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Single-Molecule Interconversion between Chiral Configurations of Boronate Esters Observed in a Nanoreactor

Authors: Xiaoyu Du, Shanyu Zhang, Liying Wang, Yuqin Wang, Pingping Fan, Wendong Jia, Panke Zhang, Shuo Huang

Journal: ACS Nano

PubMed ID: 36655995

Doi: 10.1021/acsnano.2c11286

Products & Services: Plasmid DNA Preparation

The activation mechanism and antibody binding mode for orphan GPR20

Authors: Xi Lin, Shan Jiang, Yiran Wu, Xiaohu Wei, Gye-Won Han, Lijie Wu, Junlin Liu, Bo Chen, Zhibin Zhang, Suwen Zhao, Vadim Cherezov, Fei Xu

Journal: Cell Discovery

PubMed ID: 36849514

Doi: 10.1038/s41421-023-00520-8

Products & Services: Gene Synthesis

Barrier properties of Nup98 FG phases ruled by FG motif identity and inter-FG spacer length

Authors: Sheung Chun Ng, Abin Biswas, Trevor Huyton, Jürgen Schünemann, Simone Reber, Dirk Görlich

Journal: Nat Commun

PubMed ID: 36765044

Doi: 10.1038/s41467-023-36331-4

Products & Services: Proteins, Expression, Isolation and Analysis

Safety and Immunogenicity of Betuvax-CoV-2, an RBD-Fc-Based SARS-CoV-2 Recombinant Vaccine: Preliminary Results of the First-in-Human, Randomized, Double-Blind, Placebo-Controlled Phase I/II Clinical Trial

Authors: Aleksandr V Kudriavtsev, Anna V Vakhrusheva, Nickolay A Kryuchkov, Maria E Frolova, Konstantin A Blagodatskikh, Taras V Ivanishin, Milana Djonovic, Ekaterina A Romanovskaya-Romanko, Anton N Kovalenko, Dmitry A Lioznov, Tatiana G Zubkova, Svetlana V Teplykh, Rodion A Oseshnyuk, Marina A Stukova, Artur A Isaev, Igor V Krasilnikov

Journal: Vaccines (Basel)

PubMed ID: 36851204

Doi: 10.3390/vaccines11020326

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of cross-reactive monoclonal antibodies against SARS-CoV-1 and SARS-CoV-2: Implication for rational design and development of pan-sarbecovirus vaccines and neutralizing antibodies

Authors: Shibo Li, Jianbo Wu, Weiyu Jiang, Haiyan He, Yunjiao Zhou, Wei Wu, Yidan Gao, Minxiang Xie, Anqi Xia, Jiaying He, Qianqian Zhang, Yuru Han, Nan Wang, Guangqi Zhu, Qiujing Wang, Zheen Zhang, Christian T Mayer, Kang Wang, Xiangxi Wang, Junqing Wang, Zhenguo Chen, Shibo Jiang, Lei Sun, Rong Xia, Qiao Wang

Journal: J Med Virol

PubMed ID: 36573441

Doi: 10.1002/jmv.28440

Products & Services: Molecular Biology Reagents

Acid-Responsive Immune-Enhancing Chitosan Formulation Capable of Transforming from Particle Stabilization to Polymer Chain Stabilization

Authors: Yongjuan Zou, Xiaoxuan Liu, Qiuting Chen, Hiroyuki Oku, Guanghui Ma, Jie Wu

Journal: ACS Appl Mater Interfaces

PubMed ID: 36825996

Doi: 10.1021/acsami.2c17505

Products & Services: Proteins, Expression, Isolation and Analysis

Connection between MHC class II binding and aggregation propensity: The antigenic peptide 10 of as a benchmark study

Authors: Rodrigo Ochoa, Thyago R Cardim-Pires, Ricardo Sant'Anna, Pilar Cossio, Debora Foguel

Journal: Comput Struct Biotechnol J

PubMed ID: 36890879

Doi: 10.1016/j.csbj.2023.02.031

Products & Services: Molecular Biology Reagents

Antibody isotype epitope mapping of SARS-CoV-2 Spike RBD protein: Targets for COVID-19 symptomatology and disease control

Authors: Marinela Contreras, Joaquín Vicente, José Joaquín Cerón, Silvia Martinez Subiela, José Miguel Urra, Francisco J Rodríguez-Del-Río, Elisa Ferreras-Colino, Rita Vaz-Rodrigues, Isabel G de Fernández de Mera, Sandra Antunes, Ana Domingos, Christian Gortázar, José de la Fuente

Journal: Eur J Immunol

PubMed ID: 36658749

Doi: 10.1002/eji.202250206

Products & Services: Molecular Biology Reagents

Smartphone-based chemiluminescence detection of aflatoxin B via labelled and label-free dual sensing systems

Authors: Junning Ma, Yue Guan, Fuguo Xing, Yan Wang, Xu Li, Qiang Yu, Xiaohua Yu

Journal: Food Chem

PubMed ID: 36796268

Doi: 10.1016/j.foodchem.2023.135654

Products & Services: Molecular Biology Reagents

Generation and characterization of an immunodeficient mouse model of mucopolysaccharidosis type II

Authors: Miles C Smith, Lalitha R Belur, Andrea D Karlen, Kelly Podetz-Pedersen, Olivia Erlanson, Kanut Laoharawee, Justin Furcich, Troy C Lund, Yun You, Davis Seelig, Beau R Webber, R Scott McIvor

Journal: Mol Genet Metab

PubMed ID: 37023503

Doi: 10.1016/j.ymgme.2023.107539

Products & Services: Gene Synthesis

The molecular mechanism of light-induced bond formation and breakage in the cyanobacteriochrome TePixJ

Authors: Jeannette Ruf, Flavia Bindschedler, David Buhrke

Journal: Phys Chem Chem Phys

PubMed ID: 36752541

Doi: 10.1039/d2cp05856a

Products & Services: Proteins, Expression, Isolation and Analysis

The molecular chaperone cysteine string protein is required for monomeric SNARE proteins to assemble in trans-complexes during human sperm acrosomal exocytosis†

Authors: Karina Flores-Montero, María Victoria Berberián, Luis Segundo Mayorga, Claudia Nora Tomes, María Celeste Ruete

Journal: Biol Reprod

PubMed ID: 36308432

Doi: 10.1093/biolre/ioac196

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of a TatA/TatB binding site on the TatC component of the twin arginine translocase

Authors: Emmanuele Severi, Mariana Bunoro Batista, Adelie Lannoy, Phillip J Stansfeld, Tracy Palmer

Journal: Microbiology (Reading)

PubMed ID: 36790402

Doi: 10.1099/mic.0.001298

Products & Services: Proteins, Expression, Isolation and Analysis

CriSNPr, a single interface for the curated and de novo design of gRNAs for CRISPR diagnostics using diverse Cas systems

Authors: Asgar H Ansari, Manoj Kumar, Sajal Sarkar, Souvik Maiti, Debojyoti Chakraborty

Journal: Elife

PubMed ID: 36752591

Doi: 10.7554/eLife.77976

Products & Services: Proteins, Expression, Isolation and Analysis

Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit

Authors: Jonah Elliff, Aparna Biswas, Poonam Roshan, Sahiti Kuppa, Angela Patterson, Jenna Mattice, Mathivanan Chinnaraj, Ryan Burd, Sarah E Walker, Nicola Pozzi, Edwin Antony, Brian Bothner, Sofia Origanti

Journal: Nucleic Acids Res

PubMed ID: 36651285

Doi: 10.1093/nar/gkac1266

Products & Services: Proteins, Expression, Isolation and Analysis

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

Authors: Romain Rouet, Jake Y Henry, Matt D Johansen, Meghna Sobti, Harikrishnan Balachandran, David B Langley, Gregory J Walker, Helen Lenthall, Jennifer Jackson, Stephanie Ubiparipovic, Ohan Mazigi, Peter Schofield, Deborah L Burnett, Simon H J Brown, Marianne Martinello, Bernard Hudson, Nicole Gilroy, Jeffrey J Post, Anthony Kelleher, Hans-Martin Jäck, Christopher C Goodnow, Stuart G Turville, William D Rawlinson, Rowena A Bull, Alastair G Stewart, Philip M Hansbro, Daniel Christ

Journal: Nat Commun

PubMed ID: 36755042

Doi: 10.1038/s41467-023-36295-5

Products & Services: Proteins, Expression, Isolation and Analysis

KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/β-Catenin Signaling Pathway

Authors: Ying Li, Yu Wang, Qinguang Zou, Shouqing Li, Fan Zhang

Journal: Lab Invest

PubMed ID: 36827869

Doi: 10.1016/j.labinv.2023.100078

Products & Services: Proteins, Expression, Isolation and Analysis

Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine

Authors: Thayne H Dickey, Richi Gupta, Holly McAleese, Tarik Ouahes, Sachy Orr-Gonzalez, Rui Ma, Olga Muratova, Nichole D Salinas, Jen C C Hume, Lynn E Lambert, Patrick E Duffy, Niraj H Tolia

Journal: npj Vaccines

PubMed ID: 36808125

Doi: 10.1038/s41541-023-00619-9

Products & Services: Proteins, Expression, Isolation and Analysis

Structure and dynamics of the EGFR/HER2 heterodimer

Authors: Xue Bai, Pengyu Sun, Xinghao Wang, Changkun Long, Shuyun Liao, Song Dang, Shangshang Zhuang, Yongtao Du, Xinyi Zhang, Nan Li, Kangmin He, Zhe Zhang

Journal: Cell Discov

PubMed ID: 36781849

Doi: 10.1038/s41421-023-00523-5

Products & Services: Proteins, Expression, Isolation and Analysis

Epitopes in the Glycosylphosphatidylinositol Attachment Signal Peptide of Trypanosoma cruzi Mucin Proteins Generate Robust but Delayed and Nonprotective CD8+ T Cell Responses

Authors: Molly E Bunkofske, Natasha Perumal, Brooke White, Eva-Maria Strauch, Rick Tarleton

Journal: J Immunol

PubMed ID: 36603035

Doi: 10.4049/jimmunol.2200723

Products & Services: Molecular Biology Reagents

Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A

Authors: Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Abankwa, Maja Köhn, Vesa P Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck

Journal: Nat Commun

PubMed ID: 36854761

Doi: 10.1038/s41467-023-36693-9

Products & Services: Molecular Biology Reagents

Big data mining, rational modification, and ancestral sequence reconstruction inferred multiple xylose isomerases for biorefinery

Authors: Sitong Chen, Zhaoxian Xu, Boning Ding, Yuwei Zhang, Shuangmei Liu, Chenggu Cai, Muzi Li, Bruce E Dale, Mingjie Jin

Journal: Sci Adv

PubMed ID: 36724227

Doi: 10.1126/sciadv.add8835

Products & Services: Molecular Biology Reagents

Network of hotspot interactions cluster tau amyloid folds

Authors: Vishruth Mullapudi, Jaime Vaquer-Alicea, Vaibhav Bommareddy, Anthony R Vega, Bryan D Ryder, Charles L White, Marc I Diamond, Lukasz A Joachimiak

Journal: Nat Commun

PubMed ID: 36797278

Doi: 10.1038/s41467-023-36572-3

Products & Services: Peptide Synthesis

Engineered biocontainable RNA virus vectors for non-transgenic genome editing across crop species and genotypes

Authors: Qian Liu, Chenglu Zhao, Kai Sun, Yinlu Deng, Zhenghe Li

Journal: Mol Plant

PubMed ID: 36751129

Doi: 10.1016/j.molp.2023.02.003

Products & Services: Peptide Synthesis

Efficient hydroxylation of flavonoids by using whole-cell P450 sca-2 biocatalyst in

Authors: Baodong Hu, Xinrui Zhao, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du

Journal: Front Bioeng Biotechnol

PubMed ID: 36873357

Doi: 10.3389/fbioe.2023.1138376

Products & Services: Gene Synthesis

Fused human paraoxonase 1 as a prophylactic agent against organophosphate poisoning

Authors: Prakashkumar Dobariya, Pratik Adhya, Bhupesh Vaidya, Prakash Y Khandave, Shyam Sunder Sharma, Abhay H Pande

Journal: Enzyme Microb Technol

PubMed ID: 36764031

Doi: 10.1016/j.enzmictec.2023.110209

Products & Services: Molecular Biology Reagents

Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions

Authors: Arun Kumar Somavarapu, Giulia Kleijwegt, Madhu Nagaraj, Parvez Alam, Janni Nielsen, Daniel E Otzen

Journal: Chem Sci

PubMed ID: 36937574

Doi: 10.1039/d2sc05534a

Products & Services: Recombinant Proteins

A rapid nucleic acid detection platform based on phosphorothioate-DNA and sulfur binding domain

Authors: Yuting Shuai, Yi Ju, Yuanhang Li, Dini Ma, Lan Jiang, Jingyu Zhang, Gao-Yi Tan, Xueting Liu, Shenlin Wang, Lixin Zhang, Guang Liu

Journal: Synth Syst Biotechnol

PubMed ID: 36875498

Doi: 10.1016/j.synbio.2023.02.002

Products & Services: Proteins, Expression, Isolation and Analysis

Cas12a-based one-pot SNP detection with high accuracy

Authors: Hong-Xia Zhang, Caixiang Zhang, Shuhan Lu, Xiaohan Tong, Kun Zhang, Hao Yin, Ying Zhang

Journal: Cell Insight

PubMed ID: 37193068

Doi: 10.1016/j.cellin.2023.100080

Products & Services: Proteins, Expression, Isolation and Analysis

Two pan-SARS-CoV-2 nanobodies and their multivalent derivatives effectively prevent Omicron infections in mice

Authors: Honghui Liu, Lili Wu, Bo Liu, Ke Xu, Wenwen Lei, Jianguo Deng, Xiaoyu Rong, Pei Du, Lebing Wang, Dongbin Wang, Xiaolong Zhang, Chao Su, Yuhai Bi, Hua Chen, William J Liu, Jianxun Qi, Qingwei Cui, Shuhui Qi, Ruiwen Fan, Jingkun Jiang, Guizhen Wu, George F Gao, Qihui Wang

Journal: cell reports. medicine

PubMed ID: 36702124

Doi: 10.1016/j.xcrm

Products & Services: Gene Synthesis

Siglec-9 Restrains Antibody-Dependent Natural Killer Cell Cytotoxicity against SARS-CoV-2

Authors: Pratima Saini, Opeyemi S Adeniji, Devivasha Bordoloi, Jennifer Kinslow, Jeff Martinson, Danielle M Parent, Kai Ying Hong, Jane Koshy, Abhijeet J Kulkarni, Netanel F Zilberstein, Robert A Balk, James N Moy, Leila B Giron, Russell P Tracy, Ali Keshavarzian, Kar Muthumani, Alan Landay, David B Weiner, Mohamed Abdel-Mohsen

Journal: MBio

PubMed ID: 36728420

Doi: 10.1128/mbio.03393-22

Products & Services: Proteins, Expression, Isolation and Analysis

Cathepsin H and cathepsin B of Cynoglossus semilaevis are involved in anti-bacterial immunity against Edwardsiella tarda

Authors: Yilong Wang, Hang Xu, Boguang Sun

Journal: Fish Shellfish Immunol

PubMed ID: 36754156

Doi: 10.1016/j.fsi.2023.108594

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular basis of RADAR anti-phage supramolecular assemblies

Authors: Yina Gao, Xiu Luo, Peipei Li, Zhaolong Li, Feng Ye, Songqing Liu, Pu Gao

Journal: Cell

PubMed ID: 36764292

Doi: 10.1016/j.cell.2023.01.026

Products & Services: Proteins, Expression, Isolation and Analysis

Insights into the oligomeric structure of the HIV-1 Vpu protein

Authors: Saman Majeed, Oluwatosin Adetuyi, Peter P Borbat, Md Majharul Islam, Olamide Ishola, Bo Zhao, Elka R Georgieva

Journal: J Struct Biol

PubMed ID: 36796461

Doi: 10.1016/j.jsb.2023.107943

Products & Services: Molecular Biology Reagents

Engineered antibody cytokine chimera synergizes with DNA-launched nanoparticle vaccines to potentiate melanoma suppression

Authors: Nicholas J Tursi, Ziyang Xu, Michaela Helble, Susanne Walker, Kevin Liaw, Neethu Chokkalingam, Toshitha Kannan, Yuanhan Wu, Edgar Tello-Ruiz, Daniel H Park, Xizhou Zhu, Megan C Wise, Trevor R F Smith, Sonali Majumdar, Andrew Kossenkov, Daniel W Kulp, David B Weiner

Journal: Front Immunol

PubMed ID: 36911698

Doi: 10.3389/fimmu.2023.1072810

Products & Services: Molecular Biology Reagents

Transcriptional dynamics of maize leaves, pollens and ovules to gain insights into heat stress-related responses

Authors: Ashok Babadev Jagtap, Inderjit Singh Yadav, Yogesh Vikal, Umesh Preethi Praba, Navneet Kaur, Adeshpal Singh Gill, Gurmukh S Johal

Journal: Front Plant Sci

PubMed ID: 36875566

Doi: 10.3389/fpls.2023.1117136

Products & Services: PCR Cloning and Subcloning

A Balance between Pro-Inflammatory and Pro-Reparative Macrophages is Observed in Regenerative D-MAPS

Authors: Yining Liu, Alejandra Suarez-Arnedo, Shamitha Shetty, Yaoying Wu, Michelle Schneider, Joel H Collier, Tatiana Segura

Journal: Adv Sci (Weinh)

PubMed ID: 36762570

Doi: 10.1002/advs.202204882

Products & Services: Peptide Synthesis

A novel role for trithorax in the gene regulatory network for a rapidly evolving fruit fly pigmentation trait

Authors: Michael L Weinstein, Chad M Jaenke, Hasiba Asma, Matthew Spangler, Katherine A Kohnen, Claire C Konys, Melissa E Williams, Ashley V Williams, Mark Rebeiz, Marc S Halfon, Thomas M Williams

Journal: PLoS Genet

PubMed ID: 36795790

Doi: 10.1371/journal.pgen.1010653

Products & Services: DNA Sequencing

Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu

Authors: Zeqian Xu, Xuanyu Qi, Minyue Bao, Tian Zhou, Junfeng Shi, Zhiyan Xu, Mingliang Zhou, Aldo R Boccaccini, Kai Zheng, Xinquan Jiang

Journal: Bioact Mater

PubMed ID: 36817824

Doi: 10.1016/j.bioactmat.2023.01.024

Products & Services: Custom RNAi Services

Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T-cell lymphotrophic virus-1 (HTLV-1) Tax1 PBM

Authors: Airah Javorsky, Janesha C Maddumage, Emily R R Mackie, Tatiana P Soares da Costa, Patrick O Humbert, Marc Kvansakul

Journal: The FEBS journal

PubMed ID: 36029163

Doi: 10.1111/febs.16607

Products & Services: Peptide Synthesis

Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination

Authors: Huasong Ai, Zebin Tong, Zhiheng Deng, Jiakun Tian, Liying Zhang, Maoshen Sun, Yunxiang Du, Ziyu Xu, Qiang Shi, Lujun Liang, Qingyun Zheng, Jia-Bin Li, Man Pan, and Lei Liu

Journal: Chem

Doi: 10.1016/j.chempr.2023.01.012

Products & Services: Gene Synthesis

Site-specific labeling of SBDS to monitor interactions with the 60S ribosomal subunit

Authors: Aparna Biswas, Yu-Fong Peng, Vikas Kaushik, Sofia Origanti

Journal: Methods

PubMed ID: 36781034

Doi: 10.1016/j.ymeth.2023.02.004

Products & Services: Proteins, Expression, Isolation and Analysis

The endogenous repertoire harbors self-reactive CD4 T cell clones that adopt a follicular helper T cell-like phenotype at steady state

Authors: Victoria Lee, Donald M Rodriguez, Nicole K Ganci, Sharon Zeng, Junting Ai, Jaime L Chao, Matthew T Walker, Christine H Miller, David E J Klawon, Mary H Schoenbach, Domenick E Kennedy, Mark Maienschein-Cline, Nicholas D Socci, Marcus R Clark, Peter A Savage

Journal: Nat Immunol

PubMed ID: 36759711

Doi: 10.1038/s41590-023-01425-0

Products & Services: Molecular Biology Reagents

Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria

Authors: Aidan J Preston, Aaron Rogers, Miranda Sharp, Gareth Mitchell, Cristhian Toruno, Brayden B Barney, Lauren N Donovan, Journey Bly, Ryan Kennington, Emily Payne, Anthony Iovino, Gabriela Furukawa, Rosann Robinson, Bahar Shamloo, Matthew Buccilli, Rachel Anders, Sarah Eckstein, Elizabeth A Fedak, Tanner Wright, Carlo C Maley, Wendy K Kiso, Dennis Schmitt, David Malkin, Joshua D Schiffman, Lisa M Abegglen

Journal: Cell Death Discov

PubMed ID: 36797268

Doi: 10.1038/s41420-023-01348-7

Products & Services: Molecular Biology Reagents

Soluble adenylyl cyclase coordinates intracellular pH homeostasis and biomineralization in calcifying cells of a marine animal

Authors: William Weijen Chang, Angus B Thies, Martin Tresguerres, Marian Y Hu

Journal: Am J Physiol Cell Physiol

PubMed ID: 36779665

Doi: 10.1152/ajpcell.00524.2022

Products & Services: Peptide Synthesis

Structure of metallochaperone in complex with the cobalamin-binding domain of its target mutase provides insight into cofactor delivery

Authors: Francesca A Vaccaro, David A Born, Catherine L Drennan

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36787360

Doi: 10.1073/pnas.2214085120

Products & Services: Insect Expression

The antibacterial activity and antibacterial mechanism analyses of an LRR-IG protein in the Chinese mitten crab, Eriocheir sinensis

Authors: Yi Zhang, Yunhui Bai, Qiao Shi, Bin Zhou, Mengqi Ni, Jinbin Zheng, Zhaoxia Cui

Journal: Int J Biol Macromol

PubMed ID: 36801302

Doi: 10.1016/j.ijbiomac.2023.123732

Products & Services: Proteins, Expression, Isolation and Analysis

New Monoclonal Antibodies Specific for Different Epitopes of the Spike Protein of SARS-CoV-2 and Its Major Variants: Additional Tools for a More Specific COVID-19 Diagnosis

Authors: Sabrina Mariotti, Maria Vincenza Chiantore, Raffaela Teloni, Angelo Iacobino, Antonio Capocefalo, Zuleika Michelini, Martina Borghi, Melissa Baggieri, Antonella Marchi, Paola Bucci, Silvia Gioacchini, Raffaele D'Amelio, Philip J M Brouwer, Silvia Sandini, Chiara Acchioni, Marco Sgarbanti, Antonio Di Virgilio, Felicia Grasso, Andrea Cara, Donatella Negri, Fabio Magurano, Paola Di Bonito, Roberto Nisini

Journal: Biomedicines

PubMed ID: 36831149

Doi: 10.3390/biomedicines11020610

Products & Services: Proteins, Expression, Isolation and Analysis

Hyperoxia exposure upregulates Dvl-1 and activates Wnt/β-catenin signaling pathway in newborn rat lung

Authors: Yuting Zhu, Yawen Li, Weilai Jin, Zhengying Li, Le Zhang, Yuanyuan Fang, Yanyu Zhang

Journal: BMC Mol Cell Biol

PubMed ID: 36726071

Doi: 10.1186/s12860-023-00465-6

Products & Services: Catalog Peptides

EGF‑IL2 bispecific and bivalent EGF fusion toxin efficacy against syngeneic head and neck cancer mouse models

Authors: Yue Qiu , Zeng Qi , Zhaohui Wang , Yu Cao , Ling Lu , Huiping Zhang , David Mathes , Elizabeth A Pomfret , Shi-Long Lu , Zhirui Wang

Journal: Oncol Rep

PubMed ID: 36579667

Doi: 10.3892/or.2022.8474

Products & Services: Gene Synthesis

Novel csuC-DNA nanovaccine based on chitosan candidate vaccine against infection with Acinetobacter baumannii

Authors: Eskandar Hosseinnezhad-Lazarjani, Abbas Doosti, Ali Sharifzadeh

Journal: Vaccine

PubMed ID: 36841724

Doi: 10.1016/j.vaccine.2023.02.046

Products & Services: Proteins, Expression, Isolation and Analysis

DNA aptamer-based affinity chromatography system for purification of recombinant proteins tagged with lysine tag

Authors: Klaudia Arciszewska, Ewa Kowalska, Filip Bartnicki, Piotr Bonarek, Agnieszka Katarzyna Banaś, Wojciech Strzałka

Journal: J Chromatogr A

PubMed ID: 36780846

Doi: 10.1016/j.chroma.2023.463846

Products & Services: Proteins, Expression, Isolation and Analysis

Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2

Authors: Xinxin Wang, Zhiyuan Wen, Huizhen Cao, Jie Luo, Lei Shuai, Chong Wang, Jinying Ge, Xijun Wang, Zhigao Bu, Jinliang Wang

Journal: J Virol

PubMed ID: 36779763

Doi: 10.1128/jvi.01611-22

Products & Services: Catalog Antibody

Lrpap1 (RAP) Inhibits Proximal Tubule Clathrin Mediated and Clathrin Independent Endocytosis, Ameliorating Renal Aminoglycoside Nephrotoxicity

Authors: Mark C Wagner, Ruben M Sandoval, Shiv Pratap S Yadav, Silvia B Campos, George J Rhodes, Carrie L Phillips, Bruce A Molitoris

Journal: Kidney360

PubMed ID: 36848531

Doi: 10.34067/KID.0000000000000094

Products & Services: Proteins, Expression, Isolation and Analysis

Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection

Authors: Alan T Tang, David W Buchholz, Katherine M Szigety, Brian Imbiakha, Siqi Gao, Maxwell Frankfurter, Min Wang, Jisheng Yang, Peter Hewins, Patricia Mericko-Ishizuka, N Adrian Leu, Stephanie Sterling, Isaac A Monreal, Julie Sahler, Avery August, Xuming Zhu, Kellie A Jurado, Mingang Xu, Edward E Morrisey, Sarah E Millar, Hector C Aguilar, Mark L Kahn

Journal: PLoS Biol

PubMed ID: 36745682

Doi: 10.1371/journal.pbio.3001989

Products & Services: Proteins, Expression, Isolation and Analysis

A biallelic loss of function variant in HORMAD1 within a large consanguineous Turkish family is associated with spermatogenic arrest

Authors: Ozlem Okutman, Manon Boivin, Jean Muller, Nicolas Charlet-Berguerand, Stéphane Viville

Journal: Hum Reprod

PubMed ID: 36524333

Doi: 10.1093/humrep/deac259

Products & Services: Proteins, Expression, Isolation and Analysis

Celastrol alleviates oxidative stress induced by multi-walled carbon nanotubes through the Keap1/Nrf2/HO-1 signaling pathway

Authors: Tao-Lin Qing, Lang Yan, Shao-Kang Wang, Xiao-Yu Dai, Li-Jun Ren, Ji-Qian-Zhu Zhang, Wen-Jing Shi, Xiao-Fang Zhang, Mei-Tang Wang, Ji-Kuai Chen, Jiang-Bo Zhu

Journal: Ecotoxicol Environ Saf

PubMed ID: 36774793

Doi: 10.1016/j.ecoenv.2023.114623

Products & Services: Molecular Biology Reagents

Synthesis of Bispecific Antibody Conjugates Using Functionalized Poly-ADP-ribose Polymers

Authors: Qinqin Cheng, Xiao-Nan Zhang, Jiawei Li, Jingwen Chen, Yiling Wang, Yong Zhang

Journal: Biochemistry

PubMed ID: 36821831

Doi: 10.1021/acs.biochem.2c00718

Products & Services: Molecular Biology Reagents

Multicopy suppressor screens reveal convergent evolution of single-gene lysis proteins

Authors: Benjamin A Adler, Karthik Chamakura, Heloise Carion, Jonathan Krog, Adam M Deutschbauer, Ry Young, Vivek K Mutalik, Adam P Arkin

Journal: Nat Chem Biol

PubMed ID: 36805702

Doi: 10.1038/s41589-023-01269-7

Products & Services: Plasmid DNA Preparation

The Ku complex promotes DNA end-bridging and this function is antagonized by Tel1/ATM kinase

Authors: Carlo Rinaldi, Paolo Pizzul, Erika Casari, Marco Mangiagalli, Renata Tisi, Maria Pia Longhese

Journal: Nucleic Acids Res

PubMed ID: 36762474

Doi: 10.1093/nar/gkad062

Products & Services: Gene Synthesis

Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer's disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assay

Authors: Liding Zhang, Ying Su, Xiaohan Liang, Kai Cao, Qingming Luo, Haiming Luo

Journal: Nano Res

PubMed ID: 37223429

Doi: 10.1007/s12274-022-5354-4

Products & Services: Recombinant Proteins

Glucose-Induced Enhanced Virulence in Strains of Multidrug-Resistant Pseudomonas aeruginosa Isolated from Diabetic Patients

Authors: Sarika Suresh, Akshatha Naik, Ramya Premanath

Journal: Curr Microbiol

PubMed ID: 36752926

Doi: 10.1007/s00284-023-03200-8

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DUX4 double whammy: The transcription factor that causes a rare muscular dystrophy also kills the precursors of the human nose

Authors: Kaoru Inoue, Hamed Bostan, MaKenna R Browne, Owen F Bevis, Carl D Bortner, Steven A Moore, Aaron A Stence, Negin P Martin, Shih-Heng Chen, Adam B Burkholder, Jian-Liang Li, Natalie D Shaw

Journal: Sci Adv

PubMed ID: 36800423

Doi: 10.1126/sciadv.abq7744

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PERK recruits E-Syt1 at ER-mitochondria contacts for mitochondrial lipid transport and respiration

Authors: Maria Livia Sassano, Alexander R van Vliet, Ellen Vervoort, Sofie Van Eygen, Chris Van den Haute, Benjamin Pavie, Joris Roels, Johannes V Swinnen, Marco Spinazzi, Leen Moens, Kristina Casteels, Isabelle Meyts, Paolo Pinton, Saverio Marchi, Leila Rochin, Francesca Giordano, Blanca Felipe-Abrio, Patrizia Agostinis

Journal: J Cell Biol

PubMed ID: 36821088

Doi: 10.1083/jcb.202206008

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Discovery of Novel Transketolase Epitopes and the Development of IgG-Based Tuberculosis Serodiagnostics

Authors: Jaya Talreja , Changya Peng , Tuan-Minh Nguyen , Sorin Draghici , Lobelia Samavati

Journal: Microbiology Spectrum

PubMed ID: 36651770

Doi: 10.1128/spectrum.03377-22

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A PEG-lipid-free COVID-19 mRNA vaccine triggers robust immune responses in mice

Authors: Min Li , Yixuan Huang , Jiacai Wu , Sanpeng Li , Miao Mei , Haixia Chen , Ning Wang , Weigang Wu , Boping Zhou , Xu Tan , Bin Li

Journal: Materials Horizons

PubMed ID: 36468425

Doi: 10.1039/D2MH01260J

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Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes

Authors: Amanda Fabra-García, Sophia Hailemariam, Roos M de Jong, Kirsten Janssen, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Danton Ivanochko, Anthony Semesi, Brandon McLeod, Martijn W Vos, Marloes H C de Bruijni, Judith M Bolscher, Marta Szabat, Stefanie Vogt, Lucas Kraft, Sherie Duncan, Moses R Kamya, Margaret E Feeney, Prasanna Jagannathan, Bryan Greenhouse, Koen J Dechering, Robert W Sauerwein, C Richter King, Randall S MacGill, Teun Bousema, Jean-Philippe Julien, Matthijs M Jore

Journal: Immunity

PubMed ID: 36792574

Doi: 10.1016/j.immuni.2023.01.009

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Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity

Authors: Xiaoge Gao, Pin Jiang, Xiaohuan Wei, Wei Zhang, Jiwei Zheng, Shishuo Sun, Hong Yao, Xiangye Liu, Qing Zhang

Journal: BMC Cancer

PubMed ID: 36793021

Doi: 10.1186/s12885-023-10608-9

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NRXN1 depletion in the medial prefrontal cortex induces anxiety-like behaviors and abnormal social phenotypes along with impaired neurite outgrowth in rat

Authors: Di Wu, Jiansheng Zhu, Lianghui You, Jingyu Wang, Sufen Zhang, Zhonghui Liu, Qu Xu, Xiaojie Yuan, Lei Yang, Wei Wang, Meiling Tong, Qin Hong, Xia Chi

Journal: J Neurodev Disord

PubMed ID: 36737720

Doi: 10.1186/s11689-022-09471-9

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Application of an electro elution system for direct purification of linear covalently closed DNA fragments

Authors: F Talebnia, D Pushparajah, S Chandrasekaran, S J Hersch, N Nafissi, R Slavcev

Journal: J Chromatogr B Analyt Technol Biomed Life Sci

PubMed ID: 36842293

Doi: 10.1016/j.jchromb.2023.123622

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Whole genome sequencing of Malaysian colorectal cancer patients reveals specific druggable somatic mutations

Authors: Ryia Illani Mohd Yunos, Nurul-Syakima Ab Mutalib, Jia-Shiun Khoo, Sazuita Saidin, Muhiddin Ishak, Saiful Effendi Syafruddin, Francis Yew Fu Tieng, Najwa Farhah Md Yusof, Mohd Ridhwan Abd Razak, Norshahidah Mahamad Nadzir, Nadiah Abu, Isa Md Rose, Ismail Sagap, Luqman Mazlan, Rahman Jamal

Journal: Front Mol Biosci

PubMed ID: 36866106

Doi: 10.3389/fmolb.2022.997747

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Fragment-Based Phasing of Peptidic Nanocrystals by MicroED

Authors: Logan S Richards, Maria D Flores, Claudia Millán, Calina Glynn, Chih-Te Zee, Michael R Sawaya, Marcus Gallagher-Jones, Rafael J Borges, Isabel Usón, Jose A Rodriguez

Journal: ACS Bio Med Chem Au

PubMed ID: 37096030

Doi: 10.1021/acsbiomedchemau.2c00082

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DhFIG_2, a gene of nematode-trapping fungus Dactylellina haptotyla that encodes a component of the low-affinity calcium uptake system, is required for conidiation and knob-trap formation

Authors: Xiaozhou Zhao, Yani Fan, Weiwei Zhang, Meichun Xiang, Seogchan Kang, Shunxian Wang, Xingzhong Liu

Journal: Fungal Genet Biol

PubMed ID: 36849068

Doi: 10.1016/j.fgb.2023.103782

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A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma

Authors: Xianli Du, Jing Pang, Bin Gu, Tian Si, Yan Chang, Tianqi Li, Min Wu, Zicheng Wang, Yuxia Wang, Jiannan Feng, Ning Wu, Jianghong Man, Huiyan Li, Ailing Li, Tong Zhang, Bo Wang, Xiaotao Duan

Journal: Nucleic Acids Res

PubMed ID: 36660824

Doi: 10.1093/nar/gkad002

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Mindin Activates Autophagy for Lipid Utilization and Facilitates White Spot Syndrome Virus Infection in Shrimp

Authors: Jie Gao, Ye-Jia Song, Hao Wang, Bao-Rui Zhao, Xian-Wei Wang

Journal: MBio

PubMed ID: 36779788

Doi: 10.1128/mbio.02919-22

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N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy

Authors: Hidehiko Okuma, Jeffrey M Hord, Ishita Chandel, David Venzke, Mary E Anderson, Ameya S Walimbe, Soumya Joseph, Zeita Gastel, Yuji Hara, Fumiaki Saito, Kiichiro Matsumura, Kevin P Campbell

Journal: Elife

PubMed ID: 36723429

Doi: 10.7554/eLife.82811

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Planthopper salivary sheath protein LsSP1 contributes to manipulation of rice plant defenses

Authors: Hai-Jian Huang, Yi-Zhe Wang , Li-Li Li , Hai-Bin Lu, Jia-Bao Lu, Xin Wang , Zhuang-Xin Ye , Ze-Long Zhang, Yu-Juan He, Gang Lu , Ji-Chong Zhuo , Qian-Zhuo Mao , Zong-Tao Sun , Jian-Ping Chen, Jun-Min Li , Chuan-Xi Zhang

Journal: Nat Commun .

PubMed ID: 36759625

Doi: 10.1038/s41467-023-36403-5

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Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules

Authors: Yan-Hong Ma, Xu Hong, Fang Wu, Xin-Feng Xu, Rui Li, Jin Zhong, Yao-Qi Zhou, Shu-Wen Liu, Jian Zhan, Wei Xu

Journal: Acta Pharmacol Sin

PubMed ID: 36759643

Doi: 10.1038/s41401-023-01055-0

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De novo assembled transcriptomics assisted label-free quantitative proteomics analysis reveals sex-specific proteins in the intestinal tissue of Haemaphysalis qinghaiensis

Authors: Hejia Ma, Eloiza May Galon, Yanjun Lao, Ming Kang, Xuenan Xuan, Jixu Li, Yali Sun

Journal: Infect Genet Evol

PubMed ID: 36773671

Doi: 10.1016/j.meegid.2023.105409

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Transferrin Receptor Protein 1 Is an Entry Factor for Rabies Virus

Authors: Xinxin Wang, Zhiyuan Wen, Huizhen Cao, Jie Luo, Lei Shuai, Chong Wang, Jinying Ge, Xijun Wang, Zhigao Bu, Jinliang Wang

Journal: J Virol

PubMed ID: 36779762

Doi: 10.1128/jvi.01612-22

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Lipid-induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells

Authors: Eshani Karmakar, Nabanita Das, Bidisha Mukherjee, Prosenjit Das, Satinath Mukhopadhyay, Sib Sankar Roy

Journal: Biochem Cell Biol

PubMed ID: 36787544

Doi: 10.1139/bcb-2022-0266

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BioID2 screening identifies KIAA1671 as an EPS8 proximal factor that marks sites of microvillus growth

Authors: Isabella M Gaeta, Matthew J Tyska

Journal: Mol Biol Cell

PubMed ID: 36790915

Doi: 10.1091/mbc.E22-11-0498

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Cas9-orthologue-mediated cytosine and adenine base editors recognizing NNAAAA PAM sequences

Authors: Min Li, Yuting Zhao, Xiaowen Xue, Jingli Zhong, Jianxiang Lin, Jiankui Zhou, Wenhua Yu, Jun Chen, Yunbo Qiao

Journal: Biotechnol J

PubMed ID: 36800529

Doi: 10.1002/biot.202200533

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Using a modified piggyBac transposon-combined Cre/loxP system to produce selectable reporter-free transgenic bovine mammary epithelial cells for somatic cell nuclear transfer

Authors: Guangdong Hu, Meijun Song, Yan Wang, Kexing Hao, Jing Wang, Yong Zhang

Journal: Genesis

PubMed ID: 36748563

Doi: 10.1002/dvg.23510

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Recombinant vesicular stomatitis virus-vectored vaccine induces long-lasting immunity against Nipah virus disease

Authors: Courtney Woolsey, Viktoriya Borisevich, Alyssa C Fears, Krystle N Agans, Daniel J Deer, Abhishek N Prasad, Rachel O'Toole, Stephanie L Foster, Natalie S Dobias, Joan B Geisbert, Karla A Fenton, Robert W Cross, Thomas W Geisbert

Journal: J Clin Invest

PubMed ID: 36445779

Doi: 10.1172/JCI164946

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Reaction intensification for biocatalytic production of polyphenolic natural product di-C-β-glucosides

Authors: Tuo Li, Annika J E Borg, Leo Krammer, Rolf Breinbauer, Bernd Nidetzky

Journal: Biotechnol Bioeng

PubMed ID: 36787984

Doi: 10.1002/bit.28354

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Chimeric Hepatitis B core virus-like particles harboring SARS-CoV2 epitope elicit a humoral immune response in mice

Authors: Sima Sazegari, Malihe Akbarzadeh Niaki, Alireza Afsharifar, Ali Niazi, Abdollah Derakhshandeh, Maryam Moradi Vahdat, Farshad Hemmati, Mohammad Hadi Eskandari

Journal: Microb Cell Fact

PubMed ID: 36841778

Doi: 10.1186/s12934-023-02043-z

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Evaluate the guide RNA effectiveness -mediated transient assays in

Authors: Zhibo Wang, Zachary Shea, Qi Li, Kunru Wang, Kerri Mills, Bo Zhang, Bingyu Zhao

Journal: Front Plant Sci

PubMed ID: 36890894

Doi: 10.3389/fpls.2023.1111683

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The cytoplasmic synthesis and coupled membrane translocation of eukaryotic polyphosphate by signal-activated VTC complex

Authors: Zeyuan Guan, Juan Chen, Ruiwen Liu, Yanke Chen, Qiong Xing, Zhangmeng Du, Meng Cheng, Jianjian Hu, Wenhui Zhang, Wencong Mei, Beijing Wan, Qiang Wang, Jie Zhang, Peng Cheng, Huanyu Cai, Jianbo Cao, Delin Zhang, Junjie Yan, Ping Yin, Michael Hothorn, Zhu Liu

Journal: Nat Commun

PubMed ID: 36759618

Doi: 10.1038/s41467-023-36466-4

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Chromium exposure altered metabolome and microbiome-associated with neurotoxicity in zebrafish

Authors: Tongtong Yan, Yawen Xu, Yuqi Zhu, Ping Jiang, Zhan Zhang, Lei Li, Qian Wu

Journal: J Appl Toxicol

PubMed ID: 36727205

Doi: 10.1002/jat.4440

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Delivery of spike-RBD by bacterial type three secretion system for SARS-CoV-2 vaccine development

Authors: Yuchen Zhou, Jing Qu, Xiaomeng Sun, Zhuo Yue, Yingzi Liu, Keli Zhao, Fan Yang, Jie Feng, Xiaolei Pan, Yongxin Jin, Zhihui Cheng, Liang Yang, Un-Hwan Ha, Weihui Wu, Liang Li, Fang Bai

Journal: Front Immunol

PubMed ID: 36895557

Doi: 10.3389/fimmu.2023.1129705

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The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread

Authors: A C Gomes, I A Baraniak, A Lankina, Z Moulder, P Holenya, C Atkinson, G Tang, T Mahungu, F Kern, P D Griffiths, M B Reeves

Journal: Nat Commun

PubMed ID: 36823200

Doi: 10.1038/s41467-023-36683-x

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Analysis of Bacterial Microcompartments and Shell Protein Superstructures by Confocal Microscopy

Authors: Daniel S Trettel, Wade C Winkler

Journal: Microbiol Spectr

PubMed ID: 36786617

Doi: 10.1128/spectrum.03357-22

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Identifying CDC7 as a synergistic target of chemotherapy in resistant small-cell lung cancer via CRISPR/Cas9 screening

Authors: Ling Deng, Li Yang, Shuhan Zhu, Man Li, Yu Wang, Xiaolong Cao, Qiongyao Wang, Linlang Guo

Journal: Cell Death Discov

PubMed ID: 36725843

Doi: 10.1038/s41420-023-01315-2

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Function of the bacteriophage P2 baseplate central spike Apex domain in the infection process

Authors: John-Mark Miller, Ekaterina S Knyazhanskaya, Sergii A Buth, Nikolai S Prokhorov, Petr G Leiman

Journal: biorxiv

PubMed ID: 36865152

Doi: 10.1101/2023.02.25.529910

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Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment

Authors: Robin M Hallett, Ester Bonfill-Teixidor, Raffaella Iurlaro, Alexandra Arias, Swetha Raman, Peter Bayliss, Olga Egorova, Almudena Neva-Alejo, Aj Robert McGray, Esther Lau, Alexandre Bosch, Melissa Beilschmidt, Dorothea Maetzel, Johan Fransson, Isabel Huber-Ruano, Judit Anido, Jean-Philippe Julien, Patricia Giblin, Joan Seoane

Journal: Clin Cancer Res

PubMed ID: 36441800

Doi: 10.1158/1078-0432.CCR-21-1888

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Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury

Authors: Jie Chang, Zhanyang Qian, Binyu Wang, Jiang Cao, Sheng Zhang, Fan Jiang, Renyi Kong, Xiao Yu, Xiaojian Cao, Lei Yang, Hongtao Chen

Journal: Cell Commun Signal

PubMed ID: 36797790

Doi: 10.1186/s12964-022-01036-6

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Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapy

Authors: Natalia Plewa, Lucia Poncette, Thomas Blankenstein

Journal: J Immunother Cancer

PubMed ID: 36822673

Doi: 10.1136/jitc-2022-006001

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The SpACE-CCM: A facile and versatile cell culture medium-based biosensor for detection of SARS-CoV-2 spike-ACE2 interaction

Authors: Youngwook Ham, Nam-Chul Cho, Daeyong Kim, Jung-Hee Kim, Min Ju Jo, Min Seon Jeong, Bo-Yeong Pak, Sanghyeok Lee, Mi-Kyung Lee, Seung-Wook Chi, Tae-Don Kim, Nak Cheol Jeong, Sungchan Cho

Journal: Biosens Bioelectron

PubMed ID: 36827795

Doi: 10.1016/j.bios.2023.115169

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Tuning the Microenvironment to Create Functionally Distinct Mesenchymal Stromal Cell Spheroids

Authors: Victoria L Thai, Diego O Candelas, J Kent Leach

Journal: Ann Biomed Eng

PubMed ID: 36809393

Doi: 10.1007/s10439-023-03162-9

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