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Establishment and characterization of an SV40 immortalized chicken intestinal epithelial cell line

Authors: Federico Ghiselli, Martina Felici, Andrea Piva, Ester Grilli

Journal: Poult Sci

PubMed ID: 37517361

Doi: 10.1016/j.psj.2023.102864

Products & Services: Proteins, Expression, Isolation and Analysis

Siglec15 promotes the migration of thyroid carcinoma cells by enhancing the EGFR protein stability

Authors: Sijing Huang, Zhi Ji, Jinqiang Xu, Yuerong Yang, BingRui Wu, Qihang Chen, Shuting Geng, Yu Si, Jiayue Chen, Yuanyan Wei, Cong Wang, Zhilong Ai, Jianhai Jiang

Journal: Glycobiology

PubMed ID: 37129515

Doi: 10.1093/glycob/cwad037

Products & Services: Proteins, Expression, Isolation and Analysis

Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

Authors: Camille N Pierre, Lily E Adams, Kara Anasti, Derrick Goodman, Sherry Stanfield-Oakley, John M Powers, Dapeng Li, Wes Rountree, Yunfei Wang, Robert J Edwards, S Munir Alam, Guido Ferrari, Georgia D Tomaras, Barton F Haynes, Ralph S Baric, Kevin O Saunders

Journal: biorxiv

PubMed ID: 37546738

Doi: 10.1101/2023.07.25.550460

Products & Services: Molecular Biology Reagents

The ubiquitin-protein ligase MIEL1 localizes to peroxisomes to promote seedling oleosin degradation and lipid droplet mobilization

Authors: Melissa S Traver , Bonnie Bartel

Journal: Proc Natl Acad Sci U S A .

PubMed ID: 37410814

Doi: 10.1073/pnas.2304870120

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Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer

Authors: Apostolia M Tsimberidou, Kerstin Guenther, Borje S Andersson, Regina Mendrzyk, Amir Alpert, Claudia Wagner, Anna Nowak, Katrin Aslan, Arun Satelli, Fabian Richter, Sabrina Kuttruff-Coqui, Oliver Schoor, Jens Fritsche, Zoe Coughlin, Ali S Mohamed, Kerry Sieger, Becky Norris, Rita Ort, Jennifer Beck, Henry Hiep Vo, Franziska Hoffgaard, Manuel Ruh, Linus Backert, Ignacio I Wistuba, David Fuhrmann, Nuhad K Ibrahim, Van Karlyle Morris, Bryan K Kee, Daniel M Halperin, Graciela M Nogueras-Gonzalez, Partow Kebriaei, Elizabeth J Shpall, David Vining, Patrick Hwu, Harpreet Singh, Carsten Reinhardt, Cedrik M Britten, Norbert Hilf, Toni Weinschenk, Dominik Maurer, Steffen Walter

Journal: Cancer Immunol Res

PubMed ID: 37172100

Doi: 10.1158/2326-6066.CIR-22-0444

Products & Services: Proteins, Expression, Isolation and Analysis

Protein oxidation increases SAMHD1 binding ssDNA via its regulatory site

Authors: Theresa L Simermeyer, Stephanie Batalis, LeAnn C Rogers, Owen J Zalesak, Thomas Hollis

Journal: Nucleic Acids Res

PubMed ID: 37246644

Doi: 10.1093/nar/gkad447

Products & Services: Proteins, Expression, Isolation and Analysis

Author Correction: Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses

Authors: Fredrika Hellgren, Alberto Cagigi, Rodrigo Arcoverde Cerveira, Sebastian Ols, Theresa Kern, Ang Lin, Bengt Eriksson, Michael G Dodds, Edith Jasny, Kim Schwendt, Conrad Freuling, Thomas Müller, Martin Corcoran, Gunilla B Karlsson Hedestam, Benjamin Petsch, Karin Loré

Journal: Nat Commun

PubMed ID: 37429868

Doi: 10.1038/s41467-023-39754-1

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Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States

Authors: Aijing Feng, Sarah Bevins, Jeff Chandler, Thomas J DeLiberto, Ria Ghai, Kristina Lantz, Julianna Lenoch, Adam Retchless, Susan Shriner, Cynthia Y Tang, Suxiang Sue Tong, Mia Torchetti, Anna Uehara, Xiu-Feng Wan

Journal: Nat Commun

PubMed ID: 37429851

Doi: 10.1038/s41467-023-39782-x

Products & Services: Proteins, Expression, Isolation and Analysis

Prediction of cooperative homeodomain DNA binding sites from high-throughput-SELEX data

Authors: Brittany Cain, Jordan Webb, Zhenyu Yuan, David Cheung, Hee-Woong Lim, Rhett A Kovall, Matthew T Weirauch, Brian Gebelein

Journal: Nucleic Acids Res

PubMed ID: 37114997

Doi: 10.1093/nar/gkad318

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Functionally diverse front-end desaturases are widespread in the phylum Annelida

Authors: Marc Ramos-Llorens, Francisco Hontoria, Juan C Navarro, David E K Ferrier, Óscar Monroig

Journal: Biochim Biophys Acta Mol Cell Biol Lipids

PubMed ID: 37517549

Doi: 10.1016/j.bbalip.2023.159377

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Caspase-mediated LPS sensing and pyroptosis signaling in

Authors: Shouwen Chen, Shuxin Li, Hao Chen, Yuxin Gong, Dahai Yang, Yuanxing Zhang, Qin Liu

Journal: Sci Adv

PubMed ID: 37478191

Doi: 10.1126/sciadv.adh4054

Products & Services: Proteins, Expression, Isolation and Analysis

Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity

Authors: Hudie Wei , Haolan Wang , Genxin Wang , Lingzhi Qu , Longying Jiang , Shuyan Dai , Xiaojuan Chen , Ye Zhang , Zhuchu Chen , Youjun Li , Ming Guo , Yongheng Chen

Journal: Nat Commun .

PubMed ID: 37463921

Doi: 10.1038/s41467-023-40087-2

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A Novel Bispecific Antibody for EpCAM-Directed Inhibition of the CD73/Adenosine Immune Checkpoint in Ovarian Cancer

Authors: Emily Maria Ploeg, Isabel Britsch, Anne Paulien van Wijngaarden, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Douwe Freerk Samplonius, Wijnand Helfrich

Journal: Cancers (Basel)

PubMed ID: 37509310

Doi: 10.3390/cancers15143651

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Antibody binding of amyloid beta peptide epimers/isomers and ramifications for immunotherapies and drug development

Authors: Elizabeth R Readel, Arzoo Patel, Joshua I Putman, Siqi Du, Daniel W Armstrong

Journal: Sci Rep

PubMed ID: 37524807

Doi: 10.1038/s41598-023-38788-1

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PAQR9 regulates glucose homeostasis in diabetic mice and modulates insulin secretion in β cells in vitro under stress conditions

Authors: Zixuan Li, Yijun Lin, Shixuan Zhuo, Jinzhu Chen, Lingling Chen, Shuying Wang, Yan Chen

Journal: Mol Cell Endocrinol

PubMed ID: 37499998

Doi: 10.1016/j.mce.2023.112032

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A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation

Authors: Karla Wolf, Jan Kosinski, Toby J Gibson, Nicole Wesch, Volker Dötsch, Maurizio Genuardi, Emanuela Lucci Cordisco, Stefan Zeuzem, Angela Brieger, Guido Plotz

Journal: Nucleic Acids Res

PubMed ID: 37224528

Doi: 10.1093/nar/gkad418

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Increase in SARS-CoV-2 Seroprevalence in UK Domestic Felids Despite Weak Immunogenicity of Post-Omicron Variants

Authors: Grace B Tyson, Sarah Jones, Chloe Montreuil-Spencer, Nicola Logan, Sam Scott, Hagar Sasvari, Michael McDonald, Leigh Marshall, Pablo R Murcia, Brian J Willett, William Weir, Margaret J Hosie

Journal: Viruses

PubMed ID: 37632004

Doi: 10.3390/v15081661

Products & Services: Proteins, Expression, Isolation and Analysis

Systematic investigation on the multi-scale mechanisms of bitter peptide self-assembly for flavor modulation

Authors: Rong Zhang, Wei Jia

Journal: Food Chem

PubMed ID: 37541037

Doi: 10.1016/j.foodchem.2023.137063

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Systematic analysis of the impact of phosphorylation and O-GlcNAcylation on protein subcellular localization

Authors: Senhan Xu, Suttipong Suttapitugsakul, Ming Tong, Ronghu Wu

Journal: Cell Rep

PubMed ID: 37453062

Doi: 10.1016/j.celrep.2023.112796

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A Highly-Parallelized and Low-Sample-Size chip for Simultaneous Detectison of Protein and Nucleic Acid Biomarkers in Hepatocellular Carcinoma

Authors: Yingxue Li, Qi Xu, Wei Zhang, Qi Yang, Zhen Guo, Chuanyu Li, Zhiqi Zhang, Qiongzhu Dong, Haoting Sun, Changsong Zhang, Chao Li, Jia Yao, Jinze Li, Lunxiu Qin, Lianqun Zhou

Journal: Sensors and Actuators B: Chemical

Doi: 10.1016/j.snb.2023.134112

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Production of the antidepressant orcinol glucoside in Yarrowia lipolytica with yields over 6,400-fold higher than plant extraction

Authors: Bihuan Chen , Xiaonan Liu , Yina Wang , Jie Bai , Xiangyu Liu , Guisheng Xiang , Wei Liu , Xiaoxi Zhu , Jian Cheng , Lina Lu , Guanghui Zhang , Ge Zhang, Zongjie Dai, Shuhui Zi , Shengchao Yang, Huifeng Jiang

Journal: PLoS Biol .

PubMed ID: 37279234

Doi: 10.1371/journal.pbio.3002131

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Discovery of deaminase functions by structure-based protein clustering

Authors: Jiaying Huang , Qiupeng Lin , Hongyuan Fei , Zixin He , Hu Xu , Yunjia Li , Kunli Qu , Peng Han , Qiang Gao , Boshu Li , Guanwen Liu , Lixiao Zhang , Jiacheng Hu , Rui Zhang , Erwei Zuo , Yonglun Luo , Yidong Ran , Jin-Long Qiu , Kevin Tianmeng Zhao , Caixia Gao

Journal: Cell .

PubMed ID: 37379837

Doi: 10.1016/j.cell.2023.05.041

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Cell targeting and immunostimulatory properties of a novel Fcγ-receptor-independent agonistic anti-CD40 antibody in rhesus macaques

Authors: Xianglei Yan, Sebastian Ols, Rodrigo Arcoverde Cerveira, Klara Lenart, Fredrika Hellgren, Kewei Ye, Alberto Cagigi, Marcus Buggert, Falk Nimmerjahn, Jesper Falkesgaard Højen, Daniel Parera, Ulrich Pessara, Stephan Fischer, Karin Loré

Journal: Cell Mol Life Sci

PubMed ID: 37353664

Doi: 10.1007/s00018-023-04828-2

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Melatonin attenuates monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats via activation of Sirtuin-3

Authors: Xiaofei Ren, Kui Xu, Jianming Xu, Qiao Mei

Journal: J Biochem Mol Toxicol

PubMed ID: 37350538

Doi: 10.1002/jbt.23422

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Erythroid lineage chromatin accessibility maps facilitate identification and validation of NFIX as a fetal hemoglobin repressor

Authors: Mudit Chaand, Chris Fiore, Brian Johnston, Anthony D'Ippolito, Diane H Moon, John P Carulli, Jeffrey R Shearstone

Journal: Commun Biol

PubMed ID: 37316562

Doi: 10.1038/s42003-023-05025-4

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ATXN3 controls DNA replication and transcription by regulating chromatin structure

Authors: Esperanza Hernández-Carralero, Elisa Cabrera, Gara Rodríguez-Torres, Yeray Hernández-Reyes, Abhay N Singh, Cristina Santa-María, José Miguel Fernández-Justel, Roel C Janssens, Jurgen A Marteijn, Bernd O Evert, Niels Mailand, María Gómez, Kristijan Ramadan, Veronique A J Smits, Raimundo Freire

Journal: Nucleic Acids Res

PubMed ID: 36971114

Doi: 10.1093/nar/gkad212

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Detection of phosphorylation post-translational modifications along single peptides with nanopores

Authors: Ian C Nova, Justas Ritmejeris, Henry Brinkerhoff, Theo J R Koenig, Jens H Gundlach, Cees Dekker

Journal: Nat Biotechnol

PubMed ID: 37386295

Doi: 10.1038/s41587-023-01839-z

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Electrochemical biosensor strategy combining DNA entropy-driven technology to activate CRISPR-Cas13a activity and triple-stranded nucleic acids to detect SARS-CoV-2 RdRp gene

Authors: Chenyi Zhuo, Zichun Song, Jiuying Cui, Yuanxun Gong, Qianli Tang, Kai Zhang, Xinlei Song, Xianjiu Liao

Journal: Mikrochim Acta

PubMed ID: 37351704

Doi: 10.1007/s00604-023-05848-2

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Optimization of mammalian expression vector by cis-regulatory element combinations

Authors: Lu-Yu Zhou, Shuang Zhang, Li-Yun Li, Guo-Yu Yang, Lei Zeng

Journal: Mol Genet Genomics

PubMed ID: 37318628

Doi: 10.1007/s00438-023-02042-0

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Rise of the RNA machines - self-amplification in mRNA vaccine design

Authors: Jerome D G Comes, Gorben P Pijlman, Tessy A H Hick

Journal: Trends Biotechnol

PubMed ID: 37328401

Doi: 10.1016/j.tibtech.2023.05.007

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Lymphocyte infiltration and antitumoral effect promoted by cytotoxic inflammatory proteins formulated as self-assembling, protein-only nanoparticles

Authors: Carlos Martínez-Torró, Lorena Alba-Castellón, Luis Miguel Carrasco-Díaz, Naroa Serna, Laura Imedio, Alberto Gallardo, Isolda Casanova, Ugutz Unzueta, Esther Vázquez, Ramón Mangues, Antonio Villaverde

Journal: Biomed Pharmacother

PubMed ID: 37276641

Doi: 10.1016/j.biopha.2023.114976

Products & Services: Proteins, Expression, Isolation and Analysis

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides

Authors: Xueli Cao, Yu Xiao, Erin Huiting, Xujun Cao, Dong Li, Jie Ren, Linlin Guan, Yu Wang, Lingyin Li, Joseph Bondy-Denomy, Yue Feng

Journal: biorxiv

PubMed ID: 37398474

Doi: 10.1101/2023.06.01.543220

Products & Services: Proteins, Expression, Isolation and Analysis

Enzyme assembly on nanoparticle scaffolds enhances cofactor recycling and improves coupled reaction kinetics

Authors: Joyce C Breger, Ellen R Goldman, Kimihiro Susumu, Eunkeu Oh, Christopher M Green, Shelby L Hooe, Meghna Thakur, Igor L Medintz, Gregory A Ellis

Journal: Nanoscale

PubMed ID: 37272342

Doi: 10.1039/d3nr00729d

Products & Services: Proteins, Expression, Isolation and Analysis

In Vitro and In Vivo Efficacy of a Stroma-Targeted, Tumor Microenvironment Responsive Oncolytic Adenovirus in Different Preclinical Models of Cancer

Authors: Ana Alfano, Eduardo G A Cafferata, Mariela Gangemi, Alejandro Nicola Candia, Cristian M Malnero, Ismael Bermudez, Mauricio Vargas Lopez, Gregorio David Ríos, Cecilia Rotondaro, Nicasio Cuneo, David T Curiel, Osvaldo L Podhajcer, Maria Veronica Lopez

Journal: Int J Mol Sci

PubMed ID: 37373140

Doi: 10.3390/ijms24129992

Products & Services: Proteins, Expression, Isolation and Analysis

Heme catabolism mediated by heme oxygenase in uninfected interstitial cells enables efficient symbiotic nitrogen fixation in Lotus japonicus nodules

Authors: Yu Zhou, Longlong Wang, Maria Carmen Rubio, Carmen Pérez-Rontomé, Yumiao Zhou, Yongmei Qi, Tao Tian, Weiqing Zhang, Qiuling Fan, Manuel Becana, Deqiang Duanmu

Journal: New Phytol

PubMed ID: 37329247

Doi: 10.1111/nph.19074

Products & Services: Proteins, Expression, Isolation and Analysis

NeuroMabSeq: high volume acquisition, processing, and curation of hybridoma sequences and their use in generating recombinant monoclonal antibodies and scFvs for neuroscience research

Authors: Keith G Mitchell, Belvin Gong, Samuel S Hunter, Diana Burkart-Waco, Clara E Gavira-O'Neill, Kayla M Templeton, Madeline E Goethel, Malgorzata Bzymek, Leah M MacNiven, Karl D Murray, Matthew L Settles, Lutz Froenicke, James S Trimmer

Journal: biorxiv

PubMed ID: 37425915

Doi: 10.1101/2023.06.28.546392

Products & Services: Proteins, Expression, Isolation and Analysis

N-terminal intrinsic disorder is an ancestral feature of Gγ subunits that influences the balance between different Gβγ signaling axes in yeast

Authors: Xinya Su, Yui Tik Pang, Wei Li, J C Gumbart, Joshua Kelley, Matthew Torres

Journal: J Biol Chem

PubMed ID: 37354971

Doi: 10.1016/j.jbc.2023.104947

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Exploration of T cell immune responses by expression of a dominant-negative SHP1 and SHP2

Authors: Julia Taylor, Anna Bulek, Isaac Gannon, Mathew Robson, Evangelia Kokalaki, Thomas Grothier, Callum McKenzie, Mohamed El-Kholy, Maria Stavrou, Charlotte Traynor-White, Wen Chean Lim, Panagiota Panagiotou, Saket Srivastava, Vania Baldan, James Sillibourne, Mathieu Ferrari, Martin Pule, Simon Thomas

Journal: Front Immunol

PubMed ID: 37334382

Doi: 10.3389/fimmu.2023.1119350

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RNA-binding is an ancient trait of the Annexin family

Authors: Sudarshan S Patil, Vipul Panchal, Trude Røstbø, Sofya Romanyuk, Hanne Hollås, Ruth Brenk, Ann Kari Grindheim, Anni Vedeler

Journal: Front Cell Dev Biol

PubMed ID: 37397259

Doi: 10.3389/fcell.2023.1161588

Products & Services: Proteins, Expression, Isolation and Analysis

MAP2 caps tau fibrils and inhibits aggregation

Authors: Michael R Holden, Brad J Krzesinski, Hilary A Weismiller, Justin R Shady, Martin Margittai

Journal: J Biol Chem

PubMed ID: 37286038

Doi: 10.1016/j.jbc.2023.104891

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A Novel Conserved Linear Neutralizing Epitope on the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein

Authors: Rong-Hong Hua, Shu-Jian Zhang, Bei Niu, Jin-Ying Ge, Ting Lan, Zhi-Gao Bu

Journal: Microbiol Spectr

PubMed ID: 37306579

Doi: 10.1128/spectrum.01190-23

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The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT)

Authors: Cory M Nadel, Aye C Thwin, Matthew Callahan, Kanghyun Lee, Emily Connelly, Charles S Craik, Daniel R Southworth, Jason E Gestwicki

Journal: J Mol Biol

PubMed ID: 37330289

Doi: 10.1016/j.jmb.2023.168026

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Mutations F352A and Y528A in human HSP90α reduce fibronectin association and fibrillogenesis in cell-derived matrices

Authors: Abir Chakraborty, Ronald Tonui, Adrienne Lesley Edkins

Journal: Cell Stress Chaperones

PubMed ID: 37353709

Doi: 10.1007/s12192-023-01362-9

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Identification and targeting of protein tyrosine kinase 7 (PTK7) as an immunotherapy candidate for neuroblastoma

Authors: Jasmine Y Lee, Hunter C Jonus, Arhanti Sadanand, Gianna M Branella, Victor Maximov, Suttipong Suttapitugsakul, Matthew J Schniederjan, Jenny Shim, Andrew Ho, Kiran K Parwani, Andrew Fedanov, Adeiye A Pilgrim, Jordan A Silva, Robert W Schnepp, Christopher B Doering, Ronghu Wu, H Trent Spencer, Kelly C Goldsmith

Journal: Cell Rep Med

PubMed ID: 37343516

Doi: 10.1016/j.xcrm.2023.101091

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The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics

Authors: Sook Wah Yee, Christian Macdonald, Darko Mitrovic, Xujia Zhou, Megan L Koleske, Jia Yang, Dina Buitrago Silva, Patrick Rockefeller Grimes, Donovan Trinidad, Swati S More, Linda Kachuri, John S Witte, Lucie Delemotte, Kathleen M Giacomini, Willow Coyote-Maestas

Journal: biorxiv

PubMed ID: 37333090

Doi: 10.1101/2023.06.06.543963

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Efficient production of fluorophore-labeled CC chemokines for biophysical studies using recombinant enterokinase and recombinant sortase

Authors: Wenyan Guan, Ning Zhang, Arjan Bains, Mourad Sadqi, Cynthia M Dupureur, Patricia J LiWang

Journal: Biopolymers

PubMed ID: 37341434

Doi: 10.1002/bip.23557

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Nullomer peptide increases immune cell infiltration and reduces tumor metabolism in triple negative breast cancer mouse model

Authors: Nilufar Ali, Cody Wolf, Swarna Kanchan, Shivakumar R Veerabhadraiah, Laura Bond, Matthew W Turner, Cheryl L Jorcyk, Greg Hampikian

Journal: Res Sq

PubMed ID: 37461536

Doi: 10.21203/rs.3.rs-3097552/v1

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miR‑124 inhibits cardiomyocyte apoptosis in myocardial ischaemia‑reperfusion injury by activating mitochondrial calcium uniporter regulator 1

Authors: Linlin Guo, Chaoying Liu, Chunyan Jiang, Yanhan Dong, Lynn Htet Htet Aung, Han Ding, Yanyan Gao

Journal: Mol Med Rep

PubMed ID: 37326122

Doi: 10.3892/mmr.2023.13031

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Photoperiod Induces DNA Methylation Changes in the Melatonin Receptor 1A Gene in Ewes

Authors: Xiaoyun He, Wei Wang, Wei Sun, Mingxing Chu

Journal: Animals (Basel)

PubMed ID: 37370427

Doi: 10.3390/ani13121917

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Three to four mRNA COVID-19 vaccines in multiple sclerosis patients on immunosuppressive drugs: Seroconversion and variant neutralization

Authors: Céline Louapre, Lisa Belin, Stéphane Marot, Amandine Hippolyte, Edouard Januel, Michella Ibrahim, Lina Jeantin, Karen Zafilaza, Isabelle Malet, Fanny Charbonnier-Beaupel, Michelle Rosenzwajg, Cathia Soulié, Anne-Geneviève Marcelin, Valérie Pourcher

Journal: Eur J Neurol

PubMed ID: 37310391

Doi: 10.1111/ene.15925

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Direct fluorescent labeling of NF186 and NaV16 in living primary neurons using bioorthogonal click chemistry

Authors: Nevena Stajković, Yuanyuan Liu, Aleksandra Arsić, Ning Meng, Hang Lyu, Nan Zhang, Dirk Grimm, Holger Lerche, Ivana Nikić-Spiegel

Journal: J Cell Sci

PubMed ID: 37288813

Doi: 10.1242/jcs.260600

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Identification of a damage-associated molecular pattern (DAMP) receptor and its cognate peptide ligand in sweet potato (Ipomoea batatas)

Authors: Hsueh-Han Lu, Anja K Meents, Judith Fliegmann, Ming-Jing Hwang, Ching-Shu Suen, Diana Masch, Georg Felix, Axel Mithöfer, Kai-Wun Yeh

Journal: Plant Cell Environ

PubMed ID: 37267124

Doi: 10.1111/pce.14633

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Rapid and definitive treatment of phenylketonuria in variant-humanized mice with corrective editing

Authors: Dominique L Brooks, Manuel J Carrasco, Ping Qu, William H Peranteau, Rebecca C Ahrens-Nicklas, Kiran Musunuru, Mohamad-Gabriel Alameh, Xiao Wang

Journal: Nat Commun

PubMed ID: 37301931

Doi: 10.1038/s41467-023-39246-2

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Efficient enzymatic synthesis of chiral 2,3-dihydro-1,4-benzodioxane motif using engineered lipase B

Authors: Zhiyun Wu, Weifeng Shi, Ming Jin, Wei Zhou

Journal: RSC Adv

PubMed ID: 37350861

Doi: 10.1039/d3ra02623j

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Trypanosoma cruzi Tc24 Antigen Expressed and Orally Delivered by Schizochytrium sp Microalga is Immunogenic in Mice

Authors: Abel Ramos-Vega, Elizabeth Monreal-Escalante, Sergio Rosales-Mendoza, Bernardo Bañuelos-Hernández, Eric Dumonteil, Carlos Angulo

Journal: Mol Biotechnol

PubMed ID: 37344711

Doi: 10.1007/s12033-023-00763-6

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Varicella-zoster virus proteome-wide T-cell screening demonstrates low prevalence of virus-specific CD8 T-cells in latently infected human trigeminal ganglia

Authors: Michiel van Gent, Werner J D Ouwendijk, Victoria L Campbell, Kerry J Laing, Georges M G M Verjans, David M Koelle

Journal: J Neuroinflammation

PubMed ID: 37308917

Doi: 10.1186/s12974-023-02820-y

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Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis

Authors: Tian Xie , Peng Liu , Xinyue Wu , Feitong Dong, Zike Zhang, Jian Yue, Usha Mahawar, Faheem Farooq, Hisham Vohra, Qi Fang, Wenchen Liu, Binks W Wattenberg, Xin Gong

Journal: Nat Commun.

PubMed ID: 37308477

Doi: 10.1038/s41467-023-39274-y

Products & Services: Proteins, Expression, Isolation and Analysis

Persistent serum protein signatures define an inflammatory subcategory of long COVID

Authors: Aarthi Talla, Suhas V Vasaikar, Gregory Lee Szeto, Maria P Lemos, Julie L Czartoski, Hugh MacMillan, Zoe Moodie, Kristen W Cohen, Lamar B Fleming, Zachary Thomson, Lauren Okada, Lynne A Becker, Ernest M Coffey, Stephen C De Rosa, Evan W Newell, Peter J Skene, Xiaojun Li, Thomas F Bumol, M Juliana McElrath, Troy R Torgerson

Journal: Nat Commun

PubMed ID: 37296110

Doi: 10.1038/s41467-023-38682-4

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Protein O-GlcNAcylation homeostasis regulates facultative heterochromatin to fine-tune sog-Dpp signaling during Drosophila early embryogenesis

Authors: Yaowen Zhang, Haibin Yu, Dandan Wang, Xiaoyun Lei, Yang Meng, Na Zhang, Fang Chen, Lu Lv, Qian Pan, Hongtao Qin, Zhuohua Zhang, Daan M F van Aalten, Kai Yuan

Journal: J Genet Genomics

PubMed ID: 37286164

Doi: 10.1016/j.jgg.2023.05.014

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Assessment of Broadly Reactive Responses in Patients With MERS-CoV Infection and SARS-CoV-2 Vaccination

Authors: Hadeel T Zedan, Maria K Smatti, Swapna Thomas, Gheyath K Nasrallah, Nahla M Afifi, Ali Ait Hssain, Laith J Abu Raddad, Peter V Coyle, Jean-Charles Grivel, Muna A Almaslamani, Asmaa A Althani, Hadi M Yassine

Journal: JAMA Netw Open

PubMed ID: 37389876

Doi: 10.1001/jamanetworkopen.2023.19222

Products & Services: Proteins, Expression, Isolation and Analysis

Atomic model for core modifying region of human fatty acid synthase in complex with Denifanstat

Authors: S M Naimul Hasan, Jennifer W Lou, Alexander F A Keszei, David L Dai, Mohammad T Mazhab-Jafari

Journal: Nat Commun

PubMed ID: 37308485

Doi: 10.1038/s41467-023-39266-y

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PGC7 regulates H3K27me3 modification by inhibiting the interaction of YY1 with PRC2

Authors: Weijie Hao, Chenyang Huang, Defu Liu, Hongyu Xu, Yingxiang Liu, Yian Guan, Bingxue Chen, Zekun Guo

Journal: Am J Physiol Cell Physiol

PubMed ID: 37306391

Doi: 10.1152/ajpcell.00041.2023

Three neutralizing mAbs induced by MPXV A29L protein recognizing different epitopes act synergistically against orthopoxvirus

Authors: Mengjun Li, Zuning Ren, Yuelin Wang, Yushan Jiang, Minghui Yang, Delin Li, Jiayin Chen, Zuxin Liang, Yuhao Lin, Zhujun Zeng, Rui Xu, Yiting Wang, Li Zhu, Weiwei Xiao, Qinghua Wu, Bao Zhang, Chengsong Wan, Yang Yang, Bo Wu, Jie Peng, Wei Zhao, Chenguang Shen

Journal: Emerging Microbes & Infections.

PubMed ID: 37288876

Doi: 10.1080/22221751.2023.2223669

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Identification of Anti-Influenza A Compounds Inhibiting the Viral Non-Structural Protein 1 (NS1) Using a Type I Interferon-Driven Screening Strategy

Authors: Giulia Marsili, Chiara Acchioni, Anna Lisa Remoli, Donatella Amatore, Rossella Sgarbanti, Marta De Angelis, Roberto Orsatti, Marta Acchioni, Andrea Astolfi, Nunzio Iraci, Simona Puzelli, Marzia Facchini, Edvige Perrotti, Violetta Cecchetti, Stefano Sabatini, Fabiana Superti, Mariangela Agamennone, Maria Letizia Barreca, John Hiscott, Lucia Nencioni, Marco Sgarbanti

Journal: Int J Mol Sci

PubMed ID: 37445672

Doi: 10.3390/ijms241310495

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The SnRK23-AREB1-TST1/2 cascade activated by cytosolic glucose regulates sugar accumulation across tonoplasts in apple and tomato

Authors: Lingcheng Zhu, Yanzhen Li, Chengcheng Wang, Zhiqi Wang, Wenjing Cao, Jing Su, Yunjing Peng, Baiyun Li, Baiquan Ma, Fengwang Ma, Yong-Ling Ruan, Mingjun Li

Journal: Nat Plants

PubMed ID: 37291399

Doi: 10.1038/s41477-023-01443-8

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Lymphocyte transformation test in the diagnosis of adult fish-induced enterocolitis syndrome

Authors: Ana Entrala, Javier Domínguez-Ortega, Elisa Pulido Lucas, Itsaso Losantos, Magdalena Lluch-Bernal, Santiago Quirce, Rosa Rodríguez-Perez

Journal: J Allergy Clin Immunol Pract

PubMed ID: 37329953

Doi: 10.1016/j.jaip.2023.06.013

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LC-MS/MS-Based Absolute Quantitation of Hemoglobin Subunits from Dried Blood Spots Reveals Novel Biomarkers for α-Thalassemia Silent Carriers

Authors: Zhe Ren, Guoying Sun, Qianqian Zhang, Shaomin Zou, Jianhong Chen, Weining Zhao, Guixue Hou, Zeyan Zhong, Jialong Li, Yuhua Ye, Xiangmin Xu, Liang Lin

Journal: Anal Chem

PubMed ID: 37285171

Doi: 10.1021/acs.analchem.3c00895

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Hepatic transcriptome analysis provides new insights into ghrelin regulation of the liver in Nile tilapia ()

Authors: Huan Zhong, Chenyi Lou, Bingxin Ren, Jiamin Pi, Tao Dai, Weiling Qin, Yi Zhou

Journal: Front Vet Sci

PubMed ID: 37388466

Doi: 10.3389/fvets.2023.1192195

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Novel mechanisms for the removal of strong replication-blocking HMCES- and thiazolidine-DNA adducts in humans

Authors: Yohei Sugimoto, Yuji Masuda, Shigenori Iwai, Yumi Miyake, Rie Kanao, Chikahide Masutani

Journal: Nucleic Acids Res

PubMed ID: 37021581

Doi: 10.1093/nar/gkad246

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Improved extracellular vesicle-based mRNA delivery for familial hypercholesterolemia treatment

Authors: Zheng Yang, Panpan Ji, Zhelong Li, Rongxin Zhang, Mengying Wei, Yang Yang, Lijun Yuan, Yan Han, Guodong Yang

Journal: Theranostics

PubMed ID: 37351166

Doi: 10.7150/thno.82873

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Engineering Scheffersomyces segobiensis for palmitoleic acid-rich lipid production

Authors: Xiujuan Qian, Huirui Lei, Xinhai Zhou, Lili Zhang, Wenxing Cui, Jie Zhou, Fengxue Xin, Weiliang Dong, Min Jiang, Katrin Ochsenreither

Journal: Microb Biotechnol

PubMed ID: 37351580

Doi: 10.1111/1751-7915.14301

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Effect of moderate prenatal ethanol exposure on the differential expression of two histamine H3 receptor isoforms in different brain regions of adult rat offspring

Authors: Suzy Davies, Kiana S Lujan, Ella J Rappaport, Carlos F Valenzuela, Daniel D Savage

Journal: Front Neurosci

PubMed ID: 37449267

Doi: 10.3389/fnins.2023.1192096

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Multisite transformation in : insights on transformations mechanisms and new genetic modification protocols

Authors: Vui Yin Seow, Olga Tsygelnytska, Nicolas Biais

Journal: Front Microbiol

PubMed ID: 37408636

Doi: 10.3389/fmicb.2023.1178128

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MERS-CoV RBD-mRNA vaccine induces potent and broadly neutralizing antibodies with protection against MERS-CoV infection

Authors: Wanbo Tai, Jian Zheng, Xiujuan Zhang, Juan Shi, Gang Wang, Xiaoqing Guan, Jiang Zhu, Stanley Perlman, Lanying Du

Journal: Virus Res

PubMed ID: 37336390

Doi: 10.1016/j.virusres.2023.199156

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Two Recombinant Bacteriocins, Rhamnosin and Lysostaphin, Show Synergistic Anticancer Activity Against Gemcitabine-Resistant Cholangiocarcinoma Cell Lines

Authors: Kankamol Kerdkumthong, Wannarat Chanket, Phanthipha Runsaeng, Sutthipong Nanarong, Kawinnath Songsurin, Phonprapavee Tantimetta, Chanan Angsuthanasombat, Aratee Aroonkesorn, Sumalee Obchoei

Journal: Probiotics Antimicrob Proteins

PubMed ID: 37294416

Doi: 10.1007/s12602-023-10096-0

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GRT-R910: a self-amplifying mRNA SARS-CoV-2 vaccine boosts immunity for ≥6 months in previously-vaccinated older adults

Authors: Christine D Palmer, Ciaran D Scallan, Lauren D Kraemer Tardif, Melissa A Kachura, Amy R Rappaport, Daniel O Koralek, Alison Uriel, Leonid Gitlin, Joshua Klein, Matthew J Davis, Harshni Venkatraman, Meghan G Hart, Jason R Jaroslavsky, Sonia Kounlavouth, Martina Marrali, Charmaine N Nganje, Kyounghwa Bae, Tiffany Yan, Katharyn Leodones, Milana Egorova, Sue-Jean Hong, Jenchun Kuan, Silvia Grappi, Pedro Garbes, Karin Jooss, Andrew Ustianowski

Journal: Nat Commun

PubMed ID: 37280238

Doi: 10.1038/s41467-023-39053-9

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Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS

Authors: Yuta Adachi, Ryo Kimura, Kentaro Hirade, Shogo Yanase, Yuki Nishioka, Natsumi Kasuga, Rui Yamaguchi, Hiromichi Ebi

Journal: Nat Cancer

PubMed ID: 37277529

Doi: 10.1038/s43018-023-00575-2

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Structural mechanism of intracellular autoregulation of zinc uptake in ZIP transporters

Authors: Changxu Pang, Jin Chai, Ping Zhu, John Shanklin, Qun Liu

Journal: Nat Commun

PubMed ID: 37296139

Doi: 10.1038/s41467-023-39010-6

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Flavonoid quercetin and its glucuronide and sulfate conjugates bind to 67-kDa laminin receptor and prevent neuronal cell death induced by serum starvation

Authors: Rayudu Gopalakrishna, Andrew Oh, Lucas Hou, Emily Lee, Jennifer Aguilar, Andrew Li, William J Mack

Journal: Biochem Biophys Res Commun

PubMed ID: 37300941

Doi: 10.1016/j.bbrc.2023.06.007

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Neutralizing Antibodies in COVID-19 Serum from Tatarstan, Russia

Authors: Shaimaa Hamza, Ekaterina Martynova, Ekaterina Garanina, Venera Shakirova, Alisa Bilalova, Svetlana Moiseeva, Ilsiyar Khaertynova, Olesia Ohlopkova, Nataliya Blatt, Maria Markelova, Svetlana Khaiboullina

Journal: Int J Mol Sci

PubMed ID: 37373331

Doi: 10.3390/ijms241210181

Products & Services: Proteins, Expression, Isolation and Analysis

Wheat Class III Peroxidase TaPOD70 Is a Potential Susceptibility Factor Negatively Regulating Wheat Resistance to f sp

Authors: Ruobing Li, Xiaoxu Zhang, Bingjie Zhao, Panpan Song, Xiaomei Zhang, Baotong Wang, Qiang Li

Journal: Phytopathology

PubMed ID: 36812407

Doi: 10.1094/PHYTO-01-23-0001-FI

Products & Services: Proteins, Expression, Isolation and Analysis

Void Volume Fraction of Granular Scaffolds

Authors: Lindsay Riley, Grace Wei, Yijun Bao, Peter Cheng, Katrina L Wilson, Yining Liu, Yiyang Gong, Tatiana Segura

Journal: Small

PubMed ID: 37267936

Doi: 10.1002/smll.202303466

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A novel self-purified auxiliary protein enhances the lichenase activity towards lichenan for biomass degradation

Authors: Rui Zhou, Lingzhi Zhang, Bo Zeng, Yanhong Zhou, Wenhui Jin, Guangya Zhang

Journal: Appl Microbiol Biotechnol

PubMed ID: 37272940

Doi: 10.1007/s00253-023-12608-y

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Rapid and Facile Light-Based Approach to Fabricate Protease-Degradable Poly(ethylene glycol)-norbornene Microgels for Cell Encapsulation

Authors: Ana Mora-Boza, Saron G Ghebrezadik, Johannes E Leisen, Andrés J García

Journal: Adv Healthc Mater

PubMed ID: 37235850

Doi: 10.1002/adhm.202300942

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Schlafen4-MDSC in -induced gastric metaplasia reveals role for GTPases

Authors: Lin Ding, Sulaiman Sheriff, Ricky A Sontz, Juanita L Merchant

Journal: Front Immunol

PubMed ID: 37334372

Doi: 10.3389/fimmu.2023.1139391

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Functional Diversity of Homologous Oxidoreductases-Tuning of Substrate Specificity by a FAD-Stacking Residue for Iron Acquisition and Flavodoxin Reduction

Authors: Marta Hammerstad, Anne Kristine Rugtveit, Sondov Dahlen, Hilde Kristin Andersen, Hans-Petter Hersleth

Journal: Antioxidants (Basel)

PubMed ID: 37371954

Doi: 10.3390/antiox12061224

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Engineering B cells with customized therapeutic responses using a synthetic circuit

Authors: Audrey Page, Marie Delles, Didier Nègre, Caroline Costa, Floriane Fusil, François-Loïc Cosset

Journal: Mol Ther Nucleic Acids

PubMed ID: 37359346

Doi: 10.1016/j.omtn.2023.05.024

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Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

Authors: Liang Chen, Mengjia Hong, Changming Luan, Hongyi Gao, Gaomeng Ru, Xinyuan Guo, Dujuan Zhang, Shun Zhang, Changwei Li, Jun Wu, Peyton B Randolph, Alexander A Sousa, Chao Qu, Yifan Zhu, Yuting Guan, Liren Wang, Mingyao Liu, Bo Feng, Gaojie Song, David R Liu, Dali Li

Journal: Nat Biotechnol

PubMed ID: 37322276

Doi: 10.1038/s41587-023-01821-9

Folding Double-Stranded DNA into Designed Shapes with Triplex-Forming Oligonucleotides

Authors: Cindy Ng , Anirban Samanta , Ole Aalund Mandrup , Emily Tsang , Sarah Youssef , Lasse Hyldgaard Klausen , Mingdong Dong , Minke A D Nijenhuis , Kurt V Gothelf

Journal: Adv Mater .

PubMed ID: 37311656

Doi: 10.1002/adma.202302497

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A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells

Authors: Aoxing Cheng, Tian Xu , Weiyi You, Ting Wang, Dongming Zhang, Huimin Guo , Haiyan Zhang , Xin Pan , Yucai Wang , Liu Liu , Kaiguang Zhang , Jue Shi , Xuebiao Yao ， Jing Guo , Zhenye Yang

Journal: Nat Metab .

PubMed ID: 37349486

Doi: 10.1038/s42255-023-00832-9

Products & Services: Antibody Modification and Purification Services

Improving therapeutic protein secretion in the probiotic yeast Saccharomyces boulardii using a multifactorial engineering approach

Authors: Deniz Durmusoglu, Ibrahim Al'Abri, Zidan Li, Taufika Islam Williams, Leonard B Collins, José L Martínez, Nathan Crook

Journal: Microb Cell Fact

PubMed ID: 37287064

Doi: 10.1186/s12934-023-02117-y

Products & Services: Proteins, Expression, Isolation and Analysis

Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae

Authors: Mitchell A Ellison, Sanchirmaa Namjilsuren, Margaret K Shirra, Matthew S Blacksmith, Rachel A Schusteff, Eleanor M Kerr, Fei Fang, Yufei Xiang, Yi Shi, Karen M Arndt

Journal: Nucleic Acids Res

PubMed ID: 36928138

Doi: 10.1093/nar/gkad180

Products & Services: Proteins, Expression, Isolation and Analysis

Targeted sequencing of cancer-related genes reveals a recurrent TOP2A variant which affects DNA binding and coincides with global transcriptional changes in glioblastoma

Authors: Bartlomiej Gielniewski, Katarzyna Poleszak, Adria-Jaume Roura, Paulina Szadkowska, Karol Jacek, Sylwia K Krol, Rafal Guzik, Paulina Wiechecka, Marta Maleszewska, Beata Kaza, Andrzej Marchel, Tomasz Czernicki, Andrzej Koziarski, Grzegorz Zielinski, Andrzej Styk, Maciej Kawecki, Cezary Szczylik, Ryszard Czepko, Mariusz Banach, Wojciech Kaspera, Wojciech Szopa, Mateusz Bujko, Bartosz Czapski, Miroslaw Zabek, Ewa Iżycka-Świeszewska, Wojciech Kloc, Pawel Nauman, Joanna Cieslewicz, Wieslawa Grajkowska, Natalia Morosini, Houtan Noushmehr, Bartosz Wojtas, Bozena Kaminska

Journal: Int J Cancer

PubMed ID: 37338006

Doi: 10.1002/ijc.34631

Products & Services: Proteins, Expression, Isolation and Analysis

Virtual screening, identification, and potential antioxidant mechanism of novel bioactive peptides during aging by a short-chain peptidomics, quantitative structure-activity relationship analysis, and molecular docking

Authors: An Du, Wei Jia

Journal: Food Res Int

PubMed ID: 37689894

Doi: 10.1016/j.foodres.2023.113129

Products & Services: Proteins, Expression, Isolation and Analysis

Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection

Authors: Manuela C Aguirre-Botero, Lawrence T Wang, Pauline Formaglio, Eduardo Aliprandini, Jean-Michel Thiberge, Arne Schön, Yevel Flores-Garcia, Shamika Mathis-Torres, Barbara J Flynn, Lais da Silva Pereira, Yann Le Duff, Mathew Hurley, Adéla Nacer, Paul W Bowyer, Fidel Zavala, Azza H Idris, Joseph R Francica, Robert A Seder, Rogerio Amino

Journal: Cell Rep

PubMed ID: 37389992

Doi: 10.1016/j.celrep.2023.112681

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Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases

Authors: Victoria A Kleiner, Thierry O Fischmann, John A Howe, Douglas C Beshore, Michael J Eddins, Yan Hou, Todd Mayhood, Daniel Klein, Debbie D Nahas, Bob J Lucas, He Xi, Edward Murray, Daphne Y Ma, Krista Getty, Rachel Fearns

Journal: Commun Biol

PubMed ID: 37337079

Doi: 10.1038/s42003-023-04990-0

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Near atmospheric carbon dioxide activates plant ubiquitin cross-linking

Authors: Harry G Gannon, Martin J Cann

Journal: BBA Adv

PubMed ID: 37416898

Doi: 10.1016/j.bbadva.2023.100096

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A bioengineered pseudovirus nanoparticle displaying SARS-CoV 2 RBD fully protects mice from mortality and weight loss caused by SARS-CoV 2 challenge

Authors: Ming Xia, Krisangel López, Frank S Vago, Pengwei Huang, Dawn I Auguste, Wen Jiang, Albert J Auguste, Ming Tan

Journal: Biotechnol J

PubMed ID: 37300425

Doi: 10.1002/biot.202300130

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Assessing the Feasibility of Employing a Combination of a Bacteriophage-Derived Endolysin and Spore Germinants to Treat Relapsing Infection

Authors: Khalid Alyahya, Les Baillie

Journal: Microorganisms

PubMed ID: 37512824

Doi: 10.3390/microorganisms11071651

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Expression and characterization of recombinant IL-1Ra in Aspergillus oryzae as a system

Authors: Lena Mahmoudi Azar, Elif Karaman, Burcu Beyaz, Işılay Göktan, Alp Ertunga Eyüpoğlu, Seda Kizilel, Batu Erman, Ahmet Gül, Serdar Uysal

Journal: BMC Biotechnol

PubMed ID: 37340430

Doi: 10.1186/s12896-023-00785-7

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