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Design of a Tumor Binding GMCSF as Intratumoral Immunotherapy of Solid Tumors

Authors: Aparna Raghavachar Chakravarti, Chad E Groer, Huan Gong, Vivian Yudistyra, Marcus Laird Forrest, Cory J Berkland

Journal: Mol Pharm

PubMed ID: 36825806

Doi: 10.1021/acs.molpharmaceut.2c00897

Products & Services: Gene Synthesis

CYCLIN-DEPENDENT KINASE 8 positively regulates oil synthesis by activating WRINKLED1 transcription

Authors: Zhiyang Zhai, Jantana K Blanford, Yingqi Cai, Jing Sun, Hui Liu, Hai Shi, Jorg Schwender, John Shanklin

Journal: New Phytol

PubMed ID: 36683527

Doi: 10.1111/nph.18764

Products & Services: Monoclonal Antibody Services

pH-Sensitive and Biodegradable Mn3(PO4)2·3H2O Nanoparticles as an Adjuvant of Protein-Based Bivalent COVID-19 Vaccine to Induce Potent and Broad-Spectrum Immunity

Authors: Shi-Hao Zhou,‡Ru-Yan Zhang,Zi-Wei You, Yong-Ke Zou, Yu Wen, Jian Wang, Dong Ding, Miao-Miao Bian, Zhi-Ming Zhang, Hong Yuan, Guang-Fu Yang, and Jun Guo

Journal: ACS Applied Materials & Interfaces

Doi: 10.1021/acsami.2c19736

Products & Services: Recombinant Proteins

A novel binary pesticidal protein from Chryseobacterium arthrosphaerae controls western corn rootworm by a different mode of action to existing commercial pesticidal proteins

Authors: Rania Jabeur, Virginie Guyon, Szabolcs Toth, Adriano E Pereira, Man P Huynh, Zakia Selmani, Erin Boland, Mickael Bosio, Laurent Beuf, Pete Clark, David Vallenet, Wafa Achouak, Carine Audiffrin, François Torney, Wyatt Paul, Thierry Heulin, Bruce E Hibbard, Stefan Toepfer, Christophe Sallaud

Journal: PLoS ONE

PubMed ID: 36800363

Doi: 10.1371/journal.pone.0267220

Products & Services: Proteins, Expression, Isolation and Analysis

Mechanistic Basis for a Connection between the Catalytic Step and Slow Opening Dynamics of Adenylate Kinase

Authors: Beata Dulko-Smith, Pedro Ojeda-May, Jörgen Ådén, Magnus Wolf-Watz, Kwangho Nam

Journal: J Chem Inf Model

PubMed ID: 36802243

Doi: 10.1021/acs.jcim.2c01629

Products & Services: Proteins, Expression, Isolation and Analysis

Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease

Authors: Raaj S Mehta, Jared R Mayers, Yancong Zhang, Amrisha Bhosle, Nathaniel R Glasser, Long H Nguyen, Wenjie Ma, Sena Bae, Tobyn Branck, Kijun Song, Luke Sebastian, Julian Avila Pacheco, Hyuk-Soo Seo, Clary Clish, Sirano Dhe-Paganon, Ashwin N Ananthakrishnan, Eric A Franzosa, Emily P Balskus, Andrew T Chan, Curtis Huttenhower

Journal: Nat Med

PubMed ID: 36823301

Doi: 10.1038/s41591-023-02217-7

Products & Services: Proteins, Expression, Isolation and Analysis

Exocytic machineries differentially control mediator release from allergen-triggered RBL-2H3 cells

Authors: Pratikshya Adhikari, Tolulope E Ayo, John C Vines, Shuzo Sugita, Hao Xu

Journal: Inflamm Res

PubMed ID: 36725743

Doi: 10.1007/s00011-023-01698-z

Products & Services: Proteins, Expression, Isolation and Analysis

Mechanism of inhibition of CRISPR-Cas9 by anti-CRISPR protein AcrIIC1

Authors: Yalan Zhu, Sen Yin, Zhao Li

Journal: Biochem Biophys Res Commun

PubMed ID: 36878037

Doi: 10.1016/j.bbrc.2023.02.065

Products & Services: Molecular Biology Reagents

Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants

Authors: Haisheng Yu, Banghui Liu, Yudi Zhang, Xijie Gao, Qian Wang, Haitao Xiang, Xiaofang Peng, Caixia Xie, Yaping Wang, Peiyu Hu, Jingrong Shi, Quan Shi, Pingqian Zheng, Chengqian Feng, Guofang Tang, Xiaopan Liu, Liliangzi Guo, Xiumei Lin, Jiaojiao Li, Chuanyu Liu, Yaling Huang, Naibo Yang, Qiuluan Chen, Zimu Li, Mengzhen Su, Qihong Yan, Rongjuan Pei, Xinwen Chen, Longqi Liu, Fengyu Hu, Dan Liang, Bixia Ke, Changwen Ke, Feng Li, Jun He, Meiniang Wang, Ling Chen, Xiaoli Xiong, Xiaoping Tang

Journal: Nat Commun

PubMed ID: 36828833

Doi: 10.1038/s41467-023-36761-0

Products & Services: Recombinant Antibody Expression

Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase

Authors: Nadine T Werner, Philipp Högel, Gökhan Güner, Walter Stelzer, Manfred Wozny, Marlene Aßfalg, Stefan F Lichtenthaler, Harald Steiner, Dieter Langosch

Journal: Commun Biol

PubMed ID: 36792683

Doi: 10.1038/s42003-023-04470-5

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Expression, purification, and characterisation of the p53 binding domain of Retinoblastoma binding protein 6 (RBBP6)

Authors: Bonnie L Russell, Monde Ntwasa

Journal: PLoS ONE

PubMed ID: 36763571

Doi: 10.1371/journal.pone.0277478

Products & Services: Proteins, Expression, Isolation and Analysis

LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway

Authors: Sijia Han, Xueying Jin, Tianyu Hu, Feng Chi

Journal: Oncol Rep

PubMed ID: 36799186

Doi: 10.3892/or.2023.8497

Products & Services: Stable Cell Lines

ACE2 binding and antibody evasion in enhanced transmissibility of XBB15

Authors: Can Yue, Weiliang Song, Lei Wang, Fanchong Jian, Xiaosu Chen, Fei Gao, Zhongyang Shen, Youchun Wang, Xiangxi Wang, Yunlong Cao

Journal: Lancet Infect Dis

PubMed ID: 36746173

Doi: 10.1016/S1473-3099(23)00010-5

Products & Services: Proteins, Expression, Isolation and Analysis

MTORC2 is a physiological hydrophobic motif kinase of S6 Kinase 1

Authors: Sheikh Tahir Majeed, Rabiya Majeed, Aijaz A Malik, Khurshid Iqbal Andrabi

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 36858209

Doi: 10.1016/j.bbamcr.2023.119449

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A Physiologically Responsive Nanocomposite Hydrogel for Treatment of Head and Neck Squamous Cell Carcinoma via Proteolysis-Targeting Chimeras Enhanced Immunotherapy

Authors: Yaping Wu, Xiaowei Chang, Guizhu Yang, Li Chen, Qi Wu, Jiamin Gao, Ran Tian, Wenyun Mu, John Justin Gooding, Xin Chen, Shuyang Sun

Journal: Adv Mater

PubMed ID: 36656993

Doi: 10.1002/adma.202210787

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Functionalized biomimetic nanoparticles combining programmed death-1/programmed death-ligand 1 blockade with photothermal ablation for enhanced colorectal cancer immunotherapy.

Authors: Yuchen Xiao, Tianchuan Zhu, Qi Zeng, Qingqin Tan, Guanmin Jiang, Xi Huang

Journal: Acta Biomater

PubMed ID: 36442821

Doi: 10.1016/j.actbio.2022.11.043

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 Main Protease Targets Host Selenoproteins and Glutathione Biosynthesis for Knockdown via Proteolysis, Potentially Disrupting the Thioredoxin and Glutaredoxin Redox Cycles

Authors: Ignacio A Gallardo, Daniel A Todd, Stella T Lima, Jonathan R Chekan, Norman H Chiu, Ethan Will Taylor

Journal: Antioxidants (Basel)

PubMed ID: 36978807

Doi: 10.3390/antiox12030559

Products & Services: Proteins, Expression, Isolation and Analysis

Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres

Authors: Radka Storchova, Matous Palek, Natalie Palkova, Pavel Veverka, Tomas Brom, Ctirad Hofr, Libor Macurek

Journal: Nucleic Acids Res

PubMed ID: 36651296

Doi: 10.1093/nar/gkac1269

Products & Services: Peptide Synthesis

Chikungunya Virus and Its Envelope Protein E2 Induce Hyperalgesia in Mice: Inhibition by Anti-E2 Monoclonal Antibodies and by Targeting TRPV1

Authors: Carina Z Segato-Vendrameto, Camila Zanluca, Amanda Z Zucoloto, Tiago H Zaninelli, Mariana M Bertozzi, Telma Saraiva-Santos, Camila R Ferraz, Larissa Staurengo-Ferrari, Stephanie Badaro-Garcia, Marília F Manchope, Amanda M Dionisio, Felipe A Pinho-Ribeiro, Sergio M Borghi, Ana Luiza Pamplona Mosimann, Rubia Casagrande, Juliano Bordignon, Victor Fattori, Claudia N Duarte Dos Santos, Waldiceu A Verri

Journal: Cells

PubMed ID: 36831223

Doi: 10.3390/cells12040556

Products & Services: Codon Optimization

How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member

Authors: Juan C Opazo, Michael W Vandewege, Federico G Hoffmann, Kattina Zavala, Catalina Meléndez, Charlotte Luchsinger, Viviana A Cavieres, Luis Vargas-Chacoff, Francisco J Morera, Patricia V Burgos, Cheril Tapia-Rojas, Gonzalo A Mardones

Journal: Mol Biol Evol

PubMed ID: 36656997

Doi: 10.1093/molbev/msad014

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Antagonism between Prdm16 and Smad4 specifies the trajectory and progression of pancreatic cancer

Authors: Eric Hurwitz, Parash Parajuli, Seval Ozkan, Celine Prunier, Thien Ly Nguyen, Deanna Campbell, Creighton Friend, Allyn Austin Bryan, Ting-Xuan Lu, Steven Christopher Smith, Mohammed Shawkat Razzaque, Keli Xu, Azeddine Atfi

Journal: J Cell Biol

PubMed ID: 36828547

Doi: 10.1083/jcb.202203036

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FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner

Authors: Yaguang Bi, Shuolin Liu, Xing Qin, Miyesaier Abudureyimu, Lu Wang, Rongjun Zou, Amir Ajoolabady, Wenjing Zhang, Hu Peng, Jun Ren, Yingmei Zhang

Journal: J Adv Res

PubMed ID: 36828120

Doi: 10.1016/j.jare.2023.02.012

Products & Services: Recombinant Proteins

Revealing the role of tunable amino acid residues in elastin-like polypeptides (ELPs)-mediated biomimetic silicification

Authors: Yue Qiu , Yuanqing Lin , Bo Zeng , Peiliang Qin , Zhiwei Yi , Guangya Zhang

Journal: Int J Biol Macromol

PubMed ID: 36539170

Doi: 10.1016/j.ijbiomac.2022.12.152

Products & Services: Gene Synthesis

Microenvironment-responsive anti-PD-L1 × CD3 bispecific T-cell engager for solid tumor immunotherapy

Authors: Dingkang Liu, Lichen Bao, Haichao Zhu, Yali Yue, Jing Tian, Xiangdong Gao, Jun Yin

Journal: Journal of controlled release

PubMed ID: 36669532

Doi: 10.1016/j.jconrel.2023.01.041

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Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner

Authors: Yiru Long , Runqiu Chen , Xiaolu Yu , Yongliang Tong , Xionghua Peng , Fanglin Li , Chao Hu, Jianhua Sun , Likun Gong

Journal: Cancer Immunol Res .

PubMed ID: 36484740

Doi: 10.1158/2326-6066.CIR-22-0439

Products & Services: Recombinant Proteins

A natriuretic peptide molecule from Vigna angularis, VaEG45, confers rust resistance by inhibiting fungal development

Authors: Weina Sun , Mengqi Yuan , Lihua Yin , Xiwang Ke , Yuhu Zuo

Journal: Plant Cell Rep .

PubMed ID: 36576553

Doi: 10.1007/s00299-022-02967-7

Products & Services: Peptide Synthesis

Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations

Authors: Joseph H Garcia, Erin A Akins, Saket Jain, Kayla J Wolf, Jason Zhang, Nikita Choudhary, Meeki Lad, Poojan Shukla, Sabraj Gill, Will Carson, Luis Carette, Allison Zheng, Sanjay Kumar, Manish K Aghi

Journal: biorxiv

PubMed ID: 36865128

Doi: 10.1101/2023.02.23.529575

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Crystallographic data of an importin-α3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal

Authors:

Journal: Data Brief

PubMed ID: 36875212

Doi: 10.1016/j.dib.2023.108988

Products & Services: Proteins, Expression, Isolation and Analysis

Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice

Authors: Matthew T Birnie, Annabel K Short, Gregory B de Carvalho, Lara Taniguchi, Benjamin G Gunn, Aidan L Pham, Christy A Itoga, Xiangmin Xu, Lulu Y Chen, Stephen V Mahler, Yuncai Chen, Tallie Z Baram

Journal: Nat Commun

PubMed ID: 36841826

Doi: 10.1038/s41467-023-36780-x

Products & Services: Proteins, Expression, Isolation and Analysis

Retinoblastoma Expression and Targeting by CDK4/6 Inhibitors in Small Cell Lung Cancer

Authors: Gary Wildey, Ashley M Shay, Karen S McColl, Suzy Yoon, Mohammad A Shatat, Ahmad Perwez, Kyle B Spainhower, Adam M Kresak, MaryBeth Lipka, Michael Yang, Mohadese Behtaj, Pingfu Fu, Asrar Alahmadi, Wadad Mneimneh, Ata Abbas, Afshin Dowlati

Journal: Mol Cancer Ther

PubMed ID: 36399634

Doi: 10.1158/1535-7163.MCT-22-0365

Products & Services: Molecular Biology Reagents

Time-Course Transcriptome Profiling Reveals Differential Resistance Responses of Tomato to a Phytotoxic Effector of the Pathogenic Oomycete

Authors: Xue Zhou, Ke Wen, Shen-Xin Huang, Yi Lu, Yang Liu, Jing-Hao Jin, Shiv D Kale, Xiao-Ren Chen

Journal: Plants (Basel)

PubMed ID: 36840230

Doi: 10.3390/plants12040883

Products & Services: Proteins, Expression, Isolation and Analysis

Establishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection

Authors: Pei-Fen Zhang, Zi-Yi Wu, Wen-Bin Zhang, Yong-Qiao He, Kexin Chen, Tong-Min Wang, Haixin Li, Hong Zheng, Dan-Hua Li, Da-Wei Yang, Ting Zhou, Chang-Mi Deng, Ying Liao, Wen-Qiong Xue, Lian-Jing Cao, Xi-Zhao Li, Jiang-Bo Zhang, Si-Qi Dong, Fang Wang, Mei-Qi Zheng, Wen-Li Zhang, Jianbing Mu, Wei-Hua Jia

Journal: Nat Commun

PubMed ID: 36746966

Doi: 10.1038/s41467-023-36374-7

Products & Services: Proteins, Expression, Isolation and Analysis

Enhancement of Cell Adhesion by Nucleolin-Interacting Protein AFAP

Authors: Hongcheng Tang, Daxiu Zhang, Fenfen Jiang, Lifeng Yu, Hui Tang, Jiafeng Zhu, Shuyan Wu, Hua Niu

Journal: J Pers Med

PubMed ID: 36836536

Doi: 10.3390/jpm13020302

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Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives

Authors: Yee Han Tee, Wei Jia Goh, Xianbin Yong, Hui Ting Ong, Jinrong Hu, Ignacius Yan Yun Tay, Shidong Shi, Salma Jalal, Samuel F H Barnett, Pakorn Kanchanawong, Wenmao Huang, Jie Yan, Yong Ann Ben Lim, Visalatchi Thiagarajan, Alex Mogilner, Alexander D Bershadsky

Journal: Nat Commun

PubMed ID: 36774346

Doi: 10.1038/s41467-023-35918-1

Products & Services: Proteins, Expression, Isolation and Analysis

A cercarial invadolysin interferes with the host immune response and facilitates infection establishment of Schistosoma mansoni

Authors: Jacob R Hambrook, Patrick C Hanington

Journal: PLoS Pathog

PubMed ID: 36730464

Doi: 10.1371/journal.ppat.1010884

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Selective excitation with recoupling pulse schemes uncover properties of disordered mineral phases in bone-like apatite grown with bone proteins

Authors: Irina Matlahov, Alexey Kulpanovich, Taly Iline-Vul, Merav Nadav-Tsubery, Gil Goobes

Journal: Solid State Nucl Magn Reson

PubMed ID: 36913847

Doi: 10.1016/j.ssnmr.2023.101860

Products & Services: Proteins, Expression, Isolation and Analysis

Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser

Authors: Rebecca J Jernigan , Dhenugen Logeswaran , Diandra Doppler , Nirupa Nagaratnam , Mukul Sonker , Jay-How Yang , Gihan Ketawala , Jose M Martin-Garcia , Megan L Shelby , Thomas D Grant , Valerio Mariani , Alexandra Tolstikova , Michelle Z Sheikh , Mimi Cho Yung , Matthew A Coleman , Sahba Zaare , Emily K Kaschner , Mohammad Towshif Rabbani , Reza Nazari , Michele A Zacks , Brandon Hayes , Raymond G Sierra , Mark S Hunter , Stella Lisova , Alexander Batyuk , Christopher Kupitz , Sebastien Boutet , Debra T Hansen , Richard A Kirian , Marius Schmidt , Raimund Fromme , Matthias Frank , Alexandra Ros , Julian J-L Chen , Sabine Botha , Petra Fromme

Journal: Structure.

PubMed ID: 36630960

Doi: 10.1016/j.str.2022.12.009

Products & Services: Proteins, Expression, Isolation and Analysis

Heteromultivalent scaffolds fabricated by biomimetic co-assembly of DNA-RNA building blocks for the multi-analysis of miRNAs

Authors: Chengjie Duan, Yan Chen, Zhiqiang Hou, Dayong Li, Jin Jiao, Weihao Sun, Yang Xiang

Journal: J Mater Chem B

PubMed ID: 36723144

Doi: 10.1039/d2tb02663e

Products & Services: Proteins, Expression, Isolation and Analysis

Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes

Authors: Yi Sun, Georgia F Papadaki, Christine A Devlin, Julia N Danon, Michael C Young, Trenton J Winters, George M Burslem, Erik Procko, Nikolaos G Sgourakis

Journal: Sci Adv

PubMed ID: 36827371

Doi: 10.1126/sciadv.ade7151

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Functional analysis of 110 phosphorylation sites on the circadian clock protein FRQ identifies clusters determining period length and temperature compensation

Authors: Bin Wang, Elizabeth-Lauren Stevenson, Jay C Dunlap

Journal: G3 (Bethesda)

PubMed ID: 36537198

Doi: 10.1093/g3journal/jkac334

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Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols

Authors: Calvin Dumesnil, Lauri Vanharanta, Xavier Prasanna, Mohyeddine Omrane, Maxime Carpentier, Apoorva Bhapkar, Giray Enkavi, Veijo T Salo, Ilpo Vattulainen, Elina Ikonen, Abdou Rachid Thiam

Journal: Nat Commun

PubMed ID: 36807572

Doi: 10.1038/s41467-023-36375-6

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Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease

Authors: Rui Zhao, Li Cao, Wen-Jun Gu, Lei Li, Zhong-Zhong Chen, Jie Xiang, Ze-Yu Zhou, Bo Xu, Wei-Dong Zang, Xiang-Yu Zhou, Jing Cao, Kun Sun, Jian-Yuan Zhao

Journal: Cell Rep Med

PubMed ID: 36809766

Doi: 10.1016/j.xcrm.2023.100953

Products & Services: Proteins, Expression, Isolation and Analysis

A midposition NOTCH3 truncation in inherited cerebral small vessel disease may affect the protein interactome

Authors: Soo Jung Lee , Xiaojie Zhang , Gang Xu , Jimo Borjigin , Michael M Wang

Journal: J Biol Chem .

PubMed ID: 36470429

Doi: 10.1016/j.jbc.2022.102772

Products & Services: Peptide Synthesis Proteins, Expression, Isolation and Analysis

Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants

Authors: Saskia Meyer , Isaac Blaas , Ravi Chand Bollineni , Marina Delic-Sarac , Trung T Tran , Cathrine Knetter , Ke-Zheng Dai , Torfinn Støve Madssen , John T Vaage , Alice Gustavsen , Weiwen Yang , Lise Sofie Haug Nissen-Meyer , Karolos Douvlataniotis , Maarja Laos , Morten Milek Nielsen , Bernd Thiede , Arne Søraas , Fridtjof Lund-Johansen , Even H Rustad, Johanna Olweus

Journal: Cell Rep .

PubMed ID: 36656713

Doi: 10.1016/j.celrep.2023.111995

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Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor

Authors: Jia Duan , Peiyu Xu , Huibing Zhang , Xiaodong Luan , Jiaqi Yang, Xinheng He , Chunyou Mao , Dan-Dan Shen , Yujie Ji , Xi Cheng , Hualiang Jiang , Yi Jiang , Shuyang Zhang , Yan Zhang , H Eric Xu

Journal: Nat Commun .

PubMed ID: 36720854

Doi: 10.1038/s41467-023-36170-3

Products & Services: Proteins, Expression, Isolation and Analysis

Wheat yellow mosaic virus NIb targets TaVTC2 to elicit broad-spectrum pathogen resistance in wheat.

Authors: Zhang Tianye, Hu Haichao, Wang Ziqiong, Feng Tianyou, Yu Lu, Jie Zhang, Gao Wenqing, Zhou Yilin, Meihao Sun, Peng Liu, Zhong Kaili, Chen ZhiHui, Jianping Chen, Wei Li, Jian Yang

Journal: Plant Biotechnology Journal

PubMed ID: 36715229

Doi: 10.1111/pbi.14019

Products & Services: Proteins, Expression, Isolation and Analysis

Simultaneous capture of ISG15 conjugating and deconjugating enzymes using a semi-synthetic ISG15-Dha probe

Authors: Chuntong Li, Tian Wang, Lujun Liang, Guochao Chu, Jiachen Zhang, Wei He, Lei Liu, Jinghong Li

Journal: Science China. Chemistry

PubMed ID: 36684644

Doi: 10.1007/s11426-022-1455-x

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lectrochemical and Structural Study of the Buried Tryptophan in Azurin: Effects of Hydration and Polarity on the Redox Potential of W48

Authors: Kristin Tyson, Chanin B Tangtartharakul, Matthias Zeug, Nathan Findling, Alice Haddy, Eli Hvastkovs, Jun-Yong Choe, Judy E Kim, Adam R Offenbacher

Journal: The Journal of Physical Chemistry. B

PubMed ID: 36542812

Doi: 10.1021/acs.jpcb.2c06677

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Cryo-EM structures of orphan GPR21 signaling complexes

Authors: Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng, Suwen Zhao, Fei Xu

Journal: nature communications

PubMed ID: 36639690

Doi: 10.1038/s41467-023-35882-w

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Subunit Vaccine Targeting Phosphate ABC Transporter ATP-Binding Protein, PstB, Provides Cross-Protection against Serotype 2, 7, and 9 in Mice

Authors: Zujie Yan, Xiaohui Yao, Ruyi Pan, Junjie Zhang, Xiaochun Ma, Nihua Dong, Jianchao Wei, Ke Liu, Yafeng Qiu, Katie Sealey, Hester Nichols, Michael A Jarvis, Mathew Upton, Xiangdong Li, Zhiyong Ma, Juxiang Liu, Beibei Li

Journal: Vet Sci

PubMed ID: 36669049

Doi: 10.3390/vetsci10010048

Products & Services: Proteins, Expression, Isolation and Analysis

A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells

Authors: Kakeru Sato, Tatsuya Seki, Asuka Mizutani, Yuka Muranaka, Shiho Hirota, Kodai Nishi, Kana Yamazaki, Ryuichi Nishii, Takeo Nakanishi, Ikumi Tamai, Keiichi Kawai, Masato Kobayashi

Journal: Front Pharmacol

PubMed ID: 36712667

Doi: 10.3389/fphar.2022.1069321

Products & Services: Proteins, Expression, Isolation and Analysis

Transcriptomic exploration of the Coleopteran wings reveals insight into the evolution of novel structures associated with the beetle elytron

Authors: David M Linz, Yuichiro Hara, Kevin D Deem, Shigehiro Kuraku, Shigeo Hayashi, Yoshinori Tomoyasu

Journal: J Exp Zool B Mol Dev Evol

PubMed ID: 36617687

Doi: 10.1002/jez.b.23188

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Calmodulin variants associated with congenital arrhythmia impair selectivity for ryanodine receptors

Authors: Giuditta Dal Cortivo, Valerio Marino, Silvia Bianconi, Daniele Dell'Orco

Journal: Front Mol Biosci

PubMed ID: 36685279

Doi: 10.3389/fmolb.2022.1100992

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Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation

Authors: Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Michael Bowman, Lih-Ling Lin, Hao Wu, James Jeiwen Chou

Journal: Cell Res

PubMed ID: 36604598

Doi: 10.1038/s41422-022-00755-2

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Vaccination with S, an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice

Authors: Yongliang Zhao, Wenjia Ni, Simeng Liang, Lianghui Dong, Min Xiang, Zeng Cai, Danping Niu, Qiuhan Zhang, Dehe Wang, Yucheng Zheng, Zhen Zhang, Dan Zhou, Wenhua Guo, Yongbing Pan, Xiaoli Wu, Yimin Yang, Zhaofei Jing, Yongzhong Jiang, Yu Chen, Huan Yan, Yu Zhou, Ke Xu, Ke Lan

Journal: Sci Transl Med

PubMed ID: 36599007

Doi: 10.1126/scitranslmed.abo3332

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Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress

Authors: Samuel C Woodburn, Helina S Asrat, James K Flurer, Hana C Schwierling, Justin L Bollinger, Lauren L Vollmer, Eric S Wohleb

Journal: Brain Behav Immun

PubMed ID: 36681359

Doi: 10.1016/j.bbi.2023.01.014

Products & Services: Proteins, Expression, Isolation and Analysis

Chronic intermittent hypoxia-induced BNIP3 expression mitigates contractile dysfunction and myocardial injury in animal and cell model via modulating autophagy

Authors: Ruifang Chi, Chanjuan Chai, Gaizhen Liu, Huili Cao, Bin Yang

Journal: Hum Cell

PubMed ID: 36627546

Doi: 10.1007/s13577-022-00851-w

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Exploring the Expression and Function of cTyro3, a Candidate Zika Virus Receptor, in the Embryonic Chicken Brain and Inner Ear

Authors: Vashi Negi, Richard J Kuhn, Donna M Fekete

Journal: Viruses

PubMed ID: 36680287

Doi: 10.3390/v15010247

Products & Services: Proteins, Expression, Isolation and Analysis

Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding Antibodies

Authors: Kenya Moore, Urmi Sengupta, Nicha Puangmalai, Nemil Bhatt, Rakez Kayed

Journal: Mol Neurobiol

PubMed ID: 36707462

Doi: 10.1007/s12035-023-03211-3

Products & Services: Proteins, Expression, Isolation and Analysis

A non-toxic recombinant bivalent chimeric protein rETXCSA as a potential vaccine candidate against enterotoxemia and braxy

Authors: Jige Du, Bo Liu, Tuanjie Wang, Zhen Zhu, Chunsheng Yin, Yufeng Luo, Ying Liu, Xiaoyun Chen

Journal: Vaccine

PubMed ID: 36635138

Doi: 10.1016/j.vaccine.2022.11.021

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Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees

Authors: Pei Yu, Zijian Liu, Zhuoqi Zhu, Jiaqing Yang, Min Deng, Mingxiao Chen, Changchun Lai, Weiya Kong, Shilong Xiong, Li Wan, Weikang Mai, Lu Chen, Yu Lei, Shahzad Akbar Khan, Jianfeng Ruan, An Kang, Xuguang Guo, Qiang Zhou, Wenrui Li, Zheng Chen, Yuemei Liang, Pingchao Li, Lei Zhang, Tianxing Ji

Journal: Virol Sin

PubMed ID: 36603767

Doi: 10.1016/j.virs.2022.12.008

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Nanocell COVID-19 vaccine triggers a novel immune response pathway producing high-affinity antibodies which neutralize all variants of concern

Authors: Steven Y Gao, Nancy B Amaro-Mugridge, Jocelyn Madrid-Weiss, Nikolina Petkovic, Natasha Vanegas, Kumar Visvanathan, Bryan R G Williams, Jennifer A MacDiarmid, Himanshu Brahmbhatt

Journal: Front Immunol

PubMed ID: 36818474

Doi: 10.3389/fimmu.2022.1038562

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Detection and Molecular Characterization of the SARS-CoV-2 Delta Variant and the Specific Immune Response in Companion Animals in Switzerland

Authors: Evelyn Kuhlmeier, Tatjana Chan, Cecilia Valenzuela Agüí, Barbara Willi, Aline Wolfensberger, Christian Beisel, Ivan Topolsky, Niko Beerenwinkel, Tanja Stadler, Sarah Jones, Grace Tyson, Margaret J Hosie, Katja Reitt, Julia Hüttl, Marina L Meli, Regina Hofmann-Lehmann

Journal: Viruses

PubMed ID: 36680285

Doi: 10.3390/v15010245

Products & Services: Proteins, Expression, Isolation and Analysis

Defending against SARS-CoV-2: The T cell perspective

Authors: Patricia Almendro-Vázquez, Rocío Laguna-Goya, Estela Paz-Artal

Journal: Front Immunol

PubMed ID: 36776863

Doi: 10.3389/fimmu.2023.1107803

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Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance

Authors: Dario Gerace, Quan Zhou, Jennifer Hyoje-Ryu Kenty, Adrian Veres, Elad Sintov, Xi Wang, Kyle R Boulanger, Hongfei Li, Douglas A Melton

Journal: Cell Rep Med

PubMed ID: 36599351

Doi: 10.1016/j.xcrm.2022.100879

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Low-cost and prototype-friendly method for biocompatible encapsulation of implantable electronics with epoxy overmolding, hermetic feedthroughs and P3HT coating

Authors: Marek Novák, Jozef Rosina, Hana Bendová, Kristina Kejlová, Alena Vlková, Marian Rucki, Lada Svobodová, Robert Gürlich, Jan Hajer

Journal: Sci Rep

PubMed ID: 36717683

Doi: 10.1038/s41598-023-28699-6

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Dependency of sanitation infrastructure on the discharge of faecal coliform and SARS-CoV-2 viral RNA in wastewater from COVID and non-COVID hospitals in Dhaka, Bangladesh

Authors: Nuhu Amin, Rehnuma Haque, Md Ziaur Rahman, Mohammed Ziaur Rahman, Zahid Hayat Mahmud, Rezaul Hasan, Md Tahmidul Islam, Protim Sarker, Supriya Sarker, Shaikh Daud Adnan, Nargis Akter, Dara Johnston, Mahbubur Rahman, Pengbo Liu, Yuke Wang, Tahmina Shirin, Mahbubur Rahman, Prosun Bhattacharya

Journal: Sci Total Environ

PubMed ID: 36623655

Doi: 10.1016/j.scitotenv.2023.161424

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Exploiting natural riboswitches for aptamer engineering and validation

Authors: Michael G Mohsen, Matthew K Midy, Aparaajita Balaji, Ronald R Breaker

Journal: Nucleic Acids Res

PubMed ID: 36617976

Doi: 10.1093/nar/gkac1218

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Monosynaptic restriction of the anterograde herpes simplex virus strain H129 for neural circuit tracing

Authors: Kyle B Fischer, Hannah K Collins, Yan Pang, Dheeraj S Roy, Ying Zhang, Guoping Feng, Shu-Jing Li, Adam Kepecs, Edward M Callaway

Journal: J Comp Neurol

PubMed ID: 36606699

Doi: 10.1002/cne.25451

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Evaluation of a biotin-based surrogate virus neutralization test for detecting postvaccination antibodies against SARS-CoV-2 variants in sera

Authors: Min-Ju Ahn, Jung-Ah Kang, Su Min Hong, Kyu-Sun Lee, Dong Ho Kim, Daesub Song, Dae Gwin Jeong

Journal: Biochem Biophys Res Commun

PubMed ID: 36696754

Doi: 10.1016/j.bbrc.2023.01.052

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PLK1 and AURKB phosphorylate survivin differentially to affect proliferation in racially distinct triple-negative breast cancer

Authors: Chakravarthy Garlapati, Shriya Joshi, Shristi Bhattarai, Jayashree Krishnamurthy, Ravi Chakra Turaga, Thi Nguyen, Xiaoxian Li, Ritu Aneja

Journal: Cell Death Dis

PubMed ID: 36627281

Doi: 10.1038/s41419-022-05539-5

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Pold4 is dispensable for mouse development, DNA replication and DNA repair

Authors: Xueping Gu , Qinjin Dai , Peng Du , Ning Li , Jiahui Li , Simiao Zeng , Shuyi Peng , Shengjun Tang , Lei Wang , Zhongcheng Zhou

Journal: Gene

PubMed ID: 36356905

Doi: 10.1016/j.gene.2022.147029

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Expression and kinetic characterization of PYCR3 Kaylen

Authors: Kaylen R Meeks , John J Tanner

Journal: Arch Biochem Biophys

PubMed ID: 36414121

Doi: 10.1016/j.abb.2022.109468

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Radiotherapy-Triggered Proteolysis Targeting Chimera Prodrug Activation in Tumors

Authors: Chunrong Yang , Yuchen Yang , Yujie Li , Qiankun Ni , Jinghong Li

Journal: J Am Chem Soc.

PubMed ID: 36542856

Doi: 10.1021/jacs.2c10177

Products & Services: Proteins, Expression, Isolation and Analysis

RsCLE22a regulates taproot growth through an auxin signaling-related pathway in radish (Raphanus sativus L)

Authors: Junhui Dong, Yan Wang, Liang Xu, Bingshuang Li, Kai Wang, Jiali Ying, Qing He, Liwang Liu

Journal: J Exp Bot

PubMed ID: 36239471

Doi: 10.1093/jxb/erac406

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Atlantic cod () MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals

Authors: Synne Arstad Bjørnestad, Monica Hongrø Solbakken, Kjetill S Jakobsen, Sissel Jentoft, Oddmund Bakke, Cinzia Progida

Journal: Front Cell Dev Biol

PubMed ID: 36760361

Doi: 10.3389/fcell.2023.1050323

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Linoleic acid ameliorates intestinal mucosal barrier injury in early weaned pigeon squabs (Columba livia)

Authors: Qianqian Xu, Jin Zhao, Huafeng Jian, Jiangcheng Ye, Mingxiu Gong, Xiaoting Zou, Xinyang Dong

Journal: J Anim Sci

PubMed ID: 37186172

Doi: 10.1093/jas/skad125

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Mesenchymal stem cell-derived extracellular vesicles transfer miR-598 to inhibit the growth and metastasis of non-small-cell lung cancer by targeting THBS2

Authors: Xuebo Li, Fan Wu

Journal: Cell Death Discov

PubMed ID: 36609437

Doi: 10.1038/s41420-022-01283-z

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Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates

Authors: Daehun Park, Yumei Wu, Xinbo Wang, Swetha Gowrishankar, Aaron Baublis, Pietro De Camilli

Journal: Nat Commun

PubMed ID: 36709207

Doi: 10.1038/s41467-023-36081-3

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CRISPR mediated transactivation in the human disease vector Aedes aegypti

Authors: Michelle Bui, Elena Dalla Benetta, Yuemei Dong, Yunchong Zhao, Ting Yang, Ming Li, Igor A Antoshechkin, Anna Buchman, Vanessa Bottino-Rojas, Anthony A James, Michael W Perry, George Dimopoulos, Omar S Akbari

Journal: PLoS Pathog

PubMed ID: 36656895

Doi: 10.1371/journal.ppat.1010842

Products & Services: Proteins, Expression, Isolation and Analysis

A method for mapping the linear epitopes targeted by the natural antibody response to Zika virus infection using a VLP platform technology

Authors: Alexandra Fowler, Chunyan Ye, Elizabeth C Clarke, Juan M Pascale, David S Peabody, Steven B Bradfute, Kathryn M Frietze, Bryce Chackerian

Journal: Virology

PubMed ID: 36623351

Doi: 10.1016/j.virol.2023.01.001

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SARS-CoV-2-free residual proteins mediated phenotypic and metabolic changes in peripheral blood monocytic-derived macrophages in support of viral pathogenesis

Authors: Mohammad G Mohammad, Naglaa S Ashmawy, Ahmed M Al-Rawi, Ameera Abu-Qiyas, Alshaimaa M Hamoda, Rania Hamdy, Salam Dakalbab, Shahad Arikat, Dana Salahat, Mohamed Madkour, Sameh S M Soliman

Journal: PLoS ONE

PubMed ID: 36656874

Doi: 10.1371/journal.pone.0280592

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RACK1 release from the Ribosome Couples Translational Regulation with Starving Signaling and Possibly Depends on Phosphorylation of Key Serine and Threonine Residues

Authors: Maria Kiratzis, Giancarlo Lai, Piera Calamita, Marilena Mancino, Marcello Iriti, Nicola Manfrini, Simone Gallo

Journal: Cell Mol Biol (Noisy-le-grand)

PubMed ID: 37213164

Doi: 10.14715/cmb/2022.69.1.2

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Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal

Authors: Mikayla Hoad, Emily M Cross, Camilla M Donnelly, Subir Sarker, Justin A Roby, Jade K Forwood

Journal: Viruses

PubMed ID: 36851528

Doi: 10.3390/v15020315

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Maltose-Enhanced Exopolysaccharide Synthesis of through CRP-like Protein

Authors: Fanqiang Meng, Yunbin Lyu, Xiaoyu Chen, Fengxia Lu, Haizhen Zhao, Yingjian Lu, Mingwen Zhao, Zhaoxin Lu

Journal: J Agric Food Chem

PubMed ID: 36602107

Doi: 10.1021/acs.jafc.2c07880

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Loss-of-function KCa2.2 mutations abolish channel activity

Authors: Young-Woo Nam , Mohammad Asikur Rahman , Grace Yang , Razan Orfali , Meng Cui , Miao Zhang

Journal: Am J Physiol Cell Physiol

PubMed ID: 36717104

Doi: 10.1152/ajpcell.00584.2022

Products & Services: PCR Cloning and Subcloning

Activity, Template Preference, and Compatibility of Components of RNA Replicase of Eastern Equine Encephalitis Virus

Authors: Laura Sandra Lello, Agneta Miilimäe, Liubov Cherkashchenko, Ailar Omler, Rachel Skilton, Rachel Ireland, David Ulaeto, Andres Merits

Journal: J Virol

PubMed ID: 36533950

Doi: 10.1128/jvi.01368-22

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Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

Authors: Sangwook Oh, Xuming Mao, Silvio Manfredo-Vieira, Jinmin Lee, Darshil Patel, Eun Jung Choi, Andrea Alvarado, Ebony Cottman-Thomas, Damian Maseda, Patricia Y Tsao, Christoph T Ellebrecht, Sami L Khella, David P Richman, Kevin C O'Connor, Uri Herzberg, Gwendolyn K Binder, Michael C Milone, Samik Basu, Aimee S Payne

Journal: Nat Biotechnol

PubMed ID: 36658341

Doi: 10.1038/s41587-022-01637-z

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Circ-N4BP2L2 enhances mitochondrial function in non-small cell lung cancer cells through regulating the miR-135a-5p/ARL5B axis

Authors: Hongyang Shi, Yuqiang Ji, Yonghong Zhang, Yu Wang, Wei Li

Journal: Environ Toxicol

PubMed ID: 36637163

Doi: 10.1002/tox.23736

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Characterizing asparagine synthetase deficiency variants in lymphoblastoid cell lines

Authors: Stephen J Staklinski, Mario C Chang, Rebecca C Ahrens-Nicklas, Shagun Kaur, Arianna K Stefanatos, Elizabeth E Dudenhausen, Matthew E Merritt, Michael S Kilberg

Journal: JIMD Rep

PubMed ID: 36873094

Doi: 10.1002/jmd2.12356

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Magnaporthe oryzae pathotype Triticum (MoT) can act as a heterologous expression system for fungal effectors with high transcript abundance in wheat

Authors: Cassandra Jensen, Diane G O Saunders

Journal: Sci Rep

PubMed ID: 36596834

Doi: 10.1038/s41598-022-27030-z

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Genetic code expansion reveals aminoacylated lysine ubiquitination mediated by UBE2W

Authors: Jia Zang, Yulin Chen, Chao Liu, Linzhen Hu, Hongxia Zhao, Wenlong Ding, Ying Yuan, Shixian Lin

Journal: Nat Struct Mol Biol

PubMed ID: 36593310

Doi: 10.1038/s41594-022-00866-9

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Label-free impedimetric immunosensor for point-of-care detection of COVID-19 antibodies

Authors: Lian C T Shoute, Gaser N Abdelrasoul, Yuhao Ma, Pedro A Duarte, Cole Edwards, Ran Zhuo, Jie Zeng, Yiwei Feng, Carmen L Charlton, Jamil N Kanji, Shawn Babiuk, Jie Chen

Journal: Microsyst Nanoeng

PubMed ID: 36597510

Doi: 10.1038/s41378-022-00460-5

Products & Services: PCR Cloning and Subcloning

Indolethylamine N-methyltransferase (INMT) is not essential for endogenous tryptamine-dependent methylation activity in rats

Authors: NicolasG.Glynos, Lily Carter, Soo Jung Lee, Youngsoo Kim , RobertT. Kennedy, GeorgeA. Mashour, Michael M. Wang & Jimo Borjigin

Journal: Scientific Reports

PubMed ID: 36609666

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The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae

Authors: Giovanni Covaleda-Cortés, Ariel Mechaly, Terry Brissac, Heike Baehre, Laura Devaux, Patrick England, Bertrand Raynal, Sylviane Hoos, Myriam Gominet, Arnaud Firon, Patrick Trieu-Cuot, Pierre Alexandre Kaminski

Journal: FEBS J

PubMed ID: 36629470

Doi: 10.1111/febs.16724

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Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q133 microdeletion syndrome

Authors: Brianna K Unda, Leon Chalil, Sehyoun Yoon, Savannah Kilpatrick, Courtney Irwin, Sansi Xing, Nadeem Murtaza, Anran Cheng, Chad Brown, Alexandria Afonso, Elizabeth McCready, Gabriel M Ronen, Jennifer Howe, Aurélie Caye-Eude, Alain Verloes, Brad W Doble, Laurence Faivre, Antonio Vitobello, Stephen W Scherer, Yu Lu, Peter Penzes, Karun K Singh

Journal: Mol Psychiatry

PubMed ID: 36604605

Doi: 10.1038/s41380-022-01937-5

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Long-term blue light exposure impairs mitochondrial dynamics in the retina in light-induced retinal degeneration in vivo and in vitro

Authors: Liyin Wang, Xin Yu, Dongyan Zhang, Yingying Wen, Liyue Zhang, Yutong Xia, Jinbo Chen, Chen Xie, Hong Zhu, Jianping Tong, Ye Shen

Journal: J Photochem Photobiol B

PubMed ID: 36724628

Doi: 10.1016/j.jphotobiol.2023.112654

Products & Services: Proteins, Expression, Isolation and Analysis

Functional Impact of a Cancer-Related Variant in Human Δ1-Pyrroline-5-Carboxylate Reductase 1

Authors: Oseeyi I Daudu , Kaylen R Meeks , Lu Zhang , Javier Seravalli , John J Tanner , Donald F Becker

Journal: ACS Omega .

PubMed ID: 36713721

Doi: 10.1021/acsomega.2c07788

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The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer

Authors: Xue Yang, Miguel I Cruz, Elizabeth V Nguyen, Cheng Huang, Ralf B Schittenhelm, Jennii Luu, Karla J Cowley, Sung-Young Shin, Lan K Nguyen, Terry C C Lim Kam Sian, Kimberley C Clark, Kaylene J Simpson, Xiuquan Ma, Roger J Daly

Journal: Oncogene

PubMed ID: 36693952

Doi: 10.1038/s41388-023-02594-w

Products & Services: Proteins, Expression, Isolation and Analysis

Impacts of delta and omicron variants on inactivated SARS-CoV-2 vaccine-induced T cell responses in patients with autoimmune diseases and healthy controls

Authors: Shuyi Wang, Jin Li, Shuang Wang, Yujin Ye, Mengyuan Li, Yihao Liu, Binfeng Chen, Yimei Lai, Liubing Li, Lili Zhuang, Sui Peng, Niansheng Yang, Hui Zhang, Haipeng Xiao

Journal: Clin Transl Med

PubMed ID: 36639826

Doi: 10.1002/ctm2.1171

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