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Retinoid X receptor gamma dictates the activation threshold of group 2 innate lymphoid cells and limits type 2 inflammation in the small intestine

Authors: Yang Zang , Shaorui Liu , Zebing Rao , Yinsheng Wang , Boya Zhang , Hui Li , Yingjiao Cao , Jie Zhou , Zhuxia Shen , Shengzhong Duan , Danyang He , Heping Xu

Journal: Immunity .

PubMed ID: 37714152

Doi: 10.1016/j.immuni.2023.08.019

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Elevating plant immunity by translational regulation of a rice WRKY transcription factor

Authors: Chao Zheng , Jie Zhou , Xiaoya Yuan , Ersong Zheng , Xiuli Liu , Weijun Cui , Chengqi Yan , Yueyan Wu , Wenyuan Ruan , Keke Yi , Jianping Chen , Xuming Wang

Journal: Plant Biotechnol J .

PubMed ID: 37997501

Doi: 10.1111/pbi.14243

Products & Services: Proteins, Expression, Isolation and Analysis

O-Linked N-Acetylglucosamine Transferase Regulates Bone Homeostasis Through Alkaline Phosphatase Pathway in Diabetic Periodontitis

Authors: Wei Luo, Lu Sun

Journal: Mol Biotechnol

PubMed ID: 37951846

Doi: 10.1007/s12033-023-00947-0

Products & Services: Proteins, Expression, Isolation and Analysis

Transcriptomic analyses reveal proinflammatory activation of human brain microvascular endothelial cells by aging-associated peptide medin and reversal by nanoliposomes

Authors: Yining Zhang, Nina Karamanova, Kaleb T Morrow, Jillian Madine, Seth Truran, Maria Lozoya, Volkmar Weissig, Ming Li, Mehdi Nikkhah, Jin G Park, Raymond Q Migrino

Journal: Sci Rep

PubMed ID: 37914766

Doi: 10.1038/s41598-023-45959-7

Products & Services: Proteins, Expression, Isolation and Analysis

Development of a Multispecies Double-Antigen Sandwich ELISA Using N and RBD Proteins to Detect Antibodies against SARS-CoV-2

Authors: Maritza Cordero-Ortiz, Mónica Reséndiz-Sandoval, Freddy Dehesa-Canseco, Mario Solís-Hernández, Jahir Pérez-Sánchez, Carlos Martínez-Borges, Verónica Mata-Haro, Jesús Hernández

Journal: Animals (Basel)

PubMed ID: 38003105

Doi: 10.3390/ani13223487

Products & Services: Molecular Biology Reagents

Identification of CryAB as a target of NUAK kinase activity in Drosophila muscle tissue

Authors: Ziwei Zhao, David Brooks, Yungui Guo, Erika R Geisbrecht

Journal: Genetics

PubMed ID: 37713608

Doi: 10.1093/genetics/iyad167

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Arabidopsis calmodulin-like proteins CML13 and CML14 interact with calmodulin-binding transcriptional activators and function in salinity stress response

Authors: Bryan Hau, Kyle Symonds, Howard Teresinski, Abby Janssen, Liam Duff, Milena Smith, Kirsten Benidickson, William Plaxton, Wayne A Snedden

Journal: Plant Cell Physiol

PubMed ID: 38036467

Doi: 10.1093/pcp/pcad152

Development of a C3 humanized rat as a new model for evaluating novel C3 inhibitors

Authors: Jin Chen, Lingjun Zhang, Maojing Yang, Elizabeth D Hughes, Zach Freeman, Thomas L Saunders, Feng Lin

Journal: J Innate Immun

PubMed ID: 38035563

Doi: 10.1159/000534963

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Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

Authors: Shudan Tan, Jinghua Zhao, Xue Hu, Yufeng Li, Zihan Wu, Guoliang Lu, Zhaoli Yu, Binhe Du, Yan Liu, Li Li, Yuchen Chen, Ye Li, Yanfeng Yao, Xiaoyu Zhang, Juhong Rao, Ge Gao, Yun Peng, Hang Liu, Zhiming Yuan, Jia Liu, Qianran Wang, Hengrui Hu, Xiaobo Gao, Hui Zhou, Hang Yu, Yingjie Xu, Wei Yu, Lin Feng, Manli Wang, Chao Shan, Jing Lu, Jinzhong Lin

Journal: Sci Bull (Beijing)

PubMed ID: 37993332

Doi: 10.1016/j.scib.2023.11.024

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Enhancement of adeno-associated virus serotype 6 transduction into T cells with cell-penetrating peptides

Authors: Pablo D Moço, Shantoshini Dash, Amine A Kamen

Journal: J Gene Med

PubMed ID: 37957034

Doi: 10.1002/jgm.3627

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Self−Assembling Nanovaccine Fused with Flagellin Enhances Protective Effect against Foot−and−Mouth Disease Virus

Authors: Chenchen Pei , Hu Dong , Zhidong Teng , Sumin Wei , Yun Zhang , Shuanghui Yin , Jianli Tang , Shiqi Sun and Huichen Guo

Journal: Vaccines

Doi: 10.3390/vaccines11111675

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Multiple highly expressed phosphoenolpyruvate carboxylase genes have divergent enzyme kinetic properties in two C4 grasses

Authors: Robert J DiMario, Ashley N Kophs, Anthony J A Apalla, James N Schnable, Asaph B Cousins

Journal: Ann Bot

PubMed ID: 37675505

Doi: 10.1093/aob/mcad116

Products & Services: Proteins, Expression, Isolation and Analysis

The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson's disease

Authors: Lanxia Meng, Congcong Liu, Yiming Li, Guiqin Chen, Min Xiong, Ting Yu, Lina Pan, Xingyu Zhang, Lingyan Zhou, Tao Guo, Xin Yuan, Chaoyang Liu, Zhaohui Zhang, Zhentao Zhang

Journal: Sci Adv

PubMed ID: 37910610

Doi: 10.1126/sciadv.adj1092

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Depletion of L-Methionine in Foods with an Engineered Thermophilic Methionine γ-lyase Efficiently Inhibits Tumor Growth

Authors: Yangming Hu, Yan Liu, Jiulin Zhang, Zhijing Zhou, Jiaxue Wang, Hongyang Chen, Meina Huang, Han Hu, Zongjie Dai, Kaizhi Jia

Journal: J Agric Food Chem

PubMed ID: 37909421

Doi: 10.1021/acs.jafc.3c05293

Products & Services: Proteins, Expression, Isolation and Analysis

A novel stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids

Authors: Jennifer M Podgorski, Joshua Podgorski, Lawrence Abad, Deborah Jacobs-Sera, Krista G Freeman, Colin Brown, Graham Hatfull, Antoni Luque, Simon J White

Journal: biorxiv

PubMed ID: 37961133

Doi: 10.1101/2023.11.03.565530

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Evaluating the stability of host-reference gene expression and simultaneously quantifying parasite burden and host immune responses in murine malaria

Authors: Daniel J Browne, Ashton M Kelly, Jamie Brady, Carla Proietti, Yomani D Sarathkumara, David J Pattinson, Denise L Doolan

Journal: Sci Rep

PubMed ID: 38030676

Doi: 10.1038/s41598-023-48066-9

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Enhanced C-To-T and A-To-G Base Editing in Mitochondrial DNA with Engineered DdCBE and TALED

Authors: Yinghui Wei, Ming Jin, Shuhong Huang, Fangyao Yao, Ningxin Ren, Kun Xu, Shangpu Li, Pengfei Gao, Yingsi Zhou, Yulin Chen, Hui Yang, Wen Li, Chunlong Xu, Meiling Zhang, Xiaolong Wang

Journal: Adv Sci (Weinh)

PubMed ID: 37984866

Doi: 10.1002/advs.202304113

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FGFR1 expression correlates inversely with the efficacy of single-agent FGFR-specific inhibitors in pancreatic cancer

Authors: Qingxiang Lin, Andrea Serratore, Jonathan Perri, Tista Roy Chaudhuri, Jun Qu, Wen Wee Ma, Eugene Kandel, Robert M Straubinger

Journal: Br J Pharmacol

PubMed ID: 37994108

Doi: 10.1111/bph.16289

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Carvedilol impairs bile acid homeostasis in mice: implication for nonalcoholic steatohepatitis

Authors: Hana Lastuvkova, Zuzana Nova, Milos Hroch, Fatemeh Alaei Faradonbeh, Jolana Schreiberova, Jaroslav Mokry, Hana Faistova, Alzbeta Stefela, Jan Dusek, Otto Kucera, Radomír Hyspler, Ester Dohnalkova, Rachel L Bayer, Petra Hirsova, Petr Pavek, Stanislav Micuda

Journal: Toxicol Sci

PubMed ID: 37632784

Doi: 10.1093/toxsci/kfad088

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Enzymatic degradation of poly(ethylene terephthalate) (PET): Identifying the cause of the hypersensitive enzyme kinetic response to increased PET crystallinity

Authors: Thore Bach Thomsen, Tobias S Radmer, Anne S Meyer

Journal: Enzyme Microb Technol

PubMed ID: 37979402

Doi: 10.1016/j.enzmictec.2023.110353

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Forming a chromium-based interstrand DNA crosslink: Implications for carcinogenicity

Authors: Silas Brown , Sydney Marchi , C Sumner Thomas , Ashlyn R Hale , Molly Lockart , Michael K Bowman , George Christou , Stephen A Woski , John B Vincent

Journal: J Inorg Biochem .

PubMed ID: 38039560

Doi: 10.1016/j.jinorgbio.2023.112439

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Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity

Authors: Le Zheng, Tingting Yang , Hangtian Guo , Chen Qi , Yuchi Lu , Haonan Xiao , Yan Gao , Yue Liu, Yixuan Yang , Mengru Zhou , Henry C Nguyen 1, Yun Zhu 8, Fei Sun 9 10, Chen-Yu Zhang , Xiaoyun Ji

Journal: Cell Research

PubMed ID: 37932445

Doi: s41422-023-00893-1

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Characterization of an L-Arabinose Isomerase from Bacillus velezensis and Its Application for L-Ribulose and L-Ribose Biosynthesis

Authors: Zongren Guo, Liangkun Long, Shaojun Ding

Journal: Appl Biochem Biotechnol

PubMed ID: 32617845

Doi: 10.1007/s12010-020-03380-0

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A Novel mechanism of herbicide action through disruption of pyrimidine biosynthesis

Authors: Il-Ho Kang, Ryan P Emptage, Sang-Ic Kim, Steven Gutteridge

Journal: Proc Natl Acad Sci U S A

PubMed ID: 37988466

Doi: 10.1073/pnas.2313197120

Products & Services: Proteins, Expression, Isolation and Analysis

SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer

Authors: Xiayao Diao, Chao Guo, Hanhao Zheng, Ke Zhao, Yuming Luo, Mingjie An, Yan Lin, Jiancheng Chen, Yuanlong Li, Yuting Li, Xuehan Gao, Jiaqi Zhang, Mengxin Zhou, Wenliang Bai, Lei Liu, Guige Wang, Lanjun Zhang, Xiaotian He, Rusi Zhang, Zhihua Li, Changhao Chen, Shanqing Li

Journal: Signal Transduct Target Ther

PubMed ID: 37925421

Doi: 10.1038/s41392-023-01685-0

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Bovine papular stomatitis virus as a vaccine vector for cattle

Authors: Gustavo Delhon, Sushil Khatiwada, David Doub, Seth Harris, Sabal Chaulagain, Mostafa El-Gaffary, Daniel L Rock

Journal: J Gen Virol

PubMed ID: 37976092

Doi: 10.1099/jgv.0.001914

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Functional and Extracellular Production and Antitumor Activity of Mouse Alpha Klotho in Model Microalga Chlamydomonas reinhardtii

Authors: Ramazan Çakmak, Ugur Uzuner

Journal: Chem Biodivers

PubMed ID: 37997005

Doi: 10.1002/cbdv.202301255

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The sleep quality- and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the enzyme

Authors: Irina Sbornova, Emilie van der Sande, Snezana Milosavljevic, Elvis Amurrio, Steven D Burbano, Prosun Das, Helen Do, Janet L Fisher, Porschderek Kargbo, Janvi Patel, Latarsha Porcher, Chris I De Zeeuw, Magda A Meester-Smoor, Beerend H J Winkelman, Caroline C W Klaver, Ana Pocivavsek, Michy P Kelly

Journal: biorxiv

PubMed ID: 38014312

Doi: 10.1101/2023.11.16.567422

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Identification of NAD-RNA species and ADPR-RNA decapping in Archaea

Authors: José Vicente Gomes-Filho, Ruth Breuer, Hector Gabriel Morales-Filloy, Nadiia Pozhydaieva, Andreas Borst, Nicole Paczia, Jörg Soppa, Katharina Höfer, Andres Jäschke, Lennart Randau

Journal: Nat Commun

PubMed ID: 37989750

Doi: 10.1038/s41467-023-43377-x

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Enzymatic β-elimination in natural product O- and C-glycoside deglycosylation

Authors: Johannes Bitter, Martin Pfeiffer, Annika J E Borg, Kirill Kuhlmann, Tea Pavkov-Keller, Pedro A Sánchez-Murcia, Bernd Nidetzky

Journal: Nat Commun

PubMed ID: 37932298

Doi: 10.1038/s41467-023-42750-0

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M mazei glutamine synthetase and glutamine synthetase-GlnK1 structures reveal enzyme regulation by oligomer modulation

Authors: Maria A Schumacher, Raul Salinas, Brady A Travis, Rajiv Ranjan Singh, Nicholas Lent

Journal: Nat Commun

PubMed ID: 37968329

Doi: 10.1038/s41467-023-43243-w

Products & Services: Proteins, Expression, Isolation and Analysis

Retraction Note: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

Authors: Mark Yarmarkovich, Quinlen F Marshall, John M Warrington, Rasika Premaratne, Alvin Farrel, David Groff, Wei Li, Moreno di Marco, Erin Runbeck, Hau Truong, Jugmohit S Toor, Sarvind Tripathi, Son Nguyen, Helena Shen, Tiffany Noel, Nicole L Church, Amber Weiner, Nathan Kendsersky, Dan Martinez, Rebecca Weisberg, Molly Christie, Laurence Eisenlohr, Kristopher R Bosse, Dimiter S Dimitrov, Stefan Stevanovic, Nikolaos G Sgourakis, Ben R Kiefel, John M Maris

Journal: Nature

PubMed ID: 37938785

Doi: 10.1038/s41586-023-06731-z

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Using for high-yield production of challenging expression targets and for protein deuteration

Authors: Natalia Mojica, Flore Kersten, Mateu Montserrat-Canals, G Robb Huhn, Abelone M Tislevoll, Gabriele Cordara, Ken Teter, Ute Krengel

Journal: biorxiv

PubMed ID: 37961550

Doi: 10.1101/2023.11.03.565449

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Fungi of the order Mucorales express a "sealing-only" tRNA ligase

Authors: Khondakar Sayef Ahammed, Ambro van Hoof

Journal: biorxiv

PubMed ID: 38014270

Doi: 10.1101/2023.11.16.567474

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Specifications of qPCR based epigenetic immune cell quantification

Authors: Konstantin Schildknecht, Björn Samans, Jasmin Gussmann, Udo Baron, Eva Raschke, Nina Babel, Julia Oppatt, Katharina Gellhaus, Araceli Rossello, Isabell Janack, Sven Olek

Journal: Clin Chem Lab Med

PubMed ID: 37982750

Doi: 10.1515/cclm-2023-1056

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Peptide Amphiphiles as Biodegradable Adjuvants for Efficient Retroviral Gene Delivery

Authors: Kübra Kaygisiz, Lena Rauch-Wirth, Aysenur Iscen, Jan Hartenfels, Kurt Kremer, Jan Münch, Christopher V Synatschke, Tanja Weil

Journal: Adv Healthc Mater

PubMed ID: 37947246

Doi: 10.1002/adhm.202301364

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Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy

Authors: Ali Ghasemi, Amaia Martinez-Usatorre, Luqing Li, Mehdi Hicham, Alan Guichard, Rachel Marcone, Nadine Fournier, Bruno Torchia, Darel Martinez Bedoya, Suzel Davanture, Mirian Fernández-Vaquero, Chaofan Fan, Jakob Janzen, Yahya Mohammadzadeh, Raphael Genolet, Nahal Mansouri, Mathias Wenes, Denis Migliorini, Mathias Heikenwalder, Michele De Palma

Journal: Nat Cancer

PubMed ID: 37996514

Doi: 10.1038/s43018-023-00668-y

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Oxidative stress and signaling through EGFR and PKA pathways converge on the nuclear transport factor RanBP1

Authors: Mohamed Kodiha, Nabila Azad, Siwei Chu, Noah Crampton, Ursula Stochaj

Journal: Eur J Cell Biol

PubMed ID: 38011756

Doi: 10.1016/j.ejcb.2023.151376

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Abundant binary promoter switches in lineage-determining transcription factors indicate a digital component of cell fate determination

Authors: Hongchuan Li, Md Ahasanur Rahman, Michael Ruesch, Caprice D Eisele, Erik M Anderson, Paul W Wright, Jennie Cao, Shashikala Ratnayake, Qingrong Chen, Chunhua Yan, Daoud Meerzaman, Roshini S Abraham, Aharon G Freud, Stephen K Anderson

Journal: Cell Rep

PubMed ID: 37976160

Doi: 10.1016/j.celrep.2023.113454

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Circulating extracellular choline acetyltransferase regulates inflammation

Authors: Arielle H Gabalski, Aisling Tynan, Tea Tsaava, Jian Hua Li, Diana Lee, Tyler D Hepler, Daniel Hide, Sam George, Carlos E Bravo Iñiguez, Dane A Thompson, Cassie Zhu, Haichao Wang, Michael Brines, Kevin J Tracey, Sangeeta S Chavan

Journal: J Intern Med

PubMed ID: 38011942

Doi: 10.1111/joim.13750

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Nanopore Signatures of Nucleoside Drugs

Authors: Wendong Jia , Yusheng Ouyang , Shanyu Zhang , Xiaoyu Du , Panke Zhang , Shuo Huang

Journal: Nano Lett .

PubMed ID: 37818841

Doi: 10.1021/acs.nanolett.3c02872

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A chlorophyll c synthase widely co-opted by phytoplankton

Authors: Yanyou Jiang , Tianjun Cao , Yuqing Yang , Huan Zhang , Jingyu Zhang , Xiaobo Li

Journal: Science .

PubMed ID: 37797009

Doi: 10.1126/science.adg7921

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HDL mimetics protect Alzheimer’s patients carrying APOE ε4 from SARS-CoV-2 invasion

Authors: Ruodan Xu , Junwei Gao , Can Cao , Mingfei Shi , Yonghui Zhang , Shihao Hong , Shijie Guo , Menglin Chen , Ping Song , Gaoshuang Fu , Jing Li , Tengxiao Liang , Yingchun Miao , Lu Tang , Jinsheng Yang , Ning Li , Mingdong Dong

Journal: Nano Today

Doi: 10.1016/j.nantod.2023.102051

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Development and characterization of anti-IL-5 monoclonal antibody Fab fragment for blocking IL-5/IL-5Rα binding

Authors: Shijie Li , Shijie Wang , Eric Fordjour , Yaoji Liang , Xuelian Wang , Yonghao Ye , Zhonghu Bai , Yankun Yang , Yongqi Chen

Journal: International Immunopharmacology

Doi: 10.1016/j.intimp.2023.111032

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Architecture and rearrangements of a sperm-specific Na/H exchanger

Authors: Sandipan Chowdhury, Kamalendu Pal

Journal: Res Sq

PubMed ID: 37886505

Doi: 10.21203/rs.3.rs-3396005/v1

Products & Services: Proteins, Expression, Isolation and Analysis

Extract2Chip-Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance

Authors: Ana C F Paiva, Ana R Lemos, Philipp Busse, Madalena T Martins, Diana O Silva, Micael C Freitas, Sandra P Santos, Filipe Freire, Evelyne J Barrey, Xavier Manival, Lisa Koetzner, Timo Heinrich, Ansgar Wegener, Ulrich Grädler, Tiago M Bandeiras, Daniel Schwarz, Pedro M F Sousa

Journal: Biosensors (Basel)

PubMed ID: 37887106

Doi: 10.3390/bios13100913

Products & Services: Proteins, Expression, Isolation and Analysis

Collagen Mimetic Peptide with a Coiled Coil Trimerization Domain Forms Fibrils Having -Period-like Structures

Authors: Faizunnahar Dewan, Michele Kirchner, Fadi Masoud, Zainab Sami, Yujia Xu

Journal: Biomacromolecules

PubMed ID: 37788665

Doi: 10.1021/acs.biomac.3c00901

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Pyruvate kinase is post-translationally regulated by sirtuin 2 in Aedes aegypti mosquitoes

Authors: Natthida Petchampai, Jun Isoe, Prashanth Balaraman, Max Oscherwitz, Brendan H Carter, Cecilia G Sánchez, Patricia Y Scaraffia

Journal: Insect Biochem Mol Biol

PubMed ID: 37797713

Doi: 10.1016/j.ibmb.2023.104015

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Influence of expression and purification protocols on Gα biochemical activity: kinetics of plant and mammalian G protein cycles

Authors: Timothy E Gookin, David Chakravorty, Sarah M Assmann

Journal: biorxiv

PubMed ID: 37214830

Doi: 10.1101/2023.05.10.540258

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Ceria Nanozyme Coordination with Curcumin for Treatment of Sepsis-induced Cardiac Injury by Inhibiting Ferroptosis and Inflammation

Authors: Chenxiao Jiang, Qianzhi Shi, Jing Yang, Hao Ren, Lu Zhang, Shan Chen, Jiayi Si, Yihai Liu, Dujuan Sha, Biao Xu, Jie Ni

Journal: J Adv Res

PubMed ID: 37871772

Doi: 10.1016/j.jare.2023.10.011

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Biochemical and structural characterization of a glucan synthase GFGLS2 from edible fungus Grifola frondosa to synthesize β-1, 3-glucan

Authors: Yu-Meng Yang, Xin Fu, Feng-Jie Cui, Lei Sun, Xin-Yi Zan, Wen-Jing Sun

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 37904199

Doi: 10.1186/s13068-023-02380-6

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A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity

Authors: Andras Boeszoermenyi, Léa Bernaleau, Xudong Chen, Felix Kartnig, Min Xie, Haobo Zhang, Sensen Zhang, Maeva Delacrétaz, Anna Koren, Ann-Katrin Hopp, Vojtech Dvorak, Stefan Kubicek, Daniel Aletaha, Maojun Yang, Manuele Rebsamen, Leonhard X Heinz, Giulio Superti-Furga

Journal: Nat Commun

PubMed ID: 37863876

Doi: 10.1038/s41467-023-42070-3

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Serpin-1a and serpin-6 regulate the Toll pathway immune homeostasis by synergistically inhibiting the Spätzle-processing enzyme CLIP2 in silkworm, Bombyx mori

Authors: Huawei Liu, Jiahui Xu, Luoling Wang, Pengchao Guo, Zhangchen Tang, Xiaotong Sun, Xin Tang, Wei Wang, Lingyan Wang, Yang Cao, Qingyou Xia, Ping Zhao

Journal: PLoS Pathog

PubMed ID: 37851691

Doi: 10.1371/journal.ppat.1011740

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KRAS G12V neoantigen specific T cell receptor for adoptive T cell therapy against tumors

Authors: Dan Lu, Yuan Chen, Min Jiang, Jie Wang, Yiting Li, Keke Ma, Wenqiao Sun, Xing Zheng, Jianxun Qi, Wenjing Jin, Yu Chen, Yan Chai, Catherine W H Zhang, Hao Liang, Shuguang Tan, George F Gao

Journal: Nat Commun

PubMed ID: 37828002

Doi: 10.1038/s41467-023-42010-1

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Distribution and Degradation of Pork Filamin during Postmortem Aging

Authors: Tongyao Du, Chao Ma, Zixu Wang, Yuejing Hao, Wangang Zhang

Journal: J Agric Food Chem

PubMed ID: 37788342

Doi: 10.1021/acs.jafc.3c04208

Products & Services: Proteins, Expression, Isolation and Analysis

Benzbromarone Induces Targeted Degradation of HSP47 Protein and Improves Hypertrophic Scar Formation

Authors: Jung Gyu Park, Dong Chul Lim, Jeong Hwan Park, Seoah Park, Jongsoo Mok, Keon Wook Kang, Joonghoon Park

Journal: J Invest Dermatol

PubMed ID: 37838329

Doi: 10.1016/j.jid.2023.09.279

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Molecular mechanism of sex pheromone perception in male Mythimna loreyi revealed by in vitro system

Authors: Yun-Ying Zhang, Teng-Fei Bai, Jin-Meng Guo, Zhi-Qiang Wei, Si-Ruo Liu, Yu He, Jing-Jing Ye, Qi Yan, Jin Zhang, Shuang-Lin Dong

Journal: Pest Manag Sci

PubMed ID: 37779104

Doi: 10.1002/ps.7806

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How myosin VI traps its off-state, is activated and dimerizes

Authors: Louise Canon , Carlos Kikuti , Vicente J Planelles-Herrero , Tianming Lin , Franck Mayeux , Helena Sirkia , Young Il Lee , Leila Heidsieck , Léonid Velikovsky , Amandine David , Xiaoyan Liu ， Dihia Moussaoui , Emma Forest , Peter Höök , Karl J Petersen , Tomos E Morgan , Aurélie Di Cicco , Julia Sirés-Campos , Emmanuel Derivery , Daniel Lévy , Cédric Delevoye , H Lee Sweeney , Anne Houdusse

Journal: Nat Commun

PubMed ID: 37872146

Doi: 10.1038/s41467-023-42376-2

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m6A methyltransferase METTL3 contributes to sympathetic hyperactivity post-MI via promoting TRAF6-dependent mitochondrial ROS production

Authors: Peijin Yang, Yu Wang, Weili Ge, Yanyan Jing, Hesheng Hu, Jie Yin, Mei Xue, Ye Wang, Xiaolu Li, Xinran Li, Yugen Shi, Jiayu Tan, Yan Li, Suhua Yan

Journal: Free Radic Biol Med

PubMed ID: 37898386

Doi: 10.1016/j.freeradbiomed.2023.10.392

Products & Services: Proteins, Expression, Isolation and Analysis

Single-cell chromatin state transitions during epigenetic memory formation

Authors: Taihei Fujimori, Carolina Rios-Martinez, Abby R Thurm, Michaela M Hinks, Benjamin R Doughty, Joydeb Sinha, Derek Le, Antonina Hafner, William J Greenleaf, Alistair N Boettiger, Lacramioara Bintu

Journal: biorxiv

PubMed ID: 37873344

Doi: 10.1101/2023.10.03.560616

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Entropy-driven reactions for controlling CRISPR/Cas12a and constructing an electrochemical biosensor for cardiac biomarkers detection

Authors: Jiaying Wang, Xianliang Wang, Bin Li, Kai Zhang, Jingyuan Mao

Journal: Mikrochim Acta

PubMed ID: 37845542

Doi: 10.1007/s00604-023-06012-6

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A retrospective study of SARS-CoV-2 seroprevalence in dogs and cats in the Community of Madrid, Spain

Authors: Lidia Sánchez-Morales, José M Sánchez-Vizcaíno, Lucas Domínguez, Sandra Barroso-Arévalo

Journal: Front Microbiol

PubMed ID: 37869682

Doi: 10.3389/fmicb.2023.1264172

Products & Services: Proteins, Expression, Isolation and Analysis

Functional dissection and assembly of a small, newly evolved, W chromosome-specific genomic region of the African clawed frog Xenopus laevis

Authors: Caroline M S Cauret, Danielle C Jordan, Lindsey M Kukoly, Sarah R Burton, Emmanuela U Anele, Jacek M Kwiecien, Marie-Theres Gansauge, Sinthu Senthillmohan, Eli Greenbaum, Matthias Meyer, Marko E Horb, Ben J Evans

Journal: PLoS Genet

PubMed ID: 37792893

Doi: 10.1371/journal.pgen.1010990

Products & Services: Proteins, Expression, Isolation and Analysis

A dry powder formulation for peripheral lung delivery and absorption of an anti-SARS-CoV-2 ACE2 decoy polypeptide

Authors: Stefania Glieca, Davide Cavazzini, Elisabetta Levati, Valentina Garrapa, Angelo Bolchi, Valentina Franceschi, Simone Odau, Simone Ottonello, Gaetano Donofrio, Jonas Füner, Fabio Sonvico, Ruggero Bettini, Barbara Montanini, Francesca Buttini

Journal: Eur J Pharm Sci

PubMed ID: 37838239

Doi: 10.1016/j.ejps.2023.106609

Products & Services: Proteins, Expression, Isolation and Analysis

Creating Designer Engineered Extracellular Vesicles for Diverse Ligand Display, Target Recognition, and Controlled Protein Loading and Delivery

Authors: Alena Ivanova, Lukas Badertscher, Gwen O'Driscoll, Joakim Bergman, Euan Gordon, Anders Gunnarsson, Camilla Johansson, Michael J Munson, Cristiana Spinelli, Sara Torstensson, Liisa Vilén, Andrei Voirel, John Wiseman, Janusz Rak, Niek Dekker, Elisa Lázaro-Ibáñez

Journal: Adv Sci (Weinh)

PubMed ID: 37867228

Doi: 10.1002/advs.202304389

Products & Services: Proteins, Expression, Isolation and Analysis

Hypoxia-responsive CAR-T cells exhibit reduced exhaustion and enhanced efficacy in solid tumors

Authors: Xiuxiu Zhu, Jun Chen, Wuling Li, Yanmin Xu, Juanjuan Shan, Juan Hong, Yongchun Zhao, Huailong Xu, Jiabing Ma, Junjie Shen, Cheng Qian

Journal: Cancer Res

PubMed ID: 37874330

Doi: 10.1158/0008-5472.CAN-23-1038

Products & Services: Proteins, Expression, Isolation and Analysis

X-ray crystallography study and optimization of novel benzothiophene analogs as potent selective estrogen receptor covalent antagonists (SERCAs) with improved potency and safety profiles

Authors: Chengfeng Bai, Yang Lv, Shuangshuang Xiong, Shuangjie Wu, Lin Qi, Shengnan Ren, Meiqi Zhu, Haijuan Dong, Hongtao Shen, Zhaoxing Li, Yinxue Zhu, Hui Ye, Haiping Hao, Yibei Xiao, Hua Xiang, Guoshun Luo

Journal: Bioorg Chem

PubMed ID: 37871388

Doi: 10.1016/j.bioorg.2023.106919

Products & Services: Proteins, Expression, Isolation and Analysis

CTNNBIP1-CLSTN1 functions as a housekeeping chimeric RNA and regulates cell proliferation through SERPINE2

Authors: Chen Chen, Fujun Qin, Sandeep Singh, Yue Tang, Hui Li

Journal: Cell Death Discov

PubMed ID: 37805599

Doi: 10.1038/s41420-023-01668-8

Products & Services: Proteins, Expression, Isolation and Analysis

becomes lethal to post-larvae shrimp via acquiring novel virulence factors

Authors: Shuang Liu, Wei Wang, Tianchang Jia, Lusheng Xin, Ting-Ting Xu, Chong Wang, Guosi Xie, Kun Luo, Jun Li, Jie Kong, Qingli Zhang

Journal: Microbiol Spectr

PubMed ID: 37850796

Doi: 10.1128/spectrum.00492-23

Products & Services: Proteins, Expression, Isolation and Analysis

Ablation of the GDP-fucose transporter suppresses lung cancer cell proliferation and migration by reducing expression of PD-L1

Authors: Yingshu Zhang, Nianzhu Zhang, Wanli Song, Sabiha Yousuf, Wenzhe Li

Journal: J Cancer

PubMed ID: 37928424

Doi: 10.7150/jca.84652

Products & Services: Proteins, Expression, Isolation and Analysis

generated antibodies guide thermostable ADDomer nanoparticle design for nasal vaccination and passive immunization against SARS-CoV-2

Authors: Dora Buzas, Adrian H Bunzel, Oskar Staufer, Emily J Milodowski, Grace L Edmunds, Joshua C Bufton, Beatriz V Vidana Mateo, Sathish K N Yadav, Kapil Gupta, Charlotte Fletcher, Maia K Williamson, Alexandra Harrison, Ufuk Borucu, Julien Capin, Ore Francis, Georgia Balchin, Sophie Hall, Mirella V Vega, Fabien Durbesson, Srikanth Lingappa, Renaud Vincentelli, Joe Roe, Linda Wooldridge, Rachel Burt, Ross J L Anderson, Adrian J Mulholland, Jonathan Hare, Mick Bailey, Andrew D Davidson, Adam Finn, David Morgan, Jamie Mann, Joachim Spatz, Frederic Garzoni, Christiane Schaffitzel, Imre Berger

Journal: Antib Ther

PubMed ID: 38075238

Doi: 10.1093/abt/tbad024

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Vaccination with post-translational modified, homocitrullinated peptides induces CD8 T-cell responses that mediate antitumor immunity

Authors: Sabaria Shah, Katherine W Cook, Peter Symonds, Juliane Weißer, Anne Skinner, Abdullah Al Omari, Samantha J Paston, Ian Pike, Lindy G Durrant, Victoria A Brentville

Journal: J Immunother Cancer

PubMed ID: 37857526

Doi: 10.1136/jitc-2023-006966

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Enhanced protective efficacy of a thermostable RBD-S2 vaccine formulation against SARS-CoV-2 and its variants

Authors: Nidhi Mittal, Sahil Kumar, Raju S Rajmani, Randhir Singh, Céline Lemoine, Virginie Jakob, Sowrabha Bj, Nayana Jagannath, Madhuraj Bhat, Debajyoti Chakraborty, Suman Pandey, Aurélie Jory, Suba Soundarya Sa, Harry Kleanthous, Patrice Dubois, Rajesh P Ringe, Raghavan Varadarajan

Journal: npj Vaccines

PubMed ID: 37880298

Doi: 10.1038/s41541-023-00755-2

Products & Services: Proteins, Expression, Isolation and Analysis

Plant miRNA bol-miR159 Regulates Gut Microbiota Composition in Mice: Evidence of the Crosstalk between Plant miRNAs and Intestinal Microbes

Authors: Qin Xu, Xinshu Qin, Yi Zhang, Ke Xu, Ying Li, Yinglei Li, Bangran Qi, Yan Li, Xingbin Yang, Xingyu Wang

Journal: J Agric Food Chem

PubMed ID: 37862127

Doi: 10.1021/acs.jafc.3c06104

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Functional characterization of a lytic polysaccharide monooxygenase from Schizophyllum commune that degrades non-crystalline substrates

Authors: Heidi Østby, Idd A Christensen, Karen Hennum, Anikó Várnai, Edith Buchinger, Siri Grandal, Gaston Courtade, Olav A Hegnar, Finn L Aachmann, Vincent G H Eijsink

Journal: Sci Rep

PubMed ID: 37833388

Doi: 10.1038/s41598-023-44278-1

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Emergent properties of melanin-inspired peptide/RNA condensates

Authors: Amit Netzer, Itai Katzir, Avigail Baruch Leshem, Michal Weitman, Ayala Lampel

Journal: Proc Natl Acad Sci U S A

PubMed ID: 37871222

Doi: 10.1073/pnas.2310569120

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CD8 T-cells target the Crimean-Congo haemorrhagic fever virus Gc protein to control the infection in wild-type mice

Authors: Deepashri Rao, Kimberly Meade-White, Shanna Leventhal, Evan Mihalakakos, Aaron Carmody, Heinz Feldmann, David W Hawman

Journal: EBioMedicine

PubMed ID: 37866114

Doi: 10.1016/j.ebiom.2023.104839

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A biotechnological approach for the production of new protein bioplastics

Authors: Francesca De Marchis, Tania Vanzolini, Elisa Maricchiolo, Michele Bellucci, Michele Menotta, Tomas Di Mambro, Annalisa Aluigi, Andrea Zattoni, Barbara Roda, Valentina Marassi, Rita Crinelli, Andrea Pompa

Journal: Biotechnol J

PubMed ID: 37801630

Doi: 10.1002/biot.202300363

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Inhibition of N-myristoyltransferase activity promotes androgen receptor degradation in prostate cancer

Authors: Omar Awad Alsaidan, Emmanuel Onobun, Chenming Ye, Lei Lou, Zanna Beharry, Zhong-Ru Xie, Iryna Lebedyeva, David Crich, Houjian Cai

Journal: Prostate

PubMed ID: 37905842

Doi: 10.1002/pros.24645

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RING induces cell cycle arrest and apoptosis in human breast cancer cells by regulating the HSF1/MT2A axis

Authors: Di Liu, Yize Guo, Qin Du, Yuxuan Zhu, Ya Guo

Journal: Exp Cell Res

PubMed ID: 37797799

Doi: 10.1016/j.yexcr.2023.113795

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Investigation of serum amyloid a within animal species focusing on the 1-25 amino acid region

Authors: Natalie G Horgan, Kendall B E Moore, Jessica S Fortin

Journal: Vet Q

PubMed ID: 37800590

Doi: 10.1080/01652176.2023.2267605

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Recovery of protein synthesis to assay DNA repair activity in transcribed genes in living cells and tissues

Authors: Melanie van der Woude, Carlota Davó-Martínez, Karen L Thijssen, Wim Vermeulen, Hannes Lans

Journal: Nucleic Acids Res

PubMed ID: 37522336

Doi: 10.1093/nar/gkad642

Products & Services: Proteins, Expression, Isolation and Analysis

Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease

Authors: Xingyu Zhang, Li Tang, Jiaolong Yang, Lanxia Meng, Jiehui Chen, Lingyan Zhou, Jiangyu Wang, Min Xiong, Zhentao Zhang

Journal: Nat Commun

PubMed ID: 37865646

Doi: 10.1038/s41467-023-42505-x

Products & Services: Proteins, Expression, Isolation and Analysis

Dihydropyrmidine dehydrogenase from Escherichia coli: Transient state analysis reveals both reductive activation prior to turnover and diminished substrate effector roles relative to the mammalian form

Authors: Tyler B Alt, Matthew R Hoag, Graham R Moran

Journal: Arch Biochem Biophys

PubMed ID: 37820757

Doi: 10.1016/j.abb.2023.109772

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular mechanism of decision-making in glycosaminoglycan biosynthesis

Authors: Douglas Sammon, Anja Krueger, Marta Busse-Wicher, Rhodri Marc Morgan, Stuart M Haslam, Benjamin Schumann, David C Briggs, Erhard Hohenester

Journal: Nat Commun

PubMed ID: 37828045

Doi: 10.1038/s41467-023-42236-z

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High-risk histological subtype-related FAM83A hijacked FOXM1 transcriptional regulation to promote malignant progression in lung adenocarcinoma

Authors: Wei Fei, Yan Yan, Guangjun Liu, Bo Peng, Yuanyuan Liu, Qiang Chen

Journal: PeerJ

PubMed ID: 37904848

Doi: 10.7717/peerj.16306

Products & Services: Recombinant Proteins

A Small RNA, SaaS, Promotes Salmonella Pathogenicity by Regulating Invasion, Intracellular Growth, and Virulence Factors

Authors: Lin-Lin Cai, Yun-Ting Xie , Hai-Jing Hu , Xing-Lian Xu , Hu-Hu Wang , Guang-Hong Zhou

Journal: Microbiol Spectr .

PubMed ID: 36688642

Doi: 10.1128/spectrum.02938-22

Products & Services: Proteins, Expression, Isolation and Analysis

UV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence

Authors: Alessio De Magis, Michaela Limmer, Venkat Mudiyam, David Monchaud, Stefan Juranek, Katrin Paeschke

Journal: Nat Commun

PubMed ID: 37872164

Doi: 10.1038/s41467-023-42494-x

Products & Services: Proteins, Expression, Isolation and Analysis

Requires the Type II Secretion System for Pathogenicity and Survival in Grapevine

Authors: Brian Ingel, Claudia Castro, Lindsey Burbank, Nancy Her, N Itzel De Anda, Hannah Way, Peng Wang, M Caroline Roper

Journal: Mol Plant Microbe Interact

PubMed ID: 37188464

Doi: 10.1094/MPMI-03-23-0027-R

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Aggregative adherence fimbriae form compact structures as seen by SAXS

Authors: Rie Jønsson, Alexander Björling, Søren Roi Midtgaard, Grethe Vestergaard Jensen, Nicholas Skar-Gislinge, Lise Arleth, Steve Matthews, Karen Angeliki Krogfelt, Håvard Jenssen

Journal: Sci Rep

PubMed ID: 37783694

Doi: 10.1038/s41598-023-42079-0

Products & Services: Proteins, Expression, Isolation and Analysis

A morpheein equilibrium regulates catalysis in phosphoserine phosphatase SerB2 from Mycobacterium tuberculosis

Authors: Elise Pierson, Florian De Pol, Marianne Fillet, Johan Wouters

Journal: Commun Biol

PubMed ID: 37817000

Doi: 10.1038/s42003-023-05402-z

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MiR-143-3p/FNDC5 axis: a novel regulator of insulin sensitivity

Authors: Biao Li, Ying Dong, Siyuan Hu, Tiancai Liu

Journal: Endocrine

PubMed ID: 37815745

Doi: 10.1007/s12020-023-03522-4

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An in vitro-transcribed circular RNA targets the mitochondrial inner membrane cardiolipin to ablate EIF4G2/PTBP1 pan-adenocarcinoma

Authors: Zunyong Feng, Xuanbo Zhang, Jing Zhou, Qiang Li, Liuxi Chu, Guangfu Di, Zhengyuan Xu, Qun Chen, Ming Wang, Xiaochun Jiang, Hongping Xia, Xiaoyuan Chen

Journal: Nat Cancer

PubMed ID: 37845485

Doi: 10.1038/s43018-023-00650-8

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Gcn5- and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae

Authors: Yu-Min Li, Yu-Chao Mei, Ao-Hui Liu, Ru-Xin Wang, Runfa Chen, Hai-Ning Du

Journal: Cell Rep

PubMed ID: 37796660

Doi: 10.1016/j.celrep.2023.113186

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Differential modulation of cellular phenotype and drug sensitivity by extracellular matrix proteins in primary and metastatic pancreatic cancer cells

Authors: Olalekan H Usman, Sampath Kumar, Reddick R Walker, Gengqiang Xie, Hyeje C Sumajit, AbdelAziz R Jalil, Subramanian Ramakrishnan, Lawrence J Dooling, Yue Julia Wang, Jerome Irianto

Journal: Mol Biol Cell

PubMed ID: 37903222

Doi: 10.1091/mbc.E23-02-0075

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Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases

Authors: Shaojie Cui, Anchal Ghai, Yaqin Deng, Shili Li, Ruihui Zhang, Christopher Egbulefu, Guosheng Liang, Samuel Achilefu, Jin Ye

Journal: Mol Cell

PubMed ID: 37863053

Doi: 10.1016/j.molcel.2023.09.025

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Propofol Promoted the Cell Growth and Epithelial Mesenchymal Transformation of the HTR-8/SVneo Cells through Targeting the METTL3 Mediated ZEB2

Authors: Long Cheng, Liang Zhao, Geng Wang