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CD38-Specific CAR Integrated into CD38 Locus Driven by Different Promoters Causes Distinct Antitumor Activities of T and NK Cells
Authors: Chan Liao, Yajie Wang, Yanjie Huang, Yanting Duan, Yan Liang, Jiangqing Chen, Jie Jiang, Kai Shang, Chun Zhou, Ying Gu, Nan Liu, Xun Zeng, Xiaofei Gao, Yongmin Tang, Jie Sun
Journal: Adv Sci (Weinh)
PubMed ID: 37485647
Doi: 10.1002/advs.202207394
The Effect of Long-Term Passage on Porcine SMCs' Function and the Improvement of TGF-β1 on Porcine SMCs' Secretory Function in Late Passage
Authors: Yan-Yan Zheng, Ze-Nan Hu, Zheng Liu, Yi-Chen Jiang, Ren-Peng Guo, Shi-Jie Ding, Guang-Hong Zhou
Journal: Foods
PubMed ID: 37509774
Doi: 10.3390/foods12142682
Products & Services: Molecular Biology Reagents   
Creation of a Peptide Antagonist of the GFRAL-RET Receptor Complex for the Treatment of GDF15-Induced Malaise
Authors: Tito Borner, Ian C Tinsley, Brandon T Milliken, Sarah A Doebley, Nicholas R Najjar, Deborah J Kerwood, Bart C De Jonghe, Matthew R Hayes, Robert P Doyle
Journal: J Med Chem
PubMed ID: 37506293
Doi: 10.1021/acs.jmedchem.3c00667
Products & Services: Molecular Biology Reagents   
Hierarchical design of pseudosymmetric protein nanoparticles
Authors: Quinton M Dowling, Young-Jun Park, Neil Gerstenmaier, Erin C Yang, Adam Wargacki, Yang Hsia, Chelsea N Fries, Rashmi Ravichandran, Carl Walkey, Anika Burrell, David Veesler, David Baker, Neil P King
Journal: Res Sq
PubMed ID: 37503272
Doi: 10.21203/rs.3.rs-3074553/v1
Products & Services: Molecular Biology Reagents   
Structural and Kinetic Characterization of the SpeG Spermidine/Spermine -acetyltransferase from Methicillin-Resistant USA300
Authors: Sofiya Tsimbalyuk, Aleksander Shornikov, Parul Srivastava, Van Thi Bich Le, Imani Warren, Yogesh B Khandokar, Misty L Kuhn, Jade K Forwood
Journal: Cells
PubMed ID: 37508494
Doi: 10.3390/cells12141829
Products & Services: Recombinant Antibody Expression   
Mapping of corticotropin-releasing factor, receptors, and binding protein mRNA in the chicken telencephalon throughout development
Authors: Alek H Metwalli, Alessandra Pross, Ester Desfilis, Antonio Abellán, Loreta Medina
Journal: J Comp Neurol
PubMed ID: 37393534
Doi: 10.1002/cne.25517
Products & Services: PCR Cloning and Subcloning   
Polyphenol Oxidase Products Are Priming Agents for LPMO Peroxygenase Activity
Authors: Caio de Oliveira Gorgulho Silva, Marlene Vuillemin, Mirjam A Kabel, Willem J H van Berkel, Anne S Meyer, Jane W Agger
Journal: ChemSusChem
PubMed ID: 37278305
Doi: 10.1002/cssc.202300559
Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry
Authors: Susan A Leonhardt, Michael D Purdy, Jonathan R Grover, Ziwei Yang, Sandra Poulos, William E McIntire, Elizabeth A Tatham, Satchal K Erramilli, Kamil Nosol, Kin Kui Lai, Shilei Ding, Maolin Lu, Pradeep D Uchil, Andrés Finzi, Alan Rein, Anthony A Kossiakoff, Walther Mothes, Mark Yeager
Journal: Nat Commun
PubMed ID: 37474505
Doi: 10.1038/s41467-023-39262-2
Products & Services: Gene Synthesis   
Actions of a Novel Bacterial Topoisomerase Inhibitor against Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks
Authors: Soziema E Dauda, Jessica A Collins, Jo Ann W Byl, Yanran Lu, Jack C Yalowich, Mark J Mitton-Fry, Neil Osheroff
Journal: Int J Mol Sci
PubMed ID: 37569485
Doi: 10.3390/ijms241512107
Accurate identification and discrimination of serovar Gallinarum biovars Gallinarum and Pullorum by a multiplex PCR based on the new genes of and
Authors: Li Song, Ruimeng Tan, Dan Xiong, Xinan Jiao, Zhiming Pan
Journal: Front Vet Sci
PubMed ID: 37476820
Doi: 10.3389/fvets.2023.1220118
Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor
Authors: Wan Ni Chia, Chee Wah Tan, Aaron Wai Kit Tan, Barnaby Young, Tyler N Starr, Ester Lopez, Guntur Fibriansah, Jennifer Barr, Samuel Cheng, Aileen Ying-Yan Yeoh, Wee Chee Yap, Beng Lee Lim, Thiam-Seng Ng, Wan Rong Sia, Feng Zhu, Shiwei Chen, Jinyan Zhang, Madeline Sheng Si Kwek, Allison J Greaney, Mark Chen, Gough G Au, Prasad N Paradkar, Malik Peiris, Amy W Chung, Jesse D Bloom, David Lye, Sheemei Lok, Lin-Fa Wang
Journal: Sci Adv
PubMed ID: 37494438
Doi: 10.1126/sciadv.ade3470
Computationally Designed Small Molecules Disassemble Both Soluble Oligomers and Protofibrils of Amyloid β-Protein Responsible for Alzheimer's Disease
Authors: Yingying Jin, Matthew A Downey, Ambuj Singh, Steven K Buratto, Michael T Bowers
Journal: ACS Chem Neurosci
PubMed ID: 37442126
Doi: 10.1021/acschemneuro.3c00266
Absolute Quantification of Photoreceptor Outer Segment Proteins
Authors: Nikolai P Skiba, Tylor R Lewis, William J Spencer, Carson M Castillo, Andrej Shevchenko, Vadim Y Arshavsky
Journal: J Proteome Res
PubMed ID: 37493966
Doi: 10.1021/acs.jproteome.3c00267
Products & Services: Peptide Synthesis   
Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues
Authors: Yorick Post, Archana Dilip, Liqin Xie, Asmiti Sura, Nicholas Suen, Jay Ye, Devin Mutha, Angela T Liu, Huy Nguyen, Elizabeth Whisler, Darshini Shah, Shalaka Deshmukh, Navrose Dhaliwal, Ben Bauer, Eskedar Nigatu, Anh Diep, Tom Lopez, Tristan W Fowler, Sung-Jin Lee, Chenggang Lu, Wen-Chen Yeh, Hui Chen, Yang Li
Journal: Cell Chem Biol
PubMed ID: 37413985
Doi: 10.1016/j.chembiol.2023.06.006
Products & Services: Gene Synthesis   
Biomimetic Mineralized CRISPR/Cas RNA Nanoparticles forEfficient Tumor-Specific Multiplex Gene Editing
Authors: Yan Liang , Jingge Zhang , Chenlu Xu , Jinjin Wang , Wenshuai Han , Jiali Yang , Sixuan Wu , Jingyi An , Junjie Liu , Zhenzhong Zhang , Jinjin Shi , Kaixiang Zhang
Journal: ACS Nano .
PubMed ID: 37481734
Doi: 10.1021/acsnano.3c04116
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Nanoengineered mesenchymal stem cell therapy for pulmonary fibrosis in young and aged mice
Authors: Meng-Meng Han , Xing-Yue He , Ling Tang , Liang Qi , Ming-Yuan Yang , Yi Wang , Lei Xing , Jee-Heon Jeong , Hu-Lin Jiang
Journal: Sci Adv .
PubMed ID: 37467328
Doi: 10.1126/sciadv.adg5358
Products & Services: Recombinant Proteins   
Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses
Authors: Xiuyuan Ou , Ge Xu , Pei Li , Yan Liu , Fuwen Zan , Pan Liu , Jiaxin Hu , Xing Lu , Siwen Dong , Yao Zhou , Zhixia Mu , Zhiqiang Wu , Jianwei Wang , Qi Jin , Pinghuang Liu , Jian Lu , Xiangxi Wang , Zhaohui Qian
Journal: Cell Discov .
PubMed ID: 37507385
Doi: 10.1038/s41421-023-00581-9
Products & Services: Gene Synthesis   
Targeting the Spike Receptor Binding Domain Class V Cryptic Epitope by an Antibody with Pan-Sarbecovirus Activity
Authors: Jaime L Jensen, Rajeshwer S Sankhala, Vincent Dussupt, Hongjun Bai, Agnes Hajduczki, Kerri G Lal, William C Chang, Elizabeth J Martinez, Caroline E Peterson, Emily S Golub, Phyllis A Rees, Letzibeth Mendez-Rivera, Michelle Zemil, Erin Kavusak, Sandra V Mayer, Lindsay Wieczorek, Shruthi Kannan, Benjamin J Doranz, Edgar Davidson, Eun Sung Yang, Yi Zhang, Man Chen, Misook Choe, Lingshu Wang, Gregory D Gromowski, Richard A Koup, Nelson L Michael, Victoria R Polonis, Morgane Rolland, Kayvon Modjarrad, Shelly J Krebs, M Gordon Joyce
Journal: J Virol
PubMed ID: 37395646
Doi: 10.1128/jvi.01596-22
Products & Services: Gene Synthesis   
Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes
Authors: Shaun K Bremner, Rebecca Berends, Alexandra Kaupisch, Jennifer Roccisana, Calum Sutherland, Nia J Bryant, Gwyn W Gould
Journal: PeerJ
PubMed ID: 37520260
Doi: 10.7717/peerj.15630
A natural gene drive system confers reproductive isolation in rice
Authors: Chaolong Wang, Jian Wang, Jiayu Lu, Yehui Xiong, Zhigang Zhao, Xiaowen Yu, Xiaoming Zheng, Jing Li, Qibing Lin, Yulong Ren, Yang Hu, Xiaodong He, Chao Li, Yonglun Zeng, Rong Miao, Mali Guo, Bosen Zhang, Ying Zhu, Yunhui Zhang, Weijie Tang, Yunlong Wang, Benyuan Hao, Qiming Wang, Siqi Cheng, Xiaojuan He, Bowen Yao, Junwen Gao, Xufei Zhu, Hao Yu, Yong Wang, Yan Sun, Chunlei Zhou, Hui Dong, Xiaoding Ma, Xiuping Guo, Xi Liu, Yunlu Tian, Shijia Liu, Chunming Wang, Zhijun Cheng, Ling Jiang, Jiawu Zhou, Huishan Guo, Liwen Jiang, Dayun Tao, Jijie Chai, Wei Zhang, Haiyang Wang, Chuanyin Wu, Jianmin Wan
Journal: Cell
PubMed ID: 37499659
Doi: 10.1016/j.cell.2023.06.023
A mass spectrometry assay for detection of endogenous and lentiviral engineered hemoglobin in cultured cells and sickle cell disease mice
Authors: Xuejun Wang, William M McKillop, Theresa A Dlugi, Mary L Faber, Juliana Alvarez-Argote, Christopher B Chambers, Andrew Wilber, Jeffrey A Medin
Journal: J Gene Med
PubMed ID: 37455676
Doi: 10.1002/jgm.3567
Products & Services: Peptide Synthesis   
Kinetic and Structural Characterization of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors
Authors: Kayla Glockzin, Kathleen M Meneely, Ryan Hughes, Sean W Maatouk, Grace E Piña, Kajitha Suthagar, Keith Clinch, Joshua N Buckler, Audrey L Lamb, Peter C Tyler, Thomas D Meek, Ardala Katzfuss
Journal: Biochemistry
PubMed ID: 37418678
Doi: 10.1021/acs.biochem.3c00116
Histone deacetylase III interactions with BK polyomavirus large tumor antigen may affect protein stability
Authors: Yueh-Han Hsu, Chun-Nun Chao, Hsin-Yi Huang, Pei-Wen Zhao, Pang-Hung Hsu, Cheng-Huang Shen, San-Yuan Chen, Chiung-Yao Fang
Journal: Virol J
PubMed ID: 37464367
Doi: 10.1186/s12985-023-02128-6
Products & Services: Molecular Biology Reagents   
Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity
Authors: Ian N Boys, Alex G Johnson, Meghan R Quinlan, Philip J Kranzusch, Nels C Elde
Journal: Cell Rep
PubMed ID: 37494187
Doi: 10.1016/j.celrep.2023.112878
Products & Services: Molecular Biology Reagents   
TP5: A Novel Therapeutic Approach Targeting Aberrant and Hyperactive CDK5/p25 for the Treatment of Colorectal Carcinoma
Authors: Niranjana Amin, Herui Wang, Qi Song, Manju Bhaskar, Sharda Prasad Yadav, Mark R Gilbert, Harish Pant, Emeline Tabouret, Zhengping Zhuang
Journal: Int J Mol Sci
PubMed ID: 37511490
Doi: 10.3390/ijms241411733
Products & Services: Peptide Synthesis   
Non-canonical function of folate/folate receptor 1 during neural tube formation
Authors: Olga A Balashova, Alexios A Panoutsopoulos, Olesya Visina, Jacob Selhub, Paul S Knoepfler, Laura N Borodinsky
Journal: biorxiv
PubMed ID: 37503108
Doi: 10.1101/2023.07.19.549718
Products & Services: Catalog Peptides   
Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis
Authors: Yi Zhou, Guofei Cui, Hongwei Xu, Joanne Chun, Doris Yang, Zheng Zhang, Lihui Yang, Jingxiao Wang, Meijuan Wan, Diego F Calvisi, Shumei Lin, Xin Chen, Haichuan Wang
Journal: Cell Death Dis
PubMed ID: 37500626
Doi: 10.1038/s41419-023-05958-y
Products & Services: Catalog Peptides   
A Biosafety Study of Human Umbilical Cord Blood Mononuclear Cells Transduced with Adenoviral Vector Carrying Human Vascular Endothelial Growth Factor cDNA In Vitro
Authors: Ilnur I Salafutdinov , Dilara Z Gatina , Maria I Markelova , Ekaterina E Garanina , Sergey Yu Malanin , Ilnaz M Gazizov , Andrei A Izmailov , Albert A Rizvanov , Rustem R Islamov , András Palotás , Zufar Z Safiullov
Journal: Biomedicines .
PubMed ID: 37509661
Doi: 10.3390/biomedicines11072020
Products & Services: Catalog Antibody   
Role and neural regulation of clock genes in the rat pineal gland: Clock modulates amplitude of rhythmic expression of Aanat encoding the melatonin-producing enzyme
Authors: Aurea S Blancas-Velazquez, Tenna Bering, Signe Bille, Martin F Rath
Journal: J Pineal Res
PubMed ID: 37349875
Doi: 10.1111/jpi.12893
Breakthrough SARS-CoV-2 Omicron Variant in Individuals Primed with Heterologous Vaccines Enhances Inhibition Performance of Neutralizing Antibody to BA2 Parental Lineage
Authors: Jidapa Szekely, Piyawut Swangphon, Natthaphon Nanakorn, Panuttha Chaimuti, Teerapat Nualnoi, Paweena Wongwitwichot, Namchoke Somapa, Denpong Somapa, Theerakamol Pengsakul
Journal: Vaccines (Basel)
PubMed ID: 37515045
Doi: 10.3390/vaccines11071230
Products & Services: Molecular Biology Reagents   
Development of quantitative multiplex RT-qPCR one step assay for detection of hepatitis delta virus
Authors: Jackson Alves da Silva Queiroz, Tárcio Peixoto Roca, Rutilene Barbosa Souza, Luiz Fellype Alves de Souza, Ana Maísa Passos-Silva, André Luiz Ferreira da Silva, Eugênia de Castro E Silva, Lourdes Maria Pinheiro Borzacov, Rita de Cássia Pontello Rampazzo, Soraya Dos Santos Pereira, Thor Oliveira Dantas, Janaína Mazaro, Lívia Melo Villar, Juan Miguel Villalobos Salcedo, Daniel Archimedes da Matta, Deusilene Vieira
Journal: Sci Rep
PubMed ID: 37495613
Doi: 10.1038/s41598-023-37756-z
Products & Services: Molecular Biology Reagents   
Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity
Authors: Benedikt Goretzki, Christoph Wiedemann, Brett A McCray, Stefan L Schäfer, Jasmin Jansen, Frederike Tebbe, Sarah-Ana Mitrovic, Julia Nöth, Ainara Claveras Cabezudo, Jack K Donohue, Cy M Jeffries, Wieland Steinchen, Florian Stengel, Charlotte J Sumner, Gerhard Hummer, Ute A Hellmich
Journal: Nat Commun
PubMed ID: 37443299
Doi: 10.1038/s41467-023-39808-4
Products & Services: Plasmid DNA Preparation   
Structural basis of CXC chemokine receptor 1 ligand binding and activation
Authors: Naito Ishimoto, Jae-Hyun Park, Kouki Kawakami, Michiko Tajiri, Kenji Mizutani, Satoko Akashi, Jeremy R H Tame, Asuka Inoue, Sam-Yong Park
Journal: Nat Commun
PubMed ID: 37433790
Doi: 10.1038/s41467-023-39799-2
Products & Services: Gene Synthesis   
Spatially-Encoding Hydrogels With DNA to Control Cell Signaling
Authors: Namrata Ramani, C Adrian Figg, Alex J Anderson, Peter H Winegar, EunBi Oh, Sasha B Ebrahimi, Devleena Samanta, Chad A Mirkin
Journal: Adv Mater
PubMed ID: 37221642
Doi: 10.1002/adma.202301086
Products & Services: Recombinant Proteins   
A neural cell adhesion molecule from oyster Crassostrea gigas: Molecular identification and immune functional characterization
Authors: Xue Qiao, Conghui Liu, Weilin Wang, Chuanyan Yang, Meijia Li, Qilin Yi, Ning Kong, Limei Qiu, Xiyang Liu, Lingling Wang, Linsheng Song
Journal: Int J Biol Macromol
PubMed ID: 37429340
Doi: 10.1016/j.ijbiomac.2023.125756
Engineering the HK97 virus-like particle as a nanoplatform for biotechnology applications
Authors: Michael D Woods, Matthew Cali, Bubacarr Ceesay, Shandis Fancher, Gaini Ibrasheva, Suefian Kandeel, Manon Nassar, Ali Azghani, Brent Bill, Dustin P Patterson
Journal: J Mater Chem B
PubMed ID: 37345352
Doi: 10.1039/d3tb00318c
MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice
Authors: Nana Li, Junjie Yu, Meiyang Zhou, Fanyi Qiu, Xiao Wang, Zhengpin Wang
Journal: Biochem Biophys Res Commun
PubMed ID: 37451217
Doi: 10.1016/j.bbrc.2023.07.013
Structural and biochemical characterization of Schlafen11 N-terminal domain
Authors: Pengjiao Hou, Wei Hao, Bo Qin, Mengyun Li, Rong Zhao, Sheng Cui
Journal: Nucleic Acids Res
PubMed ID: 37293979
Doi: 10.1093/nar/gkad509
Products & Services: Gene Synthesis   
Tepsin binds LC3B to promote ATG9A export and delivery at the cell periphery
Authors: Natalie S Wallace, John E Gadbery, Cameron I Cohen, Amy K Kendall, Lauren P Jackson
Journal: biorxiv
PubMed ID: 37502979
Doi: 10.1101/2023.07.18.549521
An Immunoinformatics-Based Study of Mycobacterium tuberculosis Region of Difference-2 Uncharacterized Protein (Rv1987) as a Potential Subunit Vaccine Candidate for Preliminary Ex Vivo Analysis
Authors: Aregitu Mekuriaw Arega, Ajit Kumar Dhal, Kali Prasad Pattanaik, Sasmita Nayak, Rajani Kanta Mahapatra
Journal: Appl Biochem Biotechnol
PubMed ID: 37498378
Doi: 10.1007/s12010-023-04658-9
Products & Services: Gene Synthesis   
Targeting CXCR4-expressing Cancer Cells with Avidin-poly (lactic-co-glycolic acid) Nanoparticle Surface Modified with Biotinylated DV1 Peptide
Authors: Shiba Ansari, Madeeha Mudassir, B Vijayalekshmi, Parthaprasad Chattopadhyay
Journal: Int J Appl Basic Med Res
PubMed ID: 37614837
Doi: 10.4103/ijabmr.ijabmr_58_23
Products & Services: Peptide Synthesis   
Mesothelin-targeting T cell receptor fusion construct cell therapy in refractory solid tumors: phase 1/2 trial interim results
Authors: Raffit Hassan, Marcus Butler, Roisin E O'Cearbhaill, David Y Oh, Melissa Johnson, Kevin Zikaras, Munisha Smalley, Michael Ross, Janos L Tanyi, Azam Ghafoor, Nirali N Shah, Babak Saboury, Liang Cao, Alfonso Quintás-Cardama, David Hong
Journal: Nat Med
PubMed ID: 37501016
Doi: 10.1038/s41591-023-02452-y
Immunogenicity and safety of inactivated SARS-CoV-2 vaccine in haemodialysis patients: a prospective cohort study
Authors: Metalia Puspitasari, Prenali D Sattwika, Dzerlina S Rahari, Wynne Wijaya, Auliana R P Hidayat, Nyoman Kertia, Bambang Purwanto, Jarir At Thobari
Journal: Sci Rep
PubMed ID: 37463975
Doi: 10.1038/s41598-023-38628-2
Products & Services: Molecular Biology Reagents   
Monitoring SARS-CoV-2 variants in wastewater of Dhaka City, Bangladesh: approach to complement public health surveillance systems
Authors: Rehnuma Haque, Mohammad Enayet Hossain, Mojnu Miah, Mahbubur Rahman, Nuhu Amin, Ziaur Rahman, Md Shariful Islam, Mohammed Ziaur Rahman
Journal: Hum Genomics
PubMed ID: 37420264
Doi: 10.1186/s40246-023-00505-4
Products & Services: Molecular Biology Reagents   
Macrophage infectivity potentiator protein, a peptidyl prolyl cis-trans isomerase, essential for Coxiella burnetii growth and pathogenesis
Authors: Aleksandra W Debowski, Nicole M Bzdyl, David R Thomas, Nichollas E Scott, Christopher H Jenkins, Jua Iwasaki, Emily A Kibble, Chen Ai Khoo, Nicolas J Scheuplein, Pamela M Seibel, Theresa Lohr, Georgie Metters, Charles S Bond, Isobel H Norville, Keith A Stubbs, Nicholas J Harmer, Ulrike Holzgrabe, Hayley J Newton, Mitali Sarkar-Tyson
Journal: PLoS Pathog
PubMed ID: 37399210
Doi: 10.1371/journal.ppat.1011491
Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins
Authors: Ashley P Viera Ortiz, Gregory Cajka, Olamide A Olatunji, Bailey Mikytuck, Ophir Shalem, Edward B Lee
Journal: Brain
PubMed ID: 36516294
Doi: 10.1093/brain/awac479
Products & Services: DNA Sequencing   
Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1
Authors: Eva-Maria Thüring, Christian Hartmann, Janesha C Maddumage, Airah Javorsky, Birgitta E Michels, Volker Gerke, Lawrence Banks, Patrick O Humbert, Marc Kvansakul, Klaus Ebnet
Journal: Commun Biol
PubMed ID: 37430142
Doi: 10.1038/s42003-023-05088-3
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Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS–STING pathway
Authors: Jing An , Chuan-Ping Zhang , Hou-Yuan Qiu , Hong-Xia Zhang , Qiu-Bing Chen , Yu-Ming Zhang , Xin-Lin Lei , Cai-Xiang Zhang , Hao Yin , Ying Zhang
Journal: Nat Biomed Eng .
PubMed ID: 37500747
Doi: 10.1038/s41551-023-01073-7
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The combination of osimertinib with Raf inhibitor overcomes osimertinib resistance induced by KRAS amplification in EGFR-mutated lung cancer cells
Authors: Tae-Gul Lee, Hye-Min Kang, Seo Yun Kim, Hye-Ryoun Kim, Cheol Hyeon Kim
Journal: Exp Cell Res
PubMed ID: 37442265
Doi: 10.1016/j.yexcr.2023.113722
Combined Inhibition of the TGF-β1/Smad Pathway by and to Reduce Inflammation and Fibrosis in Primary Sclerosing Cholangitis
Authors: Yu Shen, Baorong Jiang, Chenchen Zhang, Qian Wu, Lei Li, Ping Jiang
Journal: Int J Mol Sci
PubMed ID: 37446187
Doi: 10.3390/ijms241311010
Interspersed expression of CUP-SHAPED COTYLEDON2 and REDUCED COMPLEXITY shapes Cardamine hirsuta complex leaf form
Authors: Neha Bhatia, David Wilson-Sánchez, Sören Strauss, Francesco Vuolo, Bjorn Pieper, Ziliang Hu, Léa Rambaud-Lavigne, Miltos Tsiantis
Journal: Curr Biol
PubMed ID: 37453425
Doi: 10.1016/j.cub.2023.06.037
Products & Services: Molecular Biology Reagents   
A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism
Authors: Yingjia Yao, Yunhan Zhang, Zexu Li, Zhisong Chen, Xiaofeng Wang, Zihan Li, Li Yu, Xiaolong Cheng, Wei Li, Wen-Jie Jiang, Hua-Jun Wu, Zezhong Feng, Jinfu Sun, Teng Fei
Journal: Biochem Biophys Res Commun
PubMed ID: 37467664
Doi: 10.1016/j.bbrc.2023.07.018
Products & Services: Molecular Biology Reagents   
Purification and characterization of human glycerol 3-phosphate dehydrogenases (mitochondrial and cytosolic) by NAD/NADH redox method
Authors: Superior Syngkli, Bidyadhar Das
Journal: Biochimie
PubMed ID: 37481063
Doi: 10.1016/j.biochi.2023.07.015
Products & Services: Molecular Biology Reagents   
Investigating the aggregation perspective of Dengue virus proteome
Authors: Shivani Krishna Kapuganti, Kumar Udit Saumya, Deepanshu Verma, Rajanish Giri
Journal: Virology
PubMed ID: 37473502
Doi: 10.1016/j.virol.2023.07.010
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Notch Intracellular Domains form Transcriptionally Active Heterodimeric Complexes on Sequence-paired Sites
Authors: Tana R Gazdik, Jacob J Crow, Tyler Lawton, Chloe J Munroe, Hannah Theriault, Travis M Wood, Allan R Albig
Journal: Res Sq
PubMed ID: 37546896
Doi: 10.21203/rs.3.rs-3147210/v1
Pathogenic CANVAS (AAGGG) repeats stall DNA replication due to the formation of alternative DNA structures
Authors: Julia A Hisey, Elina A Radchenko, Silvia Ceschi, Anastasia Rastokina, Nicholas H Mandel, Ryan J McGinty, Gabriel Matos-Rodrigues, Alfredo Hernandez, André Nussenzweig, Sergei M Mirkin
Journal: biorxiv
PubMed ID: 37546920
Doi: 10.1101/2023.07.25.550509
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Enhanced Carotenoid Production in Chlamydomonas reinhardtii via Overexpression of Endogenous and Exogenous Beta-Carotene Ketolase (BKT) Genes
Authors: Yuanhao Chen , Hong Du , Honghao Liang , Ting Hong , Tangcheng Li
Journal: Int J Mol Sci .
PubMed ID: 37511141
Doi: 1422-0067/24/14/11382
Products & Services: Gene Synthesis   
Prokaryotic Gabija complex senses and executes nucleotide depletion and DNA cleavage for antiviral defense
Authors: Rui Cheng , Fengtao Huang , Xueling Lu , Yan Yan , Bingbing Yu , Xionglue Wang , Bin Zhu
Journal: Cell Host Microbe .
PubMed ID: 37480847
Doi: 10.1016/j.chom.2023.06.014
Products & Services: Custom DNA/RNA Oligos   
Perdeuterated GbpA Enables Neutron Scattering Experiments of a Lytic Polysaccharide Monooxygenase
Authors: H V Sørensen, Mateu Montserrat-Canals, Jennifer S M Loose, S Zoë Fisher, Martine Moulin, Matthew P Blakeley, Gabriele Cordara, Kaare Bjerregaard-Andersen, Ute Krengel
Journal: ACS Omega
PubMed ID: 37599915
Doi: 10.1021/acsomega.3c02168
Viral manipulation of cell polarity signalling
Authors: Airah Javorsky, Patrick O Humbert, Marc Kvansakul
Journal: Biochim Biophys Acta Mol Cell Res
PubMed ID: 37437846
Doi: 10.1016/j.bbamcr.2023.119536
Products & Services: Molecular Biology Reagents   
N6-Methyladenosine Promotes Translation of VEGFA to Accelerate Angiogenesis in Lung Cancer
Authors: Haisheng Zhang, Jiawang Zhou, Jiexin Li, Zhaotong Wang, Zhuojia Chen, Ziyan Lv, Lichen Ge, Guoyou Xie, Guoming Deng, Yalan Rui, Hongbing Huang, Likun Chen, Hongsheng Wang
Journal: Cancer Res
PubMed ID: 37103476
Doi: 10.1158/0008-5472.CAN-22-2449
Products & Services: Custom RNAi Services   
Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma
Authors: Shiqun Wang , Wei Yan, Lingkai Kong , Shuguang Zuo , Jingyi Wu, Chunxiao Zhu , Huaping Huang , Bohao He, Jie Dong, Jiwu Wei
Journal: Nat Commun .
PubMed ID: 37474548
Doi: 10.1038/s41467-023-39683-z
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Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins
Authors: Haolan Wang , Ming Guo , Hudie Wei , Yongheng Chen
Journal: Comput Struct Biotechnol J .
PubMed ID: 37560128
Doi: 10.1016/j.csbj.2023.07.017
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The combined action of the intracellular regions regulates FGFR2 kinase activity
Authors: Chi-Chuan Lin , Lukasz Wieteska , Guillaume Poncet-Montange , Kin Man Suen , Stefan T Arold , Zamal Ahmed , John E Ladbury
Journal: Commun Biol .
PubMed ID: 37452126
Doi: 10.1038/s42003-023-05112-6
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Development of miniature base editors using engineered IscB nickase
Authors: Dingyi Han , Qingquan Xiao , Yifan Wang , Hainan Zhang , Xue Dong , Guoling Li , Xiangfeng Kong , Shihao Wang , Jinhui Song , Weihong Zhang , Jingxing Zhou , Lanting Bi , Yuan Yuan , Linyu Shi , Na Zhong , Hui Yang , Yingsi Zhou
Journal: Nat Methods .
PubMed ID: 37231266
Doi: 10.1038/s41592-023-01898-9
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Manganese-based microcrystals equipped with Ythdf1-targeted biomimeticnanovaccines for reinforced dendritic cell spatiotemporal orchestration
Authors: Feng Liu , Lulu Tan, Zheng Dai , Yang Wang , Lei Huang , Yang Zhang , Qian Cheng , Xin Li , Miao-Deng Liu, Lin Wang, Zheng Wang
Journal: Nano Today
Doi: 10.1016/j.nantod.2023.102112
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Biomimetic Nanofibrillar Hydrogel with Cell-Adaptable Network for Enhancing Cellular Mechanotransduction, Metabolic Energetics, and Bone Regeneration
Authors: Xian Xie , Zhuo Li , Xuefeng Yang , Boguang Yang , Zhixian Zong , Xuemei Wang , Liting Duan , Sien Lin , Gang Li , Liming Bian
Journal: J Am Chem Soc
PubMed ID: 37428960
Doi: 10.1021/jacs.3c02210
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Construction and characterization of a novel miniaturized filamentous phagemid for targeted mammalian gene transfer
Authors: Shirley Wong, Salma Jimenez, Roderick A Slavcev
Journal: Microb Cell Fact
PubMed ID: 37430278
Doi: 10.1186/s12934-023-02135-w
Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants
Authors: Ebene R Haycroft, Samantha K Davis, Pradhipa Ramanathan, Ester Lopez, Ruth A Purcell, Li Lynn Tan, Phillip Pymm, Bruce D Wines, P Mark Hogarth, Adam K Wheatley, Jennifer A Juno, Samuel J Redmond, Nicholas A Gherardin, Dale I Godfrey, Wai-Hong Tham, Kevin John Selva, Stephen J Kent, Amy W Chung
Journal: Med Microbiol Immunol
PubMed ID: 37477828
Doi: 10.1007/s00430-023-00773-w
Effectors of the Type VI Secretion System Have the Potential to Be Modified into Antimicrobial Peptides
Authors: Wenjia Lu, Hao Lu, Chenchen Wang, Gaoyan Wang, Wenqi Dong, Chen Tan
Journal: Microbiol Spectr
PubMed ID: 37470717
Doi: 10.1128/spectrum.00308-23
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Fusion of Substrate-Binding Domains Enhances the Catalytic Capacity of Keratinases and Promotes Enzymatic Conversion of Feather Waste
Authors: Xiaomei Ji, Zheng Peng, Jie Song, Guoqiang Zhang, Juan Zhang
Journal: J Agric Food Chem
PubMed ID: 37462367
Doi: 10.1021/acs.jafc.3c03064
Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G
Authors: Takahide Kouno, Satoshi Shibata, Megumi Shigematsu, Jaekyung Hyun, Tae Gyun Kim, Hiroshi Matsuo, Matthias Wolf
Journal: Nat Commun
PubMed ID: 37419875
Doi: 10.1038/s41467-023-39796-5
An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles
Authors: Huanhuan Li, Yixi Wu, Minke Li, Lu Guo, Yaqi Gao, Quan Wang, Jihua Zhang, Zhaohua Lai, Xing Zhang, Lixin Zhu, Ping Lan, Zihe Rao, Yingfang Liu, Huanhuan Liang
Journal: Nat Struct Mol Biol
PubMed ID: 37488357
Doi: 10.1038/s41594-023-01043-2
Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity
Authors: Jay C Groppe, Guorong Lu, Mary R Tandang-Silvas, Anupama Pathi, Shruti Konda, Jingfeng Wu, Viet Q Le, Andria L Culbert, Eileen M Shore, Kristi A Wharton, Frederick S Kaplan
Journal: Biomolecules
PubMed ID: 37509165
Doi: 10.3390/biom13071129
Tumor Site-Specific Cleavage Improves the Antitumor Efficacy of Antibody-Drug Conjugates
Authors: Keyuan Xu, Jiani Han, Liu Yang, Li Cao, Shuang Li, Zhangyong Hong
Journal: Int J Mol Sci
PubMed ID: 37446189
Doi: 10.3390/ijms241311011
Peptide/Nanoparticle Biointerfaces for Multistep Tandem Catalysis
Authors: Yuliana Perdomo, Joseph M Slocik, David M Phillips, Marc R Knecht
Journal: J Am Chem Soc
PubMed ID: 37478168
Doi: 10.1021/jacs.3c04097
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Preclinical characterization of the efficacy and safety of biologic N-001 as a novel pain analgesic for post-operative acute pain treatment
Authors: Derek Allen, Samerender Nagam Hanumantharao, Rylie McDonell, Karen-Amanda Irvine, Peyman Sahbaie, David Clark, Paul Blum
Journal: Sci Rep
PubMed ID: 37479740
Doi: 10.1038/s41598-023-38618-4
Low cross reactivity between wild type and deamidated AAV can lead to false negative results in immune monitoring T-cell assays
Authors: So Jin Bing, Stephanee Warrington, Ronit Mazor
Journal: Front Immunol
PubMed ID: 37469509
Doi: 10.3389/fimmu.2023.1211529
RNA m5C methylation orchestrates BLCA progression via macrophage reprogramming
Authors: Dali Yan, Yongsong Xie, Liyuan Huang, Yi Zhang, Runhuan Gu, Huaibing Xie, Xing Huang, Hao Luo
Journal: J Cell Mol Med
PubMed ID: 37408139
Doi: 10.1111/jcmm.17826
Hypoxic papillary thyroid carcinoma cells-secreted exosomes deliver miR-221-3p to normoxic tumor cells to elicit a pro-tumoral effect by regulating the ZFAND5
Authors: Fan Yu, Xianzhao Deng, Yong Zhong, Bomin Guo, Xiaoping Zhang, Bo Wu
Journal: Exp Cell Res
PubMed ID: 37488006
Doi: 10.1016/j.yexcr.2023.113716
Structural Basis for the Ribonuclease Activity of a Thermostable CRISPR-Cas13a from Thermoclostridium caenicola
Authors: Feng Wang, Chendi Zhang, Haijiang Xu, Wanting Zeng, Lixin Ma, Zhuang Li
Journal: J Mol Biol
PubMed ID: 37442412
Doi: 10.1016/j.jmb.2023.168197
Activation of PDGF Signaling in the Adult Muscle Stem Cell Niche in Patients With Type 2 Diabetes Mellitus
Authors: Alexandra Fahrner, Nikoleta Alchus Laiferová, Barbara Ukropcová, Jozef Ukropec, Jan Krützfeldt
Journal: J Clin Endocrinol Metab
PubMed ID: 36702759
Doi: 10.1210/clinem/dgad041
Integrated immunoinformatics and subtractive proteomics approach for multi-epitope vaccine designing to combat TIGR4
Authors: Sami S Ashgar, Hani Faidah, Farkad Bantun, Naif A Jalal, Naeem F Qusty, Abdulla Darwish, Shafiul Haque, Essam M Janahi
Journal: Front Mol Biosci
PubMed ID: 37560463
Doi: 10.3389/fmolb.2023.1212119
Long Non-coding RNA LINC00342 Promotes the Proliferation, Invasion, and Migration of Primary Hepatocellular Carcinoma Cells by Regulating the Expression of miRNA-19a-3p, miRNA-545-5p, and miRNA-203a-3p
Authors: Zong-Xi Yao, Jun-Hao Tu, Yu-Lin Liu, Xiao-Feng Xue, Lei Qin
Journal: Biochem Genet
PubMed ID: 37395850
Doi: 10.1007/s10528-023-10420-x
A bistable autoregulatory module in the developing embryo commits cells to binary expression fates
Authors: Jiaxi Zhao, Mindy Liu Perkins, Matthew Norstad, Hernan G Garcia
Journal: Curr Biol
PubMed ID: 37453424
Doi: 10.1016/j.cub.2023.06.060
Generation of Bioactive Peptides from sp and Assessment of Their Potential for Use in the Prevention of Hypertension, Inflammation and Pain
Authors: Maria Hayes, Rotimi E Aluko, Elena Aurino, Leticia Mora
Journal: Mar Drugs
PubMed ID: 37623703
Doi: 10.3390/md21080422
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TLR5S negatively regulates the TLR5M-mediated NF-κB signaling pathway in Epinephelus coioides
Authors: Liangge He, Xue Yu, Yulin Zhao, Haoran Lin, Yong Zhang, Danqi Lu
Journal: Int J Biol Macromol
PubMed ID: 37517756
Doi: 10.1016/j.ijbiomac.2023.126048
Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays
Authors: Rui Qing, Mantian Xue, Jiayuan Zhao, Lidong Wu, Andreas Breitwieser, Eva Smorodina, Thomas Schubert, Giovanni Azzellino, David Jin, Jing Kong, Tomás Palacios, Uwe B Sleytr, Shuguang Zhang
Journal: Sci Adv
PubMed ID: 37478177
Doi: 10.1126/sciadv.adf1402
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An integrated genomic approach identifies follistatin as a target of the p63-epidermal growth factor receptor oncogenic network in head and neck squamous cell carcinoma
Authors: Akinsola Oyelakin, Jennifer Sosa, Kasturi Bala Nayak, Alexandra Glathar, Christian Gluck, Isha Sethi, Maria Tsompana, Norma Nowak, Michael Buck, Rose-Anne Romano, Satrajit Sinha
Journal: NAR Cancer
PubMed ID: 37492374
Doi: 10.1093/narcan/zcad038
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Author Correction: A pan-influenza antibody inhibiting neuraminidase via receptor mimicry
Authors: Corey Momont, Ha V Dang, Fabrizia Zatta, Kevin Hauser, Caihong Wang, Julia di Iulio, Andrea Minola, Nadine Czudnochowski, Anna De Marco, Kaitlin Branch, David Donermeyer, Siddhant Vyas, Alex Chen, Elena Ferri, Barbara Guarino, Abigail E Powell, Roberto Spreafico, Samantha S Yim, Dale R Balce, Istvan Bartha, Marcel Meury, Tristan I Croll, David M Belnap, Michael A Schmid, William Timothy Schaiff, Jessica L Miller, Elisabetta Cameroni, Amalio Telenti, Herbert W Virgin, Laura E Rosen, Lisa A Purcell, Antonio Lanzavecchia, Gyorgy Snell, Davide Corti, Matteo Samuele Pizzuto
Journal: Nature
PubMed ID: 37407829
Doi: 10.1038/s41586-023-06385-x
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Systemic delivery of specific and efficient CRISPR/Cas9 system targeting HPV16 oncogenes using LL-37 antimicrobial peptide in C57BL/6 mice
Authors: Niloofar Khairkhah, Azam Bolhassani, Farzad Rajaei, Reza Najafipour
Journal: J Med Virol
PubMed ID: 37403986
Doi: 10.1002/jmv.28934
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A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury
Authors: Chen Yang, Huidie Xu, Dong Yang, Yunhao Xie, Mingrui Xiong, Yu Fan, XiKai Liu, Yu Zhang, Yushuo Xiao, Yuchen Chen, Yihao Zhou, Liangliang Song, Chen Wang, Anlin Peng, Robert B Petersen, Hong Chen, Kun Huang, Ling Zheng
Journal: Nat Commun
PubMed ID: 37460623
Doi: 10.1038/s41467-023-40036-z
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Ice Recrystallization Inhibition Activity of Soy Protein Hydrolysates
Authors: Madison Fomich, Vermont P Día, Uvinduni I Premadasa, Benjamin Doughty, Hari B Krishnan, Tong Wang
Journal: J Agric Food Chem
PubMed ID: 37466256
Doi: 10.1021/acs.jafc.2c08701
Transcriptomic analysis of hepatocytes reveals the association between ubiquitin-specific peptidase 1 and yes-associated protein 1 during liver regeneration
Authors: Yalei Zhao, Fen Zhang, Xiaoli Zhang, Zuhong Li, Qian Li, Tianzhi Ni, Ruojing Wang, Liangru Liu, Yingli He, Yingren Zhao
Journal: Regen Ther
PubMed ID: 37534236
Doi: 10.1016/j.reth.2023.07.004
Products & Services: Molecular Biology Reagents   
The ubiquitin-protein ligase MIEL1 localizes to peroxisomes to promote seedling oleosin degradation and lipid droplet mobilization
Authors: Melissa S Traver , Bonnie Bartel
Journal: Proc Natl Acad Sci U S A .
PubMed ID: 37410814
Doi: 10.1073/pnas.2304870120
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Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity
Authors: Hudie Wei , Haolan Wang , Genxin Wang , Lingzhi Qu , Longying Jiang , Shuyan Dai , Xiaojuan Chen , Ye Zhang , Zhuchu Chen , Youjun Li , Ming Guo , Yongheng Chen
Journal: Nat Commun .
PubMed ID: 37463921
Doi: 10.1038/s41467-023-40087-2
Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer
Authors: Apostolia M Tsimberidou, Kerstin Guenther, Borje S Andersson, Regina Mendrzyk, Amir Alpert, Claudia Wagner, Anna Nowak, Katrin Aslan, Arun Satelli, Fabian Richter, Sabrina Kuttruff-Coqui, Oliver Schoor, Jens Fritsche, Zoe Coughlin, Ali S Mohamed, Kerry Sieger, Becky Norris, Rita Ort, Jennifer Beck, Henry Hiep Vo, Franziska Hoffgaard, Manuel Ruh, Linus Backert, Ignacio I Wistuba, David Fuhrmann, Nuhad K Ibrahim, Van Karlyle Morris, Bryan K Kee, Daniel M Halperin, Graciela M Nogueras-Gonzalez, Partow Kebriaei, Elizabeth J Shpall, David Vining, Patrick Hwu, Harpreet Singh, Carsten Reinhardt, Cedrik M Britten, Norbert Hilf, Toni Weinschenk, Dominik Maurer, Steffen Walter
Journal: Cancer Immunol Res
PubMed ID: 37172100
Doi: 10.1158/2326-6066.CIR-22-0444
Protein oxidation increases SAMHD1 binding ssDNA via its regulatory site
Authors: Theresa L Simermeyer, Stephanie Batalis, LeAnn C Rogers, Owen J Zalesak, Thomas Hollis
Journal: Nucleic Acids Res
PubMed ID: 37246644
Doi: 10.1093/nar/gkad447
Functionally diverse front-end desaturases are widespread in the phylum Annelida
Authors: Marc Ramos-Llorens, Francisco Hontoria, Juan C Navarro, David E K Ferrier, Óscar Monroig
Journal: Biochim Biophys Acta Mol Cell Biol Lipids
PubMed ID: 37517549
Doi: 10.1016/j.bbalip.2023.159377
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Caspase-mediated LPS sensing and pyroptosis signaling in
Authors: Shouwen Chen, Shuxin Li, Hao Chen, Yuxin Gong, Dahai Yang, Yuanxing Zhang, Qin Liu
Journal: Sci Adv
PubMed ID: 37478191
Doi: 10.1126/sciadv.adh4054

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