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Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer

Authors: Giuditta Guerrini, Dora Mehn, Francesco Fumagalli, Sabrina Gioria, Mattia Pedotti, Luca Simonelli, Filippo Bianchini, Davide F Robbiani, Luca Varani, Luigi Calzolai

Journal: Int J Mol Sci

PubMed ID: 37834322

Doi: 10.3390/ijms241914875

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Binding mechanism and biological effects of flavone DYRK1A inhibitors for the design of new antidiabetics

Authors: Katarzyna Pustelny, Przemyslaw Grygier, Agata Barzowska, Barbara Pucelik, Alex Matsuda, Krzysztof Mrowiec, Emilia Slugocka, Grzegorz M Popowicz, Grzegorz Dubin, Anna Czarna

Journal: Sci Rep

PubMed ID: 37872245

Doi: 10.1038/s41598-023-44810-3

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Industry updates from the field of stem cell research and regenerative medicine in August 2023

Authors: Dusko Ilic, Mirjana Liovic

Journal: Regen Med

PubMed ID: 37786963

Doi: 10.2217/rme-2023-0181

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Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Authors: Payton A-B Weidenbacher, Mrinmoy Sanyal, Natalia Friedland, Shaogeng Tang, Prabhu S Arunachalam, Mengyun Hu, Ozan S Kumru, Mary Kate Morris, Jane Fontenot, Lisa Shirreff, Jonathan Do, Ya-Chen Cheng, Gayathri Vasudevan, Mark B Feinberg, Francois J Villinger, Carl Hanson, Sangeeta B Joshi, David B Volkin, Bali Pulendran, Peter S Kim

Journal: Nat Commun

PubMed ID: 37798288

Doi: 10.1038/s41467-023-42061-4

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LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric α-synuclein through NF-κB pathway

Authors: Kai-Jie He, Jin-Bao Zhang, Jun-Yi Liu, Feng-Lun Zhao, Xiao-Yu Yao, Yu-Ting Tang, Jin-Ru Zhang, Xiao-Yu Cheng, Li-Fang Hu, Fen Wang, Chun-Feng Liu

Journal: iScience

PubMed ID: 37876795

Doi: 10.1016/j.isci.2023.108130

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β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

Authors: Carole Daly, Akim Abdul Guseinov, Hyunggu Hahn, Adam Wright, Irina G Tikhonova, Alex Rojas Bie Thomsen, Bianca Plouffe

Journal: Elife

PubMed ID: 37855711

Doi: 10.7554/eLife.87754

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Development and characterization of a prototypic pan-amyloid clearing agent - a novel murine peptide-immunoglobulin fusion

Authors: James S Foster, Manasi Balachandran, Trevor J Hancock, Emily B Martin, Sallie Macy, Craig Wooliver, Tina Richey, Alan Stuckey, Angela D Williams, Joseph W Jackson, Stephen J Kennel, Jonathan S Wall

Journal: Front Immunol

PubMed ID: 37854603

Doi: 10.3389/fimmu.2023.1275372

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Whole-genome sequence and mass spectrometry study of the snow blight fungus Phacidium infestans (Karsten) DSM 5139 growing at freezing temperatures

Authors: C Zerouki, K Chakraborty, S Kuittinen, A Pappinen, O Turunen

Journal: Mol Genet Genomics

PubMed ID: 37815644

Doi: 10.1007/s00438-023-02073-7

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Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2

Authors: Rodrigo Lázaro-Gorines, Patricia Pérez, Ignacio Heras-Murillo, Irene Adán-Barrientos, Guillermo Albericio, David Astorgano, Sara Flores, Joanna Luczkowiak, Nuria Labiod, Seandean L Harwood, Alejandro Segura-Tudela, Laura Rubio-Pérez, Yudhi Nugraha, Xiaoran Shang, Yuxing Li, Carlos Alfonso, Kaylin A Adipietro, Dinendra L Abeyawardhane, Rocío Navarro, Marta Compte, Wenbo Yu, Alexander D MacKerell, Laura Sanz, David J Weber, Francisco J Blanco, Mariano Esteban, Edwin Pozharski, Raquel Godoy-Ruiz, Inés G Muñoz, Rafael Delgado, David Sancho, Juan García-Arriaza, Luis Álvarez-Vallina

Journal: Adv Sci (Weinh)

PubMed ID: 37863812

Doi: 10.1002/advs.202304818

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Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina

Authors: Heonuk Jeong, Deokho Lee, Xiaoyan Jiang, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara

Journal: Sci Rep

PubMed ID: 37857760

Doi: 10.1038/s41598-023-44983-x

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Selection, activity, and nuclease stabilization of cross-neutralizing DNA aptamers targeting HSV-1 and HSV-2

Authors: Michael D Schump, David I Bernstein, Fernando J Bravo, Charles P Neff

Journal: Virology

PubMed ID: 37925791

Doi: 10.1016/j.virol.2023.109916

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Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease

Authors: Takashi Kei Kishimoto, Max Fournier, Alicia Michaud, Gina Rizzo, Christopher Roy, Teresa Capela, Natasha Nukolova, Ning Li, Liam Doyle, Fen-Ni Fu, Derek VanDyke, Peter G Traber, Jamie B Spangler, Sheldon S Leung, Petr O Ilyinskii

Journal: J Autoimmun

PubMed ID: 37844543

Doi: 10.1016/j.jaut.2023.103125

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Aptabinding of tumor necrosis factor-α (TNFα) inhibits its proinflammatory effects and alleviates islet inflammation

Authors: Roaa Mahmoud, Jagan Kalivarathan, Abdul J Castillo, Sasha Wang, Brian Fuglestad, Mazhar A Kanak, Soma Dhakal

Journal: Biotechnol J

PubMed ID: 37772688

Doi: 10.1002/biot.202300374

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GhL1L1 regulates the contents of unsaturated fatty acids by activating the expression of GhFAD2 genes in cotton

Authors: Dandan Yue, Xuyang Hao, Bei Han, Jiao Xu, Weinan Sun, Xiaoping Guo, Xianlong Zhang, Xiyan Yang

Journal: Gene

PubMed ID: 37839764

Doi: 10.1016/j.gene.2023.147899

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A newly identified ferritin L-subunit variant results in increased proteasomal subunit degradation, impaired complex assembly, and severe hypoferritinemia

Authors: Dayana Shagidov, Noga Guttmann-Raviv, Séverine Cunat, Liora Frech, Muriel Giansily-Blaizot, Niraj Ghatpande, Gili Abelya, Gabriel A Frank, Patricia Aguilar Martinez, Esther G Meyron-Holtz

Journal: Am J Hematol

PubMed ID: 37867341

Doi: 10.1002/ajh.27124

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Characterization of a thermostable Cas12a ortholog

Authors: Jing Wu, Pan Gao, Yajing Shi, Caixiang Zhang, Xiaohan Tong, Huidi Fan, Xi Zhou, Ying Zhang, Hao Yin

Journal: Cell Insight

PubMed ID: 38047138

Doi: 10.1016/j.cellin.2023.100126

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A circRNA therapy based on Rnf103 to inhibit Vibrio anguillarum infection

Authors: Weiwei Zheng, Xing Lv, Yaqi Tao, Yanqiu Cui, Xiangxiang Zhu, Tongtong Zhu, Tianjun Xu

Journal: Cell Rep

PubMed ID: 37874674

Doi: 10.1016/j.celrep.2023.113314

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Genistein alleviates chronic heat stress-induced lipid metabolism disorder and mitochondrial energetic dysfunction by activating the GPR30-AMPK-PGC-1α signaling pathways in the livers of broiler chickens

Authors: Longlong Li, Ze Lu, Yulei Wang, Ying Yang, Huihui Wang, Haitian Ma

Journal: Poult Sci

PubMed ID: 37984004

Doi: 10.1016/j.psj.2023.103251

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Condensation of the N-terminal domain of human topoisomerase 1 is driven by electrostatic interactions and tuned by its charge distribution

Authors: Greta Bianchi, Marco Mangiagalli, Diletta Ami, Junaid Ahmed, Silvia Lombardi, Sonia Longhi, Antonino Natalello, Peter Tompa, Stefania Brocca

Journal: Int J Biol Macromol

PubMed ID: 38287572

Doi: 10.1016/j.ijbiomac.2023.127754

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Molecular insights into the HLA-B35 molecules' classification associated with HIV control

Authors: Christian A Lobos, Demetra Sm Chatzileontiadou, Bonin Sok, Coral-Ann Almedia, Hanim Halim, Lloyd D'Orsogna, Stephanie Gras

Journal: Immunol Cell Biol

PubMed ID: 37811811

Doi: 10.1111/imcb.12698

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Intervention of AXL in EGFR Signaling via Phosphorylation and Stabilization of MIG6 in Non-Small Cell Lung Cancer

Authors: Ya-Yu Yang, Sheng-Chieh Lin, Jong-Ding Lay, Chun-Yu Cho, Te-Hsuan Jang, Hsiu-Ying Ku, Chih-Jung Yao, Shuang-En Chuang

Journal: Int J Mol Sci

PubMed ID: 37834326

Doi: 10.3390/ijms241914879

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Unfolding of an RNA G-quadruplex motif in the negative strand genome of porcine reproductive and respiratory syndrome virus by host and viral helicases to promote viral replication

Authors: Puxian Fang, Congbao Xie, Ting Pan, Ting Cheng, Wei Chen, Sijin Xia, Tong Ding, Junkang Fang, Yanrong Zhou, Liurong Fang, Dengguo Wei, Shaobo Xiao

Journal: Nucleic Acids Res

PubMed ID: 37739415

Doi: 10.1093/nar/gkad759

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Histone Abundance Quantification via Flow Cytometry of Htb2-GFP Allows Easy Monitoring of Cell Cycle Perturbations in Living Yeast Cells, Comparable to Standard DNA Staining

Authors: Maria V Kulakova, Eslam S M O Ghazy, Fedor Ryabov, Yaroslav M Stanishevskiy, Michael O Agaphonov, Alexander I Alexandrov

Journal: J Fungi (Basel)

PubMed ID: 37888289

Doi: 10.3390/jof9101033

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The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection

Authors: Déborah Lécuyer, Roberta Nardacci, Désirée Tannous, Emie Gutierrez-Mateyron, Aurélia Deva Nathan, Frédéric Subra, Cristina Di Primio, Paola Quaranta, Vanessa Petit, Clémence Richetta, Ali Mostefa-Kara, Franca Del Nonno, Laura Falasca, Romain Marlin, Pauline Maisonnasse, Julia Delahousse, Juliette Pascaud, Eric Deprez, Marie Naigeon, Nathalie Chaput, Angelo Paci, Véronique Saada, David Ghez, Xavier Mariette, Mario Costa, Mauro Pistello, Awatef Allouch, Olivier Delelis, Mauro Piacentini, Roger Le Grand, Jean-Luc Perfettini

Journal: Front Immunol

PubMed ID: 37920468

Doi: 10.3389/fimmu.2023.1270081

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A spacer design strategy for CRISPR-Cas12f1 with single-nucleotide polymorphism mutation resolution capability and its application in the mutations diagnosis of pathogens

Authors: Panqi Gao, Maoyi Yang, Yi Chen, Jun Yan, Miaomiao Han, Haijun Deng, Keli Qian, Jiandong Yang, Yaoqin Lu, Ling Zhou, Ailong Huang, Xiaosong Li, Wanyan Deng, Quanxin Long

Journal: J Med Virol

PubMed ID: 37855689

Doi: 10.1002/jmv.29189

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A novel recombinant S-based subunit vaccine induces protective immunity against porcine deltacoronavirus challenge in piglets

Authors: Jizong Li, Shuqing Zhao, Baotai Zhang, Jin Huang, Qi Peng, Li Xiao, Xuesong Yuan, Rongli Guo, Jinzhu Zhou, Baochao Fan, Tao Xue, Xuejiao Zhu, Chuanmin Liu, Xing Zhu, Lili Ren, Bin Li

Journal: J Virol

PubMed ID: 37846983

Doi: 10.1128/jvi.00958-23

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Structure-function relationships in ShKT domain peptides: ShKT-Ts1 from the sea anemone Telmatactis stephensoni

Authors: Karoline Sanches, Lauren M Ashwood, Abisola Ave-Maria Olushola-Siedoks, Dorothy C C Wai, Arfatur Rahman, Kashmala Shakeel, Muhammad Umair Naseem, Gyorgy Panyi, Peter J Prentis, Raymond S Norton

Journal: Proteins

PubMed ID: 37794633

Doi: 10.1002/prot.26594

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Cell-Permeable Stimuli-Responsive Ubiquitin Probe for Time- Resolved Monitoring of Substrate Ubiquitination in Live Cells

Authors: Lu-Jun Liang, Yu Wang, Xiao Hua, Rujing Yuan, Qiong Xia, Rongtian Wang, Chuntong Li, Guo-Chao Chu, Lei Liu, and Yi-Ming Li

Journal: JACS Au

Doi: 10.1021/jacsau.3c00421

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A thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering

Authors: Zhiheng Yang , Zilong Li , Bixiao Li , Ruihong Bu , Gao-Yi Tan , Zhengduo Wang , Hao Yan , Zhenguo Xin , Guojian Zhang , Ming Li , Hua Xiang, Lixin Zhang , Weishan Wang

Journal: Nat Commun .

PubMed ID: 37794017

Doi: 10.1038/s41467-023-41973-5

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A 3D-printed blood-brain barrier model with tunable topology and cell-matrix interactions

Authors: Louis S Paone , Mohammed Mehdi Benmassaoud , Aidan Curran , Sebastián L Vega , Peter A Galie

Journal: Biofabrication .

PubMed ID: 37820611

Doi: 10.1088/1758-5090/ad0260

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Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes

Authors: Madeeha Ghazi, Shivangi Khanna, Yogaspoorthi Subramaniam, Jeyashri Rengaraju, Farina Sultan, Iti Gupta, Kanupriya Sharma, Sudhir Chandna, Rajesh S Gokhale, Vivek T Natarajan

Journal: Nucleic Acids Res

PubMed ID: 37697436

Doi: 10.1093/nar/gkad704

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A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation

Authors: Lounis Yakhou, Anaelle Azogui, Nikhil Gupta, Julien Richard Albert, Fumihito Miura, Laure Ferry, Kosuke Yamaguchi, Sarah Battault, Pierre Therizols, Frédéric Bonhomme, Elouan Bethuel, Arpita Sarkar, Maxim V C Greenberg, Paola B Arimondo, Gael Cristofari, Olivier Kirsh, Takashi Ito, Pierre-Antoine Defossez

Journal: Nucleic Acids Res

PubMed ID: 37650637

Doi: 10.1093/nar/gkad719

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Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells

Authors: Mihir B Doshi, Namgyu Lee, Tenzin Tseyang, Olga Ponomarova, Hira Lal Goel, Meghan Spears, Rui Li, Lihua Julie Zhu, Christopher Ashwood, Karl Simin, Cholsoon Jang, Arthur M Mercurio, Albertha J M Walhout, Jessica B Spinelli, Dohoon Kim

Journal: Nature

PubMed ID: 37880368

Doi: 10.1038/s41586-023-06676-3

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A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells

Authors: Xinlin Liu, Linli Luan, Xi Liu, Dingwen Jiang, Junwen Deng, Jiazhen Xu, Yang Yuan, Jiyao Xing, Bingguan Chen, Dongming Xing, Haiming Huang

Journal: Front Immunol

PubMed ID: 37954614

Doi: 10.3389/fimmu.2023.1292839

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Dual immunization with CdtB protein and flagellin epitope offers augmented protection against enteric fever in mice

Authors: Shania Vij, Reena Thakur, Raghwendra Pratap Singh, Rashmi Kumar, Preeti Pathania, Varsha Gupta, Chander Raman Suri, Praveen Rishi

Journal: Life Sci

PubMed ID: 37918629

Doi: 10.1016/j.lfs.2023.122216

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Therapeutic effect of exosomes derived from hepatocyte-growth-factor-overexpressing adipose mesenchymal stem cells on liver injury

Authors: Liushenyan Yu, Junchao Xue, Yanyan Wu, Hanyu Zhou

Journal: Folia Histochem Cytobiol

PubMed ID: 37787035

Doi: 10.5603/fhc.95291

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Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients

Authors: Christa Lichtensteiger, Maximilian Koblischke, Fiamma Berner, Ann-Kristin Jochum, Tobias Sinnberg, Beatrice Balciunaite, Mette-Triin Purde, Vincent Walter, Marie-Therese Abdou, Kathrin Hofmeister, Philipp Kohler, Pietro Vernazza, Werner C Albrich, Christian R Kahlert, Alexander Zoufaly, Marianna T Traugott, Lukas Kern, Urs Pietsch, Gian-Reto Kleger, Miodrag Filipovic, Manfred Kneilling, Antonio Cozzio, Oltin Pop, David Bomze, Andreas Bergthaler, Omar Hasan Ali, Judith Aberle, Lukas Flatz

Journal: J Autoimmun

PubMed ID: 37826919

Doi: 10.1016/j.jaut.2023.103118

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A Polyvalent Adhesin-Toxoid Multiepitope-Fusion-Antigen-Induced Functional Antibodies against Five Enterotoxigenic Adhesins (CS7, CS12, CS14, CS17, and CS21) but Not Enterotoxins (LT and STa)

Authors: Siqi Li, Hyesuk Seo, Ipshita Upadhyay, Weiping Zhang

Journal: Microorganisms

PubMed ID: 37894131

Doi: 10.3390/microorganisms11102473

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Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19

Authors: Gang Ye, Ruangang Pan, Fan Bu, Jian Zheng, Alise Mendoza, Wei Wen, Lanying Du, Benjamin Spiller, Brian E Wadzinski, Bin Liu, Stanley Perlman, Fang Li

Journal: J Virol

PubMed ID: 37855638

Doi: 10.1128/jvi.01448-23

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Varying the expression pattern of the strigolactone receptor gene results in phenotypes distinct from both wild type and knockout mutants

Authors: Revel S M Drummond, Hui Wen Lee, Zhiwei Luo, Jack F Dakin, Bart J Janssen, Kimberley C Snowden

Journal: Front Plant Sci

PubMed ID: 37900765

Doi: 10.3389/fpls.2023.1277617

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Improved prime editing allows for routine predictable gene editing in Physcomitrium patens

Authors: Pierre-François Perroud, Anouchka Guyon-Debast, Josep M Casacuberta, Wyatt Paul, Jean-Philippe Pichon, David Comeau, Fabien Nogué

Journal: J Exp Bot

PubMed ID: 37243510

Doi: 10.1093/jxb/erad189

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Structural and dynamical changes of the Streptococcus gordonii metalloregulatory ScaR protein induced by Mn ion binding

Authors: Katarina Radman, Zoe Jelić Matošević, Dijana Žilić, Ivo Crnolatac, Nikola Bregović, Marina Kveder, Ivo Piantanida, Pedro A Fernandes, Ivana Leščić Ašler, Branimir Bertoša

Journal: Int J Biol Macromol

PubMed ID: 37866578

Doi: 10.1016/j.ijbiomac.2023.127572

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The Functional Characteristics and Soluble Expression of Saffron CCD2

Authors: Ying Wang, Siqi Li, Ze Zhou, Lifen Sun, Jing Sun, Chuanpu Shen, Ranran Gao, Jingyuan Song, Xiangdong Pu

Journal: Int J Mol Sci

PubMed ID: 37894770

Doi: 10.3390/ijms242015090

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Electroacupuncture at GB20 improves cognitive ability and synaptic plasticity via the CaM-CaMKII-CREB signaling pathway following cerebral ischemia-reperfusion injury in rats

Authors: Qing Han, Feng Wang

Journal: Acupunct Med

PubMed ID: 38126262

Doi: 10.1177/09645284231202805

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Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization

Authors: Rajesh P Ringe, Philippe Colin, Gabriel Ozorowski, Joel D Allen, Anila Yasmeen, Gemma E Seabright, Jeong Hyun Lee, Aleksandar Antanasijevic, Kimmo Rantalainen, Thomas Ketas, John P Moore, Andrew B Ward, Max Crispin, P J Klasse

Journal: PLoS Pathog

PubMed ID: 37903160

Doi: 10.1371/journal.ppat.1011601

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VP2 residue N142 of coxsackievirus A10 is critical for the interaction with KREMEN1 receptor and neutralizing antibodies and the pathogenicity in mice

Authors: Xue Li, Zeyu Liu, Xingyu Yan, Yuan Tian, Kexin Liu, Yue Zhao, Jiang Shao, Pei Hao, Chao Zhang

Journal: PLoS Pathog

PubMed ID: 37788227

Doi: 10.1371/journal.ppat.1011662

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One ring closer to a closure: the crystal structure of the ES hydroxymethylbilane synthase intermediate

Authors: Helene J Bustad, Marthe S Christie, Mikko Laitaoja, Aasne K Aarsand, Aurora Martinez, Janne Jänis, Juha P Kallio

Journal: FEBS J

PubMed ID: 37863644

Doi: 10.1111/febs.16982

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Diversity of rhodopsin cyclases in zoospore-forming fungi

Authors: Matthias Broser, Wayne Busse, Anika Spreen, Maila Reh, Yinth Andrea Bernal Sierra, Songhwan Hwang, Tillmann Utesch, Han Sun, Peter Hegemann

Journal: Proc Natl Acad Sci U S A

PubMed ID: 37871207

Doi: 10.1073/pnas.2310600120

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Vγ9+Vδ2+ T cell control of Listeria monocytogenes growth in infected epithelial cells requires butyrophilin 3A genes

Authors: Katrin Fischer, Michaela Bradlerova, Thomas Decker, Verena Supper

Journal: Sci Rep

PubMed ID: 37903831

Doi: 10.1038/s41598-023-45587-1

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New twists of a TAIL: novel insights into the histone binding properties of a highly conserved PHD finger cluster within the MLR family of H3K4 mono-methyltransferases

Authors: Claudia B Zraly, Richard Schultz, Manuel O Diaz, Andrew K Dingwall

Journal: Nucleic Acids Res

PubMed ID: 37638761

Doi: 10.1093/nar/gkad698

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Construction and functional verification of size-reduced plasmids based on TMP resistance gene

Authors: Chun-Cao Li, Rui Hu, Xiu-Min Hua, Yi-Xuan Ni, Lu Ge, Lu Zhang, Wen Yu, Ni-Xin Hao, Hui Xia, Qiang Fang, Zhi-Yong Tao

Journal: Microbiol Spectr

PubMed ID: 37905802

Doi: 10.1128/spectrum.01206-23

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STT3A-mediated viral N-glycosylation underlies the tumor selectivity of oncolytic virus M1

Authors: Deli Song, Xudong Jia, Yuanzhu Gao, Tong Xiao, Jia Dan, Runling Shen, Jing Cai, Jiankai Liang, Wenbo Zhu, Jun Hu, Guangmei Yan, Qinfen Zhang, Yuan Lin

Journal: Oncogene

PubMed ID: 37864032

Doi: 10.1038/s41388-023-02872-7

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Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis

Authors: Alžběta Motyčková, Luboš Voleman, Vladimíra Najdrová, Lenka Arbonová, Martin Benda, Vít Dohnálek, Natalia Janowicz, Ronald Malych, Róbert Šuťák, Thijs J G Ettema, Staffan Svärd, Courtney W Stairs, Pavel Doležal

Journal: PLoS Pathog

PubMed ID: 37792908

Doi: 10.1371/journal.ppat.1010773

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Acrylamide induces neurotoxicity in zebrafish (Danio rerio) via NLRP3-mediated pyroptosis

Authors: Boya Zhang, Mengyao Zhao, Xiaoguo Ji, Quanming Xia, Lihua Jiang, Liming Zhao

Journal: Science of The Total Environment

PubMed ID: 37392875

Doi: 10.1016/j.scitotenv.2023.165208

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miR-19b-3p regulated by estrogen controls lipid synthesis through targeting MSMO1 and ELOVL5 in LMH cells

Authors: Qihui Jia, Yuzhu Cao, Mengmeng Zhang, Yuxin Xing, Tian Xia, Yulong Guo, Yaxin Yue, Xin Li, Xiaojun Liu, Yanhua Zhang, Donghua Li, Zhuanjian Li, Yadong Tian, Xiangtao Kang, Hong Li

Journal: Poult Sci

PubMed ID: 37939591

Doi: 10.1016/j.psj.2023.103200

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Profibrogenic macrophage-targeted delivery of mitochondrial protector via exosome formula for alleviating pulmonary fibrosis

Authors: Wei Zhang, Zhuo Wan, Di Qu, Wenqi Sun, Liang Zhang, Yuan Liang, Lei Pan, Hua Jiang, Zichen Ye, Mengying Wei, Lijun Yuan, Guodong Yang, Faguang Jin

Journal: Bioact Mater

PubMed ID: 37965241

Doi: 10.1016/j.bioactmat.2023.09.019

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Inherited myogenic abilities in muscle precursor cells defined by the mitochondrial complex I-encoding protein

Authors: Norio Motohashi, Katsura Minegishi, Yoshitsugu Aoki

Journal: Cell Death Dis

PubMed ID: 37857600

Doi: 10.1038/s41419-023-06192-2

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Allosterically inhibited PFKL via prostaglandin E2 withholds glucose metabolism and ovarian cancer invasiveness

Authors: Shengmiao Chen, Yiran Wu, Yang Gao, Chenxu Wu, Yuetong Wang, Chun Hou, Miao Ren, Shuyuan Zhang, Qi Zhu, Jiali Zhang, Yufeng Yao, Mei Huang, Yingchuan B Qi, Xue-Song Liu, Tiffany Horng, Haopeng Wang, Dan Ye, Zhengjiang Zhu, Suwen Zhao, Gaofeng Fan

Journal: Cell Rep

PubMed ID: 37831605

Doi: 10.1016/j.celrep.2023.113246

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Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma

Authors: Yunyun Chen, Kun Zhang, Rui Zhang, Zhuo Wang, Liang Yang, Tingting Zhao, Shihui Zhang, Yong Lin, Hongzhou Zhao, Yongpan Liu, Yuxuan Wei, Yijian Zhou, Jiaying Zhang, Xianzong Ye, Jing Zhao, Xinxin Li, Jianwen Que, Songlin Shi, Kuancan Liu

Journal: Cell Death Discov

PubMed ID: 37891174

Doi: 10.1038/s41420-023-01693-7

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Replenishing decoy extracellular vesicles inhibits phenotype remodeling of tissue-resident cells in inflammation-driven arthritis

Authors: Mengmeng Liang, Ke Wang, Xiaoyu Wei, Xiaoshan Gong, Hao Tang, Hao Xue, Jing Wang, Pengbin Yin, Licheng Zhang, Zaisong Ma, Ce Dou, Shiwu Dong, Jianzhong Xu, Fei Luo, Qinyu Ma

Journal: Cell Rep Med

PubMed ID: 37852176

Doi: 10.1016/j.xcrm.2023.101228

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Ubiquitin-specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity

Authors: Sigrun K Maurer, Matthias P Mayer, Stephanie J Ward, Sana Boudjema, Mohamed Halawa, Jiatong Zhang, Simon G Caulton, Jonas Emsley, Ingrid Dreveny

Journal: J Biol Chem

PubMed ID: 37777157

Doi: 10.1016/j.jbc.2023.105300

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LMNB1 targets FOXD1 to promote progression of prostate cancer

Authors: Yuanshe Huang, Lai Zhang, Tianlei Liu, E Liang

Journal: Exp Ther Med

PubMed ID: 37840569

Doi: 10.3892/etm.2023.12212

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Inhibitory effect of Eimeria maxima IFN-γ inhibitory molecules on the immune function of T cell subsets in chickens

Authors: Xianglin Pu, Yangdong Pan, Quanjia Xiang, Mingmin Lu, Lixin Xu, Ruofeng Yan, Xiangrui Li, Xiaokai Song

Journal: Poult Sci

PubMed ID: 37797491

Doi: 10.1016/j.psj.2023.103098

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ActuAtor, a Listeria-inspired molecular tool for physical manipulation of intracellular organizations through de novo actin polymerization

Authors: Hideki Nakamura, Elmer Rho, Christopher T Lee, Kie Itoh, Daqi Deng, Satoshi Watanabe, Shiva Razavi, Hideaki T Matsubayashi, Cuncheng Zhu, Eleanor Jung, Padmini Rangamani, Shigeki Watanabe, Takanari Inoue

Journal: Cell Rep

PubMed ID: 37734382

Doi: 10.1016/j.celrep.2023.113089

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Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking

Authors: Lihong Liu, Ryan G Casner, Yicheng Guo, Qian Wang, Sho Iketani, Jasper Fuk-Woo Chan, Jian Yu, Bernadeta Dadonaite, Manoj S Nair, Hiroshi Mohri, Eswar R Reddem, Shuofeng Yuan, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kwok-Yung Yuen, Zizhang Sheng, Yaoxing Huang, Jesse D Bloom, Lawrence Shapiro, David D Ho

Journal: Immunity

PubMed ID: 37776849

Doi: 10.1016/j.immuni.2023.09.003

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Next step in the development of mesoprogestins: the preclinical profile of EC313

Authors: K Błaszczak-Świątkiewicz, A Krupa, E Mnich, W Elger, M Oettel, H Nair, M Wierzbicki, P Sieroszewski, Z Shaked

Journal: Front Endocrinol (Lausanne)

PubMed ID: 37766684

Doi: 10.3389/fendo.2023.1201547

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The MprF homolog LysX synthesizes lysyl-diacylglycerol contributing to antibiotic resistance and virulence

Authors: Cameron P Gill, Christopher Phan, Vivien Platt, Danielle Worrell, Thomas Andl, Hervé Roy

Journal: Microbiol Spectr

PubMed ID: 37768052

Doi: 10.1128/spectrum.01429-23

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Single-Dose Intranasal Immunisation with Novel Chimeric H1N1 Expressing the Receptor-Binding Domain of SARS-CoV-2 Induces Robust Mucosal Immunity, Tissue-Resident Memory T Cells, and Heterologous Protection in Mice

Authors: Donghong Wang, Yao Deng, Jianfang Zhou, Wen Wang, Baoying Huang, Wenling Wang, Lan Wei, Jiao Ren, Ruiwen Han, Jialuo Bing, Chengcheng Zhai, Xiaoyan Guo, Wenjie Tan

Journal: Vaccines (Basel)

PubMed ID: 37766130

Doi: 10.3390/vaccines11091453

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A conserved N protein nano-vaccine of COVID-19 exerts potent and cross-reactive humoral and cellular immune responses in mice

Authors: Bing Li, Jing Zhang, Yang Huang, Xinrui Li, Jing Feng, Yan Li, Rongxin Zhang

Journal: J Med Virol

PubMed ID: 37750245

Doi: 10.1002/jmv.29115

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Clinical Course, Immunogenicity, and Efficacy of BNT162b2 mRNA Vaccination Against SARS-CoV-2 Infection in Liver Transplant Recipients

Authors: Eunice X Tan, Wen Hui Lim, Elizabeth Thong, Jean-Marc Chavatte, Jinyan Zhang, Jonathan Lim, Jocelyn Y Jin, Daniel R X Lim, Jaclyn Y T Kang, Ansel Shao Pin Tang, Kai En Chan, Caitlyn Tan, Shi Ni Tan, Benjamin Nah, Daniel Q Huang, Lin-Fa Wang, Paul A Tambyah, Jyoti Somani, Barnaby Young, Mark D Muthiah

Journal: Transplant Direct

PubMed ID: 37745946

Doi: 10.1097/TXD.0000000000001537

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Camel nanobody-based B7-H3 CAR-T cells show high efficacy against large solid tumours

Authors: Dan Li, Ruixue Wang, Tianyuzhou Liang, Hua Ren, Chaelee Park, Chin-Hsien Tai, Weiming Ni, Jing Zhou, Sean Mackay, Elijah Edmondson, Javed Khan, Brad St Croix, Mitchell Ho

Journal: Nat Commun

PubMed ID: 37739951

Doi: 10.1038/s41467-023-41631-w

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Studying temporal titre evolution of commercial SARS-CoV-2 assays reveals significant shortcomings of using BAU standardization for comparison

Authors: Inge Kroidl, Simon Winter, Raquel Rubio-Acero, Abhishek Bakuli, Christof Geldmacher, Tabea M Eser, Flora Déak, Sacha Horn, Anna Zielke, Mohamed I M Ahmed, Paulina Diepers, Jessica Guggenbühl, Jonathan Frese, Jan Bruger, Kerstin Puchinger, Jakob Reich, Philine Falk, Alisa Markgraf, Heike Fensterseifer, Ivana Paunovic, Angelika Thomschke, Michael Pritsch, Friedrich Riess, Elmar Saathoff, Michael Hoelscher, Laura Olbrich, Noemi Castelletti, Andreas Wieser

Journal: Virol J

PubMed ID: 37658454

Doi: 10.1186/s12985-023-02167-z

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Ameliorative effect of Alangium chinense (Lour) Harms on rheumatoid arthritis by reducing autophagy with targeting regulate JAK3-STAT3 and COX-2 pathways

Authors: Ting Xiao, Xingyan Cheng, Yuan Zhi, Fangfang Tian, Ai Wu, Feilong Huang, Ling Tao, Zhenghong Guo, Xiangchun Shen

Journal: J Ethnopharmacol

PubMed ID: 37690476

Doi: 10.1016/j.jep.2023.117133

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Differentiating the roles of Mycobacterium tuberculosis substrate binding proteins, FecB and FecB2, in iron uptake

Authors: Rodger de Miranda, Bonnie J Cuthbert, Thaís Klevorn, Alex Chao, Jessica Mendoza, Mark Arbing, Paul J Sieminski, Kadamba Papavinasasundaram, Sumer Abdul-Hafiz, Sum Chan, Christopher M Sassetti, Sabine Ehrt, Celia W Goulding

Journal: PLoS Pathog

PubMed ID: 37747938

Doi: 10.1371/journal.ppat.1011650

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Listeria-based vaccination against the pericyte antigen RGS5 elicits anti-vascular effects and colon cancer protection

Authors: Trevor S Anderson, Amanda L McCormick, Elizabeth A Daugherity, Mariam Oladejo, Izuchukwu F Okpalanwaka, Savanna L Smith, Duke Appiah, Laurence M Wood, Devin B Lowe

Journal: Oncoimmunology

PubMed ID: 37781234

Doi: 10.1080/2162402X.2023.2260620

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Lactiplantibacillus plantarum as a novel platform for production and purification of integral membrane proteins using RseP as the benchmark

Authors: Sofie S Kristensen, Marie V Lukassen, Suzana Siebenhaar, Dzung B Diep, J Preben Morth, Geir Mathiesen

Journal: Sci Rep

PubMed ID: 37658186

Doi: 10.1038/s41598-023-41559-7

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Engineering gain-of-function mutants of a WW domain by dynamics and structural analysis

Authors: Jin Lu, Mohammad Imtiazur Rahman, I Can Kazan, Nicholas R Halloran, Andrey A Bobkov, S Banu Ozkan, Giovanna Ghirlanda

Journal: Protein Sci

PubMed ID: 37574787

Doi: 10.1002/pro.4759

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Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity

Authors: Huangcan Li, Xiong Wang, Yiran Wang, Yichen Li, Ying Chen, Yin-Ting Wong, Jufang He, Ming-Liang He

Journal: Signal Transduct Target Ther

PubMed ID: 37743411

Doi: 10.1038/s41392-023-01630-1

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Characterization of nanodisc-forming peptides for membrane protein studies

Authors: Bankala Krishnarjuna, Gaurav Sharma, Sang-Choul Im, Richard Auchus, G M Anantharamaiah, Ayyalusamy Ramamoorthy

Journal: J Colloid Interface Sci

PubMed ID: 37801850

Doi: 10.1016/j.jcis.2023.09.162

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Intracellular Fusobacterium nucleatum infection attenuates antitumor immunity in esophageal squamous cell carcinoma

Authors: Yiqiu Li, Shan Xing, Fangfang Chen, Qifan Li, Shuheng Dou, Yuying Huang, Jun An, Wanli Liu, Ge Zhang

Journal: Nat Commun

PubMed ID: 37723150

Doi: 10.1038/s41467-023-40987-3

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Ionocyte-Specific Regulation of Cystic Fibrosis Transmembrane Conductance Regulator

Authors: Yukiko Sato, Dusik Kim, Mark J Turner, Yishan Luo, Syeda Sadaf Zehra Zaidi, David Y Thomas, John W Hanrahan

Journal: Am J Respir Cell Mol Biol

PubMed ID: 36952679

Doi: 10.1165/rcmb.2022-0241OC

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Ligand-displaying cells and minicells for programmable delivery of toxic payloads via type IV secretion systems

Authors: Yang Grace Li, Kouhei Kishida, Natsumi Ogawa-Kishida, Peter J Christie

Journal: MBio

PubMed ID: 37772866

Doi: 10.1128/mbio.02143-23

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Quantitative assessment of near-infrared fluorescent proteins

Authors: Hanbin Zhang, Stavrini Papadaki, Xiaoting Sun, Xinyue Wang, Mikhail Drobizhev, Luxia Yao, Michel Rehbock, Reinhard W Köster, Lianfeng Wu, Kazuhiko Namikawa, Kiryl D Piatkevich

Journal: Nat Methods

PubMed ID: 37666982

Doi: 10.1038/s41592-023-01975-z

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Intracellular K limits T cell exhaustion and preserves antitumor function

Authors: Camille Collier, Kelly Wucherer, Matthew McWhorter, Chelsea Jenkins, Alexandra Bartlett, Rahul Roychoudhuri, Robert Eil

Journal: biorxiv

PubMed ID: 37745435

Doi: 10.1101/2023.09.13.556997

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ROS-scavenging anti-inflammatory nucleic acid delivery system for targeted treatment of atherosclerosis

Authors: Zunjing Liua , Zihao Liub , Yi Shanc , Chen Xub , Bingran Yub, FuJian Xub

Journal: Nano Today

Doi: 10.1016/j.nantod.2023.102005

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An artificially split class 3 intein

Authors: Tia M Ariagno , John S Smetana , Christopher W Lennon

Journal: MicroPubl Biol .

PubMed ID: 37811346

Doi: 10.17912/micropub.biology.000977

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Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion

Authors: Junwei Gao , Can Cao , Mingfei Shi , Shihao Hong , Shijie Guo , Jing Li , Tengxiao Liang , Ping Song , Ruodan Xu , Ning Li

Journal: Phytomedicine .

PubMed ID: 37421767

Doi: 10.1016/j.phymed.2023.154942

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Epitope editing enables targeted immunotherapy of acute myeloid leukaemia

Authors: Gabriele Casirati, Andrea Cosentino, Adele Mucci, Mohammed Salah Mahmoud, Iratxe Ugarte Zabala, Jing Zeng, Scott B Ficarro, Denise Klatt, Christian Brendel, Alessandro Rambaldi, Jerome Ritz , Jarrod A Marto, Danilo Pellin, Daniel E Bauer, Scott A Armstrong, Pietro Genovese

Journal: Nature

PubMed ID: 37648862

Doi: 10.1038/s41586-023-06496-5

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Antibody response in patients undergoing chronic hemodialysis post-severe acute respiratory syndrome coronavirus 2 vaccination: A prospective observational study

Authors: Heejung Choi, Sungdam Han, Ji Su Kim, Bumhee Park, Min-Jeong Lee, Gyu-Tae Shin, Heungsoo Kim, Kyongmin Kim, A-Young Park, Ho-Joon Shin, Inwhee Park

Journal: Medicine (Baltimore)

PubMed ID: 37773791

Doi: 10.1097/MD.0000000000035484

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PluriBAC: A Versatile Baculovirus-Based Modular System to Express Heterologous Genes in Different Biotechnological Platforms

Authors: Leslie C Amorós Morales, Abril Marchesini, Santiago M Gómez Bergna, Matías García Fallit, Silvana E Tongiani, Larisa Vásquez, María Leticia Ferrelli, Guillermo A Videla-Richardson, Marianela Candolfi, Víctor Romanowski, Matías L Pidre

Journal: Viruses

PubMed ID: 37896762

Doi: 10.3390/v15101984

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An autonomous activation of interleukin-17 receptor signaling sustains inflammation and promotes disease progression

Authors: Qiong Luo , Yijun Liu , Ke Shi , Xuecheng Shen , Yaqi Yang , Xuejiao Liang , Liangliang Lu , Wenxuan Qiao , Airu Chen , Dongmei Hong , Yang Sun , Qiang Xu

Journal: Immunity

PubMed ID: 37473759

Doi: 10.1016/j.immuni.2023.06.012

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Development of an anti-SARS-CoV-2 monoclonal antibody panel and its applicability as a reagent in high-throughput fluorescence reduction neutralization and immunohistochemistry assays

Authors: Gabriela M Coelho, Allan H D Cataneo, Sonia M Raboni, Meri B Nogueira, Caroline B Vaz de Paula, Ana C S F Almeida, Vanessa Z Rogerio, Nilson T Zanchin, Lucia de Noronha, Camila Zanluca, Claudia N Duarte Dos Santos

Journal: J Med Virol

PubMed ID: 37750235

Doi: 10.1002/jmv.29111

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Immuno-bioinformatic approach for designing of multi-epitope merozoite surface antigen of Babesia bigemina and evaluation of its immunogenicity in inoculated calves

Authors: Z Ul Rehman, M Suleman, K Ashraf, S Ali, S Rahman, M I Rashid

Journal: Pol J Vet Sci

PubMed ID: 37727102

Doi: 10.24425/pjvs.2023.145047

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Unambiguous discrimination of all 20 proteinogenic amino acids and their modifications by nanopore

Authors: Kefan Wang, Shanyu Zhang, Xiao Zhou, Xian Yang, Xinyue Li, Yuqin Wang, Pingping Fan, Yunqi Xiao, Wen Sun, Panke Zhang, Wenfei Li, Shuo Huang

Journal: Nat Methods

PubMed ID: 37749214

Doi: 10.1038/s41592-023-02021-8

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Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer's disease-related mouse models

Authors: Debashis Dutta, Malabendu Jana, Ramesh Kumar Paidi, Moumita Majumder, Sumita Raha, Sridevi Dasarathy, Kalipada Pahan

Journal: J Clin Invest

PubMed ID: 37552543

Doi: 10.1172/JCI161987

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A mechanism that ensures non-selective cytoplasm degradation by autophagy

Authors: Tetsuya Kotani, Yuji Sakai, Hiromi Kirisako, Chika Kakuta, Soichiro Kakuta, Yoshinori Ohsumi, Hitoshi Nakatogawa

Journal: Nat Commun

PubMed ID: 37726301

Doi: 10.1038/s41467-023-41525-x

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A computationally designed antigen eliciting broad humoral responses against SARS-CoV-2 and related sarbecoviruses

Authors: Sneha Vishwanath, George William Carnell, Matteo Ferrari, Benedikt Asbach, Martina Billmeier, Charlotte George, Maria Suau Sans, Angalee Nadesalingam, Chloe Qingzhou Huang, Minna Paloniemi, Hazel Stewart, Andrew Chan, David Arthur Wells, Patrick Neckermann, David Peterhoff, Sebastian Einhauser, Diego Cantoni, Martin Mayora Neto, Ingo Jordan, Volker Sandig, Paul Tonks, Nigel Temperton, Simon Frost, Katharina Sohr, Maria Teresa Lluesma Ballesteros, Farzad Arbabi, Johannes Geiger, Christian Dohmen, Christian Plank, Rebecca Kinsley, Ralf Wagner, Jonathan Luke Heeney

Journal: Nat Biomed Eng

PubMed ID: 37749309

Doi: 10.1038/s41551-023-01094-2

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A Humanized Yeast System for Evaluating the Protein Prenylation of a Wide Range of Human and Viral CaaX Sequences

Authors: Emily R Hildebrandt, Anushka Sarkar, Rajani Ravishankar, June H Kim, Walter K Schmidt

Journal: biorxiv

PubMed ID: 37786692

Doi: 10.1101/2023.09.19.558494

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Driving forces behind phase separation of the carboxy-terminal domain of RNA polymerase II

Authors: David Flores-Solis, Irina P Lushpinskaia, Anton A Polyansky, Arya Changiarath, Marc Boehning, Milana Mirkovic, James Walshe, Lisa M Pietrek, Patrick Cramer, Lukas S Stelzl, Bojan Zagrovic, Markus Zweckstetter

Journal: Nat Commun

PubMed ID: 37749095

Doi: 10.1038/s41467-023-41633-8

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A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo

Authors: Burcu Bestas, Sandra Wimberger, Dmitrii Degtev, Alexandra Madsen, Antje K Rottner, Fredrik Karlsson, Sergey Naumenko, Megan Callahan, Julia Liz Touza, Margherita Francescatto, Carl Ivar Möller, Lukas Badertscher, Songyuan Li, Silvia Cerboni, Niklas Selfjord, Elke Ericson, Euan Gordon, Mike Firth, Krzysztof Chylinski, Amir Taheri-Ghahfarokhi, Mohammad Bohlooly-Y, Mike Snowden, Menelaos Pangalos, Barrett Nuttall, Pinar Akcakaya, Grzegorz Sienski, Marcello Maresca

Journal: Nat Commun

PubMed ID: 37673883

Doi: 10.1038/s41467-023-41240-7

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