis

PubMed ID: 36748563

Doi: 10.1002/dvg.23510

Products & Services: Proteins, Expression, Isolation and Analysis

Recombinant vesicular stomatitis virus-vectored vaccine induces long-lasting immunity against Nipah virus disease

Authors: Courtney Woolsey, Viktoriya Borisevich, Alyssa C Fears, Krystle N Agans, Daniel J Deer, Abhishek N Prasad, Rachel O'Toole, Stephanie L Foster, Natalie S Dobias, Joan B Geisbert, Karla A Fenton, Robert W Cross, Thomas W Geisbert

Journal: J Clin Invest

PubMed ID: 36445779

Doi: 10.1172/JCI164946

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Chimeric Hepatitis B core virus-like particles harboring SARS-CoV2 epitope elicit a humoral immune response in mice

Authors: Sima Sazegari, Malihe Akbarzadeh Niaki, Alireza Afsharifar, Ali Niazi, Abdollah Derakhshandeh, Maryam Moradi Vahdat, Farshad Hemmati, Mohammad Hadi Eskandari

Journal: Microb Cell Fact

PubMed ID: 36841778

Doi: 10.1186/s12934-023-02043-z

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Evaluate the guide RNA effectiveness -mediated transient assays in

Authors: Zhibo Wang, Zachary Shea, Qi Li, Kunru Wang, Kerri Mills, Bo Zhang, Bingyu Zhao

Journal: Front Plant Sci

PubMed ID: 36890894

Doi: 10.3389/fpls.2023.1111683

Products & Services: Proteins, Expression, Isolation and Analysis

Whole genome sequencing of Malaysian colorectal cancer patients reveals specific druggable somatic mutations

Authors: Ryia Illani Mohd Yunos, Nurul-Syakima Ab Mutalib, Jia-Shiun Khoo, Sazuita Saidin, Muhiddin Ishak, Saiful Effendi Syafruddin, Francis Yew Fu Tieng, Najwa Farhah Md Yusof, Mohd Ridhwan Abd Razak, Norshahidah Mahamad Nadzir, Nadiah Abu, Isa Md Rose, Ismail Sagap, Luqman Mazlan, Rahman Jamal

Journal: Front Mol Biosci

PubMed ID: 36866106

Doi: 10.3389/fmolb.2022.997747

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DhFIG_2, a gene of nematode-trapping fungus Dactylellina haptotyla that encodes a component of the low-affinity calcium uptake system, is required for conidiation and knob-trap formation

Authors: Xiaozhou Zhao, Yani Fan, Weiwei Zhang, Meichun Xiang, Seogchan Kang, Shunxian Wang, Xingzhong Liu

Journal: Fungal Genet Biol

PubMed ID: 36849068

Doi: 10.1016/j.fgb.2023.103782

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Lipid-induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells

Authors: Eshani Karmakar, Nabanita Das, Bidisha Mukherjee, Prosenjit Das, Satinath Mukhopadhyay, Sib Sankar Roy

Journal: Biochem Cell Biol

PubMed ID: 36787544

Doi: 10.1139/bcb-2022-0266

Products & Services: PCR Cloning and Subcloning

BioID2 screening identifies KIAA1671 as an EPS8 proximal factor that marks sites of microvillus growth

Authors: Isabella M Gaeta, Matthew J Tyska

Journal: Mol Biol Cell

PubMed ID: 36790915

Doi: 10.1091/mbc.E22-11-0498

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Function of the bacteriophage P2 baseplate central spike Apex domain in the infection process

Authors: John-Mark Miller, Ekaterina S Knyazhanskaya, Sergii A Buth, Nikolai S Prokhorov, Petr G Leiman

Journal: biorxiv

PubMed ID: 36865152

Doi: 10.1101/2023.02.25.529910

Products & Services: Proteins, Expression, Isolation and Analysis

Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment

Authors: Robin M Hallett, Ester Bonfill-Teixidor, Raffaella Iurlaro, Alexandra Arias, Swetha Raman, Peter Bayliss, Olga Egorova, Almudena Neva-Alejo, Aj Robert McGray, Esther Lau, Alexandre Bosch, Melissa Beilschmidt, Dorothea Maetzel, Johan Fransson, Isabel Huber-Ruano, Judit Anido, Jean-Philippe Julien, Patricia Giblin, Joan Seoane

Journal: Clin Cancer Res

PubMed ID: 36441800

Doi: 10.1158/1078-0432.CCR-21-1888

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Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury

Authors: Jie Chang, Zhanyang Qian, Binyu Wang, Jiang Cao, Sheng Zhang, Fan Jiang, Renyi Kong, Xiao Yu, Xiaojian Cao, Lei Yang, Hongtao Chen

Journal: Cell Commun Signal

PubMed ID: 36797790

Doi: 10.1186/s12964-022-01036-6

Products & Services: Proteins, Expression, Isolation and Analysis

Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapy

Authors: Natalia Plewa, Lucia Poncette, Thomas Blankenstein

Journal: J Immunother Cancer

PubMed ID: 36822673

Doi: 10.1136/jitc-2022-006001

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The SpACE-CCM: A facile and versatile cell culture medium-based biosensor for detection of SARS-CoV-2 spike-ACE2 interaction

Authors: Youngwook Ham, Nam-Chul Cho, Daeyong Kim, Jung-Hee Kim, Min Ju Jo, Min Seon Jeong, Bo-Yeong Pak, Sanghyeok Lee, Mi-Kyung Lee, Seung-Wook Chi, Tae-Don Kim, Nak Cheol Jeong, Sungchan Cho

Journal: Biosens Bioelectron

PubMed ID: 36827795

Doi: 10.1016/j.bios.2023.115169

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Tuning the Microenvironment to Create Functionally Distinct Mesenchymal Stromal Cell Spheroids

Authors: Victoria L Thai, Diego O Candelas, J Kent Leach

Journal: Ann Biomed Eng

PubMed ID: 36809393

Doi: 10.1007/s10439-023-03162-9

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Non-specific and specific DNA binding modes of bacterial histone, HU, separately regulate distinct physiological processes through different mechanisms

Authors: Subhash C Verma, Adam Harned, Kedar Narayan, Sankar Adhya

Journal: Mol Microbiol

PubMed ID: 36708073

Doi: 10.1111/mmi.15033

Products & Services: Proteins, Expression, Isolation and Analysis

Design of a Tumor Binding GMCSF as Intratumoral Immunotherapy of Solid Tumors

Authors: Aparna Raghavachar Chakravarti, Chad E Groer, Huan Gong, Vivian Yudistyra, Marcus Laird Forrest, Cory J Berkland

Journal: Mol Pharm

PubMed ID: 36825806

Doi: 10.1021/acs.molpharmaceut.2c00897

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CYCLIN-DEPENDENT KINASE 8 positively regulates oil synthesis by activating WRINKLED1 transcription

Authors: Zhiyang Zhai, Jantana K Blanford, Yingqi Cai, Jing Sun, Hui Liu, Hai Shi, Jorg Schwender, John Shanklin

Journal: New Phytol

PubMed ID: 36683527

Doi: 10.1111/nph.18764

Products & Services: Monoclonal Antibody Services

pH-Sensitive and Biodegradable Mn3(PO4)2·3H2O Nanoparticles as an Adjuvant of Protein-Based Bivalent COVID-19 Vaccine to Induce Potent and Broad-Spectrum Immunity

Authors: Shi-Hao Zhou,‡Ru-Yan Zhang,Zi-Wei You, Yong-Ke Zou, Yu Wen, Jian Wang, Dong Ding, Miao-Miao Bian, Zhi-Ming Zhang, Hong Yuan, Guang-Fu Yang, and Jun Guo

Journal: ACS Applied Materials & Interfaces

Doi: 10.1021/acsami.2c19736

Products & Services: Recombinant Proteins

A novel binary pesticidal protein from Chryseobacterium arthrosphaerae controls western corn rootworm by a different mode of action to existing commercial pesticidal proteins

Authors: Rania Jabeur, Virginie Guyon, Szabolcs Toth, Adriano E Pereira, Man P Huynh, Zakia Selmani, Erin Boland, Mickael Bosio, Laurent Beuf, Pete Clark, David Vallenet, Wafa Achouak, Carine Audiffrin, François Torney, Wyatt Paul, Thierry Heulin, Bruce E Hibbard, Stefan Toepfer, Christophe Sallaud

Journal: PLoS ONE

PubMed ID: 36800363

Doi: 10.1371/journal.pone.0267220

Products & Services: Proteins, Expression, Isolation and Analysis

Mechanistic Basis for a Connection between the Catalytic Step and Slow Opening Dynamics of Adenylate Kinase

Authors: Beata Dulko-Smith, Pedro Ojeda-May, Jörgen Ådén, Magnus Wolf-Watz, Kwangho Nam

Journal: J Chem Inf Model

PubMed ID: 36802243

Doi: 10.1021/acs.jcim.2c01629

Products & Services: Proteins, Expression, Isolation and Analysis

Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease

Authors: Raaj S Mehta, Jared R Mayers, Yancong Zhang, Amrisha Bhosle, Nathaniel R Glasser, Long H Nguyen, Wenjie Ma, Sena Bae, Tobyn Branck, Kijun Song, Luke Sebastian, Julian Avila Pacheco, Hyuk-Soo Seo, Clary Clish, Sirano Dhe-Paganon, Ashwin N Ananthakrishnan, Eric A Franzosa, Emily P Balskus, Andrew T Chan, Curtis Huttenhower

Journal: Nat Med

PubMed ID: 36823301

Doi: 10.1038/s41591-023-02217-7

Products & Services: Proteins, Expression, Isolation and Analysis

Exocytic machineries differentially control mediator release from allergen-triggered RBL-2H3 cells

Authors: Pratikshya Adhikari, Tolulope E Ayo, John C Vines, Shuzo Sugita, Hao Xu

Journal: Inflamm Res

PubMed ID: 36725743

Doi: 10.1007/s00011-023-01698-z

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Mechanism of inhibition of CRISPR-Cas9 by anti-CRISPR protein AcrIIC1

Authors: Yalan Zhu, Sen Yin, Zhao Li

Journal: Biochem Biophys Res Commun

PubMed ID: 36878037

Doi: 10.1016/j.bbrc.2023.02.065

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Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants

Authors: Haisheng Yu, Banghui Liu, Yudi Zhang, Xijie Gao, Qian Wang, Haitao Xiang, Xiaofang Peng, Caixia Xie, Yaping Wang, Peiyu Hu, Jingrong Shi, Quan Shi, Pingqian Zheng, Chengqian Feng, Guofang Tang, Xiaopan Liu, Liliangzi Guo, Xiumei Lin, Jiaojiao Li, Chuanyu Liu, Yaling Huang, Naibo Yang, Qiuluan Chen, Zimu Li, Mengzhen Su, Qihong Yan, Rongjuan Pei, Xinwen Chen, Longqi Liu, Fengyu Hu, Dan Liang, Bixia Ke, Changwen Ke, Feng Li, Jun He, Meiniang Wang, Ling Chen, Xiaoli Xiong, Xiaoping Tang

Journal: Nat Commun

PubMed ID: 36828833

Doi: 10.1038/s41467-023-36761-0

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Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase

Authors: Nadine T Werner, Philipp Högel, Gökhan Güner, Walter Stelzer, Manfred Wozny, Marlene Aßfalg, Stefan F Lichtenthaler, Harald Steiner, Dieter Langosch

Journal: Commun Biol

PubMed ID: 36792683

Doi: 10.1038/s42003-023-04470-5

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Expression, purification, and characterisation of the p53 binding domain of Retinoblastoma binding protein 6 (RBBP6)

Authors: Bonnie L Russell, Monde Ntwasa

Journal: PLoS ONE

PubMed ID: 36763571

Doi: 10.1371/journal.pone.0277478

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LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway

Authors: Sijia Han, Xueying Jin, Tianyu Hu, Feng Chi

Journal: Oncol Rep

PubMed ID: 36799186

Doi: 10.3892/or.2023.8497

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ACE2 binding and antibody evasion in enhanced transmissibility of XBB15

Authors: Can Yue, Weiliang Song, Lei Wang, Fanchong Jian, Xiaosu Chen, Fei Gao, Zhongyang Shen, Youchun Wang, Xiangxi Wang, Yunlong Cao

Journal: Lancet Infect Dis

PubMed ID: 36746173

Doi: 10.1016/S1473-3099(23)00010-5

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MTORC2 is a physiological hydrophobic motif kinase of S6 Kinase 1

Authors: Sheikh Tahir Majeed, Rabiya Majeed, Aijaz A Malik, Khurshid Iqbal Andrabi

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 36858209

Doi: 10.1016/j.bbamcr.2023.119449

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A Physiologically Responsive Nanocomposite Hydrogel for Treatment of Head and Neck Squamous Cell Carcinoma via Proteolysis-Targeting Chimeras Enhanced Immunotherapy

Authors: Yaping Wu, Xiaowei Chang, Guizhu Yang, Li Chen, Qi Wu, Jiamin Gao, Ran Tian, Wenyun Mu, John Justin Gooding, Xin Chen, Shuyang Sun

Journal: Adv Mater

PubMed ID: 36656993

Doi: 10.1002/adma.202210787

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Functionalized biomimetic nanoparticles combining programmed death-1/programmed death-ligand 1 blockade with photothermal ablation for enhanced colorectal cancer immunotherapy.

Authors: Yuchen Xiao, Tianchuan Zhu, Qi Zeng, Qingqin Tan, Guanmin Jiang, Xi Huang

Journal: Acta Biomater

PubMed ID: 36442821

Doi: 10.1016/j.actbio.2022.11.043

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SARS-CoV-2 Main Protease Targets Host Selenoproteins and Glutathione Biosynthesis for Knockdown via Proteolysis, Potentially Disrupting the Thioredoxin and Glutaredoxin Redox Cycles

Authors: Ignacio A Gallardo, Daniel A Todd, Stella T Lima, Jonathan R Chekan, Norman H Chiu, Ethan Will Taylor

Journal: Antioxidants (Basel)

PubMed ID: 36978807

Doi: 10.3390/antiox12030559

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Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres

Authors: Radka Storchova, Matous Palek, Natalie Palkova, Pavel Veverka, Tomas Brom, Ctirad Hofr, Libor Macurek

Journal: Nucleic Acids Res

PubMed ID: 36651296

Doi: 10.1093/nar/gkac1269

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Chikungunya Virus and Its Envelope Protein E2 Induce Hyperalgesia in Mice: Inhibition by Anti-E2 Monoclonal Antibodies and by Targeting TRPV1

Authors: Carina Z Segato-Vendrameto, Camila Zanluca, Amanda Z Zucoloto, Tiago H Zaninelli, Mariana M Bertozzi, Telma Saraiva-Santos, Camila R Ferraz, Larissa Staurengo-Ferrari, Stephanie Badaro-Garcia, Marília F Manchope, Amanda M Dionisio, Felipe A Pinho-Ribeiro, Sergio M Borghi, Ana Luiza Pamplona Mosimann, Rubia Casagrande, Juliano Bordignon, Victor Fattori, Claudia N Duarte Dos Santos, Waldiceu A Verri

Journal: Cells

PubMed ID: 36831223

Doi: 10.3390/cells12040556

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How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member

Authors: Juan C Opazo, Michael W Vandewege, Federico G Hoffmann, Kattina Zavala, Catalina Meléndez, Charlotte Luchsinger, Viviana A Cavieres, Luis Vargas-Chacoff, Francisco J Morera, Patricia V Burgos, Cheril Tapia-Rojas, Gonzalo A Mardones

Journal: Mol Biol Evol

PubMed ID: 36656997

Doi: 10.1093/molbev/msad014

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Antagonism between Prdm16 and Smad4 specifies the trajectory and progression of pancreatic cancer

Authors: Eric Hurwitz, Parash Parajuli, Seval Ozkan, Celine Prunier, Thien Ly Nguyen, Deanna Campbell, Creighton Friend, Allyn Austin Bryan, Ting-Xuan Lu, Steven Christopher Smith, Mohammed Shawkat Razzaque, Keli Xu, Azeddine Atfi

Journal: J Cell Biol

PubMed ID: 36828547

Doi: 10.1083/jcb.202203036

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FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner

Authors: Yaguang Bi, Shuolin Liu, Xing Qin, Miyesaier Abudureyimu, Lu Wang, Rongjun Zou, Amir Ajoolabady, Wenjing Zhang, Hu Peng, Jun Ren, Yingmei Zhang

Journal: J Adv Res

PubMed ID: 36828120

Doi: 10.1016/j.jare.2023.02.012

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Revealing the role of tunable amino acid residues in elastin-like polypeptides (ELPs)-mediated biomimetic silicification

Authors: Yue Qiu , Yuanqing Lin , Bo Zeng , Peiliang Qin , Zhiwei Yi , Guangya Zhang

Journal: Int J Biol Macromol

PubMed ID: 36539170

Doi: 10.1016/j.ijbiomac.2022.12.152

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Microenvironment-responsive anti-PD-L1 × CD3 bispecific T-cell engager for solid tumor immunotherapy

Authors: Dingkang Liu, Lichen Bao, Haichao Zhu, Yali Yue, Jing Tian, Xiangdong Gao, Jun Yin

Journal: Journal of controlled release

PubMed ID: 36669532

Doi: 10.1016/j.jconrel.2023.01.041

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Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner

Authors: Yiru Long , Runqiu Chen , Xiaolu Yu , Yongliang Tong , Xionghua Peng , Fanglin Li , Chao Hu, Jianhua Sun , Likun Gong

Journal: Cancer Immunol Res .

PubMed ID: 36484740

Doi: 10.1158/2326-6066.CIR-22-0439

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A natriuretic peptide molecule from Vigna angularis, VaEG45, confers rust resistance by inhibiting fungal development

Authors: Weina Sun , Mengqi Yuan , Lihua Yin , Xiwang Ke , Yuhu Zuo

Journal: Plant Cell Rep .

PubMed ID: 36576553

Doi: 10.1007/s00299-022-02967-7

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Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations

Authors: Joseph H Garcia, Erin A Akins, Saket Jain, Kayla J Wolf, Jason Zhang, Nikita Choudhary, Meeki Lad, Poojan Shukla, Sabraj Gill, Will Carson, Luis Carette, Allison Zheng, Sanjay Kumar, Manish K Aghi

Journal: biorxiv

PubMed ID: 36865128

Doi: 10.1101/2023.02.23.529575

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Crystallographic data of an importin-α3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal

Authors:

Journal: Data Brief

PubMed ID: 36875212

Doi: 10.1016/j.dib.2023.108988

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Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice

Authors: Matthew T Birnie, Annabel K Short, Gregory B de Carvalho, Lara Taniguchi, Benjamin G Gunn, Aidan L Pham, Christy A Itoga, Xiangmin Xu, Lulu Y Chen, Stephen V Mahler, Yuncai Chen, Tallie Z Baram

Journal: Nat Commun

PubMed ID: 36841826

Doi: 10.1038/s41467-023-36780-x

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Retinoblastoma Expression and Targeting by CDK4/6 Inhibitors in Small Cell Lung Cancer

Authors: Gary Wildey, Ashley M Shay, Karen S McColl, Suzy Yoon, Mohammad A Shatat, Ahmad Perwez, Kyle B Spainhower, Adam M Kresak, MaryBeth Lipka, Michael Yang, Mohadese Behtaj, Pingfu Fu, Asrar Alahmadi, Wadad Mneimneh, Ata Abbas, Afshin Dowlati

Journal: Mol Cancer Ther

PubMed ID: 36399634

Doi: 10.1158/1535-7163.MCT-22-0365

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Time-Course Transcriptome Profiling Reveals Differential Resistance Responses of Tomato to a Phytotoxic Effector of the Pathogenic Oomycete

Authors: Xue Zhou, Ke Wen, Shen-Xin Huang, Yi Lu, Yang Liu, Jing-Hao Jin, Shiv D Kale, Xiao-Ren Chen

Journal: Plants (Basel)

PubMed ID: 36840230

Doi: 10.3390/plants12040883

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Establishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection

Authors: Pei-Fen Zhang, Zi-Yi Wu, Wen-Bin Zhang, Yong-Qiao He, Kexin Chen, Tong-Min Wang, Haixin Li, Hong Zheng, Dan-Hua Li, Da-Wei Yang, Ting Zhou, Chang-Mi Deng, Ying Liao, Wen-Qiong Xue, Lian-Jing Cao, Xi-Zhao Li, Jiang-Bo Zhang, Si-Qi Dong, Fang Wang, Mei-Qi Zheng, Wen-Li Zhang, Jianbing Mu, Wei-Hua Jia

Journal: Nat Commun

PubMed ID: 36746966

Doi: 10.1038/s41467-023-36374-7

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Enhancement of Cell Adhesion by Nucleolin-Interacting Protein AFAP

Authors: Hongcheng Tang, Daxiu Zhang, Fenfen Jiang, Lifeng Yu, Hui Tang, Jiafeng Zhu, Shuyan Wu, Hua Niu

Journal: J Pers Med

PubMed ID: 36836536

Doi: 10.3390/jpm13020302

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Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives

Authors: Yee Han Tee, Wei Jia Goh, Xianbin Yong, Hui Ting Ong, Jinrong Hu, Ignacius Yan Yun Tay, Shidong Shi, Salma Jalal, Samuel F H Barnett, Pakorn Kanchanawong, Wenmao Huang, Jie Yan, Yong Ann Ben Lim, Visalatchi Thiagarajan, Alex Mogilner, Alexander D Bershadsky

Journal: Nat Commun

PubMed ID: 36774346

Doi: 10.1038/s41467-023-35918-1

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A cercarial invadolysin interferes with the host immune response and facilitates infection establishment of Schistosoma mansoni

Authors: Jacob R Hambrook, Patrick C Hanington

Journal: PLoS Pathog

PubMed ID: 36730464

Doi: 10.1371/journal.ppat.1010884

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Selective excitation with recoupling pulse schemes uncover properties of disordered mineral phases in bone-like apatite grown with bone proteins

Authors: Irina Matlahov, Alexey Kulpanovich, Taly Iline-Vul, Merav Nadav-Tsubery, Gil Goobes

Journal: Solid State Nucl Magn Reson

PubMed ID: 36913847

Doi: 10.1016/j.ssnmr.2023.101860

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Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser

Authors: Rebecca J Jernigan , Dhenugen Logeswaran , Diandra Doppler , Nirupa Nagaratnam , Mukul Sonker , Jay-How Yang , Gihan Ketawala , Jose M Martin-Garcia , Megan L Shelby , Thomas D Grant , Valerio Mariani , Alexandra Tolstikova , Michelle Z Sheikh , Mimi Cho Yung , Matthew A Coleman , Sahba Zaare , Emily K Kaschner , Mohammad Towshif Rabbani , Reza Nazari , Michele A Zacks , Brandon Hayes , Raymond G Sierra , Mark S Hunter , Stella Lisova , Alexander Batyuk , Christopher Kupitz , Sebastien Boutet , Debra T Hansen , Richard A Kirian , Marius Schmidt , Raimund Fromme , Matthias Frank , Alexandra Ros , Julian J-L Chen , Sabine Botha , Petra Fromme

Journal: Structure.

PubMed ID: 36630960

Doi: 10.1016/j.str.2022.12.009

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Heteromultivalent scaffolds fabricated by biomimetic co-assembly of DNA-RNA building blocks for the multi-analysis of miRNAs

Authors: Chengjie Duan, Yan Chen, Zhiqiang Hou, Dayong Li, Jin Jiao, Weihao Sun, Yang Xiang

Journal: J Mater Chem B

PubMed ID: 36723144

Doi: 10.1039/d2tb02663e

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Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes

Authors: Yi Sun, Georgia F Papadaki, Christine A Devlin, Julia N Danon, Michael C Young, Trenton J Winters, George M Burslem, Erik Procko, Nikolaos G Sgourakis

Journal: Sci Adv

PubMed ID: 36827371

Doi: 10.1126/sciadv.ade7151

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Functional analysis of 110 phosphorylation sites on the circadian clock protein FRQ identifies clusters determining period length and temperature compensation

Authors: Bin Wang, Elizabeth-Lauren Stevenson, Jay C Dunlap

Journal: G3 (Bethesda)

PubMed ID: 36537198

Doi: 10.1093/g3journal/jkac334

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Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols

Authors: Calvin Dumesnil, Lauri Vanharanta, Xavier Prasanna, Mohyeddine Omrane, Maxime Carpentier, Apoorva Bhapkar, Giray Enkavi, Veijo T Salo, Ilpo Vattulainen, Elina Ikonen, Abdou Rachid Thiam

Journal: Nat Commun

PubMed ID: 36807572

Doi: 10.1038/s41467-023-36375-6

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Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease

Authors: Rui Zhao, Li Cao, Wen-Jun Gu, Lei Li, Zhong-Zhong Chen, Jie Xiang, Ze-Yu Zhou, Bo Xu, Wei-Dong Zang, Xiang-Yu Zhou, Jing Cao, Kun Sun, Jian-Yuan Zhao

Journal: Cell Rep Med

PubMed ID: 36809766

Doi: 10.1016/j.xcrm.2023.100953

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A midposition NOTCH3 truncation in inherited cerebral small vessel disease may affect the protein interactome

Authors: Soo Jung Lee , Xiaojie Zhang , Gang Xu , Jimo Borjigin , Michael M Wang

Journal: J Biol Chem .

PubMed ID: 36470429

Doi: 10.1016/j.jbc.2022.102772

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Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants

Authors: Saskia Meyer , Isaac Blaas , Ravi Chand Bollineni , Marina Delic-Sarac , Trung T Tran , Cathrine Knetter , Ke-Zheng Dai , Torfinn Støve Madssen , John T Vaage , Alice Gustavsen , Weiwen Yang , Lise Sofie Haug Nissen-Meyer , Karolos Douvlataniotis , Maarja Laos , Morten Milek Nielsen , Bernd Thiede , Arne Søraas , Fridtjof Lund-Johansen , Even H Rustad, Johanna Olweus

Journal: Cell Rep .

PubMed ID: 36656713

Doi: 10.1016/j.celrep.2023.111995

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Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor

Authors: Jia Duan , Peiyu Xu , Huibing Zhang , Xiaodong Luan , Jiaqi Yang, Xinheng He , Chunyou Mao , Dan-Dan Shen , Yujie Ji , Xi Cheng , Hualiang Jiang , Yi Jiang , Shuyang Zhang , Yan Zhang , H Eric Xu

Journal: Nat Commun .

PubMed ID: 36720854

Doi: 10.1038/s41467-023-36170-3

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