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Identification of paeoniflorin from Paeonia lactiflora pall As an inhibitor of tryptophan 2,3-dioxygenase and assessment of its pharmacological effects on depressive mice

Authors: Xiaoxia Liang, Ting Su, Pingzhou Wu, Yanting Dai, Yanmin Chen, QiQi Wang, Cheng Cao, Fenglian Chen, Qing Wang, Shuling Wang

Journal: J Ethnopharmacol

PubMed ID: 37315645

Doi: 10.1016/j.jep.2023.116714

Products & Services: Proteins, Expression, Isolation and Analysis

Antibody aggregation can lead to reduced Protein A binding capacity and low step yield

Authors: Gaoya Yuan, Meng Qu, Qi Geng, Wanyuan Dong, Xudong Zhang, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 37271409

Doi: 10.1016/j.pep.2023.106315

Products & Services: Proteins, Expression, Isolation and Analysis

Targeted deprivation of methionine with engineered Salmonella leads to oncolysis and suppression of metastasis in broad types of animal tumor models

Authors: Sujin Zhou, Yan Lin, Zhenggang Zhao, Yunhao Lai, Mengmeng Lu, Zishen Shao, Xinyu Mo, Yunping Mu, Zhipeng Liang, Xinxing Wang, Jingming Qu, Hua Shen, Fanghong Li, Allan Z Zhao

Journal: Cell Rep Med

PubMed ID: 37269826

Doi: 10.1016/j.xcrm.2023.101070

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Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing

Authors: Hyatt Balke-Want, Vimal Keerthi, Nikolaos Gkitsas, Andrew G Mancini, Gavin L Kurgan, Carley Fowler, Peng Xu, Xikun Liu, Kyle Asano, Sunny Patel, Christopher J Fisher, Annie K Brown, Ramya H Tunuguntla, Shabnum Patel, Elena Sotillo, Crystal L Mackall, Steven A Feldman

Journal: Mol Cancer

PubMed ID: 37365642

Doi: 10.1186/s12943-023-01799-7

Products & Services: Proteins, Expression, Isolation and Analysis

Genome-wide characterization of extrachromosomal circular DNA in gastric cancer and its potential role in carcinogenesis and cancer progression

Authors: Xianming Jiang, Xiaoguang Pan, Wenchao Li, Peng Han, Jiaying Yu, Jing Li, Haoran Zhang, Wei Lv, Ying Zhang, Yulong He, Xi Xiang

Journal: Cell Mol Life Sci

PubMed ID: 37369919

Doi: 10.1007/s00018-023-04838-0

Products & Services: Proteins, Expression, Isolation and Analysis

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway

Authors: Songnan Wang, Volker Böhnert, Alby J Joseph, Valentino Sudaryo, Jason Swinderman, Feiqiao B Yu, Xuchao Lyu, Gemini Skariah, Vishvak Subramanyam, Luke A Gilbert, Hani Goodarzi, Li Lingyin

Journal: biorxiv

PubMed ID: 37333273

Doi: 10.1101/2023.06.01.543353

Products & Services: Proteins, Expression, Isolation and Analysis

CLDN182 and 4-1BB bispecific antibody givastomig exerts antitumor activity through CLDN182-expressing tumor-directed T-cell activation

Authors: Jing Gao, Zhengyi Wang, Wenqing Jiang, Yanni Zhang, Zhen Meng, Yanling Niu, Zhen Sheng, Chan Chen, Xuejun Liu, Xi Chen, Chanjuan Liu, Keren Jia, Cheng Zhang, Haiyan Liao, Jaeho Jung, Eunsil Sung, Hyejin Chung, Jingwu Z Zhang, Andrew X Zhu, Lin Shen

Journal: J Immunother Cancer

PubMed ID: 37364935

Doi: 10.1136/jitc-2023-006704

Products & Services: Proteins, Expression, Isolation and Analysis

Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study

Authors: Jiayou Zhang, Xuanxuan Nian, Bo Liu, Zhegang Zhang, Wei Zhao, Xixin Han, Yumei Ma, Dongwu Jin, Hua Ma, Qingmei Zhang, Ran Qiu, Fang Li, Zheng Gong, Xuedan Li, Ying Yang, Yichao Tian, Li Zhou, Kai Duan, Xinguo Li, Zhongren Ma, Xiaoming Yang

Journal: Antiviral Res

PubMed ID: 37270159

Doi: 10.1016/j.antiviral.2023.105639

Products & Services: Molecular Biology Reagents

Intact mass analysis reveals the novel O-linked glycosylation on the stalk region of PD-1 protein

Authors: Phanthakarn Tit-Oon, Arisa Wonglangka, Klaichan Boonkanta, Mathuros Ruchirawat, Mayuree Fuangthong, Ram Sasisekharan, Amnart Khongmanee

Journal: Sci Rep

PubMed ID: 37316505

Doi: 10.1038/s41598-023-36203-3

Products & Services: Molecular Biology Reagents

Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding

Authors: Erik B Faber, Luxin Sun, Jian Tang, Emily Roberts, Sornakala Ganeshkumar, Nan Wang, Damien Rasmussen, Abir Majumdar, Laura E Hirsch, Kristen John, An Yang, Hira Khalid, Jon E Hawkinson, Nicholas M Levinson, Vargheese Chennathukuzhi, Daniel A Harki, Ernst Schönbrunn, Gunda I Georg

Journal: Nat Commun

PubMed ID: 37270540

Doi: 10.1038/s41467-023-38732-x

Products & Services: Molecular Biology Reagents

Grafting Rhodobacter sphaeroides with red algae Rubisco to accelerate catalysis and plant growth

Authors: Yu Zhou, Laura H Gunn, Rosemary Birch, Inger Andersson, Spencer M Whitney

Journal: Nat Plants

PubMed ID: 37291398

Doi: 10.1038/s41477-023-01436-7

Products & Services: Molecular Biology Reagents

Glutamine synthetase (GS) knockout (KO) using CRISPR/Cpf1 diversely enhances selection efficiency of CHO cells expressing therapeutic antibodies

Authors: Witsanu Srila, Martina Baumann, Markus Riedl, Kuntalee Rangnoi, Nicole Borth, Montarop Yamabhai

Journal: Sci Rep

PubMed ID: 37380701

Doi: 10.1038/s41598-023-37288-6

Products & Services: Proteins, Expression, Isolation and Analysis

An Inferred Ancestral CotA Laccase with Improved Expression and Kinetic Efficiency

Authors: Lei Lei, Lijun Zhao, Yiqia Hou, Chen Yue, Pulin Liu, Yanli Zheng, Wenfang Peng, Jiangke Yang

Journal: Int J Mol Sci

PubMed ID: 37446078

Doi: 10.3390/ijms241310901

Products & Services: Recombinant Proteins

Increasing sensitivity of antibody-antigen interactions using photo-cross-linking

Authors: Alba Torrents de la Peña, Leigh M Sewall, Rebeca de Paiva Froes Rocha, Abigail M Jackson, Payal P Pratap, Sandhya Bangaru, Christopher A Cottrell, Subhasis Mohanty, Albert C Shaw, Andrew B Ward

Journal: Cell Rep Methods

PubMed ID: 37426749

Doi: 10.1016/j.crmeth.2023.100509

Products & Services: Proteins, Expression, Isolation and Analysis

Author Correction: RNA conformational propensities determine cellular activity

Authors: Megan L Ken, Rohit Roy, Ainan Geng, Laura R Ganser, Akanksha Manghrani, Bryan R Cullen, Ursula Schulze-Gahmen, Daniel Herschlag, Hashim M Al-Hashimi

Journal: Nature

PubMed ID: 37296211

Doi: 10.1038/s41586-023-06286-z

Products & Services: Peptide Synthesis

Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation

Authors: Francisco X Galdos, Carissa Lee, Soah Lee, Sharon Paige, William Goodyer, Sidra Xu, Tahmina Samad, Gabriela V Escobar, Adrija Darsha, Aimee Beck, Rasmus O Bak, Matthew H Porteus, Sean M Wu

Journal: Elife

PubMed ID: 37284748

Doi: 10.7554/eLife.80075

Products & Services: Molecular Biology Reagents

Mycobacterium abscessus VapC5 toxin potentiates evasion of antibiotic killing by ribosome overproduction and activation of multiple resistance pathways

Authors: Eduardo A Troian, Heather M Maldonado, Unnati Chauhan, Valdir C Barth, Nancy A Woychik

Journal: Nat Commun

PubMed ID: 37349306

Doi: 10.1038/s41467-023-38844-4

Products & Services: Combinatorial DNA Libraries

The role of mechano-regulated YAP/TAZ in erectile dysfunction

Authors: Mintao Ji, Dongsheng Chen, Yinyin Shu, Shuai Dong, Zhisen Zhang, Haimeng Zheng, Xiaoni Jin, Lijun Zheng, Yang Liu, Yifei Zheng, Wensheng Zhang, Shiyou Wang, Guangming Zhou, Bingyan Li, Baohua Ji, Yong Yang, Yongde Xu, Lei Chang

Journal: Nat Commun

PubMed ID: 37353497

Doi: 10.1038/s41467-023-39009-z

Products & Services: Proteins, Expression, Isolation and Analysis

Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals

Authors: Ye Zhao, Huiling Wang, Tianhua He, Bo Ma, Guoguang Chen, Chimeng Tzeng

Journal: J Cell Commun Signal

PubMed ID: 37338798

Doi: 10.1007/s12079-023-00775-6

Products & Services: Gene Synthesis

Identification and Characterization of an HtrA Sheddase Produced by Coxiella burnetii

Authors: Ikram Omar Osman , Aurelia Caputo , Lucile Pinault , Jean-Louis Mege , Anthony Levasseur , Christian A Devaux

Journal: Int J Mol Sci .

PubMed ID: 37446087

Doi: 10.3390/ijms241310904

Products & Services: Gene Synthesis

Spatiotemporal and global profiling of DNA–protein interactions enables discovery of low-affinity transcription factors

Authors: An-Di Guo , Ke-Nian Yan, Hao Hu , Linhui Zhai , Teng-Fei Hu , Haixia Su , Yijia Chi , Jinyin Zha , Yechun Xu , Dongxin Zhao , Xiaojie Lu , Yong-Jiang Xu , Jian Zhang , Minjia Tan, Xiao-Hua Chen

Journal: Nat Chem .

PubMed ID: 37106095

Doi: 10.1038/s41557-023-01196-z

Products & Services: Peptide Synthesis

Preferential rabbit antibody responses to C-termini of NOTCH3 peptide immunogens

Authors: Soo Jung Lee , Mitchell B Gasche , Connor J Burrows , Akhil Kondepudi , Xiaojie Zhang, Michael M Wang

Journal: Sci Rep .

PubMed ID: 37280231

Doi: 10.1038/s41598-023-36067-7

Products & Services: Proteins, Expression, Isolation and Analysis

Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane

Authors: Wei Shi, Yongfei Cai, Haisun Zhu, Hanqin Peng, Jewel Voyer, Sophia Rits-Volloch, Hong Cao, Megan L Mayer, Kangkang Song, Chen Xu, Jianming Lu, Jun Zhang, Bing Chen

Journal: Nature

PubMed ID: 37285872

Doi: 10.1038/s41586-023-06273-4

Products & Services: Proteins, Expression, Isolation and Analysis

Bac to Bac System Efficiency for Preparing HPV Type 16 Virus-Like Particle Vaccine

Authors: H Razavi-Nikoo, E Behboudi, B Aghcheli, S M A Hashemi, A Moradi

Journal: Arch Razi Inst

PubMed ID: 38028838

Doi: 10.22092/ARI.2023.361975.2708

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery, characterization, and redesign of potent antimicrobial thanatin orthologs from and targeting LptA

Authors: Kelly Huynh, Amanuel Kibrom, Bruce R Donald, Pei Zhou

Journal: J Struct Biol X

PubMed ID: 37416832

Doi: 10.1016/j.yjsbx.2023.100091

Products & Services: Peptide Synthesis

Development and qualification of cell-based relative potency assay for a human respiratory syncytial virus (RSV) mRNA vaccine

Authors: Hualin Helen Li, Jenny Xu, Li He, Lynne Ireland Denny, Richard R Rustandi, Geethanjali Dornadula, Brock Fiorito, Zhi-Qiang Zhang

Journal: J Pharm Biomed Anal

PubMed ID: 37336039

Doi: 10.1016/j.jpba.2023.115523

Products & Services: Proteins, Expression, Isolation and Analysis

Protein-protein interactions between tenascin-R and RPTPζ/phosphacan are critical to maintain the architecture of perineuronal nets

Authors: Ashis Sinha, Jessica Kawakami, Kimberly S Cole, Aliona Ladutska, Mary Y Nguyen, Mary S Zalmai, Brandon L Holder, Victor M Broerman, Russell T Matthews, Samuel Bouyain

Journal: J Biol Chem

PubMed ID: 37356715

Doi: 10.1016/j.jbc.2023.104952

Products & Services: Proteins, Expression, Isolation and Analysis

Compound from Magnolia officinalis Ameliorates White Matter Injury by Promoting Oligodendrocyte Maturation in Chronic Cerebral Ischemia Models

Authors: Zhi Zhang, Xin Shu, Qian Cao, Lushan Xu, Zibu Wang, Chenggang Li, Shengnan Xia, Pengfei Shao, Xinyu Bao, Liang Sun, Yuhao Xu, Yun Xu

Journal: Neurosci Bull

PubMed ID: 37291477

Doi: 10.1007/s12264-023-01068-z

Products & Services: Proteins, Expression, Isolation and Analysis

Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene

Authors: Lindsey M Vansandt, Marie-Charlotte Meinsohn, Philippe Godin, Nicholas Nagykery, Natalie Sicher, Motohiro Kano, Aki Kashiwagi, Maeva Chauvin, Hatice D Saatcioglu, Julie L Barnes, Amy G Miller, Amy K Thompson, Helen L Bateman, Elizabeth M Donelan, Raquel González, Jackie Newsom, Guangping Gao, Patricia K Donahoe, Dan Wang, William F Swanson, David Pépin

Journal: Nat Commun

PubMed ID: 37280258

Doi: 10.1038/s41467-023-38721-0

Products & Services: Codon Optimization

Novel SPEA Superantigen Peptide Agonists and Peptide Agonist-TGFαL3 Conjugate In Vitro Study of Their Growth-Inhibitory Effects for Targeted Cancer Immunotherapy

Authors: Sara S Bashraheel, Sayed K Goda

Journal: Int J Mol Sci

PubMed ID: 37445686

Doi: 10.3390/ijms241310507

Products & Services: Peptide Synthesis

Expression and purification of the mitochondrial transmembrane protein FAM210A in Escherichia coli

Authors: Jared Hollinger, Jiangbin Wu, Kamel M Awayda, Mitchell R O'Connell, Peng Yao

Journal: Protein Expr Purif

PubMed ID: 37329934

Doi: 10.1016/j.pep.2023.106322

Products & Services: Proteins, Expression, Isolation and Analysis

Optimization of genetic code expansion in the baculovirus expression vector system (BEVS)

Authors:

Journal: Protein Expr Purif

PubMed ID: 37269916

Doi: 10.1016/j.pep.2023.106314

Products & Services: Proteins, Expression, Isolation and Analysis

Boophilin D1, a Kunitz type protease inhibitor, as a source of inhibitors for the ZIKA virus NS2B-NS3 protease

Authors: Veronica de Moraes Manzato, Camila Di Santo, Ricardo Jose Soares Torquato, Camila Coelho, Gloria Gallo, Leon Hardy, Martin Würtele, Aparecida Sadae Tanaka

Journal: Biochimie

PubMed ID: 37364769

Doi: 10.1016/j.biochi.2023.06.010

Products & Services: Molecular Biology Reagents

Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules

Authors: Yanglei Huang, Ziling Ye, Xiukun Wan, Ge Yao, Jingyu Duan, Jiajia Liu, Mingdong Yao, Xiang Sun, Zixin Deng, Kun Shen, Hui Jiang, Tiangang Liu

Journal: Adv Sci (Weinh)

PubMed ID: 37271925

Doi: 10.1002/advs.202300889

Products & Services: Molecular Biology Reagents

Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3

Authors: Hayarpi Torosyan, Michael D Paul, Antoine Forget, Megan Lo, Devan Diwanji, Krzysztof Pawłowski, Nevan J Krogan, Natalia Jura, Kliment A Verba

Journal: Nat Commun

PubMed ID: 37336883

Doi: 10.1038/s41467-023-38864-0

Products & Services: Gene Synthesis

Stability and structure-activity relationship of the SPA4 peptide under ambient and stressed conditions of lung injury

Authors: Asif Alam Chowdhury, Karla Rodgers, Nachiket M Godbole, Shanjana Awasthi

Journal: RSC Adv

PubMed ID: 37350860

Doi: 10.1039/d3ra02918b

Products & Services: Molecular Biology Reagents

Assimilatory sulfate reduction in the marine methanogen Methanothermococcus thermolithotrophicus

Authors: Marion Jespersen, Tristan Wagner

Journal: Nat Microbiol

PubMed ID: 37277534

Doi: 10.1038/s41564-023-01398-8

Products & Services: DNA Sequencing

Odorant-binding protein 19 in Monochamus alternatus involved in the recognition of a volatile strongly emitted from ovipositing host pines

Authors: Ruinan Yang, Dongzhen Li, Shancheng Yi, Yi Wei, Manqun Wang

Journal: Insect Sci

PubMed ID: 37358042

Doi: 10.1111/1744-7917.13238

Products & Services: Catalog Antibody

The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins

Authors: Julie Lavie, Claude Lalou, Walid Mahfouf, Jean-William Dupuy, Aurélie Lacaule, Agata Ars Cywinska, Didier Lacombe, Anne-Marie Duchêne, Anne-Aurélie Raymond, Hamid Reza Rezvani, Richard Patryk Ngondo, Giovanni Bénard

Journal: Cell Rep

PubMed ID: 37267103

Doi: 10.1016/j.celrep.2023.112579

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Modularity and diversity of target selectors in Tn7 transposons

Authors: Guilhem Faure, Makoto Saito, Sean Benler, Iris Peng, Yuri I Wolf, Jonathan Strecker, Han Altae-Tran, Edwin Neumann, David Li, Kira S Makarova, Rhiannon K Macrae, Eugene V Koonin, Feng Zhang

Journal: Mol Cell

PubMed ID: 37267947

Doi: 10.1016/j.molcel.2023.05.013

Products & Services: Molecular Biology Reagents

Performance of commercial SARS-CoV-2 wild-type and Omicron BA1 antibody assays compared with pseudovirus neutralization tests

Authors: E Habermann, L M Frommert, K Ghannam, L Nguyen My, L Gieselmann, P Tober-Lau, J Klotsche, A N Arumahandi de Silva, A Ten Hagen, J Zernicke, F Kurth, L E Sander, F Klein, G R Burmester, R Biesen, F N Albach

Journal: J Clin Virol

PubMed ID: 37354690

Doi: 10.1016/j.jcv.2023.105518

Products & Services: Proteins, Expression, Isolation and Analysis

Negatively charged, intrinsically disordered regions can accelerate target search by DNA-binding proteins

Authors: Xi Wang, Lavi S Bigman, Harry M Greenblatt, Binhan Yu, Yaakov Levy, Junji Iwahara

Journal: Nucleic Acids Res

PubMed ID: 36774964

Doi: 10.1093/nar/gkad045

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Circ_PIAS1 Promotes the Apoptosis of ALV-J Infected DF1 Cells by Up-Regulating miR-183

Authors: Ting Yang , Lingling Qiu , Shihao Chen , Zhixiu Wang , Yong Jiang , Hao Bai , Yulin Bi , Guohong Chen , Guobin Chang

Journal: Genes (Basel) .

PubMed ID: 37372440

Doi: 10.3390/genes14061260

Products & Services: Proteins, Expression, Isolation and Analysis

Broad Sarbecovirus Neutralizing Antibodies Obtained by Computational Design and Synthetic Library Screening

Authors: Xuehua Yang, Huarui Duan, Xiuying Liu, Xinhui Zhang, Shengnan Pan, Fangyuan Zhang, Peixiang Gao, Bo Liu, Jian Yang, Xiaojing Chi, Wei Yang

Journal: J Virol

PubMed ID: 37367229

Doi: 10.1128/jvi.00610-23

Products & Services: Proteins, Expression, Isolation and Analysis

Restriction of SARS-CoV-2 replication by receptor transporter protein 4 (RTP4)

Authors: Ramanjit Kaur, Takuya Tada, Nathaniel Roy Landau

Journal: MBio

PubMed ID: 37382452

Doi: 10.1128/mbio.01090-23

Products & Services: Molecular Biology Reagents

Inhibition of chitin deacetylases to attenuate plant fungal diseases

Authors: Lin Liu, Yeqiang Xia, Yingchen Li, Yong Zhou, Xiaofeng Su, Xiaojing Yan, Yan Wang, Wende Liu, Hongmei Cheng, Yuanchao Wang, Qing Yang

Journal: Nat Commun

PubMed ID: 37385996

Doi: 10.1038/s41467-023-39562-7

Products & Services: Gene Synthesis

Structural basis for the binding of DNP and purine nucleotides onto UCP1

Authors: Yunlu Kang, Lei Chen

Journal: Nature

PubMed ID: 37336486

Doi: 10.1038/s41586-023-06332-w

Products & Services: Gene Synthesis

Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

Authors: Anil Kumar Vijjamarri, Xiao Niu, Matthew D Vandermeulen, Chisom Onu, Fan Zhang, Hongfang Qiu, Neha Gupta, Swati Gaikwad, Miriam L Greenberg, Paul J Cullen, Zhenguo Lin, Alan G Hinnebusch

Journal: Elife

PubMed ID: 37266577

Doi: 10.7554/eLife.85545

Products & Services: PCR Cloning and Subcloning

Complementary methods for monitoring hole-hole homodimer associated with a WuXiBody-based asymmetric bispecific antibody

Authors: Wanyuan Dong, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 37271410

Doi: 10.1016/j.pep.2023.106316

Products & Services: Proteins, Expression, Isolation and Analysis

Chimeric antigen receptor T cells targeting FcRH5 provide robust tumour-specific responses in murine xenograft models of multiple myeloma

Authors: Dongpeng Jiang, Haiwen Huang, Huimin Qin, Koukou Tang, Xiangru Shi, Tingting Zhu, Yuqing Gao, Ying Zhang, Xiaopeng Tian, Jianhong Fu, Weiwei Qu, Weilan Cai, Yang Xu, Depei Wu, Jianhong Chu

Journal: Nat Commun

PubMed ID: 37339964

Doi: 10.1038/s41467-023-39395-4

Products & Services: Recombinant Proteins

KRT10 plays an important role in the release of viral genome from endosomes during H9N2 subtype AIV replication in HeLa cells

Authors: Xiangyu Huang, Guihu Yin, Bin Zhou, Yiqin Cai, Jianing Hu, Jingwen Huang, Zili Chen, Qingtao Liu, Xiuli Feng

Journal: Vet Microbiol

PubMed ID: 37406407

Doi: 10.1016/j.vetmic.2023.109824

Products & Services: Proteins, Expression, Isolation and Analysis

Cytoplasmic aggregation of mutant FUS causes multistep RNA splicing perturbations in the course of motor neuron pathology

Authors: Alexander P Rezvykh, Aleksey A Ustyugov, Kirill D Chaprov, Ekaterina V Teterina, Vladimir O Nebogatikov, Daria S Spasskaya, Michael B Evgen'ev, Alexey V Morozov, Sergei Yu Funikov

Journal: Nucleic Acids Res

PubMed ID: 37115004

Doi: 10.1093/nar/gkad319

Products & Services: Proteins, Expression, Isolation and Analysis

Schisandra extract ameliorates arthritis pathogenesis by suppressing the NF-κB and MAPK signalling pathways

Authors: Seong Jae Han, Hyemi Lee, Jiho Nam, Cheol-Ho Pan, Jimin Jeon, Siyoung Yang

Journal: J Cell Mol Med

PubMed ID: 37337779

Doi: 10.1111/jcmm.17814

Products & Services: Proteins, Expression, Isolation and Analysis

Effects of the deletion and substitution of thioesterase on bacillomycin D synthesis

Authors: Ping Zhang, Ziyan Lv, Zhaoxin Lu, Wenjie Ma, Xiaomei Bie

Journal: Biotechnol Lett

PubMed ID: 37266877

Doi: 10.1007/s10529-023-03373-z

Products & Services: Proteins, Expression, Isolation and Analysis

The putative role of the epipeptide EpeX in intra-species competition

Authors: Margarita Kalamara, James Abbott, Tetyana Sukhodub, Cait MacPhee, Nicola R Stanley-Wall

Journal: Microbiology (Reading)

PubMed ID: 37289492

Doi: 10.1099/mic.0.001344

Products & Services: Proteins, Expression, Isolation and Analysis

Acentrosomal spindles assemble from branching microtubule nucleation near chromosomes in Xenopus laevis egg extract

Authors: Bernardo Gouveia, Sagar U Setru, Matthew R King, Aaron Hamlin, Howard A Stone, Joshua W Shaevitz, Sabine Petry

Journal: Nat Commun

PubMed ID: 37344488

Doi: 10.1038/s41467-023-39041-z

Products & Services: Proteins, Expression, Isolation and Analysis

Epigenetic Iinsights into the Senescence of Porcine Fetal Fibroblasts induced by Passaging

Authors: Jiaying Bi, Dayu Wang, Fuquan Zhu, Xinyue Lu, Yan Xie, Huijun Liu, Meixia Wang, Xu He, Yuan Jiang, Ke Liu, Mingyue Zhao, Tingzhang Wang, Juan Li

Journal: Cell Cycle

PubMed ID: 37338871

Doi: 10.1080/15384101.2023.2222521

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Engineering BioBricks for Deoxysugar Biosynthesis and Generation of New Tetracenomycins

Authors: Heli Tirkkonen, Katelyn V. Brown, Magdalena Niemczura, Zélie Faudemer, Courtney Brown, Larissa V. Ponomareva, Yosra A. Helmy, Jon S. Thorson, S. Eric Nybo, Mikko Metsä-Ketelä, and Khaled A. Shaaban

Journal: ACS Omega

Doi: 10.1021/acsomega.3c02460

Products & Services: Gene Synthesis PCR Cloning and Subcloning

Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists

Authors: Wenjing Sun , Fan Yang , Huanhuan Zhang , Qingning Yuan , Shenglong Ling , Yuanxia Wang , Pei Lv , Zelin Li , Yifan Luo , Dongsheng Liu , Wanchao Yin , Pan Shi , H Eric Xu, Changlin Tian

Journal: Cell Discov .

PubMed ID: 37391393

Doi: 10.1038/s41421-023-00564-w

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Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation

Authors: Xiaoyun Yang , Jiaxu Wang, Simin Li , Xiaobing Li , Jingjing Gong , Zhenzhen Yan , Huan Zhou , Chen Wu , Xiuhua Liu

Journal: Nucleic Acids Res .

PubMed ID: 37334830

Doi: 10.1093/nar/gkad525

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Molecular Quantification and Mutation Detection as Essential Tools for the Clinical Management of Chronic Myeloid Leukemia Patients: Results from a Brazilian Single-Center Study

Authors: Anelis Maria Marin, Denise Kusma Wosniaki, Heloisa Bruna Soligo Sanchuki, Eduardo Cilião Munhoz, Jeanine Marie Nardin, Gabriela Silva Soares, Dhienifer Caroline Espinace, João Samuel de Holanda Farias, Bruna Veroneze, Luiz Felipe Becker, Guilherme Lima Costa, Olair Carlos Beltrame, Jaqueline Carvalho de Oliveira, Geison Cambri, Dalila Luciola Zanette, Mateus Nóbrega Aoki

Journal: Int J Mol Sci

PubMed ID: 37373266

Doi: 10.3390/ijms241210118

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Isolation of recombinant apolipoprotein E4 N-terminal domain by foam fractionation

Authors: Kyle Lethcoe, Colin A Fox, Anouar Hafiane, Robert S Kiss, Robert O Ryan

Journal: Protein Expr Purif

PubMed ID: 37290717

Doi: 10.1016/j.pep.2023.106319

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Clostridium perfringens epsilon prototoxin mutant rpETX as a vaccine candidate against enterotoxemia

Authors: Jige Du, Tuanjie Wang, Lei Xu, Cong Wang, Ying Liu, Chenfan Pan, Xiaoyun Chen, Zhen Zhu, Yufeng Luo, Chunsheng Yin

Journal: Vaccine

PubMed ID: 37357076

Doi: 10.1016/j.vaccine.2023.06.044

Products & Services: Molecular Biology Reagents

Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates

Authors: Steven Boeynaems, Yanniv Dorone, Yanrong Zhuang, Victoria Shabardina, Guozhong Huang, Anca Marian, Garam Kim, Anushka Sanyal, Nesli-Ece Şen, Daniel Griffith, Roberto Docampo, Keren Lasker, Iñaki Ruiz-Trillo, Georg Auburger, Alex S Holehouse, Edor Kabashi, Yi Lin, Aaron D Gitler

Journal: Mol Cell

PubMed ID: 37295429

Doi: 10.1016/j.molcel.2023.05.025

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MitoNEET prevents iron overload-induced insulin resistance in H9c2 cells through regulation of mitochondrial iron

Authors: Eddie Tam, Hye K Sung, Gary Sweeney

Journal: J Cell Physiol

PubMed ID: 37269467

Doi: 10.1002/jcp.31044

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Revealing the impact of CD70 expression on the manufacture and functions of CAR-70 T-cells based on single-cell transcriptomics

Authors: Jiali Cheng, Yuyan Zhao, Hui Hu, Ling Tang, Yuhao Zeng, Xinyue Deng, Shengnan Ding, An-Yuan Guo, Qing Li, Xiaojian Zhu

Journal: Cancer Immunol Immunother

PubMed ID: 37382633

Doi: 10.1007/s00262-023-03475-7

Products & Services: Proteins, Expression, Isolation and Analysis

Comparative assessment of homemade ELISA and lateral flow assay (LFA)in the rapid, specific and sensitive detection of SARS-CoV-2 anti-nucleocapsid protein in sera of Egyptian patients

Authors: Asmaa El-Shershaby, Nahla Hussein, Esraa Ali, Amr El-Hakim, Ashraf Tabll, Mohamed Shaheen, Ibrahim Ali, Mahmoud Elshall, Yasser Shahein

Journal: J Immunoassay Immunochem

PubMed ID: 37319429

Doi: 10.1080/15321819.2023.2224865

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SpyTag/SpyCatcher display of influenza M2e peptide on norovirus-like particle provides stronger immunization than direct genetic fusion

Authors: Vili Lampinen, Stina Gröhn, Saana Soppela, Vesna Blazevic, Vesa P Hytönen, Minna M Hankaniemi

Journal: Front Cell Infect Microbiol

PubMed ID: 37424789

Doi: 10.3389/fcimb.2023.1216364

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Recombinant Bacillus Calmette-Guérin Expressing SARS-CoV-2 Chimeric Protein Protects K18-hACE2 Mice against Viral Challenge

Authors: Fábio Mambelli, Fábio V Marinho, Juvana M Andrade, Ana C V S C de Araujo, Rodrigo P F Abuna, Victor M R Fabri, Bruno P O Santos, João S da Silva, Mariana T Q de Magalhães, E Jane Homan, Luciana C C Leite, Greicy B M Dias, Nicoli Heck, Daniel A G B Mendes, Daniel S Mansur, André Báfica, Sergio C Oliveira

Journal: J Immunol

PubMed ID: 37098890

Doi: 10.4049/jimmunol.2200731

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A MYB activator, DcMYB11c, regulates carrot anthocyanins accumulation in petiole but not taproot

Authors: Ao-Qi Duan, Yuan-Jie Deng, Shan-Shan Tan, Zhi-Sheng Xu, Ai-Sheng Xiong

Journal: Plant Cell Environ

PubMed ID: 37338208

Doi: 10.1111/pce.14653

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Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics

Authors: Nan Zhao, Jessica Sook Yuin Ho, Fanye Meng, Simin Zheng, Andrew P Kurland, Lu Tian, Martha Rea-Moreno, Xiangyang Song, Ji-Seon Seo, H Ümit Kaniskan, Aartjan J W Te Velthuis, Domenico Tortorella, Ya-Wen Chen, Jeffrey R Johnson, Jian Jin, Ivan Marazzi

Journal: Cell Host Microbe

PubMed ID: 37339625

Doi: 10.1016/j.chom.2023.05.030

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Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity

Authors: Xiaoshen Wang, Xuzichao Li, Guimei Yu, Lingling Zhang, Chendi Zhang, Yong Wang, Fumeng Liao, Yanan Wen, Hang Yin, Xiang Liu, Yong Wei, Zhuang Li, Zengqin Deng, Heng Zhang

Journal: Cell Res

PubMed ID: 37311833

Doi: 10.1038/s41422-023-00839-7

Plasmodium GPI-anchored micronemal antigen is essential for parasite transmission through the mosquito host

Authors: Charlie Jennison, Janna M Armstrong, Dorender A Dankwa, Nina Hertoghs, Sudhir Kumar, Biley A Abatiyow, Myo Naung, Nana K Minkah, Kristian E Swearingen, Robert Moritz, Alyssa E Barry, Stefan H I Kappe, Ashley M Vaughan

Journal: Mol Microbiol

PubMed ID: 37314965

Doi: 10.1111/mmi.15078

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SARS-CoV-2 S1 Subunit Booster Vaccination Elicits Robust Humoral Immune Responses in Aged Mice

Authors: Eun Kim, Muhammad S Khan , Alessandro Ferrari , Shaohua Huang , Josè C Sammartino, Elena Percivalle, Thomas W Kenniston, Irene Cassaniti , Fausto Baldanti, Andrea Gambotto

Journal: Microbiology Spectrum

PubMed ID: 37162333

Doi: PMC10269910

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Li-Mg-Si bioceramics provide a dynamic immuno-modulatory and repair-supportive microenvironment for peripheral nerve regeneration

Authors: Yiting Sun , Hongjian Zhang, Yu Zhang , Zheqi Liu , Dongming He , Wanlin Xu 4, Siyi Li , Chenping Zhang , Zhen Zhang

Journal: Bioact Mater.

PubMed ID: 37292230

Doi: 10.1016/j.bioactmat.2023.05.013

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Efficient expression of a cytokine combination in Saccharomyces cerevisiae for cultured meat production

Authors: Qingzi Lei, Jun Ma, Guocheng Du, Jingwen Zhou, Xin Guan

Journal: Food Research International

Doi: 10.1016/j.foodres.2023.113017

Products & Services: Proteins, Expression, Isolation and Analysis

Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe

Authors: Jinal A Patel, Camryn Zezelic, Julie Rageul, Joanne Saldanha, Arafat Khan, Hyungjin Kim

Journal: Nucleic Acids Research

PubMed ID: 37144518

Doi: 10.1093/nar/gkad363

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Characterization of the conserved features of the NSE6 subunit of the Physcomitrium patens SMC5/6 complex

Authors: Edit Lelkes , Jitka Jemelková , Marcela Holá , Barbora Štefanovie , Peter Kolesár , Radka Vágnerová , Eva Dvořák Tomaštíková , Ales Pecinka , Karel J Angelis , Jan J Paleček

Journal: Plant J .

PubMed ID: 37191775

Doi: 10.1111/tpj.16282

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13C Electron Nuclear Double Resonance Spectroscopy-Guided Molecular Dynamics Computations Reveal the Structure of the Enzyme–Substrate Complex of an Active, N-Linked Glycosylated Lipoxygenase

Authors: Ajay Sharma , Chris Whittington , Mohammed Jabed , S Gage Hill , Anastasiia Kostenko , Tao Yu , Pengfei Li , Peter E Doan , Brian M Hoffman , Adam R Offenbacher

Journal: Biochemistry .

PubMed ID: 37115010

Doi: 10.1021/acs.biochem.3c00119

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A cryo-EM structure of KTF1-bound polymerase V transcription elongation complex

Authors: Hong-Wei Zhang, Kun Huang, Zhan-Xi Gu, Xiao-Xian Wu, Jia-Wei Wang, Yu Zhang

Journal: Nat Commun .

PubMed ID: 37253723

Doi: 10.1038/s41467-023-38619-x

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Antibacterial mechanism of the novel antimicrobial peptide Jelleine-Ic and its efficacy in controlling Pseudomonas syringae pv actinidiae in kiwifruit

Authors: Mingyu Zhang, Lifang Wang, Wei Tang, Yue Xing, Pu Liu, Xiangli Dang

Journal: Pest Manag Sci

PubMed ID: 37184207

Doi: 10.1002/ps.7548

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Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction

Authors: Joka Pipercevic, Bastian Kohl, Ruta Gerasimaite, Véronique Comte-Miserez, Sarah Hostachy, Thomas Müntener, Elia Agustoni, Henning Jacob Jessen, Dorothea Fiedler, Andreas Mayer, Sebastian Hiller

Journal: Nat Commun

PubMed ID: 37156835

Doi: 10.1038/s41467-023-38315-w

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Small-Molecule-Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death

Authors: Rita A Avelar, Amy J Armstrong, Gracie Carvette, Riya Gupta, Noah Puleo, Jose A Colina, Peronne Joseph, Alexander M Sobeck, Caitlin M O'Connor, Brynne Raines, Agharnan Gandhi, Michele L Dziubinski, Daniel S Ma, Kimberly Resnick, Sareena Singh, Kristine Zanotti, Christa Nagel, Steven Waggoner, Daffyd G Thomas, Stephanie L Skala, Junran Zhang, Goutham Narla, Analisa DiFeo

Journal: Mol Cancer Ther

PubMed ID: 36788429

Doi: 10.1158/1535-7163.MCT-21-0880

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Validation of immunoassays for the Chlamydia trachomatis antigen Pgp3 using a chimeric monoclonal antibody

Authors: Brook Goodhew, Xiaoling Tang, Jason Goldstein, Joo Lee, Diana Martin, Sarah Gwyn

Journal: Sci Rep

PubMed ID: 37142607

Doi: 10.1038/s41598-023-33834-4

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In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution

Authors: Lisandro J González, Guillermo Bahr, Mariano M González, Robert A Bonomo, Alejandro J Vila

Journal: Nat Chem Biol

PubMed ID: 37188957

Doi: 10.1038/s41589-023-01319-0

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Electronegative clusters modulate folding status and RNA binding of unstructured RNA-binding proteins

Authors: Steve Zaharias, Talia Fargason, Rory Greer, Yuhua Song, Jun Zhang

Journal: Protein Sci

PubMed ID: 37060324

Doi: 10.1002/pro.4643

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Deficient Immune Response following SARS-CoV-2 Vaccination in Patients with Hepatobiliary Carcinoma: A Forgotten, Vulnerable Group of Patients

Authors: Malte B Monin, Leona I Baier, Jens G Gorny, Moritz Berger, Taotao Zhou, Robert Mahn, Farsaneh Sadeghlar, Christian Möhring, Christoph Boesecke, Kathrin van Bremen, Jürgen K Rockstroh, Christian P Strassburg, Anna-Maria Eis-Hübinger, Matthias Schmid, Maria A Gonzalez-Carmona

Journal: Liver Cancer

PubMed ID: 37901199

Doi: 10.1159/000529608

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Development of new mutant alleles and markers for and via CRISPR/Cas9-mediated mutagenesis to reduce trypsin inhibitor content and activity in soybean seeds

Authors: Zhibo Wang, Zachary Shea, Luciana Rosso, Chao Shang, Jianyong Li, Patrick Bewick, Qi Li, Bingyu Zhao, Bo Zhang

Journal: Front Plant Sci

PubMed ID: 37223818

Doi: 10.3389/fpls.2023.1111680

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Structural analysis of ING3 protein and histone H3 binding

Authors: Mariola Ferreras-Gutiérrez, Belén Chaves-Arquero, Amaia González-Magaña, Nekane Merino, Ignacio Amusategui-Mateu, Sonia Huecas, Francisco J Medrano, Francisco J Blanco

Journal: Int J Biol Macromol

PubMed ID: 37148949

Doi: 10.1016/j.ijbiomac.2023.124724

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A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells

Authors: Peter J Cook, Su Jung Yang, Gene I Uenishi, Annaiz Grimm, Samuel E West, Li-Jie Wang, Chester Jacobs, Andrea Repele, Travis Drow, Ahmad Boukhris, Noelle P Dahl, Karen Sommer, Andrew M Scharenberg, David J Rawlings

Journal: Mol Ther

PubMed ID: 37147803

Doi: 10.1016/j.ymthe.2023.04.021

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Optogenetic inhibition of Gα signalling alters and regulates circuit functionality and early circuit formation

Authors: Jayde Lockyer, Andrew Reading, Silvia Vicenzi, Caroline Delandre, Owen Marshall, Robert Gasperini, Lisa Foa, John Y Lin

Journal: biorxiv

PubMed ID: 37214843

Doi: 10.1101/2023.05.06.539674

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Leptospiral imelysin (LIC_10713) is secretory, immunogenic and binds to laminin, fibronectin, and collagen IV

Authors: Abhijit Sarma, Dhandapani Gunasekaran, Homen Phukan, Akhil Baby, Suneetha Hariharan, Arun Kumar De, Debasis Bhattacharya, Sankar Natesan, Jebasingh Tennyson, Madathiparambil Gopalakrishnan Madanan

Journal: Appl Microbiol Biotechnol

PubMed ID: 37227474

Doi: 10.1007/s00253-023-12573-6

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CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation

Authors: Min Qiu, Zhinang Yin, Honghong Wang, Lingyu Lei, Conghui Li, Yali Cui, Rong Dai, Peiyuan Yang, Ying Xiang, Qiuzi Li, Junhui Lv, Zhuang Hu, Min Chen, Hai-Bing Zhou, Pingping Fang, Ruijing Xiao, Kaiwei Liang

Journal: Sci Adv

PubMed ID: 37205756

Doi: 10.1126/sciadv.adf8698

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Analysis and comparisons of gene expression changes in patient- derived neurons from ROHHAD, CCHS, and PWS

Authors: A Kaitlyn Victor, Tayler Hedgecock, Martin Donaldson, Daniel Johnson, Casey M Rand, Debra E Weese-Mayer, Lawrence T Reiter

Journal: Front Pediatr

PubMed ID: 37234859

Doi: 10.3389/fped.2023.1090084

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Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa

Authors: Xingyun Wang, Cong Liu, Nino Rcheulishvili, Dimitri Papukashvili, Fengfei Xie, Jiao Zhao, Xing Hu, Kaiwei Yu, Nuo Yang, Xuehua Pan, Xueyan Liu, Peng George Wang, Yunjiao He

Journal: npj Vaccines

PubMed ID: 37231060

Doi: 10.1038/s41541-023-00672-4

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Sel1-like proteins and peptides are the major -derived factors stimulating oxalate transport by human intestinal epithelial cells

Authors: Donna Arvans, Changsoo Chang, Altayeb Alshaikh, Christine Tesar, Gyorgy Babnigg, Don Wolfgeher, Stephen Kron, Dionysios Antonopoulos, Mohamed Bashir, Candace Cham, Mark Musch, Eugene Chang, Andrzej Joachimiak, Hatim Hassan

Journal: Am J Physiol Cell Physiol

PubMed ID: 37125773

Doi: 10.1152/ajpcell.00466.2021

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Complete integration of carbene-transfer chemistry into biosynthesis

Authors: Jing Huang, Andrew Quest, Pablo Cruz-Morales, Kai Deng, Jose Henrique Pereira, Devon Van Cura, Ramu Kakumanu, Edward E K Baidoo, Qingyun Dan, Yan Chen, Christopher J Petzold, Trent R Northen, Paul D Adams, Douglas S Clark, Emily P Balskus, John F Hartwig, Aindrila Mukhopadhyay, Jay D Keasling

Journal: Nature

PubMed ID: 37138074

Doi: 10.1038/s41586-023-06027-2

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De Novo Computational Design of a Lipase with Hydrolysis Activity towards Middle-Chained Fatty Acid Esters

Authors: Jinsha Huang, Xiaoman Xie, Zhen Zheng, Luona Ye, Pengbo Wang, Li Xu, Ying Wu, Jinyong Yan, Min Yang, Yunjun Yan

Journal: Int J Mol Sci

PubMed ID: 37239928

Doi: 10.3390/ijms24108581

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Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis

Authors: Stephanie M Bozonet, Nicholas J Magon, Abigail J Schwartfeger, Andreas Konigstorfer, Sarah G Heath, Margreet C M Vissers, Vanessa K Morris, Christoph Göbl, James M Murphy, Guy S Salvesen, Mark B Hampton

Journal: J Biol Chem

PubMed ID: 37150321

Doi: 10.1016/j.jbc.2023.104792

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PTPMT1 protects cardiomyocytes from necroptosis induced by γ-ray irradiation through alleviating mitochondria injury

Authors: Jing Yi, Liang Yue, Yuning Zhang, Ning Tao, Han Duan, Lin Lv, Yingxia Tan, Hua Wang

Journal: Am J Physiol Cell Physiol

PubMed ID: 37154493

Doi: 10.1152/ajpcell.00466.2022

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