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Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in knock-out mammalian cells

Authors: Gábor Tax, Kevin P Guay, Tatiana Soldà, Charlie J Hitchman, Johan C Hill, Snežana Vasiljević, Andrea Lia, Carlos P Modenutti, Kees R Straatman, Angelo Santino, Maurizio Molinari, Nicole Zitzmann, Daniel N Hebert, Pietro Roversi, Marco Trerotola

Journal: biorxiv

PubMed ID: 37398215

Doi: 10.1101/2023.05.30.542711

Products & Services: Proteins, Expression, Isolation and Analysis

Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core

Authors: Pantelis Poumbourios, Christine Langer, Irene Boo, Tasnim Zakir, Rob J Center, Anouschka Akerman, Vanessa Milogiannakis, Anupriya Aggarwal, Bronte A Johnstone, Jungmin Ha, Fasséli Coulibaly, Stuart G Turville, Heidi E Drummer

Journal: PLoS Pathog

PubMed ID: 37200378

Doi: 10.1371/journal.ppat.1010981

Products & Services: Proteins, Expression, Isolation and Analysis

The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis

Authors: Jennilee M Davidson, Sharlynn S L Wu, Stephanie L Rayner, Flora Cheng, Kimberley Duncan, Carlo Russo, Michelle Newbery, Kunjie Ding, Natalie M Scherer, Rachelle Balez, Alberto García-Redondo, Alberto Rábano, Livia Rosa-Fernandes, Lezanne Ooi, Kelly L Williams, Marco Morsch, Ian P Blair, Antonio Di Ieva, Shu Yang, Roger S Chung, Albert Lee

Journal: Mol Neurobiol

PubMed ID: 37243816

Doi: 10.1007/s12035-023-03355-2

Products & Services: Proteins, Expression, Isolation and Analysis

saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity against SARS-CoV-2 variants of concern

Authors: Mai Komori, Takuto Nogimori, Amber L Morey, Takashi Sekida, Keiko Ishimoto, Matthew R Hassett, Yuji Masuta, Hirotaka Ode, Tomokazu Tamura, Rigel Suzuki, Jeff Alexander, Yasutoshi Kido, Kenta Matsuda, Takasuke Fukuhara, Yasumasa Iwatani, Takuya Yamamoto, Jonathan F Smith, Wataru Akahata

Journal: Nat Commun

PubMed ID: 37208330

Doi: 10.1038/s41467-023-38457-x

Products & Services: Proteins, Expression, Isolation and Analysis

Leveraging a Structural Blueprint to Rationally Engineer the Rieske Oxygenase TsaM

Authors: Jiayi Tian, Alejandro Arcadio Garcia, Patrick H Donnan, Jennifer Bridwell-Rabb

Journal: Biochemistry

PubMed ID: 37188334

Doi: 10.1021/acs.biochem.3c00150

Products & Services: Proteins, Expression, Isolation and Analysis

Antigen-Induced IL-1RA Production Discriminates Active and Latent Tuberculosis Infection

Authors: Cesar Sanchez, Luis Jaramillo-Valverde, Silvia Capristano, Gilmer Solis, Alonso Soto, Julio Valdivia-Silva, Julio A Poterico, Heinner Guio

Journal: Microorganisms

PubMed ID: 37374887

Doi: 10.3390/microorganisms11061385

Products & Services: Peptide Synthesis

Antibody blockade of Jagged1 attenuates choroidal neovascularization

Authors: Torleif Tollefsrud Gjølberg, Jonas Aakre Wik, Hanna Johannessen, Stig Krüger, Nicola Bassi, Panagiotis F Christopoulos, Malin Bern, Stian Foss, Goran Petrovski, Morten C Moe, Guttorm Haraldsen, Johanna Hol Fosse, Bjørn Steen Skålhegg, Jan Terje Andersen, Eirik Sundlisæter

Journal: Nat Commun

PubMed ID: 37253747

Doi: 10.1038/s41467-023-38563-w

Products & Services: Proteins, Expression, Isolation and Analysis

Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest

Authors: Bipul R Acharya, Jennifer S Fang, Erin D Jeffery, Nicholas W Chavkin, Gael Genet, Hema Vasavada, Elizabeth A Nelson, Gloria M Sheynkman, Martin J Humphries, Karen K Hirschi

Journal: Life Sci Alliance

PubMed ID: 37197981

Doi: 10.26508/lsa.202201685

Products & Services: Molecular Biology Reagents

Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant

Authors: Nanami Senoo, Dinesh K Chinthapalli, Matthew G Baile, Vinaya K Golla, Bodhisattwa Saha, Oluwaseun B Ogunbona, James A Saba, Teona Munteanu, Yllka Valdez, Kevin Whited, Dror Chorev, Nathan N Alder, Eric R May, Carol V Robinson, Steven M Claypool

Journal: biorxiv

PubMed ID: 37205478

Doi: 10.1101/2023.05.05.539595

Products & Services: Molecular Biology Reagents

Inflammation Modifies miR-21 Expression Within Neuronal Extracellular Vesicles to Regulate Remyelination Following Spinal Cord Injury

Authors: Tianyu Han, Peiwen Song, Zuomeng Wu, Yunlei Liu, Wang Ying, Cailiang Shen

Journal: Stem Cell Rev Rep

PubMed ID: 37256514

Doi: 10.1007/s12015-023-10560-y

Products & Services: Gene Synthesis

A highly efficient transgene knock-in technology in clinically relevant cell types

Authors: Alexander G Allen, Samia Q Khan, Carrie M Margulies, Ramya Viswanathan, Swarali Lele, Laura Blaha, Sean N Scott, Kaitlyn M Izzo, Alexandra Gerew, Rithu Pattali, Nadire R Cochran, Carl S Holland, Amy H Zhao, Stephen E Sherman, Michael C Jaskolka, Meng Wu, Aaron C Wilson, Xiaoqi Sun, Dawn M Ciulla, Deric Zhang, Jacqueline D Nelson, Peisheng Zhang, Patrizia Mazzucato, Yan Huang, Georgia Giannoukos, Eugenio Marco, Michael Nehil, John A Follit, Kai-Hsin Chang, Mark S Shearman, Christopher J Wilson, John A Zuris

Journal: Nat Biotechnol

PubMed ID: 37127662

Doi: 10.1038/s41587-023-01779-8

Products & Services: Gene Synthesis

Deep learning models to predict the editing efficiencies and outcomes of diverse base editors

Authors: Nahye Kim, Sungchul Choi, Sungjae Kim, Myungjae Song, Jung Hwa Seo, Seonwoo Min, Jinman Park, Sung-Rae Cho, Hyongbum Henry Kim

Journal: Nat Biotechnol

PubMed ID: 37188916

Doi: 10.1038/s41587-023-01792-x

Products & Services: Gene Synthesis

Structure of a 10-23 Deoxyribozyme Exhibiting a Homodimer Conformation

Authors: Evan Cramer, Sarah Starcovic, Rebekah Avey, Ali Kaya, Aaron Robart

Journal: Res Sq

PubMed ID: 37398199

Doi: 10.21203/rs.3.rs-2252941/v1

Products & Services: Gene Synthesis

Simultaneous enhancement of multiple functional properties using evolution-informed protein design

Authors: Benjamin Fram, Ian Truebridge, Yang Su, Adam J Riesselman, John B Ingraham, Alessandro Passera, Eve Napier, Nicole N Thadani, Samuel Lim, Kristen Roberts, Gurleen Kaur, Michael Stiffler, Debora S Marks, Christopher D Bahl, Amir R Khan, Chris Sander, Nicholas P Gauthier

Journal: biorxiv

PubMed ID: 37214973

Doi: 10.1101/2023.05.09.539914

Products & Services: Molecular Biology Reagents

Preparation of magnetic polyacrylamide hydrogel with chitosan for immobilization of glutamate decarboxylase to produce γ-aminobutyric acid

Authors: Jianjun Wang, Luyao Wang, Chengli Yang, Yihui Zhu, Ziqian Chen, Guanya He, Kaishun Hu, Kaixuan Liu, Beibei Fang, Dali Li, Ruofu Shi

Journal: Prep Biochem Biotechnol

PubMed ID: 37184437

Doi: 10.1080/10826068.2023.2209884

Products & Services: Proteins, Expression, Isolation and Analysis

Reticular adhesions are assembled at flat clathrin lattices and opposed by active integrin α5β1

Authors: Laura Hakanpää, Amr Abouelezz, An-Sofie Lenaerts, Seyda Culfa, Michael Algie, Jenny Bärlund, Pekka Katajisto, Harvey McMahon, Leonardo Almeida-Souza

Journal: J Cell Biol

PubMed ID: 37233325

Doi: 10.1083/jcb.202303107

Products & Services: Proteins, Expression, Isolation and Analysis

Arabidopsis calmodulin-like proteins CML13 and CML14 interact with proteins that have IQ domains

Authors: Howard J Teresinski, Bryan Hau, Kyle Symonds, Ryan Kilburn, Kim A Munro, Nathan M Doner, Robert Mullen, Vivian H Li, Wayne A Snedden

Journal: Plant Cell Environ

PubMed ID: 37222394

Doi: 10.1111/pce.14616

Products & Services: Catalog Antibody

Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants

Authors: Jianbo Wu, Zhenguo Chen, Yidan Gao, Zegen Wang, Jiarong Wang, Bing-Yu Chiang, Yunjiao Zhou, Yuru Han, Wuqiang Zhan, Minxiang Xie, Weiyu Jiang, Xiang Zhang, Aihua Hao, Anqi Xia, Jiaying He, Song Xue, Christian T Mayer, Fan Wu, Bin Wang, Lunan Zhang, Lei Sun, Qiao Wang

Journal: Cell Rep

PubMed ID: 37178120

Doi: 10.1016/j.celrep.2023.112503

Products & Services: Catalog Peptides

Design and application of artificial rare L-lysine codons in Corynebacterium glutamicum

Authors: Cuiping Yang , Zehao Peng , Lu Yang , Bowen Du , Chuanzhuang Guo , Songsen Sui , Jianbin Wang , Junlin Li , Junqing Wang , Nan Li

Journal: Front Bioeng Biotechnol

PubMed ID: 7324439

Doi: 10.3389/fbioe.2023.1194511

Products & Services: Gene Synthesis

JNK3 Overexpression in the Entorhinal Cortex Impacts on the Hippocampus and Induces Cognitive Deficiencies and Tau Misfolding

Authors: Carlos G Ardanaz, Amaia Ezkurdia, Arantza Bejarano, Beatriz Echarte, Cristian Smerdou, Eva Martisova, Iván Martínez-Valbuena, María-Rosario Luquin, María J Ramírez, Maite Solas

Journal: ACS Chem Neurosci

PubMed ID: 37236204

Doi: 10.1021/acschemneuro.3c00092

Products & Services: Proteins, Expression, Isolation and Analysis

CLASPs stabilize the pre-catastrophe intermediate state between microtubule growth and shrinkage

Authors: Elizabeth J Lawrence, Saptarshi Chatterjee, Marija Zanic

Journal: J Cell Biol

PubMed ID: 37184584

Doi: 10.1083/jcb.202107027

Products & Services: Proteins, Expression, Isolation and Analysis

Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent

Authors: Xu Hou, Taylor Hsuan-Yu Chen, Shunsuke Koga, Jenny M Bredenberg, Ayman H Faroqi, Marion Delenclos, Guojun Bu, Zbigniew K Wszolek, Jonathan A Carr, Owen A Ross, Pamela J McLean, Melissa E Murray, Dennis W Dickson, Fabienne C Fiesel, Wolfdieter Springer

Journal: Brain Pathol

PubMed ID: 37259617

Doi: 10.1111/bpa.13175

Products & Services: Proteins, Expression, Isolation and Analysis

Single point mutations at the S129 residue of α-synuclein and their effect on structure, aggregation, and neurotoxicity

Authors: Esha Pandit, Lopamudra Das, Anoy Kumar Das, Sandip Dolui, Saumen Saha, Uttam Pal, Animesh Mondal, Joydeep Chowdhury, Subhas C Biswas, Nakul C Maiti

Journal: Front Chem

PubMed ID: 37304685

Doi: 10.3389/fchem.2023.1145877

Products & Services: Proteins, Expression, Isolation and Analysis

Massively parallel evaluation and computational prediction of the activities and specificities of 17 small Cas9s

Authors: Sang-Yeon Seo, Seonwoo Min, Sungtae Lee, Jung Hwa Seo, Jinman Park, Hui Kwon Kim, Myungjae Song, Dawoon Baek, Sung-Rae Cho, Hyongbum Henry Kim

Journal: Nat Methods

PubMed ID: 37188955

Doi: 10.1038/s41592-023-01875-2

Products & Services: Molecular Biology Reagents

The effects of free Cys residues on the structure, activity, and tetrameric stability of mammalian uricase

Authors: Yong Guo, Jingjing Huo, Runchao Bai, Jingyuan Zhang, Jipeng Yao, Kaijie Ma, Zengtao Zhang, Haigang Li, Chun Zhang

Journal: Appl Microbiol Biotechnol

PubMed ID: 37256327

Doi: 10.1007/s00253-023-12597-y

Products & Services: Molecular Biology Reagents

An efficient transformation method for genome editing of elite bread wheat cultivars

Authors: Akshaya K Biswal, L Ruben B Hernandez, Ana I R Castillo, Juan M Debernardi, Kanwarpal S Dhugga

Journal: Front Plant Sci

PubMed ID: 37275249

Doi: 10.3389/fpls.2023.1135047

Products & Services: Custom DNA/RNA Oligos

L-Lactate treatment by photosynthetic cyanobacteria expressing heterogeneous L-lactate dehydrogenase

Authors: Yuichi Kato, Kosuke Inabe, Yuji Haraguchi, Tatsuya Shimizu, Akihiko Kondo, Tomohisa Hasunuma

Journal: Sci Rep

PubMed ID: 37142758

Doi: 10.1038/s41598-023-34289-3

Products & Services: Gene Synthesis

Vesicular Stomatitis Virus (VSV) G Glycoprotein Can Be Modified to Create a Her2/Neu-Targeted VSV That Eliminates Large Implanted Mammary Tumors

Authors: Yanhua Gao, Ira Bergman

Journal: J Virol

PubMed ID: 37199666

Doi: 10.1128/jvi.00372-23

Products & Services: Proteins, Expression, Isolation and Analysis

Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage

Authors: James D Moody, Sarah Hill, Maike N Lundahl, Aubrianna J Saxton, Amanda Galambas, William E Broderick, C Martin Lawrence, Joan B Broderick

Journal: J Biol Chem

PubMed ID: 37156396

Doi: 10.1016/j.jbc.2023.104791

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of a Transmembrane Protein Involved in Shear Stress Signaling and Hepatocarcinogenesis After a Sustained Virological Response to Hepatitis C Virus

Authors: Masashi Nishikawa, Hikari Okada, Kazunori Kawaguchi, Tetsuro Shimakami, Kouki Nio, Kuniaki Arai, Tatsuya Yamashita, Motoko Sasaki, Shuichi Kaneko, Taro Yamashita, Masao Honda

Journal: Cell Mol Gastroenterol Hepatol

PubMed ID: 37146715

Doi: 10.1016/j.jcmgh.2023.04.006

Products & Services: Proteins, Expression, Isolation and Analysis

Modular Hydrogel Vaccine for Programmable and Coordinate Elicitation of Cancer Immunotherapy

Authors: Panpan Ji, Wenqi Sun, Siyan Zhang, Yuqi Xing, Chen Wang, Mengying Wei, Qiuyun Li, Gang Ji, Guodong Yang

Journal: Adv Sci (Weinh)

PubMed ID: 37222047

Doi: 10.1002/advs.202301789

Products & Services: Proteins, Expression, Isolation and Analysis

The free-living flagellate Paratrimastix pyriformis uses a distinct mitochondrial carrier to balance adenine nucleotide pools

Authors: Justyna Zítek, Martin S King, Priscila Peña-Diaz, Eva Pyrihová, Alannah C King, Edmund R S Kunji, Vladimír Hampl

Journal: Arch Biochem Biophys

PubMed ID: 37192692

Doi: 10.1016/j.abb.2023.109638

Products & Services: Proteins, Expression, Isolation and Analysis

Multiplexed Gene Engineering Based on dCas9 and gRNA-tRNA Array Encoded on Single Transcript

Authors: Chaoqian Jiang, Lishuang Geng, Jinpeng Wang, Yingjuan Liang, Xiaochen Guo, Chang Liu, Yunjing Zhao, Junxue Jin, Zhonghua Liu, Yanshuang Mu

Journal: Int J Mol Sci

PubMed ID: 37239880

Doi: 10.3390/ijms24108535

Products & Services: Proteins, Expression, Isolation and Analysis

Functional characterization of novel or yet uncharacterized ATP7B missense variants detected in patients with clinical Wilson's disease

Authors: Amelie Stalke, Annika Behrendt, Finja Hennig, Holger Gohlke, Nicole Buhl, Thea Reinkens, Ulrich Baumann, Brigitte Schlegelberger, Thomas Illig, Eva-Doreen Pfister, Britta Skawran

Journal: Clin Genet

PubMed ID: 37157876

Doi: 10.1111/cge.14352

Products & Services: Gene Synthesis

Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases

Authors: Guangxue Liu, Jimin Li, Boxue He, Jiaqi Yan, Jingyu Zhao, Xuejie Wang, Xiaocong Zhao, Jingyan Xu, Yeyao Wu, Simin Zhang, Xiaoli Gan, Chun Zhou, Xiangpan Li, Xinghua Zhang, Xuefeng Chen

Journal: Nat Commun

PubMed ID: 37230987

Doi: 10.1038/s41467-023-38617-z

Products & Services: Recombinant Proteins

Antimicrobial activity of the Flo peptide produced in Scenedesmus acutus and Nannochloropsis oculata

Authors: Saraí Damaris Dávalos-Guzmán, Fidel Martinez-Gutierrez, Luzmila Martínez-González, Jesús Josafath Quezada-Rivera, Ana Cecilia Lorenzo-Leal, Horacio Bach, José Francisco Morales-Domínguez, Ruth Elena Soria-Guerra

Journal: World J Microbiol Biotechnol

PubMed ID: 37249711

Doi: 10.1007/s11274-023-03664-7

Products & Services: Gene Synthesis

Circ_0069094 regulates malignant phenotype and paclitaxel resistance in breast cancer cells via targeting the miR-136-5p/YWHAZ axis

Authors: Zhihua Kong, Qi Han, Bisheng Zhu, Long Wan, Enrong Feng

Journal: Thorac Cancer

PubMed ID: 37192740

Doi: 10.1111/1759-7714.14928

Products & Services: Custom RNAi Services

Resin and loading condition screening for effective and robust byproducts removal by anion exchange chromatography: A case study

Authors: Wei Chen, Peter K Wang, Chien-Chun Liao, Yifeng Li, Yan Wan

Journal: Protein Expr Purif

PubMed ID: 37209930

Doi: 10.1016/j.pep.2023.106297

Products & Services: Proteins, Expression, Isolation and Analysis

Efficient precise integration of large DNA sequences with 3′-overhang dsDNA donors using CRISPR/Cas9

Authors: Wenjie Han, Zhigang Li, Yijun Guo, Kaining He, Wenqing Li, Caoling Xu, Lishuang Ge, Miao He, Xue Yin, Junxiang Zhou, Chengxu Li, Dongbao Yao, Jianqiang Bao, Haojun Liang

Journal: Proceedings of the national academy of sciences of the USA

PubMed ID: 37216515

Doi: 10.1073/pnas.2221127120

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Full-length versus truncated α-factor secretory signal sequences for expression of recombinant human insulin precursor in yeast Pichia pastoris: a comparison

Authors: Nuruliawaty Utami, Dini Nurdiani, Hariyatun Hariyatun, Eko Wahyu Putro, Fadillah Putri Patria, Wien Kusharyoto

Journal: J Genet Eng Biotechnol

PubMed ID: 37212962

Doi: 10.1186/s43141-023-00521-w

Products & Services: Proteins, Expression, Isolation and Analysis

A glycan receptor kinase facilitates intracellular accommodation of arbuscular mycorrhiza and symbiotic rhizobia in the legume Lotus japonicus

Authors: Simon Kelly, Simon B Hansen, Henriette Rübsam, Pia Saake, Emil B Pedersen, Kira Gysel, Eva Madland, Shunliang Wu, Stephan Wawra, Dugald Reid, John T Sullivan, Zuzana Blahovska, Maria Vinther, Artur Muszynski, Parastoo Azadi, Mikkel B Thygesen, Finn L Aachmann, Clive W Ronson, Alga Zuccaro, Kasper R Andersen, Simona Radutoiu, Jens Stougaard

Journal: PLoS Biol

PubMed ID: 37200394

Doi: 10.1371/journal.pbio.3002127

Products & Services: Proteins, Expression, Isolation and Analysis

The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms

Authors: Duy Lan Huong Bui, Andrew Roach, Jingxian Li, Sumit J Bandekar, Elizabeth Orput, Ritika Raghavan, Demet Araç, Richard C Sando

Journal: Cell Rep

PubMed ID: 37224017

Doi: 10.1016/j.celrep.2023.112552

Products & Services: Molecular Biology Reagents

Structural basis of epitope selectivity and potent protection from malaria by PfCSP antibody L9

Authors: Gregory M Martin, Monica L Fernández-Quintero, Wen-Hsin Lee, Tossapol Pholcharee, Lisa Eshun-Wilson, Klaus R Liedl, Marie Pancera, Robert A Seder, Ian A Wilson, Andrew B Ward

Journal: Nat Commun

PubMed ID: 37198165

Doi: 10.1038/s41467-023-38509-2

Products & Services: Codon Optimization

A rapidly evolving single copy histone H1 variant is associated with male fertility in a parasitoid wasp

Authors: Bo Yuan, Yi Yang, Zhichao Yan, Chun He, Yu H Sun, Fei Wang, Beibei Wang, Jiamin Shi, Shan Xiao, Fang Wang, Qi Fang, Fei Li, Xinhai Ye, Gongyin Ye

Journal: Front Cell Dev Biol

PubMed ID: 37325562

Doi: 10.3389/fcell.2023.1166517

Products & Services: Monoclonal Antibody Services

Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing

Authors: Christopher C Pan, Raquel Maeso-Díaz, Tylor R Lewis, Kun Xiang, Lianmei Tan, Yaosi Liang, Liuyang Wang, Fengrui Yang, Tao Yin, Calvin Wang, Kuo Du, De Huang, Seh Hoon Oh, Ergang Wang, Bryan Jian Wei Lim, Mengyang Chong, Peter B Alexander, Xuebiao Yao, Vadim Y Arshavsky, Qi-Jing Li, Anna Mae Diehl, Xiao-Fan Wang

Journal: Cell Res

PubMed ID: 37169907

Doi: 10.1038/s41422-023-00820-4

Products & Services: PCR Cloning and Subcloning

Improved biosynthesis of heme in Bacillus subtilis through metabolic engineering assisted fed-batch fermentation

Authors: Shaomei Yang, Anlong Wang, Jiachang Li, Yunhang Shao, Fengjie Sun, Shucheng Li, Kai Cao, Hongliang Liu, Peng Xiong, Zhengquan Gao

Journal: Microb Cell Fact

PubMed ID: 37198628

Doi: 10.1186/s12934-023-02077-3

Products & Services: Gene Synthesis

Transcriptome Analysis and Identification of Sesquiterpene Synthases in Liverwort Jungermannia exsertifolia

Authors: Xiaoguang Yan, Yukun Li, Weiguo Li, Dongmei Liang, Shengxin Nie, Ruiqi Chen, Jianjun Qiao, Mingzhang Wen, Qinggele Caiyin

Journal: Bioengineering (Basel) .

PubMed ID: 37237639

Doi: 10.3390/bioengineering10050569

Products & Services: Proteins, Expression, Isolation and Analysis

Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes

Authors: Jonathan D Teo , Oana C Marian , Alanna G Spiteri , Madeline Nicholson , Huitong Song , Jasmine X Y Khor , Holly P McEwen , Anjie Ge , Monokesh K Sen , Laura Piccio , Jessica L Fletcher , Nicholas J C King , Simon S Murray , Jens C Brüning , Anthony S Don

Journal: Glia .

PubMed ID: 36583573

Doi: 10.1002/glia.24329

Products & Services: Recombinant Proteins

A molecular study on recombinant pullulanase type I from Metabacillus indicus.

Authors: Zahraa Z Al-Mamoori , Amira M Embaby , Ahmed Hussein , Hoda E Mahmoud

Journal: AMB Express

PubMed ID: 37119334

Doi: 10.1186/s13568-023-01545-8.

Products & Services: Gene Synthesis

Adjuvant-Free COVID-19 Vaccine with Glycoprotein Antigen Oxidized by Periodate Rapidly Elicits Potent Immune Responses

Authors: Ru-Yan Zhang, Shi-Hao Zhou, Ran-Ran Feng, Yu Wen, Dong Ding, Zhi-Ming Zhang, Hua-Wei Wei, Jun Guo

Journal: ACS Chemical Biology

PubMed ID: 37009726

Doi: 10.1021/acschembio.3c00050

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LvCD14L Acts as a Novel Pattern Recognition Receptor and a Regulator of the Toll Signaling Pathway in Shrimp

Authors: Xinjia Lv, Shihao Li 1,2,3, Yang Yu, Songjun Jin, Xiaojun Zhang, Fuhua Li

Journal: International Journal of Molecular Sciences

Doi: 10.3390/ijms24097770

Products & Services: Proteins, Expression, Isolation and Analysis eBlot™ L1 Fast Wet Transfer System

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

Authors: Dongchun Ni, Priscilla Turelli, Bertrand Beckert, Sergey Nazarov, Emiko Uchikawa, Alexander Myasnikov, Florence Pojer, Didier Trono, Henning Stahlberg, Kelvin Lau

Journal: PLoS pathogens

PubMed ID: 37018380

Doi: 10.1371/journal.ppat.1011206

Products & Services: Gene Synthesis

Knockdown of the salivary protein gene NlG14 caused displacement of the lateral oviduct secreted components and inhibited ovulation in Nilaparvata lugens

Authors: Haoli Gao, Huihui Zhang, Xiaowei Yuan, Xumin Lin, Jianzheng Zou, Na Yu, Zewen Liu

Journal: PLOS Genetics

PubMed ID: 37011098

Doi: 10.1371/journal.pgen.1010704

Products & Services: Proteins, Expression, Isolation and Analysis

Precise integration of large DNA sequences in plant genomes using PrimeRoot editors

Authors: Chao Sun, Yuan Lei, Boshu Li, Qiang Gao, Yunjia Li, Wen Cao, Chao Yang, Hongchao Li, Zhiwei Wang, Yan Li, Yanpeng Wang, Jun Liu, Kevin Tianmeng Zhao, Caixia Gao

Journal: Nature Biotechnology

PubMed ID: 37095350

Doi: 10.1038/s41587-023-01769-w

Products & Services: Gene Synthesis

Protein Delivery to Insect Epithelial Cells In Vivo: Potential Application to Functional Molecular Analysis of Proteins in Butterfly Wing Development

Authors: Yugo Nakazato, Joji M Otaki

Journal: BioTech (Basel)

PubMed ID: 37092472

Doi: 10.3390/biotech12020028

Products & Services: Molecular Biology Reagents

Is Penguin Circovirus Circulating Only in the Antarctic Circle? Lack of Viral Detection in Namibia

Authors: Laura C Roberts, Umberto Molini, Lauren M Coetzee, Siegfried Khaiseb, Jean-Paul Roux, Jessica Kemper, David G Roberts, Katrin Ludynia, Marcus Doherr, Darrell Abernethy, Giovanni Franzo

Journal: Animals (Basel)

PubMed ID: 37174486

Doi: 10.3390/ani13091449

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Novel targeting assay uncovers targeting information within peroxisomal ABC transporter Pxa1

Authors: Renate L M Jansen, Marco van den Noort, Arjen M Krikken, Chen Bibi, Astrid Böhm, Maya Schuldiner, Einat Zalckvar, Ida J van der Klei

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 37028652

Doi: 10.1016/j.bbamcr.2023.119471

Products & Services: Plasmid DNA Preparation

A novel anti-membrane CD30 single-chain variable fragment discovered from the human phage library: A potential targeted immunotherapy

Authors: Thanida Chanpong, Watee Seesuay, Wararat Chiangjong, Piamsiri Jiramornimit, Sarinthip Preedagasamzin, Korakot Atjanasuppat, Bunyada Jittorntrum, Somsak Prasongtanakij, Supannikar Tawinwung, Sulada Pukiat, Chonticha Saisawang, Suparerk Borwornpinyo, Khanit Sa-Ngiamsuntorn, Wanpen Chaichumpa, Suradej Hongeng, Usanarat Anurathapan

Journal: PLoS ONE

PubMed ID: 37079526

Doi: 10.1371/journal.pone.0284708

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FTO promotes cervical cancer cell proliferation, colony formation, migration and invasion via the regulation of the BMP4/Hippo/YAP1/TAZ pathway

Authors: Jinyuan Huang, Jing Yang, Yudi Zhang, Dan Lu, Yinmei Dai

Journal: Exp Cell Res

PubMed ID: 37030332

Doi: 10.1016/j.yexcr.2023.113585

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Chemical shift assignments of calmodulin bound to a cytosolic domain of GluN2A (residues 1004-1024) from the NMDA receptor

Authors: Aritra Bej, James B Ames

Journal: Biomol NMR Assign

PubMed ID: 37029330

Doi: 10.1007/s12104-023-10125-7

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Constitutively activated AMPKα1 protects against skeletal aging in mice by promoting bone-derived IGF-1 secretion

Authors: Yiqi Yang, Kai Yuan, Yihao Liu, Qishan Wang, Yixuan Lin, Shengbing Yang, Kai Huang, Tianyou Kan, Yuxin Zhang, Mingming Xu, Zhifeng Yu, Qiming Fan, Yugang Wang, Hanjun Li, Tingting Tang

Journal: Cell Prolif

PubMed ID: 37042047

Doi: 10.1111/cpr.13476

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ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience

Authors: Natalia Jiménez-Moreno, Madhu Kollareddy, Petros Stathakos, Joanna J Moss, Zuriñe Antón, Deborah K Shoemark, Richard B Sessions, Ralph Witzgall, Maeve Caldwell, Jon D Lane

Journal: J Cell Biol

PubMed ID: 37014324

Doi: 10.1083/jcb.201910133

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Tuning the immune response: sulfated archaeal glycolipid archaeosomes as an effective vaccine adjuvant for induction of humoral and cell-mediated immunity towards the SARS-CoV-2 Omicron variant of concern

Authors: Tyler M Renner, Bassel Akache, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates, Lise Deschatelets, Renu Dudani, Blair A Harrison, Jason Baardsnes, Izel Koyuturk, Jennifer J Hill, Usha D Hemraz, Sophie Régnier, Anne E G Lenferink, Yves Durocher, Michael J McCluskie

Journal: Frontiers in Immunology

PubMed ID: 37122746

Doi: 10.3389/fimmu.2023.1182556

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Baseline corticosterone levels in spadefoot toads reflect alternate larval diets one year later

Authors: Cristina C Ledón-Rettig, Katie M Lo, Sarah R Lagon

Journal: Gen Comp Endocrinol

PubMed ID: 37094616

Doi: 10.1016/j.ygcen.2023.114291

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CD95/Fas ligand mRNA is toxic to cells through more than one mechanism

Authors: Ashley Haluck-Kangas, Madelaine Fink, Elizabeth T Bartom, Marcus E Peter

Journal: Mol Biomed

PubMed ID: 37059938

Doi: 10.1186/s43556-023-00119-1

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Single particle cryo-EM analysis of Rickettsia conorii Sca2 reveals a formin-like core

Authors: Peter J Carman, Grzegorz Rebowski, Roberto Dominguez, Saif S Alqassim

Journal: J Struct Biol

PubMed ID: 37028467

Doi: 10.1016/j.jsb.2023.107960

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High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo

Authors: Sebastian G Huayamares, Melissa P Lokugamage, Regina Rab, Alejandro J Da Silva Sanchez, Hyejin Kim, Afsane Radmand, David Loughrey, Liming Lian, Yuning Hou, Bhagelu R Achyut, Annette Ehrhardt, Jeong S Hong, Cory D Sago, Kalina Paunovska, Elisa Schrader Echeverri, Daryll Vanover, Philip J Santangelo, Eric J Sorscher, James E Dahlman

Journal: J Control Release

PubMed ID: 37028451

Doi: 10.1016/j.jconrel.2023.04.005

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Production of Clubroot Standards Using a Recombinant Surrogate to Overcome Natural Genetic Variability

Authors: Anjana Patel, Roy Kennedy

Journal: Plants (Basel)

PubMed ID: 37111913

Doi: 10.3390/plants12081690

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Shieldin complex assembly kinetics and DNA binding by SHLD3

Authors: Vivek Susvirkar, Alex C Faesen

Journal: Commun Biol

PubMed ID: 37031298

Doi: 10.1038/s42003-023-04757-7

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Development and evaluation of an indirect ELISA using a multiepitope antigen for the diagnosis of intestinal schistosomiasis

Authors: Karine Ferreira Lopes, Mariana Lourenço Freire, Dayane Costa Souza Lima, Martin Johannes Enk, Edward Oliveira, Stefan Michael Geiger

Journal: Parasitology

PubMed ID: 37092694

Doi: 10.1017/S0031182023000409

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Mycobacterium tuberculosis-Specific CD4 T Cells Expressing Transcription Factors T-Bet or RORγT Associate with Bacterial Control in Granulomas

Authors: Nicole L Grant, Kristen Kelly, Pauline Maiello, Helena Abbott, Shelby O'Connor, Philana Ling Lin, Charles A Scanga, JoAnne L Flynn

Journal: MBio

PubMed ID: 37039646

Doi: 10.1128/mbio.00477-23

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Interspecies/Intergroup Complementation of Orthotospovirus Replication and Movement through Reverse Genetics Systems

Authors: Mingfeng Feng, Minglong Chen, Yulong Yuan, Qinhai Liu, Ruixiang Cheng, Tongqing Yang, Luyao Li, Rong Guo, Yongxin Dong, Jing Chen, Yawen Yang, Yuling Yan, Hongmin Cui, Dong Jing, Jinrui Kang, Shuxian Chen, Jia Li, Min Zhu, Changjun Huang, Zhongkai Zhang, Richard Kormelink, Xiaorong Tao

Journal: J Virol

PubMed ID: 37022194

Doi: 10.1128/jvi.01809-22

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Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway

Authors: Alexander D Fulford, Leonie Enderle, Jannette Rusch, Didier Hodzic, Maxine V Holder, Alex Earl, Robin Hyunseo Oh, Nicolas Tapon, Helen McNeill

Journal: J Cell Biol

PubMed ID: 37071483

Doi: 10.1083/jcb.202204059

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Proteomic analysis of extracellular vesicles from tick hemolymph and uptake of extracellular vesicles by salivary glands and ovary cells

Authors: Zhengmao Xu, Yanan Wang, Meng Sun, Yongzhi Zhou, Jie Cao, Houshuang Zhang, Xuenan Xuan, Jinlin Zhou

Journal: Parasit Vectors

PubMed ID: 37046327

Doi: 10.1186/s13071-023-05753-w

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Low-grade glioma risk SNP rs11706832 is associated with type I interferon response pathway genes in cell lines

Authors: Adam Rosenbaum, Anna M Dahlin, Ulrika Andersson, Benny Björkblom, Wendy Yi-Ying Wu, Håkan Hedman, Carl Wibom, Beatrice Melin

Journal: Sci Rep

PubMed ID: 37185361

Doi: 10.1038/s41598-023-33923-4

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Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases

Authors: Iris D Zelnik, Beatriz Mestre, Jonathan J Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel J Fleishman, Anthony H Futerman

Journal: Nat Commun

PubMed ID: 37087500

Doi: 10.1038/s41467-023-38047-x

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A Recombinant Chimeric Cedar Virus-Based Surrogate Neutralization Assay Platform for Pathogenic Henipaviruses

Authors: Moushimi Amaya, Randy Yin, Lianying Yan, Viktoriya Borisevich, Bishwo N Adhikari, Andrew Bennett, Francisco Malagon, Regina Z Cer, Kimberly A Bishop-Lilly, Antony S Dimitrov, Robert W Cross, Thomas W Geisbert, Christopher C Broder

Journal: Viruses

PubMed ID: 37243163

Doi: 10.3390/v15051077

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A triple amplification strategy using GR-5 DNAzyme as a signal medium for ultrasensitive detection of trace Pb based on CRISPR/Cas12a empowered electrochemical biosensor

Authors: Yuanyuan Yue, Songtao Wang, Qiang Jin, Nan An, Lina Wu, He Huang

Journal: Anal Chim Acta

PubMed ID: 37225346

Doi: 10.1016/j.aca.2023.341241

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Modulatory role of copper on hIAPP aggregation and toxicity in presence of insulin

Authors: Dipanwita Roy, Narayan Chandra Maity, Sourav Kumar, Anupam Maity, Bhisma N Ratha, Ranjit Biswas, Nakul Chandra Maiti, Atin Kumar Mandal, Anirban Bhunia

Journal: Int J Biol Macromol

PubMed ID: 37088193

Doi: 10.1016/j.ijbiomac.2023.124470

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Endoplasmic reticulum chaperone GRP78 participates in fluoride-induced autophagy in LS8 cells by regulating the IRE1-TRAF2-JNK pathway

Authors: Lin Zhao, Liyuan Wang, Han Wang, Tao Xi, Sijia Liu, Yang Li, Jianping Ruan, Yongqing Huang

Journal: Environ Toxicol

PubMed ID: 37070943

Doi: 10.1002/tox.23805

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Structural basis of impaired disaggregase function in the oxidation-sensitive SKD3 mutant causing 3-methylglutaconic aciduria

Authors: Sukyeong Lee, Sang Bum Lee, Nuri Sung, Wendy W Xu, Changsoo Chang, Hyun-Eui Kim, Andre Catic, Francis T F Tsai

Journal: Nat Commun

PubMed ID: 37041140

Doi: 10.1038/s41467-023-37657-9

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Immunological characterization of a VIR protein family member (VIR-14) in Plasmodium vivax-infected subjects from different epidemiological regions in Africa and South America

Authors: Raianna F Fantin, Camila H Coelho, Anne D Berhe, Luisa M D Magalhães, Dhélio B Pereira, Nichole D Salinas, Niraj H Tolia, Chanaki Amaratunga, Seila Suon, Issaka Sagara, David L Narum, Ricardo T Fujiwara, Claudia Abejon, Antonio Campos-Neto, Patrick E Duffy, Lilian L Bueno

Journal: PLoS Negl Trop Dis

PubMed ID: 37027391

Doi: 10.1371/journal.pntd.0011229

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Interaction of LARP4 to filamin A mechanosensing domain regulates cell migrations

Authors: Zhenfeng Mao, Fumihiko Nakamura

Journal: Front Cell Dev Biol

PubMed ID: 37169020

Doi: 10.3389/fcell.2023.1152109

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Organization, genomic targeting, and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis

Authors: Wei Fu, Yaoguang Yu, Jie Shu , Zewang Yu, Yixiong Zhong, Tao Zhu, Zhihao Zhang, Zhenwei Liang, Yuhai Cui, Chen Chen , Chenlong Li

Journal: Plant Cell .

PubMed ID: 37062961

Doi: 10.1093/plcell/koad111

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Codon pair bias deoptimization of essential genes in infectious laryngotracheitis virus reduces protein expression

Authors: Paola K Vaz, Marzieh Armat, Carol A Hartley, Joanne M Devlin

Journal: J Gen Virol

PubMed ID: 37010948

Doi: 10.1099/jgv.0.001836

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COVID-19 adenovirus vector vaccine induces higher interferon and pro-inflammatory responses than mRNA vaccines in human PBMCs, macrophages and moDCs

Authors: Miao Jiang, Elina Väisänen, Pekka Kolehmainen, Moona Huttunen, Seppo Ylä-Herttuala, Seppo Meri, Pamela Österlund, Ilkka Julkunen

Journal: Vaccine

PubMed ID: 37142461

Doi: 10.1016/j.vaccine.2023.04.049

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Clinical Validation of a Colorimetric Loop-Mediated Isothermal Amplification Using a Portable Device for the Rapid Detection of SARS-CoV-2

Authors: Bruna W Raddatz, Felipe J Rabello, Rafael Benedetti, Gisleine J Steil, Louise M Imamura, Edson Y S Kim, Erika B Santiago, Luís F Hartmann, João V Predebon, Bruna M Delfino, Meri B Nogueira, Jucélia S Dos Santos, Breno G da Silva, Diego R P Nicollete, Bernardo M M de Almeida, Sergio R Rogal, Marcus V M Figueredo

Journal: Diagnostics (Basel)

PubMed ID: 37046573

Doi: 10.3390/diagnostics13071355

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Sub-millisecond conformational dynamics of the A adenosine receptor revealed by single-molecule FRET

Authors: Ivan Maslov, Oleksandr Volkov, Polina Khorn, Philipp Orekhov, Anastasiia Gusach, Pavel Kuzmichev, Andrey Gerasimov, Aleksandra Luginina, Quinten Coucke, Andrey Bogorodskiy, Valentin Gordeliy, Simon Wanninger, Anders Barth, Alexey Mishin, Johan Hofkens, Vadim Cherezov, Thomas Gensch, Jelle Hendrix, Valentin Borshchevskiy

Journal: Commun Biol

PubMed ID: 37012383

Doi: 10.1038/s42003-023-04727-z

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Modular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responses

Authors: Audrey Kassardjian, Eric Sun, Jamie Sookhoo, Krithika Muthuraman, Kayluz Frias Boligan, Iga Kucharska, Edurne Rujas, Arif Jetha, Donald R Branch, Shawn Babiuk, Brian Barber, Jean-Philippe Julien

Journal: Cell Rep

PubMed ID: 37053069

Doi: 10.1016/j.celrep.2023.112391

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SLFN5-mediated chromatin dynamics sculpt higherorder DNA repair topology

Authors: Jinzhou Huang, Chenming Wu, Jake A Kloeber, Huanyao Gao, Ming Gao, Qian Zhu, Yiming Chang, Fei Zhao, Guijie Guo, Kuntian Luo, Haiming Dai, Sijia Liu, Qiru Huang, Wootae Kim, Qin Zhou, Shouhai Zhu, Zheming Wu, Xinyi Tu, Ping Yin, Min Deng, Liewei Wang, Jian Yuan, Zhenkun Lou

Journal: molecular cell

PubMed ID: 36854302

Doi: 10.1016/j.molcel.2023.02.004

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Multifunctional activity-based chemical probes for sirtuins

Authors: Chiranjeev Sharma, Dickson Donu, Alyson M Curry, Elizabeth Barton, Yana Cen

Journal: RSC Adv

PubMed ID: 37063743

Doi: 10.1039/d3ra02133e

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Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization

Authors: Mallika Sastry, Anita Changela, Jason Gorman, Kai Xu, Gwo-Yu Chuang, Chen-Hsiang Shen, Cheng Cheng, Hui Geng, Sijy O'Dell, Li Ou, Reda Rawi, Mateo Reveiz, Guillaume B E Stewart-Jones, Shuishu Wang, Baoshan Zhang, Tongqing Zhou, Andrea Biju, Michael Chambers, Xuejun Chen, Angela R Corrigan, Bob C Lin, Mark K Louder, Krisha McKee, Alexandra F Nazzari, Adam S Olia, Danealle K Parchment, Edward K Sarfo, Tyler Stephens, Jonathan Stuckey, Yaroslav Tsybovsky, Raffaello Verardi, Yiran Wang, Cheng-Yan Zheng, Yuling Chen, Nicole A Doria-Rose, Adrian B McDermott, John R Mascola, Peter D Kwong

Journal: J Virol

PubMed ID: 37098956

Doi: 10.1128/jvi.01604-22

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H, N, C backbone and Cβ resonance assignments for UBQLN1 UBA and UBAA domains

Authors: Gwen R Buel, Xiang Chen, Olumide Kayode, Anthony Cruz, Kylie J Walters

Journal: Biomol NMR Assign

PubMed ID: 37022617

Doi: 10.1007/s12104-023-10127-5

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Enhanced Degradation of Mutant -Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and Neuroprotection

Authors: Allison S Vanecek, Jelena Mojsilovic-Petrovic, Robert G Kalb, Jetze J Tepe

Journal: ACS Chem Neurosci

PubMed ID: 37015082

Doi: 10.1021/acschemneuro.2c00732

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Salt stress-induced chloroplastic hydrogen peroxide stimulates pdTPI sulfenylation and methylglyoxal accumulation

Authors: Zheng-Wei Fu, Yu-Rui Feng, Xiang Gao, Feng Ding, Jian-Hui Li, Ting-Ting Yuan, Ying-Tang Lu

Journal: Plant Cell

PubMed ID: 36695476

Doi: 10.1093/plcell/koad019

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Direct Virus Gene Detection: A CRISPR/dCas9-Mediated Surface- Enhanced Raman Scattering Strategy with Enzyme-Catalyzed Signal Amplification

Authors: Ailing Su , Yuan Liu , Xiumian Cao , Junyi Zhao , Weiqing Xu , Chongyang Liang , Ping Li , Shuping Xu

Journal: Anal Chem .

PubMed ID: 36995921

Doi: 10.1021/acs.analchem.2c05384

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Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults

Authors: Chanchan Xiao, Zhiyao Ren , Bei Zhang , Lipeng Mao , Guodong Zhu , Lijuan Gao , Jun Su , Jiezhou Ye , Ze Long , Yue Zhu , Pengfei Chen , Xiangmeng Su , Tong Zhou , Yanhao Huang , Xiongfei Chen , Chaojun Xie , Jun Yuan , Yutian Hu , Jingshan Zheng , Zhigang Wang , Jianrong Lou , Xiang Yang , Zhiqiang Kuang , Hongyi Zhang , Pengcheng Wang , Xiaofeng Liang , Oscar Junhong Luo , Guobing Chen

Journal: Nat Aging .

PubMed ID: 37117789

Doi: 10.1038/s43587-023-00379-0

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Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling

Authors: Ikuo Masuho , Nickolas K Skamangas , Brian S Muntean , Kirill A Martemyanov

Journal: Cell Syst .

PubMed ID: 33667409

Doi: 10.1016/j.cels.2021.02.001

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Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking

Authors: Dongxue Wang, Yunjin Yao, Shiqi Wang, Yifei Hou, Lanxue Zhao, Hao Wang, Hongzhuan Chen, Jianrong Xu