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Structural role of K224 in taniborbactam inhibition of NDM-1

Authors: Daisuke Ono, Maria F Mojica, Christopher R Bethel, Yoshikazu Ishii, Salvador I Drusin, Diego M Moreno, Alejandro J Vila, Robert A Bonomo

Journal: Antimicrob Agents Chemother

PubMed ID: 38174924

Doi: 10.1128/aac.01332-23

Products & Services: Molecular Biology Reagents

Production of anti-human cannabinoid receptor 2 (CB2) monoclonal antibody using non-viral vector induced human CB2 expressing myeloma as an immunogen

Authors: Jindaphun Kanyaruck, Takheaw Nuchjira, Putpim Chaochetdhapada, Laopajon Witida, Kotemul Kamonporn, Chaiwut Ratthakorn, Pata Supansa, Kasinrerk Watchara

Journal: Asian Pac J Allergy Immunol

PubMed ID: 38183645

Doi: 10.12932/AP-020723-1646

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Effect of l-serine and magnesium ions on the functional properties of human phosphoserine phosphatase and its pathogenetic variants

Authors: Francesco Marchesani, Valeria Buoli Comani, Stefano Bruno, Andrea Mozzarelli, Mauro Carcelli, Loredano Pollegioni, Laura Caldinelli, Alessio Peracchi, Barbara Campanini

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 38278334

Doi: 10.1016/j.bbadis.2024.167034

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Long chain capsaicin analogues synthetized by CALB-CLEAs show cytotoxicity on glioblastoma cell lines

Authors: Tania Diaz-Vidal, Vicente Paúl Armenta-Pérez, Luis Carlos Rosales-Rivera, Georgina Cristina Basulto-Padilla, Raúl Balam Martínez-Pérez, Juan Carlos Mateos-Díaz, Yanet K Gutiérrez-Mercado, Alejandro A Canales-Aguirre, Jorge A Rodríguez

Journal: Appl Microbiol Biotechnol

PubMed ID: 38217255

Doi: 10.1007/s00253-023-12856-y

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The Anti-SARS-CoV-2 IgG1 and IgG3 Antibody Isotypes with Limited Neutralizing Capacity against Omicron Elicited in a Latin Population a Switch toward IgG4 after Multiple Doses with the mRNA Pfizer-BioNTech Vaccine

Authors: Ana M Espino, Albersy Armina-Rodriguez, Laura Alvarez, Carlimar Ocasio-Malavé, Riseilly Ramos-Nieves, Esteban I Rodriguez Martinó, Paola López-Marte, Esther A Torres, Carlos A Sariol

Journal: Viruses

PubMed ID: 38399963

Doi: 10.3390/v16020187

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Cytoophidia Influence Cell Cycle and Size in

Authors: Ruolan Deng, Yi-Lan Li, Ji-Long Liu

Journal: Int J Mol Sci

PubMed ID: 38203781

Doi: 10.3390/ijms25010608

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BBS genes are involved in accelerated proliferation and early differentiation of BBS-related tissues

Authors: Avital Horwitz, Noa Levi-Carmel, Olga Shnaider, Ruth Birk

Journal: Differentiation

PubMed ID: 38215537

Doi: 10.1016/j.diff.2024.100745

Products & Services: Molecular Biology Reagents

ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism

Authors: Edrees H Rashan, Abigail K Bartlett, Daven B Khana, Jingying Zhang, Raghav Jain, Andrew J Smith, Zakery N Baker, Taylor Cook, Alana Caldwell, Autumn R Chevalier, Brian F Pfleger, Peng Yuan, Daniel Amador-Noguez, Judith A Simcox, David J Pagliarini

Journal: biorxiv

PubMed ID: 38260250

Doi: 10.1101/2024.01.09.574893

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Ewing Sarcoma Related protein 1 recognizes R-loops by binding DNA forks

Authors: Michelle A Lay, Valery F Thompson, Ajibola D Adelakun, Jacob C Schwartz

Journal: biorxiv

PubMed ID: 38293191

Doi: 10.1101/2024.01.20.576463

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The adc1 knockout with proC overexpression in Synechocystis sp PCC 6803 induces a diversion of acetyl-CoA to produce more polyhydroxybutyrate

Authors: Suthira Utharn, Saowarath Jantaro

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 38218963

Doi: 10.1186/s13068-024-02458-9

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Blocking the E2F transcription factor 1/high-mobility group box 2 pathway enhances the intervention effects of α-santalol on the malignant behaviors of liver cancer cells

Authors: Hui Wang, Min Tang, Erli Pei, Ying Shen, Aili Wang, Moubin Lin

Journal: Int J Biochem Cell Biol

PubMed ID: 38219975

Doi: 10.1016/j.biocel.2024.106516

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A glycoside hydrolase 30 protein BpXynC of Bacillus paralicheniformis NMSW12 recognized as A MAMP triggers plant immunity response

Authors: Chenjie Yu, Xiaoli Liang, Yan Song, Qurban Ali, Xihao Yang, Linli Zhu, Qin Gu, Vladislav Kuptsov, Emilia Kolomiets, Huijun Wu, Xuewen Gao

Journal: Int J Biol Macromol

PubMed ID: 38286384

Doi: 10.1016/j.ijbiomac.2024.129750

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TMEM219 regulates the transcription factor expression and proliferation of beta cells

Authors: Francesca D'Addio, Emma Assi, Anna Maestroni, Giada Rossi, Vera Usuelli, Adriana Petrazzuolo, Marta Nardini, Cristian Loretelli, Moufida Ben Nasr, Paolo Fiorina

Journal: Front Endocrinol (Lausanne)

PubMed ID: 38318298

Doi: 10.3389/fendo.2024.1306127

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Antibody reactive immunomes of and are diverse and defined by conformational antigenic determinants

Authors: Tian Luo, Jignesh G Patel, Xiaofeng Zhang, Jere W McBride

Journal: Front Cell Infect Microbiol

PubMed ID: 38264730

Doi: 10.3389/fcimb.2023.1321291

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Comparison of mouse models of microbial experience reveals differences in microbial diversity and response to vaccination

Authors: Autumn E Sanders, Henriette Arnesen, Frances K Shepherd, Dira S Putri, Jessica K Fiege, Mark J Pierson, Shanley N Roach, Harald Carlsen, David Masopust, Preben Boysen, Ryan A Langlois

Journal: mSphere

PubMed ID: 38286428

Doi: 10.1128/msphere.00654-23

Products & Services: Recombinant Proteins

A small-molecule activation mechanism that directly opens the KCNQ2 channel

Authors: Shaoying Zhang, Demin Ma, Kun Wang, Ya Li, Zhenni Yang, Xiaoxiao Li, Junnan Li, Jiangnan He, Lianghe Mei, Yangliang Ye, Zongsheng Chen, Juwen Shen, Panpan Hou, Jiangtao Guo, Qiansen Zhang, Huaiyu Yang

Journal: Nat Chem Biol

PubMed ID: 38167918

Doi: 10.1038/s41589-023-01515-y

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Functional characterization of the dimeric form of PDGF-derived fusion peptide fabricated based on theoretical arguments

Authors: Maryam Sadeghi-Ardebili, Sadegh Hasannia, Bahareh Dabirmanesh, Ramazan Ali Khavari-Nejad

Journal: Sci Rep

PubMed ID: 38200288

Doi: 10.1038/s41598-024-51707-2

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Endolysin NC5 improves early cloxacillin treatment in a mouse model of Streptococcus uberis mastitis

Authors: Niels Vander Elst, Julie Bellemans, Rob Lavigne, Yves Briers, Evelyne Meyer

Journal: Appl Microbiol Biotechnol

PubMed ID: 38204128

Doi: 10.1007/s00253-023-12820-w

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Irreversible light-activated SpyLigation mediates split-protein assembly in 4D

Authors: Brizzia G Munoz-Robles, Cole A DeForest

Journal: Nat Protoc

PubMed ID: 38253657

Doi: 10.1038/s41596-023-00938-0

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Recombinantly expressed virus-like particles (VLPs) of canine circovirus for development of an indirect ELISA

Authors: Alison Neef, Babu Kanti Nath, Tridip Das, Daniel Luque, Jade K Forwood, Shane R Raidal, Shubhagata Das

Journal: Vet Res Commun

PubMed ID: 38163840

Doi: 10.1007/s11259-023-10290-z

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Let-7a-5p Regulates Animal Lipid Accumulation by Targeting Srebf2 and Thbs1 Signaling

Authors: Jiahao Shao , Genglong Jiang , Yanhong Li, Meigui Wang, Tao Tang, Jie Wang , Xianbo Jia and Songjia Lai

Journal: Int. J. Mol. Sci

Doi: 10.3390/ijms25020894

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Biosynthesis of 10-Hydroxy-2-decenoic Acid through a One-Step Whole-Cell Catalysis

Authors: Ke Fang , Ziting Xu , Lu Yang , Quan Cui , Bowen Du , Huijing Liu , Ruiming Wang , Piwu Li , Jing Su , Junqing Wang

Journal: J Agric Food Chem .

PubMed ID: 38175798

Doi: 10.1021/acs.jafc.3c08142

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Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif

Authors: Wuyang Shi , Shibo Sun , Haowen Liu , Yao Meng , Kangshuai Ren , Guoying Wang , Minghui Liu , Jiaqi Wu , Yue Zhang , Huang Huang , Meiyun Shi , Weiping Xu , Qiang Ma , Bingbing Sun , Jianqiang Xu

Journal: Redox biology

Doi: 10.1016/j.redox.2024.103050

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N-acetyltransferase 10 regulates alphavirus replication via N4- acetylcytidine (ac4C) modification of the lymphocyte antigen six family member E (LY6E) mRNA

Authors: Yamei Dang , Jia Li , Yuchang Li , Yuan Wang , Yajing Zhao , Ningbo Zhao , Wanying Li , Hui Zhang , Chuantao Ye , Hongwei Ma , Liang Zhang , He Liu , Yangchao Dong , Min Yao , Yingfeng Lei , Zhikai Xu , Fanglin Zhang , Wei Ye

Journal: J Virol .

PubMed ID: 38169284

Doi: 10.1128/jvi.01350-23

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Structural basis of Gabija anti-phage defence and viral immune evasion

Authors: Sadie P Antine, Alex G Johnson, Sarah E Mooney, Azita Leavitt, Megan L Mayer, Erez Yirmiya, Gil Amitai, Rotem Sorek, Philip J Kranzusch

Journal: Nature

PubMed ID: 37992757

Doi: 10.1038/s41586-023-06855-2

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A synthetic differentiation circuit in Escherichia coli for suppressing mutant takeover

Authors: David S Glass 1, Anat Bren 2, Elizabeth Vaisbourd 2, Avi Mayo 2, Uri Alon

Journal: Cell

PubMed ID: 38320549

Doi: 10.1016/j.cell.2024.01.024

Products & Services: Plasmid DNA Preparation

Sirtuin 3 is required for the dexmedetomidine-mediated alleviation of inflammation and oxidative stress in nephritis

Authors: Kai Lu , Xinlong Li , Jie Wu

Journal: Immunity

PubMed ID: 38270316

Doi: 10.1002/iid3.1135

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Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines

Authors: Gisele Nishiguchi , Lauren G Mascibroda , Sarah M Young , Elizabeth A Caine , Sherif Abdelhamed , Jeffrey J Kooijman , Darcie J Miller , Sourav Das , Kevin McGowan , Anand Mayasundari , Zhe Shi , Juan M Barajas , Ryan Hiltenbrand , Anup Aggarwal , Yunchao Chang , Vibhor Mishra , Shilpa Narina , Melvin Thomas , Allister J Loughran , Ravi Kalathur , Kaiwen Yu , Suiping Zhou , Xusheng Wang , Anthony A High , Junmin Peng , Shondra M Pruett-Miller , Danette L Daniels , Marjeta Urh , Anang A Shelat , Charles G Mullighan , Kristin M Riching , Guido J R Zaman , Marcus Fischer , Jeffery M Klco , Zoran Rankovic

Journal: Nat Commun

PubMed ID: 38228616

Doi: 10.1038/s41467-024-44698-1

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PIEZO1 loss-of-function compound heterozygous mutations in the rare congenital human disorder Prune Belly Syndrome

Authors: Nathalia G Amado , Elena D Nosyreva , David Thompson , Thomas J Egeland , Osita W Ogujiofor , Michelle Yang , Alexandria N Fusco , Niccolo Passoni , Jeremy Mathews , Brandi Cantarel , Linda A Baker , Ruhma Syeda

Journal: Nat Commun

PubMed ID: 38184690

Doi: 10.1038/s41467-023-44594-0

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A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential

Authors: Gregory H Bird , J J Patten , William Zavadoski , Nicole Barucci , Marina Godes , Benjamin M Moyer , Callum D Owen , Paul DaSilva-Jardine , Donna S Neuberg , Richard A Bowen , Robert A Davey , Loren D Walensky

Journal: Nat Commun

PubMed ID: 38177138

Doi: 10.1038/s41467-023-44361-1

Products & Services: Plasmid DNA Preparation

Massively parallel profiling of RNA-targeting CRISPR-Cas13d

Authors: Hung-Che Kuo , Joshua Prupes , Chia-Wei Chou , Ilya J Finkelstein

Journal: Nat Commun

PubMed ID: 37034598

Doi: 10.1101/2023.03.27.534188

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Correlations of receptor desensitization of gain-of-function GABRB3 variants with clinical severity

Authors: Susan X N Lin, Philip K Ahring, Angelo Keramidas, Vivian W Y Liao, Rikke S Møller, Mary Chebib, Nathan L Absalom

Journal: Brain

PubMed ID: 37647766

Doi: 10.1093/brain/awad285

Products & Services: Plasmid DNA Preparation

Recombinant protein expression in proteome-reduced cells under aerobic and oxygen-limited regimes

Authors: Alvaro R Lara, Jose Utrilla, Luz María Martínez, Niels Krausch, Lucas Kaspersetz, David Hidalgo, Nicolas Cruz-Bournazou, Peter Neubauer, Juan-Carlos Sigala, Guillermo Gosset, Jochen Büchs

Journal: Biotechnol Bioeng

PubMed ID: 38178599

Doi: 10.1002/bit.28645

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9S1R nullomer peptide induces mitochondrial pathology, metabolic suppression, and enhanced immune cell infiltration, in triple-negative breast cancer mouse model

Authors: Nilufar Ali, Cody Wolf, Swarna Kanchan, Shivakumar R Veerabhadraiah, Laura Bond, Matthew W Turner, Cheryl L Jorcyk, Greg Hampikian

Journal: Biomed Pharmacother

PubMed ID: 38118350

Doi: 10.1016/j.biopha.2023.115997.

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Redox signalling regulates breast cancer metastasis via phenotypic and metabolic reprogramming due to p63 activation by HIF1α

Authors: Zuen Ren, Malindrie Dharmaratne, Huizhi Liang, Outhiriaradjou Benard, Miriam Morales-Gallego, Kimita Suyama, Viney Kumar, Atefeh Taherian Fard, Ameya S Kulkarni, Michael Prystowsky, Jessica C Mar, Larry Norton, Rachel B Hazan

Journal: Br J Cancer

PubMed ID: 38238426

Doi: 10.1038/s41416-023-02522-5

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Molecular Atlas of HER2+ Breast Cancer Cells Treated with Endogenous Ligands: Temporal Insights into Mechanisms of Trastuzumab Resistance

Authors: Kavitha Mukund, Jackelyn A Alva-Ornelas, Adam L Maddox, Divya Murali, Darya Veraksa, Andras Saftics, Jerneja Tomsic, David Frankhouser, Meagan Razo, Tijana Jovanovic-Talisman, Victoria L Seewaldt, Shankar Subramaniam

Journal: Cancers (Basel)

PubMed ID: 38339304

Doi: 10.3390/cancers16030553

Products & Services: Recombinant Proteins

Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44

Authors: Emily M Cross, Oriano Marin, Daryl Ariawan, David Aragão, Giorgio Cozza, Enzo Di Iorio, Jade K Forwood, Gualtiero Alvisi

Journal: FEBS Lett

PubMed ID: 38158756

Doi: 10.1002/1873-3468.14797

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Myosin Va-dependent Transport of NMDA Receptors in Hippocampal Neurons

Authors: Ru Gong, Linwei Qin, Linlin Chen, Ning Wang, Yifei Bao, Wei Lu

Journal: Neurosci Bull

PubMed ID: 38291290

Doi: 10.1007/s12264-023-01174-y

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Revamped mini-αA-crystallin showed improved skin permeation and therapeutic activity against melittin-induced toxicity

Authors: Tenzin Tender, Rakesh Ravishankar Rahangdale, Madhavan Nampoothiri, Ruchira Raychaudhuri, Srinivas Mutalik, Krishna Sharma, Raghu Chandrashekar H

Journal: Toxicon

PubMed ID: 38211805

Doi: 10.1016/j.toxicon.2024.107611

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Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors

Authors: Chih-Wei Chu, Tomislav Čaval, Frederico Alisson-Silva, Akshaya Tankasala, Christina Guerrier, Gregg Czerwieniec, Heinz Läubli, Flavio Schwarz

Journal: Life Sci Alliance

PubMed ID: 38176728

Doi: 10.26508/lsa.202302368

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An immunocytokine consisting of a TNFR2 agonist and TNFR2 scFv enhances the expansion of regulatory T cells through TNFR2 clustering

Authors: Masaki Inoue, Yuta Tsuji, Ayaka Kashiwada, Asahi Yokoyama, Akane Iwata, Yasuhiro Abe, Haruhiko Kamada, Shin-Ichi Tsunoda

Journal: Biochem Biophys Res Commun

PubMed ID: 38262291

Doi: 10.1016/j.bbrc.2024.149498

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Surface-modified measles vaccines encoding oligomeric, prefusion-stabilized SARS-CoV-2 spike glycoproteins boost neutralizing antibody responses to Omicron and historical variants, independent of measles seropositivity

Authors: Miguel Á Muñoz-Alía, Rebecca A Nace, Baskar Balakrishnan, Lianwen Zhang, Nandakumar Packiriswamy, Gagandeep Singh, Prajakta Warang, Ignacio Mena, Riya Narjari, Rianna Vandergaast, Kah-Whye Peng, Adolfo García-Sastre, Michael Schotsaert, Stephen J Russell

Journal: MBio

PubMed ID: 38193729

Doi: 10.1128/mbio.02928-23

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Production of recombinant HPV11/16 E6/E7-MBP-His fusion proteins and their potential to induce cytokine secretion by immune cells in peripheral blood

Authors: Mei-Nian Xu, Mei-Zhen Zhong, Si-Ning Feng, Yan-Qin Xu, Xiao-Ming Peng, Kang Zeng, Xiao-Wen Huang

Journal: Virol J

PubMed ID: 38183109

Doi: 10.1186/s12985-023-02281-y

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Development of Moloney Murine Leukemia Virus Reverse Transcriptase Fused with Archaeal DNA-binding Protein Sis7a

Authors: Goldyna M Simanjuntak, Azzania Fibriani, Amalia A Fananda, Nicholas Yamahoki

Journal: Recent Pat Biotechnol

PubMed ID: 37016518

Doi: 10.2174/1872208317666230403104302

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DOCK4 is a Novel Prognostic Biomarker and Correlated with Immune Infiltrates in Colon Adenocarcinoma

Authors: Xingjiang Xie, Yi Lu, Bo Wang, Xiaobin Yin, Jianfeng Chen

Journal: Comb Chem High Throughput Screen

PubMed ID: 37702239

Doi: 10.2174/1386207326666230912094101

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Inactivation mechanism of cold plasma combined with 222 nm ultraviolet for spike protein and its application in disinfecting of SARS-CoV-2

Authors: Xiaowei Sheng, Jin Wang, Luling Zhao, Wenjing Yan, Jing Qian, Zhaobin Wang, Jianhao Zhang, Vijaya Raghavan

Journal: J Hazard Mater

PubMed ID: 38215522

Doi: 10.1016/j.jhazmat.2024.133458

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IL13Rα2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathway

Authors: Weifeng Xu, Rui Chao, Xinru Xie, Yi Mao, Xinwei Chen, Xuzhuo Chen, Shanyong Zhang

Journal: Cell Commun Signal

PubMed ID: 38291404

Doi: 10.1186/s12964-023-01423-7

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Cross-species immunoprotective antigens (subolesin, ferritin 2 and P0) provide protection against Rhipicephalus sanguineus sensu lato

Authors: Ismail Zeb, Luís Fernando Parizi, Muhammad Israr, Itabajara da Silva Vaz, Abid Ali

Journal: Parasit Vectors

PubMed ID: 38172894

Doi: 10.1186/s13071-023-06079-3

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Deciphering the crystal structure of a novel nanobody against the NEIL1 DNA glycosylase

Authors: Marlo K Thompson, Nidhi Sharma, Andrea Thorn, Aishwarya Prakash

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 38289715

Doi: 10.1107/S205979832400038X

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Nanobodies as potential tools for microbiological testing of live biotherapeutic products

Authors: Robert J Dorosky, Jeremy E Schreier, Stephanie L Lola, Rosa L Sava, Michael P Coryell, Adovi Akue, Mark KuKuruga, Paul E Carlson, Sheila M Dreher-Lesnick, Scott Stibitz

Journal: AMB Express

PubMed ID: 38245586

Doi: 10.1186/s13568-023-01659-z

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Oral delivery of bacteria expressing wsv108 gene-specific dsRNA protects shrimp from white spot syndrome virus (WSSV) infection

Authors: Linwei Yang, Siyou Huang, Zi-Ang Wang, Deyu Han, Yushi Gan, Ran Geng, Hongliang Zuo, Zhixun Guo, Shaoping Weng, Jianguo He, Xiaopeng Xu

Journal: Int J Biol Macromol

PubMed ID: 38302014

Doi: 10.1016/j.ijbiomac.2024.129840

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Longitudinal analysis of antibody responses to Plasmodium vivax sporozoite antigens following natural infection

Authors: Pongsakorn Thawornpan, Justin Nicholas, Chayapat Malee, Piyawan Kochayoo, Kittikorn Wangriatisak, Pachara Tianpothong, Francis Babila Ntumngia, Samantha J Barnes, John H Adams, Patchanee Chootong

Journal: PLoS Negl Trop Dis

PubMed ID: 38277340

Doi: 10.1371/journal.pntd.0011907

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Identification and Functional Characterization of Oxidosqualene Cyclases from Medicinal Plant

Authors: Iffat Parveen, Mei Wang, Joseph Lee, Jianping Zhao, Yingjie Zhu, Amar G Chittiboyina, Ikhlas A Khan, Zhiqiang Pan

Journal: Plants (Basel)

PubMed ID: 38256784

Doi: 10.3390/plants13020231

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A dual-functional oncolytic adenovirus ZD55-aPD-L1 scFv armed with PD-L1 inhibitor potentiates its antitumor activity

Authors: Shengsheng Mei, Shanshan Peng, Eu Gene Vong, Jinbiao Zhan

Journal: Int Immunopharmacol

PubMed ID: 38278066

Doi: 10.1016/j.intimp.2024.111579

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Mulberry-derived miR168a downregulates BmMthl1 to promote physical development and fecundity in silkworms

Authors: Lin Chen, Jiubo Liang, Qi Zhang, Chao Yang, Hulin Lu, Renze Zhang, Kaiying Chen, Sheng Wang, Mingbo Li, Shaoyu Zhang, Ningjia He

Journal: Int J Biol Macromol

PubMed ID: 38199542

Doi: 10.1016/j.ijbiomac.2023.129077

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Individual transmembrane domains of SfABCC2 from Spodoptera frugiperda do not serve as functional Cry1F receptors

Authors: Jianfeng Zhong, Rafael Ferreira Dos Santos, Heba Abdelgaffar, Caroline Placidi de Bortoli, Ahmad Raza, Juan Luis Jurat-Fuentes

Journal: Pestic Biochem Physiol

PubMed ID: 38458684

Doi: 10.1016/j.pestbp.2024.105777

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A novel fully human anti-NT-ANGPTL3 antibody from phage display library exhibits potent ApoB, TG, and LDL-C lowering activities in hyperlipidemia mice

Authors: Panpan Zhang, Ke Wang, Tuo Hu, Menglong Xu, Xiangyan You, Manman Chen, Xuan Tang, Huajing Hu, Yiwei Jiang, Wenfeng Zhao, Shuhua Tan

Journal: FASEB J

PubMed ID: 38174870

Doi: 10.1096/fj.202301564RR

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Multivalent Calixarene Complexation of a Designed Pentameric Lectin

Authors: Ronan J Flood, Linda Cerofolini, Marco Fragai, Peter B Crowley

Journal: Biomacromolecules

PubMed ID: 38227741

Doi: 10.1021/acs.biomac.3c01280

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Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23

Authors: Yehudi Bloch, Jan Felix, Romain Merceron, Mathias Provost, Royan Alipour Symakani, Robin De Backer, Elisabeth Lambert, Ahmad R Mehdipour, Savvas N Savvides

Journal: Nat Struct Mol Biol

PubMed ID: 38287195

Doi: 10.1038/s41594-023-01190-6

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Temporal dynamics of the early immune response following Mycobacterium bovis infection of cattle

Authors: Thomas Holder, Sreenidhi Srinivasan, Adrian McGoldrick, Gareth A Williams, Simonette Palmer, John Clarke, Amanda O'Brien, Andrew J K Conlan, Nick Juleff, H Martin Vordermeier, Gareth J Jones, Vivek Kapur

Journal: Sci Rep

PubMed ID: 38297023

Doi: 10.1038/s41598-024-52314-x

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ADORA2B, transcriptionally suppressing by MYC, promotes ferroptosis of chondrocytes via inhibition of the PI3K/Akt pathway in mice with osteoarthritis

Authors: Shen Li, Jiangbo Han, Jiongzhe Cao, Hong Han, Bin Lu, Tao Wen, Weiguo Bian

Journal: Environ Toxicol

PubMed ID: 38174997

Doi: 10.1002/tox.24131

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High-titer manufacturing of SARS-CoV-2 Spike-pseudotyped VSV in stirred-tank bioreactors

Authors: Hayley M Todesco, Chris Gafuik, Cini M John, Erin L Roberts, Breanna S Borys, Alexis Pawluk, Michael S Kallos, Kyle G Potts, Douglas J Mahoney

Journal: Mol Ther Methods Clin Dev

PubMed ID: 38327804

Doi: 10.1016/j.omtm.2024.101189

Improved Solubility and Stability of a Thermostable Carbonic Anhydrase via Fusion with Marine-Derived Intrinsically Disordered Solubility Enhancers

Authors:

Journal: Int J Mol Sci

PubMed ID: 38256209

Doi: 10.3390/ijms25021139

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TLR4 Ligands in Typhoid Vi Polysaccharide Subunit Vaccines Contribute to Immunogenicity

Authors:

Journal: Immunohorizons

PubMed ID: 38180344

Doi: 10.4049/immunohorizons.2300085

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Dual-specificity phosphatase 1 interacts with prohibitin 2 to improve mitochondrial quality control against type-3 cardiorenal syndrome

Authors: Nanyang Liu, Yanqiu Ding, Hao Zhou, Xing Chang, Long Lou

Journal: Int J Med Sci

PubMed ID: 38322592

Doi: 10.7150/ijms.90484

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Targeted mutagenesis in mice via an engineered AsCas12f1 system

Authors: Peng Fan, Hejun Wang, Feiyu Zhao, Tao Zhang, Jinze Li, Xiaodi Sun, Yongduo Yu, Haoyang Xiong, Liangxue Lai, Tingting Sui

Journal: Cell Mol Life Sci

PubMed ID: 38280977

Doi: 10.1007/s00018-023-05100-3

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A feedback loop that drives cell death and proliferation and its defect in intestinal stem cells

Authors: Shivakshi Sulekh, Yuko Ikegawa, Saki Naito, Asami Oji, Ichiro Hiratani, Sa Kan Yoo

Journal: Life Sci Alliance

PubMed ID: 38296349

Doi: 10.26508/lsa.202302238

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Clinical assays rapidly predict bacterial susceptibility to monoclonal antibody therapy

Authors: Matthew J Slarve, Neven Bowler, Elizabeth Burk, Jun Yan, Ulrike Carlino-MacDonald, Thomas A Russo, Brian M Luna, Brad Spellberg

Journal: JCI Insight

PubMed ID: 38258902

Doi: 10.1172/jci.insight.174799

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B-Type Natriuretic Peptide Inhibits the Expression and Function of SERCA2a in Heart Failure

Authors: Yuting Zhai, Junhong Chen, Rongsheng Kan, Haochen Xuan, Chaofan Wang, Dongye Li, Tongda Xu

Journal: Int Heart J

PubMed ID: 38556337

Doi: 10.1536/ihj.23-144

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Design of protein-binding peptides with controlled binding affinity: the case of SARS-CoV-2 receptor binding domain and angiotensin-converting enzyme 2 derived peptides

Authors: Giacomo Parisi, Roberta Piacentini, Alessio Incocciati, Alessandra Bonamore, Alberto Macone, Jakob Rupert, Elsa Zacco, Mattia Miotto, Edoardo Milanetti, Gian Gaetano Tartaglia, Giancarlo Ruocco, Alberto Boffi, Lorenzo Di Rienzo

Journal: Front Mol Biosci

PubMed ID: 38250735

Doi: 10.3389/fmolb.2023.1332359

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Proteome profiling of enriched membrane-associated proteins unraveled a novel sophorose and cello-oligosaccharide transporter in Trichoderma reesei

Authors: Karoline Maria Vieira Nogueira, Vanessa Mendes, Karthik Shantharam Kamath, Anusha Cheruku, Letícia Harumi Oshiquiri, Renato Graciano de Paula, Claudia Carraro, Wellington Ramos Pedersoli, Lucas Matheus Soares Pereira, Luiz Carlos Vieira, Andrei Stecca Steindorff, Ardeshir Amirkhani, Matthew J McKay, Helena Nevalainen, Mark P Molloy, Roberto N Silva

Journal: Microb Cell Fact

PubMed ID: 38229067

Doi: 10.1186/s12934-023-02279-9

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Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

Authors: Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Sijie Yang, Xiao Niu, Tianhe Xiao, Jing Wang , Lijuan Zhao, Haiyan Sun, Ran An, Na Zhang, Yao Wang, Peng Wang, Lingling Yu, Zhe Lv, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Xiaoliang Sunney Xie, Youchun Wang, Yunlong Cao

Journal: Nature

PubMed ID: 37993710

Doi: 10.1038/s41586-023-06753-7

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Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules

Authors: Christopher M. Hickey, Katherine M. Digianantonio, Kurt Zimmermann , Alicia Harbin, Connor Quinn, Avani Patel, Peter Gareiss , Amanda Chapman1 , Bernadette Tiberi1,2, Jennifer Dobrodziej1,3, John Corradi1 , Angela M. Cacace1 , David R. Langley & Miklós Békés

Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY

Doi: 10.1038/s41594-023-01146-w

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Influenza a Neuraminidase-Based Bivalent mRNA Vaccine Induces Th1-Type Immune Response and Provides Protective Effects in Mice

Authors: Mingyang Li , Mengyuan Liu , Shaohui Song, Ruirui Zhao, Yun Xie, Jing Liu, Lilan Xu, Xuefeng Ma, Mingyu Song, Jian Zhou and Guoyang Liao

Journal: Vaccine

Doi: 10.3390/vaccines12030300

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The CRISPR effector Cam1 mediates membrane depolarization for phage defence

Authors: Christian F. Baca, You Yu, Jakob T. Rostøl, Puja Majumder, Dinshaw J. Patel & Luciano A. Marraffini

Journal: Nature

PubMed ID: 38200316

Doi: 10.1038/s41586-023-06902-y

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PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends

Authors: Nagaraja Chappidi 1, Thomas Quail 2, Simon Doll 3, Laura T Vogel 4, Radoslav Aleksandrov 5, Suren Felekyan 4, Ralf Kühnemuth 4, Stoyno Stoynov 5, Claus A M Seidel 4, Jan Brugués 6, Marcus Jahnel 3, Titus M Franzmann 1, Simon Alberti

Journal: Cell

PubMed ID: 38320550

Doi: 10.1016/j.cell.2024.01.015

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Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria

Authors: Sabine Poerschke, Silke Oeljeklaus, Luis Daniel Cruz-Zaragoza, Alexander Schenzielorz, Drishan Dahal, Hauke Sven Hillen, Hirak Das, Laura Sophie Kremer, Anusha Valpadashi, Mirjam Breuer, Johannes Sattmann, Ricarda Richter-Dennerlein, Bettina Warscheid, Sven Dennerlein, Peter Rehling

Journal: Cell

PubMed ID: 38199007

Doi: 10.1016/j.molcel.2023.12.013

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Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification

Authors: Jun Wang , Jinyong Huang , Yunlong Hu , Qianwen Guo , Shasha Zhang , Jinglin Tian , Yanqin Niu , Ling Ji , Yuzhong Xu , Peijun Tang , Yaqin He , Yuna Wang , Shuya Zhang , Hao Yang , Kang Kang , Xinchun Chen , Xinying Li , Ming Yang , Deming Gou

Journal: Nat Commun

PubMed ID: 38168054

Doi: 10.1038/s41467-023-44461-y

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Leafhopper salivary vitellogenin mediates virus transmission to plant phloem

Authors: Yanfei Wang , Chengcong Lu , Shude Guo , Yuxin Guo , Taiyun Wei , Qian Chen

Journal: Nat Commun

PubMed ID: 38167823

Doi: 10.1038/s41467-023-43488-5

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Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use

Authors: Anna Worthmann , Julius Ridder , Sharlaine Y L Piel , Ioannis Evangelakos , Melina Musfeldt , Hannah Voß , Marie O'Farrell , Alexander W Fischer , Sangeeta Adak , Monica Sundd , Hasibullah Siffeti , Friederike Haumann , Katja Kloth , Tatjana Bierhals , Markus Heine , Paul Pertzborn , Mira Pauly , Julia-Josefine Scholz , Suman Kundu , Marceline M Fuh , Axel Neu , Klaus Tödter , Maja Hempel , Uwe Knippschild , Clay F Semenkovich , Hartmut Schlüter , Joerg Heeren , Ludger Scheja , Christian Kubisch , Christian Schlein

Journal: Nat Commun

PubMed ID: 38167725

Doi: 10.1038/s41467-023-44364-y

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Rif2 interaction with Rad50 counteracts Tel1 functions in checkpoint signalling and DNA tethering by releasing Tel1 from MRX binding

Authors: Paolo Pizzul, Erika Casari, Carlo Rinaldi, Marco Gnugnoli, Marco Mangiagalli, Renata Tisi, Maria Pia Longhese

Journal: Nucleic Acids Res

PubMed ID: 38180815

Doi: 10.1093/nar/gkad1246

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LATS2 condensates organize signalosomes for Hippo pathway signal transduction

Authors: Min Qin, Ershuo Geng, Jingning Wang, Man Yu, Tianqi Dong, Shasha Li, Xiao Zhang, Jiaming Lin, Mingjun Shi, Juebei Li, Huixia Zhang, Lian Chen, Xiaolei Cao, Liu Huang, Mingwei Wang, Yan Li, Xiang-ping Yang, Bin Zhao & Shuguo Sun

Journal: Nature Chemical Biology

PubMed ID: 38200110

Doi: 10.1038/s41589-023-01516-x

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Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs

Authors: Yingli Zhu, Thibaut Burg, Katrien Neyrinck, Tim Vervliet, Fatemeharefeh Nami, Ellen Vervoort, Karan Ahuja, Maria Livia Sassano, Yoke Chin Chai, Arun Kumar Tharkeshwar, Jonathan De Smedt, Haibo Hu, Geert Bultynck, Patrizia Agostinis, Johannes V. Swinnen, Ludo Van Den Bosch, Rodrigo Furtado Madeiro da Costa & Catherine Verfaillie

Journal: Acta Neuropathologica

PubMed ID: 38395965

Doi: 10.1007/s00401-023-02666-x

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A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease

Authors: Su-Jeong Kim, Brendan Miller, Nicolas G Hartel, Ricardo Ramirez, Regina Gonzalez Braniff, Naphada Leelaprachakul, Amy Huang, Yuzhu Wang, Thalida Em Arpawong, Eileen M Crimmins, Penglong Wang, Xianbang Sun, Chunyu Liu, Daniel Levy, Kelvin Yen, Giselle M Petzinger, Nicholas A Graham, Michael W Jakowec, Pinchas Cohen

Journal: Mol Psychiatry

PubMed ID: 38167865

Doi: 10.1038/s41380-023-02344-0

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Cdk5-dependent rapid formation and stabilization of dendritic spines by corticotropin-releasing factor

Authors: Dorien Vandael, Katlijn Vints, Pieter Baatsen, Małgorzata A Śliwińska, Sergio Gabarre, Lies De Groef, Lieve Moons, Vasily Rybakin, Natalia V Gounko

Journal: Transl Psychiatry

PubMed ID: 38233378

Doi: 10.1038/s41398-024-02749-7

Profiling the Plasmodium falciparum Erythrocyte Membrane Protein 1-Specific Immununoglobulin G Response Among Ghanaian Children With Hemoglobin S and C

Authors: Andrew V Oleinikov, Zakaria Seidu, Irina V Oleinikov, Mary Tetteh, Helena Lamptey, Michael F Ofori, Lars Hviid, Mary Lopez-Perez

Journal: J Infect Dis

PubMed ID: 37804095

Doi: 10.1093/infdis/jiad438

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The structure of the diheme cytochrome c from Neisseria gonorrhoeae reveals multiple contributors to tuning reduction potentials

Authors: Fangfang Zhong, Morgan E Reik, Michael J Ragusa, Ekaterina V Pletneva

Journal: J Inorg Biochem

PubMed ID: 38330683

Doi: 10.1016/j.jinorgbio.2024.112496

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Systematic analysis of the prognostic value and immunological function of LTBR in human cancer

Authors: Yinteng Wu, Shijian Zhao, Wenliang Guo, Ying Liu, Marìa Del Mar Requena Mullor, Raquel Alarcòn Rodrìguez, Ruqiong Wei

Journal: Aging (Albany NY)

PubMed ID: 38175686

Doi: 10.18632/aging.205356

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Three immunizations with Novavax's protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2

Authors: Klara Lenart, Rodrigo Arcoverde Cerveira, Fredrika Hellgren, Sebastian Ols, Daniel J Sheward, Changil Kim, Alberto Cagigi, Matthew Gagne, Brandon Davis, Daritza Germosen, Vicky Roy, Galit Alter, Hélène Letscher, Jérôme Van Wassenhove, Wesley Gros, Anne-Sophie Gallouët, Roger Le Grand, Harry Kleanthous, Mimi Guebre-Xabier, Ben Murrell, Nita Patel, Gregory Glenn, Gale Smith, Karin Loré

Journal: npj Vaccines

PubMed ID: 38245545

Doi: 10.1038/s41541-024-00806-2

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Disease-associated polyalanine expansion mutations impair UBA6-dependent ubiquitination

Authors: Fatima Amer-Sarsour, Daniel Falik, Yevgeny Berdichevsky, Alina Kordonsky, Sharbel Eid, Tatiana Rabinski, Hasan Ishtayeh, Stav Cohen-Adiv, Itzhak Braverman, Sergiu C Blumen, Tal Laviv, Gali Prag, Gad D Vatine, Avraham Ashkenazi

Journal: EMBO J

PubMed ID: 38177505

Doi: 10.1038/s44318-023-00018-9

A lncRNA Dleu2-encoded peptide relieves autoimmunity by facilitating Smad3-mediated Treg induction

Authors: Sibei Tang, Junxun Zhang, Fangzhou Lou, Hong Zhou, Xiaojie Cai, Zhikai Wang, Libo Sun, Yang Sun, Xiangxiao Li, Li Fan, Yan Li, Xinping Jin, Siyu Deng, Qianqian Yin, Jing Bai, Hong Wang, Honglin Wang

Journal: EMBO Rep

PubMed ID: 38291338

Doi: 10.1038/s44319-024-00070-4

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Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

Authors: Solene Masloh, Anne Chevrel, Maxime Culot, Anaëlle Perrocheau, Yogeshvar N Kalia, Samuel Frehel, Rémi Gaussin, Fabien Gosselet, Simon Huet, Magali Zeisser Labouebe, Leonardo Scapozza

Journal: Pharmaceutics

PubMed ID: 38258126

Doi: 10.3390/pharmaceutics16010116

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The Chinese Hamster Ovary Cell-Based H9 HA Subunit Avian Influenza Vaccine Provides Complete Protection against the H9N2 Virus Challenge in Chickens

Authors: Shunfan Zhu, Zhenyu Nie, Ying Che, Jianhong Shu, Sufang Wu, Yulong He, Youqiang Wu, Hong Qian, Huapeng Feng, Qiang Zhang

Journal: Viruses

PubMed ID: 38275973

Doi: 10.3390/v16010163

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A fast and easy one-step purification strategy for plant-made antibodies using Protein A magnetic beads

Authors: Loïc Faye, Clemens Grünwald-Gruber, Louis-Philippe Vezina, Véronique Gomord, Bertrand Morel

Journal: Front Plant Sci

PubMed ID: 38235198

Doi: 10.3389/fpls.2023.1276148

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Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain

Authors: Michele Monti, Edoardo Milanetti, Myrthe T Frans, Mattia Miotto, Lorenzo Di Rienzo, Maksim V Baranov, Giorgio Gosti, Arun Kumar Somavarapu, Madhu Nagaraj, Thaddeus W Golbek, Emiel Rossing, Sam J Moons, Thomas J Boltje, Geert van den Bogaart, Tobias Weidner, Daniel E Otzen, Gian Gaetano Tartaglia, Giancarlo Ruocco, Steven J Roeters

Journal: J Phys Chem B

PubMed ID: 38190651

Doi: 10.1021/acs.jpcb.3c06258

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Complete microbial synthesis of crocetin and crocins from glycerol in Escherichia coli

Authors: Jun Ho Lee, Seong-Rae Lee, Sang Yup Lee, Pyung Cheon Lee

Journal: Microb Cell Fact

PubMed ID: 38178149

Doi: 10.1186/s12934-023-02287-9

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Restricted Omicron-specific cross-variant memory B-cell immunity after a 3rd dose/booster of monovalent Wuhan-Hu-1-containing COVID-19 mRNA vaccine

Authors: Iana H Haralambieva, Jonathon M Monroe, Inna G Ovsyannikova, Nathaniel D Warner, Diane E Grill, Gregory A Poland, Richard B Kennedy

Journal: Vaccine

PubMed ID: 38233288

Doi: 10.1016/j.vaccine.2024.01.032

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Structure of a tripartite protein complex that targets toxins to the type VII secretion system

Authors: Timothy A Klein, Prakhar Y Shah, Polyniki Gkragkopoulou, Dirk W Grebenc, Youngchang Kim, John C Whitney

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38194450

Doi: 10.1073/pnas.2312455121

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Orthopoxvirus-Specific T-Cell Responses in Convalescent Mpox Patients

Authors: Caroline C Traut, Joyce L Jones, Renata A Sanders, Laura R Clark, Matthew M Hamill, Georgia Stavrakis, Joel Sop, Tyler P Beckey, Sara C Keller, Elizabeth A Gilliams, Willa V Cochran, Oliver Laeyendecker, Yukari C Manabe, Heba H Mostafa, David L Thomas, Bhakti Hansoti, Kelly A Gebo, Joel N Blankson

Journal: J Infect Dis

PubMed ID: 37380166

Doi: 10.1093/infdis/jiad245

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Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury

Authors: Ari Kwon, Na Young Lee, Jae-Hyun Yu, Myeung Gi Choi, Jeongwoo Park, Ja Hyun Koo

Journal: Cell Death Dis

PubMed ID: 38225223

Doi: 10.1038/s41419-024-06448-5

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