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Stromal cell-derived factor-1 downregulation contributes to neuroprotection mediated by CXC chemokine receptor 4 interactions after intracerebral hemorrhage in rats

Authors: Yu Wu, Zhuwei Zhang, Xiaoou Sun, Jing Wang, Haitao Shen, Xue Sun, Zhong Wang

Journal: CNS Neurosci Ther

PubMed ID: 37614198

Doi: 10.1111/cns.14400

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Origin of the OAS–RNase L innate immune pathway before the rise of jawed vertebrates via molecular tinkering

Authors: Lingyu Chu , Zhen Gong , Wenqiang Wang , Guan-Zhu Han

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 37487089

Doi: 10.1073/pnas.2304687120

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Backbone-Installed Split Intein-Assisted Ligation for the Chemical Synthesis of Mirror-Image Proteins

Authors: Baochang Zhang, Yupeng Zheng, Guochao Chu, Xiangyu Deng, Tongyue Wang, Weiwei Shi, Yongkang Zhou, Shan Tang , Ji-Shen Zheng ， Lei Liu

Journal: Angew Chem Int Ed Engl

PubMed ID: 37357888

Doi: 10.1002/anie.202306270

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Enhancement of β-carotene content in Chlamydomonas reinhardtii by expressing bacterium-driven lycopene β-cyclase

Authors: Danqiong Huang , Chenglong Liu , Mingshan Su , Zhiyong Zeng , Chaogang Wang , Zhangli Hu , Sulin Lou , Hui Li

Journal: Biotechnol Biofuels Bioprod .

PubMed ID: 37573357

Doi: 10.1186/s13068-023-02377-1

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Crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing

Authors: Lenong Li, Xubiao Peng, Mansoor Batliwala, Marlene Bouvier

Journal: Nat Commun

PubMed ID: 37596268

Doi: 10.1038/s41467-023-40736-6

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Early proteostasis of caveolins synchronizes trafficking, degradation, and oligomerization to prevent toxic aggregation

Authors: Frederic Morales-Paytuví, Alba Fajardo, Carles Ruiz-Mirapeix, James Rae, Francesc Tebar, Marta Bosch, Carlos Enrich, Brett M Collins, Robert G Parton, Albert Pol

Journal: J Cell Biol

PubMed ID: 37526691

Doi: 10.1083/jcb.202204020

Products & Services: Proteins, Expression, Isolation and Analysis

Anti-SARS-CoV-2 Antibody Level Is Associated with a History of COVID-19 Infection and mRNA Vaccination in Patients with Diabetes

Authors: Is Asma'ul Haq Hataul, Nanny Natalia M Soetedjo, Josephine Debora, Marita Restie Tiara, Hofiya Djauhari, Evan Susandi, Bachti Alisjahbana, Rudi Wisaksana, Hikmat Permana

Journal: Vaccines (Basel)

PubMed ID: 37766101

Doi: 10.3390/vaccines11091424

Products & Services: Proteins, Expression, Isolation and Analysis

Interchangeability of the Assays Used to Assess the Activity of Anti-SARS-CoV-2 Monoclonal Antibodies

Authors: Brady T Hickerson, Alexey M Khalenkov, Tao Xie, David M Frucht, Dorothy E Scott, Natalia A Ilyushina

Journal: Viruses

PubMed ID: 37632039

Doi: 10.3390/v15081698

Products & Services: Proteins, Expression, Isolation and Analysis

Variation in microbial feature perception in the Rutaceae family with immune receptor conservation in citrus

Authors: Jessica Trinh, Tianrun Li, Jessica Y Franco, Tania Y Toruño, Danielle M Stevens, Shree P Thapa, Justin Wong, Rebeca Pineda, Emmanuel Ávila de Dios, Tracy L Kahn, Danelle K Seymour, Chandrika Ramadugu, Gitta L Coaker

Journal: Plant Physiol

PubMed ID: 37144828

Doi: 10.1093/plphys/kiad263

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NLRC4 promotes the cGAS-STING signaling pathway by facilitating CBL-mediated K63-linked polyubiquitination of TBK1

Authors: Rongzhao Zhang, Wenxian Yang, Huifang Zhu, Jingbo Zhai, Mengzhou Xue, Chunfu Zheng

Journal: J Med Virol

PubMed ID: 37537877

Doi: 10.1002/jmv.29013

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Gene co-option, duplication and divergence of cement proteins underpin the evolution of bioadhesives across barnacle life histories

Authors: Yue Him Wong, Niklas Dreyer, HaoCheng Liu, Yi Lan, Jamie J Chen, Jin Sun, Wei-Peng Zhang, Pei-Yuan Qian, Benny K K Chan

Journal: Mol Ecol

PubMed ID: 37584177

Doi: 10.1111/mec.17084

Products & Services: Proteins, Expression, Isolation and Analysis

Stabilisation of the RirA [4Fe-4S] cluster results in loss of iron-sensing function

Authors: Elizabeth Gray, Melissa Y Y Stewart, Libby Hanwell, Jason C Crack, Rebecca Devine, Clare E M Stevenson, Anne Volbeda, Andrew W B Johnston, Juan C Fontecilla-Camps, Matthew I Hutchings, Jonathan D Todd, Nick E Le Brun

Journal: Chem Sci

PubMed ID: 37736639

Doi: 10.1039/d3sc03020b

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Neutrophil-Mediated Tumor-Targeting Delivery System of Oncolytic Bacteria Combined with ICB for Melanoma Lung Metastasis Therapy

Authors: Lina Liu, Wenjie Xin, Qiang Li, Baolian Huang, Te Yin, Siqi Hua, Chen Yang, Chen Chen, Chao Han, Zichun Hua

Journal: Adv Sci (Weinh)

PubMed ID: 37565362

Doi: 10.1002/advs.202301835

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Soluble SARS-CoV-2 RBD and human ACE2 peptidase domain produced in Drosophila S2 cells show functions evoking virus-cell interface

Authors: Federico Carrión, Florencia Rammauro, Natalia Olivero-Deibe, Martín Fló, María Magdalena Portela, Analía Lima, Rosario Durán, Otto Pritsch, Sergio Bianchi

Journal: Protein Sci

PubMed ID: 37405395

Doi: 10.1002/pro.4721

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Garlic-derived exosome-like nanovesicles as a hepatoprotective agent alleviating acute liver failure by inhibiting CCR2/CCR5 signaling and inflammation

Authors: Xin Zhao, Fang Yin, Luoqin Fu, Yingyu Ma, Luyi Ye, Yilin Huang, Weijiao Fan, Wenxue Gao, Yu Cai, Xiaozhou Mou

Journal: Biomater Adv

PubMed ID: 37717364

Doi: 10.1016/j.bioadv.2023.213592

Products & Services: PCR Cloning and Subcloning

Rapid and ultrasensitive detection of mpox virus using CRISPR/Cas12b-empowered graphene field-effect transistors

Authors: LiWang;ChangXu;ShaohuiZhang ;ShangChen;HaoWang;ZhaojunDuan;OmarA.Al-Hartomy ;SwelmWageh;XiaoshaWen;YiLiu;YiLin;HuijiePu;ZhongjianXie;QuanLiu;HanZhang;DixianLuo

Journal: Applied Physics Reviews

Doi: 10.1063/5.0142494

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Rapid and automated design of two-component protein nanomaterials using ProteinMPNN

Authors: Robbert J de Haas, Natalie Brunette, Alex Goodson, Justas Dauparas, Sue Y Yi, Erin C Yang, Quinton Dowling, Hannah Nguyen, Alex Kang, Asim K Bera, Banumathi Sankaran, Renko de Vries, David Baker, Neil P King

Journal: biorxiv

PubMed ID: 37577478

Doi: 10.1101/2023.08.04.551935

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Flow-cytometric cell sorting coupled with UV mutagenesis for improving pectin lyase expression

Authors: Ke Fang , Jun Ma , Xinyu Wang, Ziting Xu , Ziyang Zhang , Piwu Li , Ruiming Wang, Junqing Wang, Chuying Sun and Ziyang Dong

Journal: Frontiers in bioengineering and biotechnology

Doi: 10.3389/fbioe.2023.1251342

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Multimodal, broadly neutralizing antibodies against SARS-CoV-2 identified by high-throughput native pairing of BCRs from bulk B cells

Authors: Gladys J Keitany , Benjamin E R Rubin , Meghan E Garrett , Andrea Musa , Jeff Tracy , Yu Liang , Peter Ebert , Amanda J Moore , Jonathan Guan , Erica Eggers , Ninnia Lescano , Ryan Brown , Adria Carbo , Hussein Al-Asadi , Travers Ching , Austin Day , Rebecca Harris , Charles Linkem , Dimitry Popov , Courtney Wilkins , Lianqu Li , Jiao Wang , Chuanxin Liu , Li Chen , Jennifer N Dines , Caroline Atyeo , Galit Alter , Lance Baldo , Anna Sherwood , Bryan Howie , Mark Klinger , Erik Yusko , Harlan S Robins , Sharon Benzeno , Amy E Gilbert

Journal: Cell Chem Biol .

PubMed ID: 37586370

Doi: 10.1016/j.chembiol.2023.07.011

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A near-infrared fluorescence-enhancing plasmonic biosensing microarray identifies soluble PD-L1 and ICAM-1 as predictive checkpoint biomarkers for cancer immunotherapy

Authors: Zhijun Lin, Mengyao Liu, Wei Xing, Fenghua Wang, Hongxia Zhang, Xiaoli Wei, Hans Schmitthenner, Xi Xie, Xiaojun Xia, Jiang Yang

Journal: Biosens Bioelectron

PubMed ID: 37683502

Doi: 10.1016/j.bios.2023.115633

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The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA1, BA2, and BA5

Authors: Huiping Shuai, Jasper Fuk-Woo Chan, Bingjie Hu, Yue Chai, Chaemin Yoon, Huan Liu, Yuanchen Liu, Jialu Shi, Tianrenzheng Zhu, Jing-Chu Hu, Ye-Fan Hu, Yuxin Hou, Xiner Huang, Terrence Tsz-Tai Yuen, Yang Wang, Jinjin Zhang, Yao Xia, Lin-Lei Chen, Jian-Piao Cai, Anna Jinxia Zhang, Shuofeng Yuan, Jie Zhou, Bao-Zhong Zhang, Jian-Dong Huang, Kwok-Yung Yuen, Kelvin Kai-Wang To, Hin Chu

Journal: EBioMedicine

PubMed ID: 37579626

Doi: 10.1016/j.ebiom.2023.104753

Products & Services: Proteins, Expression, Isolation and Analysis

ABBV-184: A Novel Survivin-specific TCR/CD3 Bispecific T-cell Engager is Active against Both Solid Tumor and Hematologic Malignancies

Authors: Adam S Chervin, Jennifer D Stone, Iwona Konieczna, Kelly M Calabrese, Ningyan Wang, Dipica Haribhai, Feng Dong, Michael K White, Luis E Rodriguez, Gail T Bukofzer, Paul A Ellis, Cormac Cosgrove, Claudie Hecquet, Jerry D Clarin, Joann P Palma, Edward B Reilly

Journal: Mol Cancer Ther

PubMed ID: 37294945

Doi: 10.1158/1535-7163.MCT-22-0770

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Expression analysis, clinical significance and potential function of PLXNB2 in acute myeloid leukaemia

Authors: Zhibo Guo, Dan Guo, Desheng Kong, Sicheng Bian, Linlin Zhao, Qi Li, Leilei Lin, Jiali Hao, Lili Sun, Yinghua Li

Journal: Mol Biol Rep

PubMed ID: 37632633

Doi: 10.1007/s11033-023-08721-w

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Biosynthesis of High-Active Hemoproteins by the Efficient Heme-Supply Pichia Pastoris Chassis

Authors: Fei Yu, Xinrui Zhao, Jingwen Zhou, Wei Lu, Jianghua Li, Jian Chen, Guocheng Du

Journal: Adv Sci (Weinh)

PubMed ID: 37649147

Doi: 10.1002/advs.202302826

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CircRNA-CIRH1A Promotes the Development of Osteosarcoma by Regulating PI3K/AKT and JAK2/STAT3 Signaling Pathways

Authors: Meng Zhang, Xiang Wang, Jianfeng Zhao, Jizhou Yan, Xiaodan He, Danxia Qin, Fang Liang, Kai Tong, Jianjian Wang

Journal: Mol Biotechnol

PubMed ID: 37608076

Doi: 10.1007/s12033-023-00812-0

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Id-neoantigen vaccine induces therapeutic CD8 T cells against multiple myeloma: H chain-loss escapees cause FLC MM

Authors: Marita Westhrin, Jana Blazevski, Ana Textor, Pegah Abdollahi, Ramakrishna Prabhu Gopalakrishnan, Linda Thuy Ngo, Peter Olaf Hofgaard, Julia Heinzelbecker, Sonja Bobic, Even Fossum, Heidi Cecilie Larsen Spång, Ranveig Braathen, Bjarne Bogen

Journal: J Immunother Cancer

PubMed ID: 37607769

Doi: 10.1136/jitc-2023-006944

Products & Services: Proteins, Expression, Isolation and Analysis

Obtaining high yield recombinant Enterococcus faecium nicotinate nucleotide adenylyltransferase for X-ray crystallography and biophysical studies

Authors: Olamide Jeje, Ramesh Pandian, Yasien Sayed, Ikechukwu Achilonu

Journal: Int J Biol Macromol

PubMed ID: 37544558

Doi: 10.1016/j.ijbiomac.2023.126066

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NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis

Authors: Quentin I B Lemaître, Natascha Bartsch, Ian U Kouzel, Henriette Busengdal, Gemma Sian Richards, Patrick R H Steinmetz, Fabian Rentzsch

Journal: Nat Commun

PubMed ID: 37563174

Doi: 10.1038/s41467-023-39789-4

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Role of the CagY antenna projection in Cag type IV secretion system activity

Authors: Sirena C Tran, Mark S McClain, Timothy L Cover

Journal: Infect Immun

PubMed ID: 37638724

Doi: 10.1128/iai.00150-23

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Correction to: An Immunoinformatics-Based Study of Mycobacterium tuberculosis Region of Difference-2 Uncharacterized Protein (Rv1987) as a Potential Subunit Vaccine Candidate for Preliminary Ex Vivo Analysis

Authors: Aregitu Mekuriaw Arega, Ajit Kumar Dhal, Kali Prasad Pattanaik, Sasmita Nayak, Rajani Kanta Mahapatra

Journal: Appl Biochem Biotechnol

PubMed ID: 37552364

Doi: 10.1007/s12010-023-04668-7

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The brassinosteroid-responsive protein OCTOPUS is a novel regulator of immune signaling

Authors: Kaitlyn N Greenwood, Courtney L King, Isabella Melena, Katherine A Stegemann, Maura Donnelly, Anna Childers, Raegan Mozal, Carina A Collins, Benjamin J Spears

Journal: Plant Direct

PubMed ID: 37638229

Doi: 10.1002/pld3.524

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SARS-CoV-2 ORF8 accessory protein is a virulence factor

Authors: M Bello-Perez, J Hurtado-Tamayo, A Z Mykytyn, M M Lamers, R Requena-Platek, D Schipper, D Muñoz-Santos, J Ripoll-Gómez, A Esteban, P J Sánchez-Cordón, L Enjuanes, B L Haagmans, I Sola

Journal: MBio

PubMed ID: 37623322

Doi: 10.1128/mbio.00451-23

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Subtilisin 3 production from Microsporum canis is independent of keratin substrate availability

Authors: Alex E Moskaluk, Lauren Darlington, Sue VandeWoude

Journal: J Basic Microbiol

PubMed ID: 37551993

Doi: 10.1002/jobm.202300125

Products & Services: Proteins, Expression, Isolation and Analysis

Non-IgE-reactive allergen peptides deteriorate the skin barrier in house dust mite-sensitized atopic dermatitis patients

Authors: Karin Pfisterer, Matthias Wielscher, David Samardzic, Pauline Weinzettl, Dorte Symmank, Lisa E Shaw, Raffaela Campana, Huey-Jy Huang, Matthias Farlik, Christine Bangert, Susanne Vrtala, Rudolf Valenta, Wolfgang Weninger

Journal: Front Cell Dev Biol

PubMed ID: 37675143

Doi: 10.3389/fcell.2023.1240289

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Structure of Orthoreovirus RNA Chaperone σNS, a Component of Viral Replication Factories

Authors: Boyang Zhao, Liya Hu, Soni Kuandal, Neetu Neetu, Christopher Lee, Xayathed Somoulay, Banumathi Sankaran, Gwen M Taylor, Terence S Dermody, B V Venkataram Prasad

Journal: biorxiv

PubMed ID: 37577609

Doi: 10.1101/2023.07.31.551319

Products & Services: Proteins, Expression, Isolation and Analysis

Mining and Characterization of Indolethylamine N‑Methyltransferases in Amphibian Toad Bufo gargarizans

Authors: An-An Zhang , Qing-Li He , Qunfei Zhao

Journal: Biochemistry .

PubMed ID: 37490721

Doi: 10.1021/acs.biochem.3c00229

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Mass-produced gram-negative bacterial outer membrane vesicles activate cancer antigen-specific stem-like CD8 T cells which enables an effective combination immunotherapy with anti-PD-1

Authors: Solchan Won, Changjin Lee, Seoyoon Bae, Jaemin Lee, Dongsic Choi, Min-Gang Kim, Sunghyun Song, Jaewook Lee, Eunhye Kim, HaYoung Shin, Anita Basukala, Tae Ryong Lee, Dong-Sup Lee, Yong Song Gho

Journal: J Extracell Vesicles

PubMed ID: 37563797

Doi: 10.1002/jev2.12357

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A mechanistic insight for the biosynthesis of N,N-dimethyltryptamine: An ONIOM theoretical approach

Authors: Lucas Pinheiro Coutinho, Sérgio Ruschi Bergamachi Silva, Pedro de Lima-Neto, Norberto de Kássio Vieira Monteiro

Journal: Biochem Biophys Res Commun

PubMed ID: 37640000

Doi: 10.1016/j.bbrc.2023.08.043

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Sucrose-induced hyperglycemia dysregulates intestinal zinc metabolism and integrity: risk factors for chronic diseases

Authors: Samuel Blake Mitchell, Yu-Han Hung, Trista Lee Thorn, Jiaqi Zou, Filiz Baser, Sukru Gulec, Celeste Cheung, Tolunay Beker Aydemir

Journal: Front Nutr

PubMed ID: 37637953

Doi: 10.3389/fnut.2023.1220533

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Structure, catalysis, chitin transport, and selective inhibition of chitin synthase

Authors: Dan-Dan Chen, Zhao-Bin Wang, Le-Xuan Wang, Peng Zhao, Cai-Hong Yun, Lin Bai

Journal: Nat Commun

PubMed ID: 37553334

Doi: 10.1038/s41467-023-40479-4

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Sm-like protein Rof inhibits transcription termination factor ρ by binding site obstruction and conformational insulation

Authors: Nelly Said, Mark Finazzo, Tarek Hilal, Bing Wang, Tim Luca Selinger, Daniela Gjorgjevikj, Irina Artsimovitch, Markus C Wahl

Journal: biorxiv

PubMed ID: 37693585

Doi: 10.1101/2023.08.30.555460

Products & Services: Proteins, Expression, Isolation and Analysis

Performance upgrade of a microbial explosives' sensor strain by screening a high throughput saturation library of a transcriptional regulator

Authors: Lidor David, Etai Shpigel, Itay Levin, Shaked Moshe, Lior Zimmerman, Shilat Dadon-Simanowitz, Benjamin Shemer, Shon A Levkovich, Liraz Larush, Shlomo Magdassi, Shimshon Belkin

Journal: Comput Struct Biotechnol J

PubMed ID: 37701016

Doi: 10.1016/j.csbj.2023.08.017

Products & Services: Proteins, Expression, Isolation and Analysis

A conserved family of immune effectors cleaves cellular ATP upon viral infection

Authors: Francois Rousset, Erez Yirmiya, Shahar Nesher, Alexander Brandis, Tevie Mehlman, Maxim Itkin, Sergey Malitsky, Adi Millman, Sarah Melamed, Rotem Sorek

Journal: Cell

PubMed ID: 37595565

Doi: 10.1016/j.cell.2023.07.020

Products & Services: Proteins, Expression, Isolation and Analysis

Nanograms of SARS-CoV-2 spike protein delivered by exosomes induce potent neutralization of both delta and omicron variants

Authors: Mafalda Cacciottolo, Yujia Li, Justin B Nice, Michael J LeClaire, Ryan Twaddle, Ciana L Mora, Stephanie Y Adachi, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun

Journal: PLoS ONE

PubMed ID: 37607200

Doi: 10.1371/journal.pone.0290046

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Nona-Arginine Mediated Anti-E6 ShRNA Delivery Suppresses the Growth of Hela Cells in vitro

Authors: Razieh Taghizadeh Pirposhteh, Ehsan Arefian, Arash Arashkia, Nasir Mohajel

Journal: Iran Biomed J

PubMed ID: 37978985

Doi: 10.52547/ibj.3963

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Synergistic Screening of Peptide-Based Biotechnological Drug Candidates for Neurodegenerative Diseases Using Yeast Display and Phage Display

Authors: Cemile Elif Özçelik, Özge Beğli, Ahmet Hınçer, Recep Erdem Ahan, Mehmet Seçkin Kesici, Oğuzhan Oğuz, Talip Serkan Kasırga, Salih Özçubukçu, Urartu Özgür Şafak Şeker

Journal: ACS Chem Neurosci

PubMed ID: 37638647

Doi: 10.1021/acschemneuro.3c00248

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A potent and durable malaria transmission-blocking vaccine designed from a single-component 60-copy Pfs230D1 nanoparticle

Authors: Nichole D Salinas, Rui Ma, Thayne H Dickey, Holly McAleese, Tarik Ouahes, Carole A Long, Kazutoyo Miura, Lynn E Lambert, Niraj H Tolia

Journal: npj Vaccines

PubMed ID: 37596283

Doi: 10.1038/s41541-023-00709-8

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Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair

Authors: Nikolaos Parisis, Pablo D Dans, Muhammad Jbara, Balveer Singh, Diane Schausi-Tiffoche, Diego Molina-Serrano, Isabelle Brun-Heath, Denisa Hendrychová, Suman Kumar Maity, Diana Buitrago, Rafael Lema, Thiziri Nait Achour, Simona Giunta, Michael Girardot, Nicolas Talarek, Valérie Rofidal, Katerina Danezi, Damien Coudreuse, Marie-Noëlle Prioleau, Robert Feil, Modesto Orozco, Ashraf Brik, Pei-Yun Jenny Wu, Liliana Krasinska, Daniel Fisher

Journal: Nat Commun

PubMed ID: 37607906

Doi: 10.1038/s41467-023-40843-4

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Ester Bond: Chemically Labile Yet Mechanically Stable

Authors: Hai Lei, Quan Ma, Zhangxia Wang, Di Zhang, Xiaoyu Huang, Meng Qin, Haibo Ma, Wei Wang, Yi Cao

Journal: ACS Nano

PubMed ID: 37646337

Doi: 10.1021/acsnano.3c03807

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Rapid Determination of the Topology of Oligomeric α-Helical Membrane Proteins by Water- and Lipid-Edited Methyl NMR

Authors: Iva Sučec, Nadia El Mammeri, Aurelio J Dregni, Mei Hong

Journal: J Phys Chem B

PubMed ID: 37606918

Doi: 10.1021/acs.jpcb.3c05295

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design of buttressed loops for sculpting protein functions

Authors: Hanlun Jiang, Kevin M Jude, Kejia Wu, Jorge Fallas, George Ueda, T J Brunette, Derrick Hicks, Harley Pyles, Aerin Yang, Lauren Carter, Mila Lamb, Xinting Li, Paul M Levine, Lance Stewart, K Christopher Garcia, David Baker

Journal: biorxiv

PubMed ID: 37662224

Doi: 10.1101/2023.08.22.554384

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Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer's Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice

Authors: Yang Zhu, Hao Huang, Zhi Chen, Yong Tao, Ling-Yi Liao, Shi-Hao Gao, Yan-Jiang Wang, Chang-Yue Gao

Journal: Neurosci Bull

PubMed ID: 37578635

Doi: 10.1007/s12264-023-01098-7

Products & Services: Proteins, Expression, Isolation and Analysis

Anti-Tumor Immunity Induced by a Ternary Membrane System Derived From Cancer Cells, Dendritic Cells, and Bacteria

Authors: He Ren , Jiexin Li , Jingyu Zhang , Jingang Liu , Xingyue Yang , Nan Zhang , Qian Qiu , Dan Li , Yue Yu , Xiaofeng Liu , Jonathan F Lovell , Yumiao Zhang

Journal: Small .

PubMed ID: 37603007

Doi: 10.1002/smll.202302756

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Development of a novel method for diagnosis of fasciolosis based on cathepsin L7 in ruminants

Authors: Jing-Zhi Gong, Yi-Min Fan, Wanzhe Yuan, Ming Pan, Dandan Liu, Jian-Ping Tao, Si-Yang Huang

Journal: Vet Parasitol

PubMed ID: 37657153

Doi: 10.1016/j.vetpar.2023.110021

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The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathway

Authors: Guiying Kuang, Zhigang Shu, Chunli Zhu, Hongbing Li, Cheng Zhang

Journal: Transl Neurosci

PubMed ID: 37635842

Doi: 10.1515/tnsci-2022-0302

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In skeletal muscle and neural crest cells, SMCHD1 regulates biological pathways relevant for Bosma syndrome and facioscapulohumeral dystrophy phenotype

Authors: Camille Laberthonnière, Mégane Delourme, Raphaël Chevalier, Camille Dion, Benjamin Ganne, David Hirst, Leslie Caron, Pierre Perrin, José Adélaïde, Max Chaffanet, Shifeng Xue, Karine Nguyen, Bruno Reversade, Jérôme Déjardin, Anaïs Baudot, Jérôme D Robin, Frédérique Magdinier

Journal: Nucleic Acids Res

PubMed ID: 37334829

Doi: 10.1093/nar/gkad523

Products & Services: Proteins, Expression, Isolation and Analysis

Structural and dynamic heterogeneity in associative networks formed by artificially engineered protein polymers

Authors: Ameya Rao, Bradley D Olsen

Journal: Soft Matter

PubMed ID: 37560814

Doi: 10.1039/d3sm00150d

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Design of an alternate antibody fragment format that can be produced in the cytoplasm of Escherichia coli

Authors: Aatir A Tungekar, Lloyd W Ruddock

Journal: Sci Rep

PubMed ID: 37648872

Doi: 10.1038/s41598-023-41525-3

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TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6

Authors: Yiqi Zhao, Yongxu Lu, Samuel Richardson, Meghna Sreekumar, Jonas D Albarnaz, Geoffrey L Smith

Journal: Nature

PubMed ID: 37558876

Doi: 10.1038/s41586-023-06401-0

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Cell-free transcription-translation system: a dual read-out assay to characterize riboswitch function

Authors: Jasleen Kaur Bains, Nusrat Shahin Qureshi, Betül Ceylan, Anna Wacker, Harald Schwalbe

Journal: Nucleic Acids Res

PubMed ID: 37409574

Doi: 10.1093/nar/gkad574

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The Expansin Gene Is a Direct Target of CsLOB1 in Citrus

Authors: Reinaldo Rodrigues de Souza-Neto, Fernanda Nogales da Costa Vasconcelos, Doron Teper, Isis Gabriela Barbosa Carvalho, Marco Aurelio Takita, Celso Eduardo Benedetti, Nian Wang, Alessandra Alves de Souza

Journal: Phytopathology

PubMed ID: 36825333

Doi: 10.1094/PHYTO-11-22-0424-R

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Heterologous Expression and Partial Characterization of a Putative Opine Dehydrogenase from a Metagenomic Sequence of Desulfohalobium retbaense

Authors: Nevena Kaličanin, Ana Marija Balaž, Olivera Prodanović, Radivoje Prodanović

Journal: Chembiochem

PubMed ID: 37531452

Doi: 10.1002/cbic.202300414

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Sequential Targeting Hybrid Nanovesicles Composed of Chimeric Antigen Receptor T-Cell-Derived Exosomes and Liposomes for Enhanced Cancer Immunochemotherapy

Authors: Tianchuan Zhu, Zhenxing Chen, Guanmin Jiang, Xi Huang

Journal: ACS Nano

PubMed ID: 37624742

Doi: 10.1021/acsnano.3c03456

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Hybrid structural modeling of alloantibody binding to human leukocyte antigen with rapid and reproducible cross-linking mass spectrometry

Authors: Zheng Ser, Yue Gu, Jiawei Yap, Yan Ting Lim, Shi Mei Wang, Maryam Hamidinia, Tanusya Murali Murali, Ragini Kumar, Nicholas Rj Gascoigne, Paul A MacAry, Radoslaw M Sobota

Journal: Cell Rep Methods

PubMed ID: 37751693

Doi: 10.1016/j.crmeth.2023.100569

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A new compact adenine base editor generated through deletion of HNH and REC2 domain of SpCas9

Authors: Yuqiang Qian , Di Wang , Wenchao Niu , Ding Zhao , Jinze Li , Zhiquan Liu , Xun Gao , Yang Han , Liangxue Lai , Zhanjun Li

Journal: BMC Biol .

PubMed ID: 37434184

Doi: 10.1186/s12915-023-01644-9

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Glc7/PP1 dephosphorylates histone H3T11 to regulate autophagy and telomere silencing in response to nutrient availability

Authors: Xinyu Zhang, Qi Yu, Yinsheng Wu, Yuan Zhang, Yi He, Rongsha Wang, Xilan Yu,Shanshan Li

Journal: Cell Discovery

Doi: 10.1038/s41421-023-00551-1

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Chemo-enzymatic cascades producing 2,5- furandicarboxylic acid precursors via D-gluconate “barbell oxidation” and dehydration

Authors: Jiao Chen, a,b Jiali Cai,c Feng Sha,d Wenjun Sun,a Xilei Lyu,e Yonghui Chang,f Fei Cao, Lili Zhao, Hongli Wu and Pingkai Ouyang

Journal: Green Chem.

Doi: 10.1039/d3gc01493b

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Tetraspanin CD9-derived peptides inhibit Pseudomonas aeruginosa corneal infection and aid in wound healing of corneal epithelial cells

Authors: Praveen Kumar Jadi, Alpana Dave, Rahaf Issa, Khatija Tabbasum, Katarzyna Okurowska, Apurwa Samarth, Lucy Urwin, Luke R Green, Lynda J Partridge, Sheila MacNeil, Prashant Garg, Peter N Monk, Sanhita Roy

Journal: Ocul Surf

PubMed ID: 37406881

Doi: 10.1016/j.jtos.2023.07.001

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A positively tuned voltage indicator for extended electrical recordings in the brain

Authors: S Wenceslao Evans, Dong-Qing Shi, Mariya Chavarha, Mark H Plitt, Jiannis Taxidis, Blake Madruga, Jiang Lan Fan, Fuu-Jiun Hwang, Siri C van Keulen, Carl-Mikael Suomivuori, Michelle M Pang, Sharon Su, Sungmoo Lee, Yukun A Hao, Guofeng Zhang, Dongyun Jiang, Lagnajeet Pradhan, Richard H Roth, Yu Liu, Conor C Dorian, Austin L Reese, Adrian Negrean, Attila Losonczy, Christopher D Makinson, Sui Wang, Thomas R Clandinin, Ron O Dror, Jun B Ding, Na Ji, Peyman Golshani, Lisa M Giocomo, Guo-Qiang Bi, Michael Z Lin

Journal: Nat Methods

PubMed ID: 37429962

Doi: 10.1038/s41592-023-01913-z

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Process Robustness in Lipid Nanoparticle Production: A Comparison of Microfluidic and Turbulent Jet Mixing

Authors: Matthew N O'Brien Laramy, Antonio P Costa, Yareli Maciel Cebrero, Johnson Joseph, Apoorva Sarode, Nanzhi Zang, Lee Joon Kim, Kate Hofmann, Shirley Wang, Alexandre Goyon, Stefan G Koenig, Michal Hammel, Greg L Hura

Journal: Mol Pharm

PubMed ID: 37462906

Doi: 10.1021/acs.molpharmaceut.3c00390

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Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

Authors: Abiola O Olaitan, Chetna Dureja, Madison A Youngblom, Madeline A Topf, Wan-Jou Shen, Anne J Gonzales-Luna, Aditi Deshpande, Kirk E Hevener, Jane Freeman, Mark H Wilcox, Kelli L Palmer, Kevin W Garey, Caitlin S Pepperell, Julian G Hurdle

Journal: Nat Commun

PubMed ID: 37438331

Doi: 10.1038/s41467-023-39429-x

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Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection

Authors: Gregory M Martin, Jonathan L Torres, Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Grace Gibson, Re'em Moskovitz, Nathan Beutler, Diana D Jung, Jeffrey Copps, Wen-Hsin Lee, Gonzalo Gonzalez-Paez, Daniel Emerling, Randall S MacGill, Emily Locke, C Richter King, Fidel Zavala, Ian A Wilson, Andrew B Ward

Journal: Nat Commun

PubMed ID: 37507365

Doi: 10.1038/s41467-023-40151-x

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Effective virus-specific T-cell therapy for high-risk SARS-CoV-2 infections in hematopoietic stem cell transplant recipients: initial case studies and literature review

Authors: László Gopcsa, Marienn Réti, Hajnalka Andrikovics, Ilona Bobek, Gabriella Bekő, Judit Bogyó, Andrea Ceglédi, Katalin Dobos, Laura Giba-Kiss, István Jankovics, Orsolya Kis, Botond Lakatos, Dóra Mathiász, Nóra Meggyesi, Gottfried Miskolczi, Noémi Németh, Melinda Paksi, Alexandra Riczu, János Sinkó, Bálint Szabó, Anikó Szilvási, János Szlávik, Szabolcs Tasnády, Péter Reményi, István Vályi-Nagy

Journal: Geroscience

PubMed ID: 37414968

Doi: 10.1007/s11357-023-00858-7

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Development of chimeric protein as a multivalent vaccine for human Kinetoplastid infections: Chagas disease and leishmaniasis

Authors: Marianna de Carvalho Clímaco, Luiza Almeida de Figueiredo, Rayane Cristina Lucas, Guilherme Rafael Gomide Pinheiro, Luísa Mourão Dias Magalhães, Ana Laura Grossi de Oliveira, Raquel Martins Almeida, Fernando Sérgio Barbosa, Daniella Castanheira Bartholomeu, Lilian Lacerda Bueno, Tiago Antonio Mendes, Bin Zhan, Kathryn Marie Jones, Peter Hotez, Maria Elena Bottazzi, Fabrício Marcus Silva Oliveira, Ricardo Toshio Fujiwara

Journal: Vaccine

PubMed ID: 37479612

Doi: 10.1016/j.vaccine.2023.07.020

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Integrated analysis and validation of TRIM23/p53 signaling pathway in hepatic stellate cells ferroptosis and liver fibrosis

Authors: Jie Chen, Rui Zhang, Feng Li, Shengli Lin, Jian Wang

Journal: Dig Liver Dis

PubMed ID: 37495427

Doi: 10.1016/j.dld.2023.07.010

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Tetracycline-modifying enzyme SmTetX from Stenotrophomonas maltophilia

Authors: Martin Malý, Petr Kolenko, Jan Stránský, Leona Švecová, Jarmila Dušková, Tomáš Koval', Tereza Skálová, Mária Trundová, Kristýna Adámková, Jiří Černý, Paulína Božíková, Jan Dohnálek

Journal: Acta Crystallogr F Struct Biol Commun

PubMed ID: 37405486

Doi: 10.1107/S2053230X23005381

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PSW1, an LRR receptor kinase, regulates pod size in peanut

Authors: Kunkun Zhao, Long Wang, Ding Qiu, Zenghui Cao, Kuopeng Wang, Zhan Li, Xiaoxuan Wang, Jinzhi Wang, Qian Ma, Di Cao, Yinyao Qi, Kai Zhao, Fangping Gong, Zhongfeng Li, Rui Ren, Xingli Ma, Xingguo Zhang, Feng Yu, Dongmei Yin

Journal: Plant Biotechnol J

PubMed ID: 37431286

Doi: 10.1111/pbi.14117

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Aflatoxin B1 Exacerbates Genomic Instability and Apoptosis in the BTBR Autism Mouse Model via Dysregulating DNA Repair Pathway

Authors: Ali A Alshamrani, Mohammad Y Alwetaid, Mohammed A Al-Hamamah, Mohamed S M Attia, Sheikh F Ahmad, Majed A Algonaiah, Ahmed Nadeem, Mushtaq A Ansari, Saleh A Bakheet, Sabry M Attia

Journal: Toxics

PubMed ID: 37505601

Doi: 10.3390/toxics11070636

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Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice

Authors: Liming Yu, Lin Xu, Haiyan Chu, Jun Peng, Anastasia Sacharidou, Hsi-Hsien Hsieh, Ada Weinstock, Sohaib Khan, Liqian Ma, José Gabriel Barcia Durán, Jeffrey McDonald, Erik R Nelson, Sunghee Park, Donald P McDonnell, Kathryn J Moore, Lily Jun-Shen Huang, Edward A Fisher, Chieko Mineo, Linzhang Huang, Philip W Shaul

Journal: Nat Commun

PubMed ID: 37491347

Doi: 10.1038/s41467-023-39586-z

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gene knockdown induces insect cell lines death and level increases of intracellular calcium ions

Authors: Jiqiang Song, Yanping Yu, Zhichao Yan, Shan Xiao, Xianxin Zhao, Fang Wang, Qi Fang, Gongyin Ye

Journal: Front Physiol

PubMed ID: 37485065

Doi: 10.3389/fphys.2023.1217954

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CD38-Specific CAR Integrated into CD38 Locus Driven by Different Promoters Causes Distinct Antitumor Activities of T and NK Cells

Authors: Chan Liao, Yajie Wang, Yanjie Huang, Yanting Duan, Yan Liang, Jiangqing Chen, Jie Jiang, Kai Shang, Chun Zhou, Ying Gu, Nan Liu, Xun Zeng, Xiaofei Gao, Yongmin Tang, Jie Sun

Journal: Adv Sci (Weinh)

PubMed ID: 37485647

Doi: 10.1002/advs.202207394

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The Effect of Long-Term Passage on Porcine SMCs' Function and the Improvement of TGF-β1 on Porcine SMCs' Secretory Function in Late Passage

Authors: Yan-Yan Zheng, Ze-Nan Hu, Zheng Liu, Yi-Chen Jiang, Ren-Peng Guo, Shi-Jie Ding, Guang-Hong Zhou

Journal: Foods

PubMed ID: 37509774

Doi: 10.3390/foods12142682

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Creation of a Peptide Antagonist of the GFRAL-RET Receptor Complex for the Treatment of GDF15-Induced Malaise

Authors: Tito Borner, Ian C Tinsley, Brandon T Milliken, Sarah A Doebley, Nicholas R Najjar, Deborah J Kerwood, Bart C De Jonghe, Matthew R Hayes, Robert P Doyle

Journal: J Med Chem

PubMed ID: 37506293

Doi: 10.1021/acs.jmedchem.3c00667

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Hierarchical design of pseudosymmetric protein nanoparticles

Authors: Quinton M Dowling, Young-Jun Park, Neil Gerstenmaier, Erin C Yang, Adam Wargacki, Yang Hsia, Chelsea N Fries, Rashmi Ravichandran, Carl Walkey, Anika Burrell, David Veesler, David Baker, Neil P King

Journal: Res Sq

PubMed ID: 37503272

Doi: 10.21203/rs.3.rs-3074553/v1

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Structural and Kinetic Characterization of the SpeG Spermidine/Spermine -acetyltransferase from Methicillin-Resistant USA300

Authors: Sofiya Tsimbalyuk, Aleksander Shornikov, Parul Srivastava, Van Thi Bich Le, Imani Warren, Yogesh B Khandokar, Misty L Kuhn, Jade K Forwood

Journal: Cells

PubMed ID: 37508494

Doi: 10.3390/cells12141829

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Mapping of corticotropin-releasing factor, receptors, and binding protein mRNA in the chicken telencephalon throughout development

Authors: Alek H Metwalli, Alessandra Pross, Ester Desfilis, Antonio Abellán, Loreta Medina

Journal: J Comp Neurol

PubMed ID: 37393534

Doi: 10.1002/cne.25517

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Polyphenol Oxidase Products Are Priming Agents for LPMO Peroxygenase Activity

Authors: Caio de Oliveira Gorgulho Silva, Marlene Vuillemin, Mirjam A Kabel, Willem J H van Berkel, Anne S Meyer, Jane W Agger

Journal: ChemSusChem

PubMed ID: 37278305

Doi: 10.1002/cssc.202300559

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Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry

Authors: Susan A Leonhardt, Michael D Purdy, Jonathan R Grover, Ziwei Yang, Sandra Poulos, William E McIntire, Elizabeth A Tatham, Satchal K Erramilli, Kamil Nosol, Kin Kui Lai, Shilei Ding, Maolin Lu, Pradeep D Uchil, Andrés Finzi, Alan Rein, Anthony A Kossiakoff, Walther Mothes, Mark Yeager

Journal: Nat Commun

PubMed ID: 37474505

Doi: 10.1038/s41467-023-39262-2

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Biomimetic Mineralized CRISPR/Cas RNA Nanoparticles forEfficient Tumor-Specific Multiplex Gene Editing

Authors: Yan Liang , Jingge Zhang , Chenlu Xu , Jinjin Wang , Wenshuai Han , Jiali Yang , Sixuan Wu , Jingyi An , Junjie Liu , Zhenzhong Zhang , Jinjin Shi , Kaixiang Zhang

Journal: ACS Nano .

PubMed ID: 37481734

Doi: 10.1021/acsnano.3c04116

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Nanoengineered mesenchymal stem cell therapy for pulmonary fibrosis in young and aged mice

Authors: Meng-Meng Han , Xing-Yue He , Ling Tang , Liang Qi , Ming-Yuan Yang , Yi Wang , Lei Xing , Jee-Heon Jeong , Hu-Lin Jiang

Journal: Sci Adv .

PubMed ID: 37467328

Doi: 10.1126/sciadv.adg5358

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Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses

Authors: Xiuyuan Ou , Ge Xu , Pei Li , Yan Liu , Fuwen Zan , Pan Liu , Jiaxin Hu , Xing Lu , Siwen Dong , Yao Zhou , Zhixia Mu , Zhiqiang Wu , Jianwei Wang , Qi Jin , Pinghuang Liu , Jian Lu , Xiangxi Wang , Zhaohui Qian

Journal: Cell Discov .

PubMed ID: 37507385

Doi: 10.1038/s41421-023-00581-9

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A neural cell adhesion molecule from oyster Crassostrea gigas: Molecular identification and immune functional characterization

Authors: Xue Qiao, Conghui Liu, Weilin Wang, Chuanyan Yang, Meijia Li, Qilin Yi, Ning Kong, Limei Qiu, Xiyang Liu, Lingling Wang, Linsheng Song

Journal: Int J Biol Macromol

PubMed ID: 37429340

Doi: 10.1016/j.ijbiomac.2023.125756

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Engineering the HK97 virus-like particle as a nanoplatform for biotechnology applications

Authors: Michael D Woods, Matthew Cali, Bubacarr Ceesay, Shandis Fancher, Gaini Ibrasheva, Suefian Kandeel, Manon Nassar, Ali Azghani, Brent Bill, Dustin P Patterson

Journal: J Mater Chem B

PubMed ID: 37345352

Doi: 10.1039/d3tb00318c

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MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice

Authors: Nana Li, Junjie Yu, Meiyang Zhou, Fanyi Qiu, Xiao Wang, Zhengpin Wang

Journal: Biochem Biophys Res Commun

PubMed ID: 37451217

Doi: 10.1016/j.bbrc.2023.07.013

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Structural and biochemical characterization of Schlafen11 N-terminal domain

Authors: Pengjiao Hou, Wei Hao, Bo Qin, Mengyun Li, Rong Zhao, Sheng Cui

Journal: Nucleic Acids Res

PubMed ID: 37293979

Doi: 10.1093/nar/gkad509

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An Immunoinformatics-Based Study of Mycobacterium tuberculosis Region of Difference-2 Uncharacterized Protein (Rv1987) as a Potential Subunit Vaccine Candidate for Preliminary Ex Vivo Analysis

Authors: Aregitu Mekuriaw Arega, Ajit Kumar Dhal, Kali Prasad Pattanaik, Sasmita Nayak, Rajani Kanta Mahapatra

Journal: Appl Biochem Biotechnol

PubMed ID: 37498378

Doi: 10.1007/s12010-023-04658-9

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A Biosafety Study of Human Umbilical Cord Blood Mononuclear Cells Transduced with Adenoviral Vector Carrying Human Vascular Endothelial Growth Factor cDNA In Vitro

Authors: Ilnur I Salafutdinov , Dilara Z Gatina , Maria I Markelova , Ekaterina E Garanina , Sergey Yu Malanin , Ilnaz M Gazizov , Andrei A Izmailov , Albert A Rizvanov , Rustem R Islamov , András Palotás , Zufar Z Safiullov

Journal: Biomedicines .

PubMed ID: 37509661

Doi: 10.3390/biomedicines11072020

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Actions of a Novel Bacterial Topoisomerase Inhibitor against Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks

Authors: Soziema E Dauda, Jessica A Collins, Jo Ann W Byl, Yanran Lu, Jack C Yalowich, Mark J Mitton-Fry, Neil Osheroff

Journal: Int J Mol Sci

PubMed ID: 37569485

Doi: 10.3390/ijms241512107

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Accurate identification and discrimination of serovar Gallinarum biovars Gallinarum and Pullorum by a multiplex PCR based on the new genes of and

Authors: Li Song, Ruimeng Tan, Dan Xiong, Xinan Jiao, Zhiming Pan

Journal: Front Vet Sci

PubMed ID: 37476820

Doi: 10.3389/fvets.2023.1220118

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A mass spectrometry assay for detection of endogenous and lentiviral engineered hemoglobin in cultured cells and sickle cell disease mice

Authors: Xuejun Wang, William M McKillop, Theresa A Dlugi, Mary L Faber, Juliana Alvarez-Argote, Christopher B Chambers, Andrew Wilber, Jeffrey A Medin

Journal: J Gene Med

PubMed ID: 37455676

Doi: 10.1002/jgm.3567

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