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Investigation of Immunostimulatory Effects of IFN-γ Cytokine and CD40 Ligand Costimulatory Molecule for Development of HIV-1 Therapeutic Vaccine Candidate

Authors: Fatemeh Heidarnejad, Azam Bolhassani, Soheila Ajdary, Alireza Milani, Seyed Amir Sadeghi

Journal: Adv Biol (Weinh)

PubMed ID: 37840398

Doi: 10.1002/adbi.202300402

Products & Services: Molecular Biology Reagents

Authentication of a lophotrochozoan adipokinetic hormone receptor in a Gastropod, Aplysia californica

Authors: Pei-San Tsai, Kelsey N Sanders, Xin Dai, David Plachetzki

Journal: Gen Comp Endocrinol

PubMed ID: 37865149

Doi: 10.1016/j.ygcen.2023.114393

Products & Services: Molecular Biology Reagents

A non-canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT)

Authors: Li Chen, Yikai Lu, Mengmeng Zhao, Junfang Xu, Yan Wang, Qinghua Xu, Yajuan Cao, Haipeng Liu

Journal: J Gene Med

PubMed ID: 37897251

Doi: 10.1002/jgm.3612

Products & Services: Proteins, Expression, Isolation and Analysis

Folic acid alleviated oxidative stress-induced telomere attrition and inhibited apoptosis of neurocytes in old rats

Authors: Dezheng Zhou, Yue Sun, Cuixia Dong, Zehao Wang, Jing Zhao, Zhenshu Li, Guowei Huang, Wen Li

Journal: Eur J Nutr

PubMed ID: 37870657

Doi: 10.1007/s00394-023-03266-x

Products & Services: Gene Synthesis

Antibodies elicited by Plasmodium falciparum circumsporozoite proteins lacking sequentially deleted C-terminal amino acids reveal mouse strain and epitopes specific differences

Authors: Clifford T H Hayashi, Yi Cao, Fidel Zavala, Hayk Simonyan, Colin N Young, Nirbhay Kumar

Journal: Vaccine

PubMed ID: 37827976

Doi: 10.1016/j.vaccine.2023.10.009

Products & Services: Gene Synthesis

DETECTION OF SARS-COV-2 NEUTRALIZING ANTIBODIES IN RETROPHARYNGEAL LYMPH NODE EXUDATES OF WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) FROM NEBRASKA, USA

Authors: Korakrit Poonsuk, Duan Loy, Rachael Birn, Bryan Buss, Matthew Donahue, Todd Nordeen, Kylie Sinclair, Luke Meduna, Bruce Brodersen, John Dustin Loy

Journal: J Wildl Dis

PubMed ID: 37768779

Doi: 10.7589/JWD-D-23-00005

Products & Services: Proteins, Expression, Isolation and Analysis

Expression of a SAG protein with a CAP domain from Eimeria necatrix and its role in invasion and immunoprotection

Authors: Feiyan Wang, Amin Zhang, Xuelian Fan, Qianqian Feng, Zhizhi Zhang, Dandan Liu, Shijie Su, Zhaofeng Hou, Jinjun Xu, Xilong Kang, Zhiming Pan, Hunjie Hu, Jianping Tao

Journal: Vet Parasitol

PubMed ID: 37931477

Doi: 10.1016/j.vetpar.2023.110060

Products & Services: Proteins, Expression, Isolation and Analysis

Flavivirus genome recoding by codon optimisation confers genetically stable in vivo attenuation in both mice and mosquitoes

Authors: Wei-Xin Chin, Hao Yuin Kong, Isabelle Xin Yu Zhu, Zi Yun Teo, Regina Faruk, Regina Ching Hua Lee, Si Xian Ho, Zhen Qin Aw, Bowen Yi, Xin Jun Hou, Antson Kiat Yee Tan, Thinesshwary Yogarajah, Roland G Huber, Yu Cai, Yue Wan, Justin Jang Hann Chu

Journal: PLoS Pathog

PubMed ID: 37883598

Doi: 10.1371/journal.ppat.1011753

Products & Services: Molecular Biology Reagents

The cell-end protein Tea4 spatially regulates hyphal branch initiation and appressorium remodeling in the blast fungus

Authors: Audra Mae Rogers, Rachel Taylor, Martin John Egan

Journal: Mol Biol Cell

PubMed ID: 37903237

Doi: 10.1091/mbc.E23-06-0214

Products & Services: PCR Cloning and Subcloning

Differential regulation of fibronectin expression and fibrillogenesis by autocrine TGF-β1 signaling in malignant and benign mammary epithelial cells

Authors: Michael M Sofroniou, Christopher A Lemmon

Journal: Int J Biochem Cell Biol

PubMed ID: 37866655

Doi: 10.1016/j.biocel.2023.106478

Products & Services: Stable Cell Lines

Modulating biofilm can potentiate activity of novel plastic-degrading enzymes

Authors: Sophie A Howard, Ronan R McCarthy

Journal: NPJ Biofilms Microbiomes

PubMed ID: 37788986

Doi: 10.1038/s41522-023-00440-1

Products & Services: Gene Synthesis

Development of CRISPR/Cas9-Based Genome Editing Tools for Polyploid Yeast Cyberlindnera jadinii and Its Application in Engineering Heterologous Steroid-Producing Strains

Authors: Lishan Gu, Rongxin Zhang, Xuqian Fan, Yu Wang, Kaiyu Ma, Jingjing Jiang, Gen Li, Honglei Wang, Feiyu Fan, Xueli Zhang

Journal: ACS Synth Biol

PubMed ID: 37816156

Doi: 10.1021/acssynbio.3c00278

Products & Services: Codon Optimization

Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura

Authors: Zhitao Wang, Xinhui Zhang, Xueqin Lu, Peng Peng, Huiru Wang, Shanglong Feng, Li Zhou

Journal: Hematology

PubMed ID: 37850618

Doi: 10.1080/16078454.2023.2269513

Products & Services: Proteins, Expression, Isolation and Analysis

Modular multiwell viscoelastic hydrogel platform for two- and three-dimensional cell culture applications

Authors: Mackenzie L Skelton, James L Gentry, Leilani R Astrab, Joshua A Goedert, E Brynn Earl, Emily L Pham, Tanvi Bhat, Steven R Caliari

Journal: biorxiv

PubMed ID: 37873098

Doi: 10.1101/2023.10.09.561449

Products & Services: Proteins, Expression, Isolation and Analysis

Tafluprost promotes axon regeneration after optic nerve crush via Zn-mTOR pathway

Authors: Siting Wu, Canying Liu, Jiahui Tang, Caiqing Wu, Qi Zhang, Zhe Liu, Jiaxu Han, Jingfei Xue, Jicheng Lin, Yuze Chen, Jinpeng Yang, Yehong Zhuo, Yiqing Li

Journal: Neuropharmacology

PubMed ID: 37832634

Doi: 10.1016/j.neuropharm.2023.109746

Products & Services: Proteins, Expression, Isolation and Analysis

PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes

Authors: Binglin Zhu, Emily Fisher, Li Li, Ping Zhong, Zhen Yan, Jian Feng

Journal: Stem Cell Reports

PubMed ID: 37832540

Doi: 10.1016/j.stemcr.2023.09.012

Products & Services: Molecular Biology Reagents

Hem25p is required for mitochondrial IPP transport in fungi

Authors: Jonathan Tai, Rachel M Guerra, Sean W Rogers, Zixiang Fang, Laura K Muehlbauer, Evgenia Shishkova, Katherine A Overmyer, Joshua J Coon, David J Pagliarini

Journal: Nat Cell Biol

PubMed ID: 37813972

Doi: 10.1038/s41556-023-01250-5

Products & Services: Codon Optimization

Endogenous Rab38 regulates LRRK2's membrane recruitment and substrate Rab phosphorylation in melanocytes

Authors: Alexandra Unapanta , Farbod Shavarebi , Jacob Porath , Yiyi Shen , Carson Balen , Albert Nguyen , Josh Tseng , Weng Si Leong , Michelle Liu , Pawel Lis , Santiago M Di Pietro , Annie Hiniker

Journal: J Biol Chem .

PubMed ID: 37625589

Doi: 10.1016/j.jbc.2023.105192

Products & Services: Proteins, Expression, Isolation and Analysis

A two-arm analysis of the immune response to heterologous boosting of inactivated SARS-CoV-2 vaccines

Authors: Arnone Nithichanon, Ludthawun Kamuthachad, Kanin Salao, Wisitsak Phoksawat, Chatcharin Kamsom, Surasakdi Wongratanacheewin, Chonlatip Pipattanaboon, Sakawrat Kanthawong, Umaporn Yordpratum, Sirinart Aromseree, Atibordee Meesing, Piroon Mootsikapun, Steven W Edwards, Supranee Phanthanawiboon

Journal: Sci Rep

PubMed ID: 37907584

Doi: 10.1038/s41598-023-46053-8

Products & Services: Molecular Biology Reagents

Improved Stability and Manufacturability of Nucleocapsid Antigens for SARS-CoV2 Diagnostics through Protein Engineering

Authors: Esha Shukla, Lipsa Choudhury, Saurabh Rastogi, Arshmeet Chawla, Sanghati Bhattacharya, Umesh Kaushik, Manan Mittal, Anurag Singh Rathore, Gaurav Pandey

Journal: Biomolecules

PubMed ID: 37892206

Doi: 10.3390/biom13101524

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Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control

Authors: Ryan D Mouery, Carolyn Hsu, Thomas Bonacci, Derek L Bolhuis, Xianxi Wang, Christine A Mills, E Drew Toomer, Owen G Canterbury, Kevin C Robertson, Timothy B Branigan, Nicholas G Brown, Laura E Herring, Michael J Emanuele

Journal: biorxiv

PubMed ID: 37873169

Doi: 10.1101/2023.10.11.561963

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Quercetin ameliorates ferroptosis of rat cardiomyocytes via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate sepsis‑induced cardiomyopathy

Authors: Xin Lin, Xiaoxia Zhao, Qingfeng Chen, Xiaoyue Wang, Yongya Wu, Hao Zhao

Journal: Int J Mol Med

PubMed ID: 37859612

Doi: 10.3892/ijmm.2023.5319

Products & Services: Proteins, Expression, Isolation and Analysis

Specific Nucleotides in the Common Region of the Begomovirus Tomato Rugose Mosaic Virus (ToRMV) Are Responsible for the Negative Interference over Tomato Severe Rugose Virus (ToSRV) in Mixed Infection

Authors: Angélica M Nogueira, Tarsiane M C Barbosa, Ayane F F Quadros, Anelise F Orílio, Marcela C J Bigão, César A D Xavier, Camila G Ferro, Francisco Murilo Zerbini

Journal: Viruses

PubMed ID: 37896851

Doi: 10.3390/v15102074

Products & Services: Recombinant Proteins

Lactate promotes intracellular replication and systemic infection via driving macrophage M2 polarization

Authors: Xinyue Wang, Bin Yang, Shuangshuang Ma, Xiaolin Yan, Shuai Ma, Hongmin Sun, Yuyang Sun, Lingyan Jiang

Journal: Microbiol Spectr

PubMed ID: 37796020

Doi: 10.1128/spectrum.02253-23

Products & Services: PCR Cloning and Subcloning

Identification and production of novel potential pathogen-specific biomarkers for diagnosis of histoplasmosis

Authors: Juan David Puerta-Arias, Juan Pablo Isaza Agudelo, Tonny Williams Naranjo Preciado

Journal: Microbiol Spectr

PubMed ID: 37882565

Doi: 10.1128/spectrum.00939-23

Products & Services: Recombinant Proteins

Nucleic acid-triggered NADase activation of a short prokaryotic Argonaute

Authors: Xiaopan Gao , Kun Shang , Kaixiang Zhu , Linyue Wang , Zhixia Mu , Xingke Fu , Xia Yu , Bo Qin , Hongtao Zhu , Wei Ding , Sheng Cui

Journal: Nature .

PubMed ID: 37783228

Doi: 10.1038/s41586-023-06665-6

Products & Services: DNA Sequencing

Plant-Based Meat Analogues Weaken Gastrointestinal Digestive Function and Show Less Digestibility Than Real Meat in Mice

Authors: Yunting Xie , Linlin Cai , Zhiji Huang , Kai Shan , Xinglian Xu , Guanghong Zhou , Chunbao Li

Journal: J Agric Food Chem .

PubMed ID: 36070521

Doi: 10.1021/acs.jafc.2c04246

Products & Services: Gene Synthesis

Single Amino Acid Mutation Decouples Photochemistry of the BLUF Domain from the Enzymatic Function of OaPAC and Drives the Enzyme to a Switched-on State

Authors: Jinnette Tolentino Collado, Emoke Bodis, Jonatan Pasitka, Mihaly Szucs, Zsuzsanna Fekete, Nikolett Kis-Bicskei, Elek Telek, Kinga Pozsonyi, Sofia M Kapetanaki, Greg Greetham, Peter J Tonge, Stephen R Meech, Andras Lukacs

Journal: J Mol Biol

PubMed ID: 37827329

Doi: 10.1016/j.jmb.2023.168312

Products & Services: Proteins, Expression, Isolation and Analysis

Rational Design of Taxadiene Hydroxylase by Ancestral Enzyme Construction and the Elucidation of Key Amino Acids

Authors: Zihan Zhang, Longhao Huang, Zhi-Jun Zhang, Jian-He Xu, Hui-Lei Yu

Journal: Biochemistry

PubMed ID: 37902563

Doi: 10.1021/acs.biochem.3c00411

Products & Services: Proteins, Expression, Isolation and Analysis

FHL1 promotes chikungunya and o'nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design

Authors: Wern Hann Ng, Xiang Liu, Zheng L Ling, Camilla N O Santos, Lucas S Magalhães, Andrew J Kueh, Marco J Herold, Adam Taylor, Joseph R Freitas, Sandra Koit, Sainan Wang, Andrew R Lloyd, Mauro M Teixeira, Andres Merits, Roque P Almeida, Nicholas J C King, Suresh Mahalingam

Journal: Nat Commun

PubMed ID: 37884534

Doi: 10.1038/s41467-023-42330-2

Products & Services: Proteins, Expression, Isolation and Analysis

Preclinical efficacy of a cell division protein candidate gonococcal vaccine identified by artificial intelligence

Authors: Sunita Gulati, Andreas Holm Mattsson, Sophie Schussek, Bo Zheng, Rosane B DeOliveira, Jutamas Shaughnessy, Lisa A Lewis, Peter A Rice, Pär Comstedt, Sanjay Ram

Journal: MBio

PubMed ID: 37905891

Doi: 10.1128/mbio.02500-23

Products & Services: Proteins, Expression, Isolation and Analysis

Biochemical and biophysical properties of a rare TTRA81V mutation causing mild transthyretin amyloid cardiomyopathy

Authors: Qiuyan Sha, Yanli Zhang, Mengdie Wang, Jialu Sun, Yunlong Zhang, Xinxin Zhang, Ning Wang, Yu Liu, Ying Liu

Journal: ESC Heart Fail

PubMed ID: 37827496

Doi: 10.1002/ehf2.14543

Products & Services: Proteins, Expression, Isolation and Analysis

Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer

Authors: Giuditta Guerrini, Dora Mehn, Francesco Fumagalli, Sabrina Gioria, Mattia Pedotti, Luca Simonelli, Filippo Bianchini, Davide F Robbiani, Luca Varani, Luigi Calzolai

Journal: Int J Mol Sci

PubMed ID: 37834322

Doi: 10.3390/ijms241914875

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Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Authors: Payton A-B Weidenbacher, Mrinmoy Sanyal, Natalia Friedland, Shaogeng Tang, Prabhu S Arunachalam, Mengyun Hu, Ozan S Kumru, Mary Kate Morris, Jane Fontenot, Lisa Shirreff, Jonathan Do, Ya-Chen Cheng, Gayathri Vasudevan, Mark B Feinberg, Francois J Villinger, Carl Hanson, Sangeeta B Joshi, David B Volkin, Bali Pulendran, Peter S Kim

Journal: Nat Commun

PubMed ID: 37798288

Doi: 10.1038/s41467-023-42061-4

Products & Services: Peptide Synthesis

Industry updates from the field of stem cell research and regenerative medicine in August 2023

Authors: Dusko Ilic, Mirjana Liovic

Journal: Regen Med

PubMed ID: 37786963

Doi: 10.2217/rme-2023-0181

Products & Services: Proteins, Expression, Isolation and Analysis

LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric α-synuclein through NF-κB pathway

Authors: Kai-Jie He, Jin-Bao Zhang, Jun-Yi Liu, Feng-Lun Zhao, Xiao-Yu Yao, Yu-Ting Tang, Jin-Ru Zhang, Xiao-Yu Cheng, Li-Fang Hu, Fen Wang, Chun-Feng Liu

Journal: iScience

PubMed ID: 37876795

Doi: 10.1016/j.isci.2023.108130

Products & Services: Molecular Biology Reagents

Development and characterization of a prototypic pan-amyloid clearing agent - a novel murine peptide-immunoglobulin fusion

Authors: James S Foster, Manasi Balachandran, Trevor J Hancock, Emily B Martin, Sallie Macy, Craig Wooliver, Tina Richey, Alan Stuckey, Angela D Williams, Joseph W Jackson, Stephen J Kennel, Jonathan S Wall

Journal: Front Immunol

PubMed ID: 37854603

Doi: 10.3389/fimmu.2023.1275372

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Whole-genome sequence and mass spectrometry study of the snow blight fungus Phacidium infestans (Karsten) DSM 5139 growing at freezing temperatures

Authors: C Zerouki, K Chakraborty, S Kuittinen, A Pappinen, O Turunen

Journal: Mol Genet Genomics

PubMed ID: 37815644

Doi: 10.1007/s00438-023-02073-7

Products & Services: Combinatorial DNA Libraries

Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2

Authors: Rodrigo Lázaro-Gorines, Patricia Pérez, Ignacio Heras-Murillo, Irene Adán-Barrientos, Guillermo Albericio, David Astorgano, Sara Flores, Joanna Luczkowiak, Nuria Labiod, Seandean L Harwood, Alejandro Segura-Tudela, Laura Rubio-Pérez, Yudhi Nugraha, Xiaoran Shang, Yuxing Li, Carlos Alfonso, Kaylin A Adipietro, Dinendra L Abeyawardhane, Rocío Navarro, Marta Compte, Wenbo Yu, Alexander D MacKerell, Laura Sanz, David J Weber, Francisco J Blanco, Mariano Esteban, Edwin Pozharski, Raquel Godoy-Ruiz, Inés G Muñoz, Rafael Delgado, David Sancho, Juan García-Arriaza, Luis Álvarez-Vallina

Journal: Adv Sci (Weinh)

PubMed ID: 37863812

Doi: 10.1002/advs.202304818

Products & Services: Plasmids for SARS-CoV-2 Detection and Research

Examining the Potential Formation of Ternary DNA Complexes with Chromium‑Cysteine, Chromium-Ascorbate, and Chromium-Glutathione and Implications for Their Carcinogenicity

Authors: Sydney Marchi , Emma Lankford , Bradley Dorin , Eilidh Drummond , Sumner C Thomas , Stephen A Woski , John B Vincent

Journal: Biol Trace Elem Res .

PubMed ID: 36662348

Doi: 10.1007/s12011-023-03573-8

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Molecular basis of methyl-salicylate-mediated plant airborne defence

Authors: Qian Gong , Yunjing Wang , Linfang He , Fan Huang , Danfeng Zhang , Yan Wang , Xiang Wei , Meng Han , Haiteng Deng , Lan Luo , Feng Cui , Yiguo Hong, Yule Liu

Journal: Nature .

PubMed ID: 37704724

Doi: 10.1038/s41586-023-06533-3

Products & Services: Proteins, Expression, Isolation and Analysis

Are Histidine Kinases of Arbuscular Mycorrhizal Fungi Involved in the Response to Ethylene and Cytokinins?

Authors: Ayla Mongès, Hajar Yaakoub, Baptiste Bidon, Gaëlle Glévarec, François Héricourt, Sabine Carpin, Lucie Chauderon, Lenka Drašarová, Lukáš Spíchal, Brad M Binder, Nicolas Papon, Soizic Rochange

Journal: Mol Plant Microbe Interact .

PubMed ID: 37851914

Doi: 10.1094/MPMI-05-23-0056-R

Products & Services: Gene Synthesis

A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels

Authors: Jian Zhou, Claudia Cattoglio, Yingyao Shao, Harini P Tirumala, Carlo Vetralla, Sameer S Bajikar, Yan Li, Hu Chen, Qi Wang, Zhenyu Wu, Bing Tang, Mahla Zahabiyon, Aleksandar Bajic, Xiangling Meng, Jack J Ferrie, Anel LaGrone, Ping Zhang, Jean J Kim, Jianrong Tang, Zhandong Liu, Xavier Darzacq, Nathaniel Heintz, Robert Tjian, Huda Y Zoghbi

Journal: Genes Dev

PubMed ID: 37890975

Doi: 10.1101/gad.350733.123

Products & Services: Proteins, Expression, Isolation and Analysis

A critical role for iron and zinc homeostatic systems in the evolutionary adaptation of to metal restriction

Authors: Joy R Paterson, Joshua M Wadsworth, Ping Hu, Gary J Sharples

Journal: Microb Genom

PubMed ID: 38054971

Doi: 10.1099/mgen.0.001153

Products & Services: Proteins, Expression, Isolation and Analysis

Overexpressing CsPSY1 Gene of Tea Plant, Encoding a Phytoene Synthase, Improves α-Carotene and β-Carotene Contents in Carrot

Authors: Jing-Wen Li, Ping Zhou, Yuan-Jie Deng, Zhi-Hang Hu, Xing-Hui Li, Xuan Chen, Ai-Sheng Xiong, Jing Zhuang

Journal: Mol Biotechnol

PubMed ID: 37897587

Doi: 10.1007/s12033-023-00942-5

Products & Services: Proteins, Expression, Isolation and Analysis

ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1

Authors: Karin Enell Smith, Sara Fritzell, Anneli Nilsson, Karin Barchan, Anna Rosén, Lena Schultz, Laura Varas, Anna Säll, Nadia Rose, Maria Håkansson, Laura von Schantz, Peter Ellmark

Journal: Cancer Immunol Immunother

PubMed ID: 37796298

Doi: 10.1007/s00262-023-03548-7

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Binding mechanism and biological effects of flavone DYRK1A inhibitors for the design of new antidiabetics

Authors: Katarzyna Pustelny, Przemyslaw Grygier, Agata Barzowska, Barbara Pucelik, Alex Matsuda, Krzysztof Mrowiec, Emilia Slugocka, Grzegorz M Popowicz, Grzegorz Dubin, Anna Czarna

Journal: Sci Rep

PubMed ID: 37872245

Doi: 10.1038/s41598-023-44810-3

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β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

Authors: Carole Daly, Akim Abdul Guseinov, Hyunggu Hahn, Adam Wright, Irina G Tikhonova, Alex Rojas Bie Thomsen, Bianca Plouffe

Journal: Elife

PubMed ID: 37855711

Doi: 10.7554/eLife.87754

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Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina

Authors: Heonuk Jeong, Deokho Lee, Xiaoyan Jiang, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara

Journal: Sci Rep

PubMed ID: 37857760

Doi: 10.1038/s41598-023-44983-x

Products & Services: Gene Synthesis

Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease

Authors: Takashi Kei Kishimoto, Max Fournier, Alicia Michaud, Gina Rizzo, Christopher Roy, Teresa Capela, Natasha Nukolova, Ning Li, Liam Doyle, Fen-Ni Fu, Derek VanDyke, Peter G Traber, Jamie B Spangler, Sheldon S Leung, Petr O Ilyinskii

Journal: J Autoimmun

PubMed ID: 37844543

Doi: 10.1016/j.jaut.2023.103125

Products & Services: Proteins, Expression, Isolation and Analysis

Selection, activity, and nuclease stabilization of cross-neutralizing DNA aptamers targeting HSV-1 and HSV-2

Authors: Michael D Schump, David I Bernstein, Fernando J Bravo, Charles P Neff

Journal: Virology

PubMed ID: 37925791

Doi: 10.1016/j.virol.2023.109916

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Aptabinding of tumor necrosis factor-α (TNFα) inhibits its proinflammatory effects and alleviates islet inflammation

Authors: Roaa Mahmoud, Jagan Kalivarathan, Abdul J Castillo, Sasha Wang, Brian Fuglestad, Mazhar A Kanak, Soma Dhakal

Journal: Biotechnol J

PubMed ID: 37772688

Doi: 10.1002/biot.202300374

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GhL1L1 regulates the contents of unsaturated fatty acids by activating the expression of GhFAD2 genes in cotton

Authors: Dandan Yue, Xuyang Hao, Bei Han, Jiao Xu, Weinan Sun, Xiaoping Guo, Xianlong Zhang, Xiyan Yang

Journal: Gene

PubMed ID: 37839764

Doi: 10.1016/j.gene.2023.147899

Products & Services: PCR Cloning and Subcloning

A newly identified ferritin L-subunit variant results in increased proteasomal subunit degradation, impaired complex assembly, and severe hypoferritinemia

Authors: Dayana Shagidov, Noga Guttmann-Raviv, Séverine Cunat, Liora Frech, Muriel Giansily-Blaizot, Niraj Ghatpande, Gili Abelya, Gabriel A Frank, Patricia Aguilar Martinez, Esther G Meyron-Holtz

Journal: Am J Hematol

PubMed ID: 37867341

Doi: 10.1002/ajh.27124

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of a thermostable Cas12a ortholog

Authors: Jing Wu, Pan Gao, Yajing Shi, Caixiang Zhang, Xiaohan Tong, Huidi Fan, Xi Zhou, Ying Zhang, Hao Yin

Journal: Cell Insight

PubMed ID: 38047138

Doi: 10.1016/j.cellin.2023.100126

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A circRNA therapy based on Rnf103 to inhibit Vibrio anguillarum infection

Authors: Weiwei Zheng, Xing Lv, Yaqi Tao, Yanqiu Cui, Xiangxiang Zhu, Tongtong Zhu, Tianjun Xu

Journal: Cell Rep

PubMed ID: 37874674

Doi: 10.1016/j.celrep.2023.113314

Products & Services: DNA Sequencing

Genistein alleviates chronic heat stress-induced lipid metabolism disorder and mitochondrial energetic dysfunction by activating the GPR30-AMPK-PGC-1α signaling pathways in the livers of broiler chickens

Authors: Longlong Li, Ze Lu, Yulei Wang, Ying Yang, Huihui Wang, Haitian Ma

Journal: Poult Sci

PubMed ID: 37984004

Doi: 10.1016/j.psj.2023.103251

Products & Services: Proteins, Expression, Isolation and Analysis

Condensation of the N-terminal domain of human topoisomerase 1 is driven by electrostatic interactions and tuned by its charge distribution

Authors: Greta Bianchi, Marco Mangiagalli, Diletta Ami, Junaid Ahmed, Silvia Lombardi, Sonia Longhi, Antonino Natalello, Peter Tompa, Stefania Brocca

Journal: Int J Biol Macromol

PubMed ID: 38287572

Doi: 10.1016/j.ijbiomac.2023.127754

Products & Services: Proteins, Expression, Isolation and Analysis

A 3D-printed blood-brain barrier model with tunable topology and cell-matrix interactions

Authors: Louis S Paone , Mohammed Mehdi Benmassaoud , Aidan Curran , Sebastián L Vega , Peter A Galie

Journal: Biofabrication .

PubMed ID: 37820611

Doi: 10.1088/1758-5090/ad0260

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Unfolding of an RNA G-quadruplex motif in the negative strand genome of porcine reproductive and respiratory syndrome virus by host and viral helicases to promote viral replication

Authors: Puxian Fang, Congbao Xie, Ting Pan, Ting Cheng, Wei Chen, Sijin Xia, Tong Ding, Junkang Fang, Yanrong Zhou, Liurong Fang, Dengguo Wei, Shaobo Xiao

Journal: Nucleic Acids Res

PubMed ID: 37739415

Doi: 10.1093/nar/gkad759

Products & Services: Proteins, Expression, Isolation and Analysis

Intervention of AXL in EGFR Signaling via Phosphorylation and Stabilization of MIG6 in Non-Small Cell Lung Cancer

Authors: Ya-Yu Yang, Sheng-Chieh Lin, Jong-Ding Lay, Chun-Yu Cho, Te-Hsuan Jang, Hsiu-Ying Ku, Chih-Jung Yao, Shuang-En Chuang

Journal: Int J Mol Sci

PubMed ID: 37834326

Doi: 10.3390/ijms241914879

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A spacer design strategy for CRISPR-Cas12f1 with single-nucleotide polymorphism mutation resolution capability and its application in the mutations diagnosis of pathogens

Authors: Panqi Gao, Maoyi Yang, Yi Chen, Jun Yan, Miaomiao Han, Haijun Deng, Keli Qian, Jiandong Yang, Yaoqin Lu, Ling Zhou, Ailong Huang, Xiaosong Li, Wanyan Deng, Quanxin Long

Journal: J Med Virol

PubMed ID: 37855689

Doi: 10.1002/jmv.29189

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New twists of a TAIL: novel insights into the histone binding properties of a highly conserved PHD finger cluster within the MLR family of H3K4 mono-methyltransferases

Authors: Claudia B Zraly, Richard Schultz, Manuel O Diaz, Andrew K Dingwall

Journal: Nucleic Acids Res

PubMed ID: 37638761

Doi: 10.1093/nar/gkad698

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Vγ9+Vδ2+ T cell control of Listeria monocytogenes growth in infected epithelial cells requires butyrophilin 3A genes

Authors: Katrin Fischer, Michaela Bradlerova, Thomas Decker, Verena Supper

Journal: Sci Rep

PubMed ID: 37903831

Doi: 10.1038/s41598-023-45587-1

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STT3A-mediated viral N-glycosylation underlies the tumor selectivity of oncolytic virus M1

Authors: Deli Song, Xudong Jia, Yuanzhu Gao, Tong Xiao, Jia Dan, Runling Shen, Jing Cai, Jiankai Liang, Wenbo Zhu, Jun Hu, Guangmei Yan, Qinfen Zhang, Yuan Lin

Journal: Oncogene

PubMed ID: 37864032

Doi: 10.1038/s41388-023-02872-7

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Therapeutic effect of exosomes derived from hepatocyte-growth-factor-overexpressing adipose mesenchymal stem cells on liver injury

Authors: Liushenyan Yu, Junchao Xue, Yanyan Wu, Hanyu Zhou

Journal: Folia Histochem Cytobiol

PubMed ID: 37787035

Doi: 10.5603/fhc.95291

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Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients

Authors: Christa Lichtensteiger, Maximilian Koblischke, Fiamma Berner, Ann-Kristin Jochum, Tobias Sinnberg, Beatrice Balciunaite, Mette-Triin Purde, Vincent Walter, Marie-Therese Abdou, Kathrin Hofmeister, Philipp Kohler, Pietro Vernazza, Werner C Albrich, Christian R Kahlert, Alexander Zoufaly, Marianna T Traugott, Lukas Kern, Urs Pietsch, Gian-Reto Kleger, Miodrag Filipovic, Manfred Kneilling, Antonio Cozzio, Oltin Pop, David Bomze, Andreas Bergthaler, Omar Hasan Ali, Judith Aberle, Lukas Flatz

Journal: J Autoimmun

PubMed ID: 37826919

Doi: 10.1016/j.jaut.2023.103118

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A Polyvalent Adhesin-Toxoid Multiepitope-Fusion-Antigen-Induced Functional Antibodies against Five Enterotoxigenic Adhesins (CS7, CS12, CS14, CS17, and CS21) but Not Enterotoxins (LT and STa)

Authors: Siqi Li, Hyesuk Seo, Ipshita Upadhyay, Weiping Zhang

Journal: Microorganisms

PubMed ID: 37894131

Doi: 10.3390/microorganisms11102473

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Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19

Authors: Gang Ye, Ruangang Pan, Fan Bu, Jian Zheng, Alise Mendoza, Wei Wen, Lanying Du, Benjamin Spiller, Brian E Wadzinski, Bin Liu, Stanley Perlman, Fang Li

Journal: J Virol

PubMed ID: 37855638

Doi: 10.1128/jvi.01448-23

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Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis

Authors: Alžběta Motyčková, Luboš Voleman, Vladimíra Najdrová, Lenka Arbonová, Martin Benda, Vít Dohnálek, Natalia Janowicz, Ronald Malych, Róbert Šuťák, Thijs J G Ettema, Staffan Svärd, Courtney W Stairs, Pavel Doležal

Journal: PLoS Pathog

PubMed ID: 37792908

Doi: 10.1371/journal.ppat.1010773

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Molecular insights into the HLA-B35 molecules' classification associated with HIV control

Authors: Christian A Lobos, Demetra Sm Chatzileontiadou, Bonin Sok, Coral-Ann Almedia, Hanim Halim, Lloyd D'Orsogna, Stephanie Gras

Journal: Immunol Cell Biol

PubMed ID: 37811811

Doi: 10.1111/imcb.12698

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The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection

Authors: Déborah Lécuyer, Roberta Nardacci, Désirée Tannous, Emie Gutierrez-Mateyron, Aurélia Deva Nathan, Frédéric Subra, Cristina Di Primio, Paola Quaranta, Vanessa Petit, Clémence Richetta, Ali Mostefa-Kara, Franca Del Nonno, Laura Falasca, Romain Marlin, Pauline Maisonnasse, Julia Delahousse, Juliette Pascaud, Eric Deprez, Marie Naigeon, Nathalie Chaput, Angelo Paci, Véronique Saada, David Ghez, Xavier Mariette, Mario Costa, Mauro Pistello, Awatef Allouch, Olivier Delelis, Mauro Piacentini, Roger Le Grand, Jean-Luc Perfettini

Journal: Front Immunol

PubMed ID: 37920468

Doi: 10.3389/fimmu.2023.1270081

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A novel recombinant S-based subunit vaccine induces protective immunity against porcine deltacoronavirus challenge in piglets

Authors: Jizong Li, Shuqing Zhao, Baotai Zhang, Jin Huang, Qi Peng, Li Xiao, Xuesong Yuan, Rongli Guo, Jinzhu Zhou, Baochao Fan, Tao Xue, Xuejiao Zhu, Chuanmin Liu, Xing Zhu, Lili Ren, Bin Li

Journal: J Virol

PubMed ID: 37846983

Doi: 10.1128/jvi.00958-23

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Diversity of rhodopsin cyclases in zoospore-forming fungi

Authors: Matthias Broser, Wayne Busse, Anika Spreen, Maila Reh, Yinth Andrea Bernal Sierra, Songhwan Hwang, Tillmann Utesch, Han Sun, Peter Hegemann

Journal: Proc Natl Acad Sci U S A

PubMed ID: 37871207

Doi: 10.1073/pnas.2310600120

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Construction and functional verification of size-reduced plasmids based on TMP resistance gene

Authors: Chun-Cao Li, Rui Hu, Xiu-Min Hua, Yi-Xuan Ni, Lu Ge, Lu Zhang, Wen Yu, Ni-Xin Hao, Hui Xia, Qiang Fang, Zhi-Yong Tao

Journal: Microbiol Spectr

PubMed ID: 37905802

Doi: 10.1128/spectrum.01206-23

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Structural and dynamical changes of the Streptococcus gordonii metalloregulatory ScaR protein induced by Mn ion binding

Authors: Katarina Radman, Zoe Jelić Matošević, Dijana Žilić, Ivo Crnolatac, Nikola Bregović, Marina Kveder, Ivo Piantanida, Pedro A Fernandes, Ivana Leščić Ašler, Branimir Bertoša

Journal: Int J Biol Macromol

PubMed ID: 37866578

Doi: 10.1016/j.ijbiomac.2023.127572

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Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes

Authors: Madeeha Ghazi, Shivangi Khanna, Yogaspoorthi Subramaniam, Jeyashri Rengaraju, Farina Sultan, Iti Gupta, Kanupriya Sharma, Sudhir Chandna, Rajesh S Gokhale, Vivek T Natarajan

Journal: Nucleic Acids Res

PubMed ID: 37697436

Doi: 10.1093/nar/gkad704

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Dual immunization with CdtB protein and flagellin epitope offers augmented protection against enteric fever in mice

Authors: Shania Vij, Reena Thakur, Raghwendra Pratap Singh, Rashmi Kumar, Preeti Pathania, Varsha Gupta, Chander Raman Suri, Praveen Rishi

Journal: Life Sci

PubMed ID: 37918629

Doi: 10.1016/j.lfs.2023.122216

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Cell-Permeable Stimuli-Responsive Ubiquitin Probe for Time- Resolved Monitoring of Substrate Ubiquitination in Live Cells

Authors: Lu-Jun Liang, Yu Wang, Xiao Hua, Rujing Yuan, Qiong Xia, Rongtian Wang, Chuntong Li, Guo-Chao Chu, Lei Liu, and Yi-Ming Li

Journal: JACS Au

Doi: 10.1021/jacsau.3c00421

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A thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering

Authors: Zhiheng Yang , Zilong Li , Bixiao Li , Ruihong Bu , Gao-Yi Tan , Zhengduo Wang , Hao Yan , Zhenguo Xin , Guojian Zhang , Ming Li , Hua Xiang, Lixin Zhang , Weishan Wang

Journal: Nat Commun .

PubMed ID: 37794017

Doi: 10.1038/s41467-023-41973-5

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Histone Abundance Quantification via Flow Cytometry of Htb2-GFP Allows Easy Monitoring of Cell Cycle Perturbations in Living Yeast Cells, Comparable to Standard DNA Staining

Authors: Maria V Kulakova, Eslam S M O Ghazy, Fedor Ryabov, Yaroslav M Stanishevskiy, Michael O Agaphonov, Alexander I Alexandrov

Journal: J Fungi (Basel)

PubMed ID: 37888289

Doi: 10.3390/jof9101033

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Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization

Authors: Rajesh P Ringe, Philippe Colin, Gabriel Ozorowski, Joel D Allen, Anila Yasmeen, Gemma E Seabright, Jeong Hyun Lee, Aleksandar Antanasijevic, Kimmo Rantalainen, Thomas Ketas, John P Moore, Andrew B Ward, Max Crispin, P J Klasse

Journal: PLoS Pathog

PubMed ID: 37903160

Doi: 10.1371/journal.ppat.1011601

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VP2 residue N142 of coxsackievirus A10 is critical for the interaction with KREMEN1 receptor and neutralizing antibodies and the pathogenicity in mice

Authors: Xue Li, Zeyu Liu, Xingyu Yan, Yuan Tian, Kexin Liu, Yue Zhao, Jiang Shao, Pei Hao, Chao Zhang

Journal: PLoS Pathog

PubMed ID: 37788227

Doi: 10.1371/journal.ppat.1011662

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One ring closer to a closure: the crystal structure of the ES hydroxymethylbilane synthase intermediate

Authors: Helene J Bustad, Marthe S Christie, Mikko Laitaoja, Aasne K Aarsand, Aurora Martinez, Janne Jänis, Juha P Kallio

Journal: FEBS J

PubMed ID: 37863644

Doi: 10.1111/febs.16982

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Improved prime editing allows for routine predictable gene editing in Physcomitrium patens

Authors: Pierre-François Perroud, Anouchka Guyon-Debast, Josep M Casacuberta, Wyatt Paul, Jean-Philippe Pichon, David Comeau, Fabien Nogué

Journal: J Exp Bot

PubMed ID: 37243510

Doi: 10.1093/jxb/erad189

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The Functional Characteristics and Soluble Expression of Saffron CCD2

Authors: Ying Wang, Siqi Li, Ze Zhou, Lifen Sun, Jing Sun, Chuanpu Shen, Ranran Gao, Jingyuan Song, Xiangdong Pu

Journal: Int J Mol Sci

PubMed ID: 37894770

Doi: 10.3390/ijms242015090

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Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells

Authors: Mihir B Doshi, Namgyu Lee, Tenzin Tseyang, Olga Ponomarova, Hira Lal Goel, Meghan Spears, Rui Li, Lihua Julie Zhu, Christopher Ashwood, Karl Simin, Cholsoon Jang, Arthur M Mercurio, Albertha J M Walhout, Jessica B Spinelli, Dohoon Kim

Journal: Nature

PubMed ID: 37880368

Doi: 10.1038/s41586-023-06676-3

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A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation

Authors: Lounis Yakhou, Anaelle Azogui, Nikhil Gupta, Julien Richard Albert, Fumihito Miura, Laure Ferry, Kosuke Yamaguchi, Sarah Battault, Pierre Therizols, Frédéric Bonhomme, Elouan Bethuel, Arpita Sarkar, Maxim V C Greenberg, Paola B Arimondo, Gael Cristofari, Olivier Kirsh, Takashi Ito, Pierre-Antoine Defossez

Journal: Nucleic Acids Res

PubMed ID: 37650637

Doi: 10.1093/nar/gkad719

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A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells

Authors: Xinlin Liu, Linli Luan, Xi Liu, Dingwen Jiang, Junwen Deng, Jiazhen Xu, Yang Yuan, Jiyao Xing, Bingguan Chen, Dongming Xing, Haiming Huang

Journal: Front Immunol

PubMed ID: 37954614

Doi: 10.3389/fimmu.2023.1292839

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Varying the expression pattern of the strigolactone receptor gene results in phenotypes distinct from both wild type and knockout mutants

Authors: Revel S M Drummond, Hui Wen Lee, Zhiwei Luo, Jack F Dakin, Bart J Janssen, Kimberley C Snowden

Journal: Front Plant Sci

PubMed ID: 37900765

Doi: 10.3389/fpls.2023.1277617

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Structure-function relationships in ShKT domain peptides: ShKT-Ts1 from the sea anemone Telmatactis stephensoni

Authors: Karoline Sanches, Lauren M Ashwood, Abisola Ave-Maria Olushola-Siedoks, Dorothy C C Wai, Arfatur Rahman, Kashmala Shakeel, Muhammad Umair Naseem, Gyorgy Panyi, Peter J Prentis, Raymond S Norton

Journal: Proteins

PubMed ID: 37794633

Doi: 10.1002/prot.26594

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Electroacupuncture at GB20 improves cognitive ability and synaptic plasticity via the CaM-CaMKII-CREB signaling pathway following cerebral ischemia-reperfusion injury in rats

Authors: Qing Han, Feng Wang

Journal: Acupunct Med

PubMed ID: 38126262

Doi: 10.1177/09645284231202805

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Profibrogenic macrophage-targeted delivery of mitochondrial protector via exosome formula for alleviating pulmonary fibrosis

Authors: Wei Zhang, Zhuo Wan, Di Qu, Wenqi Sun, Liang Zhang, Yuan Liang, Lei Pan, Hua Jiang, Zichen Ye, Mengying Wei, Lijun Yuan, Guodong Yang, Faguang Jin

Journal: Bioact Mater

PubMed ID: 37965241

Doi: 10.1016/j.bioactmat.2023.09.019

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miR-19b-3p regulated by estrogen controls lipid synthesis through targeting MSMO1 and ELOVL5 in LMH cells

Authors: Qihui Jia, Yuzhu Cao, Mengmeng Zhang, Yuxin Xing, Tian Xia, Yulong Guo, Yaxin Yue, Xin Li, Xiaojun Liu, Yanhua Zhang, Donghua Li, Zhuanjian Li, Yadong Tian, Xiangtao Kang, Hong Li

Journal: Poult Sci

PubMed ID: 37939591

Doi: 10.1016/j.psj.2023.103200

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Allosterically inhibited PFKL via prostaglandin E2 withholds glucose metabolism and ovarian cancer invasiveness

Authors: Shengmiao Chen, Yiran Wu, Yang Gao, Chenxu Wu, Yuetong Wang, Chun Hou, Miao Ren, Shuyuan Zhang, Qi Zhu, Jiali Zhang, Yufeng Yao, Mei Huang, Yingchuan B Qi, Xue-Song Liu, Tiffany Horng, Haopeng Wang, Dan Ye, Zhengjiang Zhu, Suwen Zhao, Gaofeng Fan

Journal: Cell Rep

PubMed ID: 37831605

Doi: 10.1016/j.celrep.2023.113246

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Replenishing decoy extracellular vesicles inhibits phenotype remodeling of tissue-resident cells in inflammation-driven arthritis

Authors: Mengmeng Liang, Ke Wang, Xiaoyu Wei, Xiaoshan Gong, Hao Tang, Hao Xue, Jing Wang, Pengbin Yin, Licheng Zhang, Zaisong Ma, Ce Dou, Shiwu Dong, Jianzhong Xu, Fei Luo, Qinyu Ma

Journal: Cell Rep Med

PubMed ID: 37852176

Doi: 10.1016/j.xcrm.2023.101228

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Inherited myogenic abilities in muscle precursor cells defined by the mitochondrial complex I-encoding protein

Authors: Norio Motohashi, Katsura Minegishi, Yoshitsugu Aoki

Journal: Cell Death Dis

PubMed ID: 37857600

Doi: 10.1038/s41419-023-06192-2

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Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma

Authors: Yunyun Chen, Kun Zhang, Rui Zhang, Zhuo Wang, Liang Yang, Tingting Zhao, Shihui Zhang, Yong Lin, Hongzhou Zhao, Yongpan Liu, Yuxuan Wei, Yijian Zhou, Jiaying Zhang, Xianzong Ye, Jing Zhao, Xinxin Li, Jianwen Que, Songlin Shi, Kuancan Liu

Journal: Cell Death Discov

PubMed ID: 37891174

Doi: 10.1038/s41420-023-01693-7

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Acrylamide induces neurotoxicity in zebrafish (Danio rerio) via NLRP3-mediated pyroptosis

Authors: Boya Zhang, Mengyao Zhao, Xiaoguo Ji, Quanming Xia, Lihua Jiang, Liming Zhao

Journal: Science of The Total Environment

PubMed ID: 37392875

Doi: 10.1016/j.scitotenv.2023.165208

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ROS-scavenging anti-inflammatory nucleic acid delivery system for targeted treatment of atherosclerosis

Authors: Zunjing Liua , Zihao Liub , Yi Shanc , Chen Xub , Bingran Yub, FuJian Xub

Journal: Nano Today

Doi: 10.1016/j.nantod.2023.102005

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