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An efficient transformation method for genome editing of elite bread wheat cultivars

Authors: Akshaya K Biswal, L Ruben B Hernandez, Ana I R Castillo, Juan M Debernardi, Kanwarpal S Dhugga

Journal: Front Plant Sci

PubMed ID: 37275249

Doi: 10.3389/fpls.2023.1135047

Products & Services: Custom DNA/RNA Oligos

L-Lactate treatment by photosynthetic cyanobacteria expressing heterogeneous L-lactate dehydrogenase

Authors: Yuichi Kato, Kosuke Inabe, Yuji Haraguchi, Tatsuya Shimizu, Akihiko Kondo, Tomohisa Hasunuma

Journal: Sci Rep

PubMed ID: 37142758

Doi: 10.1038/s41598-023-34289-3

Products & Services: Gene Synthesis

A rapidly evolving single copy histone H1 variant is associated with male fertility in a parasitoid wasp

Authors: Bo Yuan, Yi Yang, Zhichao Yan, Chun He, Yu H Sun, Fei Wang, Beibei Wang, Jiamin Shi, Shan Xiao, Fang Wang, Qi Fang, Fei Li, Xinhai Ye, Gongyin Ye

Journal: Front Cell Dev Biol

PubMed ID: 37325562

Doi: 10.3389/fcell.2023.1166517

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Identification of a Transmembrane Protein Involved in Shear Stress Signaling and Hepatocarcinogenesis After a Sustained Virological Response to Hepatitis C Virus

Authors: Masashi Nishikawa, Hikari Okada, Kazunori Kawaguchi, Tetsuro Shimakami, Kouki Nio, Kuniaki Arai, Tatsuya Yamashita, Motoko Sasaki, Shuichi Kaneko, Taro Yamashita, Masao Honda

Journal: Cell Mol Gastroenterol Hepatol

PubMed ID: 37146715

Doi: 10.1016/j.jcmgh.2023.04.006

Products & Services: Proteins, Expression, Isolation and Analysis

Modular Hydrogel Vaccine for Programmable and Coordinate Elicitation of Cancer Immunotherapy

Authors: Panpan Ji, Wenqi Sun, Siyan Zhang, Yuqi Xing, Chen Wang, Mengying Wei, Qiuyun Li, Gang Ji, Guodong Yang

Journal: Adv Sci (Weinh)

PubMed ID: 37222047

Doi: 10.1002/advs.202301789

Products & Services: Proteins, Expression, Isolation and Analysis

The free-living flagellate Paratrimastix pyriformis uses a distinct mitochondrial carrier to balance adenine nucleotide pools

Authors: Justyna Zítek, Martin S King, Priscila Peña-Diaz, Eva Pyrihová, Alannah C King, Edmund R S Kunji, Vladimír Hampl

Journal: Arch Biochem Biophys

PubMed ID: 37192692

Doi: 10.1016/j.abb.2023.109638

Products & Services: Proteins, Expression, Isolation and Analysis

The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms

Authors: Duy Lan Huong Bui, Andrew Roach, Jingxian Li, Sumit J Bandekar, Elizabeth Orput, Ritika Raghavan, Demet Araç, Richard C Sando

Journal: Cell Rep

PubMed ID: 37224017

Doi: 10.1016/j.celrep.2023.112552

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Antimicrobial activity of the Flo peptide produced in Scenedesmus acutus and Nannochloropsis oculata

Authors: Saraí Damaris Dávalos-Guzmán, Fidel Martinez-Gutierrez, Luzmila Martínez-González, Jesús Josafath Quezada-Rivera, Ana Cecilia Lorenzo-Leal, Horacio Bach, José Francisco Morales-Domínguez, Ruth Elena Soria-Guerra

Journal: World J Microbiol Biotechnol

PubMed ID: 37249711

Doi: 10.1007/s11274-023-03664-7

Products & Services: Gene Synthesis

Circ_0069094 regulates malignant phenotype and paclitaxel resistance in breast cancer cells via targeting the miR-136-5p/YWHAZ axis

Authors: Zhihua Kong, Qi Han, Bisheng Zhu, Long Wan, Enrong Feng

Journal: Thorac Cancer

PubMed ID: 37192740

Doi: 10.1111/1759-7714.14928

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Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing

Authors: Christopher C Pan, Raquel Maeso-Díaz, Tylor R Lewis, Kun Xiang, Lianmei Tan, Yaosi Liang, Liuyang Wang, Fengrui Yang, Tao Yin, Calvin Wang, Kuo Du, De Huang, Seh Hoon Oh, Ergang Wang, Bryan Jian Wei Lim, Mengyang Chong, Peter B Alexander, Xuebiao Yao, Vadim Y Arshavsky, Qi-Jing Li, Anna Mae Diehl, Xiao-Fan Wang

Journal: Cell Res

PubMed ID: 37169907

Doi: 10.1038/s41422-023-00820-4

Products & Services: PCR Cloning and Subcloning

Improved biosynthesis of heme in Bacillus subtilis through metabolic engineering assisted fed-batch fermentation

Authors: Shaomei Yang, Anlong Wang, Jiachang Li, Yunhang Shao, Fengjie Sun, Shucheng Li, Kai Cao, Hongliang Liu, Peng Xiong, Zhengquan Gao

Journal: Microb Cell Fact

PubMed ID: 37198628

Doi: 10.1186/s12934-023-02077-3

Products & Services: Gene Synthesis

Transcriptome Analysis and Identification of Sesquiterpene Synthases in Liverwort Jungermannia exsertifolia

Authors: Xiaoguang Yan, Yukun Li, Weiguo Li, Dongmei Liang, Shengxin Nie, Ruiqi Chen, Jianjun Qiao, Mingzhang Wen, Qinggele Caiyin

Journal: Bioengineering (Basel) .

PubMed ID: 37237639

Doi: 10.3390/bioengineering10050569

Products & Services: Proteins, Expression, Isolation and Analysis

Reprogramming methanol utilization pathways to convert Saccharomyces cerevisiae to a synthetic methylotroph

Authors: Chunjun Zhan, Xiaowei Li, Guangxu Lan, Edward E. K. Baidoo, Yankun Yang, Yuzhong Liu, Yang Sun, Shijie Wang, Yanyan Wang, Guokun Wang, Jens Nielsen, Jay D. Keasling, Yun Chen & Zhonghu Bai

Journal: Nature Catalysis

Doi: doi.org/10.1038/s41929-023-00957-w

Products & Services: Codon Optimization

Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes

Authors: Jonathan D Teo , Oana C Marian , Alanna G Spiteri , Madeline Nicholson , Huitong Song , Jasmine X Y Khor , Holly P McEwen , Anjie Ge , Monokesh K Sen , Laura Piccio , Jessica L Fletcher , Nicholas J C King , Simon S Murray , Jens C Brüning , Anthony S Don

Journal: Glia .

PubMed ID: 36583573

Doi: 10.1002/glia.24329

Products & Services: Recombinant Proteins

A molecular study on recombinant pullulanase type I from Metabacillus indicus.

Authors: Zahraa Z Al-Mamoori , Amira M Embaby , Ahmed Hussein , Hoda E Mahmoud

Journal: AMB Express

PubMed ID: 37119334

Doi: 10.1186/s13568-023-01545-8.

Products & Services: Gene Synthesis

Adjuvant-Free COVID-19 Vaccine with Glycoprotein Antigen Oxidized by Periodate Rapidly Elicits Potent Immune Responses

Authors: Ru-Yan Zhang, Shi-Hao Zhou, Ran-Ran Feng, Yu Wen, Dong Ding, Zhi-Ming Zhang, Hua-Wei Wei, Jun Guo

Journal: ACS Chemical Biology

PubMed ID: 37009726

Doi: 10.1021/acschembio.3c00050

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LvCD14L Acts as a Novel Pattern Recognition Receptor and a Regulator of the Toll Signaling Pathway in Shrimp

Authors: Xinjia Lv, Shihao Li 1,2,3, Yang Yu, Songjun Jin, Xiaojun Zhang, Fuhua Li

Journal: International Journal of Molecular Sciences

Doi: 10.3390/ijms24097770

Products & Services: Proteins, Expression, Isolation and Analysis eBlot™ L1 Fast Wet Transfer System

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

Authors: Dongchun Ni, Priscilla Turelli, Bertrand Beckert, Sergey Nazarov, Emiko Uchikawa, Alexander Myasnikov, Florence Pojer, Didier Trono, Henning Stahlberg, Kelvin Lau

Journal: PLoS pathogens

PubMed ID: 37018380

Doi: 10.1371/journal.ppat.1011206

Products & Services: Gene Synthesis

Knockdown of the salivary protein gene NlG14 caused displacement of the lateral oviduct secreted components and inhibited ovulation in Nilaparvata lugens

Authors: Haoli Gao, Huihui Zhang, Xiaowei Yuan, Xumin Lin, Jianzheng Zou, Na Yu, Zewen Liu

Journal: PLOS Genetics

PubMed ID: 37011098

Doi: 10.1371/journal.pgen.1010704

Products & Services: Proteins, Expression, Isolation and Analysis

Precise integration of large DNA sequences in plant genomes using PrimeRoot editors

Authors: Chao Sun, Yuan Lei, Boshu Li, Qiang Gao, Yunjia Li, Wen Cao, Chao Yang, Hongchao Li, Zhiwei Wang, Yan Li, Yanpeng Wang, Jun Liu, Kevin Tianmeng Zhao, Caixia Gao

Journal: Nature Biotechnology

PubMed ID: 37095350

Doi: 10.1038/s41587-023-01769-w

Products & Services: Gene Synthesis

Protein Delivery to Insect Epithelial Cells In Vivo: Potential Application to Functional Molecular Analysis of Proteins in Butterfly Wing Development

Authors: Yugo Nakazato, Joji M Otaki

Journal: BioTech (Basel)

PubMed ID: 37092472

Doi: 10.3390/biotech12020028

Products & Services: Molecular Biology Reagents

Is Penguin Circovirus Circulating Only in the Antarctic Circle? Lack of Viral Detection in Namibia

Authors: Laura C Roberts, Umberto Molini, Lauren M Coetzee, Siegfried Khaiseb, Jean-Paul Roux, Jessica Kemper, David G Roberts, Katrin Ludynia, Marcus Doherr, Darrell Abernethy, Giovanni Franzo

Journal: Animals (Basel)

PubMed ID: 37174486

Doi: 10.3390/ani13091449

Products & Services: Molecular Biology Reagents

Novel targeting assay uncovers targeting information within peroxisomal ABC transporter Pxa1

Authors: Renate L M Jansen, Marco van den Noort, Arjen M Krikken, Chen Bibi, Astrid Böhm, Maya Schuldiner, Einat Zalckvar, Ida J van der Klei

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 37028652

Doi: 10.1016/j.bbamcr.2023.119471

Products & Services: Plasmid DNA Preparation

A novel anti-membrane CD30 single-chain variable fragment discovered from the human phage library: A potential targeted immunotherapy

Authors: Thanida Chanpong, Watee Seesuay, Wararat Chiangjong, Piamsiri Jiramornimit, Sarinthip Preedagasamzin, Korakot Atjanasuppat, Bunyada Jittorntrum, Somsak Prasongtanakij, Supannikar Tawinwung, Sulada Pukiat, Chonticha Saisawang, Suparerk Borwornpinyo, Khanit Sa-Ngiamsuntorn, Wanpen Chaichumpa, Suradej Hongeng, Usanarat Anurathapan

Journal: PLoS ONE

PubMed ID: 37079526

Doi: 10.1371/journal.pone.0284708

Products & Services: Codon Optimization

FTO promotes cervical cancer cell proliferation, colony formation, migration and invasion via the regulation of the BMP4/Hippo/YAP1/TAZ pathway

Authors: Jinyuan Huang, Jing Yang, Yudi Zhang, Dan Lu, Yinmei Dai

Journal: Exp Cell Res

PubMed ID: 37030332

Doi: 10.1016/j.yexcr.2023.113585

Products & Services: Proteins, Expression, Isolation and Analysis

Chemical shift assignments of calmodulin bound to a cytosolic domain of GluN2A (residues 1004-1024) from the NMDA receptor

Authors: Aritra Bej, James B Ames

Journal: Biomol NMR Assign

PubMed ID: 37029330

Doi: 10.1007/s12104-023-10125-7

Products & Services: Peptide Synthesis

Constitutively activated AMPKα1 protects against skeletal aging in mice by promoting bone-derived IGF-1 secretion

Authors: Yiqi Yang, Kai Yuan, Yihao Liu, Qishan Wang, Yixuan Lin, Shengbing Yang, Kai Huang, Tianyou Kan, Yuxin Zhang, Mingming Xu, Zhifeng Yu, Qiming Fan, Yugang Wang, Hanjun Li, Tingting Tang

Journal: Cell Prolif

PubMed ID: 37042047

Doi: 10.1111/cpr.13476

Products & Services: Proteins, Expression, Isolation and Analysis

ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience

Authors: Natalia Jiménez-Moreno, Madhu Kollareddy, Petros Stathakos, Joanna J Moss, Zuriñe Antón, Deborah K Shoemark, Richard B Sessions, Ralph Witzgall, Maeve Caldwell, Jon D Lane

Journal: J Cell Biol

PubMed ID: 37014324

Doi: 10.1083/jcb.201910133

Products & Services: Molecular Biology Reagents

Tuning the immune response: sulfated archaeal glycolipid archaeosomes as an effective vaccine adjuvant for induction of humoral and cell-mediated immunity towards the SARS-CoV-2 Omicron variant of concern

Authors: Tyler M Renner, Bassel Akache, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates, Lise Deschatelets, Renu Dudani, Blair A Harrison, Jason Baardsnes, Izel Koyuturk, Jennifer J Hill, Usha D Hemraz, Sophie Régnier, Anne E G Lenferink, Yves Durocher, Michael J McCluskie

Journal: Frontiers in Immunology

PubMed ID: 37122746

Doi: 10.3389/fimmu.2023.1182556

Products & Services: Recombinant Proteins Gene Synthesis

Baseline corticosterone levels in spadefoot toads reflect alternate larval diets one year later

Authors: Cristina C Ledón-Rettig, Katie M Lo, Sarah R Lagon

Journal: Gen Comp Endocrinol

PubMed ID: 37094616

Doi: 10.1016/j.ygcen.2023.114291

Products & Services: Proteins, Expression, Isolation and Analysis

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism

Authors: Ashley Haluck-Kangas, Madelaine Fink, Elizabeth T Bartom, Marcus E Peter

Journal: Mol Biomed

PubMed ID: 37059938

Doi: 10.1186/s43556-023-00119-1

Products & Services: Proteins, Expression, Isolation and Analysis

Single particle cryo-EM analysis of Rickettsia conorii Sca2 reveals a formin-like core

Authors: Peter J Carman, Grzegorz Rebowski, Roberto Dominguez, Saif S Alqassim

Journal: J Struct Biol

PubMed ID: 37028467

Doi: 10.1016/j.jsb.2023.107960

Products & Services: Proteins, Expression, Isolation and Analysis

High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo

Authors: Sebastian G Huayamares, Melissa P Lokugamage, Regina Rab, Alejandro J Da Silva Sanchez, Hyejin Kim, Afsane Radmand, David Loughrey, Liming Lian, Yuning Hou, Bhagelu R Achyut, Annette Ehrhardt, Jeong S Hong, Cory D Sago, Kalina Paunovska, Elisa Schrader Echeverri, Daryll Vanover, Philip J Santangelo, Eric J Sorscher, James E Dahlman

Journal: J Control Release

PubMed ID: 37028451

Doi: 10.1016/j.jconrel.2023.04.005

Products & Services: Proteins, Expression, Isolation and Analysis

Production of Clubroot Standards Using a Recombinant Surrogate to Overcome Natural Genetic Variability

Authors: Anjana Patel, Roy Kennedy

Journal: Plants (Basel)

PubMed ID: 37111913

Doi: 10.3390/plants12081690

Products & Services: Proteins, Expression, Isolation and Analysis

Shieldin complex assembly kinetics and DNA binding by SHLD3

Authors: Vivek Susvirkar, Alex C Faesen

Journal: Commun Biol

PubMed ID: 37031298

Doi: 10.1038/s42003-023-04757-7

Products & Services: Peptide Synthesis

Development and evaluation of an indirect ELISA using a multiepitope antigen for the diagnosis of intestinal schistosomiasis

Authors: Karine Ferreira Lopes, Mariana Lourenço Freire, Dayane Costa Souza Lima, Martin Johannes Enk, Edward Oliveira, Stefan Michael Geiger

Journal: Parasitology

PubMed ID: 37092694

Doi: 10.1017/S0031182023000409

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Mycobacterium tuberculosis-Specific CD4 T Cells Expressing Transcription Factors T-Bet or RORγT Associate with Bacterial Control in Granulomas

Authors: Nicole L Grant, Kristen Kelly, Pauline Maiello, Helena Abbott, Shelby O'Connor, Philana Ling Lin, Charles A Scanga, JoAnne L Flynn

Journal: MBio

PubMed ID: 37039646

Doi: 10.1128/mbio.00477-23

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Interspecies/Intergroup Complementation of Orthotospovirus Replication and Movement through Reverse Genetics Systems

Authors: Mingfeng Feng, Minglong Chen, Yulong Yuan, Qinhai Liu, Ruixiang Cheng, Tongqing Yang, Luyao Li, Rong Guo, Yongxin Dong, Jing Chen, Yawen Yang, Yuling Yan, Hongmin Cui, Dong Jing, Jinrui Kang, Shuxian Chen, Jia Li, Min Zhu, Changjun Huang, Zhongkai Zhang, Richard Kormelink, Xiaorong Tao

Journal: J Virol

PubMed ID: 37022194

Doi: 10.1128/jvi.01809-22

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Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway

Authors: Alexander D Fulford, Leonie Enderle, Jannette Rusch, Didier Hodzic, Maxine V Holder, Alex Earl, Robin Hyunseo Oh, Nicolas Tapon, Helen McNeill

Journal: J Cell Biol

PubMed ID: 37071483

Doi: 10.1083/jcb.202204059

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Proteomic analysis of extracellular vesicles from tick hemolymph and uptake of extracellular vesicles by salivary glands and ovary cells

Authors: Zhengmao Xu, Yanan Wang, Meng Sun, Yongzhi Zhou, Jie Cao, Houshuang Zhang, Xuenan Xuan, Jinlin Zhou

Journal: Parasit Vectors

PubMed ID: 37046327

Doi: 10.1186/s13071-023-05753-w

Products & Services: Recombinant Proteins

Low-grade glioma risk SNP rs11706832 is associated with type I interferon response pathway genes in cell lines

Authors: Adam Rosenbaum, Anna M Dahlin, Ulrika Andersson, Benny Björkblom, Wendy Yi-Ying Wu, Håkan Hedman, Carl Wibom, Beatrice Melin

Journal: Sci Rep

PubMed ID: 37185361

Doi: 10.1038/s41598-023-33923-4

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Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases

Authors: Iris D Zelnik, Beatriz Mestre, Jonathan J Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel J Fleishman, Anthony H Futerman

Journal: Nat Commun

PubMed ID: 37087500

Doi: 10.1038/s41467-023-38047-x

Products & Services: Proteins, Expression, Isolation and Analysis

A Recombinant Chimeric Cedar Virus-Based Surrogate Neutralization Assay Platform for Pathogenic Henipaviruses

Authors: Moushimi Amaya, Randy Yin, Lianying Yan, Viktoriya Borisevich, Bishwo N Adhikari, Andrew Bennett, Francisco Malagon, Regina Z Cer, Kimberly A Bishop-Lilly, Antony S Dimitrov, Robert W Cross, Thomas W Geisbert, Christopher C Broder

Journal: Viruses

PubMed ID: 37243163

Doi: 10.3390/v15051077

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A triple amplification strategy using GR-5 DNAzyme as a signal medium for ultrasensitive detection of trace Pb based on CRISPR/Cas12a empowered electrochemical biosensor

Authors: Yuanyuan Yue, Songtao Wang, Qiang Jin, Nan An, Lina Wu, He Huang

Journal: Anal Chim Acta

PubMed ID: 37225346

Doi: 10.1016/j.aca.2023.341241

Products & Services: Proteins, Expression, Isolation and Analysis

Modulatory role of copper on hIAPP aggregation and toxicity in presence of insulin

Authors: Dipanwita Roy, Narayan Chandra Maity, Sourav Kumar, Anupam Maity, Bhisma N Ratha, Ranjit Biswas, Nakul Chandra Maiti, Atin Kumar Mandal, Anirban Bhunia

Journal: Int J Biol Macromol

PubMed ID: 37088193

Doi: 10.1016/j.ijbiomac.2023.124470

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Endoplasmic reticulum chaperone GRP78 participates in fluoride-induced autophagy in LS8 cells by regulating the IRE1-TRAF2-JNK pathway

Authors: Lin Zhao, Liyuan Wang, Han Wang, Tao Xi, Sijia Liu, Yang Li, Jianping Ruan, Yongqing Huang

Journal: Environ Toxicol

PubMed ID: 37070943

Doi: 10.1002/tox.23805

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Structural basis of impaired disaggregase function in the oxidation-sensitive SKD3 mutant causing 3-methylglutaconic aciduria

Authors: Sukyeong Lee, Sang Bum Lee, Nuri Sung, Wendy W Xu, Changsoo Chang, Hyun-Eui Kim, Andre Catic, Francis T F Tsai

Journal: Nat Commun

PubMed ID: 37041140

Doi: 10.1038/s41467-023-37657-9

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Immunological characterization of a VIR protein family member (VIR-14) in Plasmodium vivax-infected subjects from different epidemiological regions in Africa and South America

Authors: Raianna F Fantin, Camila H Coelho, Anne D Berhe, Luisa M D Magalhães, Dhélio B Pereira, Nichole D Salinas, Niraj H Tolia, Chanaki Amaratunga, Seila Suon, Issaka Sagara, David L Narum, Ricardo T Fujiwara, Claudia Abejon, Antonio Campos-Neto, Patrick E Duffy, Lilian L Bueno

Journal: PLoS Negl Trop Dis

PubMed ID: 37027391

Doi: 10.1371/journal.pntd.0011229

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Interaction of LARP4 to filamin A mechanosensing domain regulates cell migrations

Authors: Zhenfeng Mao, Fumihiko Nakamura

Journal: Front Cell Dev Biol

PubMed ID: 37169020

Doi: 10.3389/fcell.2023.1152109

Products & Services: Proteins, Expression, Isolation and Analysis

Organization, genomic targeting, and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis

Authors: Wei Fu, Yaoguang Yu, Jie Shu , Zewang Yu, Yixiong Zhong, Tao Zhu, Zhihao Zhang, Zhenwei Liang, Yuhai Cui, Chen Chen , Chenlong Li

Journal: Plant Cell .

PubMed ID: 37062961

Doi: 10.1093/plcell/koad111

Products & Services: Proteins, Expression, Isolation and Analysis

Codon pair bias deoptimization of essential genes in infectious laryngotracheitis virus reduces protein expression

Authors: Paola K Vaz, Marzieh Armat, Carol A Hartley, Joanne M Devlin

Journal: J Gen Virol

PubMed ID: 37010948

Doi: 10.1099/jgv.0.001836

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COVID-19 adenovirus vector vaccine induces higher interferon and pro-inflammatory responses than mRNA vaccines in human PBMCs, macrophages and moDCs

Authors: Miao Jiang, Elina Väisänen, Pekka Kolehmainen, Moona Huttunen, Seppo Ylä-Herttuala, Seppo Meri, Pamela Österlund, Ilkka Julkunen

Journal: Vaccine

PubMed ID: 37142461

Doi: 10.1016/j.vaccine.2023.04.049

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Clinical Validation of a Colorimetric Loop-Mediated Isothermal Amplification Using a Portable Device for the Rapid Detection of SARS-CoV-2

Authors: Bruna W Raddatz, Felipe J Rabello, Rafael Benedetti, Gisleine J Steil, Louise M Imamura, Edson Y S Kim, Erika B Santiago, Luís F Hartmann, João V Predebon, Bruna M Delfino, Meri B Nogueira, Jucélia S Dos Santos, Breno G da Silva, Diego R P Nicollete, Bernardo M M de Almeida, Sergio R Rogal, Marcus V M Figueredo

Journal: Diagnostics (Basel)

PubMed ID: 37046573

Doi: 10.3390/diagnostics13071355

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Sub-millisecond conformational dynamics of the A adenosine receptor revealed by single-molecule FRET

Authors: Ivan Maslov, Oleksandr Volkov, Polina Khorn, Philipp Orekhov, Anastasiia Gusach, Pavel Kuzmichev, Andrey Gerasimov, Aleksandra Luginina, Quinten Coucke, Andrey Bogorodskiy, Valentin Gordeliy, Simon Wanninger, Anders Barth, Alexey Mishin, Johan Hofkens, Vadim Cherezov, Thomas Gensch, Jelle Hendrix, Valentin Borshchevskiy

Journal: Commun Biol

PubMed ID: 37012383

Doi: 10.1038/s42003-023-04727-z

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Modular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responses

Authors: Audrey Kassardjian, Eric Sun, Jamie Sookhoo, Krithika Muthuraman, Kayluz Frias Boligan, Iga Kucharska, Edurne Rujas, Arif Jetha, Donald R Branch, Shawn Babiuk, Brian Barber, Jean-Philippe Julien

Journal: Cell Rep

PubMed ID: 37053069

Doi: 10.1016/j.celrep.2023.112391

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SLFN5-mediated chromatin dynamics sculpt higherorder DNA repair topology

Authors: Jinzhou Huang, Chenming Wu, Jake A Kloeber, Huanyao Gao, Ming Gao, Qian Zhu, Yiming Chang, Fei Zhao, Guijie Guo, Kuntian Luo, Haiming Dai, Sijia Liu, Qiru Huang, Wootae Kim, Qin Zhou, Shouhai Zhu, Zheming Wu, Xinyi Tu, Ping Yin, Min Deng, Liewei Wang, Jian Yuan, Zhenkun Lou

Journal: molecular cell

PubMed ID: 36854302

Doi: 10.1016/j.molcel.2023.02.004

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Multifunctional activity-based chemical probes for sirtuins

Authors: Chiranjeev Sharma, Dickson Donu, Alyson M Curry, Elizabeth Barton, Yana Cen

Journal: RSC Adv

PubMed ID: 37063743

Doi: 10.1039/d3ra02133e

Products & Services: Proteins, Expression, Isolation and Analysis

Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization

Authors: Mallika Sastry, Anita Changela, Jason Gorman, Kai Xu, Gwo-Yu Chuang, Chen-Hsiang Shen, Cheng Cheng, Hui Geng, Sijy O'Dell, Li Ou, Reda Rawi, Mateo Reveiz, Guillaume B E Stewart-Jones, Shuishu Wang, Baoshan Zhang, Tongqing Zhou, Andrea Biju, Michael Chambers, Xuejun Chen, Angela R Corrigan, Bob C Lin, Mark K Louder, Krisha McKee, Alexandra F Nazzari, Adam S Olia, Danealle K Parchment, Edward K Sarfo, Tyler Stephens, Jonathan Stuckey, Yaroslav Tsybovsky, Raffaello Verardi, Yiran Wang, Cheng-Yan Zheng, Yuling Chen, Nicole A Doria-Rose, Adrian B McDermott, John R Mascola, Peter D Kwong

Journal: J Virol

PubMed ID: 37098956

Doi: 10.1128/jvi.01604-22

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H, N, C backbone and Cβ resonance assignments for UBQLN1 UBA and UBAA domains

Authors: Gwen R Buel, Xiang Chen, Olumide Kayode, Anthony Cruz, Kylie J Walters

Journal: Biomol NMR Assign

PubMed ID: 37022617

Doi: 10.1007/s12104-023-10127-5

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Enhanced Degradation of Mutant -Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and Neuroprotection

Authors: Allison S Vanecek, Jelena Mojsilovic-Petrovic, Robert G Kalb, Jetze J Tepe

Journal: ACS Chem Neurosci

PubMed ID: 37015082

Doi: 10.1021/acschemneuro.2c00732

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Salt stress-induced chloroplastic hydrogen peroxide stimulates pdTPI sulfenylation and methylglyoxal accumulation

Authors: Zheng-Wei Fu, Yu-Rui Feng, Xiang Gao, Feng Ding, Jian-Hui Li, Ting-Ting Yuan, Ying-Tang Lu

Journal: Plant Cell

PubMed ID: 36695476

Doi: 10.1093/plcell/koad019

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Direct Virus Gene Detection: A CRISPR/dCas9-Mediated Surface- Enhanced Raman Scattering Strategy with Enzyme-Catalyzed Signal Amplification

Authors: Ailing Su , Yuan Liu , Xiumian Cao , Junyi Zhao , Weiqing Xu , Chongyang Liang , Ping Li , Shuping Xu

Journal: Anal Chem .

PubMed ID: 36995921

Doi: 10.1021/acs.analchem.2c05384

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Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults

Authors: Chanchan Xiao, Zhiyao Ren , Bei Zhang , Lipeng Mao , Guodong Zhu , Lijuan Gao , Jun Su , Jiezhou Ye , Ze Long , Yue Zhu , Pengfei Chen , Xiangmeng Su , Tong Zhou , Yanhao Huang , Xiongfei Chen , Chaojun Xie , Jun Yuan , Yutian Hu , Jingshan Zheng , Zhigang Wang , Jianrong Lou , Xiang Yang , Zhiqiang Kuang , Hongyi Zhang , Pengcheng Wang , Xiaofeng Liang , Oscar Junhong Luo , Guobing Chen

Journal: Nat Aging .

PubMed ID: 37117789

Doi: 10.1038/s43587-023-00379-0

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Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling

Authors: Ikuo Masuho , Nickolas K Skamangas , Brian S Muntean , Kirill A Martemyanov

Journal: Cell Syst .

PubMed ID: 33667409

Doi: 10.1016/j.cels.2021.02.001

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Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking

Authors: Dongxue Wang, Yunjin Yao, Shiqi Wang, Yifei Hou, Lanxue Zhao, Hao Wang, Hongzhuan Chen, Jianrong Xu

Journal: Int J Mol Sci

PubMed ID: 37108518

Doi: 10.3390/ijms24087356

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Melittin derived peptide-drug conjugate, M-DM1, inhibits tumor progression and induces effector cell infiltration in melanoma by targeting M2 tumor-associated macrophages

Authors: Chanmi Jeong, Jeongdong Kim, Ik-Hwan Han, Soyoung Kim, Ilseob Choi, Hongsung Kim, Jin-Hyun Jeong, Hyunsu Bae

Journal: Front Immunol

PubMed ID: 37122692

Doi: 10.3389/fimmu.2023.1178776

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A Ferritin Nanoparticle-Based Zika Virus Vaccine Candidate Induces Robust Humoral and Cellular Immune Responses and Protects Mice from Lethal Virus Challenge

Authors: Aryamav Pattnaik, Bikash R Sahoo, Lucas R Struble, Gloria E O Borgstahl, You Zhou, Rodrigo Franco, Raul G Barletta, Fernando A Osorio, Thomas M Petro, Asit K Pattnaik

Journal: Vaccines (Basel)

PubMed ID: 37112733

Doi: 10.3390/vaccines11040821

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8-Methoxyflindersine-Induced Apoptosis and Cell Cycle Disorder Involving MAPK Signaling Activation in Human Colorectal Cancer Cells

Authors: Dianbao Zhang, Yunmei Fu, Ying Liu, Yifan Wu, Jiayu Chen, Luting Zhang, Rui Wang, Zaixing Chen, Tao Liu

Journal: Int J Mol Sci

PubMed ID: 37175741

Doi: 10.3390/ijms24098039

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Porcine Deltacoronavirus-like Particles Produced by a Single Recombinant Baculovirus Elicit Virus-Specific Immune Responses in Mice

Authors: Yangkun Liu, Xueying Han, Yaqi Qiao, Tiejun Wang, Lunguang Yao

Journal: Viruses

PubMed ID: 37243181

Doi: 10.3390/v15051095

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Mellitin peptide quantification in seasonally collected crude bee venom and its anticancer effects on myelogenous K562 human leukaemia cell line

Authors: Maher Obeidat, Ihab F Al-Khraisat, Da'san M M Jaradat, Bayan Y Ghanim, Qasem M Abdallah, Duaa Abu Arqoub, Duaa Sabbah, Ola M Al-Sanabra, Tawfiq Arafat, Nidal A Qinna

Journal: BMC Complement Med Ther

PubMed ID: 37098530

Doi: 10.1186/s12906-023-03897-x

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Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils

Authors: Einav Tayeb-Fligelman, Jeannette T Bowler, Christen E Tai, Michael R Sawaya, Yi Xiao Jiang, Gustavo Garcia, Sarah L Griner, Xinyi Cheng, Lukasz Salwinski, Liisa Lutter, Paul M Seidler, Jiahui Lu, Gregory M Rosenberg, Ke Hou, Romany Abskharon, Hope Pan, Chih-Te Zee, David R Boyer, Yan Li, Daniel H Anderson, Kevin A Murray, Genesis Falcon, Duilio Cascio, Lorena Saelices, Robert Damoiseaux, Vaithilingaraja Arumugaswami, Feng Guo, David S Eisenberg

Journal: Nat Commun

PubMed ID: 37185252

Doi: 10.1038/s41467-023-37865-3

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Authors: Xiaofan Jia, Fran Dong, Laura Pyle, Aaron W Michels, Liping Yu, Marian Rewers

Journal: Diabetes Technol Ther

PubMed ID: 36989496

Doi: 10.1089/dia.2023.0016

Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder

Authors: Gaojia Zhang, Ling Li, Yan Kong, Dandan Xu, Yu Bao, Zhiting Zhang, Zhixiang Liao, Jiao Jiao, Dandan Fan, Xiaojing Long, Ji Dai, Chunming Xie, Zhiqiang Meng, Zhijun Zhang

Journal: Genes Dis

PubMed ID: 37692510

Doi: 10.1016/j.gendis.2023.02.049

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A cellular screening platform, stably expressing DENV2 NS5, defines a novel anti-DENV mechanism of action of Apigenin based on STAT2 activation

Authors: Chiara Acchioni, Marta Acchioni, Flavia Mancini, Antonello Amendola, Giulia Marsili, Valentina Tirelli, Chin Piaw Gwee, Kitti Wing-Ki Chan, Silvia Sandini, Monica Bisbocci, Mohamed Mysara, Mahmoud ElHefnawi, Massimo Sanchez, Giulietta Venturi, Maria Letizia Barreca, Giuseppe Manfroni, Alberto Bresciani, Subhash G Vasudevan, Marco Sgarbanti

Journal: Virology

PubMed ID: 37060797

Doi: 10.1016/j.virol.2023.03.016

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IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer

Authors: Qian Zhao, Lu Qian, Yuefan Guo, Jinhui Lü, Danni Li, Heying Xie, Qiong Wang, Wenjing Ma, Pengfei Liu, Yu Liu, Tao Wang, Xuebiao Wu, Junyi Han, Zuoren Yu

Journal: Theranostics

PubMed ID: 37153732

Doi: 10.7150/thno.82538

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Discovery of Lactomodulin, a Unique Microbiome-Derived Peptide That Exhibits Dual Anti-Inflammatory and Antimicrobial Activity against Multidrug-Resistant Pathogens

Authors: Walaa K Mousa, Rose Ghemrawi, Tareq Abu-Izneid, Azza Ramadan, Farah Al-Marzooq

Journal: Int J Mol Sci

PubMed ID: 37108065

Doi: 10.3390/ijms24086901

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Design, synthesis, and biological evaluation of novel napabucasin-melatonin hybrids as potent STAT3 inhibitors

Authors: Chong Zhang, Limin Yang, Xiaojuan Yang, Qinghe Gao, Yan Qu, Liqiang Wu

Journal: Bioorg Chem

PubMed ID: 37062104

Doi: 10.1016/j.bioorg.2023.106541

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Development and Evaluation of a Competitive Enzyme-Linked Immunosorbent Assay Based on Swine Monoclonal Antibodies for Detecting Neutralizing Antibodies against Senecavirus A

Authors: Xueqing Ma, Jiaxin Huang, Kun Li, Kailu Ding, Yuanfang Fu, Jing Zhang, Zhixun Zhao, Pinghua Li, Xingwen Bai, Dong Li, Xia Liu, Qiaoying Zeng, Zaixin Liu, Pu Sun, Zengjun Lu

Journal: Microbiol Spectr

PubMed ID: 37036366

Doi: 10.1128/spectrum.04599-22

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Expansion of circulating stem-like CD8 T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice

Authors: Kateryna Onyshchenko, Ren Luo, Elena Guffart, Simone Gaedicke, Anca-Ligia Grosu, Elke Firat, Gabriele Niedermann

Journal: Nat Commun

PubMed ID: 37045833

Doi: 10.1038/s41467-023-37825-x

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The functional and evolutionary impacts of human-specific deletions in conserved elements

Authors: James R Xue, Ava Mackay-Smith, Kousuke Mouri, Meilin Fernandez Garcia, Michael X Dong, Jared F Akers, Mark Noble, Xue Li, Kerstin Lindblad-Toh, Elinor K Karlsson, James P Noonan, Terence D Capellini, Kristen J Brennand, Ryan Tewhey, Pardis C Sabeti, Steven K Reilly

Journal: Science

PubMed ID: 37104592

Doi: 10.1126/science.abn2253

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Water Cannot Activate Traps of the Carnivorous Sundew Plant : On the Trail of Darwin's 150-Years-Old Mystery

Authors: Andrej Pavlovič, Ondřej Vrobel, Petr Tarkowski

Journal: Plants (Basel)

PubMed ID: 37176877

Doi: 10.3390/plants12091820

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ICOR: improving codon optimization with recurrent neural networks

Authors: Rishab Jain, Aditya Jain, Elizabeth Mauro, Kevin LeShane, Douglas Densmore

Journal: BMC bioinformatics

PubMed ID: 37016283

Doi: 10.1186/s12859-023-05246-8

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A cationic motif upstream Engrailed2 homeodomain controls cell internalization through selective interaction with heparan sulfates

Authors: Sébastien Cardon, Yadira P Hervis, Gérard Bolbach, Chrystel Lopin-Bon, Jean-Claude Jacquinet, Françoise Illien, Astrid Walrant, Delphine Ravault, Bingwei He, Laura Molina, Fabienne Burlina, Olivier Lequin, Alain Joliot, Ludovic Carlier, Sandrine Sagan

Journal: Nat Commun

PubMed ID: 37032404

Doi: 10.1038/s41467-023-37757-6

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Sustained secretion of human growth hormone from TheraCyte devices encapsulated with PiggyBac-engineered retinal pigment epithelium cells

Authors: Claudia R Cecchi, Sidsel Alsing, Gustavo P P Jesus, Enio A Zacarias, Lisbeth Kjaer, Michelle S Clement, Makiko Kumagai-Braesch, Thomas J Corydon, Paolo Bartolini, Cibele N Peroni, Lars Aagaard

Journal: Tissue Cell

PubMed ID: 37087908

Doi: 10.1016/j.tice.2023.102095

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ACD-containing chaperones reveal the divergent thermo-tolerance in penaeid shrimp

Authors: Xiaoxi Zhang, Xiaojun Zhang, Jianbo Yuan, Fuhua Li

Journal: science of the total environment

PubMed ID: 37023801

Doi: 10.1016/j.scitotenv.2023.163239

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A Versatile Platform for the Tumor-Targeted Intracellular Delivery of Peptides, Proteins, and siRNA

Authors: Yifan Yang, Haichao Zhu, Dingkang Liu, Hong Luo, Ruilong Chang, Yue Ji, Wenbing Yao, Jun Yin, Xiangdong Gao

Journal: advanced fucntional materials

Doi: 10.1002/adfm.202301011

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Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease

Authors: Xiaofeng Zhang, Fenghua Yang, Xiechao Zhan , Tong Bian, Zhihan Xing, Yichen Lu, Yigong Shi

Journal: Molecular Cell

PubMed ID: 37028420

Doi: 10.1016/j.molcel.2023.03.015

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Study of NIT domain-containing chemoreceptors from two global phytopathogens and identification of NIT domains in eukaryotes

Authors: Elizabet Monteagudo-Cascales, Álvaro Ortega, Félix Velando, Bertrand Morel, Miguel A Matilla, Tino Krell

Journal: Mol Microbiol

PubMed ID: 37186477

Doi: 10.1111/mmi.15069

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Lactucin Synthase Inactivation Boosts the Accumulation of Anti-inflammatory 8-Deoxylactucin and Its Derivatives in Chicory ( L)

Authors: Katarina Cankar, Johanna Christina Hakkert, Robert Sevenier, Christina Papastolopoulou, Bert Schipper, João P Baixinho, Naiara Fernández, Melanie S Matos, Ana Teresa Serra, Claudia Nunes Santos, Khabat Vahabi, Alain Tissier, Paul Bundock, Dirk Bosch

Journal: J Agric Food Chem

PubMed ID: 37036799

Doi: 10.1021/acs.jafc.2c08959

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Kinetic characterization and phylogenetic analysis of human ADP-dependent glucokinase reveal new insights into its regulatory properties

Authors: Alejandra Herrera-Morandé, Gabriel Vallejos-Baccelliere, Pablo A Cea, Ricardo A Zamora, Dixon Cid, Pablo Maturana, Felipe González-Ordenes, Víctor Castro-Fernández, Victoria Guixé

Journal: Arch Biochem Biophys

PubMed ID: 37084804

Doi: 10.1016/j.abb.2023.109602

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Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions

Authors: He-Wei Jiang, Hong Chen, Yun-Xiao Zheng, Xue-Ning Wang, Qingfeng Meng, Jin Xie, Jiong Zhang, ChangSheng Zhang, Zhao-Wei Xu, Zi-Qing Chen, Lei Wang, Wei-Sha Kong, Kuan Zhou, Ming-Liang Ma, Hai-Nan Zhang, Shu-Juan Guo, Jun-Biao Xue, Jing-Li Hou, Zhe-Yi Liu, Wen-Xue Niu, Fang-Jun Wang, Tao Wang, Wei Li, Rui-Na Wang, Yong-Jun Dang, Daniel M Czajkowsky, JianFeng Pei, Jia-Jia Dong, Sheng-Ce Tao

Journal: Sci China Life Sci

PubMed ID: 37059927

Doi: 10.1007/s11427-023-2316-2

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Transcriptional regulation of autophagy by chromatin remodeling complex and histone variant

Authors: Xin Li, Shanshan Wang, Xilan Yu, Shanshan Li

Journal: Autophagy

PubMed ID: 37039545

Doi: 10.1080/15548627.2023.2200352

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Deep mutational scanning highlights a new role for cytosolic regions in Hrd1 function

Authors: Brian G Peterson, Jiwon Hwang, Jennifer E Russ, Jeremy Schroeder, Peter L Freddolino, Ryan D Baldridge