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Cas9 degradation in human cells using phage anti-CRISPR proteins

Authors: Zuriah Meacham, Luisa Arake de Tacca, Joseph Bondy-Denomy, David Rabuka, Michael Schelle

Journal: PLoS Biol

PubMed ID: 38064533

Doi: 10.1371/journal.pbio.3002431

Products & Services: Molecular Biology Reagents

Anxiety and dysautonomia symptoms in patients with a Na17 mutation and the potential benefits of low-dose short-acting guanfacine

Authors: Rita de Cássia Collaço, Maxime Lammens, Carley Blevins, Kristen Rodgers, Andrei Gurau, Suguru Yamauchi, Christine Kim, Jeannine Forrester, Edward Liu, Jinny Ha, Yuping Mei, Corrine Boehm, Elizabeth Wohler, Nara Sobreira, Peter C Rowe, David Valle, Malcolm V Brock, Frank Bosmans

Journal: Clin Auton Res

PubMed ID: 38064009

Doi: 10.1007/s10286-023-01004-1

Products & Services: Mutant Libraries

High-resolution HLA genotyping in inclusion body myositis refines 81 ancestral haplotype association to DRB1*03:01:01 and highlights pathogenic role of arginine-74 of DRβ1 chain

Authors: Nataliya Slater, Anuradha Sooda, Emily McLeish, Kelly Beer, Anna Brusch, Rakesh Shakya, Christine Bundell, Ian James, Abha Chopra, Frank L Mastaglia, Merrilee Needham, Jerome D Coudert

Journal: J Autoimmun

PubMed ID: 38043487

Doi: 10.1016/j.jaut.2023.103150

Products & Services: Protein and Antibody Isolation

Shank3 ameliorates neuronal injury after cerebral ischemia/reperfusion via inhibiting oxidative stress and inflammation

Authors: Hongchen Zhang, Yuan Feng, Yanfang Si, Chuanhao Lu, Juan Wang, Shiquan Wang, Liang Li, Wenyu Xie, Zheming Yue, Jia Yong, Shuhui Dai, Lei Zhang, Xia Li

Journal: Redox Biol

PubMed ID: 38064762

Doi: 10.1016/j.redox.2023.102983

Products & Services: Protein and Antibody Isolation

Overlapping characteristics of weak interactions of two transcriptional regulators with WDR5

Authors: Mohammad Ahmad, Ali Imran, Liviu Movileanu

Journal: Int J Biol Macromol

PubMed ID: 38158065

Doi: 10.1016/j.ijbiomac.2023.128969

Products & Services: Protein and Antibody Isolation

Anti-inflammatory effects of neuregulin-1 in HaCaT keratinocytes and atopic dermatitis-like mice stimulated with Der p 38

Authors: Jeong Hee Yun, Yujin Hong, Min Hwa Hong, Geunyeong Kim, Ji-Sook Lee, Ran-Sook Woo, Juram Lee, Eun Ju Yang, In Sik Kim

Journal: Cytokine

PubMed ID: 38134557

Doi: 10.1016/j.cyto.2023.156439

Products & Services: Molecular Biology Reagents

Bivalent inhibitors of the BTB E3 ligase KEAP1 enable instant NRF2 activation to suppress acute inflammatory response

Authors: Mengchen Lu, Jianai Ji, Yifei Lv, Jing Zhao, Yuting Liu, Qiong Jiao, Tian Liu, Yi Mou, Qidong You, Zhengyu Jiang

Journal: Cell Chem Biol

PubMed ID: 38157852

Doi: 10.1016/j.chembiol.2023.12.005

Products & Services: PCR Cloning and Subcloning

Screening of novel DPP-IV inhibitory peptides derived from bovine milk proteins using a peptide array platform

Authors: Sayuri Arai, Masaki Kurimoto, Hajime Nakada, Masayoshi Tanaka, Hiroshi Ochi, Miyuki Tanaka, Mina Okochi

Journal: J Biosci Bioeng

PubMed ID: 38092600

Doi: 10.1016/j.jbiosc.2023.11.007

Products & Services: Catalog Peptides

Template and target-site recognition by human LINE-1 in retrotransposition

Authors: Akanksha Thawani, Alfredo Jose Florez Ariza, Eva Nogales, Kathleen Collins

Journal: Nature

PubMed ID: 38096901

Doi: 10.1038/s41586-023-06933-5

Products & Services: Molecular Biology Reagents

Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding

Authors: Fanchong Jian, Leilei Feng, Sijie Yang, Yuanling Yu, Lei Wang, Weiliang Song, Ayijiang Yisimayi, Xiaosu Chen, Yanli Xu, Peng Wang, Lingling Yu, Jing Wang, Lu Liu, Xiao Niu, Jing Wang, Tianhe Xiao, Ran An, Yao Wang, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Youchun Wang, Xiangxi Wang, Yunlong Cao

Journal: PLoS Pathog

PubMed ID: 38117863

Doi: 10.1371/journal.ppat.1011868

Products & Services: Protein and Antibody Isolation

Plant-based meat analogues enhance the gastrointestinal motility function and appetite of mice by specific volatile compounds and peptides

Authors: Yunting Xie, Linlin Cai, Mengzhen Ding, Kai Shan, Di Zhao, Guanghong Zhou, Chunbao Li

Journal: Food Research International

Doi: 10.1016/j.foodres.2023.113551

Products & Services: Gene Synthesis

Biguanide chitosan microneedles with cell-free DNA scavenging ability for psoriasis therapy

Authors: Zihao Liu , Yu Wang , Yuhan Zhang , Liufu Hu , Bozhi Chen , Yang Li , Xindong Guo , Bingran Yu , Fu-Jian Xu

Journal: Bioactive Materials

Doi: 10.1016/j.bioactmat.2023.11.015

Products & Services: Gene Synthesis

Synthetic High-Density Lipoprotein-Based Nanomedicine to Silence SOCS1 in Tumor Microenvironment and Trigger Antitumor Immunity against Glioma

Authors: Chunrong Yang , Yujie Li , Yuchen Yang , Qiankun Ni , Zeyu Zhang , Yi Chai , Jinghong Li

Journal: Angew Chem Int Ed Engl .

PubMed ID: 37847126

Doi: 10.1002/anie.202312603

Products & Services: Peptide Synthesis

A KDPG sensor RccR governs Pseudomonas aeruginosa carbon metabolism and aminoglycoside antibiotic tolerance

Authors: Yujue Wang , Zhipeng Wang , Weizhong Chen , Ze-Hui Ren , Hui Gao , Jiani Dai , Guan-Zheng Luo , Zhaowei Wu , Quanjiang Ji

Journal: Nucleic Acids Res .

PubMed ID: 38096062

Doi: 10.1093/nar/gkad1201

Products & Services: Molecular Biology Reagents

Shenqi Fuzheng injection restores the sensitivity to gefitinib in non-small cell lung cancer by inhibiting the IL-22 STAT3 AKT pathway

Authors: Jiali Wang , Xianhai He , Zhirong Jia , Aiwen Yan , Kang Xiao , Shuo Liu , Mengjun Hou , Yaling Long , Xuansheng Ding

Journal: Pharm Biol .

PubMed ID: 38100532

Doi: 10.1080/13880209.2023.2292266

Products & Services: PCR Cloning and Subcloning

Structure and mechanism of a eukaryotic ceramide synthase complex

Authors: Tian Xie , Qi Fang , Zike Zhang , Yanfei Wang , Feitong Dong , Xin Gong

Journal: EMBO J .

PubMed ID: 37953642

Doi: 10.15252/embj.2023114889

Products & Services: Protein and Antibody Isolation

The nuclease-associated short prokaryotic Argonaute system nonspecifically degrades DNA upon activation by target recognition

Authors: Xueling Lu, Jun Xiao, Longfei Wang, Bin Zhu, Fengtao Huang

Journal: Nucleic Acids Res

PubMed ID: 38048327

Doi: 10.1093/nar/gkad1145

Products & Services: Protein and Antibody Isolation

Authors: Ewa Hordyjewska-Kowalczyk, Wim Wuyts, Nele Boeckx, An Verdonck, Gretl Hendrickx, Geert Mortier

Journal: Clin Genet

PubMed ID: 38108099

Doi: 10.1111/cge.14474

Products & Services: Protein and Antibody Isolation

Differential activation of mouse and human Panx1 channel variants

Authors: Antonio Cibelli, Preeti Dohare, David C Spray, Eliana Scemes

Journal: PLoS ONE

PubMed ID: 38100403

Doi: 10.1371/journal.pone.0295710

Products & Services: Protein and Antibody Isolation

A randomized phase II study of acyclovir for the prevention of chemotherapy-induced oral mucositis in patients undergoing autologous hematopoietic stem cell transplantation

Authors: Junshik Hong, Hee-Kyung Park, Sung-Ho Chang, Ja Min Byun, Dong-Yeop Shin, Youngil Koh, Sung-Soo Yoon, Youngnim Choi, Inho Kim

Journal: BMC Oral Health

PubMed ID: 38102638

Doi: 10.1186/s12903-023-03623-6

Products & Services: Protein and Antibody Isolation

The global transcription regulator XooClp governs Type IV pili system mediated bacterial virulence by directly binding to their promoters to coordinate virulence associated functions

Authors: Raj Kumar Verma, Parimala Gondu, Tirthankar Saha, Subhadeep Chatterjee

Journal: Mol Plant Microbe Interact

PubMed ID: 38105438

Doi: 10.1094/MPMI-07-23-0100-R

Products & Services: Protein and Antibody Isolation

Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ25 complexes in the context of celiac disease

Authors: Yuu Okura, Yuri Ikawa-Teranishi, Akihiko Mizoroki, Noriyuki Takahashi, Takashi Tsushima, Machiko Irie, Zulkarnain Harfuddin, Momoko Miura-Okuda, Shunsuke Ito, Genki Nakamura, Hiroaki Takesue, Yui Ozono, Masamichi Nishihara, Kenta Yamada, Siok Wan Gan, Akira Hayasaka, Shinya Ishii, Tetsuya Wakabayashi, Masaru Muraoka, Nishiki Nagaya, Hiroshi Hino, Takayuki Nemoto, Taichi Kuramochi, Takuya Torizawa, Hideaki Shimada, Takehisa Kitazawa, Makoto Okazaki, Junichi Nezu, Ludvig M Sollid, Tomoyuki Igawa

Journal: Nat Commun

PubMed ID: 38135691

Doi: 10.1038/s41467-023-44083-4

Products & Services: Peptide Synthesis

ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape

Authors: Tianyao Liu, Xinyan Xu, Jiazheng Li, Ming Bai, Wenjie Zhu, Yanqing Liu, Siyang Liu, Zihan Zhao, Tianhang Li, Ning Jiang, Yuhao Bai, Qingyang Jin, Yulin Zhang, Yufeng Zheng, Shengkai Zhou, Shoubin Zhan, Ying Sun, Gaoli Liang, Yang Luo, Xi Chen, Hongqian Guo, Rong Yang

Journal: Cell Death Dis

PubMed ID: 38062004

Doi: 10.1038/s41419-023-06333-7

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Acid phosphatase-like proteins, a biogenic amine and leukotriene-binding salivary protein family from the flea Xenopsylla cheopis

Authors: Stephen Lu, John F Andersen, Christopher F Bosio, B Joseph Hinnebusch, José M Ribeiro

Journal: Commun Biol

PubMed ID: 38110569

Doi: 10.1038/s42003-023-05679-0

Products & Services: Recombinant Proteins

Bioinformatics analyses of infiltrating immune cell participation on pancreatic ductal adenocarcinoma progression and in vivo experiment of the therapeutic effect of Shuangshen granules

Authors: Jiaqi Hu, Juling Jiang, Bowen Xu, Yue Li, Bei Wang, Shulin He, Xiaoling Ren, Bolun Shi, Xing Zhang, Honggang Zheng, Baojin Hua, Rui Liu

Journal: J Ethnopharmacol

PubMed ID: 38113986

Doi: 10.1016/j.jep.2023.117590

Products & Services: Protein and Antibody Isolation

Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients

Authors: Jean-Pierre Bellier, Yuqi Cai, Sarah M Alam, Thorsten Wiederhold, Arica Aiello, Jonathan S Vogelgsang, Sabina Berretta, Jasmeer P Chhatwal, Dennis J Selkoe, Lei Liu

Journal: Alzheimers Dement

PubMed ID: 38041855

Doi: 10.1002/alz.13557

Products & Services: Protein Electrophoresis and Western

Protocol for precision editing of endogenous Chlamydomonas reinhardtii genes with CRISPR-Cas

Authors: Adrian Pascal Nievergelt, Dennis Ray Diener, Aliona Bogdanova, Thomas Brown, Gaia Pigino

Journal: STAR Protoc

PubMed ID: 38096061

Doi: 10.1016/j.xpro.2023.102774

Products & Services: CRISPR Plasmids

Agonistic Bivalent Human scFvs-Fcγ Fusion Antibodies to OX40 Ectodomain Enhance T Cell Activities against Cancer

Authors: Kodchakorn Mahasongkram, Kantaphon Glab-Ampai, Kanasap Kaewchim, Thanatsaran Saenlom, Monrat Chulanetra, Nitat Sookrung, Oytip Nathalang, Wanpen Chaicumpa

Journal: Vaccines (Basel)

PubMed ID: 38140230

Doi: 10.3390/vaccines11121826

Products & Services: Recombinant Proteins

Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs

Authors: Wenyan Han, Hou-Yuan Qiu, Shangwu Sun, Zhi-Can Fu, Guo-Quan Wang, Xiaowen Qian, Lijie Wang, Xiaowen Zhai, Jia Wei, Yichuan Wang, Yi-Lin Guo, Guo-Hua Cao, Rui-Jin Ji, Yi-Zhou Zhang, Hongxia Ma, Hongsheng Wang, Mingli Zhao

Journal: Cell Stem Cell

PubMed ID: 37989316

Doi: 10.1016/j.stem.2023.10.007

Products & Services: Protein and Antibody Isolation

Glucose-primed PEEK orthopedic implants for antibacterial therapy and safeguarding diabetic osseointegration

Authors: Miaomiao He, Hao Wang, Qiuyang Han, Xiuyuan Shi, Shuai He, Jiyu Sun, Zhuoli Zhu, Xueqi Gan, Yi Deng

Journal: Biomaterials

PubMed ID: 37948855

Doi: 10.1016/j.biomaterials.2023.122355

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Neuroprotective Effects of N-methyl-(2S, 4R)-trans-4-hydroxy-L-proline (NMP) against Amyloid-β-Induced Alzheimer's Disease Mouse Model

Authors: Jawad Ali, Amjad Khan, Jun Sung Park, Muhammad Tahir, Waqas Ahmad, Kyonghwan Choe, Myeong Ok Kim

Journal: Nutrients

PubMed ID: 38068844

Doi: 10.3390/nu15234986

Products & Services: Peptide Synthesis

Infliximab aggregates produced in severe and mild elevated temperature stress conditions induce an extended specific CD4 T-cell response

Authors: Myriam Nabhan, Sylvain Meunier, Victor Le-Minh, Baptiste Robin, Marie de Bourayne, Claire Smadja, Bernard Maillère, Marc Pallardy, Isabelle Turbica

Journal: Eur J Pharm Sci

PubMed ID: 38070782

Doi: 10.1016/j.ejps.2023.106670

Products & Services: Protein and Antibody Isolation

A bead-based multiplex assay covering all coronaviruses pathogenic for humans for sensitive and specific surveillance of SARS-CoV-2 humoral immunity

Authors: Daniel Stern, Tanja C Meyer, Fridolin Treindl, Hans Werner Mages, Maren Krüger, Martin Skiba, Jan Philipp Krüger, Christian M Zobel, Maximilian Schreiner, Marica Grossegesse, Thomas Rinner, Caroline Peine, Anna Stoliaroff-Pépin, Thomas Harder, Natalie Hofmann, Janine Michel, Andreas Nitsche, Silke Stahlberg, Antje Kneuer, Anna Sandoni, Ulrike Kubisch, Martin Schlaud, Annette Mankertz, Tatjana Schwarz, Victor M Corman, Marcel A Müller, Christian Drosten, Kathrin de la Rosa, Lars Schaade, Martin B Dorner, Brigitte G Dorner

Journal: Sci Rep

PubMed ID: 38071261

Doi: 10.1038/s41598-023-48581-9

Products & Services: ELISA Kits

Gene-based COVID-19 vaccines: Australian perspectives in a corporate and global context

Authors: Peter Rhodes, Peter Parry

Journal: Pathol Res Pract

PubMed ID: 38101158

Doi: 10.1016/j.prp.2023.155030

Products & Services: Protein and Antibody Isolation

Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma and identifies matrix-activated therapeutic targets

Authors: Ricardo Cruz-Acuña, Secunda W Kariuki, Kensuke Sugiura, Spyros Karaiskos, Eleanor M Plaster, Claudia Loebel, Gizem Efe, Tatiana Karakasheva, Joel T Gabre, Jianhua Hu, Jason A Burdick, Anil K Rustgi

Journal: J Clin Invest

PubMed ID: 37788109

Doi: 10.1172/JCI168146

Products & Services: Peptide Synthesis

α-Synuclein emulsifies TDP-43 prion-like domain-RNA liquid droplets to promote heterotypic amyloid fibrils

Authors: Shailendra Dhakal, Malay Mondal, Azin Mirzazadeh, Siddhartha Banerjee, Ayanjeet Ghosh, Vijayaraghavan Rangachari

Journal: Commun Biol

PubMed ID: 38052886

Doi: 10.1038/s42003-023-05608-1

Products & Services: Protein and Antibody Isolation

Redeveloping antigen detection kits for the diagnosis of rat hepatitis E virus

Authors: Zihao Chen, Guanghui Li, Jianwen Situ, Zhiyong Li, Shaoqi Guo, Yang Huang, Shusheng Wu, Zimin Tang, Guiping Wen, Siling Wang, Mujin Fang, Yingbin Wang, Hai Yu, Siddharth Sridhar, Zizheng Zheng, Ningshao Xia

Journal: J Clin Microbiol

PubMed ID: 38038482

Doi: 10.1128/jcm.00710-23

Products & Services: Molecular Biology Reagents

An evolutionarily conserved serine protease network mediates melanization and Toll activation in

Authors: Tisheng Shan, Yang Wang, Krishna Bhattarai, Haobo Jiang

Journal: Sci Adv

PubMed ID: 38117884

Doi: 10.1126/sciadv.adk2756

Products & Services: Protein and Antibody Isolation

Mezigdomide is effective alone and in combination with Menin inhibition in pre-clinical models of KMT2A-r and NPM1c AML

Authors: Wallace Bourgeois, Jevon A Cutler, Brandon J Aubrey, Daniela Wenge, Florian Perner, Cynthia Martucci, Jill A Henrich, Kelly Klega, Radoslaw P Nowak, Katherine Aleisha Donovan, Meaghan Boileau, Yanhe Wen, Charles Hatton, Athina A Apazidis, Sarah N Olsen, Nadia Kirmani, Yana Pikman, Jessica A Pollard, Jennifer A Perry, Adam S Sperling, Benjamin L Ebert, Gerard M McGeehan, Brian D Crompton, Eric S Fischer, Scott A Armstrong

Journal: Blood

PubMed ID: 38096371

Doi: 10.1182/blood.2023021105

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A plasmid containing the human metallothionein-II gene selectively distinguishes trivalent lanthanum from several divalent heavy metal cations during monoclonal antibody-assisted agarose gel electrophoresis

Authors:

Journal: Toxicol Ind Health

PubMed ID: 38095284

Doi: 10.1177/07482337231222354

Products & Services: Molecular Biology Reagents

Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16

Authors: Huan Wang, Syed R A Rizvi, Danni Dong, Jiaqi Lou, Qian Wang, Watanyoo Sopipong, Yufeng Su, Fares Najar, Pratul K Agarwal, Frank Kozielski, Shozeb Haider

Journal: Elife

PubMed ID: 38127066

Doi: 10.7554/eLife.87884

Products & Services: Protein and Antibody Isolation

Activation and characterization of G protein-coupled receptors for CHHs in the mud crab, Scylla paramamosain

Authors: Nan Mo, Shucheng Shao, Yan Zhuang, Yanan Yang, Zhaoxia Cui, Chenchang Bao

Journal: Comp Biochem Physiol A Mol Integr Physiol

PubMed ID: 38122925

Doi: 10.1016/j.cbpa.2023.111563

Products & Services: Protein and Antibody Isolation

Efficient de novo production of bioactive cordycepin by Aspergillus oryzae using a food-grade expression platform

Authors: Sukanya Jeennor, Jutamas Anantayanon, Sarocha Panchanawaporn, Chanikul Chutrakul, Wanwipa Vongsangnak, Kobkul Laoteng

Journal: Microb Cell Fact

PubMed ID: 38071331

Doi: 10.1186/s12934-023-02261-5

Products & Services: Molecular Biology Reagents

Diverse nature of ClpX degradation motifs in

Authors: Vivek Gurung, Saswati Biswas, Indranil Biswas

Journal: Microbiol Spectr

PubMed ID: 38051052

Doi: 10.1128/spectrum.03457-23

Products & Services: Protein and Antibody Isolation

The OsBZR1-OsSPX1/2 Module Fine-tunes Growth-Immunity Trade-off in Adaptation to Pi Availability in Rice

Authors: Yuqing He , Yao Zhao , Jitao Hu , Lanlan Wang , Linying Li , Xueying Zhang , Zhongjing Zhou , Lili Chen , Hua Wang , Jiaoyu Wang , Gaojie Hong

Journal: Mol Plant .

PubMed ID: 38069474

Doi: 10.1016/j.molp.2023.12.003

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Anti-virulence and bactericidal activities of Stattic against Shigella sonnei

Authors: Mingfang Wang, Jia Zeng, Huihui Tan, Quan Guo, Xia Li, Xiwen Ling, Jinyue Zhang, Shihao Song, Yinyue Deng

Journal: Appl Environ Microbiol .

PubMed ID: 38032177

Doi: 10.1128/aem.01074-23

Products & Services: Protein and Antibody Isolation

A General and Convenient Peptide Self-Assembling Mechanism for Developing Supramolecular Versatile Nanomaterials Based on The Biosynthetic Hybrid Amyloid-Resilin Protein

Authors: Junjun Wu, Lin Zhou, Hu Peng, Zhaojun Wang, Zhaoshi Wang, Jay D Keasling, Shike Liu, Guanghong Zhou, Shijie Ding, Qiong Wang, Xuejian Wang, Xinxiu Chen, Yifei Lang, Mo Xia, Xin Guan, Mingsheng Dong, Jingwen Zhou, Jian Chen

Journal: Adv Mater

PubMed ID: 37885340

Doi: 10.1002/adma.202304364

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Immunogenicity Persistence of a Third-Dose Homologous BBIBP-CorV/CoronaVac Boosting Vaccination: A Prospective Open-Label Study

Authors: Na Ren, Zhihong Wang, Sikang Gao

Journal: Viral Immunol

PubMed ID: 38109058

Doi: 10.1089/vim.2023.0075

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The egg ribonuclease SjCP1412 accelerates liver fibrosis caused by infection involving damage-associated molecular patterns (DAMPs)

Authors: Qi-Feng Li, Yi-Xin Li, Ying-Ying Yang, Pan-Pan Dong, Cong-Jin Mei, Ju-Lu Lu, Jian-Feng Zhang, Hai-Yong Hua, Chun-Rong Xiong, Chuan-Xin Yu, Li-Jun Song, Kun Yang

Journal: Parasitology

PubMed ID: 38105713

Doi: 10.1017/S0031182023001361

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Worsening of imiquimod-induced psoriasiform inflammation in mice by environmental pollutant, di-(2-ethylhexyl) phthalate through dysregulation in IL-17A and Nrf2/iNOS signaling in peripheral myeloid and CD4 + T cells

Authors: Ali S Alfardan, Ahmed Nadeem, Sheikh F Ahmad, Naif O Al-Harbi, Mohammed Alqinyah, Sabry M Attia, Wedad Sarawi, Ahmed Z Alanazi, Khalid Alhazzani, Khalid E Ibrahim

Journal: Int Immunopharmacol

PubMed ID: 38056199

Doi: 10.1016/j.intimp.2023.111293

Products & Services: PCR Cloning and Subcloning

Pro-osteogenic role of interleukin-22 in calcific aortic valve disease

Authors: Huifang Deng, Huadong Li, Zongtao Liu, Na Shen, Nianguo Dong, Cheng Deng, Fayuan Liu

Journal: Atherosclerosis

PubMed ID: 38104486

Doi: 10.1016/j.atherosclerosis.2023.117424

Products & Services: Protein Electrophoresis and Western

Resveratrol-derived inhibitors of the E3 ubiquitin ligase PELI1 inhibit the metastasis of triple-negative breast cancer

Authors: Guangsen Xu, Qian Zhou, Jie Qi, Zhongyue Li, Lijun Yin, Zhuoran Li, Chunhua Lu, Baobing Zhao, Yuemao Shen

Journal: Eur J Med Chem

PubMed ID: 38150964

Doi: 10.1016/j.ejmech.2023.116060

Products & Services: PCR Cloning and Subcloning

The density of anionic lipids modulates the adsorption of α-Synuclein onto lipid membranes

Authors: Alexandra Andersson, Sara Linse, Emma Sparr, Marco Fornasier, Peter Jönsson

Journal: Biophys Chem

PubMed ID: 38100855

Doi: 10.1016/j.bpc.2023.107143

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Metabolic signatures of tear extracellular vesicles caused by herpes simplex keratitis

Authors: Huixiang Ma, Tucan Chen, Chengxu Li, Hao Xu, Qingyu Feng, Yunfei Su, Jianqiu Cai, Qingfu Zhu, Fei Liu, Liang Hu

Journal: Ocul Surf

PubMed ID: 38122863

Doi: 10.1016/j.jtos.2023.12.005

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Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways

Authors: Qiao Liu, Qingman Luo, Bin Zhong, Kecheng Tang, Xueling Chen, Shengqian Yang, Xiaohui Li

Journal: Eur J Pharmacol

PubMed ID: 38048979

Doi: 10.1016/j.ejphar.2023.176236

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Akt may associate with insulin-responsive vesicles via interaction with sortilin

Authors: Nava Zaarur, Anatoli B Meriin, Maneet Singh, Raghuveera K Goel, Joseph Zaia, Konstantin V Kandror

Journal: FEBS Lett

PubMed ID: 38105115

Doi: 10.1002/1873-3468.14790

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The potential of lactose to inhibit cereulide biosynthesis of emetic Bacillus cereus in milk

Authors: Yin Zheng, Wenxing Xu, Hui Guo, Shubo Yu, Liang Xue, Moutong Chen, Jumei Zhang, Zhenlin Xu, Qingping Wu, Juan Wang, Yu Ding

Journal: Int J Food Microbiol

PubMed ID: 38096676

Doi: 10.1016/j.ijfoodmicro.2023.110517

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Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion

Authors: Chaoran Xu, Qia Zhang, Yi Zhang, Huaijun Chen, Tianchi Tang, Junjie Wang, Siqi Xia, Gao Chen, Jianmin Zhang

Journal: J Neuroinflammation

PubMed ID: 38071333

Doi: 10.1186/s12974-023-02980-x

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Development of a rapid assay for β-etherase activity using a novel chromogenic substrate

Authors: Itzel Celeste Romero-Soto, Jorge A Rodríguez, Vicente Paúl Armenta-Pérez, Raúl Balam Martínez-Pérez, Rosa María Camacho-Ruiz, Leociley Rocha Alencar Menezes, Guilherme Lanzi Sassaki, Arquimedes Santana-Filho, María Angeles Camacho-Ruiz

Journal: Talanta

PubMed ID: 38091749

Doi: 10.1016/j.talanta.2023.125501

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High-fidelity large-diversity monoclonal mammalian cell libraries by cell cycle arrested recombinase-mediated cassette exchange

Authors: Chuan Chen, Zening Wang, Minhyo Kang, Ki Baek Lee, Xin Ge

Journal: Nucleic Acids Res

PubMed ID: 37941133

Doi: 10.1093/nar/gkad1001

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In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma

Authors: Qiang Cheng, Lukas Farbiak, Amogh Vaidya, Erick Guerrero, Eunice E Lee, Elysha K Rose, Xu Wang, Joshua Robinson, Sang M Lee, Tuo Wei, William E Miller, Ester Alvarez Benedicto, Xizhen Lian, Richard C Wang, Daniel J Siegwart

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38109533

Doi: 10.1073/pnas.2313009120

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Crystal structure of ricin toxin A chain complexed with a highly potent pterin-based small-molecular inhibitor

Authors: Masaru Goto, Natsumi Sakamoto, Shoko Higashi, Rena Kawata, Kazuki Nagatsu, Ryota Saito

Journal: J Enzyme Inhib Med Chem

PubMed ID: 37259593

Doi: 10.1080/14756366.2023.2219038

Products & Services: Protein and Antibody Isolation

Bu-Shen-Tian-Jing formulas alleviate the mitochondrial damage induced by oxidative stress in ovarian granulosa cells exposed to DEHP through the HDAC3-HSP90AA pathway

Authors: Hui Zhang, Huihua Wang, Qing Zhang, Hui Wang, Yuhang Zhu, Fangfang Wang, Jun Lin, Jue Zhou, Fan Qu

Journal: Pharm Biol

PubMed ID: 37655754

Doi: 10.1080/13880209.2023.2249193

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Chromosome recombination and modification by LoxP-mediated evolution in Vibrio natriegens using CRISPR-associated transposases

Authors: Jiaqi Xu, Yijie Sun, Jianping Wu, Sheng Yang, Lirong Yang

Journal: Biotechnol Bioeng

PubMed ID: 38131162

Doi: 10.1002/bit.28639

Products & Services: Gene Synthesis

SAXS/WAXS data of conformationally flexible ribose binding protein

Authors: Jagrity Choudhury, Kento Yonezawa, Anu Anu, Nobutaka Shimizu, Barnali Chaudhuri

Journal: Data Brief

PubMed ID: 38178847

Doi: 10.1016/j.dib.2023.109932

Products & Services: Molecular Biology Reagents

A naturally occurring HA-stabilizing amino acid (HA1-Y17) in an A(H9N2) low-pathogenic influenza virus contributes to airborne transmission

Authors: Xiangjie Sun, Jessica A Belser, Joanna A Pulit-Penaloza, Nicole Brock, Troy J Kieran, Hui Zeng, Claudia Pappas, Terrence M Tumpey, Taronna R Maines

Journal: MBio

PubMed ID: 38112470

Doi: 10.1128/mbio.02957-23

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Discovery of GPX4 inhibitors through FP-based high-throughput screening

Authors: Yu Cao, Bin Wu, Ying Xu, Mingchen Wang, Xinyu Wu, Xiaochen Liang, Jin Lin, Zhihai Li, Hua Lin, Cheng Luo, Shijie Chen

Journal: Eur J Med Chem

PubMed ID: 38145603

Doi: 10.1016/j.ejmech.2023.116044

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HERPUD1 governs tumor cell mitochondrial function via inositol 1,4,5-trisphosphate receptor-mediated calcium signaling

Authors: Felipe Paredes, Mario Navarro-Marquez, Clara Quiroga, Danica Jiménez-Gallegos, Samantha M Yeligar, Valentina Parra, Marioly Müller, Mario Chiong, Andrew F G Quest, Alejandra San Martin, Sergio Lavandero

Journal: Free Radic Biol Med

PubMed ID: 38043868

Doi: 10.1016/j.freeradbiomed.2023.11.022

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Photosensitizer-singlet oxygen sensor conjugated silica nanoparticles for photodynamic therapy and bioimaging

Authors: Jeladhara Sobhanan, Kenji Ono, Takuya Okamoto, Makoto Sawada, Paul S Weiss, Vasudevanpillai Biju

Journal: Chem Sci

PubMed ID: 38332815

Doi: 10.1039/d3sc03877g

Products & Services: Molecular Biology Reagents

Circ_0000115 Protects Against Cerebral Ischemia Injury by Suppressing Neuronal Apoptosis, Oxidative Stress and Inflammation by miR-1224-5p/Nos3 Axis In Vitro

Authors: Ying Cao, Yanbing Xu, Rui Zhang, Junsheng Qi, Qiuyu Su, Zhiqiang Chen

Journal: Mol Biotechnol

PubMed ID: 38151617

Doi: 10.1007/s12033-023-01005-5

Products & Services: Molecular Biology Reagents

Antibodies to D7L salivary proteins as a new serological tool to estimate human exposure to mosquitoes

Authors: Sophana Chea, Laura Willen, Sreynik Nhek, Piseth Ly, Kristina Tang, James Oristian, Roberto Salas-Carrillo, Aiyana Ponce, Paola Carolina Valenzuela Leon, Dara Kong, Sokna Ly, Ratanak Sath, Chanthap Lon, Rithea Leang, Rekol Huy, Christina Yek, Jesus G Valenzuela, Eric Calvo, Jessica E Manning, Fabiano Oliveira

Journal: medrxiv

PubMed ID: 38318204

Doi: 10.1101/2023.12.22.23300438

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Cell cycle status of male and female gametes during Arabidopsis reproduction

Authors: Yoav Voichek, Bohdana Hurieva, Caroline Michaud, Anna Schmücker, Zaida Vergara, Bénédicte Desvoyes, Crisanto Gutierrez, Viktoria Nizhynska, Benjamin Jaegle, Michael Borg, Frédéric Berger, Magnus Nordborg, Mathieu Ingouff

Journal: Plant Physiol

PubMed ID: 37757882

Doi: 10.1093/plphys/kiad512

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Targeted mutagenesis of the β-strand DNA binding region of African swine fever virus histone-like protein (pA104R) impairs DNA-binding activity and antibody recognition

Authors: Ana Catarina Urbano, Nicolas Ferreira, Nuno Jordão, Fernando Boinas, Carlos Martins, Fernando Ferreira

Journal: Antiviral Res

PubMed ID: 38103699

Doi: 10.1016/j.antiviral.2023.105784

Products & Services: Molecular Biology Reagents

Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization

Authors: Tong Ye, Zhouguang Jiao, Xin Li, Zhanlong He, Yanyan Li, Fengmei Yang, Xin Zhao, Youchun Wang, Weijin Huang, Meng Qin, Yingmei Feng, Yefeng Qiu, Wenhui Yang, Lingfei Hu, Yaling Hu, Yu Zhai, Erqiang Wang, Di Yu, Shuang Wang, Hua Yue, Yishu Wang, Hengliang Wang, Li Zhu, Guanghui Ma, Wei Wei

Journal: Nature

PubMed ID: 38093012

Doi: 10.1038/s41586-023-06809-8

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The p30 protein of the African swine fever virus behaves as an RNase

Authors: Satyendu Nandy, Nilave Ranjan Bora, Shubham Gaurav, Sachin Kumar

Journal: Virology

PubMed ID: 38086285

Doi: 10.1016/j.virol.2023.109967

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Suppression of overactive IGF-1 attenuates trauma-induced heterotopic ossification in mice

Authors: Dong Mao, Kai Wang, Hong Jiang, Jingyi Mi, Xiaoyun Pan, Gang Zhao, Yongjun Rui

Journal: Am J Pathol

PubMed ID: 38101566

Doi: 10.1016/j.ajpath.2023.11.012

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Functional divergence of a bacterial enzyme promotes healthy or acneic skin

Authors: Irshad A Hajam, Madhusudhanarao Katiki, Randall McNally, María Lázaro-Díez, Stacey Kolar, Avradip Chatterjee, Cesia Gonzalez, Mousumi Paulchakrabarti, Biswa Choudhury, J R Caldera, Trieu Desmond, Chih-Ming Tsai, Xin Du, Huiying Li, Ramachandran Murali, George Y Liu

Journal: Nat Commun

PubMed ID: 38052825

Doi: 10.1038/s41467-023-43833-8

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High levels of alpha-gal with large variation in the salivary glands of lone star ticks fed on human blood

Authors: L Paulina Maldonado-Ruiz, Kathryn E Reif, Anuradha Ghosh, Stephanie Foré, Rachel L Johnson, Yoonseong Park

Journal: Sci Rep

PubMed ID: 38049505

Doi: 10.1038/s41598-023-48437-2

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Publisher Correction: CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides

Authors: Guillaume Gaud, Sooraj Achar, François X P Bourassa, John Davies, Teri Hatzihristidis, Seeyoung Choi, Taisuke Kondo, Selamawit Gossa, Jan Lee, Paul Juneau, Naomi Taylor, Christian S Hinrichs, Dorian B McGavern, Paul François, Grégoire Altan-Bonnet, Paul E Love

Journal: Nat Immunol

PubMed ID: 38057618

Doi: 10.1038/s41590-023-01725-5

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Generation and Characterization of SORT1-Targeted Antibody-Drug Conjugate for the Treatment of SORT1-Positive Breast Tumor

Authors: Weiliang Zhuang, Wei Zhang, Liping Xie, Lei Wang, Yuan Li, Ziyu Wang, Ao Zhang, Haitao Qiu, Jun Feng, Baohong Zhang, Youjia Hu

Journal: Int J Mol Sci

PubMed ID: 38139459

Doi: 10.3390/ijms242417631

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Elucidation of the structural basis for ligand binding and translocation in conserved insect odorant receptor co-receptors

Authors: Jody Pacalon, Guillaume Audic, Justine Magnat, Manon Philip, Jérôme Golebiowski, Christophe J Moreau, Jérémie Topin

Journal: Nat Commun

PubMed ID: 38081900

Doi: 10.1038/s41467-023-44058-5

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Enhancing CAR-T cells: unleashing lasting impact potential with phytohemagglutinin activation in in vivo leukemia model

Authors: Berranur Sert, Gamze Gulden, Tarik Teymur, Yasin Ay, Raife Dilek Turan, Onur Mert Unaldi, Elanur Guzenge, Hamza Emir Erdil, Sevim Isik, Pinar Oz, Ilknur Bozkurt, Samed Ozer, Tahire Yurdakul, Osman Kamali, Ercument Ovali, Nevzat Tarhan, Cihan Tastan

Journal: Cancer Gene Ther

PubMed ID: 38092962

Doi: 10.1038/s41417-023-00709-9

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Targeted mutagenesis of the herpesvirus fusogen central helix captures transition states

Authors: Momei Zhou, Benjamin Vollmer, Emily Machala, Muyuan Chen, Kay Grünewald, Ann M Arvin, Wah Chiu, Stefan L Oliver

Journal: Nat Commun

PubMed ID: 38042814

Doi: 10.1038/s41467-023-43011-w

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Structural basis of branching during RNA splicing

Authors: Daniel B Haack, Boris Rudolfs, Cheng Zhang, Dmitry Lyumkis, Navtej Toor

Journal: Nat Struct Mol Biol

PubMed ID: 38057551

Doi: 10.1038/s41594-023-01150-0

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Immunoswitch Nanomodulators Enable Active Targeting and Selective Proliferation of Regulatory T Cells for Multiple Sclerosis Therapy

Authors: Xiaoshuang Wang , Zhilin Liu , Di Wang , Yingyu Zhang , Honglei Zhang , Fuxin Xue , Xianhong Wang , Zhaohui Tang , Xuemei Han

Journal: ACS Nano .

PubMed ID: 38113242

Doi: 10.1021/acsnano.3c09225

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Ferricyanide-promoted Oxidative Activation and Ligation of Protein Thioacids in Neutral Aqueous Media

Authors: Guo-Chao Chu, Lu-Jun Liang, Rui Zhao, Yan-Yan Guo, Chun-Tong Li, Chong Zuo, Huasong Ai, Xiao Hua, Zi-Chen Li, Yi-Ming Li, Lei Liu

Journal: CCS Chemistry

Doi: 10.31635/ccschem.023.202303397

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JH degradation pathway participates in hormonal regulation of larval development of Bombyx mori following λ-cyhalothrin exposure

Authors: Yue Su, Wanwan Wang, Yixin Dai, Ruinan Qi, Haoyi Gu, Xiqian Guo, Xinyu Liu, Yuying Ren, Fanchi Li, Bing Li, Haina Sun

Journal: Chemosphere

PubMed ID: 38056714

Doi: 10.1016/j.chemosphere.2023.140871

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Surrogate Virus Neutralisation Test Based on Nanoluciferase-Tagged Antigens to Quantify Inhibitory Antibodies against SARS-CoV-2 and Characterise Omicron-Specific Reactivity in a Vaccination Cohort

Authors: Michael Schoefbaenker, Rieke Neddermeyer, Theresa Guenther, Marlin M Mueller, Marie-Luise Romberg, Nica Classen, Marc T Hennies, Eike R Hrincius, Stephan Ludwig, Joachim E Kuehn, Eva U Lorentzen

Journal: Vaccines (Basel)

PubMed ID: 38140236

Doi: 10.3390/vaccines11121832

Products & Services: Plasmid DNA Preparation

Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis

Authors: Xiaojian Shi, Marisa DeCiucis, Kariona A Grabinska, Jean Kanyo, Adam Liu, Tukiet T Lam, Hongying Shen

Journal: Mol Cell

PubMed ID: 38157846

Doi: 10.1016/j.molcel.2023.12.008

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tRF-1:30-Gly-CCC-3 inhibits thyroid cancer via binding to PC and modulating metabolic reprogramming

Authors: Bifei Fu, YuMing Lou, Xiaofeng Lu, Zhaolin Wu, Junjie Ni, Cong Jin, Pu Wu, Chaoyang Xu

Journal: Life Sci Alliance

PubMed ID: 38081642

Doi: 10.26508/lsa.202302285

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Humoral and cellular immunogenicity and efficacy of a coxsackievirus A10 vaccine in mice

Authors: Huan-Huan An, Meng Li, Rui-Lun Liu, Jie Wu, Sheng-Li Meng, Jing Guo, Ze-Jun Wang, Sha-Sha Qian, Shuo Shen

Journal: Emerg Microbes Infect

PubMed ID: 36373411

Doi: 10.1080/22221751.2022.2147022

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Tumor-Reactive CD8+ T Cells Enter a TCF1+PD-1- Dysfunctional State

Authors: Jessica J Roetman, Megan M Erwin, Michael W Rudloff, Natalie R Favret, Carlos R Detrés Román, Minna K I Apostolova, Kristen A Murray, Ting-Fang Lee, Youngmin A Lee, Mary Philip

Journal: Cancer Immunol Res

PubMed ID: 37844197

Doi: 10.1158/2326-6066.CIR-22-0939

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Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule

Authors: Yi-Wen Wu, Wei-Chun HuangFu, Tony Eight Lin, Chao-Hsiang Peng, Huang-Ju Tu, Ting-Yi Sung, Tzu-Ying Sung, Shih-Chung Yen, Shiow-Lin Pan, Kai-Cheng Hsu

Journal: Int J Biol Macromol

PubMed ID: 38163507

Doi: 10.1016/j.ijbiomac.2023.129074

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Injectable CNPs/DMP1-loaded self-assembly hydrogel regulating inflammation of dental pulp stem cells for dentin regeneration

Authors: Yue Zhao, Lutong Song, Mengchen Li, Haoran Peng, Xinyi Qiu, Yuyang Li, Bijun Zhu, Chao Liu, Shuangshuang Ren, Leiying Miao

Journal: Mater Today Bio

PubMed ID: 38170028

Doi: 10.1016/j.mtbio.2023.100907

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Interaction between membrane curvature sensitive factors SpoVM and SpoIVA in Bicelle condition

Authors: Jiali Chen, Yifan Wang, Shuru Lin, Quanxiang Yu, Zhengfei Qi, Wenqi Jiang, Qiang Zhao, Qingshan Bill Fu

Journal: Biochem Biophys Res Commun

PubMed ID: 38141557

Doi: 10.1016/j.bbrc.2023.149395

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Molecular characterization and functional analysis of peroxiredoxin 1 (Prx1) from roughskin sculpin (Trachidermus fasciatus)

Authors: Yingying Liu, Haiyan Cong, Caihong Bi, Haidong Zha, Shanshan Yu, Lihua Zhao, Qian Zhu

Journal: Fish Physiol Biochem

PubMed ID: 38103084

Doi: 10.1007/s10695-023-01281-7

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Systemic treatment with ubiquitin carboxy terminal hydrolase L1 TAT protein ameliorates axonal injury and reduces functional deficits after traumatic brain injury in mice

Authors: Zhiping Mi, Jie Ma, Dennis J Zeh, Marie E Rose, Jeremy J Henchir, Hao Liu, Xiecheng Ma, Guodong Cao, C Edward Dixon, Steven H Graham

Journal: Exp Neurol

PubMed ID: 38092186

Doi: 10.1016/j.expneurol.2023.114650

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Design and Engineering of Light-Induced Base Editors Facilitating Genome Editing with Enhanced Fidelity

Authors: Yangning Sun, Qi Chen, Yanbing Cheng, Xi Wang, Zixin Deng, Fuling Zhou, Yuhui Sun

Journal: Adv Sci (Weinh)

PubMed ID: 38039441

Doi: 10.1002/advs.202305311

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Use of recombinant malate dehydrogenase (MDH) and superoxide dismutase (SOD) [CuZn] as antigens in indirect ELISA for diagnosis of bovine brucellosis

Authors: Rafaella Silva Andrade, Angélica Rosa Faria, Hélida Monteiro Andrade, Júlio Sílvio de Sousa Bueno Filho, Herman Sander Mansur, Alexandra Ancelmo Piscitelli Mansur, Andrey Pereira Lage, Elaine Maria Seles Dorneles

Journal: J Microbiol Methods

PubMed ID: 38101579

Doi: 10.1016/j.mimet.2023.106874

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Covalent PROTAC design method based on a sulfonyl pyridone probe

Authors: Qinhong Luo , Yaqi Wang , Zhanfeng Hou , Huiting Liang , Licheng Tu , Yun Xing , Chuan Wan , Jianbo Liu , Rui Wang , Lizhi Zhu , Wei Han , Jianlong Wu , Fei Lu , Feng Yin , Zigang Li

Journal: Chem Commun (Camb) .

PubMed ID: 38054347

Doi: 10.1039/d3cc05127g

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