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High light triggers flavonoid and polysaccharide synthesis through DoHY5-dependent signaling in Dendrobium officinale

Authors: Dongxiao Li, Guangying Ye, Jie Li, Zhenqin Lai, Siyou Ruan, Qi Qi, Zaihua Wang, Sujuan Duan, Hong-Lei Jin, Hong-Bin Wang

Journal: Plant J

PubMed ID: 37177908

Doi: 10.1111/tpj.16284

Products & Services: Proteins, Expression, Isolation and Analysis

Optimal Expression, Function, and Immunogenicity of an HIV-1 Vaccine Derived from the Approved Ebola Vaccine, rVSV-ZEBOV

Authors: Hiva Azizi, Jason P Knapp, Yue Li, Alice Berger, Marc-Alexandre Lafrance, Jannie Pedersen, Marc-Antoine de la Vega, Trina Racine, Chil-Yong Kang, Jamie F S Mann, Jimmy D Dikeakos, Gary Kobinger, Eric J Arts

Journal: Vaccines (Basel)

PubMed ID: 37243081

Doi: 10.3390/vaccines11050977

Products & Services: Proteins, Expression, Isolation and Analysis

African Swine Fever Virus HLJ/18 CD2v Suppresses Type I IFN Production and IFN-Stimulated Genes Expression through Negatively Regulating cGMP-AMP Synthase-STING and IFN Signaling Pathways

Authors: Li Huang, Weiye Chen, Hongyang Liu, Mengdi Xue, Siqi Dong, Xiaohong Liu, Chunying Feng, Shinuo Cao, Guangqiang Ye, Qiongqiong Zhou, Zhaoxia Zhang, Jun Zheng, Jiangnan Li, Dongming Zhao, Zilong Wang, Encheng Sun, Hefeng Chen, Shuai Zhang, Xue Wang, Xianfeng Zhang, Xijun He, Yuntao Guan, Zhigao Bu, Changjiang Weng

Journal: J Immunol

PubMed ID: 36971697

Doi: 10.4049/jimmunol.2200813

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 omicron variants harbor spike protein mutations responsible for their attenuated fusogenic phenotype

Authors: Seung Bum Park, Mohsin Khan, Sai Chaitanya Chiliveri, Xin Hu, Parker Irvin, Madeleine Leek, Ailis Grieshaber, Zongyi Hu, Eun Sun Jang, Ad Bax, T Jake Liang

Journal: Commun Biol

PubMed ID: 37225764

Doi: 10.1038/s42003-023-04923-x

Products & Services: Gene Synthesis

Non-invasive activation of intratumoural gene editing for improved adoptive T-cell therapy in solid tumours

Authors: Xiaohong Chen, Shuang Wang, Yuxuan Chen, Huhu Xin, Shuaishuai Zhang, Di Wu, Yanan Xue, Menglei Zha, Hongjun Li, Kai Li, Zhen Gu, Wei Wei, Yuan Ping

Journal: NATURE NANOTECHNOLOGY

PubMed ID: 37188968

Doi: 10.1038/s41565-023-01378-3

Products & Services: Recombinant Proteins

Refining the genomic determinants underlying escape from X-chromosome inactivation

Authors: Samantha Peeters, Tiffany Leung, Oriol Fornes, Rachelle A Farkas, Wyeth W Wasserman, Carolyn J Brown

Journal: NAR genomic and bioimformatics

PubMed ID: 37260510

Doi: 10.1093/nargab/lqad052

Products & Services: Gene Synthesis

DPY30 Promotes Proliferation and Cell Cycle Progression of Colorectal Cancer Cells via Mediating H3K4 Trimethylation

Authors: Wei-Chao Su, Xiao-Mei Mao, Si-Yang Li, Chun-Ying Luo, Rui Fan, Hai-Feng Jiang, Lin-Jun Zhang, Ya-Tao Wang, Guo-Qiang Su, Dong-Yan Shen

Journal: Int J Med Sci

PubMed ID: 37324189

Doi: 10.7150/ijms.80073

Products & Services: Proteins, Expression, Isolation and Analysis

The global regulator SpoVG regulates Listeria monocytogenes biofilm formation

Authors: Changzheng Shi, Liping Zheng, Zhaoxin Lu, Xinyi Zhang, Xiaomei Bie

Journal: Microb Pathog

PubMed ID: 37148923

Doi: 10.1016/j.micpath.2023.106144

Products & Services: Proteins, Expression, Isolation and Analysis

Divergent expression of aristaless1 and aristaless2 during embryonic appendage and pupal wing development in butterflies

Authors: Erick X Bayala, Isabella Cisneros, Darli Massardo, Nicholas W VanKuren, Marcus R Kronforst

Journal: BMC Biol

PubMed ID: 37170114

Doi: 10.1186/s12915-023-01602-5

Products & Services: Peptide Synthesis

In silico design and validation of a novel multi-epitope vaccine candidate against structural proteins of Chikungunya virus using comprehensive immunoinformatics analyses

Authors: Shirin Mahmoodi, Javad Zamani Amirzakaria, Abdolmajid Ghasemian

Journal: PLoS ONE

PubMed ID: 37146081

Doi: 10.1371/journal.pone.0285177

Products & Services: Codon Optimization

Profiling Enzyme Activity of l-Asparaginase II by NMR-Based Methyl Fingerprinting at Natural Abundance

Authors: Rachayita Nag, Srishti Joshi, Anurag Singh Rathore, Subhabrata Majumder

Journal: J Am Chem Soc

PubMed ID: 37154467

Doi: 10.1021/jacs.3c02154

Products & Services: DNA Sequencing

Heterologous Expression of Plantaricin 423 and Mundticin ST4SA in Saccharomyces cerevisiae

Authors: Michelle Rossouw, Rosemary A Cripwell, Ross R Vermeulen, Anton D van Staden, Willem H van Zyl, Leon M T Dicks, Marinda Viljoen-Bloom

Journal: Probiotics Antimicrob Proteins

PubMed ID: 37171691

Doi: 10.1007/s12602-023-10082-6

Products & Services: Molecular Biology Reagents

Structural Characterization of the Staphylococcus aureus Targeting Lectin Peptides from Garlic (Allium sativum L) by Liquid Nitrogen Grinding Coupled with the Proteomic and Antimicrobial Mechanism Analysis

Authors: Shuqin Li, Nannan Li, Yajie Wang, Xiaoyu Zhang, Jia Wang, Min Zhang, Haixia Chen

Journal: Probiotics Antimicrob Proteins

PubMed ID: 37217612

Doi: 10.1007/s12602-023-10078-2

Products & Services: Proteins, Expression, Isolation and Analysis

Adaptive evolution to the natural and anthropogenic environment in a global invasive crop pest, the cotton bollworm

Authors: Minghui Jin, Henry L. North, Yan Peng, Hangwei Liu,, Bo Liu,, Ruiqing Pan, Yan Zhou, Weigang Zheng, Kaiyu Liu, Bo Yang, Lei Zhang, Qi Xu, Samia Elfekih,Wendy A. Valencia-Montoya, Tom Walsh, Peng Cui, Yongfeng Zhou, Kenneth Wilson, Chris Jiggins,Kongming Wu,and Yutao Xiao,

Journal: The Innovation

Doi: 10.1016/j.xinn.2023.100454

Products & Services: Gene Synthesis

Engineered ketocarotenoid biosynthesis in the polyextremophilic red microalga Cyanidioschyzon merolae 10D

Authors: Mark Seger , Fakhriyya Mammadova , Melany Villegas-Valencia , Barbara ´ Bastos de Freitas , Clarissa Chang , Iona Isachsen , Haley Hemstreet , Fatimah Abualsaud , Malia Boring , Peter J. Lammers , Kyle J. Lauersen

Journal: Metabolic Engineering Communications

Doi: 10.1016/j.mec.2023.e00226

Products & Services: Gene Synthesis

MASP3 Deficiency in Mice Reduces but Does Not Abrogate Alternative Pathway Complement Activity Due to Intrinsic Profactor D Activity

Authors: Damodar Gullipalli, Takashi Miwa, Madhu Golla, Sayaka Sato, Sree Angampalli, Wen-Chao Song

Journal: J Immunol

PubMed ID: 36988282

Doi: 10.4049/jimmunol.2200932

Products & Services: Gene Synthesis

Development and characterization of nanobodies that specifically target the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) and impact its interaction with a known binding partner, CNNM3

Authors: Caroline N Smith, Kyle Kihn, Zachary A Williamson, K Martin Chow, Louis B Hersh, Konstantin V Korotkov, Daniel Deredge, Jessica S Blackburn

Journal: PLoS ONE

PubMed ID: 37220097

Doi: 10.1371/journal.pone.0285964

Products & Services: Proteins, Expression, Isolation and Analysis

Ovarian juvenile granulosa cell tumors with Ollier's disease in children with IDH1 gene somatic mutation

Authors: Jin Zhang, Renwu Hua, Lishuang Ma, Chao Liu, Yanxia Zhang, Xuemin Lü, Tianren Wang, Naijun Wan

Journal: Front Endocrinol (Lausanne)

PubMed ID: 37324278

Doi: 10.3389/fendo.2023.1093273

Products & Services: Proteins, Expression, Isolation and Analysis

Prognostic impact of kallikrein-related peptidase transcript levels in prostate cancer

Authors: Timo-Pekka K Lehto, Ruusu-Maaria Kovanen, Susanna Lintula, Adrian Malén, Carolin Stürenberg, Andrew Erickson, Olli-Pekka Pulkka, Ulf-Håkan Stenman, Eleftherios P Diamandis, Antti Rannikko, Tuomas Mirtti, Hannu Koistinen

Journal: Int J Cancer

PubMed ID: 37139608

Doi: 10.1002/ijc.34551

Products & Services: Molecular Biology Reagents

Synthesis and Evaluation of Clinically Translatable Targeted Microbubbles Using a Microfluidic Device for In Vivo Ultrasound Molecular Imaging

Authors: Rakesh Bam, Arutselvan Natarajan, Farbod Tabesh, Ramasamy Paulmurugan, Jeremy J Dahl

Journal: Int J Mol Sci

PubMed ID: 37240396

Doi: 10.3390/ijms24109048

Products & Services: Recombinant Proteins

Soluble monomeric human programmed cell death-ligand 1 inhibits the functions of activated T cells

Authors: Zhaoduan Liang, Wenfang Chen, Yunzhuo Guo, Yuefei Ren, Ye Tian, Wenxuan Cai, Yifeng Bao, Qi Liu, Peng Ding, Yi Li

Journal: Front Immunol

PubMed ID: 37266424

Doi: 10.3389/fimmu.2023.1133883

Products & Services: Stable Cell Lines

Identification of new conserved linear B-cell epitopes in the 3AB and 3C protein of Senecavirus A

Authors: Jian Li, Junfang Yan, Yanni Gao, Xing Liu, Haifeng Sun, Juan Bai, Ping Jiang

Journal: Vet Microbiol

PubMed ID: 37263042

Doi: 10.1016/j.vetmic.2023.109780

Products & Services: Custom DNA/RNA Oligos

BcMYB111 Responds to BcCBF2 and Induces Flavonol Biosynthesis to Enhance Tolerance under Cold Stress in Non-Heading Chinese Cabbage

Authors: Xiaoshan Chen , Ying Wu , Zhanghong Yu , Zhanyuan Gao , Qiang Ding , Sayyed Hamad Ahmad Shah , Wenyuan Lin , Ying Li , Xilin Hou

Journal: Int J Mol Sci .

PubMed ID: 37240015

Doi: 10.3390/ijms24108670

Products & Services: Gene Synthesis

Safety and Efficacy of Intravenous and Intrathecal Delivery of AAV9-Mediated ARSA in Minipigs

Authors: Aysilu Mullagulova , Alisa Shaimardanova , Valeriya Solovyeva , Yana Mukhamedshina , Daria Chulpanova , Alexander Kostennikov, Shaza Issa, Albert Rizvanov

Journal: Int J Mol Sci .

PubMed ID: 37298156

Doi: 10.3390/ijms24119204

Products & Services: Gene Synthesis

Site-specific gene knock-in and bacterial phytase gene expression in Cas9 RNP-mediated HDR

Authors: Hassan Zadabbas Shahabadi, Arash Akbarzadeh, Hamideh Ofoghi, Saeid Kadkhodaei

Journal: Front Plant Sci

PubMed ID: 37275253

Doi: 10.3389/fpls.2023.1150436

Products & Services: Proteins, Expression, Isolation and Analysis

An Aurora B-RPA signaling axis secures chromosome segregation fidelity

Authors: Poonam Roshan, Sahiti Kuppa, Jenna R Mattice, Vikas Kaushik, Rahul Chadda, Nilisha Pokhrel, Brunda R Tumala, Aparna Biswas, Brian Bothner, Edwin Antony, Sofia Origanti

Journal: Nat Commun

PubMed ID: 37230964

Doi: 10.1038/s41467-023-38711-2

Products & Services: Codon Optimization

Chronic intermittent hypobaric hypoxia ameliorates osteoporosis after spinal cord injury through balancing osteoblast and osteoclast activities in rats

Authors: Li Zhang, Yingchao Yin, Jialiang Guo, Lin Jin, Zhiyong Hou

Journal: Front Endocrinol (Lausanne)

PubMed ID: 37229453

Doi: 10.3389/fendo.2023.1035186

Products & Services: PCR Cloning and Subcloning

Hemophore-like proteins produced by periodontopathogens are recognized by the host immune system and react differentially with IgG antibodies

Authors: Michał Śmiga, Klaudia Siemińska, Soraya C Trindade, Isaac S Gomes-Filho, Ellen K Nobre Dos Santos, Teresa Olczak

Journal: J Oral Microbiol

PubMed ID: 37213663

Doi: 10.1080/20002297.2023.2214455

Products & Services: Peptide Synthesis

Rapid Quantitation of Various Therapeutic Monoclonal Antibodies Using Membranes with Fc-Specific Ligands

Authors: Junyan Yang, Raluca Ostafe, Christopher J Welch, Brandy Verhalen, Ivan L Budyak, Merlin L Bruening

Journal: Anal Chem

PubMed ID: 37216615

Doi: 10.1021/acs.analchem.3c00531

Products & Services: Peptide Synthesis

Hijacking of Host Plasminogen by () via GAPDH: an Important Virulence Mechanism To Promote Adhesion and Extracellular Matrix Degradation

Authors: Jiying Wang, Shiyang Li, Junhong Chen, Lanxi Gan, Jia Wang, Qiyan Xiong, Zhixin Feng, Quan Li, Zhibang Deng, Xiaomin Yuan, Yanfei Yu

Journal: Microbiol Spectr

PubMed ID: 37199643

Doi: 10.1128/spectrum.00218-23

Products & Services: Molecular Biology Reagents

Ionic displacement of Ca by Pb in calmodulin is affected by arrhythmia-associated mutations

Authors: Valerio Marino, Giuditta Dal Cortivo, Daniele Dell'Orco

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 37201768

Doi: 10.1016/j.bbamcr.2023.119490

Products & Services: Codon Optimization

KREH1 RNA helicase activity promotes utilization of initiator gRNAs across multiple mRNAs in trypanosome RNA editing

Authors: Ashutosh P Dubey, Brianna L Tylec, Amartya Mishra, Katherine Sortino, Runpu Chen, Yijun Sun, Laurie K Read

Journal: Nucleic Acids Research

PubMed ID: 37140035

Doi: doi.org/10.1093/nar/gkad292

Products & Services: Gene Synthesis

Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex

Authors: Mandy S M Wan, Reyhan Muhammad, Marios G Koliopoulos, Theodoros I Roumeliotis, Jyoti S Choudhary, Claudio Alfieri

Journal: nature communications

PubMed ID: 37137925

Doi: 10.1038/s41467-023-38276-0

Products & Services: Gene Synthesis

Ligand and G-protein selectivity in the κ-opioid receptor

Authors: Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che

Journal: Nature

PubMed ID: 37138078

Doi: 10.1038/s41586-023-06030-7

Products & Services: Proteins, Expression, Isolation and Analysis

Diversity and Genetic Reassortment of Keystone Virus in Mosquito Populations in Florida

Authors: Maha A Elbadry, Caroline A Efstathion, Whitney A Qualls, Massimiliano S Tagliamonte, Md Mahbubul Alam, Md Siddiqur Rahman Khan, Sadie J Ryan, Rui-de Xue, Remi N Charrel, Lea Bangonan, Marco Salemi, Nazli Ayhan, John A Lednicky, J Glenn Morris

Journal: Am J Trop Med Hyg

PubMed ID: 37127267

Doi: 10.4269/ajtmh.22-0594

Products & Services: Proteins, Expression, Isolation and Analysis

Bioluminescence resonance energy transfer biosensor for measuring activity of a protease secreted by Pseudomonas fluorescens growing in milk

Authors: H Dacres, F Weihs, J Wang, A Anderson, S C Trowell

Journal: Anal Chim Acta

PubMed ID: 37311608

Doi: 10.1016/j.aca.2023.341401

Products & Services: Proteins, Expression, Isolation and Analysis

Photobiomodulation therapy at 632 nm wavelength ameliorates intrauterine adhesion via activation of cAMP/PKA/CREB pathway

Authors: Hongjie Zheng, Caixia Wang, Shan Wu, Qing Pei, Min Yao

Journal: Photochem Photobiol

PubMed ID: 37212452

Doi: 10.1111/php.13813

Products & Services: Proteins, Expression, Isolation and Analysis

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

Authors: Damon A Hofman, Jorge Ruiz-Orera, Ian Yannuzzi, Rakesh Murugesan, Adam Brown, Karl R Clauser, Alexandra L Condurat, Jip T van Dinter, Sem A G Engels, Amy Goodale, Jasper van der Lugt, Tanaz Abid, Li Wang, Kevin N Zhou, Jayne Vogelzang, Keith L Ligon, Timothy N Phoenix, Jennifer A Roth, David E Root, Norbert Hubner, Todd R Golub, Pratiti Bandopadhayay, Sebastiaan van Heesch, John R Prensner

Journal: biorxiv

PubMed ID: 37205492

Doi: 10.1101/2023.05.04.539399

Products & Services: Proteins, Expression, Isolation and Analysis

The secretory IgA (sIgA) response in human milk against the SARS-CoV-2 Spike is highly durable and neutralizing for at least 1 year of lactation post-infection

Authors: Xiaoqi Yang, Alisa Fox, Claire DeCarlo, Nicole Pineda, Rebecca L R Powell

Journal: medrxiv

PubMed ID: 37293109

Doi: 10.1101/2023.05.19.23290192

Products & Services: Proteins, Expression, Isolation and Analysis

Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes

Authors: Charles S Lay, Albert Isidro-Llobet, Laura E Kilpatrick, Peter D Craggs, Stephen J Hill

Journal: Nat Commun

PubMed ID: 37208328

Doi: 10.1038/s41467-023-38541-2

Products & Services: Proteins, Expression, Isolation and Analysis

Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma

Authors: Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

Journal: Front Immunol

PubMed ID: 37304295

Doi: 10.3389/fimmu.2023.1182409

Products & Services: Insect Expression

Molecular cloning and in silico analysis of chalcone isomerase from Polygonum minus

Authors: Fatin Lyana Azman Shah, Syarul Nataqain Baharum, Hoe-Han Goh, Thean Chor Leow, Ahmad Bazli Ramzi, Siti Nurbaya Oslan, Suriana Sabri

Journal: Mol Biol Rep

PubMed ID: 37148413

Doi: 10.1007/s11033-023-08417-1

Products & Services: Recombinant Proteins

Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex

Authors: Cassandra K Hayne, Kevin John U Butay, Zachary D Stewart, Juno M Krahn, Lalith Perera, Jason G Williams, Robert M Petrovitch, Leesa J Deterding, A Gregory Matera, Mario J Borgnia, Robin E Stanley

Journal: Nat Struct Mol Biol

PubMed ID: 37231153

Doi: 10.1038/s41594-023-00991-z

Products & Services: Gene Synthesis

GNAQ-Regulated ZO-1 and ZO-2 Act as Tumor Suppressors by Modulating EMT Potential and Tumor-Repressive Microenvironment in Lung Cancer

Authors: Hyung Seok Kim, Su In Lee, Yu Rim Choi, Jiyun Kim, Jung Woo Eun, Kyoung Seob Song, Jee-Yeong Jeong

Journal: Int J Mol Sci

PubMed ID: 37240145

Doi: 10.3390/ijms24108801

Products & Services: Recombinant Proteins

FOSL2 promotes intertumoral infiltration of T cells and increases pathological complete response rates in locally advanced rectal cancer patients

Authors: Kailun Xu, Xiaoyang Yin, Biting Zhou, Xi Zheng, Hao Wang, Jing Chen, Xue Cai, Huanhuan Gao, Xiaoming Xu, Liuhong Wang, Li Shen, Tiannan Guo, Shu Zheng, Baosheng Li, Yingkuan Shao, Jian Wang

Journal: CANCER LETTERS

PubMed ID: 36997107

Doi: 10.1016/j.canlet.2023.216145

Products & Services: Synthetic sgRNA and crRNA Service

Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models

Authors: Junzhu Yi, Xinlin Lei, Fangteng Guo, Qiubing Chen, Xueyong Chen, Kaitao Zhao, Chengliang Zhu, Xiaoming Cheng, Jiangwei Lin, Hao Yin, Yuchen Xia

Journal: Antiviral research

PubMed ID: 37142191

Doi: 10.1016/j.antiviral.2023.105618

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Functionalized Metal–Organic Framework-Modified Hydrogel That Breaks the Vicious Cycle of Inflammation and ROS for Repairing of Diabetic Bone Defects

Authors: An Lao, Jiaqing Wu, Dejian Li, Aili Shen, Yaxin Li, Yu Zhuang, Kaili Lin, Jianyong Wu, Jiaqiang Liu

Journal: Small

PubMed ID: 37183293

Doi: smll.202206919

Products & Services: Proteins, Expression, Isolation and Analysis

Immunogenic SARS-CoV-2 S and N Protein Peptide and Cytokine Combinations as Biomarkers for Early Prediction of Fatal COVID-19

Authors: Ekaterina Martynova , Shaimaa Hamza , Maria Markelova , Ekaterina Garanina , Yuriy Davidyuk , Venera Shakirova , Neha Kaushal , Manoj Baranwal , Robert J Stott-Marshall , Toshana L Foster , Albert Rizvanov , Svetlana Khaiboullina

Journal: Front Immunol .

PubMed ID: 35386707

Doi: 10.3389/fimmu.2022.830715

Products & Services: Peptide Synthesis

In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g

Authors: Irina S. Abaeva, Yani Arhab, Anna Miscicka, Christopher U.T. Hellen, and Tatyana V. Pestova

Journal: bioRxiv .

PubMed ID: 37292671

Doi: 10.1101/gad.350829.123

Products & Services: Gene Synthesis

Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy

Authors: Stavroula Dionysopoulou, Per Wikstrom, Claudio Bucolo, Giovanni Luca Romano, Vincenzo Micale, Richard Svensson, Dimitris Spyridakos, Niki Mastrodimou, Spiros Georgakis, Panayotis Verginis, Erik Walum, Kyriaki Thermos

Journal: Diabetes

PubMed ID: 36821829

Doi: 10.2337/db22-0515

Products & Services: Proteins, Expression, Isolation and Analysis

The Nucleocapsid Proteins of SARS-CoV-2 and Its Close Relative Bat Coronavirus RaTG13 Are Capable of Inhibiting PKR- and RNase L-Mediated Antiviral Pathways

Authors: Kyle LeBlanc, Jessie Lynch, Christine Layne, Robert Vendramelli, Angela Sloan, Nikesh Tailor, Yvon Deschambault, Fushun Zhang, Darwyn Kobasa, David Safronetz, Yan Xiang, Jingxin Cao

Journal: Microbiol Spectr

PubMed ID: 37154717

Doi: 10.1128/spectrum.00994-23

Products & Services: Proteins, Expression, Isolation and Analysis

KRAS mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer

Authors: Chang Cai, Shuo Yao, Yanmei Zou, Hui Lu, Xiuqiong Chen, Yali Wang, Kun Zheng, Feng Zhu, Yihua Wang, Hua Xiong, Junfei Zhu

Journal: J Cell Mol Med

PubMed ID: 37226642

Doi: 10.1111/jcmm.17640

Products & Services: Proteins, Expression, Isolation and Analysis

Redundant actions of neuropeptides encoded by the dh-pban gene for larval color pattern formation in the oriental armyworm Mythimnaseparata

Authors: Yu Shirai, Hajime Ono, Takaaki Daimon

Journal: Insect Biochem Mol Biol

PubMed ID: 37146697

Doi: 10.1016/j.ibmb.2023.103955

Products & Services: Peptide Synthesis

Detection of viral RNAs at ambient temperature via reporter proteins produced through the target-splinted ligation of DNA probes

Authors: Elizabeth A Phillips, Adam D Silverman, Aric Joneja, Michael Liu, Carl Brown, Paul Carlson, Christine Coticchia, Kristen Shytle, Alex Larsen, Nadish Goyal, Vincent Cai, Jason Huang, Jennifer E Hickey, Emily Ryan, Joycelynn Acheampong, Pradeep Ramesh, James J Collins, William J Blake

Journal: Nat Biomed Eng

PubMed ID: 37142844

Doi: 10.1038/s41551-023-01028-y

Products & Services: Proteins, Expression, Isolation and Analysis

Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8 T cells

Authors: Leeana D Peters, Wen-I Yeh, Juan M Arnoletti, Matthew E Brown, Amanda L Posgai, Clayton E Mathews, Todd M Brusko

Journal: Front Immunol

PubMed ID: 37325626

Doi: 10.3389/fimmu.2023.1142648

Products & Services: Peptide Synthesis

Soluble TREM-like Transcript-1 Acts as a Damage-Associated Molecular Pattern through the TLR4/MD2 Pathway Contributing to Immune Dysregulation during Sepsis

Authors: Chia-Ming Chang, Kuang-Hua Cheng, Tsai-Yin Wei, Meng-Ping Lu, Yi-Chen Chen, Yen-Ta Lu

Journal: J Immunol

PubMed ID: 36961438

Doi: 10.4049/jimmunol.2200222

Products & Services: Proteins, Expression, Isolation and Analysis

Leveraging a Structural Blueprint to Rationally Engineer the Rieske Oxygenase TsaM

Authors: Jiayi Tian, Alejandro Arcadio Garcia, Patrick H Donnan, Jennifer Bridwell-Rabb

Journal: Biochemistry

PubMed ID: 37188334

Doi: 10.1021/acs.biochem.3c00150

Products & Services: Proteins, Expression, Isolation and Analysis

Antigen-Induced IL-1RA Production Discriminates Active and Latent Tuberculosis Infection

Authors: Cesar Sanchez, Luis Jaramillo-Valverde, Silvia Capristano, Gilmer Solis, Alonso Soto, Julio Valdivia-Silva, Julio A Poterico, Heinner Guio

Journal: Microorganisms

PubMed ID: 37374887

Doi: 10.3390/microorganisms11061385

Products & Services: Peptide Synthesis

Antibody blockade of Jagged1 attenuates choroidal neovascularization

Authors: Torleif Tollefsrud Gjølberg, Jonas Aakre Wik, Hanna Johannessen, Stig Krüger, Nicola Bassi, Panagiotis F Christopoulos, Malin Bern, Stian Foss, Goran Petrovski, Morten C Moe, Guttorm Haraldsen, Johanna Hol Fosse, Bjørn Steen Skålhegg, Jan Terje Andersen, Eirik Sundlisæter

Journal: Nat Commun

PubMed ID: 37253747

Doi: 10.1038/s41467-023-38563-w

Products & Services: Proteins, Expression, Isolation and Analysis

Small heterodimer partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation

Authors: JooYeon Jhun, Jeonghyeon Moon, Ji Ye Kwon, Keun-Hyung Cho, Seang Yoon Lee, Hyun Sik Na, Mi-La Cho, Jun-Ki Min

Journal: Cell Commun Signal

PubMed ID: 37143079

Doi: 10.1186/s12964-023-01054-y

Products & Services: Codon Optimization

Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest

Authors: Bipul R Acharya, Jennifer S Fang, Erin D Jeffery, Nicholas W Chavkin, Gael Genet, Hema Vasavada, Elizabeth A Nelson, Gloria M Sheynkman, Martin J Humphries, Karen K Hirschi

Journal: Life Sci Alliance

PubMed ID: 37197981

Doi: 10.26508/lsa.202201685

Products & Services: Molecular Biology Reagents

Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant

Authors: Nanami Senoo, Dinesh K Chinthapalli, Matthew G Baile, Vinaya K Golla, Bodhisattwa Saha, Oluwaseun B Ogunbona, James A Saba, Teona Munteanu, Yllka Valdez, Kevin Whited, Dror Chorev, Nathan N Alder, Eric R May, Carol V Robinson, Steven M Claypool

Journal: biorxiv

PubMed ID: 37205478

Doi: 10.1101/2023.05.05.539595

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GSK3 phosphorylates and regulates the Green Revolution protein Rht-B1b to reduce plant height in wheat

Authors: Huixue Dong, Danping Li, Ruizhen Yang, Lichao Zhang, Yunwei Zhang, Xu Liu, Xiuying Kong, Jiaqiang Sun

Journal: Plant Cell

PubMed ID: 36945740

Doi: 10.1093/plcell/koad090

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A highly efficient transgene knock-in technology in clinically relevant cell types

Authors: Alexander G Allen, Samia Q Khan, Carrie M Margulies, Ramya Viswanathan, Swarali Lele, Laura Blaha, Sean N Scott, Kaitlyn M Izzo, Alexandra Gerew, Rithu Pattali, Nadire R Cochran, Carl S Holland, Amy H Zhao, Stephen E Sherman, Michael C Jaskolka, Meng Wu, Aaron C Wilson, Xiaoqi Sun, Dawn M Ciulla, Deric Zhang, Jacqueline D Nelson, Peisheng Zhang, Patrizia Mazzucato, Yan Huang, Georgia Giannoukos, Eugenio Marco, Michael Nehil, John A Follit, Kai-Hsin Chang, Mark S Shearman, Christopher J Wilson, John A Zuris

Journal: Nat Biotechnol

PubMed ID: 37127662

Doi: 10.1038/s41587-023-01779-8

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Deep learning models to predict the editing efficiencies and outcomes of diverse base editors

Authors: Nahye Kim, Sungchul Choi, Sungjae Kim, Myungjae Song, Jung Hwa Seo, Seonwoo Min, Jinman Park, Sung-Rae Cho, Hyongbum Henry Kim

Journal: Nat Biotechnol

PubMed ID: 37188916

Doi: 10.1038/s41587-023-01792-x

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Structure of a 10-23 Deoxyribozyme Exhibiting a Homodimer Conformation

Authors: Evan Cramer, Sarah Starcovic, Rebekah Avey, Ali Kaya, Aaron Robart

Journal: Res Sq

PubMed ID: 37398199

Doi: 10.21203/rs.3.rs-2252941/v1

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Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy

Authors: Nikolas T Martin, Mathieu J F Crupi, Zaid Taha, Joanna Poutou, Jack T Whelan, Sydney Vallati, Julia Petryk, Ricardo Marius, Bradley Austin, Taha Azad, Mason Boulanger, Tamara Burgess, Ilson Sanders, Camille Victoor, Bryan C Dickinson, Jean-Simon Diallo, Carolina S Ilkow, John C Bell

Journal: Pharmaceuticals (Basel)

PubMed ID: 37242495

Doi: 10.3390/ph16050709

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Evaluation of humoral and cellular immune responses induced by a cocktail of recombinant African swine fever virus antigens fused with OprI in domestic pigs

Authors: Guanglei Zhang, Wei Liu, Sicheng Yang, Shuai Song, Yunyun Ma, Guangqing Zhou, Xiaxia Liang, Chun Miao, Junhui Li, Yanhong Liu, Junjun Shao, Huiyun Chang

Journal: Virol J

PubMed ID: 37237390

Doi: 10.1186/s12985-023-02070-7

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Design and development of microformulations for rapid release of small molecules and oligonucleotides

Authors: T Brown, M Stanton, F Cros, S Cho, A Kiselyov

Journal: Eur J Pharm Sci

PubMed ID: 37220816

Doi: 10.1016/j.ejps.2023.106472

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Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core

Authors: Pantelis Poumbourios, Christine Langer, Irene Boo, Tasnim Zakir, Rob J Center, Anouschka Akerman, Vanessa Milogiannakis, Anupriya Aggarwal, Bronte A Johnstone, Jungmin Ha, Fasséli Coulibaly, Stuart G Turville, Heidi E Drummer

Journal: PLoS Pathog

PubMed ID: 37200378

Doi: 10.1371/journal.ppat.1010981

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Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in knock-out mammalian cells

Authors: Gábor Tax, Kevin P Guay, Tatiana Soldà, Charlie J Hitchman, Johan C Hill, Snežana Vasiljević, Andrea Lia, Carlos P Modenutti, Kees R Straatman, Angelo Santino, Maurizio Molinari, Nicole Zitzmann, Daniel N Hebert, Pietro Roversi, Marco Trerotola

Journal: biorxiv

PubMed ID: 37398215

Doi: 10.1101/2023.05.30.542711

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The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis

Authors: Jennilee M Davidson, Sharlynn S L Wu, Stephanie L Rayner, Flora Cheng, Kimberley Duncan, Carlo Russo, Michelle Newbery, Kunjie Ding, Natalie M Scherer, Rachelle Balez, Alberto García-Redondo, Alberto Rábano, Livia Rosa-Fernandes, Lezanne Ooi, Kelly L Williams, Marco Morsch, Ian P Blair, Antonio Di Ieva, Shu Yang, Roger S Chung, Albert Lee

Journal: Mol Neurobiol

PubMed ID: 37243816

Doi: 10.1007/s12035-023-03355-2

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saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity against SARS-CoV-2 variants of concern

Authors: Mai Komori, Takuto Nogimori, Amber L Morey, Takashi Sekida, Keiko Ishimoto, Matthew R Hassett, Yuji Masuta, Hirotaka Ode, Tomokazu Tamura, Rigel Suzuki, Jeff Alexander, Yasutoshi Kido, Kenta Matsuda, Takasuke Fukuhara, Yasumasa Iwatani, Takuya Yamamoto, Jonathan F Smith, Wataru Akahata

Journal: Nat Commun

PubMed ID: 37208330

Doi: 10.1038/s41467-023-38457-x

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Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response

Authors: Shridhar Bale, Lifei Yang, Mehrdad Alirezaei, Richard Wilson, Takayuki Ota, Esmeralda D Doyle, Christopher A Cottrell, Javier Guenaga, Karen Tran, Wenjuan Li, Leonidas Stamatatos, David Nemazee, Andrew B Ward, Richard T Wyatt

Journal: Front Immunol

PubMed ID: 37283743

Doi: 10.3389/fimmu.2023.1180959

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CFTR and dystrophin encoding plasmids carrying both luciferase reporter gene, nuclear import specific sequences and triple helix sites

Authors: Delphine Maze, Caroline Girardin, Nathalie Benz, Tristan Montier, Chantal Pichon, Patrick Midoux

Journal: Plasmid

PubMed ID: 37207938

Doi: 10.1016/j.plasmid.2023.102686

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Inflammation Modifies miR-21 Expression Within Neuronal Extracellular Vesicles to Regulate Remyelination Following Spinal Cord Injury

Authors: Tianyu Han, Peiwen Song, Zuomeng Wu, Yunlei Liu, Wang Ying, Cailiang Shen

Journal: Stem Cell Rev Rep

PubMed ID: 37256514

Doi: 10.1007/s12015-023-10560-y

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Predictive data-driven modeling of C-terminal tyrosine function in the EGFR signaling network

Authors: Jacqueline S Gerritsen, Joseph S Faraguna, Rudy Bonavia, Frank B Furnari, Forest M White

Journal: Life Sci Alliance

PubMed ID: 37169593

Doi: 10.26508/lsa.202201466

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Deep sampling of gRNA in the human genome and deep-learning-informed prediction of gRNA activities

Authors: Heng Zhang, Jianfeng Yan, Zhike Lu, Yangfan Zhou, Qingfeng Zhang, Tingting Cui, Yini Li, Hui Chen, Lijia Ma

Journal: Cell Discov

PubMed ID: 37193681

Doi: 10.1038/s41421-023-00549-9

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Simultaneous enhancement of multiple functional properties using evolution-informed protein design

Authors: Benjamin Fram, Ian Truebridge, Yang Su, Adam J Riesselman, John B Ingraham, Alessandro Passera, Eve Napier, Nicole N Thadani, Samuel Lim, Kristen Roberts, Gurleen Kaur, Michael Stiffler, Debora S Marks, Christopher D Bahl, Amir R Khan, Chris Sander, Nicholas P Gauthier

Journal: biorxiv

PubMed ID: 37214973

Doi: 10.1101/2023.05.09.539914

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Preparation of magnetic polyacrylamide hydrogel with chitosan for immobilization of glutamate decarboxylase to produce γ-aminobutyric acid

Authors: Jianjun Wang, Luyao Wang, Chengli Yang, Yihui Zhu, Ziqian Chen, Guanya He, Kaishun Hu, Kaixuan Liu, Beibei Fang, Dali Li, Ruofu Shi

Journal: Prep Biochem Biotechnol

PubMed ID: 37184437

Doi: 10.1080/10826068.2023.2209884

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Reticular adhesions are assembled at flat clathrin lattices and opposed by active integrin α5β1

Authors: Laura Hakanpää, Amr Abouelezz, An-Sofie Lenaerts, Seyda Culfa, Michael Algie, Jenny Bärlund, Pekka Katajisto, Harvey McMahon, Leonardo Almeida-Souza

Journal: J Cell Biol

PubMed ID: 37233325

Doi: 10.1083/jcb.202303107

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Arabidopsis calmodulin-like proteins CML13 and CML14 interact with proteins that have IQ domains

Authors: Howard J Teresinski, Bryan Hau, Kyle Symonds, Ryan Kilburn, Kim A Munro, Nathan M Doner, Robert Mullen, Vivian H Li, Wayne A Snedden

Journal: Plant Cell Environ

PubMed ID: 37222394

Doi: 10.1111/pce.14616

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Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants

Authors: Jianbo Wu, Zhenguo Chen, Yidan Gao, Zegen Wang, Jiarong Wang, Bing-Yu Chiang, Yunjiao Zhou, Yuru Han, Wuqiang Zhan, Minxiang Xie, Weiyu Jiang, Xiang Zhang, Aihua Hao, Anqi Xia, Jiaying He, Song Xue, Christian T Mayer, Fan Wu, Bin Wang, Lunan Zhang, Lei Sun, Qiao Wang

Journal: Cell Rep

PubMed ID: 37178120

Doi: 10.1016/j.celrep.2023.112503

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Design and application of artificial rare L-lysine codons in Corynebacterium glutamicum

Authors: Cuiping Yang , Zehao Peng , Lu Yang , Bowen Du , Chuanzhuang Guo , Songsen Sui , Jianbin Wang , Junlin Li , Junqing Wang , Nan Li

Journal: Front Bioeng Biotechnol

PubMed ID: 7324439

Doi: 10.3389/fbioe.2023.1194511

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JNK3 Overexpression in the Entorhinal Cortex Impacts on the Hippocampus and Induces Cognitive Deficiencies and Tau Misfolding

Authors: Carlos G Ardanaz, Amaia Ezkurdia, Arantza Bejarano, Beatriz Echarte, Cristian Smerdou, Eva Martisova, Iván Martínez-Valbuena, María-Rosario Luquin, María J Ramírez, Maite Solas

Journal: ACS Chem Neurosci

PubMed ID: 37236204

Doi: 10.1021/acschemneuro.3c00092

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CLASPs stabilize the pre-catastrophe intermediate state between microtubule growth and shrinkage

Authors: Elizabeth J Lawrence, Saptarshi Chatterjee, Marija Zanic

Journal: J Cell Biol

PubMed ID: 37184584

Doi: 10.1083/jcb.202107027

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Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent

Authors: Xu Hou, Taylor Hsuan-Yu Chen, Shunsuke Koga, Jenny M Bredenberg, Ayman H Faroqi, Marion Delenclos, Guojun Bu, Zbigniew K Wszolek, Jonathan A Carr, Owen A Ross, Pamela J McLean, Melissa E Murray, Dennis W Dickson, Fabienne C Fiesel, Wolfdieter Springer

Journal: Brain Pathol

PubMed ID: 37259617

Doi: 10.1111/bpa.13175

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Single point mutations at the S129 residue of α-synuclein and their effect on structure, aggregation, and neurotoxicity

Authors: Esha Pandit, Lopamudra Das, Anoy Kumar Das, Sandip Dolui, Saumen Saha, Uttam Pal, Animesh Mondal, Joydeep Chowdhury, Subhas C Biswas, Nakul C Maiti

Journal: Front Chem

PubMed ID: 37304685

Doi: 10.3389/fchem.2023.1145877

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Massively parallel evaluation and computational prediction of the activities and specificities of 17 small Cas9s

Authors: Sang-Yeon Seo, Seonwoo Min, Sungtae Lee, Jung Hwa Seo, Jinman Park, Hui Kwon Kim, Myungjae Song, Dawoon Baek, Sung-Rae Cho, Hyongbum Henry Kim

Journal: Nat Methods

PubMed ID: 37188955

Doi: 10.1038/s41592-023-01875-2

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The effects of free Cys residues on the structure, activity, and tetrameric stability of mammalian uricase

Authors: Yong Guo, Jingjing Huo, Runchao Bai, Jingyuan Zhang, Jipeng Yao, Kaijie Ma, Zengtao Zhang, Haigang Li, Chun Zhang

Journal: Appl Microbiol Biotechnol

PubMed ID: 37256327

Doi: 10.1007/s00253-023-12597-y

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Functional characterization of novel or yet uncharacterized ATP7B missense variants detected in patients with clinical Wilson's disease

Authors: Amelie Stalke, Annika Behrendt, Finja Hennig, Holger Gohlke, Nicole Buhl, Thea Reinkens, Ulrich Baumann, Brigitte Schlegelberger, Thomas Illig, Eva-Doreen Pfister, Britta Skawran

Journal: Clin Genet

PubMed ID: 37157876

Doi: 10.1111/cge.14352

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Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases

Authors: Guangxue Liu, Jimin Li, Boxue He, Jiaqi Yan, Jingyu Zhao, Xuejie Wang, Xiaocong Zhao, Jingyan Xu, Yeyao Wu, Simin Zhang, Xiaoli Gan, Chun Zhou, Xiangpan Li, Xinghua Zhang, Xuefeng Chen

Journal: Nat Commun

PubMed ID: 37230987

Doi: 10.1038/s41467-023-38617-z

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Resin and loading condition screening for effective and robust byproducts removal by anion exchange chromatography: A case study

Authors: Wei Chen, Peter K Wang, Chien-Chun Liao, Yifeng Li, Yan Wan

Journal: Protein Expr Purif

PubMed ID: 37209930

Doi: 10.1016/j.pep.2023.106297

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Efficient precise integration of large DNA sequences with 3′-overhang dsDNA donors using CRISPR/Cas9

Authors: Wenjie Han, Zhigang Li, Yijun Guo, Kaining He, Wenqing Li, Caoling Xu, Lishuang Ge, Miao He, Xue Yin, Junxiang Zhou, Chengxu Li, Dongbao Yao, Jianqiang Bao, Haojun Liang

Journal: Proceedings of the national academy of sciences of the USA

PubMed ID: 37216515

Doi: 10.1073/pnas.2221127120

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Vesicular Stomatitis Virus (VSV) G Glycoprotein Can Be Modified to Create a Her2/Neu-Targeted VSV That Eliminates Large Implanted Mammary Tumors

Authors: Yanhua Gao, Ira Bergman

Journal: J Virol

PubMed ID: 37199666

Doi: 10.1128/jvi.00372-23

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Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage

Authors: James D Moody, Sarah Hill, Maike N Lundahl, Aubrianna J Saxton, Amanda Galambas, William E Broderick, C Martin Lawrence, Joan B Broderick

Journal: J Biol Chem

PubMed ID: 37156396

Doi: 10.1016/j.jbc.2023.104791

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Full-length versus truncated α-factor secretory signal sequences for expression of recombinant human insulin precursor in yeast Pichia pastoris: a comparison

Authors: Nuruliawaty Utami, Dini Nurdiani, Hariyatun Hariyatun, Eko Wahyu Putro, Fadillah Putri Patria, Wien Kusharyoto

Journal: J Genet Eng Biotechnol

PubMed ID: 37212962

Doi: 10.1186/s43141-023-00521-w

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A glycan receptor kinase facilitates intracellular accommodation of arbuscular mycorrhiza and symbiotic rhizobia in the legume Lotus japonicus

Authors: Simon Kelly, Simon B Hansen, Henriette Rübsam, Pia Saake, Emil B Pedersen, Kira Gysel, Eva Madland, Shunliang Wu, Stephan Wawra, Dugald Reid, John T Sullivan, Zuzana Blahovska, Maria Vinther, Artur Muszynski, Parastoo Azadi, Mikkel B Thygesen, Finn L Aachmann, Clive W Ronson, Alga Zuccaro, Kasper R Andersen, Simona Radutoiu, Jens Stougaard

Journal: PLoS Biol

PubMed ID: 37200394

Doi: 10.1371/journal.pbio.3002127

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Multiplexed Gene Engineering Based on dCas9 and gRNA-tRNA Array Encoded on Single Transcript

Authors: Chaoqian Jiang, Lishuang Geng, Jinpeng Wang, Yingjuan Liang, Xiaochen Guo, Chang Liu, Yunjing Zhao, Junxue Jin, Zhonghua Liu, Yanshuang Mu

Journal: Int J Mol Sci

PubMed ID: 37239880

Doi: 10.3390/ijms24108535

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Structural basis of epitope selectivity and potent protection from malaria by PfCSP antibody L9

Authors: Gregory M Martin, Monica L Fernández-Quintero, Wen-Hsin Lee, Tossapol Pholcharee, Lisa Eshun-Wilson, Klaus R Liedl, Marie Pancera, Robert A Seder, Ian A Wilson, Andrew B Ward

Journal: Nat Commun

PubMed ID: 37198165

Doi: 10.1038/s41467-023-38509-2

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