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Kinetic and Structural Characterization of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors

Authors: Kayla Glockzin, Kathleen M Meneely, Ryan Hughes, Sean W Maatouk, Grace E Piña, Kajitha Suthagar, Keith Clinch, Joshua N Buckler, Audrey L Lamb, Peter C Tyler, Thomas D Meek, Ardala Katzfuss

Journal: Biochemistry

PubMed ID: 37418678

Doi: 10.1021/acs.biochem.3c00116

Products & Services: Proteins, Expression, Isolation and Analysis

Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity

Authors: Ian N Boys, Alex G Johnson, Meghan R Quinlan, Philip J Kranzusch, Nels C Elde

Journal: Cell Rep

PubMed ID: 37494187

Doi: 10.1016/j.celrep.2023.112878

Products & Services: Molecular Biology Reagents

Computationally Designed Small Molecules Disassemble Both Soluble Oligomers and Protofibrils of Amyloid β-Protein Responsible for Alzheimer's Disease

Authors: Yingying Jin, Matthew A Downey, Ambuj Singh, Steven K Buratto, Michael T Bowers

Journal: ACS Chem Neurosci

PubMed ID: 37442126

Doi: 10.1021/acschemneuro.3c00266

Products & Services: Proteins, Expression, Isolation and Analysis

Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues

Authors: Yorick Post, Archana Dilip, Liqin Xie, Asmiti Sura, Nicholas Suen, Jay Ye, Devin Mutha, Angela T Liu, Huy Nguyen, Elizabeth Whisler, Darshini Shah, Shalaka Deshmukh, Navrose Dhaliwal, Ben Bauer, Eskedar Nigatu, Anh Diep, Tom Lopez, Tristan W Fowler, Sung-Jin Lee, Chenggang Lu, Wen-Chen Yeh, Hui Chen, Yang Li

Journal: Cell Chem Biol

PubMed ID: 37413985

Doi: 10.1016/j.chembiol.2023.06.006

Products & Services: Gene Synthesis

Role and neural regulation of clock genes in the rat pineal gland: Clock modulates amplitude of rhythmic expression of Aanat encoding the melatonin-producing enzyme

Authors: Aurea S Blancas-Velazquez, Tenna Bering, Signe Bille, Martin F Rath

Journal: J Pineal Res

PubMed ID: 37349875

Doi: 10.1111/jpi.12893

Products & Services: Proteins, Expression, Isolation and Analysis

Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor

Authors: Wan Ni Chia, Chee Wah Tan, Aaron Wai Kit Tan, Barnaby Young, Tyler N Starr, Ester Lopez, Guntur Fibriansah, Jennifer Barr, Samuel Cheng, Aileen Ying-Yan Yeoh, Wee Chee Yap, Beng Lee Lim, Thiam-Seng Ng, Wan Rong Sia, Feng Zhu, Shiwei Chen, Jinyan Zhang, Madeline Sheng Si Kwek, Allison J Greaney, Mark Chen, Gough G Au, Prasad N Paradkar, Malik Peiris, Amy W Chung, Jesse D Bloom, David Lye, Sheemei Lok, Lin-Fa Wang

Journal: Sci Adv

PubMed ID: 37494438

Doi: 10.1126/sciadv.ade3470

Products & Services: Proteins, Expression, Isolation and Analysis

Breakthrough SARS-CoV-2 Omicron Variant in Individuals Primed with Heterologous Vaccines Enhances Inhibition Performance of Neutralizing Antibody to BA2 Parental Lineage

Authors: Jidapa Szekely, Piyawut Swangphon, Natthaphon Nanakorn, Panuttha Chaimuti, Teerapat Nualnoi, Paweena Wongwitwichot, Namchoke Somapa, Denpong Somapa, Theerakamol Pengsakul

Journal: Vaccines (Basel)

PubMed ID: 37515045

Doi: 10.3390/vaccines11071230

Products & Services: Molecular Biology Reagents

Development of quantitative multiplex RT-qPCR one step assay for detection of hepatitis delta virus

Authors: Jackson Alves da Silva Queiroz, Tárcio Peixoto Roca, Rutilene Barbosa Souza, Luiz Fellype Alves de Souza, Ana Maísa Passos-Silva, André Luiz Ferreira da Silva, Eugênia de Castro E Silva, Lourdes Maria Pinheiro Borzacov, Rita de Cássia Pontello Rampazzo, Soraya Dos Santos Pereira, Thor Oliveira Dantas, Janaína Mazaro, Lívia Melo Villar, Juan Miguel Villalobos Salcedo, Daniel Archimedes da Matta, Deusilene Vieira

Journal: Sci Rep

PubMed ID: 37495613

Doi: 10.1038/s41598-023-37756-z

Products & Services: Molecular Biology Reagents

Absolute Quantification of Photoreceptor Outer Segment Proteins

Authors: Nikolai P Skiba, Tylor R Lewis, William J Spencer, Carson M Castillo, Andrej Shevchenko, Vadim Y Arshavsky

Journal: J Proteome Res

PubMed ID: 37493966

Doi: 10.1021/acs.jproteome.3c00267

Products & Services: Peptide Synthesis

Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity

Authors: Benedikt Goretzki, Christoph Wiedemann, Brett A McCray, Stefan L Schäfer, Jasmin Jansen, Frederike Tebbe, Sarah-Ana Mitrovic, Julia Nöth, Ainara Claveras Cabezudo, Jack K Donohue, Cy M Jeffries, Wieland Steinchen, Florian Stengel, Charlotte J Sumner, Gerhard Hummer, Ute A Hellmich

Journal: Nat Commun

PubMed ID: 37443299

Doi: 10.1038/s41467-023-39808-4

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Structural basis of CXC chemokine receptor 1 ligand binding and activation

Authors: Naito Ishimoto, Jae-Hyun Park, Kouki Kawakami, Michiko Tajiri, Kenji Mizutani, Satoko Akashi, Jeremy R H Tame, Asuka Inoue, Sam-Yong Park

Journal: Nat Commun

PubMed ID: 37433790

Doi: 10.1038/s41467-023-39799-2

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Spatially-Encoding Hydrogels With DNA to Control Cell Signaling

Authors: Namrata Ramani, C Adrian Figg, Alex J Anderson, Peter H Winegar, EunBi Oh, Sasha B Ebrahimi, Devleena Samanta, Chad A Mirkin

Journal: Adv Mater

PubMed ID: 37221642

Doi: 10.1002/adma.202301086

Products & Services: Recombinant Proteins

Tepsin binds LC3B to promote ATG9A export and delivery at the cell periphery

Authors: Natalie S Wallace, John E Gadbery, Cameron I Cohen, Amy K Kendall, Lauren P Jackson

Journal: biorxiv

PubMed ID: 37502979

Doi: 10.1101/2023.07.18.549521

Products & Services: Proteins, Expression, Isolation and Analysis

Non-canonical function of folate/folate receptor 1 during neural tube formation

Authors: Olga A Balashova, Alexios A Panoutsopoulos, Olesya Visina, Jacob Selhub, Paul S Knoepfler, Laura N Borodinsky

Journal: biorxiv

PubMed ID: 37503108

Doi: 10.1101/2023.07.19.549718

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Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis

Authors: Yi Zhou, Guofei Cui, Hongwei Xu, Joanne Chun, Doris Yang, Zheng Zhang, Lihui Yang, Jingxiao Wang, Meijuan Wan, Diego F Calvisi, Shumei Lin, Xin Chen, Haichuan Wang

Journal: Cell Death Dis

PubMed ID: 37500626

Doi: 10.1038/s41419-023-05958-y

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Targeting the Spike Receptor Binding Domain Class V Cryptic Epitope by an Antibody with Pan-Sarbecovirus Activity

Authors: Jaime L Jensen, Rajeshwer S Sankhala, Vincent Dussupt, Hongjun Bai, Agnes Hajduczki, Kerri G Lal, William C Chang, Elizabeth J Martinez, Caroline E Peterson, Emily S Golub, Phyllis A Rees, Letzibeth Mendez-Rivera, Michelle Zemil, Erin Kavusak, Sandra V Mayer, Lindsay Wieczorek, Shruthi Kannan, Benjamin J Doranz, Edgar Davidson, Eun Sung Yang, Yi Zhang, Man Chen, Misook Choe, Lingshu Wang, Gregory D Gromowski, Richard A Koup, Nelson L Michael, Victoria R Polonis, Morgane Rolland, Kayvon Modjarrad, Shelly J Krebs, M Gordon Joyce

Journal: J Virol

PubMed ID: 37395646

Doi: 10.1128/jvi.01596-22

Products & Services: Gene Synthesis

Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes

Authors: Shaun K Bremner, Rebecca Berends, Alexandra Kaupisch, Jennifer Roccisana, Calum Sutherland, Nia J Bryant, Gwyn W Gould

Journal: PeerJ

PubMed ID: 37520260

Doi: 10.7717/peerj.15630

Products & Services: Proteins, Expression, Isolation and Analysis

A natural gene drive system confers reproductive isolation in rice

Authors: Chaolong Wang, Jian Wang, Jiayu Lu, Yehui Xiong, Zhigang Zhao, Xiaowen Yu, Xiaoming Zheng, Jing Li, Qibing Lin, Yulong Ren, Yang Hu, Xiaodong He, Chao Li, Yonglun Zeng, Rong Miao, Mali Guo, Bosen Zhang, Ying Zhu, Yunhui Zhang, Weijie Tang, Yunlong Wang, Benyuan Hao, Qiming Wang, Siqi Cheng, Xiaojuan He, Bowen Yao, Junwen Gao, Xufei Zhu, Hao Yu, Yong Wang, Yan Sun, Chunlei Zhou, Hui Dong, Xiaoding Ma, Xiuping Guo, Xi Liu, Yunlu Tian, Shijia Liu, Chunming Wang, Zhijun Cheng, Ling Jiang, Jiawu Zhou, Huishan Guo, Liwen Jiang, Dayun Tao, Jijie Chai, Wei Zhang, Haiyang Wang, Chuanyin Wu, Jianmin Wan

Journal: Cell

PubMed ID: 37499659

Doi: 10.1016/j.cell.2023.06.023

Products & Services: Proteins, Expression, Isolation and Analysis

Histone deacetylase III interactions with BK polyomavirus large tumor antigen may affect protein stability

Authors: Yueh-Han Hsu, Chun-Nun Chao, Hsin-Yi Huang, Pei-Wen Zhao, Pang-Hung Hsu, Cheng-Huang Shen, San-Yuan Chen, Chiung-Yao Fang

Journal: Virol J

PubMed ID: 37464367

Doi: 10.1186/s12985-023-02128-6

Products & Services: Molecular Biology Reagents

TP5: A Novel Therapeutic Approach Targeting Aberrant and Hyperactive CDK5/p25 for the Treatment of Colorectal Carcinoma

Authors: Niranjana Amin, Herui Wang, Qi Song, Manju Bhaskar, Sharda Prasad Yadav, Mark R Gilbert, Harish Pant, Emeline Tabouret, Zhengping Zhuang

Journal: Int J Mol Sci

PubMed ID: 37511490

Doi: 10.3390/ijms241411733

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Class I histone deacetylase complex: Structure and functional correlates

Authors: Xiao Wang, Yannan Wang, Simiao Liu, Yi Zhang, Ke Xu, Liting Ji, Roger D Kornberg, Heqiao Zhang

Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PubMed ID: 37459529

Doi: 10.1073/pnas.2307598120

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Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS–STING pathway

Authors: Jing An , Chuan-Ping Zhang , Hou-Yuan Qiu , Hong-Xia Zhang , Qiu-Bing Chen , Yu-Ming Zhang , Xin-Lin Lei , Cai-Xiang Zhang , Hao Yin , Ying Zhang

Journal: Nat Biomed Eng .

PubMed ID: 37500747

Doi: 10.1038/s41551-023-01073-7

Products & Services: CRISPR Plasmids

The combination of osimertinib with Raf inhibitor overcomes osimertinib resistance induced by KRAS amplification in EGFR-mutated lung cancer cells

Authors: Tae-Gul Lee, Hye-Min Kang, Seo Yun Kim, Hye-Ryoun Kim, Cheol Hyeon Kim

Journal: Exp Cell Res

PubMed ID: 37442265

Doi: 10.1016/j.yexcr.2023.113722

Products & Services: Proteins, Expression, Isolation and Analysis

Combined Inhibition of the TGF-β1/Smad Pathway by and to Reduce Inflammation and Fibrosis in Primary Sclerosing Cholangitis

Authors: Yu Shen, Baorong Jiang, Chenchen Zhang, Qian Wu, Lei Li, Ping Jiang

Journal: Int J Mol Sci

PubMed ID: 37446187

Doi: 10.3390/ijms241311010

Products & Services: Proteins, Expression, Isolation and Analysis

Viral manipulation of cell polarity signalling

Authors: Airah Javorsky, Patrick O Humbert, Marc Kvansakul

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 37437846

Doi: 10.1016/j.bbamcr.2023.119536

Products & Services: Molecular Biology Reagents

Macrophage infectivity potentiator protein, a peptidyl prolyl cis-trans isomerase, essential for Coxiella burnetii growth and pathogenesis

Authors: Aleksandra W Debowski, Nicole M Bzdyl, David R Thomas, Nichollas E Scott, Christopher H Jenkins, Jua Iwasaki, Emily A Kibble, Chen Ai Khoo, Nicolas J Scheuplein, Pamela M Seibel, Theresa Lohr, Georgie Metters, Charles S Bond, Isobel H Norville, Keith A Stubbs, Nicholas J Harmer, Ulrike Holzgrabe, Hayley J Newton, Mitali Sarkar-Tyson

Journal: PLoS Pathog

PubMed ID: 37399210

Doi: 10.1371/journal.ppat.1011491

Products & Services: Proteins, Expression, Isolation and Analysis

Investigating the aggregation perspective of Dengue virus proteome

Authors: Shivani Krishna Kapuganti, Kumar Udit Saumya, Deepanshu Verma, Rajanish Giri

Journal: Virology

PubMed ID: 37473502

Doi: 10.1016/j.virol.2023.07.010

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Notch Intracellular Domains form Transcriptionally Active Heterodimeric Complexes on Sequence-paired Sites

Authors: Tana R Gazdik, Jacob J Crow, Tyler Lawton, Chloe J Munroe, Hannah Theriault, Travis M Wood, Allan R Albig

Journal: Res Sq

PubMed ID: 37546896

Doi: 10.21203/rs.3.rs-3147210/v1

Products & Services: Proteins, Expression, Isolation and Analysis

Pathogenic CANVAS (AAGGG) repeats stall DNA replication due to the formation of alternative DNA structures

Authors: Julia A Hisey, Elina A Radchenko, Silvia Ceschi, Anastasia Rastokina, Nicholas H Mandel, Ryan J McGinty, Gabriel Matos-Rodrigues, Alfredo Hernandez, André Nussenzweig, Sergei M Mirkin

Journal: biorxiv

PubMed ID: 37546920

Doi: 10.1101/2023.07.25.550509

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Prokaryotic Gabija complex senses and executes nucleotide depletion and DNA cleavage for antiviral defense

Authors: Rui Cheng , Fengtao Huang , Xueling Lu , Yan Yan , Bingbing Yu , Xionglue Wang , Bin Zhu

Journal: Cell Host Microbe .

PubMed ID: 37480847

Doi: 10.1016/j.chom.2023.06.014

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Targeting CXCR4-expressing Cancer Cells with Avidin-poly (lactic-co-glycolic acid) Nanoparticle Surface Modified with Biotinylated DV1 Peptide

Authors: Shiba Ansari, Madeeha Mudassir, B Vijayalekshmi, Parthaprasad Chattopadhyay

Journal: Int J Appl Basic Med Res

PubMed ID: 37614837

Doi: 10.4103/ijabmr.ijabmr_58_23

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Mesothelin-targeting T cell receptor fusion construct cell therapy in refractory solid tumors: phase 1/2 trial interim results

Authors: Raffit Hassan, Marcus Butler, Roisin E O'Cearbhaill, David Y Oh, Melissa Johnson, Kevin Zikaras, Munisha Smalley, Michael Ross, Janos L Tanyi, Azam Ghafoor, Nirali N Shah, Babak Saboury, Liang Cao, Alfonso Quintás-Cardama, David Hong

Journal: Nat Med

PubMed ID: 37501016

Doi: 10.1038/s41591-023-02452-y

Products & Services: Proteins, Expression, Isolation and Analysis

Monitoring SARS-CoV-2 variants in wastewater of Dhaka City, Bangladesh: approach to complement public health surveillance systems

Authors: Rehnuma Haque, Mohammad Enayet Hossain, Mojnu Miah, Mahbubur Rahman, Nuhu Amin, Ziaur Rahman, Md Shariful Islam, Mohammed Ziaur Rahman

Journal: Hum Genomics

PubMed ID: 37420264

Doi: 10.1186/s40246-023-00505-4

Products & Services: Molecular Biology Reagents

Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins

Authors: Ashley P Viera Ortiz, Gregory Cajka, Olamide A Olatunji, Bailey Mikytuck, Ophir Shalem, Edward B Lee

Journal: Brain

PubMed ID: 36516294

Doi: 10.1093/brain/awac479

Products & Services: DNA Sequencing

Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma

Authors: Shiqun Wang , Wei Yan, Lingkai Kong , Shuguang Zuo , Jingyi Wu, Chunxiao Zhu , Huaping Huang , Bohao He, Jie Dong, Jiwu Wei

Journal: Nat Commun .

PubMed ID: 37474548

Doi: 10.1038/s41467-023-39683-z

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Enhanced Carotenoid Production in Chlamydomonas reinhardtii via Overexpression of Endogenous and Exogenous Beta-Carotene Ketolase (BKT) Genes

Authors: Yuanhao Chen , Hong Du , Honghao Liang , Ting Hong , Tangcheng Li

Journal: Int J Mol Sci .

PubMed ID: 37511141

Doi: 1422-0067/24/14/11382

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Perdeuterated GbpA Enables Neutron Scattering Experiments of a Lytic Polysaccharide Monooxygenase

Authors: H V Sørensen, Mateu Montserrat-Canals, Jennifer S M Loose, S Zoë Fisher, Martine Moulin, Matthew P Blakeley, Gabriele Cordara, Kaare Bjerregaard-Andersen, Ute Krengel

Journal: ACS Omega

PubMed ID: 37599915

Doi: 10.1021/acsomega.3c02168

Products & Services: Proteins, Expression, Isolation and Analysis

Immunogenicity and safety of inactivated SARS-CoV-2 vaccine in haemodialysis patients: a prospective cohort study

Authors: Metalia Puspitasari, Prenali D Sattwika, Dzerlina S Rahari, Wynne Wijaya, Auliana R P Hidayat, Nyoman Kertia, Bambang Purwanto, Jarir At Thobari

Journal: Sci Rep

PubMed ID: 37463975

Doi: 10.1038/s41598-023-38628-2

Products & Services: Molecular Biology Reagents

Interspersed expression of CUP-SHAPED COTYLEDON2 and REDUCED COMPLEXITY shapes Cardamine hirsuta complex leaf form

Authors: Neha Bhatia, David Wilson-Sánchez, Sören Strauss, Francesco Vuolo, Bjorn Pieper, Ziliang Hu, Léa Rambaud-Lavigne, Miltos Tsiantis

Journal: Curr Biol

PubMed ID: 37453425

Doi: 10.1016/j.cub.2023.06.037

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A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism

Authors: Yingjia Yao, Yunhan Zhang, Zexu Li, Zhisong Chen, Xiaofeng Wang, Zihan Li, Li Yu, Xiaolong Cheng, Wei Li, Wen-Jie Jiang, Hua-Jun Wu, Zezhong Feng, Jinfu Sun, Teng Fei

Journal: Biochem Biophys Res Commun

PubMed ID: 37467664

Doi: 10.1016/j.bbrc.2023.07.018

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Purification and characterization of human glycerol 3-phosphate dehydrogenases (mitochondrial and cytosolic) by NAD/NADH redox method

Authors: Superior Syngkli, Bidyadhar Das

Journal: Biochimie

PubMed ID: 37481063

Doi: 10.1016/j.biochi.2023.07.015

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N6-Methyladenosine Promotes Translation of VEGFA to Accelerate Angiogenesis in Lung Cancer

Authors: Haisheng Zhang, Jiawang Zhou, Jiexin Li, Zhaotong Wang, Zhuojia Chen, Ziyan Lv, Lichen Ge, Guoyou Xie, Guoming Deng, Yalan Rui, Hongbing Huang, Likun Chen, Hongsheng Wang

Journal: Cancer Res

PubMed ID: 37103476

Doi: 10.1158/0008-5472.CAN-22-2449

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Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1

Authors: Eva-Maria Thüring, Christian Hartmann, Janesha C Maddumage, Airah Javorsky, Birgitta E Michels, Volker Gerke, Lawrence Banks, Patrick O Humbert, Marc Kvansakul, Klaus Ebnet

Journal: Commun Biol

PubMed ID: 37430142

Doi: 10.1038/s42003-023-05088-3

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Activation of PDGF Signaling in the Adult Muscle Stem Cell Niche in Patients With Type 2 Diabetes Mellitus

Authors: Alexandra Fahrner, Nikoleta Alchus Laiferová, Barbara Ukropcová, Jozef Ukropec, Jan Krützfeldt

Journal: J Clin Endocrinol Metab

PubMed ID: 36702759

Doi: 10.1210/clinem/dgad041

Products & Services: Proteins, Expression, Isolation and Analysis

Construction and characterization of a novel miniaturized filamentous phagemid for targeted mammalian gene transfer

Authors: Shirley Wong, Salma Jimenez, Roderick A Slavcev

Journal: Microb Cell Fact

PubMed ID: 37430278

Doi: 10.1186/s12934-023-02135-w

Products & Services: Proteins, Expression, Isolation and Analysis

RNA m5C methylation orchestrates BLCA progression via macrophage reprogramming

Authors: Dali Yan, Yongsong Xie, Liyuan Huang, Yi Zhang, Runhuan Gu, Huaibing Xie, Xing Huang, Hao Luo

Journal: J Cell Mol Med

PubMed ID: 37408139

Doi: 10.1111/jcmm.17826

Products & Services: Proteins, Expression, Isolation and Analysis

Integrated immunoinformatics and subtractive proteomics approach for multi-epitope vaccine designing to combat TIGR4

Authors: Sami S Ashgar, Hani Faidah, Farkad Bantun, Naif A Jalal, Naeem F Qusty, Abdulla Darwish, Shafiul Haque, Essam M Janahi

Journal: Front Mol Biosci

PubMed ID: 37560463

Doi: 10.3389/fmolb.2023.1212119

Products & Services: Proteins, Expression, Isolation and Analysis

Long Non-coding RNA LINC00342 Promotes the Proliferation, Invasion, and Migration of Primary Hepatocellular Carcinoma Cells by Regulating the Expression of miRNA-19a-3p, miRNA-545-5p, and miRNA-203a-3p

Authors: Zong-Xi Yao, Jun-Hao Tu, Yu-Lin Liu, Xiao-Feng Xue, Lei Qin

Journal: Biochem Genet

PubMed ID: 37395850

Doi: 10.1007/s10528-023-10420-x

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A bistable autoregulatory module in the developing embryo commits cells to binary expression fates

Authors: Jiaxi Zhao, Mindy Liu Perkins, Matthew Norstad, Hernan G Garcia

Journal: Curr Biol

PubMed ID: 37453424

Doi: 10.1016/j.cub.2023.06.060

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Generation of Bioactive Peptides from sp and Assessment of Their Potential for Use in the Prevention of Hypertension, Inflammation and Pain

Authors: Maria Hayes, Rotimi E Aluko, Elena Aurino, Leticia Mora

Journal: Mar Drugs

PubMed ID: 37623703

Doi: 10.3390/md21080422

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An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles

Authors: Huanhuan Li, Yixi Wu, Minke Li, Lu Guo, Yaqi Gao, Quan Wang, Jihua Zhang, Zhaohua Lai, Xing Zhang, Lixin Zhu, Ping Lan, Zihe Rao, Yingfang Liu, Huanhuan Liang

Journal: Nat Struct Mol Biol

PubMed ID: 37488357

Doi: 10.1038/s41594-023-01043-2

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TLR5S negatively regulates the TLR5M-mediated NF-κB signaling pathway in Epinephelus coioides

Authors: Liangge He, Xue Yu, Yulin Zhao, Haoran Lin, Yong Zhang, Danqi Lu

Journal: Int J Biol Macromol

PubMed ID: 37517756

Doi: 10.1016/j.ijbiomac.2023.126048

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Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays

Authors: Rui Qing, Mantian Xue, Jiayuan Zhao, Lidong Wu, Andreas Breitwieser, Eva Smorodina, Thomas Schubert, Giovanni Azzellino, David Jin, Jing Kong, Tomás Palacios, Uwe B Sleytr, Shuguang Zhang

Journal: Sci Adv

PubMed ID: 37478177

Doi: 10.1126/sciadv.adf1402

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Tumor Site-Specific Cleavage Improves the Antitumor Efficacy of Antibody-Drug Conjugates

Authors: Keyuan Xu, Jiani Han, Liu Yang, Li Cao, Shuang Li, Zhangyong Hong

Journal: Int J Mol Sci

PubMed ID: 37446189

Doi: 10.3390/ijms241311011

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Peptide/Nanoparticle Biointerfaces for Multistep Tandem Catalysis

Authors: Yuliana Perdomo, Joseph M Slocik, David M Phillips, Marc R Knecht

Journal: J Am Chem Soc

PubMed ID: 37478168

Doi: 10.1021/jacs.3c04097

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Author Correction: A pan-influenza antibody inhibiting neuraminidase via receptor mimicry

Authors: Corey Momont, Ha V Dang, Fabrizia Zatta, Kevin Hauser, Caihong Wang, Julia di Iulio, Andrea Minola, Nadine Czudnochowski, Anna De Marco, Kaitlin Branch, David Donermeyer, Siddhant Vyas, Alex Chen, Elena Ferri, Barbara Guarino, Abigail E Powell, Roberto Spreafico, Samantha S Yim, Dale R Balce, Istvan Bartha, Marcel Meury, Tristan I Croll, David M Belnap, Michael A Schmid, William Timothy Schaiff, Jessica L Miller, Elisabetta Cameroni, Amalio Telenti, Herbert W Virgin, Laura E Rosen, Lisa A Purcell, Antonio Lanzavecchia, Gyorgy Snell, Davide Corti, Matteo Samuele Pizzuto

Journal: Nature

PubMed ID: 37407829

Doi: 10.1038/s41586-023-06385-x

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A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury

Authors: Chen Yang, Huidie Xu, Dong Yang, Yunhao Xie, Mingrui Xiong, Yu Fan, XiKai Liu, Yu Zhang, Yushuo Xiao, Yuchen Chen, Yihao Zhou, Liangliang Song, Chen Wang, Anlin Peng, Robert B Petersen, Hong Chen, Kun Huang, Ling Zheng

Journal: Nat Commun

PubMed ID: 37460623

Doi: 10.1038/s41467-023-40036-z

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Systemic delivery of specific and efficient CRISPR/Cas9 system targeting HPV16 oncogenes using LL-37 antimicrobial peptide in C57BL/6 mice

Authors: Niloofar Khairkhah, Azam Bolhassani, Farzad Rajaei, Reza Najafipour

Journal: J Med Virol

PubMed ID: 37403986

Doi: 10.1002/jmv.28934

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The combined action of the intracellular regions regulates FGFR2 kinase activity

Authors: Chi-Chuan Lin , Lukasz Wieteska , Guillaume Poncet-Montange , Kin Man Suen , Stefan T Arold , Zamal Ahmed , John E Ladbury

Journal: Commun Biol .

PubMed ID: 37452126

Doi: 10.1038/s42003-023-05112-6

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Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins

Authors: Haolan Wang , Ming Guo , Hudie Wei , Yongheng Chen

Journal: Comput Struct Biotechnol J .

PubMed ID: 37560128

Doi: 10.1016/j.csbj.2023.07.017

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Development of miniature base editors using engineered IscB nickase

Authors: Dingyi Han , Qingquan Xiao , Yifan Wang , Hainan Zhang , Xue Dong , Guoling Li , Xiangfeng Kong , Shihao Wang , Jinhui Song , Weihong Zhang , Jingxing Zhou , Lanting Bi , Yuan Yuan , Linyu Shi , Na Zhong , Hui Yang , Yingsi Zhou

Journal: Nat Methods .

PubMed ID: 37231266

Doi: 10.1038/s41592-023-01898-9

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Manganese-based microcrystals equipped with Ythdf1-targeted biomimeticnanovaccines for reinforced dendritic cell spatiotemporal orchestration

Authors: Feng Liu , Lulu Tan, Zheng Dai , Yang Wang , Lei Huang , Yang Zhang , Qian Cheng , Xin Li , Miao-Deng Liu, Lin Wang, Zheng Wang

Journal: Nano Today

Doi: 10.1016/j.nantod.2023.102112

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Biomimetic Nanofibrillar Hydrogel with Cell-Adaptable Network for Enhancing Cellular Mechanotransduction, Metabolic Energetics, and Bone Regeneration

Authors: Xian Xie ， Zhuo Li , Xuefeng Yang , Boguang Yang , Zhixian Zong , Xuemei Wang , Liting Duan , Sien Lin , Gang Li , Liming Bian

Journal: J Am Chem Soc

PubMed ID: 37428960

Doi: 10.1021/jacs.3c02210

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Hypoxic papillary thyroid carcinoma cells-secreted exosomes deliver miR-221-3p to normoxic tumor cells to elicit a pro-tumoral effect by regulating the ZFAND5

Authors: Fan Yu, Xianzhao Deng, Yong Zhong, Bomin Guo, Xiaoping Zhang, Bo Wu

Journal: Exp Cell Res

PubMed ID: 37488006

Doi: 10.1016/j.yexcr.2023.113716

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Structural Basis for the Ribonuclease Activity of a Thermostable CRISPR-Cas13a from Thermoclostridium caenicola

Authors: Feng Wang, Chendi Zhang, Haijiang Xu, Wanting Zeng, Lixin Ma, Zhuang Li

Journal: J Mol Biol

PubMed ID: 37442412

Doi: 10.1016/j.jmb.2023.168197

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Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants

Authors: Ebene R Haycroft, Samantha K Davis, Pradhipa Ramanathan, Ester Lopez, Ruth A Purcell, Li Lynn Tan, Phillip Pymm, Bruce D Wines, P Mark Hogarth, Adam K Wheatley, Jennifer A Juno, Samuel J Redmond, Nicholas A Gherardin, Dale I Godfrey, Wai-Hong Tham, Kevin John Selva, Stephen J Kent, Amy W Chung

Journal: Med Microbiol Immunol

PubMed ID: 37477828

Doi: 10.1007/s00430-023-00773-w

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Effectors of the Type VI Secretion System Have the Potential to Be Modified into Antimicrobial Peptides

Authors: Wenjia Lu, Hao Lu, Chenchen Wang, Gaoyan Wang, Wenqi Dong, Chen Tan

Journal: Microbiol Spectr

PubMed ID: 37470717

Doi: 10.1128/spectrum.00308-23

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Fusion of Substrate-Binding Domains Enhances the Catalytic Capacity of Keratinases and Promotes Enzymatic Conversion of Feather Waste

Authors: Xiaomei Ji, Zheng Peng, Jie Song, Guoqiang Zhang, Juan Zhang

Journal: J Agric Food Chem

PubMed ID: 37462367

Doi: 10.1021/acs.jafc.3c03064

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Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G

Authors: Takahide Kouno, Satoshi Shibata, Megumi Shigematsu, Jaekyung Hyun, Tae Gyun Kim, Hiroshi Matsuo, Matthias Wolf

Journal: Nat Commun

PubMed ID: 37419875

Doi: 10.1038/s41467-023-39796-5

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Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity

Authors: Jay C Groppe, Guorong Lu, Mary R Tandang-Silvas, Anupama Pathi, Shruti Konda, Jingfeng Wu, Viet Q Le, Andria L Culbert, Eileen M Shore, Kristi A Wharton, Frederick S Kaplan

Journal: Biomolecules

PubMed ID: 37509165

Doi: 10.3390/biom13071129

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An integrated genomic approach identifies follistatin as a target of the p63-epidermal growth factor receptor oncogenic network in head and neck squamous cell carcinoma

Authors: Akinsola Oyelakin, Jennifer Sosa, Kasturi Bala Nayak, Alexandra Glathar, Christian Gluck, Isha Sethi, Maria Tsompana, Norma Nowak, Michael Buck, Rose-Anne Romano, Satrajit Sinha

Journal: NAR Cancer

PubMed ID: 37492374

Doi: 10.1093/narcan/zcad038

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Preclinical characterization of the efficacy and safety of biologic N-001 as a novel pain analgesic for post-operative acute pain treatment

Authors: Derek Allen, Samerender Nagam Hanumantharao, Rylie McDonell, Karen-Amanda Irvine, Peyman Sahbaie, David Clark, Paul Blum

Journal: Sci Rep

PubMed ID: 37479740

Doi: 10.1038/s41598-023-38618-4

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Low cross reactivity between wild type and deamidated AAV can lead to false negative results in immune monitoring T-cell assays

Authors: So Jin Bing, Stephanee Warrington, Ronit Mazor

Journal: Front Immunol

PubMed ID: 37469509

Doi: 10.3389/fimmu.2023.1211529

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Ice Recrystallization Inhibition Activity of Soy Protein Hydrolysates

Authors: Madison Fomich, Vermont P Día, Uvinduni I Premadasa, Benjamin Doughty, Hari B Krishnan, Tong Wang

Journal: J Agric Food Chem

PubMed ID: 37466256

Doi: 10.1021/acs.jafc.2c08701

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Transcriptomic analysis of hepatocytes reveals the association between ubiquitin-specific peptidase 1 and yes-associated protein 1 during liver regeneration

Authors: Yalei Zhao, Fen Zhang, Xiaoli Zhang, Zuhong Li, Qian Li, Tianzhi Ni, Ruojing Wang, Liangru Liu, Yingli He, Yingren Zhao

Journal: Regen Ther

PubMed ID: 37534236

Doi: 10.1016/j.reth.2023.07.004

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Network pharmacology, molecular docking and experimental verification of the mechanism of huangqi-jixuecao herb pair in treatment of peritoneal fibrosis

Authors: Huibo Dai , Yun Shan , Manshu Yu ， Funing Wang , Ziren Zhou , Jinyi Sun , Li Sheng , Liyan Huang , Meixiao Sheng

Journal: J Ethnopharmacol .

PubMed ID: 37437794

Doi: 10.1016/j.jep.2023.116874

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The structure and mechanism of action of a distinct class of dicistrovirus intergenic region IRESs

Authors: Irina S Abaeva , Christina Young , Reid Warsaba , Nadiyah Khan , Lan Vy Tran , Eric Jan , Tatyana V Pestova , Christopher U T Hellen

Journal: Nucleic Acids Res .

PubMed ID: 37427788

Doi: 10.1093/nar/gkad569

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Unravelling the Therapeutic Potential of Antibiotics in Hypoxia in a Breast Cancer MCF-7 Cell Line Model

Authors: Almaz A Akhunzianov , Alfiya I Nesterova , Sjoerd Wanrooij , Yulia V Filina , Albert A Rizvanov , Regina R Miftakhova

Journal: Int J Mol Sci .

PubMed ID: 37511298

Doi: 10.3390/ijms241411540

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A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity

Authors: Mingfeng Zhang , Yuanyue Shan , Charles D Cox , Duanqing Pei

Journal: Nat Commun .

PubMed ID: 37402734

Doi: 10.1038/s41467-023-39688-8

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Probing Substrate Transport Effects on Enzymatic Hydrogen Catalysis: An Alternative Proton Transfer Pathway in Putatively Sensory [FeFe] Hydrogenase

Authors: Princess R Cabotaje, Kaija Walter, Afridi Zamader, Ping Huang, Felix Ho, Henrik Land, Moritz Senger, Gustav Berggren

Journal: ACS Catal

PubMed ID: 37560193

Doi: 10.1021/acscatal.3c02314

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Intratumoral immune triads are required for adoptive T cell therapy-mediated elimination of solid tumors

Authors: Gabriel Espinosa-Carrasco, Aurora Scrivo, Paul Zumbo, Asim Dave, Doron Betel, Matthew Hellmann, Bryan M Burt, Hyun-Sung Lee, Andrea Schietinger

Journal: biorxiv

PubMed ID: 37461721

Doi: 10.1101/2023.07.03.547423

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Establishment and characterization of an SV40 immortalized chicken intestinal epithelial cell line

Authors: Federico Ghiselli, Martina Felici, Andrea Piva, Ester Grilli

Journal: Poult Sci

PubMed ID: 37517361

Doi: 10.1016/j.psj.2023.102864

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Siglec15 promotes the migration of thyroid carcinoma cells by enhancing the EGFR protein stability

Authors: Sijing Huang, Zhi Ji, Jinqiang Xu, Yuerong Yang, BingRui Wu, Qihang Chen, Shuting Geng, Yu Si, Jiayue Chen, Yuanyan Wei, Cong Wang, Zhilong Ai, Jianhai Jiang

Journal: Glycobiology

PubMed ID: 37129515

Doi: 10.1093/glycob/cwad037

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Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

Authors: Camille N Pierre, Lily E Adams, Kara Anasti, Derrick Goodman, Sherry Stanfield-Oakley, John M Powers, Dapeng Li, Wes Rountree, Yunfei Wang, Robert J Edwards, S Munir Alam, Guido Ferrari, Georgia D Tomaras, Barton F Haynes, Ralph S Baric, Kevin O Saunders

Journal: biorxiv

PubMed ID: 37546738

Doi: 10.1101/2023.07.25.550460

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The ubiquitin-protein ligase MIEL1 localizes to peroxisomes to promote seedling oleosin degradation and lipid droplet mobilization

Authors: Melissa S Traver , Bonnie Bartel

Journal: Proc Natl Acad Sci U S A .

PubMed ID: 37410814

Doi: 10.1073/pnas.2304870120

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Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer

Authors: Apostolia M Tsimberidou, Kerstin Guenther, Borje S Andersson, Regina Mendrzyk, Amir Alpert, Claudia Wagner, Anna Nowak, Katrin Aslan, Arun Satelli, Fabian Richter, Sabrina Kuttruff-Coqui, Oliver Schoor, Jens Fritsche, Zoe Coughlin, Ali S Mohamed, Kerry Sieger, Becky Norris, Rita Ort, Jennifer Beck, Henry Hiep Vo, Franziska Hoffgaard, Manuel Ruh, Linus Backert, Ignacio I Wistuba, David Fuhrmann, Nuhad K Ibrahim, Van Karlyle Morris, Bryan K Kee, Daniel M Halperin, Graciela M Nogueras-Gonzalez, Partow Kebriaei, Elizabeth J Shpall, David Vining, Patrick Hwu, Harpreet Singh, Carsten Reinhardt, Cedrik M Britten, Norbert Hilf, Toni Weinschenk, Dominik Maurer, Steffen Walter

Journal: Cancer Immunol Res

PubMed ID: 37172100

Doi: 10.1158/2326-6066.CIR-22-0444

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Protein oxidation increases SAMHD1 binding ssDNA via its regulatory site

Authors: Theresa L Simermeyer, Stephanie Batalis, LeAnn C Rogers, Owen J Zalesak, Thomas Hollis

Journal: Nucleic Acids Res

PubMed ID: 37246644

Doi: 10.1093/nar/gkad447

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Author Correction: Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses

Authors: Fredrika Hellgren, Alberto Cagigi, Rodrigo Arcoverde Cerveira, Sebastian Ols, Theresa Kern, Ang Lin, Bengt Eriksson, Michael G Dodds, Edith Jasny, Kim Schwendt, Conrad Freuling, Thomas Müller, Martin Corcoran, Gunilla B Karlsson Hedestam, Benjamin Petsch, Karin Loré

Journal: Nat Commun

PubMed ID: 37429868

Doi: 10.1038/s41467-023-39754-1

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Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States

Authors: Aijing Feng, Sarah Bevins, Jeff Chandler, Thomas J DeLiberto, Ria Ghai, Kristina Lantz, Julianna Lenoch, Adam Retchless, Susan Shriner, Cynthia Y Tang, Suxiang Sue Tong, Mia Torchetti, Anna Uehara, Xiu-Feng Wan

Journal: Nat Commun

PubMed ID: 37429851

Doi: 10.1038/s41467-023-39782-x

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Prediction of cooperative homeodomain DNA binding sites from high-throughput-SELEX data

Authors: Brittany Cain, Jordan Webb, Zhenyu Yuan, David Cheung, Hee-Woong Lim, Rhett A Kovall, Matthew T Weirauch, Brian Gebelein

Journal: Nucleic Acids Res

PubMed ID: 37114997

Doi: 10.1093/nar/gkad318

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Functionally diverse front-end desaturases are widespread in the phylum Annelida

Authors: Marc Ramos-Llorens, Francisco Hontoria, Juan C Navarro, David E K Ferrier, Óscar Monroig

Journal: Biochim Biophys Acta Mol Cell Biol Lipids

PubMed ID: 37517549

Doi: 10.1016/j.bbalip.2023.159377

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Caspase-mediated LPS sensing and pyroptosis signaling in

Authors: Shouwen Chen, Shuxin Li, Hao Chen, Yuxin Gong, Dahai Yang, Yuanxing Zhang, Qin Liu

Journal: Sci Adv

PubMed ID: 37478191

Doi: 10.1126/sciadv.adh4054

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Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity

Authors: Hudie Wei , Haolan Wang , Genxin Wang , Lingzhi Qu , Longying Jiang , Shuyan Dai , Xiaojuan Chen , Ye Zhang , Zhuchu Chen , Youjun Li , Ming Guo , Yongheng Chen

Journal: Nat Commun .

PubMed ID: 37463921

Doi: 10.1038/s41467-023-40087-2

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A Novel Bispecific Antibody for EpCAM-Directed Inhibition of the CD73/Adenosine Immune Checkpoint in Ovarian Cancer

Authors: Emily Maria Ploeg, Isabel Britsch, Anne Paulien van Wijngaarden, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Douwe Freerk Samplonius, Wijnand Helfrich

Journal: Cancers (Basel)

PubMed ID: 37509310

Doi: 10.3390/cancers15143651

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Antibody binding of amyloid beta peptide epimers/isomers and ramifications for immunotherapies and drug development

Authors: Elizabeth R Readel, Arzoo Patel, Joshua I Putman, Siqi Du, Daniel W Armstrong

Journal: Sci Rep

PubMed ID: 37524807

Doi: 10.1038/s41598-023-38788-1

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PAQR9 regulates glucose homeostasis in diabetic mice and modulates insulin secretion in β cells in vitro under stress conditions

Authors: Zixuan Li, Yijun Lin, Shixuan Zhuo, Jinzhu Chen, Lingling Chen, Shuying Wang, Yan Chen

Journal: Mol Cell Endocrinol

PubMed ID: 37499998

Doi: 10.1016/j.mce.2023.112032

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A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation

Authors: Karla Wolf, Jan Kosinski, Toby J Gibson, Nicole Wesch, Volker Dötsch, Maurizio Genuardi, Emanuela Lucci Cordisco, Stefan Zeuzem, Angela Brieger, Guido Plotz

Journal: Nucleic Acids Res

PubMed ID: 37224528

Doi: 10.1093/nar/gkad418

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Increase in SARS-CoV-2 Seroprevalence in UK Domestic Felids Despite Weak Immunogenicity of Post-Omicron Variants

Authors: Grace B Tyson, Sarah Jones, Chloe Montreuil-Spencer, Nicola Logan, Sam Scott, Hagar Sasvari, Michael McDonald, Leigh Marshall, Pablo R Murcia, Brian J Willett, William Weir, Margaret J Hosie

Journal: Viruses

PubMed ID: 37632004

Doi: 10.3390/v15081661

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Systematic investigation on the multi-scale mechanisms of bitter peptide self-assembly for flavor modulation

Authors: Rong Zhang, Wei Jia

Journal: Food Chem

PubMed ID: 37541037

Doi: 10.1016/j.foodchem.2023.137063

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Systematic analysis of the impact of phosphorylation and O-GlcNAcylation on protein subcellular localization

Authors: Senhan Xu, Suttipong Suttapitugsakul, Ming Tong, Ronghu Wu

Journal: Cell Rep

PubMed ID: 37453062

Doi: 10.1016/j.celrep.2023.112796

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