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Photoperiod Induces DNA Methylation Changes in the Melatonin Receptor 1A Gene in Ewes

Authors: Xiaoyun He, Wei Wang, Wei Sun, Mingxing Chu

Journal: Animals (Basel)

PubMed ID: 37370427

Doi: 10.3390/ani13121917

Products & Services: Proteins, Expression, Isolation and Analysis

Persistent serum protein signatures define an inflammatory subcategory of long COVID

Authors: Aarthi Talla, Suhas V Vasaikar, Gregory Lee Szeto, Maria P Lemos, Julie L Czartoski, Hugh MacMillan, Zoe Moodie, Kristen W Cohen, Lamar B Fleming, Zachary Thomson, Lauren Okada, Lynne A Becker, Ernest M Coffey, Stephen C De Rosa, Evan W Newell, Peter J Skene, Xiaojun Li, Thomas F Bumol, M Juliana McElrath, Troy R Torgerson

Journal: Nat Commun

PubMed ID: 37296110

Doi: 10.1038/s41467-023-38682-4

Products & Services: Peptide Synthesis

Identification of a damage-associated molecular pattern (DAMP) receptor and its cognate peptide ligand in sweet potato (Ipomoea batatas)

Authors: Hsueh-Han Lu, Anja K Meents, Judith Fliegmann, Ming-Jing Hwang, Ching-Shu Suen, Diana Masch, Georg Felix, Axel Mithöfer, Kai-Wun Yeh

Journal: Plant Cell Environ

PubMed ID: 37267124

Doi: 10.1111/pce.14633

Products & Services: Peptide Synthesis

LC-MS/MS-Based Absolute Quantitation of Hemoglobin Subunits from Dried Blood Spots Reveals Novel Biomarkers for α-Thalassemia Silent Carriers

Authors: Zhe Ren, Guoying Sun, Qianqian Zhang, Shaomin Zou, Jianhong Chen, Weining Zhao, Guixue Hou, Zeyan Zhong, Jialong Li, Yuhua Ye, Xiangmin Xu, Liang Lin

Journal: Anal Chem

PubMed ID: 37285171

Doi: 10.1021/acs.analchem.3c00895

Products & Services: Molecular Biology Reagents

Hepatic transcriptome analysis provides new insights into ghrelin regulation of the liver in Nile tilapia ()

Authors: Huan Zhong, Chenyi Lou, Bingxin Ren, Jiamin Pi, Tao Dai, Weiling Qin, Yi Zhou

Journal: Front Vet Sci

PubMed ID: 37388466

Doi: 10.3389/fvets.2023.1192195

Products & Services: Molecular Biology Reagents

Varicella-zoster virus proteome-wide T-cell screening demonstrates low prevalence of virus-specific CD8 T-cells in latently infected human trigeminal ganglia

Authors: Michiel van Gent, Werner J D Ouwendijk, Victoria L Campbell, Kerry J Laing, Georges M G M Verjans, David M Koelle

Journal: J Neuroinflammation

PubMed ID: 37308917

Doi: 10.1186/s12974-023-02820-y

Products & Services: Peptide Synthesis

Improved extracellular vesicle-based mRNA delivery for familial hypercholesterolemia treatment

Authors: Zheng Yang, Panpan Ji, Zhelong Li, Rongxin Zhang, Mengying Wei, Yang Yang, Lijun Yuan, Yan Han, Guodong Yang

Journal: Theranostics

PubMed ID: 37351166

Doi: 10.7150/thno.82873

Products & Services: Recombinant Antibody Expression

Engineering Scheffersomyces segobiensis for palmitoleic acid-rich lipid production

Authors: Xiujuan Qian, Huirui Lei, Xinhai Zhou, Lili Zhang, Wenxing Cui, Jie Zhou, Fengxue Xin, Weiliang Dong, Min Jiang, Katrin Ochsenreither

Journal: Microb Biotechnol

PubMed ID: 37351580

Doi: 10.1111/1751-7915.14301

Products & Services: Codon Optimization

Three to four mRNA COVID-19 vaccines in multiple sclerosis patients on immunosuppressive drugs: Seroconversion and variant neutralization

Authors: Céline Louapre, Lisa Belin, Stéphane Marot, Amandine Hippolyte, Edouard Januel, Michella Ibrahim, Lina Jeantin, Karen Zafilaza, Isabelle Malet, Fanny Charbonnier-Beaupel, Michelle Rosenzwajg, Cathia Soulié, Anne-Geneviève Marcelin, Valérie Pourcher

Journal: Eur J Neurol

PubMed ID: 37310391

Doi: 10.1111/ene.15925

Products & Services: Proteins, Expression, Isolation and Analysis

Direct fluorescent labeling of NF186 and NaV16 in living primary neurons using bioorthogonal click chemistry

Authors: Nevena Stajković, Yuanyuan Liu, Aleksandra Arsić, Ning Meng, Hang Lyu, Nan Zhang, Dirk Grimm, Holger Lerche, Ivana Nikić-Spiegel

Journal: J Cell Sci

PubMed ID: 37288813

Doi: 10.1242/jcs.260600

Products & Services: Proteins, Expression, Isolation and Analysis

Efficient enzymatic synthesis of chiral 2,3-dihydro-1,4-benzodioxane motif using engineered lipase B

Authors: Zhiyun Wu, Weifeng Shi, Ming Jin, Wei Zhou

Journal: RSC Adv

PubMed ID: 37350861

Doi: 10.1039/d3ra02623j

Products & Services: Molecular Biology Reagents

Assessment of Broadly Reactive Responses in Patients With MERS-CoV Infection and SARS-CoV-2 Vaccination

Authors: Hadeel T Zedan, Maria K Smatti, Swapna Thomas, Gheyath K Nasrallah, Nahla M Afifi, Ali Ait Hssain, Laith J Abu Raddad, Peter V Coyle, Jean-Charles Grivel, Muna A Almaslamani, Asmaa A Althani, Hadi M Yassine

Journal: JAMA Netw Open

PubMed ID: 37389876

Doi: 10.1001/jamanetworkopen.2023.19222

Products & Services: Proteins, Expression, Isolation and Analysis

Trypanosoma cruzi Tc24 Antigen Expressed and Orally Delivered by Schizochytrium sp Microalga is Immunogenic in Mice

Authors: Abel Ramos-Vega, Elizabeth Monreal-Escalante, Sergio Rosales-Mendoza, Bernardo Bañuelos-Hernández, Eric Dumonteil, Carlos Angulo

Journal: Mol Biotechnol

PubMed ID: 37344711

Doi: 10.1007/s12033-023-00763-6

Products & Services: Peptide Synthesis

Atomic model for core modifying region of human fatty acid synthase in complex with Denifanstat

Authors: S M Naimul Hasan, Jennifer W Lou, Alexander F A Keszei, David L Dai, Mohammad T Mazhab-Jafari

Journal: Nat Commun

PubMed ID: 37308485

Doi: 10.1038/s41467-023-39266-y

Products & Services: Plasmid DNA Preparation

PGC7 regulates H3K27me3 modification by inhibiting the interaction of YY1 with PRC2

Authors: Weijie Hao, Chenyang Huang, Defu Liu, Hongyu Xu, Yingxiang Liu, Yian Guan, Bingxue Chen, Zekun Guo

Journal: Am J Physiol Cell Physiol

PubMed ID: 37306391

Doi: 10.1152/ajpcell.00041.2023

Three neutralizing mAbs induced by MPXV A29L protein recognizing different epitopes act synergistically against orthopoxvirus

Authors: Mengjun Li, Zuning Ren, Yuelin Wang, Yushan Jiang, Minghui Yang, Delin Li, Jiayin Chen, Zuxin Liang, Yuhao Lin, Zhujun Zeng, Rui Xu, Yiting Wang, Li Zhu, Weiwei Xiao, Qinghua Wu, Bao Zhang, Chengsong Wan, Yang Yang, Bo Wu, Jie Peng, Wei Zhao, Chenguang Shen

Journal: Emerging Microbes & Infections.

PubMed ID: 37288876

Doi: 10.1080/22221751.2023.2223669

Products & Services: Peptide Synthesis

Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis

Authors: Tian Xie , Peng Liu , Xinyue Wu , Feitong Dong, Zike Zhang, Jian Yue, Usha Mahawar, Faheem Farooq, Hisham Vohra, Qi Fang, Wenchen Liu, Binks W Wattenberg, Xin Gong

Journal: Nat Commun.

PubMed ID: 37308477

Doi: 10.1038/s41467-023-39274-y

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of Anti-Influenza A Compounds Inhibiting the Viral Non-Structural Protein 1 (NS1) Using a Type I Interferon-Driven Screening Strategy

Authors: Giulia Marsili, Chiara Acchioni, Anna Lisa Remoli, Donatella Amatore, Rossella Sgarbanti, Marta De Angelis, Roberto Orsatti, Marta Acchioni, Andrea Astolfi, Nunzio Iraci, Simona Puzelli, Marzia Facchini, Edvige Perrotti, Violetta Cecchetti, Stefano Sabatini, Fabiana Superti, Mariangela Agamennone, Maria Letizia Barreca, John Hiscott, Lucia Nencioni, Marco Sgarbanti

Journal: Int J Mol Sci

PubMed ID: 37445672

Doi: 10.3390/ijms241310495

Products & Services: Gene Synthesis

The SnRK23-AREB1-TST1/2 cascade activated by cytosolic glucose regulates sugar accumulation across tonoplasts in apple and tomato

Authors: Lingcheng Zhu, Yanzhen Li, Chengcheng Wang, Zhiqi Wang, Wenjing Cao, Jing Su, Yunjing Peng, Baiyun Li, Baiquan Ma, Fengwang Ma, Yong-Ling Ruan, Mingjun Li

Journal: Nat Plants

PubMed ID: 37291399

Doi: 10.1038/s41477-023-01443-8

Products & Services: Molecular Biology Reagents

Rapid and definitive treatment of phenylketonuria in variant-humanized mice with corrective editing

Authors: Dominique L Brooks, Manuel J Carrasco, Ping Qu, William H Peranteau, Rebecca C Ahrens-Nicklas, Kiran Musunuru, Mohamad-Gabriel Alameh, Xiao Wang

Journal: Nat Commun

PubMed ID: 37301931

Doi: 10.1038/s41467-023-39246-2

Products & Services: Molecular Biology Reagents

Novel mechanisms for the removal of strong replication-blocking HMCES- and thiazolidine-DNA adducts in humans

Authors: Yohei Sugimoto, Yuji Masuda, Shigenori Iwai, Yumi Miyake, Rie Kanao, Chikahide Masutani

Journal: Nucleic Acids Res

PubMed ID: 37021581

Doi: 10.1093/nar/gkad246

Products & Services: Peptide Synthesis

Protein O-GlcNAcylation homeostasis regulates facultative heterochromatin to fine-tune sog-Dpp signaling during Drosophila early embryogenesis

Authors: Yaowen Zhang, Haibin Yu, Dandan Wang, Xiaoyun Lei, Yang Meng, Na Zhang, Fang Chen, Lu Lv, Qian Pan, Hongtao Qin, Zhuohua Zhang, Daan M F van Aalten, Kai Yuan

Journal: J Genet Genomics

PubMed ID: 37286164

Doi: 10.1016/j.jgg.2023.05.014

Products & Services: Proteins, Expression, Isolation and Analysis

Lymphocyte transformation test in the diagnosis of adult fish-induced enterocolitis syndrome

Authors: Ana Entrala, Javier Domínguez-Ortega, Elisa Pulido Lucas, Itsaso Losantos, Magdalena Lluch-Bernal, Santiago Quirce, Rosa Rodríguez-Perez

Journal: J Allergy Clin Immunol Pract

PubMed ID: 37329953

Doi: 10.1016/j.jaip.2023.06.013

Products & Services: Molecular Biology Reagents

Effect of moderate prenatal ethanol exposure on the differential expression of two histamine H3 receptor isoforms in different brain regions of adult rat offspring

Authors: Suzy Davies, Kiana S Lujan, Ella J Rappaport, Carlos F Valenzuela, Daniel D Savage

Journal: Front Neurosci

PubMed ID: 37449267

Doi: 10.3389/fnins.2023.1192096

Products & Services: Proteins, Expression, Isolation and Analysis

Multisite transformation in : insights on transformations mechanisms and new genetic modification protocols

Authors: Vui Yin Seow, Olga Tsygelnytska, Nicolas Biais

Journal: Front Microbiol

PubMed ID: 37408636

Doi: 10.3389/fmicb.2023.1178128

Products & Services: Gene Synthesis

MERS-CoV RBD-mRNA vaccine induces potent and broadly neutralizing antibodies with protection against MERS-CoV infection

Authors: Wanbo Tai, Jian Zheng, Xiujuan Zhang, Juan Shi, Gang Wang, Xiaoqing Guan, Jiang Zhu, Stanley Perlman, Lanying Du

Journal: Virus Res

PubMed ID: 37336390

Doi: 10.1016/j.virusres.2023.199156

Products & Services: Molecular Biology Reagents

Two Recombinant Bacteriocins, Rhamnosin and Lysostaphin, Show Synergistic Anticancer Activity Against Gemcitabine-Resistant Cholangiocarcinoma Cell Lines

Authors: Kankamol Kerdkumthong, Wannarat Chanket, Phanthipha Runsaeng, Sutthipong Nanarong, Kawinnath Songsurin, Phonprapavee Tantimetta, Chanan Angsuthanasombat, Aratee Aroonkesorn, Sumalee Obchoei

Journal: Probiotics Antimicrob Proteins

PubMed ID: 37294416

Doi: 10.1007/s12602-023-10096-0

Products & Services: Molecular Biology Reagents

GRT-R910: a self-amplifying mRNA SARS-CoV-2 vaccine boosts immunity for ≥6 months in previously-vaccinated older adults

Authors: Christine D Palmer, Ciaran D Scallan, Lauren D Kraemer Tardif, Melissa A Kachura, Amy R Rappaport, Daniel O Koralek, Alison Uriel, Leonid Gitlin, Joshua Klein, Matthew J Davis, Harshni Venkatraman, Meghan G Hart, Jason R Jaroslavsky, Sonia Kounlavouth, Martina Marrali, Charmaine N Nganje, Kyounghwa Bae, Tiffany Yan, Katharyn Leodones, Milana Egorova, Sue-Jean Hong, Jenchun Kuan, Silvia Grappi, Pedro Garbes, Karin Jooss, Andrew Ustianowski

Journal: Nat Commun

PubMed ID: 37280238

Doi: 10.1038/s41467-023-39053-9

Products & Services: Peptide Synthesis

Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS

Authors: Yuta Adachi, Ryo Kimura, Kentaro Hirade, Shogo Yanase, Yuki Nishioka, Natsumi Kasuga, Rui Yamaguchi, Hiromichi Ebi

Journal: Nat Cancer

PubMed ID: 37277529

Doi: 10.1038/s43018-023-00575-2

Products & Services: PCR Cloning and Subcloning

Structural mechanism of intracellular autoregulation of zinc uptake in ZIP transporters

Authors: Changxu Pang, Jin Chai, Ping Zhu, John Shanklin, Qun Liu

Journal: Nat Commun

PubMed ID: 37296139

Doi: 10.1038/s41467-023-39010-6

Products & Services: Gene Synthesis

Flavonoid quercetin and its glucuronide and sulfate conjugates bind to 67-kDa laminin receptor and prevent neuronal cell death induced by serum starvation

Authors: Rayudu Gopalakrishna, Andrew Oh, Lucas Hou, Emily Lee, Jennifer Aguilar, Andrew Li, William J Mack

Journal: Biochem Biophys Res Commun

PubMed ID: 37300941

Doi: 10.1016/j.bbrc.2023.06.007

Products & Services: Peptide Synthesis

Neutralizing Antibodies in COVID-19 Serum from Tatarstan, Russia

Authors: Shaimaa Hamza, Ekaterina Martynova, Ekaterina Garanina, Venera Shakirova, Alisa Bilalova, Svetlana Moiseeva, Ilsiyar Khaertynova, Olesia Ohlopkova, Nataliya Blatt, Maria Markelova, Svetlana Khaiboullina

Journal: Int J Mol Sci

PubMed ID: 37373331

Doi: 10.3390/ijms241210181

Products & Services: Proteins, Expression, Isolation and Analysis

Wheat Class III Peroxidase TaPOD70 Is a Potential Susceptibility Factor Negatively Regulating Wheat Resistance to f sp

Authors: Ruobing Li, Xiaoxu Zhang, Bingjie Zhao, Panpan Song, Xiaomei Zhang, Baotong Wang, Qiang Li

Journal: Phytopathology

PubMed ID: 36812407

Doi: 10.1094/PHYTO-01-23-0001-FI

Products & Services: Proteins, Expression, Isolation and Analysis

Void Volume Fraction of Granular Scaffolds

Authors: Lindsay Riley, Grace Wei, Yijun Bao, Peter Cheng, Katrina L Wilson, Yining Liu, Yiyang Gong, Tatiana Segura

Journal: Small

PubMed ID: 37267936

Doi: 10.1002/smll.202303466

Products & Services: Peptide Synthesis

A novel self-purified auxiliary protein enhances the lichenase activity towards lichenan for biomass degradation

Authors: Rui Zhou, Lingzhi Zhang, Bo Zeng, Yanhong Zhou, Wenhui Jin, Guangya Zhang

Journal: Appl Microbiol Biotechnol

PubMed ID: 37272940

Doi: 10.1007/s00253-023-12608-y

Products & Services: Proteins, Expression, Isolation and Analysis

Rapid and Facile Light-Based Approach to Fabricate Protease-Degradable Poly(ethylene glycol)-norbornene Microgels for Cell Encapsulation

Authors: Ana Mora-Boza, Saron G Ghebrezadik, Johannes E Leisen, Andrés J García

Journal: Adv Healthc Mater

PubMed ID: 37235850

Doi: 10.1002/adhm.202300942

Products & Services: Molecular Biology Reagents

Schlafen4-MDSC in -induced gastric metaplasia reveals role for GTPases

Authors: Lin Ding, Sulaiman Sheriff, Ricky A Sontz, Juanita L Merchant

Journal: Front Immunol

PubMed ID: 37334372

Doi: 10.3389/fimmu.2023.1139391

Products & Services: Peptide Synthesis

Functional Diversity of Homologous Oxidoreductases-Tuning of Substrate Specificity by a FAD-Stacking Residue for Iron Acquisition and Flavodoxin Reduction

Authors: Marta Hammerstad, Anne Kristine Rugtveit, Sondov Dahlen, Hilde Kristin Andersen, Hans-Petter Hersleth

Journal: Antioxidants (Basel)

PubMed ID: 37371954

Doi: 10.3390/antiox12061224

Products & Services: Gene Synthesis

Engineering B cells with customized therapeutic responses using a synthetic circuit

Authors: Audrey Page, Marie Delles, Didier Nègre, Caroline Costa, Floriane Fusil, François-Loïc Cosset

Journal: Mol Ther Nucleic Acids

PubMed ID: 37359346

Doi: 10.1016/j.omtn.2023.05.024

Products & Services: PCR Cloning and Subcloning

Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

Authors: Liang Chen, Mengjia Hong, Changming Luan, Hongyi Gao, Gaomeng Ru, Xinyuan Guo, Dujuan Zhang, Shun Zhang, Changwei Li, Jun Wu, Peyton B Randolph, Alexander A Sousa, Chao Qu, Yifan Zhu, Yuting Guan, Liren Wang, Mingyao Liu, Bo Feng, Gaojie Song, David R Liu, Dali Li

Journal: Nat Biotechnol

PubMed ID: 37322276

Doi: 10.1038/s41587-023-01821-9

Folding Double-Stranded DNA into Designed Shapes with Triplex-Forming Oligonucleotides

Authors: Cindy Ng , Anirban Samanta , Ole Aalund Mandrup , Emily Tsang , Sarah Youssef , Lasse Hyldgaard Klausen , Mingdong Dong , Minke A D Nijenhuis , Kurt V Gothelf

Journal: Adv Mater .

PubMed ID: 37311656

Doi: 10.1002/adma.202302497

Products & Services: DNA Sequencing

A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells

Authors: Aoxing Cheng, Tian Xu , Weiyi You, Ting Wang, Dongming Zhang, Huimin Guo , Haiyan Zhang , Xin Pan , Yucai Wang , Liu Liu , Kaiguang Zhang , Jue Shi , Xuebiao Yao ， Jing Guo , Zhenye Yang

Journal: Nat Metab .

PubMed ID: 37349486

Doi: 10.1038/s42255-023-00832-9

Products & Services: Antibody Modification and Purification Services

Improving therapeutic protein secretion in the probiotic yeast Saccharomyces boulardii using a multifactorial engineering approach

Authors: Deniz Durmusoglu, Ibrahim Al'Abri, Zidan Li, Taufika Islam Williams, Leonard B Collins, José L Martínez, Nathan Crook

Journal: Microb Cell Fact

PubMed ID: 37287064

Doi: 10.1186/s12934-023-02117-y

Products & Services: Proteins, Expression, Isolation and Analysis

Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae

Authors: Mitchell A Ellison, Sanchirmaa Namjilsuren, Margaret K Shirra, Matthew S Blacksmith, Rachel A Schusteff, Eleanor M Kerr, Fei Fang, Yufei Xiang, Yi Shi, Karen M Arndt

Journal: Nucleic Acids Res

PubMed ID: 36928138

Doi: 10.1093/nar/gkad180

Products & Services: Proteins, Expression, Isolation and Analysis

Targeted sequencing of cancer-related genes reveals a recurrent TOP2A variant which affects DNA binding and coincides with global transcriptional changes in glioblastoma

Authors: Bartlomiej Gielniewski, Katarzyna Poleszak, Adria-Jaume Roura, Paulina Szadkowska, Karol Jacek, Sylwia K Krol, Rafal Guzik, Paulina Wiechecka, Marta Maleszewska, Beata Kaza, Andrzej Marchel, Tomasz Czernicki, Andrzej Koziarski, Grzegorz Zielinski, Andrzej Styk, Maciej Kawecki, Cezary Szczylik, Ryszard Czepko, Mariusz Banach, Wojciech Kaspera, Wojciech Szopa, Mateusz Bujko, Bartosz Czapski, Miroslaw Zabek, Ewa Iżycka-Świeszewska, Wojciech Kloc, Pawel Nauman, Joanna Cieslewicz, Wieslawa Grajkowska, Natalia Morosini, Houtan Noushmehr, Bartosz Wojtas, Bozena Kaminska

Journal: Int J Cancer

PubMed ID: 37338006

Doi: 10.1002/ijc.34631

Products & Services: Proteins, Expression, Isolation and Analysis

Virtual screening, identification, and potential antioxidant mechanism of novel bioactive peptides during aging by a short-chain peptidomics, quantitative structure-activity relationship analysis, and molecular docking

Authors: An Du, Wei Jia

Journal: Food Res Int

PubMed ID: 37689894

Doi: 10.1016/j.foodres.2023.113129

Products & Services: Proteins, Expression, Isolation and Analysis

Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection

Authors: Manuela C Aguirre-Botero, Lawrence T Wang, Pauline Formaglio, Eduardo Aliprandini, Jean-Michel Thiberge, Arne Schön, Yevel Flores-Garcia, Shamika Mathis-Torres, Barbara J Flynn, Lais da Silva Pereira, Yann Le Duff, Mathew Hurley, Adéla Nacer, Paul W Bowyer, Fidel Zavala, Azza H Idris, Joseph R Francica, Robert A Seder, Rogerio Amino

Journal: Cell Rep

PubMed ID: 37389992

Doi: 10.1016/j.celrep.2023.112681

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Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases

Authors: Victoria A Kleiner, Thierry O Fischmann, John A Howe, Douglas C Beshore, Michael J Eddins, Yan Hou, Todd Mayhood, Daniel Klein, Debbie D Nahas, Bob J Lucas, He Xi, Edward Murray, Daphne Y Ma, Krista Getty, Rachel Fearns

Journal: Commun Biol

PubMed ID: 37337079

Doi: 10.1038/s42003-023-04990-0

Products & Services: Codon Optimization

Near atmospheric carbon dioxide activates plant ubiquitin cross-linking

Authors: Harry G Gannon, Martin J Cann

Journal: BBA Adv

PubMed ID: 37416898

Doi: 10.1016/j.bbadva.2023.100096

Products & Services: Molecular Biology Reagents

A bioengineered pseudovirus nanoparticle displaying SARS-CoV 2 RBD fully protects mice from mortality and weight loss caused by SARS-CoV 2 challenge

Authors: Ming Xia, Krisangel López, Frank S Vago, Pengwei Huang, Dawn I Auguste, Wen Jiang, Albert J Auguste, Ming Tan

Journal: Biotechnol J

PubMed ID: 37300425

Doi: 10.1002/biot.202300130

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Assessing the Feasibility of Employing a Combination of a Bacteriophage-Derived Endolysin and Spore Germinants to Treat Relapsing Infection

Authors: Khalid Alyahya, Les Baillie

Journal: Microorganisms

PubMed ID: 37512824

Doi: 10.3390/microorganisms11071651

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Expression and characterization of recombinant IL-1Ra in Aspergillus oryzae as a system

Authors: Lena Mahmoudi Azar, Elif Karaman, Burcu Beyaz, Işılay Göktan, Alp Ertunga Eyüpoğlu, Seda Kizilel, Batu Erman, Ahmet Gül, Serdar Uysal

Journal: BMC Biotechnol

PubMed ID: 37340430

Doi: 10.1186/s12896-023-00785-7

Products & Services: Gene Synthesis

Identification of paeoniflorin from Paeonia lactiflora pall As an inhibitor of tryptophan 2,3-dioxygenase and assessment of its pharmacological effects on depressive mice

Authors: Xiaoxia Liang, Ting Su, Pingzhou Wu, Yanting Dai, Yanmin Chen, QiQi Wang, Cheng Cao, Fenglian Chen, Qing Wang, Shuling Wang

Journal: J Ethnopharmacol

PubMed ID: 37315645

Doi: 10.1016/j.jep.2023.116714

Products & Services: Proteins, Expression, Isolation and Analysis

Antibody aggregation can lead to reduced Protein A binding capacity and low step yield

Authors: Gaoya Yuan, Meng Qu, Qi Geng, Wanyuan Dong, Xudong Zhang, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 37271409

Doi: 10.1016/j.pep.2023.106315

Products & Services: Proteins, Expression, Isolation and Analysis

Targeted deprivation of methionine with engineered Salmonella leads to oncolysis and suppression of metastasis in broad types of animal tumor models

Authors: Sujin Zhou, Yan Lin, Zhenggang Zhao, Yunhao Lai, Mengmeng Lu, Zishen Shao, Xinyu Mo, Yunping Mu, Zhipeng Liang, Xinxing Wang, Jingming Qu, Hua Shen, Fanghong Li, Allan Z Zhao

Journal: Cell Rep Med

PubMed ID: 37269826

Doi: 10.1016/j.xcrm.2023.101070

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Preferential rabbit antibody responses to C-termini of NOTCH3 peptide immunogens

Authors: Soo Jung Lee , Mitchell B Gasche , Connor J Burrows , Akhil Kondepudi , Xiaojie Zhang, Michael M Wang

Journal: Sci Rep .

PubMed ID: 37280231

Doi: 10.1038/s41598-023-36067-7

Products & Services: Proteins, Expression, Isolation and Analysis

Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane

Authors: Wei Shi, Yongfei Cai, Haisun Zhu, Hanqin Peng, Jewel Voyer, Sophia Rits-Volloch, Hong Cao, Megan L Mayer, Kangkang Song, Chen Xu, Jianming Lu, Jun Zhang, Bing Chen

Journal: Nature

PubMed ID: 37285872

Doi: 10.1038/s41586-023-06273-4

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery, characterization, and redesign of potent antimicrobial thanatin orthologs from and targeting LptA

Authors: Kelly Huynh, Amanuel Kibrom, Bruce R Donald, Pei Zhou

Journal: J Struct Biol X

PubMed ID: 37416832

Doi: 10.1016/j.yjsbx.2023.100091

Products & Services: Peptide Synthesis

Bac to Bac System Efficiency for Preparing HPV Type 16 Virus-Like Particle Vaccine

Authors: H Razavi-Nikoo, E Behboudi, B Aghcheli, S M A Hashemi, A Moradi

Journal: Arch Razi Inst

PubMed ID: 38028838

Doi: 10.22092/ARI.2023.361975.2708

Products & Services: Proteins, Expression, Isolation and Analysis

Development and qualification of cell-based relative potency assay for a human respiratory syncytial virus (RSV) mRNA vaccine

Authors: Hualin Helen Li, Jenny Xu, Li He, Lynne Ireland Denny, Richard R Rustandi, Geethanjali Dornadula, Brock Fiorito, Zhi-Qiang Zhang

Journal: J Pharm Biomed Anal

PubMed ID: 37336039

Doi: 10.1016/j.jpba.2023.115523

Products & Services: Proteins, Expression, Isolation and Analysis

Protein-protein interactions between tenascin-R and RPTPζ/phosphacan are critical to maintain the architecture of perineuronal nets

Authors: Ashis Sinha, Jessica Kawakami, Kimberly S Cole, Aliona Ladutska, Mary Y Nguyen, Mary S Zalmai, Brandon L Holder, Victor M Broerman, Russell T Matthews, Samuel Bouyain

Journal: J Biol Chem

PubMed ID: 37356715

Doi: 10.1016/j.jbc.2023.104952

Products & Services: Proteins, Expression, Isolation and Analysis

Compound from Magnolia officinalis Ameliorates White Matter Injury by Promoting Oligodendrocyte Maturation in Chronic Cerebral Ischemia Models

Authors: Zhi Zhang, Xin Shu, Qian Cao, Lushan Xu, Zibu Wang, Chenggang Li, Shengnan Xia, Pengfei Shao, Xinyu Bao, Liang Sun, Yuhao Xu, Yun Xu

Journal: Neurosci Bull

PubMed ID: 37291477

Doi: 10.1007/s12264-023-01068-z

Products & Services: Proteins, Expression, Isolation and Analysis

Expression and purification of the mitochondrial transmembrane protein FAM210A in Escherichia coli

Authors: Jared Hollinger, Jiangbin Wu, Kamel M Awayda, Mitchell R O'Connell, Peng Yao

Journal: Protein Expr Purif

PubMed ID: 37329934

Doi: 10.1016/j.pep.2023.106322

Products & Services: Proteins, Expression, Isolation and Analysis

Optimization of genetic code expansion in the baculovirus expression vector system (BEVS)

Authors:

Journal: Protein Expr Purif

PubMed ID: 37269916

Doi: 10.1016/j.pep.2023.106314

Products & Services: Proteins, Expression, Isolation and Analysis

Boophilin D1, a Kunitz type protease inhibitor, as a source of inhibitors for the ZIKA virus NS2B-NS3 protease

Authors: Veronica de Moraes Manzato, Camila Di Santo, Ricardo Jose Soares Torquato, Camila Coelho, Gloria Gallo, Leon Hardy, Martin Würtele, Aparecida Sadae Tanaka

Journal: Biochimie

PubMed ID: 37364769

Doi: 10.1016/j.biochi.2023.06.010

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Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3

Authors: Hayarpi Torosyan, Michael D Paul, Antoine Forget, Megan Lo, Devan Diwanji, Krzysztof Pawłowski, Nevan J Krogan, Natalia Jura, Kliment A Verba

Journal: Nat Commun

PubMed ID: 37336883

Doi: 10.1038/s41467-023-38864-0

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Increasing sensitivity of antibody-antigen interactions using photo-cross-linking

Authors: Alba Torrents de la Peña, Leigh M Sewall, Rebeca de Paiva Froes Rocha, Abigail M Jackson, Payal P Pratap, Sandhya Bangaru, Christopher A Cottrell, Subhasis Mohanty, Albert C Shaw, Andrew B Ward

Journal: Cell Rep Methods

PubMed ID: 37426749

Doi: 10.1016/j.crmeth.2023.100509

Products & Services: Proteins, Expression, Isolation and Analysis

Stability and structure-activity relationship of the SPA4 peptide under ambient and stressed conditions of lung injury

Authors: Asif Alam Chowdhury, Karla Rodgers, Nachiket M Godbole, Shanjana Awasthi

Journal: RSC Adv

PubMed ID: 37350860

Doi: 10.1039/d3ra02918b

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Assimilatory sulfate reduction in the marine methanogen Methanothermococcus thermolithotrophicus

Authors: Marion Jespersen, Tristan Wagner

Journal: Nat Microbiol

PubMed ID: 37277534

Doi: 10.1038/s41564-023-01398-8

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Mycobacterium abscessus VapC5 toxin potentiates evasion of antibiotic killing by ribosome overproduction and activation of multiple resistance pathways

Authors: Eduardo A Troian, Heather M Maldonado, Unnati Chauhan, Valdir C Barth, Nancy A Woychik

Journal: Nat Commun

PubMed ID: 37349306

Doi: 10.1038/s41467-023-38844-4

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Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals

Authors: Ye Zhao, Huiling Wang, Tianhua He, Bo Ma, Guoguang Chen, Chimeng Tzeng

Journal: J Cell Commun Signal

PubMed ID: 37338798

Doi: 10.1007/s12079-023-00775-6

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Identification and Characterization of an HtrA Sheddase Produced by Coxiella burnetii

Authors: Ikram Omar Osman , Aurelia Caputo , Lucile Pinault , Jean-Louis Mege , Anthony Levasseur , Christian A Devaux

Journal: Int J Mol Sci .

PubMed ID: 37446087

Doi: 10.3390/ijms241310904

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Spatiotemporal and global profiling of DNA–protein interactions enables discovery of low-affinity transcription factors

Authors: An-Di Guo , Ke-Nian Yan, Hao Hu , Linhui Zhai , Teng-Fei Hu , Haixia Su , Yijia Chi , Jinyin Zha , Yechun Xu , Dongxin Zhao , Xiaojie Lu , Yong-Jiang Xu , Jian Zhang , Minjia Tan, Xiao-Hua Chen

Journal: Nat Chem .

PubMed ID: 37106095

Doi: 10.1038/s41557-023-01196-z

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Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing

Authors: Hyatt Balke-Want, Vimal Keerthi, Nikolaos Gkitsas, Andrew G Mancini, Gavin L Kurgan, Carley Fowler, Peng Xu, Xikun Liu, Kyle Asano, Sunny Patel, Christopher J Fisher, Annie K Brown, Ramya H Tunuguntla, Shabnum Patel, Elena Sotillo, Crystal L Mackall, Steven A Feldman

Journal: Mol Cancer

PubMed ID: 37365642

Doi: 10.1186/s12943-023-01799-7

Products & Services: Proteins, Expression, Isolation and Analysis

Genome-wide characterization of extrachromosomal circular DNA in gastric cancer and its potential role in carcinogenesis and cancer progression

Authors: Xianming Jiang, Xiaoguang Pan, Wenchao Li, Peng Han, Jiaying Yu, Jing Li, Haoran Zhang, Wei Lv, Ying Zhang, Yulong He, Xi Xiang

Journal: Cell Mol Life Sci

PubMed ID: 37369919

Doi: 10.1007/s00018-023-04838-0

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CLDN182 and 4-1BB bispecific antibody givastomig exerts antitumor activity through CLDN182-expressing tumor-directed T-cell activation

Authors: Jing Gao, Zhengyi Wang, Wenqing Jiang, Yanni Zhang, Zhen Meng, Yanling Niu, Zhen Sheng, Chan Chen, Xuejun Liu, Xi Chen, Chanjuan Liu, Keren Jia, Cheng Zhang, Haiyan Liao, Jaeho Jung, Eunsil Sung, Hyejin Chung, Jingwu Z Zhang, Andrew X Zhu, Lin Shen

Journal: J Immunother Cancer

PubMed ID: 37364935

Doi: 10.1136/jitc-2023-006704

Products & Services: Proteins, Expression, Isolation and Analysis

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway

Authors: Songnan Wang, Volker Böhnert, Alby J Joseph, Valentino Sudaryo, Jason Swinderman, Feiqiao B Yu, Xuchao Lyu, Gemini Skariah, Vishvak Subramanyam, Luke A Gilbert, Hani Goodarzi, Li Lingyin

Journal: biorxiv

PubMed ID: 37333273

Doi: 10.1101/2023.06.01.543353

Products & Services: Proteins, Expression, Isolation and Analysis

Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene

Authors: Lindsey M Vansandt, Marie-Charlotte Meinsohn, Philippe Godin, Nicholas Nagykery, Natalie Sicher, Motohiro Kano, Aki Kashiwagi, Maeva Chauvin, Hatice D Saatcioglu, Julie L Barnes, Amy G Miller, Amy K Thompson, Helen L Bateman, Elizabeth M Donelan, Raquel González, Jackie Newsom, Guangping Gao, Patricia K Donahoe, Dan Wang, William F Swanson, David Pépin

Journal: Nat Commun

PubMed ID: 37280258

Doi: 10.1038/s41467-023-38721-0

Products & Services: Codon Optimization

Novel SPEA Superantigen Peptide Agonists and Peptide Agonist-TGFαL3 Conjugate In Vitro Study of Their Growth-Inhibitory Effects for Targeted Cancer Immunotherapy

Authors: Sara S Bashraheel, Sayed K Goda

Journal: Int J Mol Sci

PubMed ID: 37445686

Doi: 10.3390/ijms241310507

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Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study

Authors: Jiayou Zhang, Xuanxuan Nian, Bo Liu, Zhegang Zhang, Wei Zhao, Xixin Han, Yumei Ma, Dongwu Jin, Hua Ma, Qingmei Zhang, Ran Qiu, Fang Li, Zheng Gong, Xuedan Li, Ying Yang, Yichao Tian, Li Zhou, Kai Duan, Xinguo Li, Zhongren Ma, Xiaoming Yang

Journal: Antiviral Res

PubMed ID: 37270159

Doi: 10.1016/j.antiviral.2023.105639

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Intact mass analysis reveals the novel O-linked glycosylation on the stalk region of PD-1 protein

Authors: Phanthakarn Tit-Oon, Arisa Wonglangka, Klaichan Boonkanta, Mathuros Ruchirawat, Mayuree Fuangthong, Ram Sasisekharan, Amnart Khongmanee

Journal: Sci Rep

PubMed ID: 37316505

Doi: 10.1038/s41598-023-36203-3

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Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding

Authors: Erik B Faber, Luxin Sun, Jian Tang, Emily Roberts, Sornakala Ganeshkumar, Nan Wang, Damien Rasmussen, Abir Majumdar, Laura E Hirsch, Kristen John, An Yang, Hira Khalid, Jon E Hawkinson, Nicholas M Levinson, Vargheese Chennathukuzhi, Daniel A Harki, Ernst Schönbrunn, Gunda I Georg

Journal: Nat Commun

PubMed ID: 37270540

Doi: 10.1038/s41467-023-38732-x

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Grafting Rhodobacter sphaeroides with red algae Rubisco to accelerate catalysis and plant growth

Authors: Yu Zhou, Laura H Gunn, Rosemary Birch, Inger Andersson, Spencer M Whitney

Journal: Nat Plants

PubMed ID: 37291398

Doi: 10.1038/s41477-023-01436-7

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Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules

Authors: Yanglei Huang, Ziling Ye, Xiukun Wan, Ge Yao, Jingyu Duan, Jiajia Liu, Mingdong Yao, Xiang Sun, Zixin Deng, Kun Shen, Hui Jiang, Tiangang Liu

Journal: Adv Sci (Weinh)

PubMed ID: 37271925

Doi: 10.1002/advs.202300889

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Glutamine synthetase (GS) knockout (KO) using CRISPR/Cpf1 diversely enhances selection efficiency of CHO cells expressing therapeutic antibodies

Authors: Witsanu Srila, Martina Baumann, Markus Riedl, Kuntalee Rangnoi, Nicole Borth, Montarop Yamabhai

Journal: Sci Rep

PubMed ID: 37380701

Doi: 10.1038/s41598-023-37288-6

Products & Services: Proteins, Expression, Isolation and Analysis

An Inferred Ancestral CotA Laccase with Improved Expression and Kinetic Efficiency

Authors: Lei Lei, Lijun Zhao, Yiqia Hou, Chen Yue, Pulin Liu, Yanli Zheng, Wenfang Peng, Jiangke Yang

Journal: Int J Mol Sci

PubMed ID: 37446078

Doi: 10.3390/ijms241310901

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Author Correction: RNA conformational propensities determine cellular activity

Authors: Megan L Ken, Rohit Roy, Ainan Geng, Laura R Ganser, Akanksha Manghrani, Bryan R Cullen, Ursula Schulze-Gahmen, Daniel Herschlag, Hashim M Al-Hashimi

Journal: Nature

PubMed ID: 37296211

Doi: 10.1038/s41586-023-06286-z

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Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation

Authors: Francisco X Galdos, Carissa Lee, Soah Lee, Sharon Paige, William Goodyer, Sidra Xu, Tahmina Samad, Gabriela V Escobar, Adrija Darsha, Aimee Beck, Rasmus O Bak, Matthew H Porteus, Sean M Wu

Journal: Elife

PubMed ID: 37284748

Doi: 10.7554/eLife.80075

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The role of mechano-regulated YAP/TAZ in erectile dysfunction

Authors: Mintao Ji, Dongsheng Chen, Yinyin Shu, Shuai Dong, Zhisen Zhang, Haimeng Zheng, Xiaoni Jin, Lijun Zheng, Yang Liu, Yifei Zheng, Wensheng Zhang, Shiyou Wang, Guangming Zhou, Bingyan Li, Baohua Ji, Yong Yang, Yongde Xu, Lei Chang

Journal: Nat Commun

PubMed ID: 37353497

Doi: 10.1038/s41467-023-39009-z

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Odorant-binding protein 19 in Monochamus alternatus involved in the recognition of a volatile strongly emitted from ovipositing host pines

Authors: Ruinan Yang, Dongzhen Li, Shancheng Yi, Yi Wei, Manqun Wang

Journal: Insect Sci

PubMed ID: 37358042

Doi: 10.1111/1744-7917.13238

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The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins

Authors: Julie Lavie, Claude Lalou, Walid Mahfouf, Jean-William Dupuy, Aurélie Lacaule, Agata Ars Cywinska, Didier Lacombe, Anne-Marie Duchêne, Anne-Aurélie Raymond, Hamid Reza Rezvani, Richard Patryk Ngondo, Giovanni Bénard

Journal: Cell Rep

PubMed ID: 37267103

Doi: 10.1016/j.celrep.2023.112579

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Modularity and diversity of target selectors in Tn7 transposons

Authors: Guilhem Faure, Makoto Saito, Sean Benler, Iris Peng, Yuri I Wolf, Jonathan Strecker, Han Altae-Tran, Edwin Neumann, David Li, Kira S Makarova, Rhiannon K Macrae, Eugene V Koonin, Feng Zhang

Journal: Mol Cell

PubMed ID: 37267947

Doi: 10.1016/j.molcel.2023.05.013

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Performance of commercial SARS-CoV-2 wild-type and Omicron BA1 antibody assays compared with pseudovirus neutralization tests

Authors: E Habermann, L M Frommert, K Ghannam, L Nguyen My, L Gieselmann, P Tober-Lau, J Klotsche, A N Arumahandi de Silva, A Ten Hagen, J Zernicke, F Kurth, L E Sander, F Klein, G R Burmester, R Biesen, F N Albach

Journal: J Clin Virol

PubMed ID: 37354690

Doi: 10.1016/j.jcv.2023.105518

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Negatively charged, intrinsically disordered regions can accelerate target search by DNA-binding proteins

Authors: Xi Wang, Lavi S Bigman, Harry M Greenblatt, Binhan Yu, Yaakov Levy, Junji Iwahara

Journal: Nucleic Acids Res

PubMed ID: 36774964

Doi: 10.1093/nar/gkad045

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Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation

Authors: Xiaoyun Yang , Jiaxu Wang, Simin Li , Xiaobing Li , Jingjing Gong , Zhenzhen Yan , Huan Zhou , Chen Wu , Xiuhua Liu