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Chemo-enzymatic cascades producing 2,5- furandicarboxylic acid precursors via D-gluconate “barbell oxidation” and dehydration

Authors: Jiao Chen, a,b Jiali Cai,c Feng Sha,d Wenjun Sun,a Xilei Lyu,e Yonghui Chang,f Fei Cao, Lili Zhao, Hongli Wu and Pingkai Ouyang

Journal: Green Chem.

Doi: 10.1039/d3gc01493b

Products & Services: Gene Synthesis

Tetraspanin CD9-derived peptides inhibit Pseudomonas aeruginosa corneal infection and aid in wound healing of corneal epithelial cells

Authors: Praveen Kumar Jadi, Alpana Dave, Rahaf Issa, Khatija Tabbasum, Katarzyna Okurowska, Apurwa Samarth, Lucy Urwin, Luke R Green, Lynda J Partridge, Sheila MacNeil, Prashant Garg, Peter N Monk, Sanhita Roy

Journal: Ocul Surf

PubMed ID: 37406881

Doi: 10.1016/j.jtos.2023.07.001

Products & Services: Molecular Biology Reagents

A positively tuned voltage indicator for extended electrical recordings in the brain

Authors: S Wenceslao Evans, Dong-Qing Shi, Mariya Chavarha, Mark H Plitt, Jiannis Taxidis, Blake Madruga, Jiang Lan Fan, Fuu-Jiun Hwang, Siri C van Keulen, Carl-Mikael Suomivuori, Michelle M Pang, Sharon Su, Sungmoo Lee, Yukun A Hao, Guofeng Zhang, Dongyun Jiang, Lagnajeet Pradhan, Richard H Roth, Yu Liu, Conor C Dorian, Austin L Reese, Adrian Negrean, Attila Losonczy, Christopher D Makinson, Sui Wang, Thomas R Clandinin, Ron O Dror, Jun B Ding, Na Ji, Peyman Golshani, Lisa M Giocomo, Guo-Qiang Bi, Michael Z Lin

Journal: Nat Methods

PubMed ID: 37429962

Doi: 10.1038/s41592-023-01913-z

Products & Services: Molecular Biology Reagents

Process Robustness in Lipid Nanoparticle Production: A Comparison of Microfluidic and Turbulent Jet Mixing

Authors: Matthew N O'Brien Laramy, Antonio P Costa, Yareli Maciel Cebrero, Johnson Joseph, Apoorva Sarode, Nanzhi Zang, Lee Joon Kim, Kate Hofmann, Shirley Wang, Alexandre Goyon, Stefan G Koenig, Michal Hammel, Greg L Hura

Journal: Mol Pharm

PubMed ID: 37462906

Doi: 10.1021/acs.molpharmaceut.3c00390

Products & Services: Proteins, Expression, Isolation and Analysis

Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

Authors: Abiola O Olaitan, Chetna Dureja, Madison A Youngblom, Madeline A Topf, Wan-Jou Shen, Anne J Gonzales-Luna, Aditi Deshpande, Kirk E Hevener, Jane Freeman, Mark H Wilcox, Kelli L Palmer, Kevin W Garey, Caitlin S Pepperell, Julian G Hurdle

Journal: Nat Commun

PubMed ID: 37438331

Doi: 10.1038/s41467-023-39429-x

Products & Services: Molecular Biology Reagents

Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection

Authors: Gregory M Martin, Jonathan L Torres, Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Grace Gibson, Re'em Moskovitz, Nathan Beutler, Diana D Jung, Jeffrey Copps, Wen-Hsin Lee, Gonzalo Gonzalez-Paez, Daniel Emerling, Randall S MacGill, Emily Locke, C Richter King, Fidel Zavala, Ian A Wilson, Andrew B Ward

Journal: Nat Commun

PubMed ID: 37507365

Doi: 10.1038/s41467-023-40151-x

Products & Services: Molecular Biology Reagents

Effective virus-specific T-cell therapy for high-risk SARS-CoV-2 infections in hematopoietic stem cell transplant recipients: initial case studies and literature review

Authors: László Gopcsa, Marienn Réti, Hajnalka Andrikovics, Ilona Bobek, Gabriella Bekő, Judit Bogyó, Andrea Ceglédi, Katalin Dobos, Laura Giba-Kiss, István Jankovics, Orsolya Kis, Botond Lakatos, Dóra Mathiász, Nóra Meggyesi, Gottfried Miskolczi, Noémi Németh, Melinda Paksi, Alexandra Riczu, János Sinkó, Bálint Szabó, Anikó Szilvási, János Szlávik, Szabolcs Tasnády, Péter Reményi, István Vályi-Nagy

Journal: Geroscience

PubMed ID: 37414968

Doi: 10.1007/s11357-023-00858-7

Products & Services: Serology SARS-Cov-2 detection kits

Development of chimeric protein as a multivalent vaccine for human Kinetoplastid infections: Chagas disease and leishmaniasis

Authors: Marianna de Carvalho Clímaco, Luiza Almeida de Figueiredo, Rayane Cristina Lucas, Guilherme Rafael Gomide Pinheiro, Luísa Mourão Dias Magalhães, Ana Laura Grossi de Oliveira, Raquel Martins Almeida, Fernando Sérgio Barbosa, Daniella Castanheira Bartholomeu, Lilian Lacerda Bueno, Tiago Antonio Mendes, Bin Zhan, Kathryn Marie Jones, Peter Hotez, Maria Elena Bottazzi, Fabrício Marcus Silva Oliveira, Ricardo Toshio Fujiwara

Journal: Vaccine

PubMed ID: 37479612

Doi: 10.1016/j.vaccine.2023.07.020

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Integrated analysis and validation of TRIM23/p53 signaling pathway in hepatic stellate cells ferroptosis and liver fibrosis

Authors: Jie Chen, Rui Zhang, Feng Li, Shengli Lin, Jian Wang

Journal: Dig Liver Dis

PubMed ID: 37495427

Doi: 10.1016/j.dld.2023.07.010

Products & Services: Molecular Biology Reagents

Tetracycline-modifying enzyme SmTetX from Stenotrophomonas maltophilia

Authors: Martin Malý, Petr Kolenko, Jan Stránský, Leona Švecová, Jarmila Dušková, Tomáš Koval', Tereza Skálová, Mária Trundová, Kristýna Adámková, Jiří Černý, Paulína Božíková, Jan Dohnálek

Journal: Acta Crystallogr F Struct Biol Commun

PubMed ID: 37405486

Doi: 10.1107/S2053230X23005381

Products & Services: Proteins, Expression, Isolation and Analysis

PSW1, an LRR receptor kinase, regulates pod size in peanut

Authors: Kunkun Zhao, Long Wang, Ding Qiu, Zenghui Cao, Kuopeng Wang, Zhan Li, Xiaoxuan Wang, Jinzhi Wang, Qian Ma, Di Cao, Yinyao Qi, Kai Zhao, Fangping Gong, Zhongfeng Li, Rui Ren, Xingli Ma, Xingguo Zhang, Feng Yu, Dongmei Yin

Journal: Plant Biotechnol J

PubMed ID: 37431286

Doi: 10.1111/pbi.14117

Products & Services: Proteins, Expression, Isolation and Analysis

Aflatoxin B1 Exacerbates Genomic Instability and Apoptosis in the BTBR Autism Mouse Model via Dysregulating DNA Repair Pathway

Authors: Ali A Alshamrani, Mohammad Y Alwetaid, Mohammed A Al-Hamamah, Mohamed S M Attia, Sheikh F Ahmad, Majed A Algonaiah, Ahmed Nadeem, Mushtaq A Ansari, Saleh A Bakheet, Sabry M Attia

Journal: Toxics

PubMed ID: 37505601

Doi: 10.3390/toxics11070636

Products & Services: Proteins, Expression, Isolation and Analysis

Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice

Authors: Liming Yu, Lin Xu, Haiyan Chu, Jun Peng, Anastasia Sacharidou, Hsi-Hsien Hsieh, Ada Weinstock, Sohaib Khan, Liqian Ma, José Gabriel Barcia Durán, Jeffrey McDonald, Erik R Nelson, Sunghee Park, Donald P McDonnell, Kathryn J Moore, Lily Jun-Shen Huang, Edward A Fisher, Chieko Mineo, Linzhang Huang, Philip W Shaul

Journal: Nat Commun

PubMed ID: 37491347

Doi: 10.1038/s41467-023-39586-z

Products & Services: Proteins, Expression, Isolation and Analysis

gene knockdown induces insect cell lines death and level increases of intracellular calcium ions

Authors: Jiqiang Song, Yanping Yu, Zhichao Yan, Shan Xiao, Xianxin Zhao, Fang Wang, Qi Fang, Gongyin Ye

Journal: Front Physiol

PubMed ID: 37485065

Doi: 10.3389/fphys.2023.1217954

Products & Services: Proteins, Expression, Isolation and Analysis

CD38-Specific CAR Integrated into CD38 Locus Driven by Different Promoters Causes Distinct Antitumor Activities of T and NK Cells

Authors: Chan Liao, Yajie Wang, Yanjie Huang, Yanting Duan, Yan Liang, Jiangqing Chen, Jie Jiang, Kai Shang, Chun Zhou, Ying Gu, Nan Liu, Xun Zeng, Xiaofei Gao, Yongmin Tang, Jie Sun

Journal: Adv Sci (Weinh)

PubMed ID: 37485647

Doi: 10.1002/advs.202207394

Products & Services: Proteins, Expression, Isolation and Analysis

The Effect of Long-Term Passage on Porcine SMCs' Function and the Improvement of TGF-β1 on Porcine SMCs' Secretory Function in Late Passage

Authors: Yan-Yan Zheng, Ze-Nan Hu, Zheng Liu, Yi-Chen Jiang, Ren-Peng Guo, Shi-Jie Ding, Guang-Hong Zhou

Journal: Foods

PubMed ID: 37509774

Doi: 10.3390/foods12142682

Products & Services: Molecular Biology Reagents

Creation of a Peptide Antagonist of the GFRAL-RET Receptor Complex for the Treatment of GDF15-Induced Malaise

Authors: Tito Borner, Ian C Tinsley, Brandon T Milliken, Sarah A Doebley, Nicholas R Najjar, Deborah J Kerwood, Bart C De Jonghe, Matthew R Hayes, Robert P Doyle

Journal: J Med Chem

PubMed ID: 37506293

Doi: 10.1021/acs.jmedchem.3c00667

Products & Services: Molecular Biology Reagents

Hierarchical design of pseudosymmetric protein nanoparticles

Authors: Quinton M Dowling, Young-Jun Park, Neil Gerstenmaier, Erin C Yang, Adam Wargacki, Yang Hsia, Chelsea N Fries, Rashmi Ravichandran, Carl Walkey, Anika Burrell, David Veesler, David Baker, Neil P King

Journal: Res Sq

PubMed ID: 37503272

Doi: 10.21203/rs.3.rs-3074553/v1

Products & Services: Molecular Biology Reagents

Structural and Kinetic Characterization of the SpeG Spermidine/Spermine -acetyltransferase from Methicillin-Resistant USA300

Authors: Sofiya Tsimbalyuk, Aleksander Shornikov, Parul Srivastava, Van Thi Bich Le, Imani Warren, Yogesh B Khandokar, Misty L Kuhn, Jade K Forwood

Journal: Cells

PubMed ID: 37508494

Doi: 10.3390/cells12141829

Products & Services: Recombinant Antibody Expression

Mapping of corticotropin-releasing factor, receptors, and binding protein mRNA in the chicken telencephalon throughout development

Authors: Alek H Metwalli, Alessandra Pross, Ester Desfilis, Antonio Abellán, Loreta Medina

Journal: J Comp Neurol

PubMed ID: 37393534

Doi: 10.1002/cne.25517

Products & Services: PCR Cloning and Subcloning

Polyphenol Oxidase Products Are Priming Agents for LPMO Peroxygenase Activity

Authors: Caio de Oliveira Gorgulho Silva, Marlene Vuillemin, Mirjam A Kabel, Willem J H van Berkel, Anne S Meyer, Jane W Agger

Journal: ChemSusChem

PubMed ID: 37278305

Doi: 10.1002/cssc.202300559

Products & Services: Proteins, Expression, Isolation and Analysis

Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry

Authors: Susan A Leonhardt, Michael D Purdy, Jonathan R Grover, Ziwei Yang, Sandra Poulos, William E McIntire, Elizabeth A Tatham, Satchal K Erramilli, Kamil Nosol, Kin Kui Lai, Shilei Ding, Maolin Lu, Pradeep D Uchil, Andrés Finzi, Alan Rein, Anthony A Kossiakoff, Walther Mothes, Mark Yeager

Journal: Nat Commun

PubMed ID: 37474505

Doi: 10.1038/s41467-023-39262-2

Products & Services: Gene Synthesis

Biomimetic Mineralized CRISPR/Cas RNA Nanoparticles forEfficient Tumor-Specific Multiplex Gene Editing

Authors: Yan Liang , Jingge Zhang , Chenlu Xu , Jinjin Wang , Wenshuai Han , Jiali Yang , Sixuan Wu , Jingyi An , Junjie Liu , Zhenzhong Zhang , Jinjin Shi , Kaixiang Zhang

Journal: ACS Nano .

PubMed ID: 37481734

Doi: 10.1021/acsnano.3c04116

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Nanoengineered mesenchymal stem cell therapy for pulmonary fibrosis in young and aged mice

Authors: Meng-Meng Han , Xing-Yue He , Ling Tang , Liang Qi , Ming-Yuan Yang , Yi Wang , Lei Xing , Jee-Heon Jeong , Hu-Lin Jiang

Journal: Sci Adv .

PubMed ID: 37467328

Doi: 10.1126/sciadv.adg5358

Products & Services: Recombinant Proteins

Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses

Authors: Xiuyuan Ou , Ge Xu , Pei Li , Yan Liu , Fuwen Zan , Pan Liu , Jiaxin Hu , Xing Lu , Siwen Dong , Yao Zhou , Zhixia Mu , Zhiqiang Wu , Jianwei Wang , Qi Jin , Pinghuang Liu , Jian Lu , Xiangxi Wang , Zhaohui Qian

Journal: Cell Discov .

PubMed ID: 37507385

Doi: 10.1038/s41421-023-00581-9

Products & Services: Gene Synthesis

A neural cell adhesion molecule from oyster Crassostrea gigas: Molecular identification and immune functional characterization

Authors: Xue Qiao, Conghui Liu, Weilin Wang, Chuanyan Yang, Meijia Li, Qilin Yi, Ning Kong, Limei Qiu, Xiyang Liu, Lingling Wang, Linsheng Song

Journal: Int J Biol Macromol

PubMed ID: 37429340

Doi: 10.1016/j.ijbiomac.2023.125756

Products & Services: Proteins, Expression, Isolation and Analysis

Engineering the HK97 virus-like particle as a nanoplatform for biotechnology applications

Authors: Michael D Woods, Matthew Cali, Bubacarr Ceesay, Shandis Fancher, Gaini Ibrasheva, Suefian Kandeel, Manon Nassar, Ali Azghani, Brent Bill, Dustin P Patterson

Journal: J Mater Chem B

PubMed ID: 37345352

Doi: 10.1039/d3tb00318c

Products & Services: Proteins, Expression, Isolation and Analysis

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice

Authors: Nana Li, Junjie Yu, Meiyang Zhou, Fanyi Qiu, Xiao Wang, Zhengpin Wang

Journal: Biochem Biophys Res Commun

PubMed ID: 37451217

Doi: 10.1016/j.bbrc.2023.07.013

Products & Services: Proteins, Expression, Isolation and Analysis

Structural and biochemical characterization of Schlafen11 N-terminal domain

Authors: Pengjiao Hou, Wei Hao, Bo Qin, Mengyun Li, Rong Zhao, Sheng Cui

Journal: Nucleic Acids Res

PubMed ID: 37293979

Doi: 10.1093/nar/gkad509

Products & Services: Gene Synthesis

An Immunoinformatics-Based Study of Mycobacterium tuberculosis Region of Difference-2 Uncharacterized Protein (Rv1987) as a Potential Subunit Vaccine Candidate for Preliminary Ex Vivo Analysis

Authors: Aregitu Mekuriaw Arega, Ajit Kumar Dhal, Kali Prasad Pattanaik, Sasmita Nayak, Rajani Kanta Mahapatra

Journal: Appl Biochem Biotechnol

PubMed ID: 37498378

Doi: 10.1007/s12010-023-04658-9

Products & Services: Gene Synthesis

A Biosafety Study of Human Umbilical Cord Blood Mononuclear Cells Transduced with Adenoviral Vector Carrying Human Vascular Endothelial Growth Factor cDNA In Vitro

Authors: Ilnur I Salafutdinov , Dilara Z Gatina , Maria I Markelova , Ekaterina E Garanina , Sergey Yu Malanin , Ilnaz M Gazizov , Andrei A Izmailov , Albert A Rizvanov , Rustem R Islamov , András Palotás , Zufar Z Safiullov

Journal: Biomedicines .

PubMed ID: 37509661

Doi: 10.3390/biomedicines11072020

Products & Services: Catalog Antibody

Actions of a Novel Bacterial Topoisomerase Inhibitor against Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks

Authors: Soziema E Dauda, Jessica A Collins, Jo Ann W Byl, Yanran Lu, Jack C Yalowich, Mark J Mitton-Fry, Neil Osheroff

Journal: Int J Mol Sci

PubMed ID: 37569485

Doi: 10.3390/ijms241512107

Products & Services: Proteins, Expression, Isolation and Analysis

Accurate identification and discrimination of serovar Gallinarum biovars Gallinarum and Pullorum by a multiplex PCR based on the new genes of and

Authors: Li Song, Ruimeng Tan, Dan Xiong, Xinan Jiao, Zhiming Pan

Journal: Front Vet Sci

PubMed ID: 37476820

Doi: 10.3389/fvets.2023.1220118

Products & Services: Proteins, Expression, Isolation and Analysis

A mass spectrometry assay for detection of endogenous and lentiviral engineered hemoglobin in cultured cells and sickle cell disease mice

Authors: Xuejun Wang, William M McKillop, Theresa A Dlugi, Mary L Faber, Juliana Alvarez-Argote, Christopher B Chambers, Andrew Wilber, Jeffrey A Medin

Journal: J Gene Med

PubMed ID: 37455676

Doi: 10.1002/jgm.3567

Products & Services: Peptide Synthesis

Kinetic and Structural Characterization of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors

Authors: Kayla Glockzin, Kathleen M Meneely, Ryan Hughes, Sean W Maatouk, Grace E Piña, Kajitha Suthagar, Keith Clinch, Joshua N Buckler, Audrey L Lamb, Peter C Tyler, Thomas D Meek, Ardala Katzfuss

Journal: Biochemistry

PubMed ID: 37418678

Doi: 10.1021/acs.biochem.3c00116

Products & Services: Proteins, Expression, Isolation and Analysis

Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity

Authors: Ian N Boys, Alex G Johnson, Meghan R Quinlan, Philip J Kranzusch, Nels C Elde

Journal: Cell Rep

PubMed ID: 37494187

Doi: 10.1016/j.celrep.2023.112878

Products & Services: Molecular Biology Reagents

Computationally Designed Small Molecules Disassemble Both Soluble Oligomers and Protofibrils of Amyloid β-Protein Responsible for Alzheimer's Disease

Authors: Yingying Jin, Matthew A Downey, Ambuj Singh, Steven K Buratto, Michael T Bowers

Journal: ACS Chem Neurosci

PubMed ID: 37442126

Doi: 10.1021/acschemneuro.3c00266

Products & Services: Proteins, Expression, Isolation and Analysis

Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues

Authors: Yorick Post, Archana Dilip, Liqin Xie, Asmiti Sura, Nicholas Suen, Jay Ye, Devin Mutha, Angela T Liu, Huy Nguyen, Elizabeth Whisler, Darshini Shah, Shalaka Deshmukh, Navrose Dhaliwal, Ben Bauer, Eskedar Nigatu, Anh Diep, Tom Lopez, Tristan W Fowler, Sung-Jin Lee, Chenggang Lu, Wen-Chen Yeh, Hui Chen, Yang Li

Journal: Cell Chem Biol

PubMed ID: 37413985

Doi: 10.1016/j.chembiol.2023.06.006

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Role and neural regulation of clock genes in the rat pineal gland: Clock modulates amplitude of rhythmic expression of Aanat encoding the melatonin-producing enzyme

Authors: Aurea S Blancas-Velazquez, Tenna Bering, Signe Bille, Martin F Rath

Journal: J Pineal Res

PubMed ID: 37349875

Doi: 10.1111/jpi.12893

Products & Services: Proteins, Expression, Isolation and Analysis

Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor

Authors: Wan Ni Chia, Chee Wah Tan, Aaron Wai Kit Tan, Barnaby Young, Tyler N Starr, Ester Lopez, Guntur Fibriansah, Jennifer Barr, Samuel Cheng, Aileen Ying-Yan Yeoh, Wee Chee Yap, Beng Lee Lim, Thiam-Seng Ng, Wan Rong Sia, Feng Zhu, Shiwei Chen, Jinyan Zhang, Madeline Sheng Si Kwek, Allison J Greaney, Mark Chen, Gough G Au, Prasad N Paradkar, Malik Peiris, Amy W Chung, Jesse D Bloom, David Lye, Sheemei Lok, Lin-Fa Wang

Journal: Sci Adv

PubMed ID: 37494438

Doi: 10.1126/sciadv.ade3470

Products & Services: Proteins, Expression, Isolation and Analysis

Breakthrough SARS-CoV-2 Omicron Variant in Individuals Primed with Heterologous Vaccines Enhances Inhibition Performance of Neutralizing Antibody to BA2 Parental Lineage

Authors: Jidapa Szekely, Piyawut Swangphon, Natthaphon Nanakorn, Panuttha Chaimuti, Teerapat Nualnoi, Paweena Wongwitwichot, Namchoke Somapa, Denpong Somapa, Theerakamol Pengsakul

Journal: Vaccines (Basel)

PubMed ID: 37515045

Doi: 10.3390/vaccines11071230

Products & Services: Molecular Biology Reagents

Development of quantitative multiplex RT-qPCR one step assay for detection of hepatitis delta virus

Authors: Jackson Alves da Silva Queiroz, Tárcio Peixoto Roca, Rutilene Barbosa Souza, Luiz Fellype Alves de Souza, Ana Maísa Passos-Silva, André Luiz Ferreira da Silva, Eugênia de Castro E Silva, Lourdes Maria Pinheiro Borzacov, Rita de Cássia Pontello Rampazzo, Soraya Dos Santos Pereira, Thor Oliveira Dantas, Janaína Mazaro, Lívia Melo Villar, Juan Miguel Villalobos Salcedo, Daniel Archimedes da Matta, Deusilene Vieira

Journal: Sci Rep

PubMed ID: 37495613

Doi: 10.1038/s41598-023-37756-z

Products & Services: Molecular Biology Reagents

Absolute Quantification of Photoreceptor Outer Segment Proteins

Authors: Nikolai P Skiba, Tylor R Lewis, William J Spencer, Carson M Castillo, Andrej Shevchenko, Vadim Y Arshavsky

Journal: J Proteome Res

PubMed ID: 37493966

Doi: 10.1021/acs.jproteome.3c00267

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Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity

Authors: Benedikt Goretzki, Christoph Wiedemann, Brett A McCray, Stefan L Schäfer, Jasmin Jansen, Frederike Tebbe, Sarah-Ana Mitrovic, Julia Nöth, Ainara Claveras Cabezudo, Jack K Donohue, Cy M Jeffries, Wieland Steinchen, Florian Stengel, Charlotte J Sumner, Gerhard Hummer, Ute A Hellmich

Journal: Nat Commun

PubMed ID: 37443299

Doi: 10.1038/s41467-023-39808-4

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Structural basis of CXC chemokine receptor 1 ligand binding and activation

Authors: Naito Ishimoto, Jae-Hyun Park, Kouki Kawakami, Michiko Tajiri, Kenji Mizutani, Satoko Akashi, Jeremy R H Tame, Asuka Inoue, Sam-Yong Park

Journal: Nat Commun

PubMed ID: 37433790

Doi: 10.1038/s41467-023-39799-2

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Spatially-Encoding Hydrogels With DNA to Control Cell Signaling

Authors: Namrata Ramani, C Adrian Figg, Alex J Anderson, Peter H Winegar, EunBi Oh, Sasha B Ebrahimi, Devleena Samanta, Chad A Mirkin

Journal: Adv Mater

PubMed ID: 37221642

Doi: 10.1002/adma.202301086

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Tepsin binds LC3B to promote ATG9A export and delivery at the cell periphery

Authors: Natalie S Wallace, John E Gadbery, Cameron I Cohen, Amy K Kendall, Lauren P Jackson

Journal: biorxiv

PubMed ID: 37502979

Doi: 10.1101/2023.07.18.549521

Products & Services: Proteins, Expression, Isolation and Analysis

Non-canonical function of folate/folate receptor 1 during neural tube formation

Authors: Olga A Balashova, Alexios A Panoutsopoulos, Olesya Visina, Jacob Selhub, Paul S Knoepfler, Laura N Borodinsky

Journal: biorxiv

PubMed ID: 37503108

Doi: 10.1101/2023.07.19.549718

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Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis

Authors: Yi Zhou, Guofei Cui, Hongwei Xu, Joanne Chun, Doris Yang, Zheng Zhang, Lihui Yang, Jingxiao Wang, Meijuan Wan, Diego F Calvisi, Shumei Lin, Xin Chen, Haichuan Wang

Journal: Cell Death Dis

PubMed ID: 37500626

Doi: 10.1038/s41419-023-05958-y

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Targeting the Spike Receptor Binding Domain Class V Cryptic Epitope by an Antibody with Pan-Sarbecovirus Activity

Authors: Jaime L Jensen, Rajeshwer S Sankhala, Vincent Dussupt, Hongjun Bai, Agnes Hajduczki, Kerri G Lal, William C Chang, Elizabeth J Martinez, Caroline E Peterson, Emily S Golub, Phyllis A Rees, Letzibeth Mendez-Rivera, Michelle Zemil, Erin Kavusak, Sandra V Mayer, Lindsay Wieczorek, Shruthi Kannan, Benjamin J Doranz, Edgar Davidson, Eun Sung Yang, Yi Zhang, Man Chen, Misook Choe, Lingshu Wang, Gregory D Gromowski, Richard A Koup, Nelson L Michael, Victoria R Polonis, Morgane Rolland, Kayvon Modjarrad, Shelly J Krebs, M Gordon Joyce

Journal: J Virol

PubMed ID: 37395646

Doi: 10.1128/jvi.01596-22

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Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes

Authors: Shaun K Bremner, Rebecca Berends, Alexandra Kaupisch, Jennifer Roccisana, Calum Sutherland, Nia J Bryant, Gwyn W Gould

Journal: PeerJ

PubMed ID: 37520260

Doi: 10.7717/peerj.15630

Products & Services: Proteins, Expression, Isolation and Analysis

A natural gene drive system confers reproductive isolation in rice

Authors: Chaolong Wang, Jian Wang, Jiayu Lu, Yehui Xiong, Zhigang Zhao, Xiaowen Yu, Xiaoming Zheng, Jing Li, Qibing Lin, Yulong Ren, Yang Hu, Xiaodong He, Chao Li, Yonglun Zeng, Rong Miao, Mali Guo, Bosen Zhang, Ying Zhu, Yunhui Zhang, Weijie Tang, Yunlong Wang, Benyuan Hao, Qiming Wang, Siqi Cheng, Xiaojuan He, Bowen Yao, Junwen Gao, Xufei Zhu, Hao Yu, Yong Wang, Yan Sun, Chunlei Zhou, Hui Dong, Xiaoding Ma, Xiuping Guo, Xi Liu, Yunlu Tian, Shijia Liu, Chunming Wang, Zhijun Cheng, Ling Jiang, Jiawu Zhou, Huishan Guo, Liwen Jiang, Dayun Tao, Jijie Chai, Wei Zhang, Haiyang Wang, Chuanyin Wu, Jianmin Wan

Journal: Cell

PubMed ID: 37499659

Doi: 10.1016/j.cell.2023.06.023

Products & Services: Proteins, Expression, Isolation and Analysis

Histone deacetylase III interactions with BK polyomavirus large tumor antigen may affect protein stability

Authors: Yueh-Han Hsu, Chun-Nun Chao, Hsin-Yi Huang, Pei-Wen Zhao, Pang-Hung Hsu, Cheng-Huang Shen, San-Yuan Chen, Chiung-Yao Fang

Journal: Virol J

PubMed ID: 37464367

Doi: 10.1186/s12985-023-02128-6

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TP5: A Novel Therapeutic Approach Targeting Aberrant and Hyperactive CDK5/p25 for the Treatment of Colorectal Carcinoma

Authors: Niranjana Amin, Herui Wang, Qi Song, Manju Bhaskar, Sharda Prasad Yadav, Mark R Gilbert, Harish Pant, Emeline Tabouret, Zhengping Zhuang

Journal: Int J Mol Sci

PubMed ID: 37511490

Doi: 10.3390/ijms241411733

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Class I histone deacetylase complex: Structure and functional correlates

Authors: Xiao Wang, Yannan Wang, Simiao Liu, Yi Zhang, Ke Xu, Liting Ji, Roger D Kornberg, Heqiao Zhang

Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PubMed ID: 37459529

Doi: 10.1073/pnas.2307598120

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Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS–STING pathway

Authors: Jing An , Chuan-Ping Zhang , Hou-Yuan Qiu , Hong-Xia Zhang , Qiu-Bing Chen , Yu-Ming Zhang , Xin-Lin Lei , Cai-Xiang Zhang , Hao Yin , Ying Zhang

Journal: Nat Biomed Eng .

PubMed ID: 37500747

Doi: 10.1038/s41551-023-01073-7

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The combination of osimertinib with Raf inhibitor overcomes osimertinib resistance induced by KRAS amplification in EGFR-mutated lung cancer cells

Authors: Tae-Gul Lee, Hye-Min Kang, Seo Yun Kim, Hye-Ryoun Kim, Cheol Hyeon Kim

Journal: Exp Cell Res

PubMed ID: 37442265

Doi: 10.1016/j.yexcr.2023.113722

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Combined Inhibition of the TGF-β1/Smad Pathway by and to Reduce Inflammation and Fibrosis in Primary Sclerosing Cholangitis

Authors: Yu Shen, Baorong Jiang, Chenchen Zhang, Qian Wu, Lei Li, Ping Jiang

Journal: Int J Mol Sci

PubMed ID: 37446187

Doi: 10.3390/ijms241311010

Products & Services: Proteins, Expression, Isolation and Analysis

Viral manipulation of cell polarity signalling

Authors: Airah Javorsky, Patrick O Humbert, Marc Kvansakul

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 37437846

Doi: 10.1016/j.bbamcr.2023.119536

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Macrophage infectivity potentiator protein, a peptidyl prolyl cis-trans isomerase, essential for Coxiella burnetii growth and pathogenesis

Authors: Aleksandra W Debowski, Nicole M Bzdyl, David R Thomas, Nichollas E Scott, Christopher H Jenkins, Jua Iwasaki, Emily A Kibble, Chen Ai Khoo, Nicolas J Scheuplein, Pamela M Seibel, Theresa Lohr, Georgie Metters, Charles S Bond, Isobel H Norville, Keith A Stubbs, Nicholas J Harmer, Ulrike Holzgrabe, Hayley J Newton, Mitali Sarkar-Tyson

Journal: PLoS Pathog

PubMed ID: 37399210

Doi: 10.1371/journal.ppat.1011491

Products & Services: Proteins, Expression, Isolation and Analysis

Investigating the aggregation perspective of Dengue virus proteome

Authors: Shivani Krishna Kapuganti, Kumar Udit Saumya, Deepanshu Verma, Rajanish Giri

Journal: Virology

PubMed ID: 37473502

Doi: 10.1016/j.virol.2023.07.010

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Notch Intracellular Domains form Transcriptionally Active Heterodimeric Complexes on Sequence-paired Sites

Authors: Tana R Gazdik, Jacob J Crow, Tyler Lawton, Chloe J Munroe, Hannah Theriault, Travis M Wood, Allan R Albig

Journal: Res Sq

PubMed ID: 37546896

Doi: 10.21203/rs.3.rs-3147210/v1

Products & Services: Proteins, Expression, Isolation and Analysis

Pathogenic CANVAS (AAGGG) repeats stall DNA replication due to the formation of alternative DNA structures

Authors: Julia A Hisey, Elina A Radchenko, Silvia Ceschi, Anastasia Rastokina, Nicholas H Mandel, Ryan J McGinty, Gabriel Matos-Rodrigues, Alfredo Hernandez, André Nussenzweig, Sergei M Mirkin

Journal: biorxiv

PubMed ID: 37546920

Doi: 10.1101/2023.07.25.550509

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Prokaryotic Gabija complex senses and executes nucleotide depletion and DNA cleavage for antiviral defense

Authors: Rui Cheng , Fengtao Huang , Xueling Lu , Yan Yan , Bingbing Yu , Xionglue Wang , Bin Zhu

Journal: Cell Host Microbe .

PubMed ID: 37480847

Doi: 10.1016/j.chom.2023.06.014

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Targeting CXCR4-expressing Cancer Cells with Avidin-poly (lactic-co-glycolic acid) Nanoparticle Surface Modified with Biotinylated DV1 Peptide

Authors: Shiba Ansari, Madeeha Mudassir, B Vijayalekshmi, Parthaprasad Chattopadhyay

Journal: Int J Appl Basic Med Res

PubMed ID: 37614837

Doi: 10.4103/ijabmr.ijabmr_58_23

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Mesothelin-targeting T cell receptor fusion construct cell therapy in refractory solid tumors: phase 1/2 trial interim results

Authors: Raffit Hassan, Marcus Butler, Roisin E O'Cearbhaill, David Y Oh, Melissa Johnson, Kevin Zikaras, Munisha Smalley, Michael Ross, Janos L Tanyi, Azam Ghafoor, Nirali N Shah, Babak Saboury, Liang Cao, Alfonso Quintás-Cardama, David Hong

Journal: Nat Med

PubMed ID: 37501016

Doi: 10.1038/s41591-023-02452-y

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Monitoring SARS-CoV-2 variants in wastewater of Dhaka City, Bangladesh: approach to complement public health surveillance systems

Authors: Rehnuma Haque, Mohammad Enayet Hossain, Mojnu Miah, Mahbubur Rahman, Nuhu Amin, Ziaur Rahman, Md Shariful Islam, Mohammed Ziaur Rahman

Journal: Hum Genomics

PubMed ID: 37420264

Doi: 10.1186/s40246-023-00505-4

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Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins

Authors: Ashley P Viera Ortiz, Gregory Cajka, Olamide A Olatunji, Bailey Mikytuck, Ophir Shalem, Edward B Lee

Journal: Brain

PubMed ID: 36516294

Doi: 10.1093/brain/awac479

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Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma

Authors: Shiqun Wang , Wei Yan, Lingkai Kong , Shuguang Zuo , Jingyi Wu, Chunxiao Zhu , Huaping Huang , Bohao He, Jie Dong, Jiwu Wei

Journal: Nat Commun .

PubMed ID: 37474548

Doi: 10.1038/s41467-023-39683-z

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Enhanced Carotenoid Production in Chlamydomonas reinhardtii via Overexpression of Endogenous and Exogenous Beta-Carotene Ketolase (BKT) Genes

Authors: Yuanhao Chen , Hong Du , Honghao Liang , Ting Hong , Tangcheng Li

Journal: Int J Mol Sci .

PubMed ID: 37511141

Doi: 1422-0067/24/14/11382

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Perdeuterated GbpA Enables Neutron Scattering Experiments of a Lytic Polysaccharide Monooxygenase

Authors: H V Sørensen, Mateu Montserrat-Canals, Jennifer S M Loose, S Zoë Fisher, Martine Moulin, Matthew P Blakeley, Gabriele Cordara, Kaare Bjerregaard-Andersen, Ute Krengel

Journal: ACS Omega

PubMed ID: 37599915

Doi: 10.1021/acsomega.3c02168

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Immunogenicity and safety of inactivated SARS-CoV-2 vaccine in haemodialysis patients: a prospective cohort study

Authors: Metalia Puspitasari, Prenali D Sattwika, Dzerlina S Rahari, Wynne Wijaya, Auliana R P Hidayat, Nyoman Kertia, Bambang Purwanto, Jarir At Thobari

Journal: Sci Rep

PubMed ID: 37463975

Doi: 10.1038/s41598-023-38628-2

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Interspersed expression of CUP-SHAPED COTYLEDON2 and REDUCED COMPLEXITY shapes Cardamine hirsuta complex leaf form

Authors: Neha Bhatia, David Wilson-Sánchez, Sören Strauss, Francesco Vuolo, Bjorn Pieper, Ziliang Hu, Léa Rambaud-Lavigne, Miltos Tsiantis

Journal: Curr Biol

PubMed ID: 37453425

Doi: 10.1016/j.cub.2023.06.037

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A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism

Authors: Yingjia Yao, Yunhan Zhang, Zexu Li, Zhisong Chen, Xiaofeng Wang, Zihan Li, Li Yu, Xiaolong Cheng, Wei Li, Wen-Jie Jiang, Hua-Jun Wu, Zezhong Feng, Jinfu Sun, Teng Fei

Journal: Biochem Biophys Res Commun

PubMed ID: 37467664

Doi: 10.1016/j.bbrc.2023.07.018

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Purification and characterization of human glycerol 3-phosphate dehydrogenases (mitochondrial and cytosolic) by NAD/NADH redox method

Authors: Superior Syngkli, Bidyadhar Das

Journal: Biochimie

PubMed ID: 37481063

Doi: 10.1016/j.biochi.2023.07.015

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N6-Methyladenosine Promotes Translation of VEGFA to Accelerate Angiogenesis in Lung Cancer

Authors: Haisheng Zhang, Jiawang Zhou, Jiexin Li, Zhaotong Wang, Zhuojia Chen, Ziyan Lv, Lichen Ge, Guoyou Xie, Guoming Deng, Yalan Rui, Hongbing Huang, Likun Chen, Hongsheng Wang

Journal: Cancer Res

PubMed ID: 37103476

Doi: 10.1158/0008-5472.CAN-22-2449

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Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1

Authors: Eva-Maria Thüring, Christian Hartmann, Janesha C Maddumage, Airah Javorsky, Birgitta E Michels, Volker Gerke, Lawrence Banks, Patrick O Humbert, Marc Kvansakul, Klaus Ebnet

Journal: Commun Biol

PubMed ID: 37430142

Doi: 10.1038/s42003-023-05088-3

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Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins

Authors: Haolan Wang , Ming Guo , Hudie Wei , Yongheng Chen

Journal: Comput Struct Biotechnol J .

PubMed ID: 37560128

Doi: 10.1016/j.csbj.2023.07.017

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The combined action of the intracellular regions regulates FGFR2 kinase activity

Authors: Chi-Chuan Lin , Lukasz Wieteska , Guillaume Poncet-Montange , Kin Man Suen , Stefan T Arold , Zamal Ahmed , John E Ladbury

Journal: Commun Biol .

PubMed ID: 37452126

Doi: 10.1038/s42003-023-05112-6

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Development of miniature base editors using engineered IscB nickase

Authors: Dingyi Han , Qingquan Xiao , Yifan Wang , Hainan Zhang , Xue Dong , Guoling Li , Xiangfeng Kong , Shihao Wang , Jinhui Song , Weihong Zhang , Jingxing Zhou , Lanting Bi , Yuan Yuan , Linyu Shi , Na Zhong , Hui Yang , Yingsi Zhou

Journal: Nat Methods .

PubMed ID: 37231266

Doi: 10.1038/s41592-023-01898-9

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Manganese-based microcrystals equipped with Ythdf1-targeted biomimeticnanovaccines for reinforced dendritic cell spatiotemporal orchestration

Authors: Feng Liu , Lulu Tan, Zheng Dai , Yang Wang , Lei Huang , Yang Zhang , Qian Cheng , Xin Li , Miao-Deng Liu, Lin Wang, Zheng Wang

Journal: Nano Today

Doi: 10.1016/j.nantod.2023.102112

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Biomimetic Nanofibrillar Hydrogel with Cell-Adaptable Network for Enhancing Cellular Mechanotransduction, Metabolic Energetics, and Bone Regeneration

Authors: Xian Xie ， Zhuo Li , Xuefeng Yang , Boguang Yang , Zhixian Zong , Xuemei Wang , Liting Duan , Sien Lin , Gang Li , Liming Bian

Journal: J Am Chem Soc

PubMed ID: 37428960

Doi: 10.1021/jacs.3c02210

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Construction and characterization of a novel miniaturized filamentous phagemid for targeted mammalian gene transfer

Authors: Shirley Wong, Salma Jimenez, Roderick A Slavcev

Journal: Microb Cell Fact

PubMed ID: 37430278

Doi: 10.1186/s12934-023-02135-w

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Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants

Authors: Ebene R Haycroft, Samantha K Davis, Pradhipa Ramanathan, Ester Lopez, Ruth A Purcell, Li Lynn Tan, Phillip Pymm, Bruce D Wines, P Mark Hogarth, Adam K Wheatley, Jennifer A Juno, Samuel J Redmond, Nicholas A Gherardin, Dale I Godfrey, Wai-Hong Tham, Kevin John Selva, Stephen J Kent, Amy W Chung

Journal: Med Microbiol Immunol

PubMed ID: 37477828

Doi: 10.1007/s00430-023-00773-w

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Effectors of the Type VI Secretion System Have the Potential to Be Modified into Antimicrobial Peptides

Authors: Wenjia Lu, Hao Lu, Chenchen Wang, Gaoyan Wang, Wenqi Dong, Chen Tan

Journal: Microbiol Spectr

PubMed ID: 37470717

Doi: 10.1128/spectrum.00308-23

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Fusion of Substrate-Binding Domains Enhances the Catalytic Capacity of Keratinases and Promotes Enzymatic Conversion of Feather Waste

Authors: Xiaomei Ji, Zheng Peng, Jie Song, Guoqiang Zhang, Juan Zhang

Journal: J Agric Food Chem

PubMed ID: 37462367

Doi: 10.1021/acs.jafc.3c03064

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Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G

Authors: Takahide Kouno, Satoshi Shibata, Megumi Shigematsu, Jaekyung Hyun, Tae Gyun Kim, Hiroshi Matsuo, Matthias Wolf

Journal: Nat Commun

PubMed ID: 37419875

Doi: 10.1038/s41467-023-39796-5

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An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles

Authors: Huanhuan Li, Yixi Wu, Minke Li, Lu Guo, Yaqi Gao, Quan Wang, Jihua Zhang, Zhaohua Lai, Xing Zhang, Lixin Zhu, Ping Lan, Zihe Rao, Yingfang Liu, Huanhuan Liang

Journal: Nat Struct Mol Biol

PubMed ID: 37488357

Doi: 10.1038/s41594-023-01043-2

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Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity

Authors: Jay C Groppe, Guorong Lu, Mary R Tandang-Silvas, Anupama Pathi, Shruti Konda, Jingfeng Wu, Viet Q Le, Andria L Culbert, Eileen M Shore, Kristi A Wharton, Frederick S Kaplan

Journal: Biomolecules

PubMed ID: 37509165

Doi: 10.3390/biom13071129

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Tumor Site-Specific Cleavage Improves the Antitumor Efficacy of Antibody-Drug Conjugates

Authors: Keyuan Xu, Jiani Han, Liu Yang, Li Cao, Shuang Li, Zhangyong Hong

Journal: Int J Mol Sci

PubMed ID: 37446189

Doi: 10.3390/ijms241311011

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Peptide/Nanoparticle Biointerfaces for Multistep Tandem Catalysis

Authors: Yuliana Perdomo, Joseph M Slocik, David M Phillips, Marc R Knecht