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High-volume hybridoma sequencing on the NeuroMabSeq platform enables efficient generation of recombinant monoclonal antibodies and scFvs for neuroscience research

Authors: Keith G Mitchell, Belvin Gong, Samuel S Hunter, Diana Burkart-Waco, Clara E Gavira-O'Neill, Kayla M Templeton, Madeline E Goethel, Malgorzata Bzymek, Leah M MacNiven, Karl D Murray, Matthew L Settles, Lutz Froenicke, James S Trimmer

Journal: Sci Rep

PubMed ID: 37758930

Doi: 10.1038/s41598-023-43233-4

Products & Services: Proteins, Expression, Isolation and Analysis

Epidermal growth factor receptor regulates lineage plasticity driving transformation to small cell lung cancer

Authors: Meng Jing, Xia He, Cheng Zhi Cai, Qi Zhi Ma, Kai Li, Ben Xia Zhang, Yuan Yin, Ming Song Shi, Yong Sheng Wang

Journal: Biochem Biophys Res Commun

PubMed ID: 37783120

Doi: 10.1016/j.bbrc.2023.09.047

Products & Services: Proteins, Expression, Isolation and Analysis

Antigen-specific CD4 T cells exhibit distinct transcriptional phenotypes in the lymph node and blood following vaccination in humans

Authors: Philip Mudd, Nicholas Borcherding, Wooseob Kim, Michael Quinn, Fangjie Han, Julian Zhou, Alexandria Sturtz, Aaron Schmitz, Tingting Lei, Stefan Schattgen, Michael Klebert, Teresa Suessen, William Middleton, Charles Goss, Chang Liu, Jeremy Crawford, Paul Thomas, Sharlene Teefey, Rachel Presti, Jane O'Halloran, Jackson Turner, Ali Ellebedy

Journal: Res Sq

PubMed ID: 37790414

Doi: 10.21203/rs.3.rs-3304466/v1

Products & Services: Proteins, Expression, Isolation and Analysis

designed Hsp70 activator dissolves intracellular condensates

Authors: Jason Z Zhang, Nathan Greenwood, Jason Hernandez, Josh T Cuperus, Buwei Huang, Bryan D Ryder, Christine Queitsch, Jason E Gestwicki, David Baker

Journal: biorxiv

PubMed ID: 37781598

Doi: 10.1101/2023.09.18.558356

Products & Services: Proteins, Expression, Isolation and Analysis

Role of myristoylation in modulating PCaP1 interaction with calmodulin

Authors: Marco Pedretti, Filippo Favretto, Francesca Troilo, Moira Giovannoni, Carolina Conter, Benedetta Mattei, Paola Dominici, Carlo Travaglini-Allocatelli, Adele Di Matteo, Alessandra Astegno

Journal: Plant Physiol Biochem

PubMed ID: 37717348

Doi: 10.1016/j.plaphy.2023.108003

Products & Services: Proteins, Expression, Isolation and Analysis

Adaptive Adhesions of Barnacle-Inspired Adhesive Peptides

Authors: Evan Angelo Quimada Mondarte, Jining Wang, Jing Yu

Journal: ACS Biomater Sci Eng

PubMed ID: 37722068

Doi: 10.1021/acsbiomaterials.3c01047

Products & Services: Peptide Synthesis

Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation

Authors: Pan-Yu Chen, Benjamin J Huang, Max Harris, Christopher Boone, Weijie Wang, Heidi Carias, Brian Mesiona, Daniela Mavrici, Amanda C Kohler, Gideon Bollag, Chao Zhang, Ying Zhang, Kevin Shannon

Journal: JCI Insight

PubMed ID: 37681415

Doi: 10.1172/jci.insight.168445

Products & Services: Molecular Biology Reagents

Multi-epitope Antigen for Specific Serological Detection of Dengue Viruses

Authors: Samuel Santos Pereira, Robert Andreata-Santos, Maria Fernanda de Castro-Amarante, Aléxia Adrianne Venceslau-Carvalho, Natiely Silva Sales, Mariângela de Oliveira Silva, Rúbens Prince Dos Santos Alves, Patrícia Jungmann, Luís Carlos de Souza Ferreira

Journal: Viruses

PubMed ID: 37766342

Doi: 10.3390/v15091936

Products & Services: Molecular Biology Reagents

The plant pathogenic bacterium Liberibacter solanacearum induces calcium-regulated autophagy in midgut cells of its insect vector

Authors: Poulami Sarkar, Ola Jassar, Murad Ghanim

Journal: Microbiol Spectr

PubMed ID: 37768086

Doi: 10.1128/spectrum.01301-23

Products & Services: Monoclonal Antibody Services

Correction: Kaewchim et al Neutralizing and Enhancing Epitopes of the SARS-CoV-2 Receptor-Binding Domain (RBD) Identified by Nanobodies 2023, Viruses, 125215

Authors: Kanasap Kaewchim, Kittirat Glab-Ampai, Kodchakorn Mahasongkram, Thanatsaran Saenlom, Watayagorn Thepsawat, Monrat Chulanetra, Kiattawee Choowongkomon, Nitat Sookrung, Wanpen Chaicumpa

Journal: Viruses

PubMed ID: 37896913

Doi: 10.3390/v15101979

Products & Services: Peptide Synthesis

Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice

Authors: Liansheng Zhang, Zhiheng Jia, Qiang Wu, Tao Bai, Bo Wang, Xinde Hu, Tianwen Li, Xingyu Liu, Jiqiang Fu, Yuelei Chen, Xiaoyan Ding, Zhen Liu, Zhengzheng Xu, Haibo Zhou

Journal: Nat Metab

PubMed ID: 37679556

Doi: 10.1038/s42255-023-00887-8

Products & Services: Proteins, Expression, Isolation and Analysis

Widespread monoclonal IgE antibody convergence to an immunodominant, proanaphylactic Ara h 2 epitope in peanut allergy

Authors: Derek Croote , Joyce J W Wong , Cyprien Pecalvel , Edouard Leveque , Natacha Casanovas , Jasper B J Kamphuis , Paige Creeks , Johanna Romero , Saba Sohail , Daniel Bedinger , Kari C Nadeau , Rebecca S Chinthrajah , Laurent L Reber , Henry B Lowman

Journal: J Allergy Clin Immunol.

PubMed ID: 37748654

Doi: 10.1016/j.jaci.2023.08.035

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Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge

Authors: Qianyun Liu, Haiyan Zhao , Zhiqiang Li , Zhen Zhang , Rui Huang , Mengxue Gu , Ke Zhuang , Qing Xiong , Xianying Chen , Weiyi Yu, Shengnan Qian , Yuzhen Zhang , Xue Tan , Muyi Zhang , Feiyang Yu , Ming Guo , Zhixiang Huang, Xin Wang , Wenjie Xiang , Bihao Wu , Fanghua Mei , Kun Cai , Limin Zhou , Li Zhou , Ying Wu , Huan Yan , Sheng Cao, Ke Lan, Yu Chen

Journal: Signal Transduct Target Ther .

PubMed ID: 37704615

Doi: 10.1038/s41392-023-01615-0

Products & Services: Proteins, Expression, Isolation and Analysis

Expression of V-nitrogenase and Fe-nitrogenase in is controlled by molybdenum, fixed nitrogen, and the expression of Mo-nitrogenase

Authors: Melissa Chanderban, Christopher A Hill, Ahmed E Dhamad, Daniel J Lessner

Journal: Appl Environ Microbiol

PubMed ID: 37695043

Doi: 10.1128/aem.01033-23

Products & Services: Proteins, Expression, Isolation and Analysis

Combined prediction and design reveals the target recognition mechanism of an intrinsically disordered protein interaction domain

Authors: Xiuhong Hu, Yang Xu, Chenchen Wang, Yufeng Liu, Lu Zhang, Jiahai Zhang, Wenning Wang, Quan Chen, Haiyan Liu

Journal: Proc Natl Acad Sci U S A

PubMed ID: 37722056

Doi: 10.1073/pnas.2305603120

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A magneto-activated nanoscale cytometry platform for molecular profiling of small extracellular vesicles

Authors: Kangfu Chen, Bill T V Duong, Sharif U Ahmed, Piriththiv Dhavarasa, Zongjie Wang, Mahmoud Labib, Connor Flynn, Jingya Xu, Yi Y Zhang, Hansen Wang, Xiaolong Yang, Jagotamoy Das, Hossein Zargartalebi, Yuan Ma, Shana O Kelley

Journal: Nat Commun

PubMed ID: 37696888

Doi: 10.1038/s41467-023-41285-8

Products & Services: Proteins, Expression, Isolation and Analysis

Structural and functional insights into δ-poly-L-ornithine polymer biosynthesis from Acinetobacter baumannii

Authors: Ketan D Patel, Andrew M Gulick

Journal: Commun Biol

PubMed ID: 37752201

Doi: 10.1038/s42003-023-05362-4

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Temporal logic circuits implementation using a dual cross-inhibition mechanism based on DNA strand displacement

Authors: Yuan Liu, Xiaokang Zhang, Xun Zhang, Xin Liu, Bin Wang, Qiang Zhang, Xiaopeng Wei

Journal: RSC Adv

PubMed ID: 37701285

Doi: 10.1039/d3ra03995a

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The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis

Authors: Svenja Lenhard, Sarah Gerlich, Azkia Khan, Saskia Rödl, Jan-Eric Bökenkamp, Esra Peker, Christine Zarges, Janina Faust, Zuzana Storchova, Markus Räschle, Jan Riemer, Johannes M Herrmann

Journal: J Cell Biol

PubMed ID: 37682539

Doi: 10.1083/jcb.202303002

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Robust Strategy for Hit-to-Lead Discovery: NMR for SAR

Authors: Sacha T Larda, Yann Ayotte, Maria M Denk, Paul Coote, Gregory Heffron, David Bendahan, Fatma Shahout, Nicolas Girard, Mustapha Iddir, Patricia Bouchard, Francois Bilodeau, Simon Woo, Luc J Farmer, Steven R LaPlante

Journal: J Med Chem

PubMed ID: 37732695

Doi: 10.1021/acs.jmedchem.3c00656

Products & Services: Plasmid DNA Preparation

Characterization of p53/p63/p73 and Myc expressions during embryogenesis of the sea urchin

Authors: Blaine Grant, Paola Alejandra Sundaram Buitrago, Beatriz C Mercado, Mamiko Yajima

Journal: Dev Dyn

PubMed ID: 37698352

Doi: 10.1002/dvdy.656

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Metabolic engineering of commensal bacteria for gut butyrate delivery and dissection of host-microbe interaction

Authors: Xu Gong , Hongwei Geng , Yun Yang , Shuyi Zhang , Zilong He , Yubo Fan , Fengyi Yin , Zhifa Zhang , Guo-Qiang Chen

Journal: Metab Eng .

PubMed ID: 37717646

Doi: 10.1016/j.ymben.2023.09.008

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T-Lymphocytes Activated by Dendritic Cells Loaded by Tumor-Derived Vesicles Decrease Viability of Melanoma Cells In Vitro

Authors: Ivan Yurevich Filin , Yuriy Pavlovich Mayasin , Chulpan Bulatovna Kharisova, Anna Valerevna Gorodilova , Daria Sergeevna Chulpanova , Kristina Viktorovna Kitaeva, Albert Anatolyevich Rizvanov and Valeria Vladimirovna Solovyeva

Journal: Curr. Issues Mol. Biol.

Doi: 10.3390/cimb45100493

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Evolutionary fingerprints of EMT in pancreatic cancers

Authors: Luigi Perelli, Li Zhang, Sarah Mangiameli, Andrew J C Russell, Francesca Giannese, Fuduan Peng, Federica Carbone, Courtney Le, Hania Khan, Francesca Citron, Melinda Soeung, Truong Nguyen Anh Lam, Sebastian Lundgren, Cihui Zhu, Desiree Catania, Ningping Feng, Enrico Gurreri, Alessandro Sgambato, Giampaolo Tortora, Giulio F Draetta, Giovanni Tonon, Andrew Futreal, Virginia Giuliani, Alessandro Carugo, Andrea Viale, Timothy P Heffernan, Linghua Wang, Davide Cittaro, Fei Chen, Giannicola Genovese

Journal: biorxiv

PubMed ID: 37786705

Doi: 10.1101/2023.09.18.558231

Products & Services: Proteins, Expression, Isolation and Analysis

Preclinical Development and Characterization of Novel Adeno-Associated Viral Vectors for the Treatment of Lipoprotein Lipase Deficiency

Authors: Neel Mehta, Rénald Gilbert, Parminder S Chahal, Maria J Moreno, Nasha Nassoury, Nathalie Coulombe, Viktoria Lytvyn, Mario Mercier, Dorothy Fatehi, Wendy Lin, Emily M Harvey, Lin-Hua Zhang, Nazila Nazemi-Moghaddam, Seyyed Mehdy Elahi, Colin J D Ross, Danica B Stanimirovic, Michael R Hayden

Journal: Hum Gene Ther

PubMed ID: 37597209

Doi: 10.1089/hum.2023.075

Products & Services: Proteins, Expression, Isolation and Analysis

A monoclonal antibody-based sandwich ELISA for measuring canine Thymidine kinase 1 protein and its role as biomarker in canine lymphoma

Authors: Hanan Sharif, Sara Saellström, Bhavya Kolli, Kiran Kumar Jagarlamudi, Liya Wang, Henrik Rönnberg, Staffan Eriksson

Journal: Front Vet Sci

PubMed ID: 37808109

Doi: 10.3389/fvets.2023.1243853

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Recombinant Lactococcus lactis Expressing Human LL-37 Prevents Deaths from Viral Infections in Piglets and Chicken

Authors: Hanlin Zhang, Meng Dong, Huihui Xu, Hongyue Li, Aihua Zheng, Gang Sun, Wanzhu Jin

Journal: Probiotics Antimicrob Proteins

PubMed ID: 37743432

Doi: 10.1007/s12602-023-10155-6

Products & Services: Molecular Biology Reagents

The role of signaling compounds in enhancing rice allelochemicals for sustainable agriculture: an overview

Authors: Babita Patni, Malini Bhattacharyya, Anshika Pokhriyal

Journal: Planta

PubMed ID: 37775539

Doi: 10.1007/s00425-023-04241-w

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A combination of two resistance mechanisms is critical for tick-borne encephalitis virus escape from a broadly neutralizing human antibody

Authors: Pavel Svoboda, Jan Haviernik, Petr Bednar, Milos Matkovic, Tomás Cervantes Rincón, Jennifer Keeffe, Martin Palus, Jiri Salat, Marianna Agudelo, Michel C Nussenzweig, Andrea Cavalli, Davide F Robbiani, Daniel Ruzek

Journal: Cell Rep

PubMed ID: 37715951

Doi: 10.1016/j.celrep.2023.113149

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BcNAC056 Interacts with BcWRKY1 to Regulate Leaf Senescence in Pak Choi

Authors: Shuilin Yuan, Yuan Wang, Die Hu, Weitong Zhu, Dong Xiao, Tongkun Liu, Xilin Hou, Ying Li

Journal: Plant Cell Physiol

PubMed ID: 37566556

Doi: 10.1093/pcp/pcad073

Products & Services: Molecular Biology Reagents

The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease

Authors: Norman Tran, Sathish Dasari, Sarah A E Barwell, Matthew J McLeod, Subha Kalyaanamoorthy, Todd Holyoak, Aravindhan Ganesan

Journal: Nat Commun

PubMed ID: 37699927

Doi: 10.1038/s41467-023-40023-4

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Interference of a mammalian circRNA regulates lipid metabolism reprogramming by targeting miR‑24‑3p/Igf2/PI3K‑AKT‑mTOR and Igf2bp2/Ucp1 axis

Authors: Jiahao Shao , Meigui Wang , Anjing Zhang , Zheliang Liu , Genglong Jiang , Tao Tang , Jie Wang , Xianbo Jia , Songjia Lai

Journal: Cell Mol Life Sci .

PubMed ID: 37587272

Doi: 10.1007/s00018-023-04899-1

Products & Services: Proteins, Expression, Isolation and Analysis

A systematic safety pipeline for selection of T-cell receptors to enter clinical use

Authors: Zsofia Foldvari , Cathrine Knetter , Weiwen Yang , Thea Johanne Gjerdingen , Ravi Chand Bollineni , Trung The Tran , Fridtjof Lund-Johansen , Arne Kolstad , Kimberley Drousch , Robert Klopfleisch , Matthias Leisegang , Johanna Olweus

Journal: NPJ Vaccines .

PubMed ID: 37607971

Doi: 10.1038/s41541-023-00713-y

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Strand-preferred base editing of organellar and nuclear genomes using CyDENT

Authors: Jiacheng Hu , Yu Sun , Boshu Li , Zhen Liu , Zhiwei Wang , Qiang Gao , Mengyue Guo , Guanwen Liu , Kevin Tianmeng Zhao , Caixia Gao

Journal: Nat Biotechnol .

PubMed ID: 37640945

Doi: 10.1038/s41587-023-01910-9

Products & Services: Gene Synthesis

Comparative Longitudinal Serological Study of Anti-SARS-CoV-2 Antibody Profiles in People with COVID-19

Authors: Marilou H Barrios, Suellen Nicholson, Rowena A Bull, Marianne Martinello, William Rawlinson, Michael Mina, Jeffrey J Post, Bernard Hudson, Nicole Gilroy, Andrew R Lloyd, Pamela Konecny, Francesca Mordant, Mike Catton, Kanta Subbarao, Leon Caly, Julian Druce, Hans J Netter

Journal: Microorganisms

PubMed ID: 37630545

Doi: 10.3390/microorganisms11081985

Products & Services: Molecular Biology Reagents

Iguratimod attenuated fibrosis in systemic sclerosis via targeting early growth response 1 expression

Authors: Lichong Shen, Hanlin Yin, Li Sun, Zhiliang Zhang, Yuyang Jin, Shan Cao, Qiong Fu, Chaofan Fan, Chunde Bao, Liangjing Lu, Yifan Zhan, Xiaojiang Xu, Xiaoxiang Chen, Qingran Yan

Journal: Arthritis Res Ther

PubMed ID: 37596660

Doi: 10.1186/s13075-023-03135-2

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Extended-Gate Field-Effect Transistor Consisted of a CD9 Aptamer and MXene for Exosome Detection in Human Serum

Authors: Jeongyun An, Hyunjun Park, Jinmyeong Kim, Hanbin Park, Tae-Hyung Kim, Chulhwan Park, Jeonghyun Kim, Min-Ho Lee, Taek Lee

Journal: ACS Sens

PubMed ID: 37585601

Doi: 10.1021/acssensors.3c00879

Products & Services: Proteins, Expression, Isolation and Analysis

Sarkosyl differentially solubilizes patient-derived alpha-synuclein fibril strains

Authors: Hjalte Gram, Vasileios Theologidis, Thomas Boesen, Poul Henning Jensen

Journal: Front Mol Biosci

PubMed ID: 37621995

Doi: 10.3389/fmolb.2023.1177556

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Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif

Authors: Peter Schofield, Alexander I Taylor, Jérôme Rihon, Cristian D Peña Martinez, Sacha Zinn, Charles-Alexandre Mattelaer, Jennifer Jackson, Gurpreet Dhaliwal, Guy Schepers, Piet Herdewijn, Eveline Lescrinier, Daniel Christ, Philipp Holliger

Journal: Nucleic Acids Res

PubMed ID: 37439359

Doi: 10.1093/nar/gkad592

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Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells

Authors: Kevin M Rattigan, Zuzana Brabcova, Daniele Sarnello, Martha M Zarou, Kiron Roy, Ryan Kwan, Lucie de Beauchamp, Amy Dawson, Angela Ianniciello, Ahmed Khalaf, Eric R Kalkman, Mary T Scott, Karen Dunn, David Sumpton, Alison M Michie, Mhairi Copland, Saverio Tardito, Eyal Gottlieb, G Vignir Helgason

Journal: Nat Commun

PubMed ID: 37591854

Doi: 10.1038/s41467-023-40222-z

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Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

Authors: Gabriella O Estevam, Edmond M Linossi, Christian B Macdonald, Carla A Espinoza, Jennifer M Michaud, Willow Coyote-Maestas, Eric A Collisson, Natalia Jura, James S Fraser

Journal: biorxiv

PubMed ID: 37577651

Doi: 10.1101/2023.08.03.551866

Products & Services: Proteins, Expression, Isolation and Analysis

Immune memory shapes human polyclonal antibody responses to H2N2 vaccination

Authors: Yuhe R Yang, Julianna Han, Hailee R Perrett, Sara T Richey, Abigail M Jackson, Alesandra J Rodriguez, Rebecca A Gillespie, Sarah O'Connell, Julie E Raab, Lauren Y Cominsky, Ankita Chopde, Masaru Kanekiyo, Katherine V Houser, Grace L Chen, Adrian B McDermott, Sarah F Andrews, Andrew B Ward

Journal: biorxiv

PubMed ID: 37781590

Doi: 10.1101/2023.08.23.554525

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Characterization of the novel glucose-methanol-choline (GMC) oxidoreductase EnOXIO1 in Eimeria necatrix

Authors: Feiyan Wang, Zhuang Ye, Yue Liu, Lele Wang, Shijie Su, Zhaofeng Hou, Jinjun Xu, Jianping Tao, Dandan Liu

Journal: Vet Parasitol

PubMed ID: 37567028

Doi: 10.1016/j.vetpar.2023.110002

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Sensitive, non-immunogenic imaging of cancer metastases and immunotherapy response

Authors: Joseph R Merrill, Alessandra Inguscio, Taemoon Chung, Breanna Demestichas, Libia A Garcia, Jill Habel, David Y Lewis, Tobias Janowitz, Scott K Lyons

Journal: Cell Stress

PubMed ID: 37664695

Doi: 10.15698/cst2023.08.288

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Transplantation elicits a clonally diverse CD8 T cell response that is comprised of potent CD43 effectors

Authors: Gregory S Cohen, Melissa A Kallarakal, Sahana Jayaraman, Francis I Ibukun, Katherine P Tong, Linda D Orzolek, H Benjamin Larman, Scott M Krummey

Journal: Cell Rep

PubMed ID: 37590141

Doi: 10.1016/j.celrep.2023.112993

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Structural and functional characterisation of Tst2, a novel TRPV1 inhibitory peptide from the Australian sea anemone Telmatactis stephensoni

Authors: Khaled A Elnahriry, Dorothy C C Wai, Lauren M Ashwood, Muhammad Umair Naseem, Tibor G Szanto, Shaodong Guo, Gyorgy Panyi, Peter J Prentis, Raymond S Norton

Journal: Biochim Biophys Acta Proteins Proteom

PubMed ID: 37640250

Doi: 10.1016/j.bbapap.2023.140952

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Small secreted peptides (SSPs) in tomato and their potential roles in drought stress response

Authors: Kexin Xu, Dongdong Tian, Tingjin Wang, Aijun Zhang, Mohamed Abdou Youssef Elsadek, Weihong Liu, Liping Chen, Yongfeng Guo

Journal: Mol Hortic

PubMed ID: 37789434

Doi: 10.1186/s43897-023-00063-2

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Targeted large fragment deletion in plants using paired crRNAs with type I CRISPR system

Authors: Yingnan Li, Boyu Huang, Jian Chen, Liangliang Huang, Jianghai Xu, Yingying Wang, Guanghui Cui, Haiming Zhao, Beibei Xin, Weibin Song, Jian-Kang Zhu, Jinsheng Lai

Journal: Plant Biotechnol J

PubMed ID: 37641539

Doi: 10.1111/pbi.14122

Products & Services: Proteins, Expression, Isolation and Analysis

The long-term effects of intermittent theta burst stimulation on Alzheimer's disease-type pathologies in APP/PS1 mice

Authors: Hao Huang, Yang Zhu, Lingyi Liao, Shihao Gao, Yong Tao, Xiangqin Fang, Yan Lian, Changyue Gao

Journal: Brain Res Bull

PubMed ID: 37586425

Doi: 10.1016/j.brainresbull.2023.110735

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Spatially differential regulation of ATF2 phosphorylation contributes to warning coloration of gregarious locusts

Authors: Xinle Kang, Meiling Yang, Xiaoshuang Cui, Huimin Wang, Le Kang

Journal: Sci Adv

PubMed ID: 37611100

Doi: 10.1126/sciadv.adi5168

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Redox-Responsive Phase-Separating Peptide as a Universal Delivery Vehicle for CRISPR/Cas9 Genome Editing Machinery

Authors: Yue Sun, Xiaojie Xu, Liwei Chen, Wei Leong Chew, Yuan Ping, Ali Miserez

Journal: ACS Nano

PubMed ID: 37584415

Doi: 10.1021/acsnano.3c02669

Products & Services: Proteins, Expression, Isolation and Analysis

Amyloidogenic propensity of self-assembling peptides and their adjuvant potential for use as DNA vaccines

Authors: Paresh C Shrimali, Sheng Chen, Anirban Das, Rachel Dreher, Matthew K Howard, Jeremy J Ryan, Jeremy Buck, Darren Kim, Macy L Sprunger, Jai S Rudra, Meredith E Jackrel

Journal: Acta Biomater

PubMed ID: 37586449

Doi: 10.1016/j.actbio.2023.08.015

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Brain-Derived 11S Regulator (PA28αβ) Promotes Proteasomal Hydrolysis of Elongated Oligoglutamine-Containing Peptides

Authors: Viacheslav A Kriachkov, Natalia N Gotmanova, Vadim N Tashlitsky, Anna V Bacheva

Journal: Int J Mol Sci

PubMed ID: 37686081

Doi: 10.3390/ijms241713275

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SARS-CoV-2 fusion peptide sculpting of a membrane with insertion of charged and polar groups

Authors: Steven R Van Doren, Benjamin S Scott, Rama K Koppisetti

Journal: Structure

PubMed ID: 37625399

Doi: 10.1016/j.str.2023.07.015

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Newcastle disease virus (NDV) recombinant expressing Marek's disease virus (MDV) glycoprotein B significantly protects chickens against MDV and NDV challenges

Authors: Lei He, Stephen Spatz, John R Dunn, Qingzhong Yu

Journal: Vaccine

PubMed ID: 37598026

Doi: 10.1016/j.vaccine.2023.08.038

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VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

Authors: Chunsik Lee, Rongyuan Chen, Guangli Sun, Xialin Liu, Xianchai Lin, Chang He, Liying Xing, Lixian Liu, Lasse D Jensen, Anil Kumar, Harald F Langer, Xiangrong Ren, Jianing Zhang, Lijuan Huang, Xiangke Yin, JongKyong Kim, Juanhua Zhu, Guanqun Huang, Jiani Li, Weiwei Lu, Wei Chen, Juanxi Liu, Jiaxin Hu, Qihang Sun, Weisi Lu, Lekun Fang, Shasha Wang, Haiqing Kuang, Yihan Zhang, Geng Tian, Jia Mi, Bi-Ang Kang, Masashi Narazaki, Aaron Prodeus, Luc Schoonjans, David M Ornitz, Jean Gariepy, Guy Eelen, Mieke Dewerchin, Yunlong Yang, Jing-Song Ou, Antonio Mora, Jin Yao, Chen Zhao, Yizhi Liu, Peter Carmeliet, Yihai Cao, Xuri Li

Journal: Signal Transduct Target Ther

PubMed ID: 37591843

Doi: 10.1038/s41392-023-01539-9

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Rapid and Sensitive Diagnosis of Leber Hereditary Optic Neuropathy Variants Using CRISPR/Cas12a Detection

Authors: Xiaoling Wan, Jieqiong Chen, Yidong Wu, Zhixuan Chen, Yin Liu, Tong Li, Junran Sun, Ting Zhang, Fuling Zhou, Xingxu Huang, Yang Li, Xinjie Wang, Xiaodong Sun

Journal: J Mol Diagn

PubMed ID: 37517824

Doi: 10.1016/j.jmoldx.2023.04.006

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Immunogenicity of Mix-and-Match CoronaVac/BNT162b2 Regimen versus Homologous CoronaVac/CoronaVac Vaccination: A Single-Blinded, Randomized, Parallel Group Superiority Trial

Authors: Samar Samoud, Jihene Bettaieb, Mariem Gdoura, Ghassen Kharroubi, Feriel Ben Ghachem, Imen Zamali, Ahlem Ben Hmid, Sadok Salem, Ahmed Adel Gereisha, Mongi Dellagi, Nahed Hogga, Adel Gharbi, Amor Baccouche, Manel Gharbi, Chadha Khemissi, Ghada Akili, Wissem Slama, Nabila Chaieb, Yousr Galai, Hechmi Louzir, Henda Triki, Melika Ben Ahmed

Journal: Vaccines (Basel)

PubMed ID: 37631897

Doi: 10.3390/vaccines11081329

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Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily

Authors: Fenglian Liu, Yu Dang, Lu Li, Hao Feng, Jianlin Li, Haowei Wang, Xu Zhang, Zhe Zhang, Sheng Ye, Yutao Tian, Qingfeng Chen

Journal: Nat Chem Biol

PubMed ID: 37550431

Doi: 10.1038/s41589-023-01401-7

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Intracerebral Hemorrhage-Induced Brain Injury: the Role of Lysosomal-Associated Transmembrane Protein 5

Authors: Wei Hua, Shuainan Ma, Yuxin Pang, Qi Liu, Yueying Wang, Zhiyi Liu, Nan Zhao, Naixin Ren, Sinan Jin, Benshuai Wang, Yuejia Song, Jiping Qi

Journal: Mol Neurobiol

PubMed ID: 37525083

Doi: 10.1007/s12035-023-03484-8

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Photoexcited cryptochromes interact with ADA2b and SMC5 to promote the repair of DNA double-strand breaks in Arabidopsis

Authors: Tongtong Guo, Minqing Liu, Li Chen, Yao Liu, Ling Li, Yupeng Li, Xiaoli Cao, Zhilei Mao, Wenxiu Wang, Hong-Quan Yang

Journal: Nat Plants

PubMed ID: 37488265

Doi: 10.1038/s41477-023-01461-6

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Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4 T cells

Authors: Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Christina M Monnie, Muhammad S Alam, Ming Zhou, Melissa Mikolaj, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D Ashwell, Klaus Strebel, Kyung S Lee

Journal: Res Sq

PubMed ID: 37645926

Doi: 10.21203/rs.3.rs-2924123/v1

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Vav1-dependent Rac1 activation mediates hypoxia-induced gemcitabine resistance in pancreatic ductal adenocarcinoma cells through upregulation of HIF-1α expression

Authors: Congyuan Zhu, Hao Hu, Ye Ma, Shuming Xiong, Dongming Zhu

Journal: Cell Biol Int

PubMed ID: 37545183

Doi: 10.1002/cbin.12074

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Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2

Authors: Shangyu Yang , Yong Wang , Feiyang Yu , Rao Cheng , Yiwei Zhang , Dan Zhou , Xuanxiu Ren , Zengqin Deng , Haiyan Zhao

Journal: Nature Communications

PubMed ID: 37626059

Doi: 10.1038/s41467-023-40748-2

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Secreted Peptide SpPIP1 Modulates Disease Resistance and Salt Tolerance in Tomato

Authors: Ruirui Yang , Zhicheng Wang , Lei Zhao , Jie Liu , Jun Meng , Yushi Luan

Journal: J Agric Food Chem .

PubMed ID: 37535837

Doi: 10.1021/acs.jafc.3c03412

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Homozygous COQ7 mutation: a new cause of potentially treatable distal hereditary motor neuropathy

Authors: Arnaud Jacquier, Julian Theuriet, Fanny Fontaine, Valentine Mosbach, Nicolas Lacoste, Shams Ribault, Valérie Risson, Julien Carras, Laurent Coudert, Thomas Simonet, Philippe Latour, Tanya Stojkovic, Juliette Piard, Anne Cosson, Gaëtan Lesca, Françoise Bouhour, Stéphane Allouche, Hélène Puccio, Antoine Pegat, Laurent Schaeffer

Journal: Brain

PubMed ID: 36454683

Doi: 10.1093/brain/awac453

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Microbe-induced gene silencing boosts crop protection against soil-borne fungal pathogens

Authors: Han-Guang Wen, Jian-Hua Zhao, Bo-Sen Zhang, Feng Gao, Xue-Ming Wu, Yong-Sheng Yan, Jie Zhang, Hui-Shan Guo

Journal: Nat Plants

PubMed ID: 37653339

Doi: 10.1038/s41477-023-01507-9

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Organelle-dependent polyprotein designs enable stoichiometric expression of nitrogen fixation components targeted to mitochondria

Authors: Jianguo Yang, Nan Xiang, Yiheng Liu, Chenyue Guo, Chenyu Li, Hui Li, Shuyi Cai, Ray Dixon, Yi-Ping Wang

Journal: Proc Natl Acad Sci U S A

PubMed ID: 37585462

Doi: 10.1073/pnas.2305142120

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GmNAC039 and GmNAC018 activate the expression of cysteine protease genes to promote soybean nodule senescence

Authors: Haixiang Yu, Aifang Xiao, Jiashan Wu, Haoxing Li, Yan Duan, Qingshan Chen, Hui Zhu, Yangrong Cao

Journal: Plant Cell

PubMed ID: 37177994

Doi: 10.1093/plcell/koad129

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Design, synthesis and evaluation of ursodeoxycholic acid-cinnamic acid hybrids as potential anti-inflammatory agents by inhibiting Akt/NF-κB and MAPK signaling pathways

Authors: Xiaoxue Li, Yue Hu, Bingxin He, Lingyu Li, Yu Tian, Yingjie Xiao, Hai Shang, Zhongmei Zou

Journal: Eur J Med Chem

PubMed ID: 37678142

Doi: 10.1016/j.ejmech.2023.115785

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In Vitro and Ex Planta Gold-Bonded and Gold-Mineralized Tobacco Mosaic Virus

Authors: Yifeng Ma, Zhuohong Wu, Nicole F Steinmetz

Journal: Langmuir

PubMed ID: 37540623

Doi: 10.1021/acs.langmuir.3c00688

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Structure/epitope analysis and IgE binding activities of three cyclophilin family proteins from Dermatophagoides pteronyssinus

Authors: Yuwei Li, Xizhuo Sun, Liteng Yang

Journal: Sci Rep

PubMed ID: 37604978

Doi: 10.1038/s41598-023-40720-6

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Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity

Authors: Erdem Aybay, Mamoun Elkhalifa, Srinivas Akula, Sara Wernersson, Lars Hellman

Journal: Dev Comp Immunol

PubMed ID: 37597699

Doi: 10.1016/j.dci.2023.104920

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Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis

Authors: Shihao Xie , Jiaxin Li , Fengyuan Lyu , Qingming Xiong , Peng Gu , Yuqi Chen , Meiling Chen , Jingna Bao , Xianglong Zhang , Rongjuan Wei , Youpeng Deng , Hongzheng Wang , Zhenhua Zeng , Zhongqing Chen , Yongqiang Deng , Zhuoshi Lian , Jie Zhao , Wei Gong , Ye Chen , Ke-Xuan Liu , Yi Duan , Yong Jiang , Hong-Wei Zhou , Peng Chen

Journal: Gut .

PubMed ID: 37553229

Doi: 10.1136/gutjnl-2023-329996

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Crystal structure of domain of unknown function 507 (DUF507) reveals a new protein fold

Authors: Cole E McKay , Jianlin Cheng , John J Tanner

Journal: Sci Rep .

PubMed ID: 37596303

Doi: 10.1038/s41598-023-40558-y

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SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression

Authors: Nuno Bastos, Stéphanie A Castaldo, Bárbara Adem, José C Machado, Carlos A Melo, Sonia A Melo

Journal: J Transl Med

PubMed ID: 37641131

Doi: 10.1186/s12967-023-04448-1

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TRIB1 confers therapeutic resistance in GBM cells by activating the ERK and Akt pathways

Authors: Karnika Singh, Chunhua Han, Jessica L Fleming, Aline P Becker, Joseph McElroy, Tiantian Cui, Benjamin Johnson, Ashok Kumar, Ebin Sebastian, Christian A Showalter, Morgan S Schrock, Matthew K Summers, Valesio Becker, Zhen-Yue Tong, Xiaomei Meng, Heather R Manring, Monica Venere, Erica H Bell, Pierre A Robe, A L Grosu, S Jaharul Haque, Arnab Chakravarti

Journal: Sci Rep

PubMed ID: 37528172

Doi: 10.1038/s41598-023-32983-w

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Effectiveness of Bivalent Omicron-Containing Booster Vaccines against SARS-CoV-2 Omicron Variant among Individuals with and without Prior SARS-CoV-2 Infection

Authors: Kristin Widyasari, Jieun Jang, Taejoon Kang, Sunjoo Kim

Journal: Viruses

PubMed ID: 37632098

Doi: 10.3390/v15081756

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mRNA vaccination boosts S-specific T cell memory and promotes expansion of CD45RA T-like CD8 T cells in COVID-19 recovered individuals

Authors: Koshlan Mayer-Blackwell, Heeju Ryu, Amy S Codd, K Rachael Parks, Hugh R MacMillan, Kristen W Cohen, Terri L Stewart, Aaron Seese, Maria P Lemos, Stephen C De Rosa, Julie L Czartoski, Zoe Moodie, Long T Nguyen, Donald J McGuire, Rafi Ahmed, Andrew Fiore-Gartland, M Juliana McElrath, Evan W Newell

Journal: Cell Rep Med

PubMed ID: 37552991

Doi: 10.1016/j.xcrm.2023.101149

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Anti-Melanogenic and Antioxidant Activity of Bifidobacterium longum Strain ZJ1 Extracts, Isolated from a Chinese Centenarian

Authors: Jing Wu , Funa Zhang , Haixia Yu , Shimei Qi , Yu Wu , Weihua Xiao

Journal: Int J Mol Sci .

PubMed ID: 37628988

Doi: 10.3390/ijms241612810

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Author Correction: mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum

Authors: Clifford T H Hayashi, Yi Cao, Leor C Clark, Abhai K Tripathi, Fidel Zavala, Garima Dwivedi, James Knox, Mohamad-Gabriel Alameh, Paulo J C Lin, Ying K Tam, Drew Weissman, Nirbhay Kumar

Journal: npj Vaccines

PubMed ID: 37567884

Doi: 10.1038/s41541-023-00723-w

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Inactivation influences the extent of inhibition of voltage-gated Ca channels by Gem-implications for channelopathies

Authors: Salma Allam, Rose Levenson-Palmer, Zuleen Chia Chang, Sukhjinder Kaur, Bryan Cernuda, Ananya Raman, Audrey Booth, Scott Dobbins, Gabrielle Suppa, Jian Yang, Zafir Buraei

Journal: Front Physiol

PubMed ID: 37654674

Doi: 10.3389/fphys.2023.1155976

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Publisher Correction: High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation

Authors: Brooke D Huisman, Ning Guan, Timo Rückert, Lee Garner, Nishant K Singh, Andrew J McMichael, Geraldine M Gillespie, Chiara Romagnani, Michael E Birnbaum

Journal: Nat Commun

PubMed ID: 37644057

Doi: 10.1038/s41467-023-40946-y

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Vaccination with the Crimean-Congo hemorrhagic fever virus viral replicon vaccine induces NP-based T-cell activation and antibodies possessing Fc-mediated effector functions

Authors: F E M Scholte, E Karaaslan, T J O'Neal, T E Sorvillo, S C Genzer, S R Welch, J D Coleman-McCray, J R Spengler, M H Kainulainen, J M Montgomery, S D Pegan, E Bergeron, C F Spiropoulou

Journal: Front Cell Infect Microbiol

PubMed ID: 37671145

Doi: 10.3389/fcimb.2023.1233148

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Recombinant spike protein vaccines coupled with adjuvants that have different modes of action induce protective immunity against SARS-CoV-2

Authors: Shiho Chiba, Peter J Halfmann, Shun Iida, Yuichiro Hirata, Yuko Sato, Makoto Kuroda, Tammy Armbrust, Samuel Spyra, Tadaki Suzuki, Yoshihiro Kawaoka

Journal: Vaccine

PubMed ID: 37635002

Doi: 10.1016/j.vaccine.2023.08.054

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Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages

Authors: Congjing Wang, Meng Xi Chen, Yuan Zhang, Xue Bai, Qiqi Cao, Jian Han, Nana Zhang, Chun Zhao, Xiufeng Ling, Ximan Rui, Yichun Guan, Junqiang Zhang, Ran Huo

Journal: J Ovarian Res

PubMed ID: 37635245

Doi: 10.1186/s13048-023-01229-8

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Riding the Omicron BA5 Wave: Improved Humoral Response after Vaccination with Bivalent Omicron BA4-5-Adapted mRNA SARS-CoV-2 Vaccine in Chronic Hemodialysis Patients

Authors: Eugen Ovcar, Sammy Patyna, Niko Kohmer, Elisabeth Heckel-Kratz, Sandra Ciesek, Holger F Rabenau, Ingeborg A Hauser, Kirsten de Groot

Journal: Vaccines (Basel)

PubMed ID: 37766105

Doi: 10.3390/vaccines11091428

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RhoB promotes Salmonella survival by regulating autophagy

Authors: Marco Kirchenwitz, Jessica Halfen, Kristin von Peinen, Silvia Prettin, Jana Kollasser, Susanne Zur Lage, Wulf Blankenfeldt, Cord Brakebusch, Klemens Rottner, Anika Steffen, Theresia E B Stradal

Journal: Eur J Cell Biol

PubMed ID: 37703749

Doi: 10.1016/j.ejcb.2023.151358

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Optimization and Deoptimization of Codons in SARS-CoV-2 and Related Implications for Vaccine Development

Authors: Xinkai Wu, Ke-Jia Shan, Fuwen Zan, Xiaolu Tang, Zhaohui Qian, Jian Lu

Journal: Adv Sci (Weinh) .

PubMed ID: 37267926

Doi: 10.3390/v16020223

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Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer

Authors: Jian Chen, Tianchuan Zhu, Guanmin Jiang, Qi Zeng, Zhijian Li, Xi Huang

Journal: Mol Cancer

PubMed ID: 37563723

Doi: 10.1186/s12943-023-01830-x

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Development of a novel ultrasound- and biocrosslinking-enhanced immobilization strategy with application to food enzymes

Authors: Juan Han , Ting Zhang , Zhuoyue Zhou , Houjin Zhang

Journal: Food Chem .

PubMed ID: 36917903

Doi: 10.1016/j.foodchem.2023.135810

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Immunogenicity, safety and reactogenicity of heterologous (third dose) booster vaccination with a full or fractional dose of two different COVID-19 vaccines: A phase 4, single-blind, randomized controlled trial in adults

Authors: Sue Ann Costa Clemens, Natalie Marchevsky, Sarah Kelly, Sally Felle, Ahmed Eldawi, Rupetha Rajasingam, Rawan Mahmud, Teresa Lambe, Merryn Voysey, Isabela Gonzalez, Eveline Pipolo Milan, Maria Cleonice Justino, Sagida Bibi, Parvinder Aley, Ralf Clemens, Andrew J Pollard

Journal: Hum Vaccin Immunother

PubMed ID: 37438960

Doi: 10.1080/21645515.2023.2233400

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Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1

Authors: Jonathan F Thomas, Marco Igor Valencia-Sánchez, Simone Tamburri, Susan L Gloor, Samantha Rustichelli, Victoria Godínez-López, Pablo De Ioannes, Rachel Lee, Stephen Abini-Agbomson, Kristjan Gretarsson, Jonathan M Burg, Allison R Hickman, Lu Sun, Saarang Gopinath, Hailey F Taylor, Zu-Wen Sun, Ryan J Ezell, Anup Vaidya, Matthew J Meiners, Marcus A Cheek, William J Rice, Vladimir Svetlov, Evgeny Nudler, Chao Lu, Michael-Christopher Keogh, Diego Pasini, Karim-Jean Armache

Journal: Sci Adv

PubMed ID: 37556531

Doi: 10.1126/sciadv.adg9832

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Photoaffinity labelling displacement assay using multiple recombinant protein domains

Authors: David J Fallon, Alex Phillipou, Christopher J Schofield, David House, Nicholas C O Tomkinson, Jacob T Bush

Journal: Biochem J

PubMed ID: 37401534

Doi: 10.1042/BCJ20230129

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SARS-CoV-2 neutralizing antibody bebtelovimab - a systematic scoping review and meta-analysis

Authors: Mabel Nyit Yi Liew, Kok Pim Kua, Shaun Wen Huey Lee, Kon Ken Wong

Journal: Front Immunol

PubMed ID: 37701439

Doi: 10.3389/fimmu.2023.1100263

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Preclinical evaluation of manufacturable SARS-CoV-2 spike virus-like particles produced in Chinese Hamster Ovary cells

Authors: Sergio P Alpuche-Lazcano, Matthew Stuible, Bassel Akache, Anh Tran, John Kelly, Sabahudin Hrapovic, Anna Robotham, Arsalan Haqqani, Alexandra Star, Tyler M Renner, Julie Blouin, Jean-Sébastien Maltais, Brian Cass, Kai Cui, Jae-Young Cho, Xinyu Wang, Daria Zoubchenok, Renu Dudani, Diana Duque, Michael J McCluskie, Yves Durocher

Journal: Commun Med (Lond)

PubMed ID: 37612423

Doi: 10.1038/s43856-023-00340-7

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Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery

Authors: Magdalena M Żak, Keerat Kaur, Jimeen Yoo, Ann Anu Kurian, Matthew Adjmi, Gayatri Mainkar, Seonghun Yoon, Lior Zangi

Journal: Pharmaceutics

PubMed ID: 37765147

Doi: 10.3390/pharmaceutics15092176

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Divergent Pharmacology and Biased Signaling of the Four Melanocortin-4 Receptor Isoforms in Rainbow Trout ()

Authors: Ren-Lei Ji, Ting Liu, Zhi-Shuai Hou, Hai-Shen Wen, Ya-Xiong Tao

Journal: Biomolecules

PubMed ID: 37627313

Doi: 10.3390/biom13081248

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High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase

Authors: Lu Yang, Tristan Wagner, Ariel Mechaly, Alexandra Boyko, Eduardo M Bruch, Daniela Megrian, Francesca Gubellini, Pedro M Alzari, Marco Bellinzoni

Journal: Nat Commun

PubMed ID: 37563123

Doi: 10.1038/s41467-023-40253-6

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High-throughput functional dissection of noncoding SNPs with biased allelic enhancer activity for insulin resistance-relevant phenotypes

Authors: Yuan-Yuan Duan, Xiao-Feng Chen, Ren-Jie Zhu, Ying-Ying Jia, Xiao-Ting Huang, Meng Zhang, Ning Yang, Shan-Shan Dong, Mengqi Zeng, Zhihui Feng, Dong-Li Zhu, Hao Wu, Feng Jiang, Wei Shi, Wei-Xin Hu, Xin Ke, Hao Chen, Yunlong Liu, Rui-Hua Jing, Yan Guo, Meng Li, Tie-Lin Yang

Journal: Am J Hum Genet

PubMed ID: 37506691

Doi: 10.1016/j.ajhg.2023.07.002

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