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The combination of osimertinib with Raf inhibitor overcomes osimertinib resistance induced by KRAS amplification in EGFR-mutated lung cancer cells

Authors: Tae-Gul Lee, Hye-Min Kang, Seo Yun Kim, Hye-Ryoun Kim, Cheol Hyeon Kim

Journal: Exp Cell Res

PubMed ID: 37442265

Doi: 10.1016/j.yexcr.2023.113722

Products & Services: Proteins, Expression, Isolation and Analysis

Combined Inhibition of the TGF-β1/Smad Pathway by and to Reduce Inflammation and Fibrosis in Primary Sclerosing Cholangitis

Authors: Yu Shen, Baorong Jiang, Chenchen Zhang, Qian Wu, Lei Li, Ping Jiang

Journal: Int J Mol Sci

PubMed ID: 37446187

Doi: 10.3390/ijms241311010

Products & Services: Proteins, Expression, Isolation and Analysis

Interspersed expression of CUP-SHAPED COTYLEDON2 and REDUCED COMPLEXITY shapes Cardamine hirsuta complex leaf form

Authors: Neha Bhatia, David Wilson-Sánchez, Sören Strauss, Francesco Vuolo, Bjorn Pieper, Ziliang Hu, Léa Rambaud-Lavigne, Miltos Tsiantis

Journal: Curr Biol

PubMed ID: 37453425

Doi: 10.1016/j.cub.2023.06.037

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A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism

Authors: Yingjia Yao, Yunhan Zhang, Zexu Li, Zhisong Chen, Xiaofeng Wang, Zihan Li, Li Yu, Xiaolong Cheng, Wei Li, Wen-Jie Jiang, Hua-Jun Wu, Zezhong Feng, Jinfu Sun, Teng Fei

Journal: Biochem Biophys Res Commun

PubMed ID: 37467664

Doi: 10.1016/j.bbrc.2023.07.018

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Purification and characterization of human glycerol 3-phosphate dehydrogenases (mitochondrial and cytosolic) by NAD/NADH redox method

Authors: Superior Syngkli, Bidyadhar Das

Journal: Biochimie

PubMed ID: 37481063

Doi: 10.1016/j.biochi.2023.07.015

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Investigating the aggregation perspective of Dengue virus proteome

Authors: Shivani Krishna Kapuganti, Kumar Udit Saumya, Deepanshu Verma, Rajanish Giri

Journal: Virology

PubMed ID: 37473502

Doi: 10.1016/j.virol.2023.07.010

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Notch Intracellular Domains form Transcriptionally Active Heterodimeric Complexes on Sequence-paired Sites

Authors: Tana R Gazdik, Jacob J Crow, Tyler Lawton, Chloe J Munroe, Hannah Theriault, Travis M Wood, Allan R Albig

Journal: Res Sq

PubMed ID: 37546896

Doi: 10.21203/rs.3.rs-3147210/v1

Products & Services: Proteins, Expression, Isolation and Analysis

Pathogenic CANVAS (AAGGG) repeats stall DNA replication due to the formation of alternative DNA structures

Authors: Julia A Hisey, Elina A Radchenko, Silvia Ceschi, Anastasia Rastokina, Nicholas H Mandel, Ryan J McGinty, Gabriel Matos-Rodrigues, Alfredo Hernandez, André Nussenzweig, Sergei M Mirkin

Journal: biorxiv

PubMed ID: 37546920

Doi: 10.1101/2023.07.25.550509

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Enhanced Carotenoid Production in Chlamydomonas reinhardtii via Overexpression of Endogenous and Exogenous Beta-Carotene Ketolase (BKT) Genes

Authors: Yuanhao Chen , Hong Du , Honghao Liang , Ting Hong , Tangcheng Li

Journal: Int J Mol Sci .

PubMed ID: 37511141

Doi: 1422-0067/24/14/11382

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Prokaryotic Gabija complex senses and executes nucleotide depletion and DNA cleavage for antiviral defense

Authors: Rui Cheng , Fengtao Huang , Xueling Lu , Yan Yan , Bingbing Yu , Xionglue Wang , Bin Zhu

Journal: Cell Host Microbe .

PubMed ID: 37480847

Doi: 10.1016/j.chom.2023.06.014

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Perdeuterated GbpA Enables Neutron Scattering Experiments of a Lytic Polysaccharide Monooxygenase

Authors: H V Sørensen, Mateu Montserrat-Canals, Jennifer S M Loose, S Zoë Fisher, Martine Moulin, Matthew P Blakeley, Gabriele Cordara, Kaare Bjerregaard-Andersen, Ute Krengel

Journal: ACS Omega

PubMed ID: 37599915

Doi: 10.1021/acsomega.3c02168

Products & Services: Proteins, Expression, Isolation and Analysis

Viral manipulation of cell polarity signalling

Authors: Airah Javorsky, Patrick O Humbert, Marc Kvansakul

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 37437846

Doi: 10.1016/j.bbamcr.2023.119536

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N6-Methyladenosine Promotes Translation of VEGFA to Accelerate Angiogenesis in Lung Cancer

Authors: Haisheng Zhang, Jiawang Zhou, Jiexin Li, Zhaotong Wang, Zhuojia Chen, Ziyan Lv, Lichen Ge, Guoyou Xie, Guoming Deng, Yalan Rui, Hongbing Huang, Likun Chen, Hongsheng Wang

Journal: Cancer Res

PubMed ID: 37103476

Doi: 10.1158/0008-5472.CAN-22-2449

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Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma

Authors: Shiqun Wang , Wei Yan, Lingkai Kong , Shuguang Zuo , Jingyi Wu, Chunxiao Zhu , Huaping Huang , Bohao He, Jie Dong, Jiwu Wei

Journal: Nat Commun .

PubMed ID: 37474548

Doi: 10.1038/s41467-023-39683-z

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Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins

Authors: Haolan Wang , Ming Guo , Hudie Wei , Yongheng Chen

Journal: Comput Struct Biotechnol J .

PubMed ID: 37560128

Doi: 10.1016/j.csbj.2023.07.017

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The combined action of the intracellular regions regulates FGFR2 kinase activity

Authors: Chi-Chuan Lin , Lukasz Wieteska , Guillaume Poncet-Montange , Kin Man Suen , Stefan T Arold , Zamal Ahmed , John E Ladbury

Journal: Commun Biol .

PubMed ID: 37452126

Doi: 10.1038/s42003-023-05112-6

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Development of miniature base editors using engineered IscB nickase

Authors: Dingyi Han , Qingquan Xiao , Yifan Wang , Hainan Zhang , Xue Dong , Guoling Li , Xiangfeng Kong , Shihao Wang , Jinhui Song , Weihong Zhang , Jingxing Zhou , Lanting Bi , Yuan Yuan , Linyu Shi , Na Zhong , Hui Yang , Yingsi Zhou

Journal: Nat Methods .

PubMed ID: 37231266

Doi: 10.1038/s41592-023-01898-9

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Manganese-based microcrystals equipped with Ythdf1-targeted biomimeticnanovaccines for reinforced dendritic cell spatiotemporal orchestration

Authors: Feng Liu , Lulu Tan, Zheng Dai , Yang Wang , Lei Huang , Yang Zhang , Qian Cheng , Xin Li , Miao-Deng Liu, Lin Wang, Zheng Wang

Journal: Nano Today

Doi: 10.1016/j.nantod.2023.102112

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Biomimetic Nanofibrillar Hydrogel with Cell-Adaptable Network for Enhancing Cellular Mechanotransduction, Metabolic Energetics, and Bone Regeneration

Authors: Xian Xie ， Zhuo Li , Xuefeng Yang , Boguang Yang , Zhixian Zong , Xuemei Wang , Liting Duan , Sien Lin , Gang Li , Liming Bian

Journal: J Am Chem Soc

PubMed ID: 37428960

Doi: 10.1021/jacs.3c02210

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Construction and characterization of a novel miniaturized filamentous phagemid for targeted mammalian gene transfer

Authors: Shirley Wong, Salma Jimenez, Roderick A Slavcev

Journal: Microb Cell Fact

PubMed ID: 37430278

Doi: 10.1186/s12934-023-02135-w

Products & Services: Proteins, Expression, Isolation and Analysis

Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants

Authors: Ebene R Haycroft, Samantha K Davis, Pradhipa Ramanathan, Ester Lopez, Ruth A Purcell, Li Lynn Tan, Phillip Pymm, Bruce D Wines, P Mark Hogarth, Adam K Wheatley, Jennifer A Juno, Samuel J Redmond, Nicholas A Gherardin, Dale I Godfrey, Wai-Hong Tham, Kevin John Selva, Stephen J Kent, Amy W Chung

Journal: Med Microbiol Immunol

PubMed ID: 37477828

Doi: 10.1007/s00430-023-00773-w

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Effectors of the Type VI Secretion System Have the Potential to Be Modified into Antimicrobial Peptides

Authors: Wenjia Lu, Hao Lu, Chenchen Wang, Gaoyan Wang, Wenqi Dong, Chen Tan

Journal: Microbiol Spectr

PubMed ID: 37470717

Doi: 10.1128/spectrum.00308-23

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Fusion of Substrate-Binding Domains Enhances the Catalytic Capacity of Keratinases and Promotes Enzymatic Conversion of Feather Waste

Authors: Xiaomei Ji, Zheng Peng, Jie Song, Guoqiang Zhang, Juan Zhang

Journal: J Agric Food Chem

PubMed ID: 37462367

Doi: 10.1021/acs.jafc.3c03064

Products & Services: Proteins, Expression, Isolation and Analysis

Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G

Authors: Takahide Kouno, Satoshi Shibata, Megumi Shigematsu, Jaekyung Hyun, Tae Gyun Kim, Hiroshi Matsuo, Matthias Wolf

Journal: Nat Commun

PubMed ID: 37419875

Doi: 10.1038/s41467-023-39796-5

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An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles

Authors: Huanhuan Li, Yixi Wu, Minke Li, Lu Guo, Yaqi Gao, Quan Wang, Jihua Zhang, Zhaohua Lai, Xing Zhang, Lixin Zhu, Ping Lan, Zihe Rao, Yingfang Liu, Huanhuan Liang

Journal: Nat Struct Mol Biol

PubMed ID: 37488357

Doi: 10.1038/s41594-023-01043-2

Products & Services: Proteins, Expression, Isolation and Analysis

Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity

Authors: Jay C Groppe, Guorong Lu, Mary R Tandang-Silvas, Anupama Pathi, Shruti Konda, Jingfeng Wu, Viet Q Le, Andria L Culbert, Eileen M Shore, Kristi A Wharton, Frederick S Kaplan

Journal: Biomolecules

PubMed ID: 37509165

Doi: 10.3390/biom13071129

Products & Services: Proteins, Expression, Isolation and Analysis

Tumor Site-Specific Cleavage Improves the Antitumor Efficacy of Antibody-Drug Conjugates

Authors: Keyuan Xu, Jiani Han, Liu Yang, Li Cao, Shuang Li, Zhangyong Hong

Journal: Int J Mol Sci

PubMed ID: 37446189

Doi: 10.3390/ijms241311011

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Peptide/Nanoparticle Biointerfaces for Multistep Tandem Catalysis

Authors: Yuliana Perdomo, Joseph M Slocik, David M Phillips, Marc R Knecht

Journal: J Am Chem Soc

PubMed ID: 37478168

Doi: 10.1021/jacs.3c04097

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Preclinical characterization of the efficacy and safety of biologic N-001 as a novel pain analgesic for post-operative acute pain treatment

Authors: Derek Allen, Samerender Nagam Hanumantharao, Rylie McDonell, Karen-Amanda Irvine, Peyman Sahbaie, David Clark, Paul Blum

Journal: Sci Rep

PubMed ID: 37479740

Doi: 10.1038/s41598-023-38618-4

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Low cross reactivity between wild type and deamidated AAV can lead to false negative results in immune monitoring T-cell assays

Authors: So Jin Bing, Stephanee Warrington, Ronit Mazor

Journal: Front Immunol

PubMed ID: 37469509

Doi: 10.3389/fimmu.2023.1211529

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RNA m5C methylation orchestrates BLCA progression via macrophage reprogramming

Authors: Dali Yan, Yongsong Xie, Liyuan Huang, Yi Zhang, Runhuan Gu, Huaibing Xie, Xing Huang, Hao Luo

Journal: J Cell Mol Med

PubMed ID: 37408139

Doi: 10.1111/jcmm.17826

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Hypoxic papillary thyroid carcinoma cells-secreted exosomes deliver miR-221-3p to normoxic tumor cells to elicit a pro-tumoral effect by regulating the ZFAND5

Authors: Fan Yu, Xianzhao Deng, Yong Zhong, Bomin Guo, Xiaoping Zhang, Bo Wu

Journal: Exp Cell Res

PubMed ID: 37488006

Doi: 10.1016/j.yexcr.2023.113716

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Structural Basis for the Ribonuclease Activity of a Thermostable CRISPR-Cas13a from Thermoclostridium caenicola

Authors: Feng Wang, Chendi Zhang, Haijiang Xu, Wanting Zeng, Lixin Ma, Zhuang Li

Journal: J Mol Biol

PubMed ID: 37442412

Doi: 10.1016/j.jmb.2023.168197

Products & Services: Proteins, Expression, Isolation and Analysis

Activation of PDGF Signaling in the Adult Muscle Stem Cell Niche in Patients With Type 2 Diabetes Mellitus

Authors: Alexandra Fahrner, Nikoleta Alchus Laiferová, Barbara Ukropcová, Jozef Ukropec, Jan Krützfeldt

Journal: J Clin Endocrinol Metab

PubMed ID: 36702759

Doi: 10.1210/clinem/dgad041

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Integrated immunoinformatics and subtractive proteomics approach for multi-epitope vaccine designing to combat TIGR4

Authors: Sami S Ashgar, Hani Faidah, Farkad Bantun, Naif A Jalal, Naeem F Qusty, Abdulla Darwish, Shafiul Haque, Essam M Janahi

Journal: Front Mol Biosci

PubMed ID: 37560463

Doi: 10.3389/fmolb.2023.1212119

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Long Non-coding RNA LINC00342 Promotes the Proliferation, Invasion, and Migration of Primary Hepatocellular Carcinoma Cells by Regulating the Expression of miRNA-19a-3p, miRNA-545-5p, and miRNA-203a-3p

Authors: Zong-Xi Yao, Jun-Hao Tu, Yu-Lin Liu, Xiao-Feng Xue, Lei Qin

Journal: Biochem Genet

PubMed ID: 37395850

Doi: 10.1007/s10528-023-10420-x

Products & Services: Proteins, Expression, Isolation and Analysis

A bistable autoregulatory module in the developing embryo commits cells to binary expression fates

Authors: Jiaxi Zhao, Mindy Liu Perkins, Matthew Norstad, Hernan G Garcia

Journal: Curr Biol

PubMed ID: 37453424

Doi: 10.1016/j.cub.2023.06.060

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Generation of Bioactive Peptides from sp and Assessment of Their Potential for Use in the Prevention of Hypertension, Inflammation and Pain

Authors: Maria Hayes, Rotimi E Aluko, Elena Aurino, Leticia Mora

Journal: Mar Drugs

PubMed ID: 37623703

Doi: 10.3390/md21080422

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TLR5S negatively regulates the TLR5M-mediated NF-κB signaling pathway in Epinephelus coioides

Authors: Liangge He, Xue Yu, Yulin Zhao, Haoran Lin, Yong Zhang, Danqi Lu

Journal: Int J Biol Macromol

PubMed ID: 37517756

Doi: 10.1016/j.ijbiomac.2023.126048

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Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays

Authors: Rui Qing, Mantian Xue, Jiayuan Zhao, Lidong Wu, Andreas Breitwieser, Eva Smorodina, Thomas Schubert, Giovanni Azzellino, David Jin, Jing Kong, Tomás Palacios, Uwe B Sleytr, Shuguang Zhang

Journal: Sci Adv

PubMed ID: 37478177

Doi: 10.1126/sciadv.adf1402

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An integrated genomic approach identifies follistatin as a target of the p63-epidermal growth factor receptor oncogenic network in head and neck squamous cell carcinoma

Authors: Akinsola Oyelakin, Jennifer Sosa, Kasturi Bala Nayak, Alexandra Glathar, Christian Gluck, Isha Sethi, Maria Tsompana, Norma Nowak, Michael Buck, Rose-Anne Romano, Satrajit Sinha

Journal: NAR Cancer

PubMed ID: 37492374

Doi: 10.1093/narcan/zcad038

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Author Correction: A pan-influenza antibody inhibiting neuraminidase via receptor mimicry

Authors: Corey Momont, Ha V Dang, Fabrizia Zatta, Kevin Hauser, Caihong Wang, Julia di Iulio, Andrea Minola, Nadine Czudnochowski, Anna De Marco, Kaitlin Branch, David Donermeyer, Siddhant Vyas, Alex Chen, Elena Ferri, Barbara Guarino, Abigail E Powell, Roberto Spreafico, Samantha S Yim, Dale R Balce, Istvan Bartha, Marcel Meury, Tristan I Croll, David M Belnap, Michael A Schmid, William Timothy Schaiff, Jessica L Miller, Elisabetta Cameroni, Amalio Telenti, Herbert W Virgin, Laura E Rosen, Lisa A Purcell, Antonio Lanzavecchia, Gyorgy Snell, Davide Corti, Matteo Samuele Pizzuto

Journal: Nature

PubMed ID: 37407829

Doi: 10.1038/s41586-023-06385-x

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Systemic delivery of specific and efficient CRISPR/Cas9 system targeting HPV16 oncogenes using LL-37 antimicrobial peptide in C57BL/6 mice

Authors: Niloofar Khairkhah, Azam Bolhassani, Farzad Rajaei, Reza Najafipour

Journal: J Med Virol

PubMed ID: 37403986

Doi: 10.1002/jmv.28934

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A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury

Authors: Chen Yang, Huidie Xu, Dong Yang, Yunhao Xie, Mingrui Xiong, Yu Fan, XiKai Liu, Yu Zhang, Yushuo Xiao, Yuchen Chen, Yihao Zhou, Liangliang Song, Chen Wang, Anlin Peng, Robert B Petersen, Hong Chen, Kun Huang, Ling Zheng

Journal: Nat Commun

PubMed ID: 37460623

Doi: 10.1038/s41467-023-40036-z

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Ice Recrystallization Inhibition Activity of Soy Protein Hydrolysates

Authors: Madison Fomich, Vermont P Día, Uvinduni I Premadasa, Benjamin Doughty, Hari B Krishnan, Tong Wang

Journal: J Agric Food Chem

PubMed ID: 37466256

Doi: 10.1021/acs.jafc.2c08701

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Transcriptomic analysis of hepatocytes reveals the association between ubiquitin-specific peptidase 1 and yes-associated protein 1 during liver regeneration

Authors: Yalei Zhao, Fen Zhang, Xiaoli Zhang, Zuhong Li, Qian Li, Tianzhi Ni, Ruojing Wang, Liangru Liu, Yingli He, Yingren Zhao

Journal: Regen Ther

PubMed ID: 37534236

Doi: 10.1016/j.reth.2023.07.004

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The ubiquitin-protein ligase MIEL1 localizes to peroxisomes to promote seedling oleosin degradation and lipid droplet mobilization

Authors: Melissa S Traver , Bonnie Bartel

Journal: Proc Natl Acad Sci U S A .

PubMed ID: 37410814

Doi: 10.1073/pnas.2304870120

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Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity

Authors: Hudie Wei , Haolan Wang , Genxin Wang , Lingzhi Qu , Longying Jiang , Shuyan Dai , Xiaojuan Chen , Ye Zhang , Zhuchu Chen , Youjun Li , Ming Guo , Yongheng Chen

Journal: Nat Commun .

PubMed ID: 37463921

Doi: 10.1038/s41467-023-40087-2

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Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer

Authors: Apostolia M Tsimberidou, Kerstin Guenther, Borje S Andersson, Regina Mendrzyk, Amir Alpert, Claudia Wagner, Anna Nowak, Katrin Aslan, Arun Satelli, Fabian Richter, Sabrina Kuttruff-Coqui, Oliver Schoor, Jens Fritsche, Zoe Coughlin, Ali S Mohamed, Kerry Sieger, Becky Norris, Rita Ort, Jennifer Beck, Henry Hiep Vo, Franziska Hoffgaard, Manuel Ruh, Linus Backert, Ignacio I Wistuba, David Fuhrmann, Nuhad K Ibrahim, Van Karlyle Morris, Bryan K Kee, Daniel M Halperin, Graciela M Nogueras-Gonzalez, Partow Kebriaei, Elizabeth J Shpall, David Vining, Patrick Hwu, Harpreet Singh, Carsten Reinhardt, Cedrik M Britten, Norbert Hilf, Toni Weinschenk, Dominik Maurer, Steffen Walter

Journal: Cancer Immunol Res

PubMed ID: 37172100

Doi: 10.1158/2326-6066.CIR-22-0444

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Protein oxidation increases SAMHD1 binding ssDNA via its regulatory site

Authors: Theresa L Simermeyer, Stephanie Batalis, LeAnn C Rogers, Owen J Zalesak, Thomas Hollis

Journal: Nucleic Acids Res

PubMed ID: 37246644

Doi: 10.1093/nar/gkad447

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Functionally diverse front-end desaturases are widespread in the phylum Annelida

Authors: Marc Ramos-Llorens, Francisco Hontoria, Juan C Navarro, David E K Ferrier, Óscar Monroig

Journal: Biochim Biophys Acta Mol Cell Biol Lipids

PubMed ID: 37517549

Doi: 10.1016/j.bbalip.2023.159377

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Caspase-mediated LPS sensing and pyroptosis signaling in

Authors: Shouwen Chen, Shuxin Li, Hao Chen, Yuxin Gong, Dahai Yang, Yuanxing Zhang, Qin Liu

Journal: Sci Adv

PubMed ID: 37478191

Doi: 10.1126/sciadv.adh4054

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Network pharmacology, molecular docking and experimental verification of the mechanism of huangqi-jixuecao herb pair in treatment of peritoneal fibrosis

Authors: Huibo Dai , Yun Shan , Manshu Yu ， Funing Wang , Ziren Zhou , Jinyi Sun , Li Sheng , Liyan Huang , Meixiao Sheng

Journal: J Ethnopharmacol .

PubMed ID: 37437794

Doi: 10.1016/j.jep.2023.116874

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Antibody binding of amyloid beta peptide epimers/isomers and ramifications for immunotherapies and drug development

Authors: Elizabeth R Readel, Arzoo Patel, Joshua I Putman, Siqi Du, Daniel W Armstrong

Journal: Sci Rep

PubMed ID: 37524807

Doi: 10.1038/s41598-023-38788-1

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A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation

Authors: Karla Wolf, Jan Kosinski, Toby J Gibson, Nicole Wesch, Volker Dötsch, Maurizio Genuardi, Emanuela Lucci Cordisco, Stefan Zeuzem, Angela Brieger, Guido Plotz

Journal: Nucleic Acids Res

PubMed ID: 37224528

Doi: 10.1093/nar/gkad418

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Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States

Authors: Aijing Feng, Sarah Bevins, Jeff Chandler, Thomas J DeLiberto, Ria Ghai, Kristina Lantz, Julianna Lenoch, Adam Retchless, Susan Shriner, Cynthia Y Tang, Suxiang Sue Tong, Mia Torchetti, Anna Uehara, Xiu-Feng Wan

Journal: Nat Commun

PubMed ID: 37429851

Doi: 10.1038/s41467-023-39782-x

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Siglec15 promotes the migration of thyroid carcinoma cells by enhancing the EGFR protein stability

Authors: Sijing Huang, Zhi Ji, Jinqiang Xu, Yuerong Yang, BingRui Wu, Qihang Chen, Shuting Geng, Yu Si, Jiayue Chen, Yuanyan Wei, Cong Wang, Zhilong Ai, Jianhai Jiang

Journal: Glycobiology

PubMed ID: 37129515

Doi: 10.1093/glycob/cwad037

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Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

Authors: Camille N Pierre, Lily E Adams, Kara Anasti, Derrick Goodman, Sherry Stanfield-Oakley, John M Powers, Dapeng Li, Wes Rountree, Yunfei Wang, Robert J Edwards, S Munir Alam, Guido Ferrari, Georgia D Tomaras, Barton F Haynes, Ralph S Baric, Kevin O Saunders

Journal: biorxiv

PubMed ID: 37546738

Doi: 10.1101/2023.07.25.550460

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The structure and mechanism of action of a distinct class of dicistrovirus intergenic region IRESs

Authors: Irina S Abaeva , Christina Young , Reid Warsaba , Nadiyah Khan , Lan Vy Tran , Eric Jan , Tatyana V Pestova , Christopher U T Hellen

Journal: Nucleic Acids Res .

PubMed ID: 37427788

Doi: 10.1093/nar/gkad569

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Unravelling the Therapeutic Potential of Antibiotics in Hypoxia in a Breast Cancer MCF-7 Cell Line Model

Authors: Almaz A Akhunzianov , Alfiya I Nesterova , Sjoerd Wanrooij , Yulia V Filina , Albert A Rizvanov , Regina R Miftakhova

Journal: Int J Mol Sci .

PubMed ID: 37511298

Doi: 10.3390/ijms241411540

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A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity

Authors: Mingfeng Zhang , Yuanyue Shan , Charles D Cox , Duanqing Pei

Journal: Nat Commun .

PubMed ID: 37402734

Doi: 10.1038/s41467-023-39688-8

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A Novel Bispecific Antibody for EpCAM-Directed Inhibition of the CD73/Adenosine Immune Checkpoint in Ovarian Cancer

Authors: Emily Maria Ploeg, Isabel Britsch, Anne Paulien van Wijngaarden, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Douwe Freerk Samplonius, Wijnand Helfrich

Journal: Cancers (Basel)

PubMed ID: 37509310

Doi: 10.3390/cancers15143651

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Probing Substrate Transport Effects on Enzymatic Hydrogen Catalysis: An Alternative Proton Transfer Pathway in Putatively Sensory [FeFe] Hydrogenase

Authors: Princess R Cabotaje, Kaija Walter, Afridi Zamader, Ping Huang, Felix Ho, Henrik Land, Moritz Senger, Gustav Berggren

Journal: ACS Catal

PubMed ID: 37560193

Doi: 10.1021/acscatal.3c02314

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Intratumoral immune triads are required for adoptive T cell therapy-mediated elimination of solid tumors

Authors: Gabriel Espinosa-Carrasco, Aurora Scrivo, Paul Zumbo, Asim Dave, Doron Betel, Matthew Hellmann, Bryan M Burt, Hyun-Sung Lee, Andrea Schietinger

Journal: biorxiv

PubMed ID: 37461721

Doi: 10.1101/2023.07.03.547423

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Establishment and characterization of an SV40 immortalized chicken intestinal epithelial cell line

Authors: Federico Ghiselli, Martina Felici, Andrea Piva, Ester Grilli

Journal: Poult Sci

PubMed ID: 37517361

Doi: 10.1016/j.psj.2023.102864

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Author Correction: Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses

Authors: Fredrika Hellgren, Alberto Cagigi, Rodrigo Arcoverde Cerveira, Sebastian Ols, Theresa Kern, Ang Lin, Bengt Eriksson, Michael G Dodds, Edith Jasny, Kim Schwendt, Conrad Freuling, Thomas Müller, Martin Corcoran, Gunilla B Karlsson Hedestam, Benjamin Petsch, Karin Loré

Journal: Nat Commun

PubMed ID: 37429868

Doi: 10.1038/s41467-023-39754-1

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PAQR9 regulates glucose homeostasis in diabetic mice and modulates insulin secretion in β cells in vitro under stress conditions

Authors: Zixuan Li, Yijun Lin, Shixuan Zhuo, Jinzhu Chen, Lingling Chen, Shuying Wang, Yan Chen

Journal: Mol Cell Endocrinol

PubMed ID: 37499998

Doi: 10.1016/j.mce.2023.112032

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Prediction of cooperative homeodomain DNA binding sites from high-throughput-SELEX data

Authors: Brittany Cain, Jordan Webb, Zhenyu Yuan, David Cheung, Hee-Woong Lim, Rhett A Kovall, Matthew T Weirauch, Brian Gebelein

Journal: Nucleic Acids Res

PubMed ID: 37114997

Doi: 10.1093/nar/gkad318

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Increase in SARS-CoV-2 Seroprevalence in UK Domestic Felids Despite Weak Immunogenicity of Post-Omicron Variants

Authors: Grace B Tyson, Sarah Jones, Chloe Montreuil-Spencer, Nicola Logan, Sam Scott, Hagar Sasvari, Michael McDonald, Leigh Marshall, Pablo R Murcia, Brian J Willett, William Weir, Margaret J Hosie

Journal: Viruses

PubMed ID: 37632004

Doi: 10.3390/v15081661

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Systematic investigation on the multi-scale mechanisms of bitter peptide self-assembly for flavor modulation

Authors: Rong Zhang, Wei Jia

Journal: Food Chem

PubMed ID: 37541037

Doi: 10.1016/j.foodchem.2023.137063

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Systematic analysis of the impact of phosphorylation and O-GlcNAcylation on protein subcellular localization

Authors: Senhan Xu, Suttipong Suttapitugsakul, Ming Tong, Ronghu Wu

Journal: Cell Rep

PubMed ID: 37453062

Doi: 10.1016/j.celrep.2023.112796

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A Highly-Parallelized and Low-Sample-Size chip for Simultaneous Detectison of Protein and Nucleic Acid Biomarkers in Hepatocellular Carcinoma

Authors: Yingxue Li, Qi Xu, Wei Zhang, Qi Yang, Zhen Guo, Chuanyu Li, Zhiqi Zhang, Qiongzhu Dong, Haoting Sun, Changsong Zhang, Chao Li, Jia Yao, Jinze Li, Lunxiu Qin, Lianqun Zhou

Journal: Sensors and Actuators B: Chemical

Doi: 10.1016/j.snb.2023.134112

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Production of the antidepressant orcinol glucoside in Yarrowia lipolytica with yields over 6,400-fold higher than plant extraction

Authors: Bihuan Chen , Xiaonan Liu , Yina Wang , Jie Bai , Xiangyu Liu , Guisheng Xiang , Wei Liu , Xiaoxi Zhu , Jian Cheng , Lina Lu , Guanghui Zhang , Ge Zhang, Zongjie Dai, Shuhui Zi , Shengchao Yang, Huifeng Jiang

Journal: PLoS Biol .

PubMed ID: 37279234

Doi: 10.1371/journal.pbio.3002131

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Discovery of deaminase functions by structure-based protein clustering

Authors: Jiaying Huang , Qiupeng Lin , Hongyuan Fei , Zixin He , Hu Xu , Yunjia Li , Kunli Qu , Peng Han , Qiang Gao , Boshu Li , Guanwen Liu , Lixiao Zhang , Jiacheng Hu , Rui Zhang , Erwei Zuo , Yonglun Luo , Yidong Ran , Jin-Long Qiu , Kevin Tianmeng Zhao , Caixia Gao

Journal: Cell .

PubMed ID: 37379837

Doi: 10.1016/j.cell.2023.05.041

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Cell targeting and immunostimulatory properties of a novel Fcγ-receptor-independent agonistic anti-CD40 antibody in rhesus macaques

Authors: Xianglei Yan, Sebastian Ols, Rodrigo Arcoverde Cerveira, Klara Lenart, Fredrika Hellgren, Kewei Ye, Alberto Cagigi, Marcus Buggert, Falk Nimmerjahn, Jesper Falkesgaard Højen, Daniel Parera, Ulrich Pessara, Stephan Fischer, Karin Loré

Journal: Cell Mol Life Sci

PubMed ID: 37353664

Doi: 10.1007/s00018-023-04828-2

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Melatonin attenuates monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats via activation of Sirtuin-3

Authors: Xiaofei Ren, Kui Xu, Jianming Xu, Qiao Mei

Journal: J Biochem Mol Toxicol

PubMed ID: 37350538

Doi: 10.1002/jbt.23422

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Erythroid lineage chromatin accessibility maps facilitate identification and validation of NFIX as a fetal hemoglobin repressor

Authors: Mudit Chaand, Chris Fiore, Brian Johnston, Anthony D'Ippolito, Diane H Moon, John P Carulli, Jeffrey R Shearstone

Journal: Commun Biol

PubMed ID: 37316562

Doi: 10.1038/s42003-023-05025-4

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ATXN3 controls DNA replication and transcription by regulating chromatin structure

Authors: Esperanza Hernández-Carralero, Elisa Cabrera, Gara Rodríguez-Torres, Yeray Hernández-Reyes, Abhay N Singh, Cristina Santa-María, José Miguel Fernández-Justel, Roel C Janssens, Jurgen A Marteijn, Bernd O Evert, Niels Mailand, María Gómez, Kristijan Ramadan, Veronique A J Smits, Raimundo Freire

Journal: Nucleic Acids Res

PubMed ID: 36971114

Doi: 10.1093/nar/gkad212

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Detection of phosphorylation post-translational modifications along single peptides with nanopores

Authors: Ian C Nova, Justas Ritmejeris, Henry Brinkerhoff, Theo J R Koenig, Jens H Gundlach, Cees Dekker

Journal: Nat Biotechnol

PubMed ID: 37386295

Doi: 10.1038/s41587-023-01839-z

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Electrochemical biosensor strategy combining DNA entropy-driven technology to activate CRISPR-Cas13a activity and triple-stranded nucleic acids to detect SARS-CoV-2 RdRp gene

Authors: Chenyi Zhuo, Zichun Song, Jiuying Cui, Yuanxun Gong, Qianli Tang, Kai Zhang, Xinlei Song, Xianjiu Liao

Journal: Mikrochim Acta

PubMed ID: 37351704

Doi: 10.1007/s00604-023-05848-2

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Optimization of mammalian expression vector by cis-regulatory element combinations

Authors: Lu-Yu Zhou, Shuang Zhang, Li-Yun Li, Guo-Yu Yang, Lei Zeng

Journal: Mol Genet Genomics

PubMed ID: 37318628

Doi: 10.1007/s00438-023-02042-0

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Rise of the RNA machines - self-amplification in mRNA vaccine design

Authors: Jerome D G Comes, Gorben P Pijlman, Tessy A H Hick

Journal: Trends Biotechnol

PubMed ID: 37328401

Doi: 10.1016/j.tibtech.2023.05.007

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Lymphocyte infiltration and antitumoral effect promoted by cytotoxic inflammatory proteins formulated as self-assembling, protein-only nanoparticles

Authors: Carlos Martínez-Torró, Lorena Alba-Castellón, Luis Miguel Carrasco-Díaz, Naroa Serna, Laura Imedio, Alberto Gallardo, Isolda Casanova, Ugutz Unzueta, Esther Vázquez, Ramón Mangues, Antonio Villaverde

Journal: Biomed Pharmacother

PubMed ID: 37276641

Doi: 10.1016/j.biopha.2023.114976

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Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides

Authors: Xueli Cao, Yu Xiao, Erin Huiting, Xujun Cao, Dong Li, Jie Ren, Linlin Guan, Yu Wang, Lingyin Li, Joseph Bondy-Denomy, Yue Feng

Journal: biorxiv

PubMed ID: 37398474

Doi: 10.1101/2023.06.01.543220

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Enzyme assembly on nanoparticle scaffolds enhances cofactor recycling and improves coupled reaction kinetics

Authors: Joyce C Breger, Ellen R Goldman, Kimihiro Susumu, Eunkeu Oh, Christopher M Green, Shelby L Hooe, Meghna Thakur, Igor L Medintz, Gregory A Ellis

Journal: Nanoscale

PubMed ID: 37272342

Doi: 10.1039/d3nr00729d

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In Vitro and In Vivo Efficacy of a Stroma-Targeted, Tumor Microenvironment Responsive Oncolytic Adenovirus in Different Preclinical Models of Cancer

Authors: Ana Alfano, Eduardo G A Cafferata, Mariela Gangemi, Alejandro Nicola Candia, Cristian M Malnero, Ismael Bermudez, Mauricio Vargas Lopez, Gregorio David Ríos, Cecilia Rotondaro, Nicasio Cuneo, David T Curiel, Osvaldo L Podhajcer, Maria Veronica Lopez

Journal: Int J Mol Sci

PubMed ID: 37373140

Doi: 10.3390/ijms24129992

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Heme catabolism mediated by heme oxygenase in uninfected interstitial cells enables efficient symbiotic nitrogen fixation in Lotus japonicus nodules

Authors: Yu Zhou, Longlong Wang, Maria Carmen Rubio, Carmen Pérez-Rontomé, Yumiao Zhou, Yongmei Qi, Tao Tian, Weiqing Zhang, Qiuling Fan, Manuel Becana, Deqiang Duanmu

Journal: New Phytol

PubMed ID: 37329247

Doi: 10.1111/nph.19074

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NeuroMabSeq: high volume acquisition, processing, and curation of hybridoma sequences and their use in generating recombinant monoclonal antibodies and scFvs for neuroscience research

Authors: Keith G Mitchell, Belvin Gong, Samuel S Hunter, Diana Burkart-Waco, Clara E Gavira-O'Neill, Kayla M Templeton, Madeline E Goethel, Malgorzata Bzymek, Leah M MacNiven, Karl D Murray, Matthew L Settles, Lutz Froenicke, James S Trimmer

Journal: biorxiv

PubMed ID: 37425915

Doi: 10.1101/2023.06.28.546392

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N-terminal intrinsic disorder is an ancestral feature of Gγ subunits that influences the balance between different Gβγ signaling axes in yeast

Authors: Xinya Su, Yui Tik Pang, Wei Li, J C Gumbart, Joshua Kelley, Matthew Torres

Journal: J Biol Chem

PubMed ID: 37354971

Doi: 10.1016/j.jbc.2023.104947

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Exploration of T cell immune responses by expression of a dominant-negative SHP1 and SHP2

Authors: Julia Taylor, Anna Bulek, Isaac Gannon, Mathew Robson, Evangelia Kokalaki, Thomas Grothier, Callum McKenzie, Mohamed El-Kholy, Maria Stavrou, Charlotte Traynor-White, Wen Chean Lim, Panagiota Panagiotou, Saket Srivastava, Vania Baldan, James Sillibourne, Mathieu Ferrari, Martin Pule, Simon Thomas

Journal: Front Immunol

PubMed ID: 37334382

Doi: 10.3389/fimmu.2023.1119350

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RNA-binding is an ancient trait of the Annexin family

Authors: Sudarshan S Patil, Vipul Panchal, Trude Røstbø, Sofya Romanyuk, Hanne Hollås, Ruth Brenk, Ann Kari Grindheim, Anni Vedeler

Journal: Front Cell Dev Biol

PubMed ID: 37397259

Doi: 10.3389/fcell.2023.1161588

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MAP2 caps tau fibrils and inhibits aggregation

Authors: Michael R Holden, Brad J Krzesinski, Hilary A Weismiller, Justin R Shady, Martin Margittai

Journal: J Biol Chem

PubMed ID: 37286038

Doi: 10.1016/j.jbc.2023.104891

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A Novel Conserved Linear Neutralizing Epitope on the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein

Authors: Rong-Hong Hua, Shu-Jian Zhang, Bei Niu, Jin-Ying Ge, Ting Lan, Zhi-Gao Bu

Journal: Microbiol Spectr

PubMed ID: 37306579

Doi: 10.1128/spectrum.01190-23

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The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT)

Authors: Cory M Nadel, Aye C Thwin, Matthew Callahan, Kanghyun Lee, Emily Connelly, Charles S Craik, Daniel R Southworth, Jason E Gestwicki

Journal: J Mol Biol

PubMed ID: 37330289

Doi: 10.1016/j.jmb.2023.168026

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Mutations F352A and Y528A in human HSP90α reduce fibronectin association and fibrillogenesis in cell-derived matrices

Authors: Abir Chakraborty, Ronald Tonui, Adrienne Lesley Edkins

Journal: Cell Stress Chaperones

PubMed ID: 37353709

Doi: 10.1007/s12192-023-01362-9

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Identification and targeting of protein tyrosine kinase 7 (PTK7) as an immunotherapy candidate for neuroblastoma

Authors: Jasmine Y Lee, Hunter C Jonus, Arhanti Sadanand, Gianna M Branella, Victor Maximov, Suttipong Suttapitugsakul, Matthew J Schniederjan, Jenny Shim, Andrew Ho, Kiran K Parwani, Andrew Fedanov, Adeiye A Pilgrim, Jordan A Silva, Robert W Schnepp, Christopher B Doering, Ronghu Wu, H Trent Spencer, Kelly C Goldsmith

Journal: Cell Rep Med

PubMed ID: 37343516

Doi: 10.1016/j.xcrm.2023.101091

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The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics

Authors: Sook Wah Yee, Christian Macdonald, Darko Mitrovic, Xujia Zhou, Megan L Koleske, Jia Yang, Dina Buitrago Silva, Patrick Rockefeller Grimes, Donovan Trinidad, Swati S More, Linda Kachuri, John S Witte, Lucie Delemotte, Kathleen M Giacomini, Willow Coyote-Maestas

Journal: biorxiv

PubMed ID: 37333090

Doi: 10.1101/2023.06.06.543963

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Efficient production of fluorophore-labeled CC chemokines for biophysical studies using recombinant enterokinase and recombinant sortase

Authors: Wenyan Guan, Ning Zhang, Arjan Bains, Mourad Sadqi, Cynthia M Dupureur, Patricia J LiWang

Journal: Biopolymers

PubMed ID: 37341434

Doi: 10.1002/bip.23557

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Nullomer peptide increases immune cell infiltration and reduces tumor metabolism in triple negative breast cancer mouse model

Authors: Nilufar Ali, Cody Wolf, Swarna Kanchan, Shivakumar R Veerabhadraiah, Laura Bond, Matthew W Turner, Cheryl L Jorcyk, Greg Hampikian

Journal: Res Sq

PubMed ID: 37461536

Doi: 10.21203/rs.3.rs-3097552/v1

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miR‑124 inhibits cardiomyocyte apoptosis in myocardial ischaemia‑reperfusion injury by activating mitochondrial calcium uniporter regulator 1

Authors: Linlin Guo, Chaoying Liu, Chunyan Jiang, Yanhan Dong, Lynn Htet Htet Aung, Han Ding, Yanyan Gao

Journal: Mol Med Rep

PubMed ID: 37326122

Doi: 10.3892/mmr.2023.13031

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