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A short-chain carbonyl reductase mutant is an efficient catalyst in the production of (R)-1,3-butanediol

Authors: Xiaoyan Guo, Yunfang Gao, Fangzheng Liu, Yong Tao, Haibo Jin, Jianjun Wang, Sheng Wu

Journal: Microb Biotechnol

PubMed ID: 36946330

Doi: 10.1111/1751-7915.14249

Products & Services: Molecular Biology Reagents

Production of neutralizing antibody fragment variants in the cytoplasm of E coli for rapid screening: SARS-CoV-2 a case study

Authors: Aatir A Tungekar, Rosario Recacha, Lloyd W Ruddock

Journal: Sci Rep

PubMed ID: 36927743

Doi: 10.1038/s41598-023-31369-2

Products & Services: Molecular Biology Reagents

Identification of specific and shared epitopes at the extreme N-terminal VP1 of Coxsackievirus A4, A2 and A5 by monoclonal antibodies

Authors: Yu-Xuan Tian, Wei-Ping Jin, Zhen-Ni Wei, Shi-Yun Lv, Meng-Jun Wang, Sheng-Li Meng, Jing Guo, Ze-Jun Wang, Shuo Shen

Journal: Virus Res

PubMed ID: 36805409

Doi: 10.1016/j.virusres.2023.199074

Products & Services: Peptide Synthesis

PF-D-Trimer, a protective SARS-CoV-2 subunit vaccine: immunogenicity and application

Authors: Zhihao Zhang, Jinhu Zhou, Peng Ni, Bing Hu, Normand Jolicoeur, Shuang Deng, Qian Xiao, Qian He, Gai Li, Yan Xia, Mei Liu, Cong Wang, Zhizheng Fang, Nan Xia, Zhe-Rui Zhang, Bo Zhang, Kun Cai, Yan Xu, Binlei Liu

Journal: npj Vaccines

PubMed ID: 36922524

Doi: 10.1038/s41541-023-00636-8

Products & Services: Gene Synthesis

Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway

Authors: Yu Jiang, Xiyuan Li, Fenghui Qian, Bingbing Sun, Xiyuan Wang, Yan Zhang, Deqiang Zhang, Meiyu Geng, Zuoquan Xie, Sheng Yang

Journal: Research (Wash D C)

PubMed ID: 37011280

Doi: 10.34133/research.0102

Products & Services: Gene Synthesis

The diurnal salivary glands transcriptome of Dermacentor nuttalli from the first four days of blood feeding

Authors: Hejia Ma, Yanjun Lao, Susu Liu, Jingkai Ai, Xue Sun, Wei Zhang, Ming Kang, Jixu Li, Yali Sun

Journal: Ticks Tick Borne Dis

PubMed ID: 37001418

Doi: 10.1016/j.ttbdis.2023.102178

Products & Services: PCR Cloning and Subcloning

Ferulic Acid Alleviates Hepatic Lipid Accumulation and Inflammation by Improving Proximal and Distal Intestinal Barriers in NAFLD Mice

Authors: Jiaojiao Fu, Jingyan Yang, Liying He, Caixia Yang, Jing He, Yanan Hua, Jinlin Guo, Sijing Liu

Journal: Tohoku J Exp Med

PubMed ID: 36927682

Doi: 10.1620/tjem.2023.J023

Products & Services: Molecular Biology Reagents

Urease of Aspergillus fumigatus Is Required for Survival in Macrophages and Virulence

Authors: Zhenzhen Xiong, Nan Zhang, Liru Xu, Zhiduo Deng, Jarukitt Limwachiranon, Yaojie Guo, Yi Han, Wei Yang, Daniel H Scharf

Journal: Microbiol Spectr

PubMed ID: 36916906

Doi: 10.1128/spectrum.03508-22

Products & Services: Proteins, Expression, Isolation and Analysis

Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases

Authors: George D Lampe, Rebeca T King, Tyler S Halpin-Healy, Sanne E Klompe, Marcus I Hogan, Phuc Leo H Vo, Stephen Tang, Alejandro Chavez, Samuel H Sternberg

Journal: Nat Biotechnol

PubMed ID: 36991112

Doi: 10.1038/s41587-023-01748-1

Products & Services: Gene Synthesis

Alphaherpesvirus upregulates NDRG1 expression to facilitate the nuclear import of viral UL31 and UL34 proteins

Authors: Shuang Zhang, Sheng-Li Ming, Lei Zeng, Lu-Fang Wang, Chao Zhang, He-Shui Zhu, Guo-Yu Yang, Gai-Ping Zhang, Bei-Bei Chu, Jiang Wang

Journal: J Med Virol

PubMed ID: 36807585

Doi: 10.1002/jmv.28591

Products & Services: Proteins, Expression, Isolation and Analysis

Novel multi-epitope vaccine against bovine brucellosis: approach from immunoinformatics to expression

Authors: Somayyeh Rahimnahal, Shahnaz Yousefizadeh, Yahya Mohammadi

Journal: J Biomol Struct Dyn

PubMed ID: 36927475

Doi: 10.1080/07391102.2023.2188962

Products & Services: Proteins, Expression, Isolation and Analysis

Entropy-driven assisted T7 RNA polymerase amplification-activated CRISPR/Cas13a activity for SARS-CoV-2 detection in human pharyngeal swabs and environment by an electrochemiluminescence biosensor

Authors: Jihua Wei, Zichun Song, Jiuying Cui, Yuanxun Gong, Qianli Tang, Kai Zhang, Xinlei Song, Xianjiu Liao

Journal: J Hazard Mater

PubMed ID: 36965355

Doi: 10.1016/j.jhazmat.2023.131268

Products & Services: Proteins, Expression, Isolation and Analysis

Exploring the structural basis to develop efficient multi-epitope vaccines displaying interaction with HLA and TAP and TLR3 molecules to prevent NIPAH infection, a global threat to human health

Authors: Sukrit Srivastava, Sonia Verma, Mohit Kamthania, Ajay Kumar Saxena, Kailash C Pandey, Veena Pande, Michael Kolbe

Journal: PLoS ONE

PubMed ID: 36920996

Doi: 10.1371/journal.pone.0282580

Products & Services: Proteins, Expression, Isolation and Analysis

Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge

Authors: Ebony N Gary, Nicholas J Tursi, Bryce M Warner, Gina Cuismano, Jennifer Connors, Elizabeth M Parzych, Bryan D Griffin, Matthew R Bell, Ali R Ali, Drew Frase, Casey E Hojecki, Gabriela A Canziani, Irwin Chaiken, Toshitha Kannan, Estella Moffat, Carissa Embury-Hyatt, Sarah K Wooton, Andrew Kossenkov, Ami Patel, Darwyn Kobasa, Michele A Kutzler, Elias K Haddad, David B Weiner

Journal: Front Immunol

PubMed ID: 36999023

Doi: 10.3389/fimmu.2023.1138609

Products & Services: Molecular Biology Reagents

Active Site Aromatic Residues Play a Dual Role in the Substrate Interaction and Protein Structure in Functional Dimers of CYP121A1 of

Authors: Christopher S Campomizzi, Amit Kumar, Patil Pranita Uttamrao, Jack J Stallone, George E Ghanatios, Thenmalarchelvi Rathinavelan, D Fernando Estrada

Journal: ACS Infect Dis

PubMed ID: 36976833

Doi: 10.1021/acsinfecdis.2c00531

Products & Services: Proteins, Expression, Isolation and Analysis

High Autophagy Patterns in Swelling Platelets During Apheresis Platelet Storage

Authors: Lu Yu, Shifang Yu, Yunlei He, Gang Deng, Qiang Li

Journal: Indian J Hematol Blood Transfus

PubMed ID: 37790743

Doi: 10.1007/s12288-023-01638-1

Products & Services: Proteins, Expression, Isolation and Analysis

A chemically controlled Cas9 switch enables temporal modulation of diverse effectors

Authors: Cindy T Wei, Nicholas A Popp, Omri Peleg, Rachel L Powell, Elhanan Borenstein, Dustin J Maly, Douglas M Fowler

Journal: Nat Chem Biol

PubMed ID: 36879061

Doi: 10.1038/s41589-023-01278-6

Products & Services: Codon Optimization

Antitumor effect of neoantigen-reactive T cells combined with PD1 inhibitor therapy in mouse lung cancer

Authors: Huan Qin, Haiyan Hu, Ximing Liao, Pei Zhao, Wenjuan He, Xiaoping Su, Jiaxing Sun, Qiang Li

Journal: J Cancer Res Clin Oncol

PubMed ID: 36933035

Doi: 10.1007/s00432-023-04683-5

Products & Services: Peptide Synthesis

Authors: Sarah Temmam, Xavier Montagutelli, Cécile Herate, Flora Donati, Béatrice Regnault, Mikael Attia, Eduard Baquero Salazar, Delphine Chretien, Laurine Conquet, Grégory Jouvion, Juliana Pipoli Da Fonseca, Thomas Cokelaer, Faustine Amara, Francis Relouzat, Thibaut Naninck, Julien Lemaitre, Nathalie Derreudre-Bosquet, Quentin Pascal, Massimiliano Bonomi, Thomas Bigot, Sandie Munier, Felix A Rey, Roger Le Grand, Sylvie van der Werf, Marc Eloit

Journal: EMBO Rep

PubMed ID: 36876574

Doi: 10.15252/embr.202256055

Products & Services: Recombinant Proteins

Design of a stabilized RBD enables potently neutralizing SARS-CoV-2 single-component nanoparticle vaccines

Authors: Thayne H Dickey, Rui Ma, Sachy Orr-Gonzalez, Tarik Ouahes, Palak Patel, Holly McAleese, Brandi Butler, Elizabeth Eudy, Brett Eaton, Michael Murphy, Jennifer L Kwan, Nichole D Salinas, Michael R Holbrook, Lynn E Lambert, Niraj H Tolia

Journal: Cell Rep

PubMed ID: 36943870

Doi: 10.1016/j.celrep.2023.112266

Products & Services: Recombinant Proteins

On the design of a constitutively active peptide asparaginyl ligase for facile protein conjugation

Authors: Niying Chua, Yee Hwa Wong, Abbas El Sahili, Chuan Fa Liu, Julien Lescar

Journal: FEBS Open Bio

PubMed ID: 36788723

Doi: 10.1002/2211-5463.13575

Products & Services: Peptide Synthesis

RHINO restricts MMEJ activity to mitosis

Authors: Alessandra Brambati, Olivia Sacco, Sarina Porcella, Joshua Heyza, Mike Kareh, Jens C Schmidt, Agnel Sfeir

Journal: biorxiv

PubMed ID: 36993461

Doi: 10.1101/2023.03.16.532763

Products & Services: Recombinant Proteins

Myosin-X recruits lamellipodin to filopodia tips

Authors: Ana Popović, Mitro Miihkinen, Sujan Ghimire, Rafael Saup, Max L B Grönloh, Neil J Ball, Benjamin T Goult, Johanna Ivaska, Guillaume Jacquemet

Journal: J Cell Sci

PubMed ID: 36861887

Doi: 10.1242/jcs.260574

Products & Services: Gene Synthesis

Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders

Authors: Elżbieta Wątor , Piotr Wilk , Artur Biela, Michał Rawski , Krzysztof M Zak, Wieland Steinchen , Gert Bange, Sebastian Glatt , Przemysław Grudnik

Journal: Nature Communications

PubMed ID: 36973244

Doi: 10.1038/s41467-023-37305-2

Products & Services: Gene Synthesis Gene Synthesis

Mucus-penetrating nonviral gene vaccine processed in the epithelium for inducing advanced vaginal mucosal immune responses

Authors: Qunjie Bi, Xu Song, Yangyang Zhao, Xueyi Hu, Huan Yang, Rongrong Jin, Yu Nie

Journal: Acta Pharmacuetica Sinica.B

PubMed ID: 36970203

Doi: 10.1016/j.apsb.2022.11.004

Products & Services: Peptide Synthesis

A riboswitch separated from its ribosome-binding site still regulates translation

Authors: Griffin M Schroeder, Olayinka Akinyemi, Jeffrey Malik, Caroline M Focht, Elizabeth M Pritchett, Cameron D Baker, James P McSally, Jermaine L Jenkins, David H Mathews, Joseph E Wedekind

Journal: Nucleic Acids Research

PubMed ID: 36762498

Doi: 10.1093/nar/gkad056.

Products & Services: Gene Synthesis

A swapped genetic code prevents viral infections and gene transfer

Authors: Akos Nyerges, Svenja Vinke, Regan Flynn, Siân V Owen, Eleanor A Rand, Bogdan Budnik, Eric Keen, Kamesh Narasimhan, Jorge A Marchand, Maximilien Baas-Thomas, Min Liu, Kangming Chen, Anush Chiappino-Pepe, Fangxiang Hu, Michael Baym, George M Church

Journal: Nature

PubMed ID: 36922599

Doi: 10.1038/s41586-023-05824-z

Products & Services: Gene Synthesis

New insights underlying the early events of dopaminergic dysfunction in Parkinson’s Disease

Authors: Hannah L. Dela Cruz, Esther L. Dela Cruz, Cody J. Zurhellen, Herbert T. York, Jim A. Baun, Joshua L. Dela Cruz, Jay S. Dela Cruz

Journal: biorxiv

Doi: 10.1101/2020.09.27.313957

Products & Services: Endotoxin Detection & Removal System

The Trypanosoma brucei MISP family of invariant proteins is co-expressed with BARP as triple helical bundle structures on the surface of salivary gland forms, but is dispensable for parasite development within the tsetse vector

Authors: Aitor Casas-Sanchez, Raghavendran Ramaswamy, Samïrah Perally, Lee R Haines, Clair Rose, Marcela Aguilera-Flores, Susana Portillo, Margot Verbeelen, Shahid Hussain, Laura Smithson, Cristina Yunta, Michael J Lehane, Sue Vaughan, Jan van den Abbeele, Igor C Almeida, Martin J Boulanger, Álvaro Acosta-Serrano

Journal: PLoS Pathog

PubMed ID: 36996244

Doi: 10.1371/journal.ppat.1011269

Products & Services: Proteins, Expression, Isolation and Analysis

Highly Sensitive and Selective Detection of Inorganic Phosphates in the Water Environment by Biosensors Based on Bioluminescence Resonance Energy Transfer

Authors: Jie Yu, Yan Zhang, Yanping Zhao, Xuxiang Zhang, Hongqiang Ren

Journal: Anal Chem

PubMed ID: 36942460

Doi: 10.1021/acs.analchem.2c04748

Products & Services: Proteins, Expression, Isolation and Analysis

Peptides that Mimic RS repeats modulate phase separation of SRSF1, revealing a reliance on combined stacking and electrostatic interactions

Authors: Talia Fargason, Naiduwadura Ivon Upekala De Silva, Erin King, Zihan Zhang, Trenton Paul, Jamal Shariq, Steve Zaharias, Jun Zhang

Journal: Elife

PubMed ID: 36862748

Doi: 10.7554/eLife.84412

Products & Services: Molecular Biology Reagents

Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment

Authors: Christine McInnis, Shilpa Bhatia, Brinda Vijaykumar, Qiaomu Tian, Yanbo Sun, Del Leistritz-Edwards, Charles T Quinn, Ravi Uppaluri, Ann Marie Egloff, Lakshmi Srinivasan, Daniel C Pregibon, Anthony J Coyle, Glenn J Hanna

Journal: J Immunother Cancer

PubMed ID: 36990508

Doi: 10.1136/jitc-2023-006721

Products & Services: Peptide Synthesis

Interaction of SARS-CoV-2 Nucleocapsid Protein and Human RNA Helicases DDX1 and DDX3X Modulates Their Activities on Double-Stranded RNA

Authors: Camilla Lodola, Massimiliano Secchi, Virginia Sinigiani, Antonella De Palma, Rossana Rossi, Davide Perico, Pier Luigi Mauri, Giovanni Maga

Journal: Int J Mol Sci

PubMed ID: 36982856

Doi: 10.3390/ijms24065784

Products & Services: Plasmid DNA Preparation

Genetically engineered CXCR4-modified exosomes for delivery of miR-126 mimics to macrophages alleviate periodontitis

Authors: Haotian Luo, Danying Chen, Ruoyu Li, Runze Li, Yungshan Teng, Yang Cao, Xuenong Zou, Weicai Wang, Chen Zhou

Journal: J Nanobiotechnology

PubMed ID: 36991451

Doi: 10.1186/s12951-023-01863-w

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of Three Human POLH Germline Variants Defective in Complementing the UV- and Cisplatin-Sensitivity of POLH-Deficient Cells

Authors: Mina Yeom, Jin-Kyung Hong, Joo-Ho Shin, Yunjong Lee, Frederick Peter Guengerich, Jeong-Yun Choi

Journal: Int J Mol Sci

PubMed ID: 36982269

Doi: 10.3390/ijms24065198

Products & Services: Custom DNA/RNA Oligos

The Influence of Protein Charge and Molecular Weight on the Affinity of Aptamers

Authors: Alissa Drees, Tung Lam Trinh, Markus Fischer

Journal: Pharmaceuticals (Basel)

PubMed ID: 36986556

Doi: 10.3390/ph16030457

Products & Services: Custom DNA/RNA Oligos

Dissection of Antibody Responses of Gam-COVID-Vac-Vaccinated Subjects Suggests Involvement of Epitopes Outside RBD in SARS-CoV-2 Neutralization

Authors: Maria Byazrova, Pia Gattinger, Ekaterina Astakhova, Gerhard Hofer, Musa Khaitov, Alexander Filatov, Rudolf Valenta

Journal: Int J Mol Sci

PubMed ID: 36982183

Doi: 10.3390/ijms24065104

Products & Services: Recombinant Antibody Expression

Genome-wide identification and characterization of tomato 14–3-3 (SlTFT) genes and functional analysis of SlTFT6 under heat stress

Authors: Yunfei Liang, Fang Ma, Ruili Zhang, Wenyu Li, Jiao Dang, Huai Su, Boyu Li, Tixu Hu, Mingke Zhang, Yan Liang, Xiangqiang Zhan

Journal: Physiologia plantarum

PubMed ID: 36906839

Doi: 10.1111/ppl.13888

Products & Services: Transient Expression(INACTIVE)

Development and Evaluation of Recombinant B-Cell Multi-Epitopes of PDHA1 and GAPDH as Subunit Vaccines against Infection in Flounder ()

Authors: Xiuzhen Sheng, Honghua Zhang, Min Liu, Xiaoqian Tang, Jing Xing, Heng Chi, Wenbin Zhan

Journal: Vaccines (Basel)

PubMed ID: 36992208

Doi: 10.3390/vaccines11030624

Products & Services: Peptide Synthesis

To Explore the Binding Affinity of Human γ-Secretase Activating Protein (GSAP) Isoform 4 with APP-C99 Peptides

Authors: Deekshi Angira, Sonali Chaudhary, Arumugam Abiramasundari, Vijay Thiruvenkatam

Journal: ACS Omega

PubMed ID: 37065030

Doi: 10.1021/acsomega.3c01117

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of Filamin A Mechanobinding Partner III: SAV1 Specifically Interacts with Filamin A Mechanosensitive Domain 21

Authors: Huaguan Zhang, Zhenfeng Mao, Ziwei Yang, Fumihiko Nakamura

Journal: Biochemistry

PubMed ID: 36857526

Doi: 10.1021/acs.biochem.2c00665

Products & Services: Molecular Biology Reagents

Virus-like Magnetic Mesoporous Silica Particles as a Universal Vaccination Platform against Pathogenic Infections

Authors: Mingyang Liu, Yan Zhao, Zhishang Shi, Jeffrey I Zink, Qilin Yu

Journal: ACS Nano

PubMed ID: 36961475

Doi: 10.1021/acsnano.3c00644

Products & Services: Gene Synthesis

Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants

Authors: Bin Ju, Qi Zhang, Ziyi Wang, Zhen Qin Aw, Peng Chen, Bing Zhou, Ruoke Wang, Xiangyang Ge, Qining Lv, Lin Cheng, Rui Zhang, Yi Hao Wong, Huixin Chen, Haiyan Wang, Sisi Shan, Xuejiao Liao, Xuanling Shi, Lei Liu, Justin Jang Hann Chu, Xinquan Wang, Zheng Zhang, Linqi Zhang

Journal: Nat Immunol

PubMed ID: 36914890

Doi: 10.1038/s41590-023-01449-6

Products & Services: DNA Sequencing

Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex

Authors: Peng Liu, Tian Xie, Xinyue Wu, Gongshe Han, Sita D Gupta, Zike Zhang, Jian Yue, Feitong Dong, Kenneth Gable, Somashekarappa Niranjanakumari, Wanyuan Li, Lin Wang, Wenchen Liu, Ruifeng Yao, Edgar B Cahoon, Teresa M Dunn, Xin Gong

Journal: SCIENCE ADVANCES

PubMed ID: 36989369

Doi: 10.1126/sciadv.adg0728

Products & Services: Proteins, Expression, Isolation and Analysis

Engineered production of isoprene from the model green microalga Chlamydomonas reinhardtii

Authors: Razan Z Yahya, Gordon B Wellman, Sebastian Overmans, Kyle J Lauersen

Journal: Metab Eng Commun .

PubMed ID: 37006831

Doi: 10.1016/j.mec.2023.e00221

Products & Services: Gene Synthesis

Epinecidin-1, a marine antifungal peptide, inhibits Botrytis cinerea and delays gray mold in postharvest peaches

Authors: Li Fan , Yingying Wei , Yi Chen , Shu Jiang , Feng Xu , Chundan Zhang , Hongfei Wang , Xingfeng Shao

Journal: Food Chem .

PubMed ID: 36191421

Doi: 10.1016/j.foodchem.2022.134419

Products & Services: Peptide Synthesis

Fabrication of bFGF/polydopamine-loaded PEEK implants for improving soft tissue integration by upregulating Wnt/β-catenin signaling

Authors: Xiaohu Wang, Ning Ma, Li Feng, Mingkui Shen, Yaqi Zhou, Xinan Zhang, Ruichao Huang, Li Zhou, Shanfeng Ji, Yongli Lou, Zhi Zhu

Journal: Heliyon

PubMed ID: 37012909

Doi: 10.1016/j.heliyon.2023.e14800

Products & Services: Proteins, Expression, Isolation and Analysis

Purification and biochemical characterization of a novel chitosanase cloned from the gene of Kitasatospora setae KM-6054 and its application in the production of chitooligosaccharides

Authors: Yinxiao Xu, Hui Wang, Benwei Zhu, Zhong Yao, Ling Jiang

Journal: World J Microbiol Biotechnol

PubMed ID: 36905451

Doi: 10.1007/s11274-023-03561-z

Products & Services: Proteins, Expression, Isolation and Analysis

Regenerative marine waste towards CaCO nanoformulation for Alzheimer's therapy

Authors: Prakashkumar Nallasamy, Beema Shafreen Rajamohamed, Jeyakanthan Jeyaraman, Brindhadevi Kathirvel, Suganthy Natarajan

Journal: Environ Res

PubMed ID: 36889568

Doi: 10.1016/j.envres.2023.115631

Products & Services: Peptide Synthesis

Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells

Authors: Yusman Manchanda, Stavroula Bitsi, Shiqian Chen, Johannes Broichhagen, Jorge Bernardino de la Serna, Ben Jones, Alejandra Tomas

Journal: Endocrinology

PubMed ID: 36774542

Doi: 10.1210/endocr/bqad028

Products & Services: Molecular Biology Reagents

DELLA functions evolved by rewiring of associated transcriptional networks

Authors: Asier Briones-Moreno, Jorge Hernández-García, Carlos Vargas-Chávez, Noel Blanco-Touriñán, Alexandros Phokas, Cristina Úrbez, Pablo D Cerdán, Juliet C Coates, David Alabadí, Miguel A Blázquez

Journal: Nat Plants

PubMed ID: 36914897

Doi: 10.1038/s41477-023-01372-6

Products & Services: Gene Synthesis

Inflammatory stimulation of astrocytes affects the expression of miRNA-22-3p within NSCs-EVs regulating remyelination by targeting KDM3A

Authors: Tianyu Han, Peiwen Song, Zuomeng Wu, Cancan Wang, Yunlei Liu, Wang Ying, Kaixuan Li, Cailiang Shen

Journal: Stem Cell Res Ther

PubMed ID: 36959678

Doi: 10.1186/s13287-023-03284-w

Products & Services: Molecular Biology Reagents

The force-dependent filamin A-G3BP1 interaction regulates phase-separated stress granule formation

Authors: Ziyi Feng, Zhenfeng Mao, Ziwei Yang, Xiaowei Liu, Fumihiko Nakamura

Journal: J Cell Sci

PubMed ID: 36806943

Doi: 10.1242/jcs.260684

Products & Services: Proteins, Expression, Isolation and Analysis

Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel

Authors: Mingfeng Zhang, Yuanyue Shan, Duanqing Pei

Journal: nature COMMUNICATION

PubMed ID: 36928654

Doi: 10.1038/s41467-023-37204-6

Products & Services: Nucleic Acid Purification & Analysis

Single-Molecule Interconversion between Chiral Configurations of Boronate Esters Observed in a Nanoreactor

Authors: Xiaoyu Du, Shanyu Zhang, Liying Wang, Yuqin Wang, Pingping Fan, Wendong Jia, Panke Zhang, Shuo Huang

Journal: ACS Nano

PubMed ID: 36655995

Doi: 10.1021/acsnano.2c11286

Products & Services: Plasmid DNA Preparation

The activation mechanism and antibody binding mode for orphan GPR20

Authors: Xi Lin, Shan Jiang, Yiran Wu, Xiaohu Wei, Gye-Won Han, Lijie Wu, Junlin Liu, Bo Chen, Zhibin Zhang, Suwen Zhao, Vadim Cherezov, Fei Xu

Journal: Cell Discovery

PubMed ID: 36849514

Doi: 10.1038/s41421-023-00520-8

Products & Services: Gene Synthesis

Barrier properties of Nup98 FG phases ruled by FG motif identity and inter-FG spacer length

Authors: Sheung Chun Ng, Abin Biswas, Trevor Huyton, Jürgen Schünemann, Simone Reber, Dirk Görlich

Journal: Nat Commun

PubMed ID: 36765044

Doi: 10.1038/s41467-023-36331-4

Products & Services: Proteins, Expression, Isolation and Analysis

Safety and Immunogenicity of Betuvax-CoV-2, an RBD-Fc-Based SARS-CoV-2 Recombinant Vaccine: Preliminary Results of the First-in-Human, Randomized, Double-Blind, Placebo-Controlled Phase I/II Clinical Trial

Authors: Aleksandr V Kudriavtsev, Anna V Vakhrusheva, Nickolay A Kryuchkov, Maria E Frolova, Konstantin A Blagodatskikh, Taras V Ivanishin, Milana Djonovic, Ekaterina A Romanovskaya-Romanko, Anton N Kovalenko, Dmitry A Lioznov, Tatiana G Zubkova, Svetlana V Teplykh, Rodion A Oseshnyuk, Marina A Stukova, Artur A Isaev, Igor V Krasilnikov

Journal: Vaccines (Basel)

PubMed ID: 36851204

Doi: 10.3390/vaccines11020326

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of cross-reactive monoclonal antibodies against SARS-CoV-1 and SARS-CoV-2: Implication for rational design and development of pan-sarbecovirus vaccines and neutralizing antibodies

Authors: Shibo Li, Jianbo Wu, Weiyu Jiang, Haiyan He, Yunjiao Zhou, Wei Wu, Yidan Gao, Minxiang Xie, Anqi Xia, Jiaying He, Qianqian Zhang, Yuru Han, Nan Wang, Guangqi Zhu, Qiujing Wang, Zheen Zhang, Christian T Mayer, Kang Wang, Xiangxi Wang, Junqing Wang, Zhenguo Chen, Shibo Jiang, Lei Sun, Rong Xia, Qiao Wang

Journal: J Med Virol

PubMed ID: 36573441

Doi: 10.1002/jmv.28440

Products & Services: Molecular Biology Reagents

Acid-Responsive Immune-Enhancing Chitosan Formulation Capable of Transforming from Particle Stabilization to Polymer Chain Stabilization

Authors: Yongjuan Zou, Xiaoxuan Liu, Qiuting Chen, Hiroyuki Oku, Guanghui Ma, Jie Wu

Journal: ACS Appl Mater Interfaces

PubMed ID: 36825996

Doi: 10.1021/acsami.2c17505

Products & Services: Proteins, Expression, Isolation and Analysis

Connection between MHC class II binding and aggregation propensity: The antigenic peptide 10 of as a benchmark study

Authors: Rodrigo Ochoa, Thyago R Cardim-Pires, Ricardo Sant'Anna, Pilar Cossio, Debora Foguel

Journal: Comput Struct Biotechnol J

PubMed ID: 36890879

Doi: 10.1016/j.csbj.2023.02.031

Products & Services: Molecular Biology Reagents

Antibody isotype epitope mapping of SARS-CoV-2 Spike RBD protein: Targets for COVID-19 symptomatology and disease control

Authors: Marinela Contreras, Joaquín Vicente, José Joaquín Cerón, Silvia Martinez Subiela, José Miguel Urra, Francisco J Rodríguez-Del-Río, Elisa Ferreras-Colino, Rita Vaz-Rodrigues, Isabel G de Fernández de Mera, Sandra Antunes, Ana Domingos, Christian Gortázar, José de la Fuente

Journal: Eur J Immunol

PubMed ID: 36658749

Doi: 10.1002/eji.202250206

Products & Services: Molecular Biology Reagents

Smartphone-based chemiluminescence detection of aflatoxin B via labelled and label-free dual sensing systems

Authors: Junning Ma, Yue Guan, Fuguo Xing, Yan Wang, Xu Li, Qiang Yu, Xiaohua Yu

Journal: Food Chem

PubMed ID: 36796268

Doi: 10.1016/j.foodchem.2023.135654

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Generation and characterization of an immunodeficient mouse model of mucopolysaccharidosis type II

Authors: Miles C Smith, Lalitha R Belur, Andrea D Karlen, Kelly Podetz-Pedersen, Olivia Erlanson, Kanut Laoharawee, Justin Furcich, Troy C Lund, Yun You, Davis Seelig, Beau R Webber, R Scott McIvor

Journal: Mol Genet Metab

PubMed ID: 37023503

Doi: 10.1016/j.ymgme.2023.107539

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The molecular mechanism of light-induced bond formation and breakage in the cyanobacteriochrome TePixJ

Authors: Jeannette Ruf, Flavia Bindschedler, David Buhrke

Journal: Phys Chem Chem Phys

PubMed ID: 36752541

Doi: 10.1039/d2cp05856a

Products & Services: Proteins, Expression, Isolation and Analysis

The molecular chaperone cysteine string protein is required for monomeric SNARE proteins to assemble in trans-complexes during human sperm acrosomal exocytosis†

Authors: Karina Flores-Montero, María Victoria Berberián, Luis Segundo Mayorga, Claudia Nora Tomes, María Celeste Ruete

Journal: Biol Reprod

PubMed ID: 36308432

Doi: 10.1093/biolre/ioac196

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of a TatA/TatB binding site on the TatC component of the twin arginine translocase

Authors: Emmanuele Severi, Mariana Bunoro Batista, Adelie Lannoy, Phillip J Stansfeld, Tracy Palmer

Journal: Microbiology (Reading)

PubMed ID: 36790402

Doi: 10.1099/mic.0.001298

Products & Services: Proteins, Expression, Isolation and Analysis

CriSNPr, a single interface for the curated and de novo design of gRNAs for CRISPR diagnostics using diverse Cas systems

Authors: Asgar H Ansari, Manoj Kumar, Sajal Sarkar, Souvik Maiti, Debojyoti Chakraborty

Journal: Elife

PubMed ID: 36752591

Doi: 10.7554/eLife.77976

Products & Services: Proteins, Expression, Isolation and Analysis

Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit

Authors: Jonah Elliff, Aparna Biswas, Poonam Roshan, Sahiti Kuppa, Angela Patterson, Jenna Mattice, Mathivanan Chinnaraj, Ryan Burd, Sarah E Walker, Nicola Pozzi, Edwin Antony, Brian Bothner, Sofia Origanti

Journal: Nucleic Acids Res

PubMed ID: 36651285

Doi: 10.1093/nar/gkac1266

Products & Services: Proteins, Expression, Isolation and Analysis

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

Authors: Romain Rouet, Jake Y Henry, Matt D Johansen, Meghna Sobti, Harikrishnan Balachandran, David B Langley, Gregory J Walker, Helen Lenthall, Jennifer Jackson, Stephanie Ubiparipovic, Ohan Mazigi, Peter Schofield, Deborah L Burnett, Simon H J Brown, Marianne Martinello, Bernard Hudson, Nicole Gilroy, Jeffrey J Post, Anthony Kelleher, Hans-Martin Jäck, Christopher C Goodnow, Stuart G Turville, William D Rawlinson, Rowena A Bull, Alastair G Stewart, Philip M Hansbro, Daniel Christ

Journal: Nat Commun

PubMed ID: 36755042

Doi: 10.1038/s41467-023-36295-5

Products & Services: Proteins, Expression, Isolation and Analysis

KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/β-Catenin Signaling Pathway

Authors: Ying Li, Yu Wang, Qinguang Zou, Shouqing Li, Fan Zhang

Journal: Lab Invest

PubMed ID: 36827869

Doi: 10.1016/j.labinv.2023.100078

Products & Services: Proteins, Expression, Isolation and Analysis

Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine

Authors: Thayne H Dickey, Richi Gupta, Holly McAleese, Tarik Ouahes, Sachy Orr-Gonzalez, Rui Ma, Olga Muratova, Nichole D Salinas, Jen C C Hume, Lynn E Lambert, Patrick E Duffy, Niraj H Tolia

Journal: npj Vaccines

PubMed ID: 36808125

Doi: 10.1038/s41541-023-00619-9

Products & Services: Proteins, Expression, Isolation and Analysis

Structure and dynamics of the EGFR/HER2 heterodimer

Authors: Xue Bai, Pengyu Sun, Xinghao Wang, Changkun Long, Shuyun Liao, Song Dang, Shangshang Zhuang, Yongtao Du, Xinyi Zhang, Nan Li, Kangmin He, Zhe Zhang

Journal: Cell Discov

PubMed ID: 36781849

Doi: 10.1038/s41421-023-00523-5

Products & Services: Proteins, Expression, Isolation and Analysis

Epitopes in the Glycosylphosphatidylinositol Attachment Signal Peptide of Trypanosoma cruzi Mucin Proteins Generate Robust but Delayed and Nonprotective CD8+ T Cell Responses

Authors: Molly E Bunkofske, Natasha Perumal, Brooke White, Eva-Maria Strauch, Rick Tarleton

Journal: J Immunol

PubMed ID: 36603035

Doi: 10.4049/jimmunol.2200723

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Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A

Authors: Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Abankwa, Maja Köhn, Vesa P Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck

Journal: Nat Commun

PubMed ID: 36854761

Doi: 10.1038/s41467-023-36693-9

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Big data mining, rational modification, and ancestral sequence reconstruction inferred multiple xylose isomerases for biorefinery

Authors: Sitong Chen, Zhaoxian Xu, Boning Ding, Yuwei Zhang, Shuangmei Liu, Chenggu Cai, Muzi Li, Bruce E Dale, Mingjie Jin

Journal: Sci Adv

PubMed ID: 36724227

Doi: 10.1126/sciadv.add8835

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Network of hotspot interactions cluster tau amyloid folds

Authors: Vishruth Mullapudi, Jaime Vaquer-Alicea, Vaibhav Bommareddy, Anthony R Vega, Bryan D Ryder, Charles L White, Marc I Diamond, Lukasz A Joachimiak

Journal: Nat Commun

PubMed ID: 36797278

Doi: 10.1038/s41467-023-36572-3

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Engineered biocontainable RNA virus vectors for non-transgenic genome editing across crop species and genotypes

Authors: Qian Liu, Chenglu Zhao, Kai Sun, Yinlu Deng, Zhenghe Li

Journal: Mol Plant

PubMed ID: 36751129

Doi: 10.1016/j.molp.2023.02.003

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Efficient hydroxylation of flavonoids by using whole-cell P450 sca-2 biocatalyst in

Authors: Baodong Hu, Xinrui Zhao, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du

Journal: Front Bioeng Biotechnol

PubMed ID: 36873357

Doi: 10.3389/fbioe.2023.1138376

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Fused human paraoxonase 1 as a prophylactic agent against organophosphate poisoning

Authors: Prakashkumar Dobariya, Pratik Adhya, Bhupesh Vaidya, Prakash Y Khandave, Shyam Sunder Sharma, Abhay H Pande

Journal: Enzyme Microb Technol

PubMed ID: 36764031

Doi: 10.1016/j.enzmictec.2023.110209

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Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions

Authors: Arun Kumar Somavarapu, Giulia Kleijwegt, Madhu Nagaraj, Parvez Alam, Janni Nielsen, Daniel E Otzen

Journal: Chem Sci

PubMed ID: 36937574

Doi: 10.1039/d2sc05534a

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A rapid nucleic acid detection platform based on phosphorothioate-DNA and sulfur binding domain

Authors: Yuting Shuai, Yi Ju, Yuanhang Li, Dini Ma, Lan Jiang, Jingyu Zhang, Gao-Yi Tan, Xueting Liu, Shenlin Wang, Lixin Zhang, Guang Liu

Journal: Synth Syst Biotechnol

PubMed ID: 36875498

Doi: 10.1016/j.synbio.2023.02.002

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Cas12a-based one-pot SNP detection with high accuracy

Authors: Hong-Xia Zhang, Caixiang Zhang, Shuhan Lu, Xiaohan Tong, Kun Zhang, Hao Yin, Ying Zhang

Journal: Cell Insight

PubMed ID: 37193068

Doi: 10.1016/j.cellin.2023.100080

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Two pan-SARS-CoV-2 nanobodies and their multivalent derivatives effectively prevent Omicron infections in mice

Authors: Honghui Liu, Lili Wu, Bo Liu, Ke Xu, Wenwen Lei, Jianguo Deng, Xiaoyu Rong, Pei Du, Lebing Wang, Dongbin Wang, Xiaolong Zhang, Chao Su, Yuhai Bi, Hua Chen, William J Liu, Jianxun Qi, Qingwei Cui, Shuhui Qi, Ruiwen Fan, Jingkun Jiang, Guizhen Wu, George F Gao, Qihui Wang

Journal: cell reports. medicine

PubMed ID: 36702124

Doi: 10.1016/j.xcrm

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Siglec-9 Restrains Antibody-Dependent Natural Killer Cell Cytotoxicity against SARS-CoV-2

Authors: Pratima Saini, Opeyemi S Adeniji, Devivasha Bordoloi, Jennifer Kinslow, Jeff Martinson, Danielle M Parent, Kai Ying Hong, Jane Koshy, Abhijeet J Kulkarni, Netanel F Zilberstein, Robert A Balk, James N Moy, Leila B Giron, Russell P Tracy, Ali Keshavarzian, Kar Muthumani, Alan Landay, David B Weiner, Mohamed Abdel-Mohsen

Journal: MBio

PubMed ID: 36728420

Doi: 10.1128/mbio.03393-22

Products & Services: Proteins, Expression, Isolation and Analysis

Cathepsin H and cathepsin B of Cynoglossus semilaevis are involved in anti-bacterial immunity against Edwardsiella tarda

Authors: Yilong Wang, Hang Xu, Boguang Sun

Journal: Fish Shellfish Immunol

PubMed ID: 36754156

Doi: 10.1016/j.fsi.2023.108594

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular basis of RADAR anti-phage supramolecular assemblies

Authors: Yina Gao, Xiu Luo, Peipei Li, Zhaolong Li, Feng Ye, Songqing Liu, Pu Gao

Journal: Cell

PubMed ID: 36764292

Doi: 10.1016/j.cell.2023.01.026

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Insights into the oligomeric structure of the HIV-1 Vpu protein

Authors: Saman Majeed, Oluwatosin Adetuyi, Peter P Borbat, Md Majharul Islam, Olamide Ishola, Bo Zhao, Elka R Georgieva

Journal: J Struct Biol

PubMed ID: 36796461

Doi: 10.1016/j.jsb.2023.107943

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Engineered antibody cytokine chimera synergizes with DNA-launched nanoparticle vaccines to potentiate melanoma suppression

Authors: Nicholas J Tursi, Ziyang Xu, Michaela Helble, Susanne Walker, Kevin Liaw, Neethu Chokkalingam, Toshitha Kannan, Yuanhan Wu, Edgar Tello-Ruiz, Daniel H Park, Xizhou Zhu, Megan C Wise, Trevor R F Smith, Sonali Majumdar, Andrew Kossenkov, Daniel W Kulp, David B Weiner

Journal: Front Immunol

PubMed ID: 36911698

Doi: 10.3389/fimmu.2023.1072810

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Transcriptional dynamics of maize leaves, pollens and ovules to gain insights into heat stress-related responses

Authors: Ashok Babadev Jagtap, Inderjit Singh Yadav, Yogesh Vikal, Umesh Preethi Praba, Navneet Kaur, Adeshpal Singh Gill, Gurmukh S Johal

Journal: Front Plant Sci

PubMed ID: 36875566

Doi: 10.3389/fpls.2023.1117136

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A Balance between Pro-Inflammatory and Pro-Reparative Macrophages is Observed in Regenerative D-MAPS

Authors: Yining Liu, Alejandra Suarez-Arnedo, Shamitha Shetty, Yaoying Wu, Michelle Schneider, Joel H Collier, Tatiana Segura

Journal: Adv Sci (Weinh)

PubMed ID: 36762570

Doi: 10.1002/advs.202204882

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A novel role for trithorax in the gene regulatory network for a rapidly evolving fruit fly pigmentation trait

Authors: Michael L Weinstein, Chad M Jaenke, Hasiba Asma, Matthew Spangler, Katherine A Kohnen, Claire C Konys, Melissa E Williams, Ashley V Williams, Mark Rebeiz, Marc S Halfon, Thomas M Williams

Journal: PLoS Genet

PubMed ID: 36795790

Doi: 10.1371/journal.pgen.1010653

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Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu

Authors: Zeqian Xu, Xuanyu Qi, Minyue Bao, Tian Zhou, Junfeng Shi, Zhiyan Xu, Mingliang Zhou, Aldo R Boccaccini, Kai Zheng, Xinquan Jiang

Journal: Bioact Mater

PubMed ID: 36817824

Doi: 10.1016/j.bioactmat.2023.01.024

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Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T-cell lymphotrophic virus-1 (HTLV-1) Tax1 PBM

Authors: Airah Javorsky, Janesha C Maddumage, Emily R R Mackie, Tatiana P Soares da Costa, Patrick O Humbert, Marc Kvansakul

Journal: The FEBS journal

PubMed ID: 36029163

Doi: 10.1111/febs.16607

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Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination

Authors: Huasong Ai, Zebin Tong, Zhiheng Deng, Jiakun Tian, Liying Zhang, Maoshen Sun, Yunxiang Du, Ziyu Xu, Qiang Shi, Lujun Liang, Qingyun Zheng, Jia-Bin Li, Man Pan, and Lei Liu

Journal: Chem

Doi: 10.1016/j.chempr.2023.01.012

Products & Services: Gene Synthesis

Site-specific labeling of SBDS to monitor interactions with the 60S ribosomal subunit

Authors: Aparna Biswas, Yu-Fong Peng, Vikas Kaushik, Sofia Origanti

Journal: Methods

PubMed ID: 36781034

Doi: 10.1016/j.ymeth.2023.02.004

Products & Services: Proteins, Expression, Isolation and Analysis

The endogenous repertoire harbors self-reactive CD4 T cell clones that adopt a follicular helper T cell-like phenotype at steady state

Authors: Victoria Lee, Donald M Rodriguez, Nicole K Ganci, Sharon Zeng, Junting Ai, Jaime L Chao, Matthew T Walker, Christine H Miller, David E J Klawon, Mary H Schoenbach, Domenick E Kennedy, Mark Maienschein-Cline, Nicholas D Socci, Marcus R Clark, Peter A Savage

Journal: Nat Immunol

PubMed ID: 36759711

Doi: 10.1038/s41590-023-01425-0

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Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria

Authors: Aidan J Preston, Aaron Rogers, Miranda Sharp, Gareth Mitchell, Cristhian Toruno, Brayden B Barney, Lauren N Donovan, Journey Bly, Ryan Kennington, Emily Payne, Anthony Iovino, Gabriela Furukawa, Rosann Robinson, Bahar Shamloo, Matthew Buccilli, Rachel Anders, Sarah Eckstein, Elizabeth A Fedak, Tanner Wright, Carlo C Maley, Wendy K Kiso, Dennis Schmitt, David Malkin, Joshua D Schiffman, Lisa M Abegglen

Journal: Cell Death Discov

PubMed ID: 36797268

Doi: 10.1038/s41420-023-01348-7

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Soluble adenylyl cyclase coordinates intracellular pH homeostasis and biomineralization in calcifying cells of a marine animal

Authors: William Weijen Chang, Angus B Thies, Martin Tresguerres, Marian Y Hu

Journal: Am J Physiol Cell Physiol

PubMed ID: 36779665

Doi: 10.1152/ajpcell.00524.2022

Products & Services: Peptide Synthesis

Structure of metallochaperone in complex with the cobalamin-binding domain of its target mutase provides insight into cofactor delivery

Authors: Francesca A Vaccaro, David A Born, Catherine L Drennan

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36787360

Doi: 10.1073/pnas.2214085120

Products & Services: Insect Expression

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