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Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily

Authors: Fenglian Liu, Yu Dang, Lu Li, Hao Feng, Jianlin Li, Haowei Wang, Xu Zhang, Zhe Zhang, Sheng Ye, Yutao Tian, Qingfeng Chen

Journal: Nat Chem Biol

PubMed ID: 37550431

Doi: 10.1038/s41589-023-01401-7

Products & Services: Peptide Synthesis

Intracerebral Hemorrhage-Induced Brain Injury: the Role of Lysosomal-Associated Transmembrane Protein 5

Authors: Wei Hua, Shuainan Ma, Yuxin Pang, Qi Liu, Yueying Wang, Zhiyi Liu, Nan Zhao, Naixin Ren, Sinan Jin, Benshuai Wang, Yuejia Song, Jiping Qi

Journal: Mol Neurobiol

PubMed ID: 37525083

Doi: 10.1007/s12035-023-03484-8

Products & Services: Molecular Biology Reagents

Photoexcited cryptochromes interact with ADA2b and SMC5 to promote the repair of DNA double-strand breaks in Arabidopsis

Authors: Tongtong Guo, Minqing Liu, Li Chen, Yao Liu, Ling Li, Yupeng Li, Xiaoli Cao, Zhilei Mao, Wenxiu Wang, Hong-Quan Yang

Journal: Nat Plants

PubMed ID: 37488265

Doi: 10.1038/s41477-023-01461-6

Products & Services: Proteins, Expression, Isolation and Analysis

Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4 T cells

Authors: Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Christina M Monnie, Muhammad S Alam, Ming Zhou, Melissa Mikolaj, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D Ashwell, Klaus Strebel, Kyung S Lee

Journal: Res Sq

PubMed ID: 37645926

Doi: 10.21203/rs.3.rs-2924123/v1

Products & Services: DNA Sequencing

Vav1-dependent Rac1 activation mediates hypoxia-induced gemcitabine resistance in pancreatic ductal adenocarcinoma cells through upregulation of HIF-1α expression

Authors: Congyuan Zhu, Hao Hu, Ye Ma, Shuming Xiong, Dongming Zhu

Journal: Cell Biol Int

PubMed ID: 37545183

Doi: 10.1002/cbin.12074

Products & Services: Molecular Biology Reagents

Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2

Authors: Shangyu Yang , Yong Wang , Feiyang Yu , Rao Cheng , Yiwei Zhang , Dan Zhou , Xuanxiu Ren , Zengqin Deng , Haiyan Zhao

Journal: Nature Communications

PubMed ID: 37626059

Doi: 10.1038/s41467-023-40748-2

Products & Services: Proteins, Expression, Isolation and Analysis

Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis

Authors: Shihao Xie , Jiaxin Li , Fengyuan Lyu , Qingming Xiong , Peng Gu , Yuqi Chen , Meiling Chen , Jingna Bao , Xianglong Zhang , Rongjuan Wei , Youpeng Deng , Hongzheng Wang , Zhenhua Zeng , Zhongqing Chen , Yongqiang Deng , Zhuoshi Lian , Jie Zhao , Wei Gong , Ye Chen , Ke-Xuan Liu , Yi Duan , Yong Jiang , Hong-Wei Zhou , Peng Chen

Journal: Gut .

PubMed ID: 37553229

Doi: 10.1136/gutjnl-2023-329996

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Crystal structure of domain of unknown function 507 (DUF507) reveals a new protein fold

Authors: Cole E McKay , Jianlin Cheng , John J Tanner

Journal: Sci Rep .

PubMed ID: 37596303

Doi: 10.1038/s41598-023-40558-y

Products & Services: Gene Synthesis

Author Correction: mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum

Authors: Clifford T H Hayashi, Yi Cao, Leor C Clark, Abhai K Tripathi, Fidel Zavala, Garima Dwivedi, James Knox, Mohamad-Gabriel Alameh, Paulo J C Lin, Ying K Tam, Drew Weissman, Nirbhay Kumar

Journal: npj Vaccines

PubMed ID: 37567884

Doi: 10.1038/s41541-023-00723-w

Products & Services: Molecular Biology Reagents

Structure/epitope analysis and IgE binding activities of three cyclophilin family proteins from Dermatophagoides pteronyssinus

Authors: Yuwei Li, Xizhuo Sun, Liteng Yang

Journal: Sci Rep

PubMed ID: 37604978

Doi: 10.1038/s41598-023-40720-6

Products & Services: Molecular Biology Reagents

Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity

Authors: Erdem Aybay, Mamoun Elkhalifa, Srinivas Akula, Sara Wernersson, Lars Hellman

Journal: Dev Comp Immunol

PubMed ID: 37597699

Doi: 10.1016/j.dci.2023.104920

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SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression

Authors: Nuno Bastos, Stéphanie A Castaldo, Bárbara Adem, José C Machado, Carlos A Melo, Sonia A Melo

Journal: J Transl Med

PubMed ID: 37641131

Doi: 10.1186/s12967-023-04448-1

Products & Services: Molecular Biology Reagents

TRIB1 confers therapeutic resistance in GBM cells by activating the ERK and Akt pathways

Authors: Karnika Singh, Chunhua Han, Jessica L Fleming, Aline P Becker, Joseph McElroy, Tiantian Cui, Benjamin Johnson, Ashok Kumar, Ebin Sebastian, Christian A Showalter, Morgan S Schrock, Matthew K Summers, Valesio Becker, Zhen-Yue Tong, Xiaomei Meng, Heather R Manring, Monica Venere, Erica H Bell, Pierre A Robe, A L Grosu, S Jaharul Haque, Arnab Chakravarti

Journal: Sci Rep

PubMed ID: 37528172

Doi: 10.1038/s41598-023-32983-w

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Organelle-dependent polyprotein designs enable stoichiometric expression of nitrogen fixation components targeted to mitochondria

Authors: Jianguo Yang, Nan Xiang, Yiheng Liu, Chenyue Guo, Chenyu Li, Hui Li, Shuyi Cai, Ray Dixon, Yi-Ping Wang

Journal: Proc Natl Acad Sci U S A

PubMed ID: 37585462

Doi: 10.1073/pnas.2305142120

Products & Services: Gene Synthesis

Secreted Peptide SpPIP1 Modulates Disease Resistance and Salt Tolerance in Tomato

Authors: Ruirui Yang , Zhicheng Wang , Lei Zhao , Jie Liu , Jun Meng , Yushi Luan

Journal: J Agric Food Chem .

PubMed ID: 37535837

Doi: 10.1021/acs.jafc.3c03412

Products & Services: Peptide Synthesis

Inactivation influences the extent of inhibition of voltage-gated Ca channels by Gem-implications for channelopathies

Authors: Salma Allam, Rose Levenson-Palmer, Zuleen Chia Chang, Sukhjinder Kaur, Bryan Cernuda, Ananya Raman, Audrey Booth, Scott Dobbins, Gabrielle Suppa, Jian Yang, Zafir Buraei

Journal: Front Physiol

PubMed ID: 37654674

Doi: 10.3389/fphys.2023.1155976

Products & Services: Proteins, Expression, Isolation and Analysis

In Vitro and Ex Planta Gold-Bonded and Gold-Mineralized Tobacco Mosaic Virus

Authors: Yifeng Ma, Zhuohong Wu, Nicole F Steinmetz

Journal: Langmuir

PubMed ID: 37540623

Doi: 10.1021/acs.langmuir.3c00688

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Vaccination with the Crimean-Congo hemorrhagic fever virus viral replicon vaccine induces NP-based T-cell activation and antibodies possessing Fc-mediated effector functions

Authors: F E M Scholte, E Karaaslan, T J O'Neal, T E Sorvillo, S C Genzer, S R Welch, J D Coleman-McCray, J R Spengler, M H Kainulainen, J M Montgomery, S D Pegan, E Bergeron, C F Spiropoulou

Journal: Front Cell Infect Microbiol

PubMed ID: 37671145

Doi: 10.3389/fcimb.2023.1233148

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Riding the Omicron BA5 Wave: Improved Humoral Response after Vaccination with Bivalent Omicron BA4-5-Adapted mRNA SARS-CoV-2 Vaccine in Chronic Hemodialysis Patients

Authors: Eugen Ovcar, Sammy Patyna, Niko Kohmer, Elisabeth Heckel-Kratz, Sandra Ciesek, Holger F Rabenau, Ingeborg A Hauser, Kirsten de Groot

Journal: Vaccines (Basel)

PubMed ID: 37766105

Doi: 10.3390/vaccines11091428

Products & Services: Molecular Biology Reagents

Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages

Authors: Congjing Wang, Meng Xi Chen, Yuan Zhang, Xue Bai, Qiqi Cao, Jian Han, Nana Zhang, Chun Zhao, Xiufeng Ling, Ximan Rui, Yichun Guan, Junqiang Zhang, Ran Huo

Journal: J Ovarian Res

PubMed ID: 37635245

Doi: 10.1186/s13048-023-01229-8

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mRNA vaccination boosts S-specific T cell memory and promotes expansion of CD45RA T-like CD8 T cells in COVID-19 recovered individuals

Authors: Koshlan Mayer-Blackwell, Heeju Ryu, Amy S Codd, K Rachael Parks, Hugh R MacMillan, Kristen W Cohen, Terri L Stewart, Aaron Seese, Maria P Lemos, Stephen C De Rosa, Julie L Czartoski, Zoe Moodie, Long T Nguyen, Donald J McGuire, Rafi Ahmed, Andrew Fiore-Gartland, M Juliana McElrath, Evan W Newell

Journal: Cell Rep Med

PubMed ID: 37552991

Doi: 10.1016/j.xcrm.2023.101149

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Development of a novel ultrasound- and biocrosslinking-enhanced immobilization strategy with application to food enzymes

Authors: Juan Han , Ting Zhang , Zhuoyue Zhou , Houjin Zhang

Journal: Food Chem .

PubMed ID: 36917903

Doi: 10.1016/j.foodchem.2023.135810

Products & Services: Proteins, Expression, Isolation and Analysis

Publisher Correction: High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation

Authors: Brooke D Huisman, Ning Guan, Timo Rückert, Lee Garner, Nishant K Singh, Andrew J McMichael, Geraldine M Gillespie, Chiara Romagnani, Michael E Birnbaum

Journal: Nat Commun

PubMed ID: 37644057

Doi: 10.1038/s41467-023-40946-y

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Microbe-induced gene silencing boosts crop protection against soil-borne fungal pathogens

Authors: Han-Guang Wen, Jian-Hua Zhao, Bo-Sen Zhang, Feng Gao, Xue-Ming Wu, Yong-Sheng Yan, Jie Zhang, Hui-Shan Guo

Journal: Nat Plants

PubMed ID: 37653339

Doi: 10.1038/s41477-023-01507-9

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Effectiveness of Bivalent Omicron-Containing Booster Vaccines against SARS-CoV-2 Omicron Variant among Individuals with and without Prior SARS-CoV-2 Infection

Authors: Kristin Widyasari, Jieun Jang, Taejoon Kang, Sunjoo Kim

Journal: Viruses

PubMed ID: 37632098

Doi: 10.3390/v15081756

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RhoB promotes Salmonella survival by regulating autophagy

Authors: Marco Kirchenwitz, Jessica Halfen, Kristin von Peinen, Silvia Prettin, Jana Kollasser, Susanne Zur Lage, Wulf Blankenfeldt, Cord Brakebusch, Klemens Rottner, Anika Steffen, Theresia E B Stradal

Journal: Eur J Cell Biol

PubMed ID: 37703749

Doi: 10.1016/j.ejcb.2023.151358

Products & Services: Proteins, Expression, Isolation and Analysis

GmNAC039 and GmNAC018 activate the expression of cysteine protease genes to promote soybean nodule senescence

Authors: Haixiang Yu, Aifang Xiao, Jiashan Wu, Haoxing Li, Yan Duan, Qingshan Chen, Hui Zhu, Yangrong Cao

Journal: Plant Cell

PubMed ID: 37177994

Doi: 10.1093/plcell/koad129

Products & Services: Proteins, Expression, Isolation and Analysis

Anti-Melanogenic and Antioxidant Activity of Bifidobacterium longum Strain ZJ1 Extracts, Isolated from a Chinese Centenarian

Authors: Jing Wu , Funa Zhang , Haixia Yu , Shimei Qi , Yu Wu , Weihua Xiao

Journal: Int J Mol Sci .

PubMed ID: 37628988

Doi: 10.3390/ijms241612810

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Design, synthesis and evaluation of ursodeoxycholic acid-cinnamic acid hybrids as potential anti-inflammatory agents by inhibiting Akt/NF-κB and MAPK signaling pathways

Authors: Xiaoxue Li, Yue Hu, Bingxin He, Lingyu Li, Yu Tian, Yingjie Xiao, Hai Shang, Zhongmei Zou

Journal: Eur J Med Chem

PubMed ID: 37678142

Doi: 10.1016/j.ejmech.2023.115785

Products & Services: Proteins, Expression, Isolation and Analysis

Recombinant spike protein vaccines coupled with adjuvants that have different modes of action induce protective immunity against SARS-CoV-2

Authors: Shiho Chiba, Peter J Halfmann, Shun Iida, Yuichiro Hirata, Yuko Sato, Makoto Kuroda, Tammy Armbrust, Samuel Spyra, Tadaki Suzuki, Yoshihiro Kawaoka

Journal: Vaccine

PubMed ID: 37635002

Doi: 10.1016/j.vaccine.2023.08.054

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Homozygous COQ7 mutation: a new cause of potentially treatable distal hereditary motor neuropathy

Authors: Arnaud Jacquier, Julian Theuriet, Fanny Fontaine, Valentine Mosbach, Nicolas Lacoste, Shams Ribault, Valérie Risson, Julien Carras, Laurent Coudert, Thomas Simonet, Philippe Latour, Tanya Stojkovic, Juliette Piard, Anne Cosson, Gaëtan Lesca, Françoise Bouhour, Stéphane Allouche, Hélène Puccio, Antoine Pegat, Laurent Schaeffer

Journal: Brain

PubMed ID: 36454683

Doi: 10.1093/brain/awac453

Products & Services: Gene Synthesis

Optimization and Deoptimization of Codons in SARS-CoV-2 and Related Implications for Vaccine Development

Authors: Xinkai Wu, Ke-Jia Shan, Fuwen Zan, Xiaolu Tang, Zhaohui Qian, Jian Lu

Journal: Adv Sci (Weinh) .

PubMed ID: 37267926

Doi: 10.3390/v16020223

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Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer

Authors: Jian Chen, Tianchuan Zhu, Guanmin Jiang, Qi Zeng, Zhijian Li, Xi Huang

Journal: Mol Cancer

PubMed ID: 37563723

Doi: 10.1186/s12943-023-01830-x

Products & Services: Gene Synthesis

Immunogenicity, safety and reactogenicity of heterologous (third dose) booster vaccination with a full or fractional dose of two different COVID-19 vaccines: A phase 4, single-blind, randomized controlled trial in adults

Authors: Sue Ann Costa Clemens, Natalie Marchevsky, Sarah Kelly, Sally Felle, Ahmed Eldawi, Rupetha Rajasingam, Rawan Mahmud, Teresa Lambe, Merryn Voysey, Isabela Gonzalez, Eveline Pipolo Milan, Maria Cleonice Justino, Sagida Bibi, Parvinder Aley, Ralf Clemens, Andrew J Pollard

Journal: Hum Vaccin Immunother

PubMed ID: 37438960

Doi: 10.1080/21645515.2023.2233400

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1

Authors: Jonathan F Thomas, Marco Igor Valencia-Sánchez, Simone Tamburri, Susan L Gloor, Samantha Rustichelli, Victoria Godínez-López, Pablo De Ioannes, Rachel Lee, Stephen Abini-Agbomson, Kristjan Gretarsson, Jonathan M Burg, Allison R Hickman, Lu Sun, Saarang Gopinath, Hailey F Taylor, Zu-Wen Sun, Ryan J Ezell, Anup Vaidya, Matthew J Meiners, Marcus A Cheek, William J Rice, Vladimir Svetlov, Evgeny Nudler, Chao Lu, Michael-Christopher Keogh, Diego Pasini, Karim-Jean Armache

Journal: Sci Adv

PubMed ID: 37556531

Doi: 10.1126/sciadv.adg9832

Products & Services: Proteins, Expression, Isolation and Analysis

Photoaffinity labelling displacement assay using multiple recombinant protein domains

Authors: David J Fallon, Alex Phillipou, Christopher J Schofield, David House, Nicholas C O Tomkinson, Jacob T Bush

Journal: Biochem J

PubMed ID: 37401534

Doi: 10.1042/BCJ20230129

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 neutralizing antibody bebtelovimab - a systematic scoping review and meta-analysis

Authors: Mabel Nyit Yi Liew, Kok Pim Kua, Shaun Wen Huey Lee, Kon Ken Wong

Journal: Front Immunol

PubMed ID: 37701439

Doi: 10.3389/fimmu.2023.1100263

Products & Services: Molecular Biology Reagents

Preclinical evaluation of manufacturable SARS-CoV-2 spike virus-like particles produced in Chinese Hamster Ovary cells

Authors: Sergio P Alpuche-Lazcano, Matthew Stuible, Bassel Akache, Anh Tran, John Kelly, Sabahudin Hrapovic, Anna Robotham, Arsalan Haqqani, Alexandra Star, Tyler M Renner, Julie Blouin, Jean-Sébastien Maltais, Brian Cass, Kai Cui, Jae-Young Cho, Xinyu Wang, Daria Zoubchenok, Renu Dudani, Diana Duque, Michael J McCluskie, Yves Durocher

Journal: Commun Med (Lond)

PubMed ID: 37612423

Doi: 10.1038/s43856-023-00340-7

Products & Services: Proteins, Expression, Isolation and Analysis

Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery

Authors: Magdalena M Żak, Keerat Kaur, Jimeen Yoo, Ann Anu Kurian, Matthew Adjmi, Gayatri Mainkar, Seonghun Yoon, Lior Zangi

Journal: Pharmaceutics

PubMed ID: 37765147

Doi: 10.3390/pharmaceutics15092176

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Divergent Pharmacology and Biased Signaling of the Four Melanocortin-4 Receptor Isoforms in Rainbow Trout ()

Authors: Ren-Lei Ji, Ting Liu, Zhi-Shuai Hou, Hai-Shen Wen, Ya-Xiong Tao

Journal: Biomolecules

PubMed ID: 37627313

Doi: 10.3390/biom13081248

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High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase

Authors: Lu Yang, Tristan Wagner, Ariel Mechaly, Alexandra Boyko, Eduardo M Bruch, Daniela Megrian, Francesca Gubellini, Pedro M Alzari, Marco Bellinzoni

Journal: Nat Commun

PubMed ID: 37563123

Doi: 10.1038/s41467-023-40253-6

Products & Services: Proteins, Expression, Isolation and Analysis

High-throughput functional dissection of noncoding SNPs with biased allelic enhancer activity for insulin resistance-relevant phenotypes

Authors: Yuan-Yuan Duan, Xiao-Feng Chen, Ren-Jie Zhu, Ying-Ying Jia, Xiao-Ting Huang, Meng Zhang, Ning Yang, Shan-Shan Dong, Mengqi Zeng, Zhihui Feng, Dong-Li Zhu, Hao Wu, Feng Jiang, Wei Shi, Wei-Xin Hu, Xin Ke, Hao Chen, Yunlong Liu, Rui-Hua Jing, Yan Guo, Meng Li, Tie-Lin Yang

Journal: Am J Hum Genet

PubMed ID: 37506691

Doi: 10.1016/j.ajhg.2023.07.002

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Identification of sucrose synthase from to favor biocatalytic glycosylation

Authors: Kai Chen, Lei Lin, Ruiqi Ma, Jiajie Ding, Huayi Pan, Yehui Tao, Yan Li, Honghua Jia

Journal: Front Microbiol

PubMed ID: 37649634

Doi: 10.3389/fmicb.2023.1220208

Products & Services: Proteins, Expression, Isolation and Analysis

Conformational investigation of the asymmetric periplasmic domains of LptBFGC using SDSL CW EPR spectroscopy

Authors: Nicholas P Cina, Candice S Klug

Journal: Appl Magn Reson

PubMed ID: 38645307

Doi: 10.1007/s00723-023-01590-3

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GPCR activation and GRK2 assembly by a biased intracellular agonist

Authors: Jia Duan , Heng Liu , Fenghui Zhao , Qingning Yuan , Yujie Ji , Xiaoqing Cai , Xinheng He , Xinzhu Li , Junrui Li , Kai Wu , Tianyu Gao , Shengnan Zhu , Shi Lin , Ming-Wei Wang , Xi Cheng , Wanchao Yin , Yi Jiang , Dehua Yang , H Eric Xu

Journal: Nature .

PubMed ID: 37532940

Doi: 10.1038/s41586-023-06395-9

Products & Services: Proteins, Expression, Isolation and Analysis

A non-toxic recombinant Clostridium septicum α toxin induces protective immunity in mice and rabbits

Authors: Jige Du, Irene Meki, Qianlin Li, Ying Liu, Zhen Zhu, Chenfan Pan, Yingju Xia, Lizhi Fu, Liu Yang, Suhui Zhang, Chunsheng Yin, Yufeng Luo, Tuanjie Wang, Bo Liu, Xiaoyun Chen

Journal: Toxicon

PubMed ID: 37543293

Doi: 10.1016/j.toxicon.2023.107234

Products & Services: Proteins, Expression, Isolation and Analysis

Directed evolution of TetR for constructing sensitive and broad-spectrum tetracycline antibiotics whole-cell biosensor

Authors: Shunlan Li, Dongdong Chen, Ziqing Liu, Shipin Tao, Tianyi Zhang, Yiwen Chen, Lingzhi Bao, Jie Ma, Yuee Huang, Shengmin Xu, Lijun Wu, Shaopeng Chen

Journal: J Hazard Mater

PubMed ID: 37633019

Doi: 10.1016/j.jhazmat.2023.132311

Products & Services: Proteins, Expression, Isolation and Analysis

Directed evolution rice genes with randomly multiplexed sgRNAs assembly of base editors

Authors: Ao Zhang, Tiaofeng Shan, Yan Sun, Zhipeng Chen, Jianjian Hu, Zhichao Hu, Ziheng Ming, Zhitao Zhu, Xue Li, Jun He, Shijia Liu, Ling Jiang, Xiaoou Dong, Yufeng Wu, Yanpeng Wang, Yuqiang Liu, Chao Li, Jianmin Wan

Journal: Plant Biotechnol J

PubMed ID: 37571976

Doi: 10.1111/pbi.14156

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of potential SLA-I-specific T-cell epitopes within the structural proteins of porcine deltacoronavirus

Authors: Yimin Wen, Rui Chen, Junpeng Yang, Enbo Yu, Weizhe Liu, Yijie Liao, Yiping Wen, Rui Wu, Qin Zhao, Senyan Du, Qigui Yan, Xinfeng Han, Sanjie Cao, Xiaobo Huang

Journal: Int J Biol Macromol

PubMed ID: 37579907

Doi: 10.1016/j.ijbiomac.2023.126327

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A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease

Authors: Zhi Zachary Geng, Sandeep Atla, Namir Shaabani, Veerabhadra Vulupala, Kai S Yang, Yugendar R Alugubelli, Kaustav Khatua, Peng-Hsun Chen, Jing Xiao, Lauren R Blankenship, Xinyu R Ma, Erol C Vatansever, Chia-Chuan D Cho, Yuying Ma, Robert Allen, Henry Ji, Shiqing Xu, Wenshe Ray Liu

Journal: J Med Chem

PubMed ID: 37561993

Doi: 10.1021/acs.jmedchem.3c00221

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Structural basis for cross-group recognition of an influenza virus hemagglutinin antibody that targets postfusion stabilized epitope

Authors: Keisuke Tonouchi, Yu Adachi, Tateki Suzuki, Daisuke Kuroda, Ayae Nishiyama, Kohei Yumoto, Haruko Takeyama, Tadaki Suzuki, Takao Hashiguchi, Yoshimasa Takahashi

Journal: PLoS Pathog

PubMed ID: 37556494

Doi: 10.1371/journal.ppat.1011554

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Binding and transport of LPS occurs through the coordinated combination of an array of sites across the entire Escherichia coli LPS transport protein LptA

Authors: Kathryn M Schultz, John R Schneider, Matthew A Fischer, Nicholas P Cina, Molly O Riegert, Dara W Frank, Candice S Klug

Journal: Protein Sci

PubMed ID: 37417889

Doi: 10.1002/pro.4724

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Optimization of an alum-anchored clinical HIV vaccine candidate

Authors: Kristen A Rodrigues, Christopher A Cottrell, Jon M Steichen, Bettina Groschel, Wuhbet Abraham, Heikyung Suh, Yash Agarwal, Kaiyuan Ni, Jason Y H Chang, Parisa Yousefpour, Mariane B Melo, William R Schief, Darrell J Irvine

Journal: npj Vaccines

PubMed ID: 37573422

Doi: 10.1038/s41541-023-00711-0

Products & Services: Recombinant Proteins

Evaluating the effect of food components on the digestion of dietary nucleic acids in human gastric juice in vitro

Authors: Yanfang Zhang, Jingyi Dong, Jingxian Chen, Xiaoming Pan

Journal: Food Sci Nutr

PubMed ID: 37823154

Doi: 10.1002/fsn3.3599

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Toward non-factor therapy in hemophilia: an antithrombin insensitive Gla-domainless factor Xa as tissue factor pathway inhibitor bait

Authors: Marie-Claire Dagher, Atanur Ersayin, Landry Seyve, Mathieu Castellan, Cyril Moreau, Luc Choisnard, Nicole Thielens, Raphaël Marlu, Benoît Polack, Aline Thomas

Journal: Res Pract Thromb Haemost

PubMed ID: 37841511

Doi: 10.1016/j.rpth.2023.102175

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Immobilization of α-transglucosidase on silica-coated magnetic nanoparticles and its application for production of isomaltooligosaccharide from the potato peel

Authors: Rohit Maurya, Usman Ali, Sunaina Kaul, Raja Bhaiyya, Ravindra Pal Singh, Koushik Mazumder

Journal: Sci Rep

PubMed ID: 37543692

Doi: 10.1038/s41598-023-38266-8

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CircMIB2 therapy can effectively treat pathogenic infection by encoding a novel protein

Authors: Weiwei Zheng, Linchao Wang, Shang Geng, Liyuan Yang, Xing Lv, Shiying Xin, Tianjun Xu

Journal: Cell Death Dis

PubMed ID: 37652905

Doi: 10.1038/s41419-023-06105-3

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Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1

Authors: Jun-Qi Luo, Tao-Wei Yang, Jun Wu, Hou-Hua Lai, Li-Bin Zou, Wen-Bin Chen, Xu-Min Zhou, Dao-Jun Lv, Sheng-Ren Cen, Zi-Ning Long, Yi-You Mao, Peng-Xiang Zheng, Xiao-Hong Su, Zhi-Yong Xian, Fang-Peng Shu, Xiang-Ming Mao

Journal: Cell Death Dis

PubMed ID: 37542027

Doi: 10.1038/s41419-023-06007-4

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The SlWRKY6-SlPROPEP-SlPep module confers tomato resistance to Phytophthora infestans

Authors: Ruirui Yang , Jie Liu , Zhicheng Wang , Lei Zhao , Tingting Xue , Jun Meng , Yushi Luan

Journal: Scientia Horticulturae

Doi: 10.1016/j.scienta.2023.112117

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Mechanosensitive accumulation of non-muscle myosin IIB during mitosis requires its translocation activity

Authors: Chao Wang , Jingjing Ding , Qiaodong Wei , Shoukang Du , Xiaobo Gong , Ting Gang Chew

Journal: iScience .

PubMed ID: 37720093

Doi: 10.1016/j.isci.2023.107773

Products & Services: Proteins, Expression, Isolation and Analysis

Using a synthetic machinery to improve carbon yield with acetylphosphate as the core

Authors: Likun Guo , Min Liu , Yujia Bi , Qingsheng Qi, Mo Xian , Guang Zhao

Journal: Nat Commun .

PubMed ID: 37648707

Doi: 10.1038/s41467-023-41135-7

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Novel "GaEl Antigenic Patches" Identified by a "Reverse Epitomics" Approach to Design Multipatch Vaccines against NIPAH Infection, a Silent Threat to Global Human Health

Authors: Sukrit Srivastava, Michael Kolbe

Journal: ACS Omega

PubMed ID: 37692250

Doi: 10.1021/acsomega.3c01909

Products & Services: Proteins, Expression, Isolation and Analysis

Peripheral substitution effects on unnatural base pairs: A case of brominated TPT3 to enhance replication fidelity

Authors: Bianbian Huo, Chao Wang, Xiaoqi Hu, Honglei Wang, Gongming Zhu, Anlian Zhu, Lingjun Li

Journal: Bioorg Chem

PubMed ID: 37683537

Doi: 10.1016/j.bioorg.2023.106827

Products & Services: Proteins, Expression, Isolation and Analysis

Context-dependent role of Pho binding sites in Polycomb complex recruitment in Drosophila

Authors: Janet Lesley Brown, Joshua D Price, Maksim Erokhin, Judith A Kassis

Journal: Genetics

PubMed ID: 37216193

Doi: 10.1093/genetics/iyad096

Products & Services: Proteins, Expression, Isolation and Analysis

Time-resolved cryo-EM using a combination of droplet microfluidics with on-demand jetting

Authors: Stefania Torino, Mugdha Dhurandhar, Annelore Stroobants, Raf Claessens, Rouslan G Efremov

Journal: Nat Methods

PubMed ID: 37592181

Doi: 10.1038/s41592-023-01967-z

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Enhancement of Neutralization Responses through Sequential Immunization of Stable Env Trimers Based on Consensus Sequences from Select Time Points by Mimicking Natural Infection

Authors: Mingming Wan, Xiao Yang, Jie Sun, Elena E Giorgi, Xue Ding, Yan Zhou, Yong Zhang, Weiheng Su, Chunlai Jiang, Yaming Shan, Feng Gao

Journal: Int J Mol Sci

PubMed ID: 37628824

Doi: 10.3390/ijms241612642

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Rice-produced classical swine fever virus glycoprotein E2 with herringbone-dimer design to enhance immune responses

Authors: Qianru Xu, Fanshu Ma, Daichang Yang, Qingmei Li, Liming Yan, Jiquan Ou, Longxian Zhang, Yunchao Liu, Quan Zhan, Rui Li, Qiang Wei, Hui Hu, Yanan Wang, Xueyang Li, Shenli Zhang, Jifei Yang, Shujun Chai, Yongkun Du, Li Wang, Erqin Zhang, Gaiping Zhang

Journal: Plant Biotechnol J

PubMed ID: 37572354

Doi: 10.1111/pbi.14152

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Nanoparticles carrying paclitaxel and anti-miR-221 for breast cancer therapy triggered by ultrasound

Authors: Libo Zhang, Zhen Ren, Jinhui Lü, Xinhai Mo, Jie Lin, Ya Li, Wenjing Ma, Pengfei Liu, Yajing Shen, Qian Zhao, Lu Qian, Xiaoxin Cheng, Zuoren Yu, Bo Zhang

Journal: Cell Death Discov

PubMed ID: 37582832

Doi: 10.1038/s41420-023-01594-9

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Precision Genome Engineering in Based on a Broad-Host-Range Vector and CRISPR-Cas9 Technology

Authors: Alex Gussak, Maria Laura Ferrando, Mels Schrama, Peter van Baarlen, Jerry Mark Wells

Journal: ACS Synth Biol

PubMed ID: 37602730

Doi: 10.1021/acssynbio.3c00110

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Structure and design of Langya virus glycoprotein antigens

Authors: Zhaoqian Wang, Matthew McCallum, Lianying Yan, William Sharkey, Young-Jun Park, Ha V Dang, Moushimi Amaya, Ashley Person, Christopher C Broder, David Veesler

Journal: biorxiv

PubMed ID: 37645760

Doi: 10.1101/2023.08.20.554025

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Structural mechanism of synergistic targeting of the nucleosome by PU1 and C/EBPα

Authors: Tengfei Lian, Ruifang Guan, Bing-Rui Zhou, Yawen Bai

Journal: biorxiv

PubMed ID: 37790476

Doi: 10.1101/2023.08.25.554718

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Stromal cell-derived factor-1 downregulation contributes to neuroprotection mediated by CXC chemokine receptor 4 interactions after intracerebral hemorrhage in rats

Authors: Yu Wu, Zhuwei Zhang, Xiaoou Sun, Jing Wang, Haitao Shen, Xue Sun, Zhong Wang

Journal: CNS Neurosci Ther

PubMed ID: 37614198

Doi: 10.1111/cns.14400

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Origin of the OAS–RNase L innate immune pathway before the rise of jawed vertebrates via molecular tinkering

Authors: Lingyu Chu , Zhen Gong , Wenqiang Wang , Guan-Zhu Han

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 37487089

Doi: 10.1073/pnas.2304687120

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Backbone-Installed Split Intein-Assisted Ligation for the Chemical Synthesis of Mirror-Image Proteins

Authors: Baochang Zhang, Yupeng Zheng, Guochao Chu, Xiangyu Deng, Tongyue Wang, Weiwei Shi, Yongkang Zhou, Shan Tang , Ji-Shen Zheng ， Lei Liu

Journal: Angew Chem Int Ed Engl

PubMed ID: 37357888

Doi: 10.1002/anie.202306270

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Enhancement of β-carotene content in Chlamydomonas reinhardtii by expressing bacterium-driven lycopene β-cyclase

Authors: Danqiong Huang , Chenglong Liu , Mingshan Su , Zhiyong Zeng , Chaogang Wang , Zhangli Hu , Sulin Lou , Hui Li

Journal: Biotechnol Biofuels Bioprod .

PubMed ID: 37573357

Doi: 10.1186/s13068-023-02377-1

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Crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing

Authors: Lenong Li, Xubiao Peng, Mansoor Batliwala, Marlene Bouvier

Journal: Nat Commun

PubMed ID: 37596268

Doi: 10.1038/s41467-023-40736-6

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Early proteostasis of caveolins synchronizes trafficking, degradation, and oligomerization to prevent toxic aggregation

Authors: Frederic Morales-Paytuví, Alba Fajardo, Carles Ruiz-Mirapeix, James Rae, Francesc Tebar, Marta Bosch, Carlos Enrich, Brett M Collins, Robert G Parton, Albert Pol

Journal: J Cell Biol

PubMed ID: 37526691

Doi: 10.1083/jcb.202204020

Products & Services: Proteins, Expression, Isolation and Analysis

Anti-SARS-CoV-2 Antibody Level Is Associated with a History of COVID-19 Infection and mRNA Vaccination in Patients with Diabetes

Authors: Is Asma'ul Haq Hataul, Nanny Natalia M Soetedjo, Josephine Debora, Marita Restie Tiara, Hofiya Djauhari, Evan Susandi, Bachti Alisjahbana, Rudi Wisaksana, Hikmat Permana

Journal: Vaccines (Basel)

PubMed ID: 37766101

Doi: 10.3390/vaccines11091424

Products & Services: Proteins, Expression, Isolation and Analysis

Interchangeability of the Assays Used to Assess the Activity of Anti-SARS-CoV-2 Monoclonal Antibodies

Authors: Brady T Hickerson, Alexey M Khalenkov, Tao Xie, David M Frucht, Dorothy E Scott, Natalia A Ilyushina

Journal: Viruses

PubMed ID: 37632039

Doi: 10.3390/v15081698

Products & Services: Proteins, Expression, Isolation and Analysis

Variation in microbial feature perception in the Rutaceae family with immune receptor conservation in citrus

Authors: Jessica Trinh, Tianrun Li, Jessica Y Franco, Tania Y Toruño, Danielle M Stevens, Shree P Thapa, Justin Wong, Rebeca Pineda, Emmanuel Ávila de Dios, Tracy L Kahn, Danelle K Seymour, Chandrika Ramadugu, Gitta L Coaker

Journal: Plant Physiol

PubMed ID: 37144828

Doi: 10.1093/plphys/kiad263

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NLRC4 promotes the cGAS-STING signaling pathway by facilitating CBL-mediated K63-linked polyubiquitination of TBK1

Authors: Rongzhao Zhang, Wenxian Yang, Huifang Zhu, Jingbo Zhai, Mengzhou Xue, Chunfu Zheng

Journal: J Med Virol

PubMed ID: 37537877

Doi: 10.1002/jmv.29013

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Gene co-option, duplication and divergence of cement proteins underpin the evolution of bioadhesives across barnacle life histories

Authors: Yue Him Wong, Niklas Dreyer, HaoCheng Liu, Yi Lan, Jamie J Chen, Jin Sun, Wei-Peng Zhang, Pei-Yuan Qian, Benny K K Chan

Journal: Mol Ecol

PubMed ID: 37584177

Doi: 10.1111/mec.17084

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Stabilisation of the RirA [4Fe-4S] cluster results in loss of iron-sensing function

Authors: Elizabeth Gray, Melissa Y Y Stewart, Libby Hanwell, Jason C Crack, Rebecca Devine, Clare E M Stevenson, Anne Volbeda, Andrew W B Johnston, Juan C Fontecilla-Camps, Matthew I Hutchings, Jonathan D Todd, Nick E Le Brun

Journal: Chem Sci

PubMed ID: 37736639

Doi: 10.1039/d3sc03020b

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Neutrophil-Mediated Tumor-Targeting Delivery System of Oncolytic Bacteria Combined with ICB for Melanoma Lung Metastasis Therapy

Authors: Lina Liu, Wenjie Xin, Qiang Li, Baolian Huang, Te Yin, Siqi Hua, Chen Yang, Chen Chen, Chao Han, Zichun Hua

Journal: Adv Sci (Weinh)

PubMed ID: 37565362

Doi: 10.1002/advs.202301835

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Soluble SARS-CoV-2 RBD and human ACE2 peptidase domain produced in Drosophila S2 cells show functions evoking virus-cell interface

Authors: Federico Carrión, Florencia Rammauro, Natalia Olivero-Deibe, Martín Fló, María Magdalena Portela, Analía Lima, Rosario Durán, Otto Pritsch, Sergio Bianchi

Journal: Protein Sci

PubMed ID: 37405395

Doi: 10.1002/pro.4721

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Garlic-derived exosome-like nanovesicles as a hepatoprotective agent alleviating acute liver failure by inhibiting CCR2/CCR5 signaling and inflammation

Authors: Xin Zhao, Fang Yin, Luoqin Fu, Yingyu Ma, Luyi Ye, Yilin Huang, Weijiao Fan, Wenxue Gao, Yu Cai, Xiaozhou Mou

Journal: Biomater Adv

PubMed ID: 37717364

Doi: 10.1016/j.bioadv.2023.213592

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Rapid and ultrasensitive detection of mpox virus using CRISPR/Cas12b-empowered graphene field-effect transistors

Authors: LiWang;ChangXu;ShaohuiZhang ;ShangChen;HaoWang;ZhaojunDuan;OmarA.Al-Hartomy ;SwelmWageh;XiaoshaWen;YiLiu;YiLin;HuijiePu;ZhongjianXie;QuanLiu;HanZhang;DixianLuo

Journal: Applied Physics Reviews

Doi: 10.1063/5.0142494

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Rapid and automated design of two-component protein nanomaterials using ProteinMPNN

Authors: Robbert J de Haas, Natalie Brunette, Alex Goodson, Justas Dauparas, Sue Y Yi, Erin C Yang, Quinton Dowling, Hannah Nguyen, Alex Kang, Asim K Bera, Banumathi Sankaran, Renko de Vries, David Baker, Neil P King

Journal: biorxiv

PubMed ID: 37577478

Doi: 10.1101/2023.08.04.551935

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Flow-cytometric cell sorting coupled with UV mutagenesis for improving pectin lyase expression

Authors: Ke Fang , Jun Ma , Xinyu Wang, Ziting Xu , Ziyang Zhang , Piwu Li , Ruiming Wang, Junqing Wang, Chuying Sun and Ziyang Dong

Journal: Frontiers in bioengineering and biotechnology

Doi: 10.3389/fbioe.2023.1251342

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Multimodal, broadly neutralizing antibodies against SARS-CoV-2 identified by high-throughput native pairing of BCRs from bulk B cells

Authors: Gladys J Keitany , Benjamin E R Rubin , Meghan E Garrett , Andrea Musa , Jeff Tracy , Yu Liang , Peter Ebert , Amanda J Moore , Jonathan Guan , Erica Eggers , Ninnia Lescano , Ryan Brown , Adria Carbo , Hussein Al-Asadi , Travers Ching , Austin Day , Rebecca Harris , Charles Linkem , Dimitry Popov , Courtney Wilkins , Lianqu Li , Jiao Wang , Chuanxin Liu , Li Chen , Jennifer N Dines , Caroline Atyeo , Galit Alter , Lance Baldo , Anna Sherwood , Bryan Howie , Mark Klinger , Erik Yusko , Harlan S Robins , Sharon Benzeno , Amy E Gilbert

Journal: Cell Chem Biol .

PubMed ID: 37586370

Doi: 10.1016/j.chembiol.2023.07.011

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A near-infrared fluorescence-enhancing plasmonic biosensing microarray identifies soluble PD-L1 and ICAM-1 as predictive checkpoint biomarkers for cancer immunotherapy

Authors: Zhijun Lin, Mengyao Liu, Wei Xing, Fenghua Wang, Hongxia Zhang, Xiaoli Wei, Hans Schmitthenner, Xi Xie, Xiaojun Xia, Jiang Yang

Journal: Biosens Bioelectron

PubMed ID: 37683502

Doi: 10.1016/j.bios.2023.115633

Products & Services: Proteins, Expression, Isolation and Analysis

The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA1, BA2, and BA5

Authors: Huiping Shuai, Jasper Fuk-Woo Chan, Bingjie Hu, Yue Chai, Chaemin Yoon, Huan Liu, Yuanchen Liu, Jialu Shi, Tianrenzheng Zhu, Jing-Chu Hu, Ye-Fan Hu, Yuxin Hou, Xiner Huang, Terrence Tsz-Tai Yuen, Yang Wang, Jinjin Zhang, Yao Xia, Lin-Lei Chen, Jian-Piao Cai, Anna Jinxia Zhang, Shuofeng Yuan, Jie Zhou, Bao-Zhong Zhang, Jian-Dong Huang, Kwok-Yung Yuen, Kelvin Kai-Wang To, Hin Chu

Journal: EBioMedicine

PubMed ID: 37579626

Doi: 10.1016/j.ebiom.2023.104753

Products & Services: Proteins, Expression, Isolation and Analysis

ABBV-184: A Novel Survivin-specific TCR/CD3 Bispecific T-cell Engager is Active against Both Solid Tumor and Hematologic Malignancies

Authors: Adam S Chervin, Jennifer D Stone, Iwona Konieczna, Kelly M Calabrese, Ningyan Wang, Dipica Haribhai, Feng Dong, Michael K White, Luis E Rodriguez, Gail T Bukofzer, Paul A Ellis, Cormac Cosgrove, Claudie Hecquet, Jerry D Clarin, Joann P Palma, Edward B Reilly

Journal: Mol Cancer Ther

PubMed ID: 37294945

Doi: 10.1158/1535-7163.MCT-22-0770

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Expression analysis, clinical significance and potential function of PLXNB2 in acute myeloid leukaemia

Authors: Zhibo Guo, Dan Guo, Desheng Kong, Sicheng Bian, Linlin Zhao, Qi Li, Leilei Lin, Jiali Hao, Lili Sun, Yinghua Li

Journal: Mol Biol Rep

PubMed ID: 37632633

Doi: 10.1007/s11033-023-08721-w

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Biosynthesis of High-Active Hemoproteins by the Efficient Heme-Supply Pichia Pastoris Chassis

Authors: Fei Yu, Xinrui Zhao, Jingwen Zhou, Wei Lu, Jianghua Li, Jian Chen, Guocheng Du

Journal: Adv Sci (Weinh)

PubMed ID: 37649147

Doi: 10.1002/advs.202302826

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CircRNA-CIRH1A Promotes the Development of Osteosarcoma by Regulating PI3K/AKT and JAK2/STAT3 Signaling Pathways

Authors: Meng Zhang, Xiang Wang, Jianfeng Zhao, Jizhou Yan, Xiaodan He, Danxia Qin, Fang Liang, Kai Tong, Jianjian Wang

Journal: Mol Biotechnol

PubMed ID: 37608076

Doi: 10.1007/s12033-023-00812-0

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Id-neoantigen vaccine induces therapeutic CD8 T cells against multiple myeloma: H chain-loss escapees cause FLC MM

Authors: Marita Westhrin, Jana Blazevski, Ana Textor, Pegah Abdollahi, Ramakrishna Prabhu Gopalakrishnan, Linda Thuy Ngo, Peter Olaf Hofgaard, Julia Heinzelbecker, Sonja Bobic, Even Fossum, Heidi Cecilie Larsen Spång, Ranveig Braathen, Bjarne Bogen

Journal: J Immunother Cancer

PubMed ID: 37607769

Doi: 10.1136/jitc-2023-006944

Products & Services: Proteins, Expression, Isolation and Analysis

Obtaining high yield recombinant Enterococcus faecium nicotinate nucleotide adenylyltransferase for X-ray crystallography and biophysical studies

Authors: Olamide Jeje, Ramesh Pandian, Yasien Sayed, Ikechukwu Achilonu

Journal: Int J Biol Macromol

PubMed ID: 37544558

Doi: 10.1016/j.ijbiomac.2023.126066

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NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis

Authors: Quentin I B Lemaître, Natascha Bartsch, Ian U Kouzel, Henriette Busengdal, Gemma Sian Richards, Patrick R H Steinmetz, Fabian Rentzsch

Journal: Nat Commun

PubMed ID: 37563174

Doi: 10.1038/s41467-023-39789-4

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Role of the CagY antenna projection in Cag type IV secretion system activity

Authors: Sirena C Tran, Mark S McClain, Timothy L Cover

Journal: Infect Immun

PubMed ID: 37638724

Doi: 10.1128/iai.00150-23

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